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OLA1 Gene

protein-coding   GIFtS: 59
GCID: GC02M174937

Obg-Like ATPase 1

(Previous name: GTP-binding protein 9 (putative))
(Previous symbol: GTPBP9)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Obg-Like ATPase 11 2     DNA Damage-Regulated Overexpressed In Cancer 45 Protein2
GTPBP91 2 3     GTP-Binding Protein PTD0042
GTP-Binding Protein 9 (Putative)1 2     Homologous Yeast-44.2 Protein2
DOC452 3     DNA Damage-Regulated Overexpressed In Cancer 453
GTBP92 5     GTP-Binding Protein 93
GBP452     EC 3.6.38

External Ids:    HGNC: 288331   Entrez Gene: 297892   Ensembl: ENSG000001384307   OMIM: 6111755   UniProtKB: Q9NTK53   

Export aliases for OLA1 gene to outside databases

Previous GC identifers: GC02M174646 GC02M166816


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OLA1 Gene:
OLA1 (Obg-like ATPase 1) is a protein-coding gene. GO annotations related to this gene include hydrolase activity and GTP binding.

UniProtKB/Swiss-Prot: OLA1_HUMAN, Q9NTK5
Function: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP

Gene Wiki entry for OLA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the OLA1 gene promoter:
         TBP   USF1   HNF-4alpha2   Tal-1beta   HNF-4alpha1   AREB6   S8   USF-1   COMP1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOLA1 promoter sequence
   Search Chromatin IP Primers for OLA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OLA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

OLA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLA1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M174937:  view genomic region     (about GC identifiers)

Start:
174,937,175 bp from pter      End:
175,113,426 bp from pter
Size:
176,252 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OLA1_HUMAN, Q9NTK5 (See protein sequence)
Recommended Name: Obg-like ATPase 1  
Size: 396 amino acids; 44744 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for OLA1:
2OHF (3D)    
Secondary accessions: D7EHM2 Q5BJD7 Q8NCI8 Q96CU1 Q96SV2 Q9P1D3 Q9UNY9 Q9Y6G4
Alternative splicing: 3 isoforms:  Q9NTK5-1   Q9NTK5-2   Q9NTK5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OLA1: NX_Q9NTK5

Explore proteomics data for OLA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys83, Lys190, Lys281
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for OLA1 (Q9NTK5) (see all 17)
     LEKVAVR  DPGALVIP  DFKEEGSE  ACDGIFHL 


    See OLA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001011708.1  NP_037473.3  

    ENSEMBL proteins: 
     ENSP00000284719   ENSP00000340167   ENSP00000410385   ENSP00000386350   ENSP00000404864  
     ENSP00000414568  

    OLA1 Human Recombinant Protein Products:

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    Novus Biologicals OLA1 Proteins
    Novus Biologicals OLA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for OLA1
    Cloud-Clone Corp. Proteins for OLA1

     
    Search eBioscience for Proteins for OLA1 

     
    antibodies-online proteins for OLA1 (4 products) 

     
    antibodies-online peptides for OLA1

    OLA1 Antibody Products:

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    antibodies-online antibodies for OLA1 (44 products) 

    OLA1 Assay Products:

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    Cloud-Clone Corp. ELISAs for OLA1
    Cloud-Clone Corp. CLIAs for OLA1
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    antibodies-online kits for OLA1 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR012675 Beta-grasp_dom
     IPR013029 DUF933
     IPR004396 ATPase_YchF/OLA1
     IPR027417 P-loop_NTPase
     IPR012676 TGS-like

    Graphical View of Domain Structure for InterPro Entry Q9NTK5

    ProtoNet protein and cluster: Q9NTK5

    3 Blocks protein domains:
    IPB002917 GTP-binding protein
    IPB006073 GTP1/OBG GTP-binding protein family signature
    IPB013029 Protein of unknown function DUF933


    UniProtKB/Swiss-Prot: OLA1_HUMAN, Q9NTK5
    Similarity: Belongs to the GTP1/OBG family. YchF/OLA1 subfamily
    Similarity: Contains 1 G (guanine nucleotide-binding) domain


    Find genes that share domains with OLA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OLA1_HUMAN, Q9NTK5
    Function: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP
    Induction: Strongly down-regulated by DNA damage-inducing agents

         Enzyme Number (IUBMB): EC 3.6.32

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IDA17430889
    GO:0005525GTP binding IEA--
    GO:0015093ferrous iron transmembrane transporter activity ----
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with OLA1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OLA1

    miRNA
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    miRTarBase miRNAs that target OLA1:
    hsa-mir-877-3p (MIRT036907), hsa-mir-26a-5p (MIRT050153), hsa-mir-222-3p (MIRT046736)

    Block miRNA regulation of human, mouse, rat OLA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OLA1 (see all 98):
    hsa-miR-26a-2* hsa-miR-3607-3p hsa-miR-218-1* hsa-miR-605 hsa-miR-485-3p hsa-miR-376a* hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidOLA1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OLA1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: OLA1 (NM_016937)
    Sino Biological Human cDNA Clone for OLA1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLA1
    Addgene plasmids for OLA1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OLA1_HUMAN, Q9NTK5: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly cytoplasmic, shuttles between the
    nucleus and the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--
    GO:0016021integral component of membrane ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with OLA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OLA1
    Interactions:

        Search GeneGlobe Interaction Network for OLA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OLA1 (Q9NTK51, 2, 3 ENSP000002847194) via UniProtKB, MINT, STRING, and/or I2D (see all 798)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA17430889
    GO:0015684ferrous iron transport ----

    Find genes that share ontologies with OLA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OLA1

    1 HMDB Compound for OLA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OLA1 gene (2 alternative transcripts): 
    NM_001011708.1  NM_013341.3  

    Unigene Cluster for OLA1:

    Obg-like ATPase 1
    Hs.157351  [show with all ESTs]
    Unigene Representative Sequence: NM_013341
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284719(uc002uih.3 uc002uii.3 uc010fqq.3 uc010fqr.3)
    ENST00000344357 ENST00000428402 ENST00000497760 ENST00000409546 ENST00000392560
    ENST00000462000 ENST00000429575 ENST00000427472
    miRNA
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    Block miRNA regulation of human, mouse, rat OLA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OLA1 (see all 98):
    hsa-miR-26a-2* hsa-miR-3607-3p hsa-miR-218-1* hsa-miR-605 hsa-miR-485-3p hsa-miR-376a* hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidOLA1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for OLA1
    Predesigned siRNA for gene silencing in human, mouse, rat OLA1
    Clone
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    OriGene ORF clones in mouse, rat for OLA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OLA1 (NM_016937)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OLA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLA1
    Addgene plasmids for OLA1 
    Primer
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    OriGene qPCR primer pairs and template standards for OLA1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OLA1
      QuantiTect SYBR Green Assays in human, mouse, rat OLA1
      QuantiFast Probe-based Assays in human, mouse, rat OLA1

    Additional mRNA sequence: 

    AF078859.1 AF078868.1 AF090946.1 AF134478.1 AK027523.1 AK074710.1 AK225112.1 AK225138.1 
    AK296339.1 AL136546.1 AL833441.1 BC012842.1 BC013925.1 BC029376.1 BC068447.1 BC091522.1 
    DQ250006.1 

    Selected DOTS entries (see all 29):

    DT.75123637  DT.100880350  DT.100692069  DT.91777312  DT.120967622  DT.100766712  DT.91777295  DT.100880343 
    DT.100880345  DT.95368241  DT.100663964  DT.100880347  DT.120967581  DT.100880341  DT.100880351  DT.100880352 
    DT.102834815  DT.120667025  DT.120967580  DT.120967585  DT.120967657  DT.120967666  DT.120967676  DT.91777309 

    Selected AceView cDNA sequences (see all 540):

    AV716790 CA419824 BC029376 AA397578 AA236854 AL596485 BG209293 AL516522 
    BI712764 CA416548 AA761981 BM827773 AL557475 BC012842 CR606753 BQ212387 
    BG183323 AA977383 BE673167 AA588591 BI667004 BM472325 BM542668 AF134478 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OLA1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14
    SP1:                                                                    -     -                                                     -                     
    SP2:                                -                                   -     -                                                                           
    SP3:                                -     -                                   -                                                                           
    SP4:                                -     -                             -     -                                                                           
    SP5:                                -     -                             -     -           -     -     -                                                   


    ECgene alternative splicing isoforms for OLA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OLA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTACAGTA
    OLA1 Expression
    About this image

    OLA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OLA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.157351

    UniProtKB/Swiss-Prot: OLA1_HUMAN, Q9NTK5
    Tissue specificity: Expressed in all tissues tested but its expression is more abundant in testis, liver, lung,
    and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach,
    and uterus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OLA1 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ola11 , 5 Obg-like ATPase 11, 5 93.43(n)1
    99.49(a)1
      2 (43.35 cM)5
    670591  NM_025942.21  NP_080218.11 
     730928015 
    chicken
    (Gallus gallus)
    Aves OLA11 Obg-like ATPase 1 86.2(n)
    91.16(a)
      424144  NM_001031254.2  NP_001026425.1 
    lizard
    (Anolis carolinensis)
    Reptilia OLA16
    Obg-like ATPase 1
    91(a)
    1 ↔ 1
    GL343316.1(166261-349686)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC540332 hypothetical protein MGC54033 82.71(n)    BC046937.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc66b092 Danio rerio cDNA clone MGC55768 IMAGE3816932, complete more 77.41(n)    BC051155.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13541 CG1354 64.6(n)
    74.16(a)
      31914  NM_132352.4  NP_572580.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2101 tag-210 63.27(n)
    68.19(a)
      173205  NM_001267077.1  NP_001254006.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OLA1(YBR025C)4
    OLA11
    P-loop ATPase with similarity to human OLA1 and bacterial more4
    OLA11
    58.64(n)1
    55.24(a)1
      2(291865-290681)4
    8523131, 4  NP_009581.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G305801 AT1G30580 62.41(n)
    62.76(a)
      839938  NM_102795.2  NP_174346.1 
    rice
    (Oryza sativa)
    Liliopsida Os.96342 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.41(n)    AK062256.1 


    ENSEMBL Gene Tree for OLA1 (if available)
    TreeFam Gene Tree for OLA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OLA1 gene
    1 SIMAP similar gene for OLA1 using alignment to 4 protein entries:     OLA1_HUMAN (see all proteins):
    PTD004

    Find genes that share paralogs with OLA1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for OLA1 (see all 6)
    PGOHUM00000239473 PGOHUM00000239474 PGOHUM00000237296 PGOHUM00000237297 PGOHUM00000246342


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OLA1 (see all 3070)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0366134
    A breast cancer sample4--see VAR_0366132 E Q mis40--------
    rs1432648451,2
    --174936684(+) TACAGA/GCGAGG 2 -- ds50010--------
    rs1878074311,2
    --174936732(+) AGGTCA/GTACAA 2 -- ds50010--------
    rs1467067711,2
    --174936780(+) CTGACC/TCCTGA 2 -- ds50010--------
    rs124667881,2
    C,F,A,H--174936851(+) ACTTGC/TCATTC 2 -- ds500114Minor allele frequency- T:0.31NS EA NA WA CSA 781
    rs575879081,2
    F--174936880(+) CTTAGA/GTGTTT 2 -- ds50011Minor allele frequency- G:0.03WA 118
    rs133931801,2
    C,F--174936894(+) AAGTGT/CTATAA 2 -- ds50015Minor allele frequency- C:0.15WA CSA NA 243
    rs1400498721,2
    --174936907(+) CGGCAC/TTGCTG 2 -- ds50010--------
    rs1144319871,2
    C,F--174936989(+) GAAGCG/CCTTGC 2 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1915591831,2
    --174937012(+) CACGTG/TAGTCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for OLA1 (174937175 - 175113426 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OLA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721155CNV Deletion23290073
    esv991222CNV Deletion20482838
    esv3866CNV Deletion18987735
    esv273879CNV Insertion20981092
    esv5452CNV Loss19470904
    nsv3040CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for OLA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611175    OMIM disorders: --


    Find genes that share disorders with OLA1           About GenesLikeMe

    Genetic Association Database (GAD): OLA1
    Human Genome Epidemiology (HuGE) Navigator: OLA1 (1 document)

    Export disorders for OLA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OLA1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with OLA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human OLA1 defines an ATPase subfamily in the Obg family of GTP- binding proteins. (PubMed id 17430889)1, 2, 3 Koller-Eichhorn R.... Kambach C. (J. Biol. Chem. 2007)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies. (PubMed id 20053727)1, 2 Sun H.... Huang Y. (Mol. Cancer Res. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    7. The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation. (PubMed id 24289923)1 Matsuzawa A....Chiba N. (Mol. Cell 2014)
    8. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    9. OLA1 protects cells in heat shock by stabilizing HSP70. (PubMed id 23412384)1 Mao R.F....Shi Z.Z. (amp 2013)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29789 HGNC: 28833 AceView: PTD004 Ensembl:ENSG00000138430 euGenes: HUgn29789
    ECgene: OLA1 H-InvDB: OLA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OLA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OLA1 gene:
    Search GeneIP for patents involving OLA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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