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Aliases for OLFM3 Gene

Aliases for OLFM3 Gene

  • Olfactomedin 3 2 3
  • OPTIMEDIN 3 4
  • NOE3 3 4
  • Olfactomedin Related ER Localized Protein 3 3
  • Olfactomedin-3 4
  • Optimedin 2
  • Noelin-3 3
  • NOELIN3 3

External Ids for OLFM3 Gene

Previous GeneCards Identifiers for OLFM3 Gene

  • GC01M103097
  • GC01M101449
  • GC01M101559
  • GC01M101731
  • GC01M101980
  • GC01M102040
  • GC01M102268
  • GC01M100394

Summaries for OLFM3 Gene

GeneCards Summary for OLFM3 Gene

OLFM3 (Olfactomedin 3) is a Protein Coding gene. An important paralog of this gene is GLDN.

Gene Wiki entry for OLFM3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFM3 Gene

Genomics for OLFM3 Gene

Regulatory Elements for OLFM3 Gene

Genomic Location for OLFM3 Gene

Start:
101,802,567 bp from pter
End:
101,997,234 bp from pter
Size:
194,668 bases
Orientation:
Minus strand

Genomic View for OLFM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLFM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFM3 Gene

Proteins for OLFM3 Gene

  • Protein details for OLFM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PB7-NOE3_HUMAN
    Recommended name:
    Noelin-3
    Protein Accession:
    Q96PB7
    Secondary Accessions:
    • Q5T3V6
    • Q6IMI7
    • Q6IMI8
    • Q6IMI9
    • Q6IMJ1
    • Q8TBG1
    • Q96PB2
    • Q96PB3
    • Q96PB4
    • Q96PB5
    • Q96PB6

    Protein attributes for OLFM3 Gene

    Size:
    478 amino acids
    Molecular mass:
    54930 Da
    Quaternary structure:
    • Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM3. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Homodimer. Interacts with MYOC (By similarity).

    Alternative splice isoforms for OLFM3 Gene

neXtProt entry for OLFM3 Gene

Proteomics data for OLFM3 Gene at MOPED

Post-translational modifications for OLFM3 Gene

  • Glycosylation at Asn33, Asn95, Asn179, Asn299, and Asn465
  • Modification sites at PhosphoSitePlus

Other Protein References for OLFM3 Gene

No data available for DME Specific Peptides for OLFM3 Gene

Domains for OLFM3 Gene

Protein Domains for OLFM3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PB7

UniProtKB/Swiss-Prot:

NOE3_HUMAN :
  • Q96PB7
Domain:
  • Contains 1 olfactomedin-like domain.
genes like me logo Genes that share domains with OLFM3: view

No data available for Gene Families for OLFM3 Gene

Function for OLFM3 Gene

Gene Ontology (GO) - Molecular Function for OLFM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12019210
genes like me logo Genes that share ontologies with OLFM3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLFM3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OLFM3 Gene

Localization for OLFM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFM3 Gene

Secreted. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLFM3 Gene COMPARTMENTS Subcellular localization image for OLFM3 gene
Compartment Confidence
extracellular 3
golgi apparatus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for OLFM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005794 Golgi apparatus IEA --
GO:0030054 cell junction IEA --
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with OLFM3: view

Pathways for OLFM3 Gene

SuperPathways for OLFM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLFM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042462 eye photoreceptor cell development IEA --
genes like me logo Genes that share ontologies with OLFM3: view

No data available for Pathways by source for OLFM3 Gene

Transcripts for OLFM3 Gene

Unigene Clusters for OLFM3 Gene

Olfactomedin 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLFM3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFM3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: -
SP3: - - - -
SP4: -
SP5: - - -

Relevant External Links for OLFM3 Gene

GeneLoc Exon Structure for
OLFM3
ECgene alternative splicing isoforms for
OLFM3

Expression for OLFM3 Gene

mRNA expression in normal human tissues for OLFM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLFM3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (10.1), Brain - Anterior cingulate cortex (BA24) (8.0), Brain - Cortex (6.1), and Brain - Cerebellar Hemisphere (5.1).

Protein differential expression in normal tissues for OLFM3 Gene

This gene is overexpressed in Frontal cortex (65.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OLFM3 Gene

SOURCE GeneReport for Unigene cluster for OLFM3 Gene Hs.484475

mRNA Expression by UniProt/SwissProt for OLFM3 Gene

Q96PB7-NOE3_HUMAN
Tissue specificity: In the eye, expressed in trabecular meshwork and neural retina; in non-ocular tissues, expressed in brain and lung.
genes like me logo Genes that share expressions with OLFM3: view

Expression partners for OLFM3 Gene

In Situ Assay Products

Orthologs for OLFM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFM3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OLFM3 35
  • 93.64 (n)
  • 99.08 (a)
OLFM3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLFM3 35
  • 94.42 (n)
  • 99.79 (a)
OLFM3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfm3 35
  • 91.21 (n)
  • 98.95 (a)
Olfm3 16
Olfm3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OLFM3 35
  • 96.94 (n)
  • 96.94 (a)
OLFM3 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olfm3 35
  • 90.93 (n)
  • 98.95 (a)
oppossum
(Monodelphis domestica)
Mammalia OLFM3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLFM3 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLFM3 35
  • 86.26 (n)
  • 97.7 (a)
OLFM3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFM3 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfm3 35
  • 74.65 (n)
  • 85.71 (a)
zebrafish
(Danio rerio)
Actinopterygii olfm3a 35
  • 75.13 (n)
  • 86.37 (a)
olfm3a 36
  • 84 (a)
OneToMany
olfm3b 36
  • 84 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for OLFM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFM3 Gene

ENSEMBL:
Gene Tree for OLFM3 (if available)
TreeFam:
Gene Tree for OLFM3 (if available)

Paralogs for OLFM3 Gene

Paralogs for OLFM3 Gene

Selected SIMAP similar genes for OLFM3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OLFM3: view

Variants for OLFM3 Gene

Sequence variations from dbSNP and Humsavar for OLFM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs534342 -- 101,821,028(-) AGGGC(A/C)TATAA intron-variant
rs537585 -- 101,855,882(-) TTGTT(C/T)TTTCA intron-variant
rs568856 -- 101,854,738(-) GAGCT(C/T)TTAAG intron-variant
rs578308 -- 101,850,474(+) CATTA(A/G)AATTT intron-variant
rs579223 -- 101,850,600(+) GGTTT(C/T)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFM3 Gene

Variant ID Type Subtype PubMed ID
nsv522921 CNV Loss 19592680
dgv276n71 CNV Gain 21882294
nsv2143 CNV Insertion 18451855
esv2670818 CNV Deletion 23128226
nsv522156 CNV Gain 19592680
nsv441701 CNV CNV 18776908
esv2673123 CNV Deletion 23128226
nsv520768 CNV Loss 19592680
dgv74e1 CNV Complex 17122850
essv16578 CNV CNV 17122850
nsv508026 CNV Loss 20534489
esv2422183 CNV Deletion 17116639

Relevant External Links for OLFM3 Gene

HapMap Linkage Disequilibrium report
OLFM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFM3 Gene

Disorders for OLFM3 Gene

Relevant External Links for OLFM3

Genetic Association Database (GAD)
OLFM3
Human Genome Epidemiology (HuGE) Navigator
OLFM3

No disorders were found for OLFM3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OLFM3 Gene

Publications for OLFM3 Gene

  1. Optimedin: a novel olfactomedin-related protein that interacts with myocilin. (PMID: 12019210) Torrado M. … Tomarev S.I. (Hum. Mol. Genet. 2002) 2 3 4 23
  2. The Optimedin gene is a downstream target of Pax6. (PMID: 16115881) Grinchuk O. … Tomarev S. (J. Biol. Chem. 2005) 2 3 23
  3. Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. (PMID: 15123989) Mukhopadhyay A. … Ray K. (Mol. Vis. 2004) 4 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for OLFM3 Gene

Sources for OLFM3 Gene

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