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OLFM1 Gene

protein-coding   GIFtS: 56

GC09P137106
olfactomedin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AMY 1, 2, 5
NOE1 1, 2, 3
NOEL1 3
NOELIN 1
NOELIN1 2
OTTHUMP00000022526 2
OTTHUMP00000022527 2
OlfA 1, 2
Olfactomedin-1 3
noelin 2
Descriptions
Neuronal olfactomedin-related ER localized protein 3
neuroblastoma protein 2
olfactomedin 1 2
olfactomedin related ER localized protein 2
pancortin 1 2
External Ids
HGNC: 171871
Entrez Gene: 104392
UniProtKB: Q997843
Ensembl: ENSG000001305587
Search outside databases for aliases for OLFM1 gene

Previous GC identifers: GC09P129117 GC09P129736 GC09P131490 GC09P133406 GC09P135193

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OLFM1:
This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related
ER localized protein. While the exact function of the encoded protein is not known, its abundant
expression in brain suggests that it may have an essential role in nerve tissue. Several
alternatively spliced transcripts encoding different isoforms have been found for this gene.
[provided by RefSeq]

UniProtKB/Swiss-Prot: NOE1_HUMAN, Q99784
Function: Seems to play an important role in regulating the production of neural crest cells by the
neural tube (By similarity)

Gene Wiki entry for OLFM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OLFM1 gene  

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

OLFM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P137106:     (about GC identifiers)

Start:
137,106,910 bp from pter
End:
137,152,851 bp from pter
Size:
45,942 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000009.10  NT_019501.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NOE1_HUMAN, Q99784 (See protein sequence)
Recommended Name: Noelin precursor  
Size: 485 amino acids; 55343 Da
Subcellular location: Endoplasmic reticulum lumen (Potential)
Secondary accessions: Q53XZ8 Q6IMJ4 Q969S7 Q99452
Alternative splicing: 4 isoforms:  Q99784-1   Q99784-2   Q99784-3   Q99784-4   (Experimental confirmation may be lacking for some isoforms)

REFSEQ proteins (2 alternative transcripts): 
NP_006325.1  NP_055094.1  


ENSEMBL proteins: 
ENSP00000252854 ENSP00000340318 ENSP00000277415 ENSP00000360864 ENSP00000360866 ENSP00000360861 
ENSP00000360858 ENSP00000376717 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Noelin)
Human Recombinant Proteins from Abnova (OLFM1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005783 endoplasmic reticulum IEA--
GO:0005788 endoplasmic reticulum lumen IEA--
GO:0016020 membrane IEA--
About this table

Antibodies for OLFM1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for OLFM1
R&D Systems Antibodies for OLFM1 (Noelin-1)
Antibodies from Abcam (Noelin), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Novus Biologicals Antibodies for OLFM1

Assays for OLFM1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro domains/families:
 IPR003112 Olfac-like
 IPR000886 ER_targeting_sequence
 IPR003924 GPCR_2_latrophilin


   GeneDecks  OLFM1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q99784

ProtoNet protein and cluster: Q99784

1 Blocks protein family: IPB003112 Olfactomedin-like

UniProtKB/Swiss-Prot: NOE1_HUMAN, Q99784
Similarity: Contains 1 olfactomedin-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OLFM1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OLFM1)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_006334

              Applied Biosystems Silencer® siRNAs for OLFM1

              Sigma-Aldrich siRNA for OLFM1  
                     Sigma-Aldrich shRNA for OLFM1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for OLFM1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_006334
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_006334
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_006334 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_014279

UniProtKB/Swiss-Prot: NOE1_HUMAN, Q99784
Function: Seems to play an important role in regulating the production of neural crest cells by the
neural tube (By similarity)

4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Olfm1):

homeostasis/metabolismnervous systemno phenotypic analysisreproductive system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IPI17043677
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



5/13 Interacting proteins for OLFM1 (ENSP000003608583 Q997841) via UniProtKB, MINT, and/or STRING (see all 13 )
InteractantInteraction Details
GeneCardExternal ID(s)
DISC1Q9NRI51EBI-1105073, EBI-529989
CALCRENSP000003533853STRING (score=.884)
ISL1ENSP000002306583STRING (score=.86)
GJA9ENSP000003540203STRING (score=.75)
IAPPENSP000002406523STRING (score=.746)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007275 multicellular organismal development IEA--
GO:0007399 nervous system development TAS9039501
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OLFM1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OLFM1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OLFM1)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_006334

              Sigma-Aldrich siRNA for OLFM1  
                     Sigma-Aldrich shRNA for OLFM1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_006334  NM_014279  

REFSEQ mRNAs for OLFM1 gene (2 alternative transcripts): 

NM_006334.3   NM_014279.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_006334  NM_014279  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_006334
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_006334
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_006334 

Additional cDNA sequence: 

AF035301.1 AK090782.1 AK090818.1 AK096304.1 AK289719.1 AK289921.1 AK290478.1 BC000189.1 
BC008763.2 BC011741.2 BC015437.2 BT007146.1 CR611553.1 CR621361.1 CR621412.1 D82343.1 
U79299.1 

14 DOTS entries:

DT.449449  DT.100755444  DT.100027832  DT.92430258  DT.95293576  DT.99930253  DT.99982681  DT.40109076 
DT.95293570  DT.102826070  DT.121165746  DT.95129327  DT.95293568  DT.95293574 

24/375 AceView cDNA sequences (see all 375 ):

F06276 F08900 BM709177 F05067 F02071 AW005795 AW204308 F03386 
F02767 F10941 F05512 CR611553 AA364901 AI571275 AF035301 AA894836 
F02082 F09914 F09434 F02170 AI991965 BU187146 AA704033 BQ431812 

highest scoring ESTs for OLFM1:

AF035301 AW005932 R59468 AA331914 AA515969 AA558516 AA730438 AA814486 AI082296 AI198226 

Unigene Cluster for OLFM1:

Olfactomedin 1
Hs.522484  [show with all ESTs]
Unigene Representative Sequence: NM_014279


GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for OLFM1 (see all 11 )

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13
SP1:                                                              -     -     -                             -     -                             -               
SP2:                                      -     -     -     -     -     -     -                             -     -                             -               
SP3:                                                        -     -     -     -                             -     -                                             
SP4:                                                                          -                             -     -                                             
SP5:                                                                                                                                                            

About this scheme

ECgene alternative splicing isoforms for OLFM1

8 Ensembl transcripts including schematic representations:
ENST00000252854  ENST00000339720  ENST00000277415  ENST00000371799  ENST00000371801  ENST00000371796  
ENST00000371793  ENST00000392991  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OLFM1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OLFM1

1 / 2 / 3

11 probe-sets matching OLFM1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
87939_s_at2, 3 U95-E 1 1.00 1.00 0.99 1.27 AW005932 1.00 1.00 1.00 1
78168_s_at2, 3 U95-E 1 1.00 1.00 0.89 0.70 AI952712 0.80 1.00 0.91 1
38855_s_at2, 3 U95-A 1 1.00 1.00 0.97 0.91 D82343 0.80 1.00 0.91 1
36134_at2, 3 U95-A 1 1.00 1.00 0.97 0.97 AF035301 1.00 1.00 1.00 1
78170_s_at2, 3 U95-E 1 1.00 1.00 0.98 1.19 R59468 1.00 1.00 1.00 1

213131_at2, 3 U133-A 1 1.00 1.00 -- -- R38389 0.60 1.00 0.82 1

210924_at2, 3 U133-A 1 1.00 1.00 -- -- BC000189 0.60 1.00 0.82 1

205591_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006334 0.60 1.00 0.82 1

213131_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

210924_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

205591_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  OLFM1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TAACCTTAAG

SOURCE GeneReport for Unigene cluster: Hs.522484

Expression variation in blood from EXPOLDB for OLFM1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for OLFM1 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
OLFM11   -- olfactomedin 1 92.49(n)
97.36(a)
480685  XM_537805.2  XP_537805.2 
cow
(Bos taurus)
OLFM11   -- olfactomedin 1 92.27(n)
97(a)
507002  XM_583541.3  XP_583541.3 
rat
(Rattus norvegicus)
Olfm11   -- olfactomedin 1 91.69(n)
98.4(a)
93667  NM_053573.1  NP_446025.1 
mouse
(Mus musculus)
Olfm11, 5 25
olfactomedin 11, 5 90.88(n)1
97.81(a)1
561771  NM_001038613.11  NP_001033702.11 
 AF0287405  AK0030315  (see all 22)
chicken
(Gallus gallus)
OLFM11   -- olfactomedin 1 86.65(n)
95.88(a)
395535  NM_204767.1  NP_990098.1 
About this table        Species with no ortholog for OLFM1

ENSEMBL Gene Tree for OLFM1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for OLFM1 gene
MYOC2  OLFM32  OLFM22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/416 NCBI SNPs in OLFM1 are shown (see all 416 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 201)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs167811,2
A,C,F,H137152707(+) GGCTCG/ACCTGG 1 -- ut31 ese35Minor allele frequency- A:0.08EU EA WA 428
rs70479011,2
A,C,F,H137153236(+) CTAGGG/CCTGCA 1 -- ng314Minor allele frequency- C:0.04EU EA WA 370
rs111036841,2
A,C,F,H137151891(+) AAAGGG/AACTCC 1 -- ut31 ese38Minor allele frequency- A:0.05EU EA WA 838
rs70354731,2
A,C,F,H137153186(+) TCAGCA/GCTGGC 1 -- ng314Minor allele frequency- G:0.04EU EA WA 400
rs93082811,2
A,C,F,H137105231(+) CTCAAC/TGATCC 2 -- ng514Minor allele frequency- T:0.42EU EA WA 418
rs118341,2
A,C,F,H137152233(+) GTGGCG/ATCCAG 1 -- ut31 ese35Minor allele frequency- A:0.06MN EU EA WA 562
rs22982491,2
C,F,H137152468(-) AGAACG/ATTGCA 1 -- ut31 ese38Minor allele frequency- A:0.20EA NA EU WA 2044
--
rs108583341,2
C,F,H137129606(+) ACAACC/GAGGAT 2 -- int1 ut318Minor allele frequency- G:0.35EU EA WA 836
rs70390981,2
A,C137153140(+) CTCCAC/TAGACA 1 -- ng310--------
rs8998431,2
A,C137106752(+) CCCCCC/TCCCCA 2 -- ng51 tfbs3 trp30--------
About this table

HapMap Linkage Disequilibrium images for OLFM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605366

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/18 PubMed articles for OLFM1 gene (see all 18 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10439 HGNC: 17187 AceView: OLFM1 Ensembl:ENSG00000130558 euGenes: HUgn10439
ECgene: OLFM1 H-InvDB: OLFM1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OLFM1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for OLFM1 Antibodies for OLFM1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OLFM1 Browse small molecules at Sigma-Aldrich
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 Antibodies for OLFM1

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