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Aliases for OLAH Gene

Aliases for OLAH Gene

  • Oleoyl-ACP Hydrolase 2 3 4 5
  • S-Acyl Fatty Acid Synthase Thioesterase, Medium Chain 2 3
  • Thioesterase Domain-Containing Protein 1 3 4
  • Oleoyl-Acyl-Carrier-Protein Hydrolase 2 3
  • Augmented In Rheumatoid Arthritis 1 3 4
  • Thioesterase Domain Containing 1 2 3
  • Thioesterase II 3 4
  • THEDC1 3 4
  • AURA1 3 4
  • EC 3.1.2.14 4
  • SAST 3

External Ids for OLAH Gene

Previous HGNC Symbols for OLAH Gene

  • THEDC1

Previous GeneCards Identifiers for OLAH Gene

  • GC10P015126
  • GC10P014996

Summaries for OLAH Gene

GeneCards Summary for OLAH Gene

OLAH (Oleoyl-ACP Hydrolase) is a Protein Coding gene. Diseases associated with OLAH include Rheumatoid Arthritis and Migraine With Or Without Aura 1. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include hydrolase activity, acting on ester bonds and myristoyl-[acyl-carrier-protein] hydrolase activity.

UniProtKB/Swiss-Prot for OLAH Gene

  • In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity).

Additional gene information for OLAH Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLAH Gene

Genomics for OLAH Gene

Regulatory Elements for OLAH Gene

Enhancers for OLAH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H015122 1.1 FANTOM5 ENCODE 10.5 +91.6 91561 1 HDGF PKNOX1 MAX EBF1 BATF RELA GATA3 POLR2A ZNF143 FOS ACBD7 C10orf111 RPP38 GAPDHP45 DCLRE1CP1 OLAH GC10P015124 GC10P015108
GH10H015151 0.9 ENCODE 10.5 +120.2 120221 2 ELF3 ARID4B DMAP1 RAD21 RARA YY1 CREM MIXL1 THAP11 SP5 RPP38 GAPDHP45 C10orf111 OLAH CDNF HSPA14 ACBD7 PPIAP30 GC10P015124
GH10H015106 0.7 ENCODE 10.5 +74.5 74499 0 CTCF IRF2 RB1 ARNT ARID4B RAD21 GATA3 SMC3 ZNF143 PRDM10 OLAH C10orf111 RPP38 ACBD7 GC10P015108 LOC105376431
GH10H015013 0.6 ENCODE 4.8 -18.5 -18491 0 ZNF217 CTBP1 JUND NFIB FOS RCOR1 DPF2 OLAH GC10P015013
GH10H015207 1.2 FANTOM5 Ensembl ENCODE 1.2 +176.3 176272 1 IRF2 CBFB ZNF10 ZBTB40 CREB1 ETV6 MLLT1 RUNX3 MEIG1 NMT2 CDNF OLAH C10orf111 LOC105376433 LOC105376434
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OLAH on UCSC Golden Path with GeneCards custom track

Genomic Location for OLAH Gene

Chromosome:
10
Start:
15,032,227 bp from pter
End:
15,073,852 bp from pter
Size:
41,626 bases
Orientation:
Plus strand

Genomic View for OLAH Gene

Genes around OLAH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLAH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLAH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLAH Gene

Proteins for OLAH Gene

  • Protein details for OLAH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV23-SAST_HUMAN
    Recommended name:
    S-acyl fatty acid synthase thioesterase, medium chain
    Protein Accession:
    Q9NV23
    Secondary Accessions:
    • Q5VUB6
    • Q9NUW1

    Protein attributes for OLAH Gene

    Size:
    265 amino acids
    Molecular mass:
    29931 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OLAH Gene

    Alternative splice isoforms for OLAH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLAH Gene

Post-translational modifications for OLAH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OLAH Gene

Domains & Families for OLAH Gene

Gene Families for OLAH Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for OLAH Gene

Suggested Antigen Peptide Sequences for OLAH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NV23

UniProtKB/Swiss-Prot:

SAST_HUMAN :
  • Belongs to the thioesterase family.
Family:
  • Belongs to the thioesterase family.
genes like me logo Genes that share domains with OLAH: view

Function for OLAH Gene

Molecular function for OLAH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate.
UniProtKB/Swiss-Prot Function:
In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity).

Enzyme Numbers (IUBMB) for OLAH Gene

Phenotypes From GWAS Catalog for OLAH Gene

Gene Ontology (GO) - Molecular Function for OLAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity IEA --
GO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity IEA --
GO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity IEA --
GO:0016297 acyl-[acyl-carrier-protein] hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with OLAH: view
genes like me logo Genes that share phenotypes with OLAH: view

Animal Models for OLAH Gene

MGI Knock Outs for OLAH:
  • Olah tm1b(KOMP)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OLAH
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OLAH Gene

Localization for OLAH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLAH gene
Compartment Confidence
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for OLAH Gene

Pathways & Interactions for OLAH Gene

genes like me logo Genes that share pathways with OLAH: view

Interacting Proteins for OLAH Gene

Gene Ontology (GO) - Biological Process for OLAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0008610 lipid biosynthetic process IBA --
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with OLAH: view

No data available for SIGNOR curated interactions for OLAH Gene

Drugs & Compounds for OLAH Gene

(7) Drugs for OLAH Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist 0
Water Approved Pharma 0
lauric acid Experimental Pharma Agonist 0
Myristic acid Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
genes like me logo Genes that share compounds with OLAH: view

Transcripts for OLAH Gene

Unigene Clusters for OLAH Gene

Oleoyl-ACP hydrolase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OLAH
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OLAH Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for OLAH Gene

GeneLoc Exon Structure for
OLAH
ECgene alternative splicing isoforms for
OLAH

Expression for OLAH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLAH Gene

mRNA differential expression in normal tissues according to GTEx for OLAH Gene

This gene is overexpressed in Whole Blood (x36.6) and Testis (x4.2).

Protein differential expression in normal tissues from HIPED for OLAH Gene

This gene is overexpressed in Milk (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OLAH Gene



Protein tissue co-expression partners for OLAH Gene

NURSA nuclear receptor signaling pathways regulating expression of OLAH Gene:

OLAH

SOURCE GeneReport for Unigene cluster for OLAH Gene:

Hs.24309

mRNA Expression by UniProt/SwissProt for OLAH Gene:

Q9NV23-SAST_HUMAN
Tissue specificity: Isoform 2 is up-regulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.

Evidence on tissue expression from TISSUES for OLAH Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with OLAH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLAH Gene

Orthologs for OLAH Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLAH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLAH 33 34
  • 97.48 (n)
mouse
(Mus musculus)
Mammalia Olah 33 16 34
  • 72.7 (n)
rat
(Rattus norvegicus)
Mammalia Olah 33
  • 70.47 (n)
cow
(Bos Taurus)
Mammalia OLAH 34
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLAH 34
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLAH 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLAH 33 34
  • 59.67 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia olah 33
  • 57.47 (n)
zebrafish
(Danio rerio)
Actinopterygii olah 33 34
  • 51.47 (n)
Species where no ortholog for OLAH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLAH Gene

ENSEMBL:
Gene Tree for OLAH (if available)
TreeFam:
Gene Tree for OLAH (if available)

Paralogs for OLAH Gene

No data available for Paralogs for OLAH Gene

Variants for OLAH Gene

Sequence variations from dbSNP and Humsavar for OLAH Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000029838 -- 15,048,992(+) CAACT(A/C)CATGG intron-variant
rs1000081762 -- 15,048,677(+) TCTCC(A/G)AATTG intron-variant
rs1000169350 -- 15,064,920(+) CCAAA(G/T)TGCTG intron-variant
rs1000289185 -- 15,070,820(+) TTACT(C/T)TGTTG intron-variant
rs1000292920 -- 15,043,267(+) CCTAC(A/G)TGATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OLAH Gene

Variant ID Type Subtype PubMed ID
nsv831793 CNV loss 17160897
nsv831794 CNV loss 17160897

Variation tolerance for OLAH Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLAH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLAH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLAH Gene

Disorders for OLAH Gene

MalaCards: The human disease database

(2) MalaCards diseases for OLAH Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • rheumatoid arthritis, progression of
migraine with or without aura 1
  • migraine
- elite association - COSMIC cancer census association via MalaCards
Search OLAH in MalaCards View complete list of genes associated with diseases

Relevant External Links for OLAH

Genetic Association Database (GAD)
OLAH
Human Genome Epidemiology (HuGE) Navigator
OLAH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLAH
genes like me logo Genes that share disorders with OLAH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OLAH Gene

Publications for OLAH Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60
  2. Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. (PMID: 17082220) Nakamura N … Ochi T (DNA research : an international journal for rapid publication of reports on genes and genomes 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60

Products for OLAH Gene

Sources for OLAH Gene

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