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Aliases for OLFM2 Gene

Aliases for OLFM2 Gene

  • Olfactomedin 2 2 3 5
  • NOE2 3 4
  • Neuronal Olfactomedin Related ER Localized Protein 2 3
  • Olfactomedin-2 4
  • NOELIN2_V1 3
  • Noelin 2 2
  • Noelin-2 3
  • NOELIN2 3
  • OlfC 3

External Ids for OLFM2 Gene

Previous GeneCards Identifiers for OLFM2 Gene

  • GC19M010085
  • GC19M010187
  • GC19M009809
  • GC19M009825
  • GC19M009964
  • GC19M009545

Summaries for OLFM2 Gene

GeneCards Summary for OLFM2 Gene

OLFM2 (Olfactomedin 2) is a Protein Coding gene. An important paralog of this gene is OLFM3.

UniProtKB/Swiss-Prot for OLFM2 Gene

  • Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity).

Gene Wiki entry for OLFM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFM2 Gene

Genomics for OLFM2 Gene

Regulatory Elements for OLFM2 Gene

Enhancers for OLFM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G009944 1.5 FANTOM5 Ensembl ENCODE 16.7 -9.0 -8979 1.9 PKNOX1 GLIS2 FOS ZNF263 ZNF592 SMARCA4 GLIS1 HNF4A SP7 CTCF OLFM2 ZNF846 COL5A3 ENSG00000267650
GH19G009933 1 ENCODE 14.9 +2.2 2225 0.9 ATF1 SIN3A ARID4B GLIS2 ZNF143 KLF7 SP3 NFYC REST KAT8 ZNF177 OLFM2 LOC100996288 ENSG00000267273 ENSG00000200237 GC19P009927
GH19G009914 1 ENCODE 12.3 +21.8 21759 0.9 HDGF ATF1 ARNT AGO1 SIN3A ZNF48 GLIS2 ZNF143 FOS DEK OLFM2 COL5A3 RDH8 ENSG00000267273 ZNF266 GC19P009927 PIR54152
GH19G009913 0.7 FANTOM5 14.2 +22.6 22576 0.4 CBX3 RNF2 L3MBTL2 ZBTB11 REST ZBTB8A ZNF501 RBBP5 ZBTB7A GLIS2 OLFM2 COL5A3 RDH8 ZNF266 GC19P009927 PIR54152
GH19G009948 0.7 ENCODE 13 -12.3 -12335 0.5 SOX5 SOX13 GATAD2A FOXA2 ZNF384 ZNF781 CEBPA HNF4A NR2F6 NFE2 ZNF177 OLFM2 LOC100996288 ENSG00000267273 ENSG00000200237 ENSG00000267650
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OLFM2 on UCSC Golden Path with GeneCards custom track

Promoters for OLFM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106932 252 601 ZBTB10 MAZ SP3 KLF1 BHLHE40 TSHZ1 MNT ZBTB8A ZNF398 HIC1

Genomic Location for OLFM2 Gene

Chromosome:
19
Start:
9,853,718 bp from pter
End:
9,936,552 bp from pter
Size:
82,835 bases
Orientation:
Minus strand

Genomic View for OLFM2 Gene

Genes around OLFM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFM2 Gene

Proteins for OLFM2 Gene

  • Protein details for OLFM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95897-NOE2_HUMAN
    Recommended name:
    Noelin-2
    Protein Accession:
    O95897
    Secondary Accessions:
    • Q6IMJ3
    • Q96FC2

    Protein attributes for OLFM2 Gene

    Size:
    454 amino acids
    Molecular mass:
    51386 Da
    Quaternary structure:
    • Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Interacts with GRIA2 (By similarity). Interacts with OLFM1 and OLFM3 (PubMed:21228389). Interacts with SRF; the interaction promotes dissociation of SRF from the transcriptional repressor HEY2 (PubMed:25298399).

neXtProt entry for OLFM2 Gene

Post-translational modifications for OLFM2 Gene

  • N-glycosylated.
  • Glycosylation at posLast=7474, posLast=155155, posLast=275275, posLast=310310, Asn399, and posLast=441441
  • Modification sites at PhosphoSitePlus

Other Protein References for OLFM2 Gene

No data available for DME Specific Peptides for OLFM2 Gene

Domains & Families for OLFM2 Gene

Protein Domains for OLFM2 Gene

Suggested Antigen Peptide Sequences for OLFM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OLFM2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OLFM2 Gene

Function for OLFM2 Gene

Molecular function for OLFM2 Gene

UniProtKB/Swiss-Prot Function:
Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity).
UniProtKB/Swiss-Prot Induction:
By TGF-beta.

Gene Ontology (GO) - Molecular Function for OLFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25298399
genes like me logo Genes that share ontologies with OLFM2: view
genes like me logo Genes that share phenotypes with OLFM2: view

Animal Models for OLFM2 Gene

MGI Knock Outs for OLFM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFM2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OLFM2 Gene

Localization for OLFM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFM2 Gene

Secreted. Cell junction, synapse. Membrane. Nucleus. Cytoplasm. Note=Nuclear localization is induced by TGF-beta. {ECO:0000269 PubMed:25298399}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFM2 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 4
lysosome 2
cytosol 1

Gene Ontology (GO) - Cellular Components for OLFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 21228389
GO:0005634 nucleus IEA,IDA 25298399
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 25298399
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OLFM2: view

Pathways & Interactions for OLFM2 Gene

SuperPathways for OLFM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception IEA --
GO:0007626 locomotory behavior IEA --
GO:0009306 protein secretion IDA 21228389
GO:0051152 positive regulation of smooth muscle cell differentiation IMP 25298399
genes like me logo Genes that share ontologies with OLFM2: view

No data available for Pathways by source and SIGNOR curated interactions for OLFM2 Gene

Drugs & Compounds for OLFM2 Gene

No Compound Related Data Available

Transcripts for OLFM2 Gene

Unigene Clusters for OLFM2 Gene

Olfactomedin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for OLFM2 Gene

GeneLoc Exon Structure for
OLFM2
ECgene alternative splicing isoforms for
OLFM2

Expression for OLFM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLFM2 Gene

mRNA differential expression in normal tissues according to GTEx for OLFM2 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.5), Brain - Amygdala (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for OLFM2 Gene

This gene is overexpressed in Vitreous humor (47.3) and Serum (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OLFM2 Gene



NURSA nuclear receptor signaling pathways regulating expression of OLFM2 Gene:

OLFM2

SOURCE GeneReport for Unigene cluster for OLFM2 Gene:

Hs.169743

mRNA Expression by UniProt/SwissProt for OLFM2 Gene:

O95897-NOE2_HUMAN
Tissue specificity: Expressed in aortic smooth muscle (at protein level).

Evidence on tissue expression from TISSUES for OLFM2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with OLFM2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFM2 Gene

Orthologs for OLFM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFM2 34 35
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia OLFM2 34 35
  • 93.09 (n)
cow
(Bos Taurus)
Mammalia OLFM2 34 35
  • 92.35 (n)
rat
(Rattus norvegicus)
Mammalia Olfm2 34
  • 88.38 (n)
mouse
(Mus musculus)
Mammalia Olfm2 34 16 35
  • 88.23 (n)
oppossum
(Monodelphis domestica)
Mammalia OLFM2 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFM2 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfm2 34
  • 73.98 (n)
zebrafish
(Danio rerio)
Actinopterygii olfm2a 34
  • 73.36 (n)
olfm2b 35
  • 49 (a)
OneToOne
Dr.10562 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.278 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for OLFM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFM2 Gene

ENSEMBL:
Gene Tree for OLFM2 (if available)
TreeFam:
Gene Tree for OLFM2 (if available)

Paralogs for OLFM2 Gene

Paralogs for OLFM2 Gene

(9) SIMAP similar genes for OLFM2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OLFM2: view

Variants for OLFM2 Gene

Sequence variations from dbSNP and Humsavar for OLFM2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036532 A colorectal cancer sample
rs1000022610 -- 9,859,871(+) GCGCA(A/G)TGGCT intron-variant, upstream-variant-2KB
rs1000048748 -- 9,913,836(+) GCGCC(A/G)GCTCG intron-variant, upstream-variant-2KB
rs1000068125 -- 9,853,803(+) ACTCC(-/TGGGGG)TGGGG utr-variant-3-prime
rs1000069185 -- 9,933,427(+) GAGAC(-/G)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFM2 Gene

Variant ID Type Subtype PubMed ID
dgv1710n106 CNV deletion 24896259
dgv1711n106 CNV deletion 24896259
esv2656960 CNV deletion 23128226
esv3643644 CNV loss 21293372
nsv1059984 CNV gain 25217958
nsv1072320 CNV deletion 25765185
nsv520683 CNV loss 19592680
nsv833742 CNV loss 17160897

Variation tolerance for OLFM2 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.91; 93.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLFM2 Gene

Human Gene Mutation Database (HGMD)
OLFM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFM2 Gene

Disorders for OLFM2 Gene

Relevant External Links for OLFM2

Genetic Association Database (GAD)
OLFM2
Human Genome Epidemiology (HuGE) Navigator
OLFM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLFM2

No disorders were found for OLFM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFM2 Gene

Publications for OLFM2 Gene

  1. SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma. (PMID: 17122126) Funayama T. … Shimada N. (Invest. Ophthalmol. Vis. Sci. 2006) 3 22 46 64
  2. Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. (PMID: 15123989) Mukhopadhyay A. … Ray K. (Mol. Vis. 2004) 3 4 22 64
  3. Olfactomedin 2, a novel regulator for transforming growth factor- beta-induced smooth muscle differentiation of human embryonic stem cell-derived mesenchymal cells. (PMID: 25298399) Shi N. … Chen S.Y. (Mol. Biol. Cell 2014) 3 4 64
  4. Olfactomedin 2: expression in the eye and interaction with other olfactomedin domain-containing proteins. (PMID: 21228389) Sultana A. … Tomarev S.I. (Invest. Ophthalmol. Vis. Sci. 2011) 3 4 64
  5. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 46 64

Products for OLFM2 Gene

Sources for OLFM2 Gene

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