Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OLFM3 Gene

protein-coding   GIFtS: 51
GCID: GC01M102268

Olfactomedin 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactomedin 31 2     NOELIN3_V62
NOE32 3     OPTIMEDIN2
optimedin1     Noelin 32
NOELIN32     noelin-32
NOELIN3_V12     Olfactomedin Related ER Localized Protein 32
NOELIN3_V22     olfactomedin-32
NOELIN3_V32     Olfactomedin-33
NOELIN3_V42     Optimedin3
NOELIN3_V52     

External Ids:    HGNC: 179901   Entrez Gene: 1184272   Ensembl: ENSG000001187337   OMIM: 6075675   UniProtKB: Q96PB73   

Export aliases for OLFM3 gene to outside databases

Previous GC identifers: GC01M103097 GC01M101449 GC01M101559 GC01M101731 GC01M101980 GC01M102040 GC01M100394


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OLFM3 Gene: 
OLFM3 (olfactomedin 3) is a protein-coding gene. Diseases associated with OLFM3 include glaucoma. An important paralog of this gene is GLDN.

Gene Wiki entry for OLFM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OLFM3 gene promoter:
         Pbx1a   NRSF form 1   CUTL1   NRSF form 2   S8   CBF-B   CBF-A   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOLFM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for OLFM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLFM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p21.1   HGNC cytogenetic band: 1p22

OLFM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLFM3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M102268:  view genomic region     (about GC identifiers)

Start:
102,268,127 bp from pter      End:
102,462,790 bp from pter
Size:
194,664 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOE3_HUMAN, Q96PB7 (See protein sequence)
Recommended Name: Noelin-3 precursor  
Size: 478 amino acids; 54930 Da
Subunit: Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4
pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a
twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2,
CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is
complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the
interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2,
CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more
peripherally associated AMPAR constituents, including OLFM3. Alone or in combination, these auxiliary subunits
control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein
processing. Homodimer. Interacts with MYOC (By similarity)
Subcellular location: Secreted (By similarity). Cell junction, synapse (By similarity)
Secondary accessions: Q5T3V6 Q6IMI7 Q6IMI8 Q6IMI9 Q6IMJ1 Q8TBG1 Q96PB2 Q96PB3 Q96PB4 Q96PB5
Q96PB6
Alternative splicing: 6 isoforms:  Q96PB7-1   Q96PB7-2   Q96PB7-3   Q96PB7-4   Q96PB7-5   Q96PB7-6   

Explore the universe of human proteins at neXtProt for OLFM3: NX_Q96PB7

Explore proteomics data for OLFM3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96PB7

  • OLFM3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OLFM3 Protein Expression
    REFSEQ proteins: NP_477518.2  
    ENSEMBL proteins: 
     ENSP00000359121   ENSP00000345192   ENSP00000352867   ENSP00000443471  

    Human Recombinant Protein Products for OLFM3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for OLFM3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for OLFM3
    GenScript Custom Purified and Recombinant Proteins Services for OLFM3
    Novus Biologicals OLFM3 Proteins
    Novus Biologicals OLFM3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OLFM3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0030054cell junction IEA--
    GO:0032281alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA--
    GO:0045202synapse IEA--

    OLFM3 for ontologies           About GeneDecksing



    OLFM3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for OLFM3
    GenScript Custom Superior Antibodies Services for OLFM3
    Novus Biologicals OLFM3 Antibodies
    Abcam antibodies for OLFM3
    Cloud-Clone Corp. Antibodies for OLFM3 
    ThermoFisher Antibodies for OLFM3
    Search LSBio for Antibodies for OLFM3 

    Assay Products for OLFM3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OLFM3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OLFM3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OLFM3 
    Cloud-Clone Corp. CLIAs for OLFM3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR022082 Noelin-1
     IPR003112 Olfac-like

    Graphical View of Domain Structure for InterPro Entry Q96PB7

    ProtoNet protein and cluster: Q96PB7

    1 Blocks protein domain: IPB003112 Olfactomedin-like

    UniProtKB/Swiss-Prot: NOE3_HUMAN, Q96PB7
    Similarity: Contains 1 olfactomedin-like domain


    OLFM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    OLFM3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Olfm3 (no phenotypes)

    OLFM3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Olfm3tm1Lex for OLFM3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OLFM3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OLFM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OLFM3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OLFM3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OLFM3
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate OLFM3 (see all 36):
    hsa-miR-345 hsa-miR-520f hsa-miR-513a-5p hsa-let-7a-2* hsa-miR-3921 hsa-miR-570 hsa-miR-374a* hsa-miR-409-5p
    SwitchGear 3'UTR luciferase reporter plasmidOLFM3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OLFM3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OLFM3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OLFM3
    Sirion Biotech Customized adenovirus for overexpression of OLFM3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for OLFM3 (see all 8)
    OriGene ORF clones in mouse, rat for OLFM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OLFM3 (NM_058170)
    Sino Biological Human cDNA Clone for OLFM3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OLFM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLFM3
    Sirion Biotech Customized lentivirus for stable overexpression of OLFM3 
                         Customized lentivirus expression plasmids for stable overexpression of OLFM3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OLFM3
    Search LifeMap BioReagents cell lines for OLFM3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFM3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OLFM3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for OLFM3 (Q96PB73 ENSP000003591214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOCQ999723, ENSP000000375024I2D: score=3 STRING: ENSP00000037502
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042462eye photoreceptor cell development IEA--

    OLFM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OLFM3 (NOE3)

    Search CenterWatch for drugs/clinical trials and news about OLFM3 / NOE3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OLFM3 gene: 
    NM_058170.2  

    Unigene Cluster for OLFM3:

    Olfactomedin 3
    Hs.484475  [show with all ESTs]
    Unigene Representative Sequence: NM_058170
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370103(uc001due.2 uc001duf.2 uc001dug.2 uc001duh.2 uc001dui.2 uc001duj.2)
    ENST00000338858 ENST00000465523 ENST00000462354 ENST00000468901 ENST00000359814
    ENST00000536598
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OLFM3
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate OLFM3 (see all 36):
    hsa-miR-345 hsa-miR-520f hsa-miR-513a-5p hsa-let-7a-2* hsa-miR-3921 hsa-miR-570 hsa-miR-374a* hsa-miR-409-5p
    SwitchGear 3'UTR luciferase reporter plasmidOLFM3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OLFM3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OLFM3
    Clone
    Products:
         
    OriGene clones in human, mouse for OLFM3 (see all 8)
    OriGene ORF clones in mouse, rat for OLFM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OLFM3 (NM_058170)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OLFM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLFM3
    Sirion Biotech Customized lentivirus for stable overexpression of OLFM3 
                         Customized lentivirus expression plasmids for stable overexpression of OLFM3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OLFM3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OLFM3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLFM3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLFM3

    Additional mRNA sequence: 

    AF397392.2 AF397393.2 AF397394.1 AF397395.1 AF397396.1 AF397397.1 AK095551.1 AK095724.1 
    AK300870.1 AY358722.1 BC022531.1 

    5 DOTS entries:

    DT.91980055  DT.97839269  DT.97839270  DT.40251502  DT.100649955 

    21 AceView cDNA sequences:

    CR604928 AK095724 AK095551 BX280329 BX410220 BX507629 BX353091 AY358722 
    BG699452 AV723943 BI916534 CF786013 BC022531 AA332351 BX453761 BI668938 
    BI757150 AW103607 AA747514 BM805809 BX422938 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for OLFM3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                          -     -     -                                       
    SP2:                                      -                                       
    SP3:                    -     -     -     -                                       
    SP4:                                -                                             
    SP5:                    -     -     -                                             


    ECgene alternative splicing isoforms for OLFM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OLFM3 expression in normal human tissues (normalized intensities)      OLFM3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAGAAATC
    OLFM3 Expression
    About this image


    OLFM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Breast (Uncategorized)
             MAMMARY GLAND   
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Brain (Nervous System)

    See OLFM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OLFM3

    SOURCE GeneReport for Unigene cluster: Hs.484475

    UniProtKB/Swiss-Prot: NOE3_HUMAN, Q96PB7
    Tissue specificity: In the eye, expressed in trabecular meshwork and neural retina; in non-ocular tissues,
    expressed in brain and lung

        SABiosciences Custom PCR Arrays for OLFM3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OLFM3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OLFM3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLFM3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLFM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OLFM3 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfm31 , 5 olfactomedin 31, 5 91.05(n)1
    98.47(a)1
      3 (49.43 cM)5
    2297591  NM_153458.21  NP_703188.11 
     1149040785 
    chicken
    (Gallus gallus)
    Aves OLFM31 olfactomedin 3 84.83(n)
    95.4(a)
      424461  XM_422304.3  XP_422304.3 
    lizard
    (Anolis carolinensis)
    Reptilia OLFM36
    olfactomedin 3
    98(a)
    1 ↔ 1
    4(86769476-86975320)
    zebrafish
    (Danio rerio)
    Actinopterygii olfm3a1 olfactomedin 3a 74.37(n)
    85.11(a)
      563182  NM_001111172.1  NP_001104642.1 


    ENSEMBL Gene Tree for OLFM3 (if available)
    TreeFam Gene Tree for OLFM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OLFM3 gene
    GLDN2  OLFML32  OLFML2A2  OLFM12  OLFM42  OLFM22  MYOC2  OLFML2B2  
    OLFML12  
    7 SIMAP similar genes for OLFM3 using alignment to 2 protein entries:     NOE3_HUMAN (see all proteins):
    OLFM1    OLFM2    OLFML2B    FLJ00237    MYOC    LPHN2
    LPHN3

    OLFM3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3693 SNPs in OLFM3 are shown (see all 3693)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs574796031,2
    C--100543729(+) ACCTA-/TCTA  
            
    ACTAT
    1 -- int11Minor allele frequency- TCTA:0.00NA 2
    rs601734881,2
    C--100558035(+) GTGTG-/TGTGCG/
    TGTGTGTGCG
    CTACA
    1 -- int12NA 4
    rs1126201251,2
    C,F--102267683(+) TTGCTC/TTAGCA 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs120793561,2
    C,F,H--102267811(+) GTACCA/GTATAA 1 -- ds500129Minor allele frequency- N:0.00EA NA NS WA 2978
    rs1479440181,2
    C--102267943(+) AGACTG/TGTTGT 1 -- ds50010--------
    rs1418655761,2
    --102268033(+) CGTTAA/TAAAAA 1 -- ds50010--------
    rs171254501,2
    C,F--102268227(+) AATGTT/CAGGAT 1 -- ut31 ese34Minor allele frequency- C:0.04NA WA 260
    rs1503931111,2
    --102268259(+) TAAATC/TATTAC 1 -- ut310--------
    rs1381589441,2
    --102268347(+) ATTATA/TGAATA 1 -- ut310--------
    rs1491583971,2
    --102268351(+) TAGAAC/TATACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OLFM3 (102268127 - 102462790 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for OLFM3 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670818CNV Deletion23128226
    esv2422183CNV Deletion17116639
    esv2673123CNV Deletion23128226
    nsv2143CNV Insertion18451855
    nsv520768CNV Loss19592680
    nsv508026CNV Loss20534489
    nsv522921CNV Loss19592680
    dgv276n71CNV Gain21882294
    nsv522156CNV Gain19592680
    nsv441701CNV CNV18776908

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OLFM3
    DNA2.0 Custom Variant and Variant Library Synthesis for OLFM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607567    OMIM disorders: --

    2 diseases for OLFM3:    About MalaCards
    glaucoma    


    OLFM3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OLFM3
    Human Genome Epidemiology (HuGE) Navigator: OLFM3 (2 documents)

    Export disorders for OLFM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OLFM3 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with OLFM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Optimedin: a novel olfactomedin-related protein that interacts with myocilin. (PubMed id 12019210)1, 2, 3, 9 Torrado M.... Tomarev S.I. (2002)
    2. The Optimedin gene is a downstream target of Pax6. (PubMed id 16115881)1, 3, 9 Grinchuk O....Tomarev S. (2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. (PubMed id 15123989)2, 9 Mukhopadhyay A.... Ray K. (2004)
    9. Olfactomedin III expression contributes to anoikis-res istance in clonal variants of a human lung squamous carcinoma cell line. (PubMed id 22281030)1 Keenan J....Clynes M. (2012)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 118427 HGNC: 17990 AceView: OLFM3 Ensembl:ENSG00000118733 euGenes: HUgn118427
    ECgene: OLFM3 H-InvDB: OLFM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OLFM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OLFM3 gene:
    Search GeneIP for patents involving OLFM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OLFM3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for OLFM3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for OLFM3  
     OriGene qSTAR qPCR primer pairs in human, mouse for OLFM3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for OLFM3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OLFM3   OriGene Custom Protein Services for OLFM3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OLFM3
     QIAGEN SeqTarget long-range PCR primers for resequencing OLFM3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLFM3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OLFM3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLFM3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLFM3
     GenScript Custom Purified and Recombinant Proteins Services for OLFM3 GenScript cDNA clones with any tag delivered in your preferred vector for OLFM3
     GenScript Custom Assay Services for OLFM3 GenScript Custom Superior Antibodies Services for OLFM3
     GenScript Custom overexpressing Cell Line Services for OLFM3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in OLFM3 promoter
     Search Chromatin IP Primers for OLFM3
     RT2 qPCR Primer Assay in human, mouse, rat OLFM3
     GNC Network for OLFM3
     SABiosciences Custom PCR Arrays for OLFM3
     Search Tocris compounds for OLFM3 (NOE3)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for OLFM3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     OLFM3 antibodies
     OLFM3 proteins
     OLFM3 lysates
     Antibodies for OLFM3
     See all of Abcam's Antibodies, Kits and Proteins for OLFM3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for OLFM3
     Antibodies for OLFM3
     ELISAs for OLFM3
     CLIAs for OLFM3
     Search LifeMap BioReagents cell lines for OLFM3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFM3
     SwitchGear 3'UTR luciferase reporter plasmids for OLFM3
     SwitchGear Promoter luciferase reporter plasmids for OLFM3
     ThermoFisher Antibodies for OLFM3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLFM3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for OLFM3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OLFM3
    Customized:
     lentivirus for stable overexpression of OLFM3
     lentivirus expression plasmids for stable overexpression of OLFM3
     adenovirus for overexpression of OLFM3
     Search LSBio for Antibodies for OLFM3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OLFM3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4