Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OLA1 Gene

Aliases for OLA1 Gene

  • Obg-Like ATPase 1 2 3 5
  • GTP-Binding Protein 9 (Putative) 2 3
  • GTPBP9 3 4
  • DOC45 3 4
  • DNA Damage-Regulated Overexpressed In Cancer 45 Protein 3
  • DNA Damage-Regulated Overexpressed In Cancer 45 4
  • Homologous Yeast-44.2 Protein 3
  • GTP-Binding Protein PTD004 3
  • GTP-Binding Protein 9 4
  • EC 3.6.3 63
  • PTD004 3
  • GBP45 3
  • GTBP9 3

External Ids for OLA1 Gene

Previous HGNC Symbols for OLA1 Gene

  • GTPBP9

Previous GeneCards Identifiers for OLA1 Gene

  • GC02M174646
  • GC02M174937
  • GC02M166816

Summaries for OLA1 Gene

GeneCards Summary for OLA1 Gene

OLA1 (Obg-Like ATPase 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding and ribosome binding.

UniProtKB/Swiss-Prot for OLA1 Gene

  • Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.

Gene Wiki entry for OLA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLA1 Gene

Genomics for OLA1 Gene

Regulatory Elements for OLA1 Gene

Enhancers for OLA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OLA1 on UCSC Golden Path with GeneCards custom track

Promoters for OLA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OLA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OLA1 Gene

174,072,447 bp from pter
174,248,698 bp from pter
176,252 bases
Minus strand

Genomic View for OLA1 Gene

Genes around OLA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLA1 Gene

Proteins for OLA1 Gene

  • Protein details for OLA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Obg-like ATPase 1
    Protein Accession:
    Secondary Accessions:
    • D7EHM2
    • Q5BJD7
    • Q8NCI8
    • Q96CU1
    • Q96SV2
    • Q9P1D3
    • Q9UNY9
    • Q9Y6G4

    Protein attributes for OLA1 Gene

    396 amino acids
    Molecular mass:
    44744 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for OLA1 Gene

    Alternative splice isoforms for OLA1 Gene


neXtProt entry for OLA1 Gene

Proteomics data for OLA1 Gene at MOPED

Post-translational modifications for OLA1 Gene

  • Ubiquitination at Lys 83, Lys 190, and Lys 281
  • Modification sites at PhosphoSitePlus

Other Protein References for OLA1 Gene

Domains & Families for OLA1 Gene

Suggested Antigen Peptide Sequences for OLA1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
genes like me logo Genes that share domains with OLA1: view

No data available for Gene Families for OLA1 Gene

Function for OLA1 Gene

Molecular function for OLA1 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
UniProtKB/Swiss-Prot Induction:
Strongly down-regulated by DNA damage-inducing agents.

Enzyme Numbers (IUBMB) for OLA1 Gene

Gene Ontology (GO) - Molecular Function for OLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0016887 ATPase activity IEA,IDA 17430889
GO:0043023 ribosomal large subunit binding IEA --
genes like me logo Genes that share ontologies with OLA1: view
genes like me logo Genes that share phenotypes with OLA1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OLA1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OLA1 Gene

Localization for OLA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLA1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm. {ECO:0000255 HAMAP-Rule:MF_03167}.

Subcellular locations from

Jensen Localization Image for OLA1 Gene COMPARTMENTS Subcellular localization image for OLA1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 4
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for OLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with OLA1: view

Pathways & Interactions for OLA1 Gene

SuperPathways for OLA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLA1 Gene


No data available for Pathways by source and SIGNOR curated interactions for OLA1 Gene

Drugs & Compounds for OLA1 Gene

(2) Drugs for OLA1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for OLA1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with OLA1: view

Transcripts for OLA1 Gene

Unigene Clusters for OLA1 Gene

Obg-like ATPase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OLA1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - -
SP6: -
SP7: - -

Relevant External Links for OLA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OLA1 Gene

mRNA expression in normal human tissues for OLA1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OLA1 Gene

SOURCE GeneReport for Unigene cluster for OLA1 Gene Hs.157351

mRNA Expression by UniProt/SwissProt for OLA1 Gene

Tissue specificity: Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus.
genes like me logo Genes that share expression patterns with OLA1: view

Protein tissue co-expression partners for OLA1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for OLA1 Gene

Orthologs for OLA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OLA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OLA1 35
  • 96.46 (n)
  • 99.24 (a)
OLA1 36
  • 99 (a)
(Canis familiaris)
Mammalia OLA1 35
  • 97.14 (n)
  • 100 (a)
OLA1 36
  • 100 (a)
(Mus musculus)
Mammalia Ola1 35
  • 93.43 (n)
  • 99.49 (a)
Ola1 16
Ola1 36
  • 99 (a)
(Pan troglodytes)
Mammalia OLA1 35
  • 100 (n)
  • 100 (a)
OLA1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ola1 35
  • 92.93 (n)
  • 98.23 (a)
(Monodelphis domestica)
Mammalia OLA1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia OLA1 36
  • 94 (a)
(Gallus gallus)
Aves OLA1 35
  • 86.2 (n)
  • 91.16 (a)
OLA1 36
  • 91 (a)
(Anolis carolinensis)
Reptilia OLA1 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ola1 35
  • 80.98 (n)
  • 85.86 (a)
Str.9014 35
African clawed frog
(Xenopus laevis)
Amphibia MGC54033 35
(Danio rerio)
Actinopterygii ola1 35
  • 76.18 (n)
  • 87.37 (a)
wufc66b09 35
ola1 36
  • 87 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000672 35
  • 64.08 (n)
  • 73.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1354 35
  • 64.6 (n)
  • 74.16 (a)
CG1354 36
  • 73 (a)
(Caenorhabditis elegans)
Secernentea tag-210 35
  • 63.27 (n)
  • 68.19 (a)
ola-1 36
  • 68 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL192W 35
  • 54.19 (n)
  • 54.71 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03608g 35
  • 57.59 (n)
  • 54.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLA1 35
  • 58.64 (n)
  • 55.24 (a)
OLA1 36
  • 53 (a)
OLA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G30580 35
  • 62.41 (n)
  • 62.76 (a)
(Glycine max)
eudicotyledons Gma.2708 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.724 35
(Hordeum vulgare)
Liliopsida Hv.3018 35
(Oryza sativa)
Liliopsida Os.9634 35
Os08g0199300 35
  • 61.48 (n)
  • 62.5 (a)
(Triticum aestivum)
Liliopsida Ta.2982 35
(Zea mays)
Liliopsida Zm.968 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3463 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02044 35
  • 55.58 (n)
  • 53.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC27E2.03c 35
  • 58.14 (n)
  • 52.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5782 36
  • 71 (a)
Species with no ortholog for OLA1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for OLA1 Gene

Gene Tree for OLA1 (if available)
Gene Tree for OLA1 (if available)

Paralogs for OLA1 Gene

(1) SIMAP similar genes for OLA1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OLA1: view

No data available for Paralogs for OLA1 Gene

Variants for OLA1 Gene

Sequence variations from dbSNP and Humsavar for OLA1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_036613 A breast cancer sample
rs726622 -- 174,150,377(-) ACAAG(C/G)TCAGC intron-variant
rs726623 -- 174,150,373(-) GCTCA(C/G)CGGGC intron-variant
rs1550387 -- 174,195,911(-) TTTCA(C/G)TGAAC intron-variant
rs1562312 -- 174,088,867(+) TGAAA(C/T)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLA1 Gene

Variant ID Type Subtype PubMed ID
esv273879 CNV Insertion 20981092
nsv3040 CNV Loss 18451855
esv3866 CNV Deletion 18987735
esv991222 CNV Deletion 20482838
esv2721155 CNV Deletion 23290073
esv5452 CNV Loss 19470904

Variation tolerance for OLA1 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OLA1 Gene

Disorders for OLA1 Gene

Relevant External Links for OLA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OLA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLA1 Gene

Publications for OLA1 Gene

  1. Human OLA1 defines an ATPase subfamily in the Obg family of GTP- binding proteins. (PMID: 17430889) Koller-Eichhorn R. … Kambach C. (J. Biol. Chem. 2007) 2 3 4 67
  2. Regulation of cell-matrix adhesion by OLA1, the Obg-like ATPase 1. (PMID: 24486488) Jeyabal P.V. … Shi Z.Z. (Biochem. Biophys. Res. Commun. 2014) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation. (PMID: 24289923) Matsuzawa A. … Chiba N. (Mol. Cell 2014) 3

Products for OLA1 Gene

Sources for OLA1 Gene