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Aliases for OLFM2 Gene

Aliases for OLFM2 Gene

  • Olfactomedin 2 2 3
  • Olfactomedin-2 3 4
  • NOE2 3 4
  • Neuronal Olfactomedin Related ER Localized Protein 2 3
  • NOELIN2_V1 3
  • Noelin 2 2
  • Noelin-2 3
  • NOELIN2 3
  • OlfC 3

External Ids for OLFM2 Gene

Previous GeneCards Identifiers for OLFM2 Gene

  • GC19M010085
  • GC19M010187
  • GC19M009809
  • GC19M009825
  • GC19M009964
  • GC19M009545

Summaries for OLFM2 Gene

GeneCards Summary for OLFM2 Gene

OLFM2 (Olfactomedin 2) is a Protein Coding gene. An important paralog of this gene is GLDN.

Gene Wiki entry for OLFM2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFM2 Gene

Genomics for OLFM2 Gene

Regulatory Elements for OLFM2 Gene

Genomic Location for OLFM2 Gene

9,853,718 bp from pter
9,936,552 bp from pter
82,835 bases
Minus strand

Genomic View for OLFM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLFM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFM2 Gene

Proteins for OLFM2 Gene

  • Protein details for OLFM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6IMJ3
    • Q96FC2

    Protein attributes for OLFM2 Gene

    454 amino acids
    Molecular mass:
    51386 Da
    Quaternary structure:
    • Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

neXtProt entry for OLFM2 Gene

Proteomics data for OLFM2 Gene at MOPED

Post-translational modifications for OLFM2 Gene

  • Glycosylation at Asn74, Asn155, Asn275, Asn310, Asn399, and Asn441
  • Modification sites at PhosphoSitePlus

Other Protein References for OLFM2 Gene

No data available for DME Specific Peptides for OLFM2 Gene

Domains for OLFM2 Gene

Protein Domains for OLFM2 Gene


Suggested Antigen Peptide Sequences for OLFM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 olfactomedin-like domain.
  • Contains 1 olfactomedin-like domain.
genes like me logo Genes that share domains with OLFM2: view

No data available for Gene Families for OLFM2 Gene

Function for OLFM2 Gene

Gene Ontology (GO) - Molecular Function for OLFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with OLFM2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLFM2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OLFM2 Gene

Localization for OLFM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFM2 Gene

Secreted. Cell junction, synapse.

Subcellular locations from

Jensen Localization Image for OLFM2 Gene COMPARTMENTS Subcellular localization image for OLFM2 gene
Compartment Confidence
extracellular 4
lysosome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OLFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 21228389
GO:0030054 cell junction IEA --
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with OLFM2: view

Pathways for OLFM2 Gene

SuperPathways for OLFM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IDA 21228389
genes like me logo Genes that share ontologies with OLFM2: view

No data available for Pathways by source for OLFM2 Gene

Transcripts for OLFM2 Gene

Unigene Clusters for OLFM2 Gene

Olfactomedin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLFM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for OLFM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OLFM2 Gene

mRNA expression in normal human tissues for OLFM2 Gene

mRNA differential expression in normal tissues according to GTEx for OLFM2 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (4.5), Brain - Amygdala (4.1), and Brain - Nucleus accumbens (basal ganglia) (4.0).

Protein differential expression in normal tissues for OLFM2 Gene

This gene is overexpressed in Vitreous humor (47.3) and Serum (16.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OLFM2 Gene

SOURCE GeneReport for Unigene cluster for OLFM2 Gene Hs.169743

genes like me logo Genes that share expressions with OLFM2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for OLFM2 Gene

Orthologs for OLFM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OLFM2 35
  • 92.35 (n)
  • 98.64 (a)
OLFM2 36
  • 96 (a)
(Canis familiaris)
Mammalia OLFM2 35
  • 93.09 (n)
  • 98.16 (a)
OLFM2 36
  • 98 (a)
(Mus musculus)
Mammalia Olfm2 35
  • 88.23 (n)
  • 97.48 (a)
Olfm2 16
Olfm2 36
  • 95 (a)
(Pan troglodytes)
Mammalia OLFM2 35
  • 99.41 (n)
  • 99.78 (a)
OLFM2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Olfm2 35
  • 88.38 (n)
  • 97.92 (a)
(Monodelphis domestica)
Mammalia OLFM2 36
  • 88 (a)
(Anolis carolinensis)
Reptilia OLFM2 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia olfm2 35
  • 73.98 (n)
  • 82.68 (a)
(Danio rerio)
Actinopterygii Dr.10562 35
olfm2a 35
  • 73.36 (n)
  • 78.06 (a)
olfm2b 36
  • 49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.278 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for OLFM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFM2 Gene

Gene Tree for OLFM2 (if available)
Gene Tree for OLFM2 (if available)

Paralogs for OLFM2 Gene

Paralogs for OLFM2 Gene

(9) SIMAP similar genes for OLFM2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OLFM2: view

Variants for OLFM2 Gene

Sequence variations from dbSNP and Humsavar for OLFM2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs889122 -- 9,885,191(-) CACTA(A/C)TATCA intron-variant
rs889123 -- 9,885,167(-) GGTGG(A/G)GAAAG intron-variant
rs889124 -- 9,885,104(-) AAGCC(A/G)GGTTT intron-variant
rs918538 -- 9,903,187(-) GCCAG(G/T)TGCAG intron-variant
rs918539 -- 9,903,164(-) ATTAT(C/G)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFM2 Gene

Variant ID Type Subtype PubMed ID
nsv520683 CNV Loss 19592680
nsv833742 CNV Loss 17160897
esv2656960 CNV Deletion 23128226

Relevant External Links for OLFM2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFM2 Gene

Disorders for OLFM2 Gene

(1) University of Copenhagen DISEASES for OLFM2 Gene

Relevant External Links for OLFM2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with OLFM2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for OLFM2 Gene

Publications for OLFM2 Gene

  1. Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. (PMID: 15123989) Mukhopadhyay A. … Ray K. (Mol. Vis. 2004) 3 4 23
  2. SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma. (PMID: 17122126) Funayama T. … Shimada N. (Invest. Ophthalmol. Vis. Sci. 2006) 3 23 48
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 48

Products for OLFM2 Gene

Sources for OLFM2 Gene

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