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Aliases for OLFM1 Gene

Aliases for OLFM1 Gene

  • Olfactomedin 1 2 3
  • Neuronal Olfactomedin-Related ER Localized Protein 3 4
  • Olfactomedin-1 3 4
  • NOE1 3 4
  • Olfactomedin Related ER Localized Protein 3
  • Neuroblastoma Protein 3
  • Pancortin 1 3
  • Pancortin 2
  • NOELIN1 3
  • NOEL1 4
  • OlfA 3
  • AMY 3

External Ids for OLFM1 Gene

Previous GeneCards Identifiers for OLFM1 Gene

  • GC09P129117
  • GC09P129736
  • GC09P131490
  • GC09P133406
  • GC09P135193
  • GC09P137106
  • GC09P137967
  • GC09P107430

Summaries for OLFM1 Gene

Entrez Gene Summary for OLFM1 Gene

  • This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for OLFM1 Gene

OLFM1 (Olfactomedin 1) is a Protein Coding gene. Diseases associated with OLFM1 include ectopic pregnancy and neuroblastoma. GO annotations related to this gene include beta-amyloid binding. An important paralog of this gene is GLDN.

UniProtKB/Swiss-Prot for OLFM1 Gene

  • Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity).

Gene Wiki entry for OLFM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFM1 Gene

Genomics for OLFM1 Gene

Regulatory Elements for OLFM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OLFM1 Gene

Chromosome:
9
Start:
135,075,243 bp from pter
End:
135,121,184 bp from pter
Size:
45,942 bases
Orientation:
Plus strand

Genomic View for OLFM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLFM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFM1 Gene

Proteins for OLFM1 Gene

  • Protein details for OLFM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99784-NOE1_HUMAN
    Recommended name:
    Noelin
    Protein Accession:
    Q99784
    Secondary Accessions:
    • Q53XZ8
    • Q6IMJ4
    • Q6IMJ5
    • Q8N8R0
    • Q969S7
    • Q99452

    Protein attributes for OLFM1 Gene

    Size:
    485 amino acids
    Molecular mass:
    55343 Da
    Quaternary structure:
    • Homotetramer; disulfide-linked. Dimer of dimers, giving rise to a V-shaped homotretramer. Isoform 1 and isoform 3 nteract with RTN4R. Identified in a complex with RTN4R and LINGO1. Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM1. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity). Interacts with OLFM2 (PubMed:21228389).

    Three dimensional structures from OCA and Proteopedia for OLFM1 Gene

    Alternative splice isoforms for OLFM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFM1 Gene

Proteomics data for OLFM1 Gene at MOPED

Post-translational modifications for OLFM1 Gene

  • Glycosylation at Asn 33, Asn 103, Asn 187, Asn 288, Asn 307, Asn 394, Asn 431, and Asn 473
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for OLFM1 (Olfactomedin-1/Noelin-1)

No data available for DME Specific Peptides for OLFM1 Gene

Domains & Families for OLFM1 Gene

Protein Domains for OLFM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99784

UniProtKB/Swiss-Prot:

NOE1_HUMAN :
  • The protein contains a globular N-terminal tetramerization domain, a long stalk formed by the coiled coil region and a C-terminal olfactomedin-like domain. Interactions between dimers are mediated by the coiled coil region. The dimers interact mostly via the N-terminal tetramerization domain, giving rise to a V-shaped overall architecture of the tetramer.
Domain:
  • The protein contains a globular N-terminal tetramerization domain, a long stalk formed by the coiled coil region and a C-terminal olfactomedin-like domain. Interactions between dimers are mediated by the coiled coil region. The dimers interact mostly via the N-terminal tetramerization domain, giving rise to a V-shaped overall architecture of the tetramer.
  • Contains 1 olfactomedin-like domain.
genes like me logo Genes that share domains with OLFM1: view

No data available for Gene Families for OLFM1 Gene

Function for OLFM1 Gene

Molecular function for OLFM1 Gene

UniProtKB/Swiss-Prot Function:
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity).

Gene Ontology (GO) - Molecular Function for OLFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IEA --
GO:0005515 protein binding IPI 17043677
genes like me logo Genes that share ontologies with OLFM1: view
genes like me logo Genes that share phenotypes with OLFM1: view

Animal Models for OLFM1 Gene

MGI Knock Outs for OLFM1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for OLFM1 Gene

Localization for OLFM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFM1 Gene

Secreted. Cell junction, synapse. Endoplasmic reticulum. Cell projection, axon. Perikaryon.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLFM1 Gene COMPARTMENTS Subcellular localization image for OLFM1 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for OLFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005623 cell ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0030054 cell junction IEA --
GO:0030424 axon ISS --
genes like me logo Genes that share ontologies with OLFM1: view

Pathways & Interactions for OLFM1 Gene

SuperPathways for OLFM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003190 atrioventricular valve formation ISS --
GO:0007399 nervous system development TAS 9039501
GO:0010628 positive regulation of gene expression ISS --
GO:0010629 negative regulation of gene expression ISS --
GO:0010718 positive regulation of epithelial to mesenchymal transition ISS --
genes like me logo Genes that share ontologies with OLFM1: view

No data available for Pathways by source and SIGNOR curated interactions for OLFM1 Gene

Drugs & Compounds for OLFM1 Gene

No Compound Related Data Available

Transcripts for OLFM1 Gene

Unigene Clusters for OLFM1 Gene

Olfactomedin 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLFM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFM1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5:
SP6: - -
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9: -
SP10:
SP11:

Relevant External Links for OLFM1 Gene

GeneLoc Exon Structure for
OLFM1
ECgene alternative splicing isoforms for
OLFM1

Expression for OLFM1 Gene

mRNA expression in normal human tissues for OLFM1 Gene

mRNA differential expression in normal tissues according to GTEx for OLFM1 Gene

This gene is overexpressed in Brain - Cortex (x8.1), Brain - Frontal Cortex (BA9) (x8.0), Brain - Anterior cingulate cortex (BA24) (x6.8), Brain - Hippocampus (x4.8), and Brain - Amygdala (x4.6).

Protein differential expression in normal tissues from HIPED for OLFM1 Gene

This gene is overexpressed in Serum (36.8), Plasma (9.2), and Synovial fluid (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OLFM1 Gene



SOURCE GeneReport for Unigene cluster for OLFM1 Gene Hs.522484

genes like me logo Genes that share expression patterns with OLFM1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OLFM1 Gene

Orthologs for OLFM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFM1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia OLFM1 35
  • 92.18 (n)
  • 97.68 (a)
OLFM1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfm1 35
  • 91.34 (n)
  • 98.35 (a)
Olfm1 16
Olfm1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OLFM1 35
  • 99.07 (n)
  • 99.3 (a)
OLFM1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olfm1 35
  • 92.23 (n)
  • 98.35 (a)
cow
(Bos Taurus)
Mammalia OLFM1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLFM1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLFM1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLFM1 35
  • 86.46 (n)
  • 96.08 (a)
OLFM1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFM1 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfm1 35
  • 83.78 (n)
  • 93.2 (a)
Str.12087 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398287 35
zebrafish
(Danio rerio)
Actinopterygii olfm1a 36
  • 76 (a)
OneToMany
olfm1b 36
  • 75 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for OLFM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFM1 Gene

ENSEMBL:
Gene Tree for OLFM1 (if available)
TreeFam:
Gene Tree for OLFM1 (if available)

Paralogs for OLFM1 Gene

Paralogs for OLFM1 Gene

Pseudogenes.org Pseudogenes for OLFM1 Gene

genes like me logo Genes that share paralogs with OLFM1: view

Variants for OLFM1 Gene

Sequence variations from dbSNP and Humsavar for OLFM1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3781 -- 135,097,943(-) GAGGA(G/T)CCTGG intron-variant, utr-variant-3-prime
rs6535 -- 135,119,656(+) TACTT(C/T)AACAA reference, synonymous-codon
rs11834 -- 135,120,566(+) GTGGC(A/G)TCCAG utr-variant-3-prime
rs14164 -- 135,120,735(+) CAGAG(G/T)GTGTA utr-variant-3-prime
rs15841 -- 135,097,941(+) AACCA(A/G)GATCC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OLFM1 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv894207 CNV Loss 21882294
nsv831754 CNV Loss 17160897
nsv894209 CNV Loss 21882294
nsv509330 CNV Insertion 20534489
esv2025540 CNV Deletion 18987734
nsv6756 CNV Insertion 18451855
nsv513001 CNV Insertion 21212237
esv1343927 CNV Insertion 17803354
nsv825156 CNV Gain 20364138
nsv825157 CNV Gain 20364138
dgv8356n71 CNV Loss 21882294
nsv894211 CNV Loss 21882294
esv29590 CNV Loss 19812545

Variation tolerance for OLFM1 Gene

Residual Variation Intolerance Score: 8.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLFM1 Gene

HapMap Linkage Disequilibrium report
OLFM1
Human Gene Mutation Database (HGMD)
OLFM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFM1 Gene

Disorders for OLFM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OLFM1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ectopic pregnancy
  • eccyesis
neuroblastoma
  • neuroblastoma 1
- elite association
Search OLFM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OLFM1

Genetic Association Database (GAD)
OLFM1
Human Genome Epidemiology (HuGE) Navigator
OLFM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLFM1
genes like me logo Genes that share disorders with OLFM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OLFM1 Gene

Publications for OLFM1 Gene

  1. Gene expression profiling in lung tissues from rats exposed to formaldehyde. (PMID: 17285311) Sul D. … Jung W.W. (Arch. Toxicol. 2007) 23 67
  2. Differentially expressed genes implicated in unexplained recurrent spontaneous abortion. (PMID: 17681868) Lee J. … Cho C. (Int. J. Biochem. Cell Biol. 2007) 23 67
  3. Mutated mouse and human myocilins have similar properties and do not block general secretory pathway. (PMID: 16384964) Malyukova I. … Tomarev S.I. (Invest. Ophthalmol. Vis. Sci. 2006) 23 67
  4. Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors. (PMID: 16412616) Sakuragi M. … Sasai Y. (Mech. Dev. 2006) 23 67
  5. Noelins modulate the timing of neuronal differentiation during development. (PMID: 16289448) Moreno T.A. … Bronner-Fraser M. (Dev. Biol. 2005) 23 67

Products for OLFM1 Gene

Sources for OLFM1 Gene

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