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Aliases for OLA1 Gene

Aliases for OLA1 Gene

  • Obg Like ATPase 1 2 3 5
  • GTP-Binding Protein 9 (Putative) 2 3
  • GTPBP9 3 4
  • DOC45 3 4
  • DNA Damage-Regulated Overexpressed In Cancer 45 Protein 3
  • DNA Damage-Regulated Overexpressed In Cancer 45 4
  • Homologous Yeast-44.2 Protein 3
  • GTP-Binding Protein PTD004 3
  • GTP-Binding Protein 9 4
  • Obg-Like ATPase 1 3
  • EC 3.6.3 61
  • PTD004 3
  • GBP45 3
  • GTBP9 3

External Ids for OLA1 Gene

Previous HGNC Symbols for OLA1 Gene

  • GTPBP9

Previous GeneCards Identifiers for OLA1 Gene

  • GC02M174646
  • GC02M174937
  • GC02M166816

Summaries for OLA1 Gene

Entrez Gene Summary for OLA1 Gene

  • This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]

GeneCards Summary for OLA1 Gene

OLA1 (Obg Like ATPase 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include GTP binding and ribosome binding.

UniProtKB/Swiss-Prot for OLA1 Gene

  • Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.

Gene Wiki entry for OLA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLA1 Gene

Genomics for OLA1 Gene

Regulatory Elements for OLA1 Gene

Enhancers for OLA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F174205 0.6 FANTOM5 15.4 +43.4 43406 0.3 OLA1 SP3 WIPF1 ENSG00000270799 RN7SL65P
GH02F174221 0.6 FANTOM5 12 +27.4 27375 0.2 OLA1 RN7SL65P ENSG00000270799
GH02F174175 1.9 VISTA ENCODE 10.4 +71.5 71459 2.6 ZNF146 RFX1 HLF IKZF1 TRIM28 SETDB1 OLA1 ENSG00000270799 RN7SL65P
GH02F174325 0.4 ENCODE 10.2 -77.5 -77501 0.8 ZNF121 EGR2 SP3 REST SP1 TFDP1 IKZF1 ZBTB33 ZBTB26 MGA OLA1 GPR155 LINC01305 SP9
GH02F174117 0.8 Ensembl ENCODE 9.8 +130.1 130069 2.2 ZNF146 JUN EP300 ETS1 ARID1B JUND ATF3 SMARCA4 PBX2 FOS OLA1 GC02P174107 GC02P174142
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OLA1 on UCSC Golden Path with GeneCards custom track

Promoters for OLA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001548994 498 2401 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143

Genomic Location for OLA1 Gene

Chromosome:
2
Start:
174,072,447 bp from pter
End:
174,248,698 bp from pter
Size:
176,252 bases
Orientation:
Minus strand

Genomic View for OLA1 Gene

Genes around OLA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLA1 Gene

Proteins for OLA1 Gene

  • Protein details for OLA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTK5-OLA1_HUMAN
    Recommended name:
    Obg-like ATPase 1
    Protein Accession:
    Q9NTK5
    Secondary Accessions:
    • D7EHM2
    • Q5BJD7
    • Q8NCI8
    • Q96CU1
    • Q96SV2
    • Q9P1D3
    • Q9UNY9
    • Q9Y6G4

    Protein attributes for OLA1 Gene

    Size:
    396 amino acids
    Molecular mass:
    44744 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for OLA1 Gene

    Alternative splice isoforms for OLA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLA1 Gene

Post-translational modifications for OLA1 Gene

  • Ubiquitination at Lys 83, Lys 190, and Lys 281
  • Modification sites at PhosphoSitePlus

Domains & Families for OLA1 Gene

Suggested Antigen Peptide Sequences for OLA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NTK5

UniProtKB/Swiss-Prot:

OLA1_HUMAN :
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
Domain:
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
genes like me logo Genes that share domains with OLA1: view

No data available for Gene Families for OLA1 Gene

Function for OLA1 Gene

Molecular function for OLA1 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
UniProtKB/Swiss-Prot Induction:
Strongly down-regulated by DNA damage-inducing agents.

Enzyme Numbers (IUBMB) for OLA1 Gene

Gene Ontology (GO) - Molecular Function for OLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0005524 ATP binding IEA,IDA 17430889
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity IEA,IDA 17430889
genes like me logo Genes that share ontologies with OLA1: view
genes like me logo Genes that share phenotypes with OLA1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OLA1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OLA1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OLA1 Gene

Localization for OLA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLA1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm. {ECO:0000255 HAMAP-Rule:MF_03167}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLA1 Gene COMPARTMENTS Subcellular localization image for OLA1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 4
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for OLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with OLA1: view

Pathways & Interactions for OLA1 Gene

genes like me logo Genes that share pathways with OLA1: view

Gene Ontology (GO) - Biological Process for OLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046034 ATP metabolic process IDA 17430889
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with OLA1: view

No data available for SIGNOR curated interactions for OLA1 Gene

Drugs & Compounds for OLA1 Gene

(4) Drugs for OLA1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for OLA1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with OLA1: view

Transcripts for OLA1 Gene

Unigene Clusters for OLA1 Gene

Obg-like ATPase 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OLA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLA1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - -
SP6: -
SP7: - -
SP8:
SP9:

Relevant External Links for OLA1 Gene

GeneLoc Exon Structure for
OLA1
ECgene alternative splicing isoforms for
OLA1

Expression for OLA1 Gene

mRNA expression in normal human tissues for OLA1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OLA1 Gene



Protein tissue co-expression partners for OLA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OLA1 Gene:

OLA1

SOURCE GeneReport for Unigene cluster for OLA1 Gene:

Hs.157351

mRNA Expression by UniProt/SwissProt for OLA1 Gene:

Q9NTK5-OLA1_HUMAN
Tissue specificity: Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus.
genes like me logo Genes that share expression patterns with OLA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for OLA1 Gene

Orthologs for OLA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OLA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLA1 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia OLA1 34 35
  • 97.14 (n)
cow
(Bos Taurus)
Mammalia OLA1 34 35
  • 96.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OLA1 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ola1 34 16 35
  • 93.43 (n)
rat
(Rattus norvegicus)
Mammalia Ola1 34
  • 92.93 (n)
oppossum
(Monodelphis domestica)
Mammalia OLA1 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLA1 34 35
  • 86.2 (n)
lizard
(Anolis carolinensis)
Reptilia OLA1 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ola1 34
  • 80.98 (n)
Str.9014 34
African clawed frog
(Xenopus laevis)
Amphibia MGC54033 34
zebrafish
(Danio rerio)
Actinopterygii ola1 34 35
  • 76.18 (n)
wufc66b09 34
fruit fly
(Drosophila melanogaster)
Insecta CG1354 34 35
  • 64.6 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000672 34
  • 64.08 (n)
worm
(Caenorhabditis elegans)
Secernentea ola-1 35
  • 68 (a)
OneToOne
tag-210 34
  • 63.27 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLA1 34 35 37
  • 58.64 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03608g 34
  • 57.59 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL192W 34
  • 54.19 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G30580 34
  • 62.41 (n)
soybean
(Glycine max)
eudicotyledons Gma.2708 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.724 34
rice
(Oryza sativa)
Liliopsida Os08g0199300 34
  • 61.48 (n)
Os.9634 34
barley
(Hordeum vulgare)
Liliopsida Hv.3018 34
wheat
(Triticum aestivum)
Liliopsida Ta.2982 34
corn
(Zea mays)
Liliopsida Zm.968 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5782 35
  • 71 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC27E2.03c 34
  • 58.14 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02044 34
  • 55.58 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3463 34
Species where no ortholog for OLA1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for OLA1 Gene

ENSEMBL:
Gene Tree for OLA1 (if available)
TreeFam:
Gene Tree for OLA1 (if available)

Paralogs for OLA1 Gene

(1) SIMAP similar genes for OLA1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OLA1: view

No data available for Paralogs for OLA1 Gene

Variants for OLA1 Gene

Sequence variations from dbSNP and Humsavar for OLA1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_036613 A breast cancer sample
rs193920787 Uncertain significance 174,082,006(-) TTCCT(G/T)TTAGT intron-variant, reference, missense
rs10048760 -- 174,113,248(+) TCAAA(G/T)AATTA intron-variant
rs10167547 -- 174,170,822(+) ttgcc(C/T)gagcc intron-variant
rs10172872 -- 174,163,711(+) aaata(A/T)atata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLA1 Gene

Variant ID Type Subtype PubMed ID
dgv2096n106 CNV deletion 24896259
esv2721155 CNV deletion 23290073
esv3438023 CNV insertion 20981092
esv3560566 CNV deletion 23714750
esv3593399 CNV gain 21293372
esv3593400 CNV loss 21293372
esv3866 CNV loss 18987735
esv5452 CNV loss 19470904
esv991222 CNV deletion 20482838
nsv1071639 CNV deletion 25765185
nsv1129210 CNV insertion 24896259
nsv3040 CNV deletion 18451855
nsv477550 CNV novel sequence insertion 20440878
nsv954712 CNV deletion 24416366

Variation tolerance for OLA1 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLA1 Gene

Disorders for OLA1 Gene

Relevant External Links for OLA1

Genetic Association Database (GAD)
OLA1
Human Genome Epidemiology (HuGE) Navigator
OLA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLA1

No disorders were found for OLA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLA1 Gene

Publications for OLA1 Gene

  1. Human OLA1 defines an ATPase subfamily in the Obg family of GTP- binding proteins. (PMID: 17430889) Koller-Eichhorn R. … Kambach C. (J. Biol. Chem. 2007) 2 3 4 64
  2. Regulation of cell-matrix adhesion by OLA1, the Obg-like ATPase 1. (PMID: 24486488) Jeyabal P.V. … Shi Z.Z. (Biochem. Biophys. Res. Commun. 2014) 2 3 64
  3. DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies. (PMID: 20053727) Sun H. … Huang Y. (Mol. Cancer Res. 2010) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for OLA1 Gene

Sources for OLA1 Gene

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