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Aliases for OLFM4 Gene

Aliases for OLFM4 Gene

  • Olfactomedin 4 2 3 5
  • G-CSF-Stimulated Clone 1 Protein 3 4
  • Antiapoptotic Protein GW112 3 4
  • GW112 3 4
  • HGC-1 3 4
  • HOLfD 3 4
  • OLM4 3 4
  • Olfactomedin-4 3
  • BA209J19.1 3
  • UNQ362 3
  • OlfD 3
  • GC1 3

External Ids for OLFM4 Gene

Previous GeneCards Identifiers for OLFM4 Gene

  • GC13P051401
  • GC13P052500
  • GC13P053602
  • GC13P034317

Summaries for OLFM4 Gene

Entrez Gene Summary for OLFM4 Gene

  • This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]

GeneCards Summary for OLFM4 Gene

OLFM4 (Olfactomedin 4) is a Protein Coding gene. Diseases associated with OLFM4 include Pancreatic Cancer. Among its related pathways are Innate Immune System and Adhesion. GO annotations related to this gene include protein homodimerization activity and cadherin binding. An important paralog of this gene is OLFML2B.

UniProtKB/Swiss-Prot for OLFM4 Gene

  • May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.

Additional gene information for OLFM4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFM4 Gene

Genomics for OLFM4 Gene

Regulatory Elements for OLFM4 Gene

Enhancers for OLFM4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H053027 0.2 dbSUPER 34.2 +0.3 283 2 OLFM4 GC13P053042
GH13H053015 0.6 ENCODE dbSUPER 10.6 -13.5 -13501 0 POLR2A OLFM4 GC13M052802
GH13H053020 0.5 dbSUPER 12.3 -4.6 -4569 7 PKNOX1 ZNF316 MAFG EMSY MAFK OLFM4 GC13M052802
GH13H052993 0.4 dbSUPER 14.9 -33.8 -33789 3 POLR2A OLFM4 GC13M052802
GH13H053030 0.4 dbSUPER 14.1 +3.4 3448 3 SCRT2 OLFM4 GC13P053042
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OLFM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OLFM4 Gene

Chromosome:
13
Start:
53,028,741 bp from pter
End:
53,052,061 bp from pter
Size:
23,321 bases
Orientation:
Plus strand

Genomic View for OLFM4 Gene

Genes around OLFM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFM4 Gene

Proteins for OLFM4 Gene

  • Protein details for OLFM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX06-OLFM4_HUMAN
    Recommended name:
    Olfactomedin-4
    Protein Accession:
    Q6UX06
    Secondary Accessions:
    • O95362
    • Q5VWG0
    • Q86T22

    Protein attributes for OLFM4 Gene

    Size:
    510 amino acids
    Molecular mass:
    57280 Da
    Quaternary structure:
    • Homomultimer; disulfide-linked. Interacts with NDUFA13. Interacts with cell surface lectins (locutions ricinus communis agglutinin I, concanavalin-A and wheat germ agglutinin) and cadherin.
    SequenceCaution:
    • Sequence=AAC72970.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC72970.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for OLFM4 Gene

Post-translational modifications for OLFM4 Gene

  • N-glycosylated.
  • Glycosylation at posLast=7272, posLast=136136, Asn193, posLast=253253, posLast=352352, and Asn411
  • Modification sites at PhosphoSitePlus

Other Protein References for OLFM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for OLFM4 (Olfactomedin-4/OLFM4)

No data available for DME Specific Peptides for OLFM4 Gene

Domains & Families for OLFM4 Gene

Gene Families for OLFM4 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for OLFM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UX06

UniProtKB/Swiss-Prot:

OLFM4_HUMAN :
  • The olfactomedin-like domain is involved in the interaction with cadherin.
Domain:
  • The olfactomedin-like domain is involved in the interaction with cadherin.
genes like me logo Genes that share domains with OLFM4: view

Function for OLFM4 Gene

Molecular function for OLFM4 Gene

UniProtKB/Swiss-Prot Function:
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
UniProtKB/Swiss-Prot Induction:
By retinoic acid. This induction requires functional NFKB pathway.

Phenotypes From GWAS Catalog for OLFM4 Gene

Gene Ontology (GO) - Molecular Function for OLFM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IMP 16566923
GO:0045296 cadherin binding IMP 16566923
genes like me logo Genes that share ontologies with OLFM4: view
genes like me logo Genes that share phenotypes with OLFM4: view

Animal Models for OLFM4 Gene

MGI Knock Outs for OLFM4:

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFM4

CRISPR Products

miRNA for OLFM4 Gene

miRTarBase miRNAs that target OLFM4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OLFM4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OLFM4 Gene

Localization for OLFM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFM4 Gene

Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). {ECO:0000269 PubMed:15059901, ECO:0000269 PubMed:16566923, ECO:0000269 PubMed:20724538}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFM4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OLFM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IMP 16566923
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane IDA 16566923
GO:0030141 NOT secretory granule IDA 23922742
genes like me logo Genes that share ontologies with OLFM4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OLFM4 Gene

Pathways & Interactions for OLFM4 Gene

genes like me logo Genes that share pathways with OLFM4: view

Pathways by source for OLFM4 Gene

1 Cell Signaling Technology pathway for OLFM4 Gene
3 Reactome pathways for OLFM4 Gene

Gene Ontology (GO) - Biological Process for OLFM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0010939 NOT regulation of necrotic cell death IMP 23922742
GO:0042981 NOT regulation of apoptotic process IMP 23922742
GO:0043312 neutrophil degranulation TAS --
GO:0050764 NOT regulation of phagocytosis IMP 23922742
genes like me logo Genes that share ontologies with OLFM4: view

No data available for SIGNOR curated interactions for OLFM4 Gene

Drugs & Compounds for OLFM4 Gene

No Compound Related Data Available

Transcripts for OLFM4 Gene

mRNA/cDNA for OLFM4 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(199) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OLFM4 Gene

Olfactomedin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OLFM4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OLFM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - - - - -
SP3: -
SP4:

Relevant External Links for OLFM4 Gene

GeneLoc Exon Structure for
OLFM4
ECgene alternative splicing isoforms for
OLFM4

Expression for OLFM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLFM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLFM4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x17.7), Pancreas (x11.4), Vagina (x7.7), and Colon - Transverse (x7.1).

Protein differential expression in normal tissues from HIPED for OLFM4 Gene

This gene is overexpressed in Islet of Langerhans (29.4), Neutrophil (18.8), Pancreatic juice (8.8), and Urine (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OLFM4 Gene



Protein tissue co-expression partners for OLFM4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OLFM4 Gene:

OLFM4

SOURCE GeneReport for Unigene cluster for OLFM4 Gene:

Hs.508113

mRNA Expression by UniProt/SwissProt for OLFM4 Gene:

Q6UX06-OLFM4_HUMAN
Tissue specificity: Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.

Evidence on tissue expression from TISSUES for OLFM4 Gene

  • Intestine(4.9)
  • Nervous system(4.1)
  • Kidney(2.5)
  • Bone marrow(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with OLFM4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFM4 Gene

Orthologs for OLFM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFM4 33 34
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia OLFM4 33 34
  • 85.61 (n)
cow
(Bos Taurus)
Mammalia OLFM4 33 34
  • 81.77 (n)
rat
(Rattus norvegicus)
Mammalia Olfm4 33
  • 79.68 (n)
mouse
(Mus musculus)
Mammalia Olfm4 33 16 34
  • 79.01 (n)
oppossum
(Monodelphis domestica)
Mammalia OLFM4 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLFM4 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLFM4 33 34
  • 65.98 (n)
lizard
(Anolis carolinensis)
Reptilia OLFM4 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfm4 33
  • 58.15 (n)
Str.6175 33
African clawed frog
(Xenopus laevis)
Amphibia Tiarin 33
zebrafish
(Danio rerio)
Actinopterygii LOC569427 33
  • 50.32 (n)
OLFM4 (7 of 8) 34
  • 37 (a)
OneToMany
OLFM4 (2 of 8) 34
  • 35 (a)
OneToMany
OLFM4 (8 of 8) 34
  • 35 (a)
OneToMany
OLFM4 (1 of 8) 34
  • 34 (a)
OneToMany
OLFM4 (4 of 8) 34
  • 30 (a)
OneToMany
OLFM4 (5 of 8) 34
  • 28 (a)
OneToMany
OLFM4 (6 of 8) 34
  • 27 (a)
OneToMany
OLFM4 (3 of 8) 34
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6867 34
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cof-2 34
  • 15 (a)
ManyToMany
unc-122 34
  • 13 (a)
ManyToMany
Species where no ortholog for OLFM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLFM4 Gene

ENSEMBL:
Gene Tree for OLFM4 (if available)
TreeFam:
Gene Tree for OLFM4 (if available)

Paralogs for OLFM4 Gene

Paralogs for OLFM4 Gene

Pseudogenes.org Pseudogenes for OLFM4 Gene

genes like me logo Genes that share paralogs with OLFM4: view

Variants for OLFM4 Gene

Sequence variations from dbSNP and Humsavar for OLFM4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000076130 -- 53,032,977(+) TGTCT(C/T)CTTAG intron-variant
rs1000149568 -- 53,033,380(+) GGATG(C/T)TAATT intron-variant
rs1000418724 -- 53,027,505(+) GCCAC(C/T)GACTC upstream-variant-2KB
rs1000799525 -- 53,034,993(+) TTGCC(C/T)TTATT intron-variant
rs1000807068 -- 53,030,171(+) ACAGA(C/T)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFM4 Gene

Variant ID Type Subtype PubMed ID
esv3632112 CNV loss 21293372
nsv832613 CNV gain 17160897

Variation tolerance for OLFM4 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLFM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFM4 Gene

Disorders for OLFM4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OLFM4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic cancer
  • pancreatic carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search OLFM4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OLFM4

Genetic Association Database (GAD)
OLFM4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLFM4
genes like me logo Genes that share disorders with OLFM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OLFM4 Gene

Publications for OLFM4 Gene

  1. A genome-wide association meta-analysis identifies new childhood obesity loci. (PMID: 22484627) Bradfield JP … Early Growth Genetics Consortium (Nature genetics 2012) 3 45 60
  2. Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis. (PMID: 20724538) Liu W … Rodgers GP (Blood 2010) 3 4 60
  3. Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients. (PMID: 19670418) Oue N … Yasui W (International journal of cancer 2009) 3 22 60
  4. Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells. (PMID: 17270022) Kobayashi D … Watanabe N (Cancer science 2007) 4 22 60
  5. The glycoprotein hGC-1 binds to cadherin and lectins. (PMID: 16566923) Liu W … Rodgers GP (Experimental cell research 2006) 3 4 60

Products for OLFM4 Gene

Sources for OLFM4 Gene

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