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Aliases & Descriptions for OLFM1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases AMY 1 , 2 , 5 NOE1 1 , 2 , 3 NOEL1 3 NOELIN 1 NOELIN1 2 OTTHUMP00000022526 2 OTTHUMP00000022527 2 OlfA 1 , 2 Olfactomedin-1 3 noelin 2
Descriptions Neuronal olfactomedin-related ER localized protein 3 neuroblastoma protein 2 olfactomedin 1 2 olfactomedin related ER localized protein 2 pancortin 1 2
Search outside databases for aliases for OLFM1 genePrevious GC identifers: GC09P129117 GC09P129736 GC09P131490 GC09P133406 GC09P135193
Summaries for OLFM1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for OLFM1 : This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-relatedER localized protein. While the exact function of the encoded protein is not known, its abundantexpression in brain suggests that it may have an essential role in nerve tissue. Severalalternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq] UniProtKB/Swiss-Prot: NOE1_HUMAN, Q99784 Function : Seems to play an important role in regulating the production of neural crest cells by theneural tube (By similarity)
Gene Wiki entry for OLFM1
Genomic Location for OLFM1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the OLFM1 gene Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3 OLFM1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09P137106:
(about GC identifiers )
Start:
137,106,910 bp from pter
End:
137,152,851 bp from pter
Size:
45,942 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000009.10 NT_019501.13 Proteins for OLFM1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: NOE1_HUMAN, Q99784 (See
protein sequence )Recommended Name: Noelin precursor Size : 485 amino acids; 55343 Da
Subcellular location : Endoplasmic reticulum lumen (Potential)
Secondary accessions : Q53XZ8 Q6IMJ4 Q969S7 Q99452Alternative splicing : 4 isoforms : Q99784-1 Q99784-2 Q99784-3 Q99784-4 (Experimental confirmation may be lacking for some isoforms)
REFSEQ proteins (2 alternative transcripts):
NP_006325.1 NP_055094.1 ENSEMBL proteins: ENSP00000252854 ENSP00000340318 ENSP00000277415 ENSP00000360864 ENSP00000360866 ENSP00000360861 ENSP00000360858 ENSP00000376717 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for OLFM1: Assays for OLFM1:
Protein
Domains/ Families for OLFM1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q99784 ProtoNet protein and cluster: Q99784
1 Blocks protein family : IPB003112 Olfactomedin-like UniProtKB/Swiss-Prot: NOE1_HUMAN, Q99784 Similarity : Contains 1 olfactomedin-like domain
Gene Function for OLFM1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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RNAi Products ,
Clones , and
Q-PCR Products
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Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_006334 Applied Biosystems Silencer ® siRNAs for OLFM1 Sigma-Aldrich siRNA for OLFM1 Sigma-Aldrich shRNA for OLFM1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_006334                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_006334                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_006334  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014279 UniProtKB/Swiss-Prot: NOE1_HUMAN, Q99784 Function : Seems to play an important role in regulating the production of neural crest cells by theneural tube (By similarity)
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Olfm1) :1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for OLFM1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/13 Interacting proteins for OLFM1 (ENSP00000360858 3 Q99784 1 ) via UniProtKB, MINT, and/or STRING (see all 13
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007275 multicellular organismal development
IEA -- GO:0007399 nervous system development
TAS 9039501
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Drugs & Compounds for OLFM1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Browse Tocris compounds for OLFM1
Transcripts for OLFM1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_006334 Sigma-Aldrich siRNA for OLFM1 Sigma-Aldrich shRNA for OLFM1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_006334 NM_014279
REFSEQ mRNAs for OLFM1 gene (2 alternative transcripts): NM_006334.3 NM_014279.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006334 NM_014279
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_006334                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_006334                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_006334  
Additional cDNA sequence: AF035301.1 AK090782.1 AK090818.1 AK096304.1 AK289719.1 AK289921.1 AK290478.1 BC000189.1 BC008763.2 BC011741.2 BC015437.2 BT007146.1 CR611553.1 CR621361.1 CR621412.1 D82343.1 U79299.1
14 DOTS entries : DT.449449 DT.100755444 DT.100027832 DT.92430258 DT.95293576 DT.99930253 DT.99982681 DT.40109076 DT.95293570 DT.102826070 DT.121165746 DT.95129327 DT.95293568 DT.95293574
24/375 AceView cDNA sequences (see all 375
):F06276 F08900 BM709177 F05067 F02071 AW005795 AW204308 F03386 F02767 F10941 F05512 CR611553 AA364901 AI571275 AF035301 AA894836 F02082 F09914 F09434 F02170 AI991965 BU187146 AA704033 BQ431812
highest scoring ESTs for OLFM1 :AF035301 AW005932 R59468 AA331914 AA515969 AA558516 AA730438 AA814486 AI082296 AI198226
Unigene Cluster for OLFM1: Olfactomedin 1 Hs.522484 [show with all ESTs ] Unigene Representative Sequence: NM_014279 GeneLoc Exon Structure 5/11 Alternative Splicing Database (ASD) splice patterns (SP) for OLFM1 (see all 11
) ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 SP1 :                     -   -   -           -   -           -       SP2 :             -   -   -   -   -   -   -           -   -           -       SP3 :                   -   -   -   -           -   -                 SP4 :                         -           -   -                 SP5 :                                                    
About this scheme ECgene alternative splicing isoforms for OLFM1 8 Ensembl transcripts including schematic representations : ENST00000252854
ENST00000339720
ENST00000277415
ENST00000371799
ENST00000371801
ENST00000371796
ENST00000371793
ENST00000392991
Expression for OLFM1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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OLFM1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for OLFM1 1 / 2 / 3
11 probe-sets matching OLFM1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TAACCTTAAGSOURCE GeneReport for Unigene cluster: Hs.522484 Expression variation in blood from EXPOLDB for OLFM1
Orthologs for OLFM1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for OLFM1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for OLFM1 ENSEMBL Gene Tree for OLFM1 Paralogs for OLFM1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for OLFM1 gene MYOC 2 OLFM3 2 OLFM2 2
SNPs/Variants for OLFM1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for OLFM1 (up to first 250kb)
Disorders & Mutations for OLFM1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 605366
Medical News for OLFM1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for OLFM1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/18 PubMed articles for OLFM1 gene (see all 18
): Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles. (PubMed id 9039501) 2, 3, 4 Yokoyama M.... Matsubara K. (1996) Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952) 3, 4 Liu T.... Smith R.D. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Large-scale concatenation cDNA sequencing. (PubMed id 9110174) 3, 4 Yu W....Gibbs R.A. (1997) Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. (PubMed id 15123989) 1, 4 Mukhopadhyay A.... Ray K. (2004) Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677) 3 Camargo L.M....Brandon N.J. (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 3 Kimura K.... Sugano S. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474) 3 Andersson B....Gibbs R.A. (1996)
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Genome Databases showing OLFM1
(According to
Entrez Gene ,
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
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Specialized Databases showing OLFM1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for OLFM1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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