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Aliases for OLAH Gene

Aliases for OLAH Gene

  • Oleoyl-ACP Hydrolase 2 3 4
  • Thioesterase Domain-Containing Protein 1 3 4
  • Augmented In Rheumatoid Arthritis 1 3 4
  • Thioesterase Domain Containing 1 2 3
  • Thioesterase II 3 4
  • THEDC1 3 4
  • AURA1 3 4
  • S-Acyl Fatty Acid Synthase Thioesterase, Medium Chain 3
  • EC 3.1.2.14 4
  • SAST 3

External Ids for OLAH Gene

Previous HGNC Symbols for OLAH Gene

  • THEDC1

Previous GeneCards Identifiers for OLAH Gene

  • GC10P015126
  • GC10P014996

Summaries for OLAH Gene

GeneCards Summary for OLAH Gene

OLAH (Oleoyl-ACP Hydrolase) is a Protein Coding gene. Diseases associated with OLAH include arthritis and rheumatoid arthritis. Among its related pathways are Metabolism and Fatty acid metabolism. GO annotations related to this gene include oleoyl-[acyl-carrier-protein] hydrolase activity and palmitoyl-[acyl-carrier-protein] hydrolase activity.

UniProtKB/Swiss-Prot for OLAH Gene

  • In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLAH Gene

Genomics for OLAH Gene

Regulatory Elements for OLAH Gene

Genomic Location for OLAH Gene

Start:
15,032,227 bp from pter
End:
15,073,852 bp from pter
Size:
41,626 bases
Orientation:
Plus strand

Genomic View for OLAH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLAH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLAH Gene

Proteins for OLAH Gene

  • Protein details for OLAH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV23-SAST_HUMAN
    Recommended name:
    S-acyl fatty acid synthase thioesterase, medium chain
    Protein Accession:
    Q9NV23
    Secondary Accessions:
    • Q5VUB6
    • Q9NUW1

    Protein attributes for OLAH Gene

    Size:
    265 amino acids
    Molecular mass:
    29931 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OLAH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLAH Gene

Proteomics data for OLAH Gene at MOPED

Post-translational modifications for OLAH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OLAH Gene

No data available for DME Specific Peptides for OLAH Gene

Domains for OLAH Gene

Protein Domains for OLAH Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OLAH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NV23

UniProtKB/Swiss-Prot:

SAST_HUMAN :
  • Q9NV23
Family:
  • Belongs to the thioesterase family.
genes like me logo Genes that share domains with OLAH: view

No data available for Gene Families for OLAH Gene

Function for OLAH Gene

Molecular function for OLAH Gene

UniProtKB/Swiss-Prot CatalyticActivity: Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate
UniProtKB/Swiss-Prot Function: In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity).

Enzyme Numbers (IUBMB) for OLAH Gene

Gene Ontology (GO) - Molecular Function for OLAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity IEA --
GO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity IEA --
GO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds --
genes like me logo Genes that share ontologies with OLAH: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OLAH Gene

Localization for OLAH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLAH Gene COMPARTMENTS Subcellular localization image for OLAH gene
Compartment Confidence
chloroplast 1
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OLAH Gene

Pathways for OLAH Gene

genes like me logo Genes that share pathways with OLAH: view

Pathways by source for OLAH Gene

Interacting Proteins for OLAH Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367462%0d%0a9606.ENSP00000304592%0d%0a9606.ENSP00000280701%0d%0a
Selected Interacting proteins: ENSP00000367462 for OLAH Gene via STRING

Gene Ontology (GO) - Biological Process for OLAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0009058 biosynthetic process --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with OLAH: view

Compounds for OLAH Gene

(7) HMDB Compounds for OLAH Gene

Compound Synonyms Cas Number PubMed IDs
Dodecanoic acid
  • 1-Undecanecarboxylate
143-07-7
Myristic acid
  • 1-Tridecanecarboxylate
544-63-8
Oleic acid
  • (9Z)-9-Octadecenoate
112-80-1
Palmitic acid
  • Hexaectylic acid
57-10-3
Palmitoleic acid
  • (Z)-9-Hexadecenoate
373-49-9
genes like me logo Genes that share compounds with OLAH: view

Transcripts for OLAH Gene

Unigene Clusters for OLAH Gene

Oleoyl-ACP hydrolase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OLAH Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for OLAH Gene

GeneLoc Exon Structure for
OLAH
ECgene alternative splicing isoforms for
OLAH

Expression for OLAH Gene

mRNA expression in normal human tissues for OLAH Gene

mRNA differential expression in normal tissues according to GTEx for OLAH Gene

This gene is overexpressed in Whole Blood (36.6) and Testis (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for OLAH Gene

SOURCE GeneReport for Unigene cluster for OLAH Gene Hs.24309

mRNA Expression by UniProt/SwissProt for OLAH Gene

Q9NV23-SAST_HUMAN
Tissue specificity: Isoform 2 is up-regulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.
genes like me logo Genes that share expressions with OLAH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for OLAH Gene

Orthologs for OLAH Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLAH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLAH 35
  • 97.48 (n)
  • 95.47 (a)
OLAH 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OLAH 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olah 35
  • 72.7 (n)
  • 59.25 (a)
Olah 16
Olah 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLAH 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLAH 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olah 35
  • 70.47 (n)
  • 56.27 (a)
chicken
(Gallus gallus)
Aves OLAH 35
  • 59.67 (n)
  • 44.03 (a)
OLAH 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olah 35
  • 57.47 (n)
  • 47.6 (a)
zebrafish
(Danio rerio)
Actinopterygii olah 35
  • 51.47 (n)
  • 41.2 (a)
olah 36
  • 40 (a)
OneToOne
Species with no ortholog for OLAH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLAH Gene

ENSEMBL:
Gene Tree for OLAH (if available)
TreeFam:
Gene Tree for OLAH (if available)

Paralogs for OLAH Gene

No data available for Paralogs for OLAH Gene

Variants for OLAH Gene

Sequence variations from dbSNP and Humsavar for OLAH Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1326204 -- 15,064,160(-) AATTA(A/G)TTTAA intron-variant
rs1326205 -- 15,064,067(-) CCCTG(A/G)AAATT intron-variant
rs1326206 -- 15,063,780(-) atatt(A/G)tttat intron-variant
rs1935391 -- 15,054,449(+) CTTCT(A/G)CAAGA intron-variant
rs2400119 -- 15,068,419(+) TGGAG(C/T)TTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLAH Gene

Variant ID Type Subtype PubMed ID
nsv831793 CNV Loss 17160897
nsv831794 CNV Loss 17160897
dgv618n71 CNV Gain 21882294

Relevant External Links for OLAH Gene

HapMap Linkage Disequilibrium report
OLAH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLAH Gene

Disorders for OLAH Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for OLAH Gene including...

Search for OLAH Gene in MalaCards »

Relevant External Links for OLAH

Genetic Association Database (GAD)
OLAH
Human Genome Epidemiology (HuGE) Navigator
OLAH
genes like me logo Genes that share disorders with OLAH: view

No data available for UniProtKB/Swiss-Prot for OLAH Gene

Publications for OLAH Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  4. Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. (PMID: 17082220) Nakamura N. … Ochi T. (DNA Res. 2006) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for OLAH Gene

Sources for OLAH Gene

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