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OLFM3 Gene

protein-coding   GIFtS: 51

GC01M102040
olfactomedin 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
NOE3 1, 2, 3
NOELIN3 2
NOELIN3_V1 2
NOELIN3_V2 2
NOELIN3_V3 2
NOELIN3_V4 2
NOELIN3_V5 2
NOELIN3_V6 2
OPTIMEDIN 2
OTTHUMP00000012614 2
Olfactomedin-3 3
Optimedin 3
Descriptions
noelin 3 2
olfactomedin 3 2
olfactomedin related ER localized protein 3 2
External Ids
HGNC: 179901
Entrez Gene: 1184272
UniProtKB: Q96PB73
Ensembl: ENSG000001187337
Search outside databases for aliases for OLFM3 gene

Previous GC identifers: GC01M103097 GC01M101449 GC01M101559 GC01M101731 GC01M101980

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for OLFM3
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OLFM3 gene  

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p21.1   HGNC cytogenetic band: 1p22

OLFM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M102040:     (about GC identifiers)

Start:
102,040,718 bp from pter
End:
102,235,136 bp from pter
Size:
194,419 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NOE3_HUMAN, Q96PB7 (See protein sequence)
Recommended Name: Noelin-3 precursor  
Size: 478 amino acids; 54930 Da
Subunit: Homodimer. Interacts with MYOC (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: Q6IMI8 Q8TBG1 Q96PB2 Q96PB3 Q96PB4 Q96PB5 Q96PB6
Alternative splicing: 6 isoforms:  Q96PB7-1   Q96PB7-2   Q96PB7-3   Q96PB7-4   Q96PB7-5   Q96PB7-6   

REFSEQ proteins: NP_477518.2  

ENSEMBL proteins: 
ENSP00000359121 ENSP00000345192 ENSP00000352867 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Optimedin)
Human Recombinant Proteins from Abnova (OLFM3)
              OriGene Purified Recombinant Human Protein: OLFM3 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
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Antibodies for OLFM3: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for OLFM3
Browse R&D Systems for Antibodies
Antibodies from Abcam (Optimedin), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (OLFM3)
Novus Biologicals Antibodies for OLFM3

Assays for OLFM3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR003112 Olfac-like


   GeneDecks  OLFM3 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q96PB7

ProtoNet protein and cluster: Q96PB7

1 Blocks protein family: IPB003112 Olfactomedin-like

UniProtKB/Swiss-Prot: NOE3_HUMAN, Q96PB7
Similarity: Contains 1 olfactomedin-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OLFM3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OLFM3)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_058170

              Applied Biosystems Silencer® siRNAs for OLFM3

              Sigma-Aldrich siRNA for OLFM3  
                     Sigma-Aldrich shRNA for OLFM3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_058170
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_058170
                                 untagged cDNA clone in CMV expression vector: NM_058170 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_058170

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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 Gene Network CentralTM Interacting Genes and Proteins Network for  OLFM3 


4 Interacting proteins for OLFM3 (ENSP000003451923) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
PAX6ENSP000003684243STRING (score=.962)
OPTNENSP000003680223STRING (score=.779)
CYP1B1ENSP000002606303STRING (score=.701)
MYOCENSP000000375023STRING (score=.7)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OLFM3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OLFM3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OLFM3)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_058170

              Sigma-Aldrich siRNA for OLFM3  
                     Sigma-Aldrich shRNA for OLFM3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_058170  

REFSEQ mRNAs for OLFM3 gene: 

NM_058170.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_058170  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_058170
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_058170
                                 untagged cDNA clone in CMV expression vector: NM_058170 

Additional cDNA sequence: 

AF397392.2 AF397393.2 AF397394.1 AF397395.1 AF397396.1 AF397397.1 AK095551.1 AK095724.1 
AK300870.1 AY358722.1 BC022531.1 CR604928.1 

5 DOTS entries:

DT.91980055  DT.97839269  DT.97839270  DT.40251502  DT.100649955 

21 AceView cDNA sequences:

BX280329 AK095551 BX507629 BX410220 CR604928 AK095724 BC022531 AA332351 
BX453761 CF786013 AV723943 BX353091 BG699452 AY358722 BI916534 AW103607 
BI668938 BI757150 AA747514 BM805809 BX422938 

highest scoring ESTs for OLFM3:

AA332351 AK095724 BC022531 BG699452 BI668938 BI757150 BI916534 BM805809 BX280329 BX507629 

Unigene Cluster for OLFM3:

Olfactomedin 3
Hs.484475  [show with all ESTs]
Unigene Representative Sequence: NM_058170


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for OLFM3

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:                          -     -     -                                       
SP2:                                      -                                       
SP3:                    -     -     -     -                                       
SP4:                                -                                             
SP5:                    -     -     -                                             

About this scheme

ECgene alternative splicing isoforms for OLFM3

3 Ensembl transcripts including schematic representations:
ENST00000370103  ENST00000338858  ENST00000359814  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OLFM3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OLFM3

1 / 2

2 probe-sets matching OLFM3 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1554524_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1554526_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TAAAGAAATC

SOURCE GeneReport for Unigene cluster: Hs.484475

UniProtKB/Swiss-Prot: NOE3_HUMAN, Q96PB7
Tissue specificity: In the eye, expressed in trabecular meshwork and neural retina; in non-ocular
tissues, expressed in brain and lung

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for OLFM3 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
OLFM31   -- olfactomedin 3 91.61(n)
96.28(a)
490137  XM_547258.2  XP_547258.2 
chimpanzee
(Pan troglodytes)
OLFM31   -- olfactomedin 3 96.72(n)
96.5(a)
457064  XM_001139312.1  XP_001139312.1 
cow
(Bos taurus)
OLFM31   -- olfactomedin 3 91.25(n)
95.84(a)
538499  XM_580704.3  XP_580704.3 
rat
(Rattus norvegicus)
Olfm31   -- olfactomedin 3 88.55(n)
95.84(a)
252920  NM_145777.1  NP_665720.1 
mouse
(Mus musculus)
Olfm31, 5 35
olfactomedin 31, 5 88.91(n)1
95.84(a)1
2297591  NM_153157.21  NP_694797.11 
 AF4428245  AF4428255  (see all 16)
About this table        Species with no ortholog for OLFM3

ENSEMBL Gene Tree for OLFM3
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for OLFM3 gene
MYOC2  OLFM12  OLFM22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/1231 NCBI SNPs in OLFM3 are shown (see all 1231 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 532)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs9456421,2
A,C,F,H,O102236102(+) AATTTC/TATTTC 1 -- ng3117Minor allele frequency- T:0.11NS EA NA EU WA 1152
rs11052801,2
C,F,H,O102235327(-) AGTTAA/CTCCCT 1 -- ut5117Minor allele frequency- C:0.17NS EU EA WA NA 2504
rs120793561,2
C,F,H102040399(+) GTACCA/GTATAA 1 -- ng5112Minor allele frequency- N:0.00EA NA EU WA 1022
rs67014951,2
A,C102235849(+) CCAGCC/TGAAAT 1 -- ng310--------
--
rs171254501,2
F102040815(+) AATGTT/CAGGAT 1 -- ut31 ese33Minor allele frequency- C:0.02NA 142
--
rs178566761,2
H102042458(+) AGGCAT/CAGAGA 1 C/Y mis1 ese34Minor allele frequency- C:0.00EU EA WA 412
--
rs120249551,2
A102236195(+) TGCCTG/TTAATA 1 -- ng310--------
--
rs174287611,2
C102041663(+) TATGTA/TAAGGG 1 -- ut31 ese33Minor allele frequency- T:0.01NA 142
rs104939731,2
A,C,F,H102068867(-) GCAAAA/GTTTCG 1 K/K syn120Minor allele frequency- G:0.13NS NA EU EA WA 1500
rs13275941,2
A,C,F,H,O102043417(-) AGGTTA/GTATTT 1 -- int18Minor allele frequency- G:0.40MN NA EU EA WA 744
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HapMap Linkage Disequilibrium images for OLFM3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607567

Human Genome Epidemiology Navigator: OLFM3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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10/13 PubMed articles for OLFM3 gene (see all 13 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 118427 HGNC: 17990 AceView: OLFM3 Ensembl:ENSG00000118733 euGenes: HUgn118427
ECgene: OLFM3 H-InvDB: OLFM3
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OLFM3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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 Predesigned and custom siRNAs for OLFM3 Antibodies for OLFM3
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OLFM3 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
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 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for OLFM3




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for OLFM3

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