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Aliases & Descriptions for OLAH
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases AURA1 2 EC 3.1.2.14 3 FLJ11106 1 , 2 MGC51852 2 OTTHUMP00000019191 2 OTTHUMP00000019192 2 SAST 1 , 2 THEDC1 2 , 3
Descriptions Thioesterase II 3 Thioesterase domain-containing protein 1 3 augmented in rheumatoid arthritis 1 2 oleoyl-ACP hydrolase 2 , 3 thioesterase domain containing 1 1 , 2
Search outside databases for aliases for OLAH gene
Summaries for OLAH (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23 Function : In fatty acid biosynthesis chain termination and release of the free fatty acid productis achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acidsynthetase complex. The chain length of the released fatty acid is usually C16. However, in themammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl thereexists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (Bysimilarity)
Genomic Location for OLAH
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the OLAH gene Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p13 OLAH Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P015126:
(about GC identifiers )
Start:
15,125,932 bp from pter
End:
15,155,857 bp from pter
Size:
29,926 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000010.9 NT_077569.2 Proteins for OLAH
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23 (See
protein sequence )Recommended Name: S-acyl fatty acid synthase thioesterase, medium chain Size : 265 amino acids; 29931 Da
REFSEQ proteins (2 alternative transcripts):
NP_001034791.1 NP_060794.1 ENSEMBL proteins: ENSP00000367462 ENSP00000367470 ENSP00000367473 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: OLAH Antibodies for OLAH: Assays for OLAH:
Protein
Domains/ Families for OLAH(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9NV23 ProtoNet protein and cluster: Q9NV23
1 Blocks protein family : IPB001031 Thioesterase UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23 Similarity : Belongs to the thioesterase family
Gene Function for OLAH
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_018324 Applied Biosystems Silencer ® siRNAs for OLAH Sigma-Aldrich siRNA for OLAH Sigma-Aldrich shRNA for OLAH Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001039702                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001039702                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001039702  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018324 UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23 Function : In fatty acid biosynthesis chain termination and release of the free fatty acid productis achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acidsynthetase complex. The chain length of the released fatty acid is usually C16. However, in themammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl thereexists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (Bysimilarity) Catalytic activity : Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleateEnzyme Number (IUBMB): EC 3.1.2.14
2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity
IEA -- GO:0016788 hydrolase activity, acting on ester bonds
IEA --
About this table
Pathways & Interactions for OLAH
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for OLAH (Your Favorite Gene powered by Ingenuity) 5/7 Interacting proteins for OLAH (ENSP00000367462 3 ) via UniProtKB, MINT, and/or STRING (see all 7
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006633 fatty acid biosynthetic process
IEA --
About this table
Drugs & Compounds for OLAH (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for OLAH
Transcripts for OLAH(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_018324 Sigma-Aldrich siRNA for OLAH Sigma-Aldrich shRNA for OLAH Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001039702 NM_018324
REFSEQ mRNAs for OLAH gene (2 alternative transcripts): NM_001039702.2 NM_018324.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001039702 NM_018324
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001039702                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001039702                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001039702  
Additional cDNA sequence: AK001844.1 AK001968.1 BC050372.1
8 DOTS entries : DT.91724773 DT.310766 DT.100751709 DT.75135089 DT.100751708 DT.121258176 DT.91724767 DT.95370676
24/47 AceView cDNA sequences (see all 47
):AA431387 AI151217 BX118351 AA470066 BQ013235 BM554164 BC050372 AI125816 AK001844 BE782959 AU137095 BG475148 BU167548 AI208288 AI183402 AA758593 BF125008 AK001968 AA432379 BE781387 AI125696 NM_018324 CB991118 AA694484
highest scoring ESTs for OLAH :AI125696 AA470066 AA694484 AA758593 AA993723 AI025682 AI125816 AI151217 AI208288 AI219027
Unigene Cluster for OLAH: Oleoyl-ACP hydrolase Hs.24309 [show with all ESTs ] Unigene Representative Sequence: NM_018324 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for OLAH ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 SP1 :       -       -       -         SP2 :       -                     SP3 :             -               SP4 :                          
About this scheme ECgene alternative splicing isoforms for OLAH 3 Ensembl transcripts including schematic representations : ENST00000378217
ENST00000378225
ENST00000378228
Expression for OLAH
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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OLAH expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for OLAH 1 / 2 / 3
7 probe-sets matching OLAH gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ATTAGTAAATSOURCE GeneReport for Unigene cluster: Hs.24309
Orthologs for OLAH
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for OLAH gene from 5 species
About this table Species with no ortholog for OLAH ENSEMBL Gene Tree for OLAH Paralogs for OLAH (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for OLAH (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for OLAH (up to first 250kb)
Disorders & Mutations for OLAH
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Medical News for OLAH (Possibly Related Articles in
Doctor's Guide )
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Publications for OLAH (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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4 PubMed articles for OLAH gene :
Search for OLAH
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing OLAH
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing OLAH
(According to HUGE )
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Specialized Databases showing OLAH (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for OLAH (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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