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Aliases & Descriptions for OLFM4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| GC1 1, 2 | | GW112 1, 2, 3 | | KIAA4294 2 | | OLM4 2, 3 | | OTTHUMP00000018468 2 | | OTTHUMP00000018469 2 | | OlfD 1, 2 | | UNQ362 2 | | bA209J19.1 2 | | hGC-1 2, 3 | | hOLfD 2, 3 |
| | | Descriptions |
|---|
| Antiapoptotic protein GW112 3 | | G-CSF-stimulated clone 1 protein 3 | | olfactomedin 4 2 |
|
| | Search outside databases for aliases for OLFM4 genePrevious GC identifer: GC13P051401 |
Summaries for OLFM4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for OLFM4: This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. The protein encoded is a member of the olfactomedin-related protein family. The exact function of this gene has not yet been determined. [provided by RefSeq] UniProtKB/Swiss-Prot: OLFM4_HUMAN, Q6UX06Function: An antiapoptotic factor that promotes tumor growth. Promotes proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. Facilitates cell adhesion |
Genomic Location for OLFM4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OLFM4 gene 
Entrez Gene cytogenetic band: 13q21.1 Ensembl cytogenetic band: 13q21.1 HGNC cytogenetic band: 13q14OLFM4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P052500:
(about GC identifiers)
Start:
|
52,500,960 bp from pter |
End:
|
52,524,193 bp from pter |
Size:
|
23,234 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000013.9 NT_024524.13
| Proteins for OLFM4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: OLFM4_HUMAN, Q6UX06 (See
protein sequence)Recommended Name: Olfactomedin-4 precursor Size: 510 amino acids; 57280 Da
Subunit: Homomultimer; disulfide-linked. Interacts with NDUFA13. Interacts with cell surface lectins (locutions ricinus communis agglutinin I, concanavalin A and wheat germ agglutinin) and cadherin
Subcellular location: Secreted, extracellular space. Note=According to PubMed:15059901 found in mitochondrion and nucleus
Sequence caution: Sequence=AAC72970.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAC72970.1; Type=Frameshift; Positions=Several;
Secondary accessions: O95362 Q5VWG0 Q86T22Post-translational modifications:
N-glycosylated1
REFSEQ proteins: NP_006409.3
ENSEMBL proteins: ENSP00000219022
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005615 | extracellular space |
IEA | -- | About this table
Antibodies for OLFM4: Assays for OLFM4: | Protein
Domains/ Families for OLFM4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6UX06
ProtoNet protein and cluster: Q6UX06 1 Blocks protein family: IPB003112 Olfactomedin-like
UniProtKB/Swiss-Prot: OLFM4_HUMAN, Q6UX06Domain: The olfactomedin-like domain is involved in the interaction with cadherinSimilarity: Contains 1 olfactomedin-like domain | Gene Function for OLFM4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006418
Applied Biosystems Silencer® siRNAs for OLFM4
Sigma-Aldrich siRNA for OLFM4  Sigma-Aldrich shRNA for OLFM4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006418                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006418                                  untagged cDNA clone in CMV expression vector: NM_006418 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006418
UniProtKB/Swiss-Prot: OLFM4_HUMAN, Q6UX06Function: An antiapoptotic factor that promotes tumor growth. Promotes proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. Facilitates cell adhesion1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for OLFM4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for OLFM4 (ENSP000002190223) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- | About this table
|
Drugs & Compounds for OLFM4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for OLFM4
|
Transcripts for OLFM4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006418
Sigma-Aldrich siRNA for OLFM4  Sigma-Aldrich shRNA for OLFM4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006418 REFSEQ mRNAs for OLFM4 gene: NM_006418.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006418               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006418                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006418                                  untagged cDNA clone in CMV expression vector: NM_006418  Additional cDNA sequence: AK000683.1 AK300947.1 AY358567.1 BC047740.1 BC117329.1 8 DOTS entries: DT.446263 DT.100785237 DT.91810361 DT.100785238 DT.120771779 DT.95293320 DT.86848031 DT.97787537 24/199 AceView cDNA sequences (see all 199
):AI422584 AI699868 BF222239 NM_006418 BX483055 AI565909 AA417910 AI635039 AI812031 T35699 BX483950 AW513818 AI923293 AI799729 AI811793 T24449 T34936 BX482217 AI827323 AI420765 AI859018 AW572449 AI587610 AI625261
highest scoring ESTs for OLFM4:AA366895 AA372630 AA376957 AA377282 AA417910 AA418161 AA531507 AA553882 AA555066 AA582775 Unigene Cluster for OLFM4: Olfactomedin 4 Hs.508113 [show with all ESTs]Unigene Representative Sequence: AY358567
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for OLFM4
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | |
| SP1: | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | - |   | |   | - |   | - |   | - |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for OLFM4
1 Ensembl transcript including schematic representation: ENST00000219022
|
Expression for OLFM4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OLFM4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OLFM4
1 / 2 / 3 3 probe-sets matching OLFM4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TAATTTTTGC
SOURCE GeneReport for Unigene cluster: Hs.508113
Expression variation in blood from EXPOLDB for OLFM4 UniProtKB/Swiss-Prot: OLFM4_HUMAN, Q6UX06Tissue specificity: Expressed during myeloid lineage development. Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Highly expressed in pancreatic cancer tissues and shows an elevated expression level during the early S phase of the cell cycle. Also expressed at high levels in stomach cancer and colon cancer tissues |
Orthologs for OLFM4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OLFM4 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for OLFM4
ENSEMBL Gene Tree for OLFM4 | Paralogs for OLFM4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for OLFM4 gene
- GLDN2 OLFML32 OLFML12
|
SNPs/Variants for OLFM4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OLFM4 (up to first 250kb)
|
Disorders & Mutations for OLFM4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for OLFM4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OLFM4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for OLFM4 gene (see all 16
):- The glycoprotein hGC-1 binds to cadherin and lectins. (PubMed id 16566923)3, 4 Liu W.... Rodgers G.P. (2006)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development. (PubMed id 11867215)3, 4 Zhang J.... Rodgers G.P. (2002)
- Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells. (PubMed id 17270022)1, 4 Kobayashi D.... Watanabe N. (2007)
- Identification of new accessible tumor antigens in human colon cancer by ex vivo protein biotinylation and comparative mass spectrometry analysis. (PubMed id 18798264)3 Conrotto P....Castronovo V. (2008)
- Reduced hGC-1 protein expression is associated with malignant progression of colon carcinoma. (PubMed id 18281536)3 Liu W....Rodgers G.P. (2008)
- Expression of hGC-1 is correlated with differentiation of gastric carcinoma. (PubMed id 17650212)3 Liu W....Rodgers G.P. (2007)
- GW112, a novel antiapoptotic protein that promotes tumor growth. (PubMed id 15059901)4 Zhang X.... Li C.-Y. (2004)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)4 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
|
Search for OLFM4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OLFM4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OLFM4
(According to HUGE)
About This Section
| |
Specialized Databases showing OLFM4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for OLFM4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OLFM4:

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Incremental update: 13 Oct 2009
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