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Aliases & Descriptions for OLFM3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| NOE3 1, 2, 3 | | NOELIN3 2 | | NOELIN3_V1 2 | | NOELIN3_V2 2 | | NOELIN3_V3 2 | | NOELIN3_V4 2 | | NOELIN3_V5 2 | | NOELIN3_V6 2 | | OPTIMEDIN 2 | | OTTHUMP00000012614 2 | | Olfactomedin-3 3 | | Optimedin 3 |
| | | Descriptions |
|---|
| noelin 3 2 | | olfactomedin 3 2 | | olfactomedin related ER localized protein 3 2 |
|
| | Search outside databases for aliases for OLFM3 genePrevious GC identifers: GC01M103097 GC01M101449 GC01M101559 GC01M101731 GC01M101980 |
Summaries for OLFM3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for OLFM3 |
Genomic Location for OLFM3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OLFM3 gene 
Entrez Gene cytogenetic band: 1p22 Ensembl cytogenetic band: 1p21.1 HGNC cytogenetic band: 1p22OLFM3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M102040:
(about GC identifiers)
Start:
|
102,040,718 bp from pter |
End:
|
102,235,136 bp from pter |
Size:
|
194,419 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for OLFM3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NOE3_HUMAN, Q96PB7 (See
protein sequence)Recommended Name: Noelin-3 precursor Size: 478 amino acids; 54930 Da
Subunit: Homodimer. Interacts with MYOC (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: Q6IMI8 Q8TBG1 Q96PB2 Q96PB3 Q96PB4 Q96PB5 Q96PB6Alternative splicing: 6 isoforms: Q96PB7-1 Q96PB7-2 Q96PB7-3 Q96PB7-4 Q96PB7-5 Q96PB7-6 REFSEQ proteins: NP_477518.2
ENSEMBL proteins: ENSP00000359121 ENSP00000345192 ENSP00000352867
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: OLFM3 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | About this table
Antibodies for OLFM3: Assays for OLFM3: | Protein
Domains/ Families for OLFM3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96PB7
ProtoNet protein and cluster: Q96PB7 1 Blocks protein family: IPB003112 Olfactomedin-like
UniProtKB/Swiss-Prot: NOE3_HUMAN, Q96PB7Similarity: Contains 1 olfactomedin-like domain | Gene Function for OLFM3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_058170
Applied Biosystems Silencer® siRNAs for OLFM3
Sigma-Aldrich siRNA for OLFM3  Sigma-Aldrich shRNA for OLFM3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_058170                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_058170                                  untagged cDNA clone in CMV expression vector: NM_058170 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_058170
| Pathways & Interactions for OLFM3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for OLFM3 
4 Interacting proteins for OLFM3 (ENSP000003451923) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for OLFM3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for OLFM3
|
Transcripts for OLFM3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_058170
Sigma-Aldrich siRNA for OLFM3  Sigma-Aldrich shRNA for OLFM3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_058170 REFSEQ mRNAs for OLFM3 gene: NM_058170.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_058170               OriGene GFP tagged cDNA clone in CMV expression vector: NM_058170                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_058170                                  untagged cDNA clone in CMV expression vector: NM_058170  Additional cDNA sequence: AF397392.2 AF397393.2 AF397394.1 AF397395.1 AF397396.1 AF397397.1 AK095551.1 AK095724.1 AK300870.1 AY358722.1 BC022531.1 CR604928.1 5 DOTS entries: DT.91980055 DT.97839269 DT.97839270 DT.40251502 DT.100649955 21 AceView cDNA sequences:BX280329 AK095551 BX507629 BX410220 CR604928 AK095724 BC022531 AA332351 BX453761 CF786013 AV723943 BX353091 BG699452 AY358722 BI916534 AW103607 BI668938 BI757150 AA747514 BM805809 BX422938
highest scoring ESTs for OLFM3:AA332351 AK095724 BC022531 BG699452 BI668938 BI757150 BI916534 BM805809 BX280329 BX507629 Unigene Cluster for OLFM3: Olfactomedin 3 Hs.484475 [show with all ESTs]Unigene Representative Sequence: NM_058170
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for OLFM3
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | |
| SP1: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for OLFM3
3 Ensembl transcripts including schematic representations: ENST00000370103
ENST00000338858
ENST00000359814
|
Expression for OLFM3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OLFM3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OLFM3
1 / 2 2 probe-sets matching OLFM3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TAAAGAAATC
SOURCE GeneReport for Unigene cluster: Hs.484475 UniProtKB/Swiss-Prot: NOE3_HUMAN, Q96PB7Tissue specificity: In the eye, expressed in trabecular meshwork and neural retina; in non-ocular tissues, expressed in brain and lung |
Orthologs for OLFM3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OLFM3 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for OLFM3
ENSEMBL Gene Tree for OLFM3 | Paralogs for OLFM3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for OLFM3 gene
- MYOC2 OLFM12 OLFM22
|
SNPs/Variants for OLFM3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OLFM3 (up to first 250kb)
|
Disorders & Mutations for OLFM3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607567
Human Genome Epidemiology Navigator: OLFM3 (1 document)
|
Medical News for OLFM3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OLFM3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for OLFM3 gene (see all 13
):- Optimedin: a novel olfactomedin-related protein that interacts with myocilin. (PubMed id 12019210)1, 2, 3, 4 Torrado M.... Tomarev S.I. (2002)
- The Optimedin gene is a downstream target of Pax6. (PubMed id 16115881)1, 2, 3 Grinchuk O....Tomarev S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. (PubMed id 15123989)1, 4 Mukhopadhyay A.... Ray K. (2004)
- Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)3 Uhl G.R....Lerman C. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )4 Aoki H.... Hino O. (2000)
|
Search for OLFM3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OLFM3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OLFM3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OLFM3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for OLFM3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OLFM3:

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Incremental update: 13 Oct 2009
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