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OLFM4 Gene

protein-coding   GIFtS: 54
GCID: GC13P053602

Olfactomedin 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactomedin 41 2     hOLfD2 3
GW1122 3 5     GC12 5
Antiapoptotic Protein GW1122 3     OlfD2
OLM42 3     UNQ3622
G-CSF-Stimulated Clone 1 Protein2 3     bA209J19.12
hGC-12 3     olfactomedin-42

External Ids:    HGNC: 171901   Entrez Gene: 105622   Ensembl: ENSG000001028377   OMIM: 6140615   UniProtKB: Q6UX063   

Export aliases for OLFM4 gene to outside databases

Previous GC identifers: GC13P051401 GC13P052500 GC13P034317


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OLFM4 Gene:
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic
epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor
that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. (provided
by RefSeq, Mar 2011)

GeneCards Summary for OLFM4 Gene:
OLFM4 (olfactomedin 4) is a protein-coding gene. An important paralog of this gene is GLDN.

UniProtKB/Swiss-Prot: OLFM4_HUMAN, Q6UX06
Function: May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M
phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May
play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably
through interaction with cell surface lectins and cadherin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the OLFM4 gene promoter:
         LHX3b/Lhx3b   CUTL1   C/EBPalpha   NF-AT   RORalpha2   HSF2   LHX3a/Lhx3a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOLFM4 promoter sequence
   Search Chromatin IP Primers for OLFM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OLFM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q14

OLFM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLFM4 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P053602:  view genomic region     (about GC identifiers)

Start:
53,602,876 bp from pter      End:
53,626,196 bp from pter
Size:
23,321 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OLFM4_HUMAN, Q6UX06 (See protein sequence)
Recommended Name: Olfactomedin-4 precursor  
Size: 510 amino acids; 57280 Da
Subunit: Homomultimer; disulfide-linked. Interacts with NDUFA13. Interacts with cell surface lectins (locutions
ricinus communis agglutinin I, concanavalin-A and wheat germ agglutinin) and cadherin
Developmental stage: Elevated expression during the early S phase of the cell cycle, followed by a gradual
decrease during late S phase
Sequence caution: Sequence=AAC72970.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC72970.1; Type=Frameshift; Positions=Several;
Secondary accessions: O95362 Q5VWG0 Q86T22

Explore the universe of human proteins at neXtProt for OLFM4: NX_Q6UX06

Explore proteomics data for OLFM4 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn72, Asn136, Asn193, Asn253, Asn352, Asn411

  • See OLFM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006409.3  
    ENSEMBL proteins: 
     ENSP00000219022  

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    antibodies-online proteins for OLFM4 (10 products) 

     
    antibodies-online peptides for OLFM4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003112 Olfac-like
     IPR011041 Quinoprot_gluc/sorb_DH

    Graphical View of Domain Structure for InterPro Entry Q6UX06

    ProtoNet protein and cluster: Q6UX06

    1 Blocks protein domain: IPB003112 Olfactomedin-like

    UniProtKB/Swiss-Prot: OLFM4_HUMAN, Q6UX06
    Domain: The olfactomedin-like domain is involved in the interaction with cadherin
    Similarity: Contains 1 olfactomedin-like domain


    Find genes that share domains with OLFM4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OLFM4_HUMAN, Q6UX06
    Function: May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M
    phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May
    play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably
    through interaction with cell surface lectins and cadherin
    Induction: By retinoic acid. This induction requires functional NFKB pathway

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IMP16566923
    GO:0045296cadherin binding IMP16566923
         
    Find genes that share ontologies with OLFM4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for OLFM4:
     Increased S DNA content  Increased cell size 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Olfm4):
     digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with OLFM4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Olfm4tm1Gpro for OLFM4

       genOway: Develop your customized and physiologically relevant rodent model for OLFM4

    miRNA
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    miRTarBase miRNAs that target OLFM4:
    hsa-mir-335-5p (MIRT018486)

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    Selected qRT-PCR Assays for microRNAs that regulate OLFM4 (see all 17):
    hsa-let-7d hsa-let-7c hsa-miR-486-5p hsa-let-7g hsa-let-7a hsa-miR-558 hsa-miR-186 hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidOLFM4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OLFM4_HUMAN, Q6UX06: Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly
    defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and
    PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion5
    cytosol1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IMP16566923
    GO:0005739mitochondrion IEA--
    GO:0005886plasma membrane IDA16566923
    GO:0030141NOT secretory granule IDA--
    GO:0042581specific granule IDA--

    Find genes that share ontologies with OLFM4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OLFM4
    Interactions:

        Search GeneGlobe Interaction Network for OLFM4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for OLFM4 (Q6UX063 ENSP000002190224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C3P010243, ENSP000002459074I2D: score=1 STRING: ENSP00000245907
    NDUFA13Q9P0J03I2D: score=1 
    NOD1ENSP000002228234STRING: ENSP00000222823
    NOD2ENSP000003005894STRING: ENSP00000300589
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0010939NOT regulation of necrotic cell death IMP--
    GO:0042981NOT regulation of apoptotic process IMP--
    GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling IEA--
    GO:0050764NOT regulation of phagocytosis IMP--

    Find genes that share ontologies with OLFM4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OLFM4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OLFM4 gene: 
    NM_006418.4  

    Unigene Cluster for OLFM4:

    Olfactomedin 4
    Hs.508113  [show with all ESTs]
    Unigene Representative Sequence: NM_006418
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000219022(uc001vhk.2 uc001vhl.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate OLFM4 (see all 17):
    hsa-let-7d hsa-let-7c hsa-miR-486-5p hsa-let-7g hsa-let-7a hsa-miR-558 hsa-miR-186 hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidOLFM4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK000683.1 AK300947.1 AY358567.1 BC047740.1 BC117329.1 

    8 DOTS entries:

    DT.446263  DT.100785237  DT.91810361  DT.100785238  DT.120771779  DT.95293320  DT.86848031  DT.97787537 

    Selected AceView cDNA sequences (see all 199):

    BX482217 BF447309 AI827323 AI422584 AI457140 AI859018 AW513818 AI923293 
    AI799729 AI559141 AW572449 AI867651 AI625261 AW605231 AW572458 T35699 
    AI812031 BM850418 AI560739 AI564392 AI587610 AI601121 NM_006418 AW192191 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OLFM4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:              -           -                                             
    SP2:              -           -           -     -     -     -               
    SP3:                          -                                             
    SP4:                                                                        


    ECgene alternative splicing isoforms for OLFM4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OLFM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTTTTGC
    OLFM4 Expression
    About this image


    OLFM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Colon (Gastrointestinal Tract)
     
     Prostate (Endocrine System)
    OLFM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OLFM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508113

    UniProtKB/Swiss-Prot: OLFM4_HUMAN, Q6UX06
    Tissue specificity: Expressed during myeloid lineage development. Much higher expression in bone marrow
    neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small
    intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic
    cancer tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for OLFM4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfm41 , 5 olfactomedin 41, 5 79.01(n)1
    75.85(a)1
      14 (42.78 cM)5
    3809241  NM_001030294.11  NP_001025465.11 
     800003025 
    chicken
    (Gallus gallus)
    Aves OLFM41 olfactomedin 4 65.98(n)
    59.54(a)
      418826  NM_001040463.1  NP_001035553.1 
    lizard
    (Anolis carolinensis)
    Reptilia OLFM46
    olfactomedin 4
    61(a)
    1 ↔ 1
    3(71184062-71223609)
    African clawed frog
    (Xenopus laevis)
    Amphibia Tiarin2 Tiarin protein 74.23(n)    AB075925.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5694271 olfactomedin-4-like 50.32(n)
    41.02(a)
      569427  XM_692811.5  XP_697903.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68676
    --
    9(a)
    1 → many
    X(17917903-17922294)
    worm
    (Caenorhabditis elegans)
    Secernentea cof-26
    unc-1226
    Protein UNC-122 (unc-122) mRNA, complete cds
    15(a)
    13(a)
    many ↔ many
    many ↔ many
    I(6250571-6252821) WBGene00000583
    I(14872162-14875378) WBGene00006845


    ENSEMBL Gene Tree for OLFM4 (if available)
    TreeFam Gene Tree for OLFM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OLFM4 gene
    GLDN2  OLFM32  OLFML32  OLFML2A2  OLFM12  OLFM22  OLFML2B2  MYOC2  
    OLFML12  

    Find genes that share paralogs with OLFM4           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for OLFM4
    PGOHUM00000250356 PGOHUM00000250151


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OLFM4 (see all 568)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs79966331,2
    C,F--53601164(+) CTTGGA/GCTGGG 1 -- us2k12Minor allele frequency- G:0.05WA 120
    rs1513098011,2
    --53601170(+) CTGGGG/TATCTA 1 -- us2k10--------
    rs800906131,2
    --53601180(+) AAGTGA/GTTAGA 1 -- us2k10--------
    rs1812636681,2
    --53601280(+) ACTCTA/CTATCC 1 -- us2k10--------
    rs1853273241,2
    --53601393(+) GCTTAC/TTCTGA 1 -- us2k10--------
    rs1913546531,2
    --53601545(+) CAAAAA/GTCATA 1 -- us2k10--------
    rs1179005021,2
    C,F--53601585(+) TTCAAA/GCAATT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs21859591,2
    C,F,A,H--53601630(+) CATGCC/TCAAGG 1 -- us2k113Minor allele frequency- T:0.28NA WA CSA EA 378
    rs65617031,2
    C,F,A--53601742(+) actacA/Tgccgc 1 -- us2k13Minor allele frequency- T:0.23WA CSA 122
    rs1139918911,2
    C--53601899(+) CTCAAG/TCCATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OLFM4 (53602876 - 53626196 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OLFM4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832613CNV Gain17160897

    Human Gene Mutation Database (HGMD): OLFM4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OLFM4
    DNA2.0 Custom Variant and Variant Library Synthesis for OLFM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614061    OMIM disorders: --


    Find genes that share disorders with OLFM4           About GenesLikeMe

    Genetic Association Database (GAD): OLFM4

    Export disorders for OLFM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OLFM4 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with OLFM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association meta-analysis identifies new childhood obesity loci. (PubMed id 22484627)1, 4 Bradfield J.P....Grant S.F. (Nat. Genet. 2012)
    2. Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'- deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis. (PubMed id 20724538)1, 2 Liu W.... Rodgers G.P. (Blood 2010)
    3. The glycoprotein hGC-1 binds to cadherin and lectins. (PubMed id 16566923)1, 2 Liu W.... Rodgers G.P. (Exp. Cell Res. 2006)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development. (PubMed id 11867215)1, 2 Zhang J.... Rodgers G.P. (Gene 2002)
    6. Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients. (PubMed id 19670418)1, 9 Oue N....Yasui W. (Int. J. Cancer 2009)
    7. Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells. (PubMed id 17270022)2, 9 Kobayashi D.... Watanabe N. (Cancer Sci. 2007)
    8. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
    9. Expression of olfactomedin 4 and claudin-18 in serrated neoplasia of the colorectum: a characteristic pattern is associated with sessile serrated lesion. (PubMed id 23570326)1 Sentani K....Yasui W. (Histopathology 2013)
    10. Olfactomedin 4 defines a subset of human neutrophils. (PubMed id 22187488)1 Clemmensen S.N....Borregaard N. (J. Leukoc. Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10562 HGNC: 17190 AceView: OLFM4 Ensembl:ENSG00000102837 euGenes: HUgn10562
    ECgene: OLFM4 H-InvDB: OLFM4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OLFM4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OLFM4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OLFM4 gene:
    Search GeneIP for patents involving OLFM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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