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OLAH Gene

protein-coding   GIFtS: 50
GCID: GC10P015074

Oleoyl-ACP Hydrolase

(Previous name: thioesterase domain containing 1)
(Previous symbol: THEDC1)
  See OLAH-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oleoyl-ACP Hydrolase1 2 3     Thioesterase II2 3
THEDC11 2 3     AURA12 3
Thioesterase Domain Containing 11 2     SAST2
Augmented In Rheumatoid Arthritis 12 3     S-Acyl Fatty Acid Synthase Thioesterase, Medium Chain2
Thioesterase Domain-Containing Protein 12 3     EC 3.1.2.143

External Ids:    HGNC: 256251   Entrez Gene: 553012   Ensembl: ENSG000001524637   UniProtKB: Q9NV233   

Export aliases for OLAH gene to outside databases

Previous GC identifers: GC10P015126 GC10P014996


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OLAH Gene:
OLAH (oleoyl-ACP hydrolase) is a protein-coding gene. Diseases associated with OLAH include arthritis, and rheumatoid arthritis. GO annotations related to this gene include oleoyl-[acyl-carrier-protein] hydrolase activity and palmitoyl-[acyl-carrier-protein] hydrolase activity.

UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23
Function: In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by
hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain
length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in
the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length
fatty acids (C8 to C2) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OLAH gene promoter:
         Bach1   SRF   POU2F1   SRF (504 AA)   POU2F1a   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOLAH promoter sequence
   Search Chromatin IP Primers for OLAH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OLAH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

OLAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLAH gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P015074:  view genomic region     (about GC identifiers)

Start:
15,074,226 bp from pter      End:
15,115,851 bp from pter
Size:
41,626 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23 (See protein sequence)
Recommended Name: S-acyl fatty acid synthase thioesterase, medium chain  
Size: 265 amino acids; 29931 Da
Secondary accessions: Q5VUB6 Q9NUW1
Alternative splicing: 2 isoforms:  Q9NV23-1   Q9NV23-2   

Explore the universe of human proteins at neXtProt for OLAH: NX_Q9NV23

Explore proteomics data for OLAH at MOPED


See OLAH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001034791.1  NP_060794.1  

ENSEMBL proteins: 
 ENSP00000399290   ENSP00000399449   ENSP00000399663   ENSP00000367473   ENSP00000367470  
 ENSP00000367462  

OLAH Human Recombinant Protein Products:

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antibodies-online proteins for OLAH (3 products) 

 
antibodies-online peptides for OLAH

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antibodies-online antibodies for OLAH (6 products) 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR012223 TEII
 IPR001031 Thioesterase

Graphical View of Domain Structure for InterPro Entry Q9NV23

ProtoNet protein and cluster: Q9NV23

1 Blocks protein domain: IPB001031 Thioesterase

UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23
Similarity: Belongs to the thioesterase family


Find genes that share domains with OLAH           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SAST_HUMAN, Q9NV23
Function: In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by
hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain
length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in
the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length
fatty acids (C8 to C2) (By similarity)
Catalytic activity: Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate

     Enzyme Number (IUBMB): EC 3.1.2.141

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004320oleoyl-[acyl-carrier-protein] hydrolase activity IEA--
GO:0016295myristoyl-[acyl-carrier-protein] hydrolase activity IEA--
GO:0016296palmitoyl-[acyl-carrier-protein] hydrolase activity IEA--
GO:0016788hydrolase activity, acting on ester bonds ----
     
Find genes that share ontologies with OLAH           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Olah (no phenotypes)

Find genes that share phenotypes with OLAH           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OLAH
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miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
chloroplast1
cytosol1
extracellular1
mitochondrion1
nucleus1
peroxisome1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OLAH About    
See pathways by source

SuperPathContained pathways About
1Fatty acid metabolism
Fatty acid metabolism0.42
Fatty acid biosynthesis0.00
2Metabolism
Metabolic pathways0.38


Find genes that share SuperPaths with OLAH           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways




3 Kegg Pathways  (Kegg details for OLAH):
    Fatty acid biosynthesis
Metabolic pathways
Fatty acid metabolism

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OLAH
Interactions:

    Search GeneGlobe Interaction Network for OLAH

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for OLAH (ENSP000003674624) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
FASNENSP000003045924STRING: ENSP00000304592
OXSMENSP000002807014STRING: ENSP00000280701
CAP1ENSP000003618784STRING: ENSP00000361878
DNAJC1ENSP000003661794STRING: ENSP00000366179
ENSG00000226467ENSP000004058644STRING: ENSP00000405864
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006633fatty acid biosynthetic process IEA--
GO:0009058biosynthetic process ----

Find genes that share ontologies with OLAH           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for OLAH (SAST)

7 HMDB Compounds for OLAH    About this table
CompoundSynonyms CAS #PubMed Ids
Dodecanoic acid1-Undecanecarboxylate (see all 28)143-07-7--
Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
Oleic acid(9Z)-9-Octadecenoate (see all 67)112-80-1--
Palmitic acidHexaectylic acid (see all 45)57-10-3--
Palmitoleic acid(Z)-9-Hexadecenoate (see all 23)373-49-9--
Stearic acid1-Heptadecanecarboxylate (see all 12)57-11-4--
WaterDihydrogen oxide (see all 2)7732-18-5--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OLAH gene (2 alternative transcripts): 
NM_001039702.2  NM_018324.2  

Unigene Cluster for OLAH:

Oleoyl-ACP hydrolase
Hs.24309  [show with all ESTs]
Unigene Representative Sequence: NM_018324
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000428897 ENST00000413672 ENST00000429028 ENST00000378228(uc001inu.2)
ENST00000378225 ENST00000378217(uc001int.2) ENST00000493912 ENST00000485251

miRNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLAH
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  QuantiFast Probe-based Assays in human, mouse, rat OLAH

Additional mRNA sequence: 

AK001844.1 AK001968.1 BC050372.1 

8 DOTS entries:

DT.91724773  DT.310766  DT.100751709  DT.75135089  DT.100751708  DT.121258176  DT.91724767  DT.95370676 

Selected AceView cDNA sequences (see all 47):

BX118351 AK001844 AA431387 BE782959 AI151217 AA470066 BQ013235 AI125816 
BC050372 BM554164 AU137095 CB991118 AA694484 AU135292 BE781387 AI183402 
AI247444 AI208288 BU167548 AK001968 AA432379 AA758593 NM_018324 BF125008 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for OLAH    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:                    -                 -                 -                     
SP2:                    -                                                         
SP3:                                      -                                       
SP4:                                                                              


ECgene alternative splicing isoforms for OLAH

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OLAH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATTAGTAAAT
OLAH Expression
About this image

OLAH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OLAH Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.24309

UniProtKB/Swiss-Prot: SAST_HUMAN, Q9NV23
Tissue specificity: Isoform 2 is up-regulated in bone marrow-derived mononuclear cells of rheumatoid arthritis
patients

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLAH

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for OLAH gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olah1 , 5 oleoyl-ACP hydrolase1, 5 72.7(n)1
59.25(a)1
  2 (1.88 cM)5
990351  NM_145921.11  NP_666033.11 
 33419825 
chicken
(Gallus gallus)
Aves OLAH1 oleoyl-ACP hydrolase 59.67(n)
44.03(a)
  420532  XM_004939263.1  XP_004939320.1 
tropical clawed frog
(Xenopus tropicalis)
Amphibia olah1 oleoyl-ACP hydrolase 57.47(n)
47.6(a)
  407865  NM_001001207.1  NP_001001207.1 
zebrafish
(Danio rerio)
Actinopterygii olah1 oleoyl-ACP hydrolase 51.47(n)
41.2(a)
  568096  NM_001039932.1  NP_001035021.1 


ENSEMBL Gene Tree for OLAH (if available)
TreeFam Gene Tree for OLAH (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OLAH (see all 747)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs727743471,2
C,F--15083928(+) AGTTAC/TGTCTT 2 -- us2k15Minor allele frequency- T:0.14WA NA EA 362
rs1905012771,2
--15084010(+) TGCTAA/GTGATT 2 -- us2k10--------
rs1457985981,2
C--15084076(+) GTAATA/TGAGTT 2 -- us2k10--------
rs37637821,2
C--15084265(+) CCTGCC/TTCAGC 2 -- us2k13Minor allele frequency- T:0.17NA 6
rs1819827041,2
--15084312(+) CGCCCA/CGCTAA 2 -- us2k10--------
rs37637831,2
C,F,A--15084471(+) ATACAG/CGCATG 2 -- us2k1 tfbs38Minor allele frequency- C:0.31NA CSA WA EA 368
rs37637841,2
C,F,H--15084490(+) TGTCAC/TGGAGA 2 -- us2k1 tfbs319Minor allele frequency- N:0.01NS EA NA WA 1418
rs1436866771,2
--15084558(+) CTCTTA/CTAGTC 2 -- us2k10--------
rs37637851,2
C,F,H--15084568(+) CATTTT/CAGAAT 2 -- us2k110Minor allele frequency- C:0.20NS EA NA WA 756
rs3760333801,2
C--15084580(+) GTACA-/TTAAG 
        
TAAGT
2 -- us2k10--------

HapMap Linkage Disequilibrium report for OLAH (15074226 - 15115851 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for OLAH:    About this table    
Variant IDTypeSubtypePubMed ID
nsv831793CNV Loss17160897
nsv831794CNV Loss17160897
dgv618n71CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing OLAH
DNA2.0 Custom Variant and Variant Library Synthesis for OLAH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for OLAH:    
About MalaCards
arthritis    rheumatoid arthritis


Find genes that share disorders with OLAH           About GenesLikeMe

Genetic Association Database (GAD): OLAH
Human Genome Epidemiology (HuGE) Navigator: OLAH (7 documents)

Export disorders for OLAH gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OLAH gene integrated from 10 sources:
(articles sorted by number of sources associating them with OLAH)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. (PubMed id 17082220)1, 2 Nakamura N.... Ochi T. (DNA Res. 2006)
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55301 HGNC: 25625 AceView: THEDC1 Ensembl:ENSG00000152463 euGenes: HUgn55301
ECgene: OLAH Kegg: 55301 H-InvDB: OLAH

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OLAH Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OLAH gene:
Search GeneIP for patents involving OLAH

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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