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Aliases for OLFM4 Gene

Aliases for OLFM4 Gene

  • Olfactomedin 4 2 3
  • GW112 3 4 6
  • G-CSF-Stimulated Clone 1 Protein 3 4
  • Antiapoptotic Protein GW112 3 4
  • HGC-1 3 4
  • HOLfD 3 4
  • OLM4 3 4
  • GC1 3 6
  • Olfactomedin-4 3
  • BA209J19.1 3
  • UNQ362 3
  • OlfD 3

External Ids for OLFM4 Gene

Previous GeneCards Identifiers for OLFM4 Gene

  • GC13P051401
  • GC13P052500
  • GC13P053602
  • GC13P034317

Summaries for OLFM4 Gene

Entrez Gene Summary for OLFM4 Gene

  • This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]

GeneCards Summary for OLFM4 Gene

OLFM4 (Olfactomedin 4) is a Protein Coding gene. An important paralog of this gene is GLDN.

UniProtKB/Swiss-Prot for OLFM4 Gene

  • May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFM4 Gene

Genomics for OLFM4 Gene

Regulatory Elements for OLFM4 Gene

Genomic Location for OLFM4 Gene

Start:
53,028,741 bp from pter
End:
53,052,061 bp from pter
Size:
23,321 bases
Orientation:
Plus strand

Genomic View for OLFM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLFM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFM4 Gene

Proteins for OLFM4 Gene

  • Protein details for OLFM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX06-OLFM4_HUMAN
    Recommended name:
    Olfactomedin-4
    Protein Accession:
    Q6UX06
    Secondary Accessions:
    • O95362
    • Q5VWG0
    • Q86T22

    Protein attributes for OLFM4 Gene

    Size:
    510 amino acids
    Molecular mass:
    57280 Da
    Quaternary structure:
    • Homomultimer; disulfide-linked. Interacts with NDUFA13. Interacts with cell surface lectins (locutions ricinus communis agglutinin I, concanavalin-A and wheat germ agglutinin) and cadherin.
    SequenceCaution:
    • Sequence=AAC72970.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC72970.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for OLFM4 Gene

Proteomics data for OLFM4 Gene at MOPED

Post-translational modifications for OLFM4 Gene

Other Protein References for OLFM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for OLFM4 (OLFM4)

No data available for DME Specific Peptides for OLFM4 Gene

Domains for OLFM4 Gene

Protein Domains for OLFM4 Gene

Suggested Antigen Peptide Sequences for OLFM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UX06

UniProtKB/Swiss-Prot:

OLFM4_HUMAN :
  • Q6UX06
Domain:
  • The olfactomedin-like domain is involved in the interaction with cadherin.
  • Contains 1 olfactomedin-like domain.
genes like me logo Genes that share domains with OLFM4: view

No data available for Gene Families for OLFM4 Gene

Function for OLFM4 Gene

Molecular function for OLFM4 Gene

UniProtKB/Swiss-Prot Function: May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
UniProtKB/Swiss-Prot Induction: By retinoic acid. This induction requires functional NFKB pathway.

Gene Ontology (GO) - Molecular Function for OLFM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IMP 16566923
GO:0045296 cadherin binding IMP 16566923
genes like me logo Genes that share ontologies with OLFM4: view
genes like me logo Genes that share phenotypes with OLFM4: view

Animal Models for OLFM4 Gene

MGI Knock Outs for OLFM4:

Animal Model Products

CRISPR Products

miRNA for OLFM4 Gene

miRTarBase miRNAs that target OLFM4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for OLFM4 Gene

Localization for OLFM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFM4 Gene

Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). {ECO:0000269 PubMed:15059901, ECO:0000269 PubMed:16566923, ECO:0000269 PubMed:20724538}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLFM4 Gene COMPARTMENTS Subcellular localization image for OLFM4 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for OLFM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IMP 16566923
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane IDA 16566923
GO:0030141 NOT secretory granule IDA 23922742
GO:0042581 specific granule IDA 23922742
genes like me logo Genes that share ontologies with OLFM4: view

Pathways for OLFM4 Gene

SuperPathways for OLFM4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLFM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0008152 metabolic process IEA --
GO:0010939 NOT regulation of necrotic cell death IMP 23922742
GO:0042981 NOT regulation of apoptotic process IMP 23922742
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with OLFM4: view

No data available for Pathways by source for OLFM4 Gene

Transcripts for OLFM4 Gene

mRNA/cDNA for OLFM4 Gene

(199) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OLFM4 Gene

Olfactomedin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLFM4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - - - - -
SP3: -
SP4:

Relevant External Links for OLFM4 Gene

GeneLoc Exon Structure for
OLFM4
ECgene alternative splicing isoforms for
OLFM4

Expression for OLFM4 Gene

mRNA expression in normal human tissues for OLFM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLFM4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (17.7), Pancreas (11.4), Vagina (7.7), and Colon - Transverse (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OLFM4 Gene

SOURCE GeneReport for Unigene cluster for OLFM4 Gene Hs.508113

mRNA Expression by UniProt/SwissProt for OLFM4 Gene

Q6UX06-OLFM4_HUMAN
Tissue specificity: Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.
genes like me logo Genes that share expressions with OLFM4: view

In Situ Assay Products

Orthologs for OLFM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFM4 35
  • 99.48 (n)
  • 99.8 (a)
OLFM4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OLFM4 35
  • 81.77 (n)
  • 77.23 (a)
OLFM4 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLFM4 35
  • 85.61 (n)
  • 83 (a)
OLFM4 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfm4 35
  • 79.01 (n)
  • 75.85 (a)
Olfm4 16
Olfm4 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLFM4 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLFM4 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olfm4 35
  • 79.68 (n)
  • 76.98 (a)
chicken
(Gallus gallus)
Aves OLFM4 35
  • 65.98 (n)
  • 59.54 (a)
OLFM4 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFM4 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Tiarin 35
tropical clawed frog
(Silurana tropicalis)
Amphibia olfm4 35
  • 58.15 (n)
  • 54.39 (a)
Str.6175 35
zebrafish
(Danio rerio)
Actinopterygii LOC569427 35
  • 50.32 (n)
  • 41.02 (a)
OLFM4 (1 of 8) 36
  • 34 (a)
OneToMany
OLFM4 (2 of 8) 36
  • 35 (a)
OneToMany
OLFM4 (3 of 8) 36
  • 26 (a)
OneToMany
OLFM4 (4 of 8) 36
  • 30 (a)
OneToMany
OLFM4 (5 of 8) 36
  • 28 (a)
OneToMany
OLFM4 (6 of 8) 36
  • 27 (a)
OneToMany
OLFM4 (7 of 8) 36
  • 37 (a)
OneToMany
OLFM4 (8 of 8) 36
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6867 36
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cof-2 36
  • 15 (a)
ManyToMany
unc-122 36
  • 13 (a)
ManyToMany
Species with no ortholog for OLFM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLFM4 Gene

ENSEMBL:
Gene Tree for OLFM4 (if available)
TreeFam:
Gene Tree for OLFM4 (if available)

Paralogs for OLFM4 Gene

Paralogs for OLFM4 Gene

Pseudogenes.org Pseudogenes for OLFM4 Gene

genes like me logo Genes that share paralogs with OLFM4: view

Variants for OLFM4 Gene

Sequence variations from dbSNP and Humsavar for OLFM4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs12552 -- 53,051,646(-) AAAGT(C/T)CATAA utr-variant-3-prime
rs1343611 -- 53,048,737(-) TTGGC(C/T)TGAAA intron-variant
rs1419221 -- 53,051,775(-) AAATT(A/G)CATGC utr-variant-3-prime
rs1419223 -- 53,051,450(-) GGTGG(A/C)CAATG utr-variant-3-prime
rs1891945 -- 53,033,205(+) TATGC(A/G)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFM4 Gene

Variant ID Type Subtype PubMed ID
nsv832613 CNV Gain 17160897

Relevant External Links for OLFM4 Gene

HapMap Linkage Disequilibrium report
OLFM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFM4 Gene

Disorders for OLFM4 Gene

Relevant External Links for OLFM4

Genetic Association Database (GAD)
OLFM4
genes like me logo Genes that share disorders with OLFM4: view

No data available for UniProtKB/Swiss-Prot for OLFM4 Gene

Publications for OLFM4 Gene

  1. Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells. (PMID: 17270022) Kobayashi D. … Watanabe N. (Cancer Sci. 2007) 4 23
  2. Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients. (PMID: 19670418) Oue N. … Yasui W. (Int. J. Cancer 2009) 3 23
  3. Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development. (PMID: 11867215) Zhang J. … Rodgers G.P. (Gene 2002) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'- deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis. (PMID: 20724538) Liu W. … Rodgers G.P. (Blood 2010) 3 4

Products for OLFM4 Gene

Sources for OLFM4 Gene

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