OLAH Gene
protein-coding GIFtS: 47
GCID: GC10P015074
|
|
oleoyl-ACP hydrolase(Previous name: thioesterase domain containing 1 )
(Previous symbol: THEDC1)
| |
Aliases
for OLAH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oleoyl-ACP Hydrolase1 2 3 | | Thioesterase II2 3 | | THEDC11 2 3 | | AURA12 3 | | SAST1 2 | | FLJ111061 | | Thioesterase Domain Containing 11 2 | | S-Acyl Fatty Acid Synthase Thioesterase, Medium Chain2 | | Augmented In Rheumatoid Arthritis 12 3 | | EC 3.1.2.143 | | Thioesterase Domain-Containing Protein 12 3 | | |
Export aliases for OLAH gene to outside databasesPrevious GC identifers: GC10P015126 GC10P014996 |
Summaries
for OLAH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23Function: In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved byhydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain lengthof the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in theuropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids(C8 to C2) (By similarity)
|
Genomic Views
for OLAH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OLAH gene promoter:
Bach1 SRF POU2F1 SRF (504 AA) POU2F1a YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OLAH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLAH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p13OLAH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P015074: view genomic region
(about GC identifiers)
Start:
|
15,074,226 bp from pter |
End:
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15,115,851 bp from pter |
Size:
|
41,626 bases |
Orientation:
|
plus strand |
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Proteins
for OLAH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23 (See
protein sequence)Recommended Name: S-acyl fatty acid synthase thioesterase, medium chain Size: 265 amino acids; 29931 Da
Secondary accessions: Q5VUB6 Q9NUW1Alternative splicing: 2 isoforms: Q9NV23-1 Q9NV23-2 Explore the universe of human proteins at neXtProt for OLAH: NX_Q9NV23
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NV23
OLAH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001034791.1 NP_060794.1
ENSEMBL proteins: ENSP00000399290 ENSP00000399449 ENSP00000399663 ENSP00000367473 ENSP00000367470 ENSP00000367462
Human Recombinant Protein Products:
OLAH Antibody Products:
Assay Products for OLAH: |
Protein
Domains /
Families
for OLAH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OLAH for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NV23ProtoNet protein and cluster: Q9NV23 1 Blocks protein family: IPB001031 Thioesterase
UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23Similarity: Belongs to the thioesterase family |
Function
for OLAH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23Function: In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved byhydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain lengthof the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in theuropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids(C8 to C2) (By similarity)Catalytic activity: Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleateEnzyme Number (IUBMB): EC 3.1.2.141
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OLAH (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OLAH (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for OLAH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLAH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLAH |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004320 | oleoyl-[acyl-carrier-protein] hydrolase activity |
IEA | -- | | GO:0016295 | myristoyl-[acyl-carrier-protein] hydrolase activity |
IEA | -- | | GO:0016296 | palmitoyl-[acyl-carrier-protein] hydrolase activity |
IEA | -- | | GO:0016787 | hydrolase activity |
-- | -- | | GO:0016788 | hydrolase activity, acting on ester bonds |
-- | -- |
OLAH for ontologies About GeneDecksing
|
Pathways & Interactions
for OLAH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Saturated fatty acid biosynthesis | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for OLAH):
OLAH for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OLAH
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for OLAH (ENSP000003674624) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006633 | fatty acid biosynthetic process |
IEA | -- | | GO:0009058 | biosynthetic process |
-- | -- |
OLAH for ontologies About GeneDecksing
|
Drugs & Compounds
for OLAH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OLAH
7 HMDB Compounds for OLAH About this table
Search CenterWatch for drugs/clinical trials and news about OLAH / SAST
|
Transcripts
for OLAH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OLAH gene (2 alternative transcripts): NM_001039702.2 NM_018324.2 Unigene Cluster for OLAH: Oleoyl-ACP hydrolase Hs.24309 [show with all ESTs]Unigene Representative Sequence: NM_0183248 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000428897 ENST00000413672 ENST00000429028 ENST00000378228(uc001inu.2)
ENST00000378225 ENST00000378217(uc001int.2) ENST00000493912 ENST00000485251
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OLAH (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OLAH (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): OLAH (NM_001039702) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OLAH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLAH |
Additional cDNA sequence: AK001844.1 AK001968.1 BC050372.1 8 DOTS entries: DT.91724773 DT.310766 DT.100751709 DT.75135089 DT.100751708 DT.121258176 DT.91724767 DT.95370676 24/47 AceView cDNA sequences (see all 47): BE782959 AA470066 AI151217 AA431387 AK001844 BM554164 BQ013235 BX118351 BC050372 AI125816 BG475148 CB990877 AI125696 AU137095 AK001968 AI183402 AI247444 BU167548 BF125008 AI208288 NM_018324 CB991118 BE781387 AA758593
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for OLAH About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for OLAH
|
Expression
for OLAH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OLAH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTAGTAAAT
About this image
See OLAH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OLAH
SOURCE GeneReport for Unigene cluster: Hs.24309
UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23Tissue specificity: Isoform 2 is up-regulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients
SABiosciences Custom PCR Arrays for OLAH
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OLAH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OLAH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLAH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLAH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLAH |
Orthologs
for OLAH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OLAH gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for OLAH (if available)
TreeFam Gene Tree for OLAH (if available) |
Paralogs
for OLAH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for OLAH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OLAH (15074226 - 15115851 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OLAH: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OLAH |
|
Disorders
/ Diseases
for OLAH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OLAH for disorders About GeneDecksing
5  diseases for OLAH: About MalaCardsrheumatoid arthritis arthritis alzheimer's disease tuberculosis
mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: OLAH (7 documents)
Export disorders for OLAH gene to outside databases
|
Publications
for OLAH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OLAH gene integrated from 9 sources:
(articles sorted by number of sources associating them with OLAH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. (PubMed id 17082220)1, 2 Nakamura N.... Ochi T. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for OLAH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OLAH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OLAH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OLAH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OLAH | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OLAH gene:
Search GeneIP for patents involving OLAH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OLAH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OLAH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OLAH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OLAH | | | OriGene Protein Over-expression Lysate for OLAH | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OLAH | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OLAH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OLAH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for OLAH | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OLAH | | OriGene Custom Protein Services for OLAH | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OLAH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OLAH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLAH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OLAH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLAH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLAH |
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 |  |  |  | |
| | | | Search Tocris compounds for OLAH |
| |  |  |  |  | | | | |
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 |
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 | | | OLAH Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLAH |
|  |  |  | | | | Search ThermoFisher Antibodies for OLAH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLAH |
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