Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OLAH Gene

protein-coding   GIFtS: 51
GCID: GC10P015074

Oleoyl-ACP Hydrolase

(Previous name: thioesterase domain containing 1)
(Previous symbol: THEDC1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Oleoyl-ACP Hydrolase1 2 3     Thioesterase II2 3
THEDC11 2 3     AURA12 3
Thioesterase Domain Containing 11 2     SAST2
Augmented In Rheumatoid Arthritis 12 3     S-Acyl Fatty Acid Synthase Thioesterase, Medium Chain2
Thioesterase Domain-Containing Protein 12 3     EC 3.1.2.143

External Ids:    HGNC: 256251   Entrez Gene: 553012   Ensembl: ENSG000001524637   UniProtKB: Q9NV233   

Export aliases for OLAH gene to outside databases

Previous GC identifers: GC10P015126 GC10P014996


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OLAH Gene: 
OLAH (oleoyl-ACP hydrolase) is a protein-coding gene. Diseases associated with OLAH include arthritis, and rheumatoid arthritis, and among its related super-pathways are Saturated fatty acid biosynthesis and Metabolism. GO annotations related to this gene include oleoyl-[acyl-carrier-protein] hydrolase activity and palmitoyl-[acyl-carrier-protein] hydrolase activity.

UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23
Function: In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by
hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain
length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in
the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length
fatty acids (C8 to C2) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OLAH gene promoter:
         Bach1   SRF   POU2F1   SRF (504 AA)   POU2F1a   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOLAH promoter sequence
   Search SABiosciences Chromatin IP Primers for OLAH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLAH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

OLAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLAH gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P015074:  view genomic region     (about GC identifiers)

Start:
15,074,226 bp from pter      End:
15,115,851 bp from pter
Size:
41,626 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23 (See protein sequence)
Recommended Name: S-acyl fatty acid synthase thioesterase, medium chain  
Size: 265 amino acids; 29931 Da
Secondary accessions: Q5VUB6 Q9NUW1
Alternative splicing: 2 isoforms:  Q9NV23-1   Q9NV23-2   

Explore the universe of human proteins at neXtProt for OLAH: NX_Q9NV23

Explore proteomics data for OLAH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NV23

  • OLAH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OLAH Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001034791.1  NP_060794.1  

    ENSEMBL proteins: 
     ENSP00000399290   ENSP00000399449   ENSP00000399663   ENSP00000367473   ENSP00000367470  
     ENSP00000367462  

    Human Recombinant Protein Products for OLAH: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for OLAH
    OriGene Protein Over-expression Lysate for OLAH
    OriGene MassSpec for OLAH 
    OriGene Custom Protein Services for OLAH
    GenScript Custom Purified and Recombinant Proteins Services for OLAH
    Novus Biologicals OLAH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OLAH 


    OLAH Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for OLAH
    GenScript Custom Superior Antibodies Services for OLAH
    Novus Biologicals OLAH Antibodies
    Abcam antibodies for OLAH
    Cloud-Clone Corp. Antibodies for OLAH 
    Search ThermoFisher Antibodies for OLAH
    LSBio Antibodies in human, mouse, rat for OLAH 

    Assay Products for OLAH: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OLAH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OLAH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OLAH 
    Cloud-Clone Corp. CLIAs for OLAH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR012223 TEII
     IPR001031 Thioesterase

    Graphical View of Domain Structure for InterPro Entry Q9NV23

    ProtoNet protein and cluster: Q9NV23

    1 Blocks protein domain: IPB001031 Thioesterase

    UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23
    Similarity: Belongs to the thioesterase family


    OLAH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAST_HUMAN, Q9NV23
    Function: In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by
    hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain
    length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in
    the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length
    fatty acids (C8 to C2) (By similarity)
    Catalytic activity: Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate

         Enzyme Number (IUBMB): EC 3.1.2.141

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004320oleoyl-[acyl-carrier-protein] hydrolase activity IEA--
    GO:0016295myristoyl-[acyl-carrier-protein] hydrolase activity IEA--
    GO:0016296palmitoyl-[acyl-carrier-protein] hydrolase activity IEA--
    GO:0016788hydrolase activity, acting on ester bonds ----
         
    OLAH for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OLAH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OLAH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OLAH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OLAH 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OLAH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate OLAH
    SwitchGear 3'UTR luciferase reporter plasmidOLAH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OLAH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OLAH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OLAH
    Sirion Biotech Customized adenovirus for overexpression of OLAH

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for OLAH (see all 12)
    OriGene ORF clones in mouse, rat for OLAH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): OLAH (NM_001039702)
    Sino Biological Human cDNA Clone for OLAH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OLAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLAH
    Sirion Biotech Customized lentivirus for stable overexpression of OLAH 
                         Customized lentivirus expression plasmids for stable overexpression of OLAH 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OLAH
    Search LifeMap BioReagents cell lines for OLAH
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLAH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OLAH About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Saturated fatty acid biosynthesis
    Fatty acid biosynthesis0.50
    2Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2         Kegg Pathways  (Kegg details for OLAH):
        Fatty acid biosynthesis
    Metabolic pathways


    OLAH for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OLAH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for OLAH (ENSP000003674624) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FASNENSP000003045924STRING: ENSP00000304592
    OXSMENSP000002807014STRING: ENSP00000280701
    CAP1ENSP000003618784STRING: ENSP00000361878
    DNAJC1ENSP000003661794STRING: ENSP00000366179
    ENSG00000226467ENSP000004058644STRING: ENSP00000405864
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0009058biosynthetic process ----

    OLAH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OLAH (SAST)

    7 HMDB Compounds for OLAH    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dodecanoic acid1-Undecanecarboxylate (see all 28)143-07-7--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
    Oleic acid(9Z)-9-Octadecenoate (see all 67)112-80-1--
    Palmitic acidHexaectylic acid (see all 45)57-10-3--
    Palmitoleic acid(Z)-9-Hexadecenoate (see all 23)373-49-9--
    Stearic acid1-Heptadecanecarboxylate (see all 12)57-11-4--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about OLAH / SAST

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OLAH gene (2 alternative transcripts): 
    NM_001039702.2  NM_018324.2  

    Unigene Cluster for OLAH:

    Oleoyl-ACP hydrolase
    Hs.24309  [show with all ESTs]
    Unigene Representative Sequence: NM_018324
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428897 ENST00000413672 ENST00000429028 ENST00000378228(uc001inu.2)
    ENST00000378225 ENST00000378217(uc001int.2) ENST00000493912 ENST00000485251


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OLAH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate OLAH
    SwitchGear 3'UTR luciferase reporter plasmidOLAH 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OLAH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OLAH
    Clone
    Products:
         
    OriGene clones in human, mouse for OLAH (see all 12)
    OriGene ORF clones in mouse, rat for OLAH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): OLAH (NM_001039702)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OLAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLAH
    Sirion Biotech Customized lentivirus for stable overexpression of OLAH 
                         Customized lentivirus expression plasmids for stable overexpression of OLAH 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OLAH
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OLAH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLAH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLAH

    Additional mRNA sequence: 

    AK001844.1 AK001968.1 BC050372.1 

    8 DOTS entries:

    DT.91724773  DT.310766  DT.100751709  DT.75135089  DT.100751708  DT.121258176  DT.91724767  DT.95370676 

    24/47 AceView cDNA sequences (see all 47):

    BC050372 BX118351 BQ013235 BM554164 AA470066 AI151217 AK001844 BE782959 
    AI125816 AA431387 AI247444 BF125008 BE781387 AI208288 BG475148 AU137095 
    NM_018324 AI125696 AA758593 AA694484 AU135292 AI183402 AA432379 AK001968 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for OLAH    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                    -                 -                 -                     
    SP2:                    -                                                         
    SP3:                                      -                                       
    SP4:                                                                              


    ECgene alternative splicing isoforms for OLAH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OLAH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTAGTAAAT
    OLAH Expression
    About this image


    See OLAH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OLAH

    SOURCE GeneReport for Unigene cluster: Hs.24309

    UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23
    Tissue specificity: Isoform 2 is up-regulated in bone marrow-derived mononuclear cells of rheumatoid arthritis
    patients

        SABiosciences Custom PCR Arrays for OLAH
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OLAH
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OLAH
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLAH
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLAH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLAH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OLAH gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olah1 , 5 oleoyl-ACP hydrolase1, 5 72.7(n)1
    59.25(a)1
      2 (1.88 cM)5
    990351  NM_145921.11  NP_666033.11 
     33419825 
    chicken
    (Gallus gallus)
    Aves OLAH1 oleoyl-ACP hydrolase 59.67(n)
    44.03(a)
      420532  XM_418634.2  XP_418634.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1369261 zgc:136926 51.47(n)
    41.2(a)
      568096  NM_001039932.1  NP_001035021.1 


    ENSEMBL Gene Tree for OLAH (if available)
    TreeFam Gene Tree for OLAH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/747 SNPs in OLAH are shown (see all 747)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727743471,2
    C,F--15083928(+) AGTTAC/TGTCTT 2 -- us2k15Minor allele frequency- T:0.14WA NA EA 362
    rs1905012771,2
    --15084010(+) TGCTAA/GTGATT 2 -- us2k10--------
    rs1457985981,2
    C--15084076(+) GTAATA/TGAGTT 2 -- us2k10--------
    rs37637821,2
    C--15084265(+) CCTGCC/TTCAGC 2 -- us2k13Minor allele frequency- T:0.17NA 6
    rs1819827041,2
    --15084312(+) CGCCCA/CGCTAA 2 -- us2k10--------
    rs37637831,2
    C,F,A--15084471(+) ATACAG/CGCATG 2 -- us2k1 tfbs38Minor allele frequency- C:0.31NA CSA WA EA 368
    rs37637841,2
    C,F,H--15084490(+) TGTCAC/TGGAGA 2 -- us2k1 tfbs319Minor allele frequency- N:0.01NS EA NA WA 1418
    rs1436866771,2
    --15084558(+) CTCTTA/CTAGTC 2 -- us2k10--------
    rs37637851,2
    C,F,H--15084568(+) CATTTT/CAGAAT 2 -- us2k110Minor allele frequency- C:0.20NS EA NA WA 756
    rs3760333801,2
    C--15084580(+) GTACA-/TTAAG 
            
    TAAGT
    2 -- us2k10--------

    HapMap Linkage Disequilibrium report for OLAH (15074226 - 15115851 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OLAH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831793CNV Loss17160897
    nsv831794CNV Loss17160897
    dgv618n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OLAH
    DNA2.0 Custom Variant and Variant Library Synthesis for OLAH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for OLAH:    About MalaCards
    arthritis    rheumatoid arthritis    tuberculosis    alzheimer's disease


    OLAH for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): OLAH
    Human Genome Epidemiology (HuGE) Navigator: OLAH (7 documents)

    Export disorders for OLAH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OLAH gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OLAH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. (PubMed id 17082220)1, 2 Nakamura N.... Ochi T. (2006)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55301 HGNC: 25625 AceView: THEDC1 Ensembl:ENSG00000152463 euGenes: HUgn55301
    ECgene: OLAH Kegg: 55301 H-InvDB: OLAH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OLAH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OLAH gene:
    Search GeneIP for patents involving OLAH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OLAH  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for OLAH  
     OriGene MassSpec something-or-other for OLAH   OriGene clones in human, mouse for OLAH  
     OriGene qSTAR qPCR primer pairs in human, mouse for OLAH   OriGene Purified Protein for OLAH  
     OriGene ORF clones in mouse, rat for OLAH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OLAH   OriGene Custom Protein Services for OLAH  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OLAH
     QIAGEN SeqTarget long-range PCR primers for resequencing OLAH
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLAH
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OLAH
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLAH
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLAH
     GenScript Custom Purified and Recombinant Proteins Services for OLAH GenScript cDNA clones with any tag delivered in your preferred vector for OLAH
     GenScript Custom Assay Services for OLAH GenScript Custom Superior Antibodies Services for OLAH
     GenScript Custom overexpressing Cell Line Services for OLAH CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in OLAH promoter
     Search Chromatin IP Primers for OLAH
     RT2 qPCR Primer Assay in human, mouse, rat OLAH
     Search GNC Networks for OLAH
     SABiosciences Custom PCR Arrays for OLAH
     Search Tocris compounds for OLAH (SAST)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for OLAH
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     OLAH antibodies
     OLAH lysates
     Antibodies for OLAH
     See all of Abcam's Antibodies, Kits and Proteins for OLAH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for OLAH
     Antibodies for OLAH
     ELISAs for OLAH
     CLIAs for OLAH
     Search LifeMap BioReagents cell lines for OLAH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLAH
     SwitchGear 3'UTR luciferase reporter plasmids for OLAH
     SwitchGear Promoter luciferase reporter plasmids for OLAH
     Search ThermoFisher Antibodies for OLAH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLAH
     inGenious Targeting Laboratory - Custom generated mouse model solutions for OLAH
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OLAH
    Customized:
     lentivirus for stable overexpression of OLAH
     lentivirus expression plasmids for stable overexpression of OLAH
     adenovirus for overexpression of OLAH
     LSBio Antibodies in human, mouse, rat for OLAH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OLAH gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4