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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OLFM2 Gene

protein-coding   GIFtS: 57
GCID: GC19M009964

Olfactomedin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactomedin 21 2     OlfC2
Noelin 21 2     Neuronal Olfactomedin Related ER Localized Protein 22
NOE22 3     noelin-22
NOELIN22     olfactomedin-22
NOELIN2_V12     Olfactomedin-23

External Ids:    HGNC: 171891   Entrez Gene: 931452   Ensembl: ENSG000001050887   UniProtKB: O958973   

Export aliases for OLFM2 gene to outside databases

Previous GC identifers: GC19M010085 GC19M010187 GC19M009809 GC19M009825 GC19M009545


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OLFM2 Gene: 
OLFM2 (olfactomedin 2) is a protein-coding gene. Diseases associated with OLFM2 include open-angle glaucoma, and glaucoma. An important paralog of this gene is GLDN.

Gene Wiki entry for OLFM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OLFM2 gene promoter:
         Max   Bach1   ER-alpha   USF1   USF-1   Bach2   USF2   USF-1:USF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOLFM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OLFM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLFM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

OLFM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLFM2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M009964:  view genomic region     (about GC identifiers)

Start:
9,964,394 bp from pter      End:
10,047,228 bp from pter
Size:
82,835 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOE2_HUMAN, O95897 (See protein sequence)
Recommended Name: Noelin-2 precursor  
Size: 454 amino acids; 51386 Da
Subunit: Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4
pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a
twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2,
CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is
complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the
interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2,
CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more
peripherally associated AMPAR constituents, including OLFM2. Alone or in combination, these auxiliary subunits
control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein
processing (By similarity)
Subcellular location: Secreted (Probable). Cell junction, synapse (By similarity)
Secondary accessions: Q6IMJ3 Q96FC2

Explore the universe of human proteins at neXtProt for OLFM2: NX_O95897

Explore proteomics data for OLFM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95897

  • OLFM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OLFM2 Protein Expression
    REFSEQ proteins: NP_477512.1  
    ENSEMBL proteins: 
     ENSP00000264833   ENSP00000464877   ENSP00000466018   ENSP00000465809  

    Human Recombinant Protein Products for OLFM2: 
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    Cloud-Clone Corp. Proteins for OLFM2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA--
    GO:0030054cell junction IEA--
    GO:0032281alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA--
    GO:0045202synapse IEA--

    OLFM2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR022082 Noelin-1
     IPR003112 Olfac-like

    Graphical View of Domain Structure for InterPro Entry O95897

    ProtoNet protein and cluster: O95897

    1 Blocks protein domain: IPB003112 Olfactomedin-like

    UniProtKB/Swiss-Prot: NOE2_HUMAN, O95897
    Similarity: Contains 1 olfactomedin-like domain


    OLFM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    OLFM2 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OLFM2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/15 Interacting proteins for OLFM2 (O958972, 3 ENSP000002648334) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ST13P505022, 3MINT-63324 I2D: score=5 
    FANCFQ9NPI82, 3MINT-63328 I2D: score=4 
    GNB5O147752, 3MINT-63321 I2D: score=4 
    NBASA2RRP12, 3MINT-63329 I2D: score=4 
    PKMP146182, 3MINT-63322 I2D: score=4 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009306protein secretion IDA--

    OLFM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OLFM2 (NOE2)

    Search CenterWatch for drugs/clinical trials and news about OLFM2 / NOE2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OLFM2 gene: 
    NM_058164.2  

    Unigene Cluster for OLFM2:

    Olfactomedin 2
    Hs.169743  [show with all ESTs]
    Unigene Representative Sequence: BM920627
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264833(uc002mmp.3) ENST00000590841 ENST00000592448 ENST00000593091
    ENST00000590410
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate OLFM2:
    hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidOLFM2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLFM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLFM2

    Additional mRNA sequence: 

    AF131839.1 BC011361.1 

    4 DOTS entries:

    DT.437658  DT.95071875  DT.91707321  DT.100837294 

    24/114 AceView cDNA sequences (see all 114):

    CR604836 CR598222 AW962045 C00947 AI834308 AW273242 CR592581 R40423 
    CR606369 CR612883 T04866 BM554133 AI902497 CR592038 BM479224 CR597123 
    CR594920 BE252295 BQ428091 BF526894 BX437232 AA324877 BI917371 BM928290 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OLFM2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:              -                       -                           
    SP2:                                      -                           
    SP3:                                -     -                           
    SP4:              -                                                   


    ECgene alternative splicing isoforms for OLFM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OLFM2 expression in normal human tissues (normalized intensities)      OLFM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTGTTTC
    OLFM2 Expression
    About this image


    OLFM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Adipose (Muscoskeletal System)
             adipose tissue   
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived mesenchymal stem cells
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Umbilical cord blood-derived mesenchymal stem cells
     
     Brain (Nervous System)
             amygdala   

    See OLFM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OLFM2

    SOURCE GeneReport for Unigene cluster: Hs.169743
        SABiosciences Custom PCR Arrays for OLFM2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OLFM2 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfm21 , 5 olfactomedin 21, 5 88.35(n)1
    97.7(a)1
      9 (7.60 cM)5
    2447231  NM_173777.31  NP_776138.21 
     206679865 
    lizard
    (Anolis carolinensis)
    Reptilia OLFM26
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343198.1(5062063-5290347)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.105622 Danio rerio mRNA similar to olfactomedin 2 (cDNA clone more 76.73(n)    BC044164.1 


    ENSEMBL Gene Tree for OLFM2 (if available)
    TreeFam Gene Tree for OLFM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OLFM2 gene
    GLDN2  OLFM32  OLFML32  OLFML2A2  OLFM12  OLFM42  MYOC2  OLFML2B2  
    OLFML12  
    9 SIMAP similar genes for OLFM2 using alignment to 5 protein entries:     NOE2_HUMAN (see all proteins):
    OLFM1    OLFM3    OLFML2B    FLJ00237    OLFML2A    MYOC
    LPHN3    LPHN2    LPHN1

    OLFM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1762 SNPs in OLFM2 are shown (see all 1762)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365324
    A colorectal cancer sample4--see VAR_0365322 T M mis40--------
    rs573305691,2
    C--9560290(+) TTTTT-/T/TT  
            
    GGCAA
    1 -- int11NA 2
    rs589245771,2
    C--9585717(+) AATAA-/ATAATAAT/TA/
    TAATA
    /TAATAATAA
    ATAAA
    2 -- int1 cds10--------
    rs343627621,2
    C--9622616(+) GTACT-/GTACT 
            
    CCAGC
    1 -- int11Minor allele frequency- GTACT:0.00NA 2
    rs1874272411,2
    --9629270(+) AGGGCA/GCTGGT 1 -- us2k10--------
    rs1871454321,2
    --9963994(+) CATGCA/CACTGC 1 -- int10--------
    rs345563611,2
    C,F--9964072(+) TCTTAG/ATAATG 1 -- int15Minor allele frequency- A:0.05NA 128
    rs797345981,2
    F--9964161(+) ATTCTC/TGGTTG 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1175857851,2
    F--9964185(+) GCTTTT/CAAACG 1 -- int11Minor allele frequency- C:0.01NA 120
    rs93049771,2
    C,F,A,H--9964372(+) CATTGG/TACACA 1 -- int110Minor allele frequency- T:0.08NS EA NA WA 1208

    HapMap Linkage Disequilibrium report for OLFM2 (9964394 - 10047228 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OLFM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2656960CNV Deletion23128226
    nsv833742CNV Loss17160897
    nsv520683CNV Loss19592680


    Human Gene Mutation Database (HGMD): OLFM2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OLFM2
    DNA2.0 Custom Variant and Variant Library Synthesis for OLFM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for OLFM2:    About MalaCards
    open-angle glaucoma    glaucoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for OLFM2:
    Glaucoma

    OLFM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OLFM2
    Human Genome Epidemiology (HuGE) Navigator: OLFM2 (1 document)

    Export disorders for OLFM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OLFM2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with OLFM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma. (PubMed id 17122126)1, 4, 9 Funayama T....Shimada N. (2006)
    2. Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. (PubMed id 15123989)1, 2, 9 Mukhopadhyay A.... Ray K. (2004)
    3. Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. (PubMed id 12766061)1 Tomarev S.I....Malyukova I. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93145 HGNC: 17189 AceView: OLFM2 Ensembl:ENSG00000105088 euGenes: HUgn93145
    ECgene: OLFM2 H-InvDB: OLFM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OLFM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OLFM2 gene:
    Search GeneIP for patents involving OLFM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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