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Aliases for OLA1 Gene

Aliases for OLA1 Gene

  • Obg-Like ATPase 1 2 3
  • GTP-Binding Protein 9 (Putative) 2 3
  • GTPBP9 3 4
  • GTBP9 3 6
  • DOC45 3 4
  • DNA Damage-Regulated Overexpressed In Cancer 45 Protein 3
  • DNA Damage-Regulated Overexpressed In Cancer 45 4
  • Homologous Yeast-44.2 Protein 3
  • GTP-Binding Protein PTD004 3
  • GTP-Binding Protein 9 4
  • EC 3.6.3 63
  • PTD004 3
  • GBP45 3

External Ids for OLA1 Gene

Previous HGNC Symbols for OLA1 Gene

  • GTPBP9

Previous GeneCards Identifiers for OLA1 Gene

  • GC02M174646
  • GC02M174937
  • GC02M166816

Summaries for OLA1 Gene

GeneCards Summary for OLA1 Gene

OLA1 (Obg-Like ATPase 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding and hydrolase activity.

UniProtKB/Swiss-Prot for OLA1 Gene

  • Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP

Gene Wiki entry for OLA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLA1 Gene

Genomics for OLA1 Gene

Regulatory Elements for OLA1 Gene

Genomic Location for OLA1 Gene

Start:
174,072,447 bp from pter
End:
174,248,698 bp from pter
Size:
176,252 bases
Orientation:
Minus strand

Genomic View for OLA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLA1 Gene

Proteins for OLA1 Gene

  • Protein details for OLA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTK5-OLA1_HUMAN
    Recommended name:
    Obg-like ATPase 1
    Protein Accession:
    Q9NTK5
    Secondary Accessions:
    • D7EHM2
    • Q5BJD7
    • Q8NCI8
    • Q96CU1
    • Q96SV2
    • Q9P1D3
    • Q9UNY9
    • Q9Y6G4

    Protein attributes for OLA1 Gene

    Size:
    396 amino acids
    Molecular mass:
    44744 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for OLA1 Gene

    Alternative splice isoforms for OLA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLA1 Gene

Proteomics data for OLA1 Gene at MOPED

Post-translational modifications for OLA1 Gene

  • Ubiquitination at Lys83, Lys190, and Lys281
  • Modification sites at PhosphoSitePlus

Other Protein References for OLA1 Gene

Domains for OLA1 Gene

Suggested Antigen Peptide Sequences for OLA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NTK5

UniProtKB/Swiss-Prot:

OLA1_HUMAN :
  • Q9NTK5
Domain:
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
genes like me logo Genes that share domains with OLA1: view

No data available for Gene Families for OLA1 Gene

Function for OLA1 Gene

Molecular function for OLA1 Gene

UniProtKB/Swiss-Prot Function: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP
UniProtKB/Swiss-Prot Induction: Strongly down-regulated by DNA damage-inducing agents.

Enzyme Numbers (IUBMB) for OLA1 Gene

Gene Ontology (GO) - Molecular Function for OLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0005524 ATP binding IDA 17430889
GO:0005525 GTP binding IEA --
GO:0015093 ferrous iron transmembrane transporter activity --
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with OLA1: view

Animal Model Products

CRISPR Products

miRNA for OLA1 Gene

miRTarBase miRNAs that target OLA1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLA1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OLA1 Gene

Localization for OLA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLA1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLA1 Gene COMPARTMENTS Subcellular localization image for OLA1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for OLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OLA1: view

Pathways for OLA1 Gene

SuperPathways for OLA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0008152 metabolic process IEA --
GO:0015684 ferrous iron transport --
genes like me logo Genes that share ontologies with OLA1: view

No data available for Pathways by source for OLA1 Gene

Compounds for OLA1 Gene

(1) HMDB Compounds for OLA1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with OLA1: view

Transcripts for OLA1 Gene

Unigene Clusters for OLA1 Gene

Obg-like ATPase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLA1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - -
SP6: -
SP7: - -
SP8:
SP9:

Relevant External Links for OLA1 Gene

GeneLoc Exon Structure for
OLA1
ECgene alternative splicing isoforms for
OLA1

Expression for OLA1 Gene

mRNA expression in normal human tissues for OLA1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OLA1 Gene

SOURCE GeneReport for Unigene cluster for OLA1 Gene Hs.157351

mRNA Expression by UniProt/SwissProt for OLA1 Gene

Q9NTK5-OLA1_HUMAN
Tissue specificity: Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus
genes like me logo Genes that share expressions with OLA1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for OLA1 Gene

Orthologs for OLA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OLA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLA1 35
  • 100 (n)
  • 100 (a)
OLA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OLA1 35
  • 96.46 (n)
  • 99.24 (a)
OLA1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLA1 35
  • 97.14 (n)
  • 100 (a)
OLA1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ola1 35
  • 93.43 (n)
  • 99.49 (a)
Ola1 16
Ola1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLA1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLA1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ola1 35
  • 92.93 (n)
  • 98.23 (a)
chicken
(Gallus gallus)
Aves OLA1 35
  • 86.2 (n)
  • 91.16 (a)
OLA1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLA1 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC54033 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ola1 35
  • 80.98 (n)
  • 85.86 (a)
Str.9014 35
zebrafish
(Danio rerio)
Actinopterygii ola1 35
  • 76.18 (n)
  • 87.37 (a)
ola1 36
  • 87 (a)
OneToOne
wufc66b09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000672 35
  • 64.08 (n)
  • 73.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1354 35
  • 64.6 (n)
  • 74.16 (a)
CG1354 36
  • 73 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ola-1 36
  • 68 (a)
OneToOne
tag-210 35
  • 63.27 (n)
  • 68.19 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL192W 35
  • 54.19 (n)
  • 54.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLA1 35
  • 58.64 (n)
  • 55.24 (a)
OLA1 36
  • 53 (a)
OneToOne
OLA1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03608g 35
  • 57.59 (n)
  • 54.71 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.724 35
soybean
(Glycine max)
eudicotyledons Gma.2708 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G30580 35
  • 62.41 (n)
  • 62.76 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3018 35
corn
(Zea mays)
Liliopsida Zm.968 35
rice
(Oryza sativa)
Liliopsida Os.9634 35
Os08g0199300 35
  • 61.48 (n)
  • 62.5 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2982 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02044 35
  • 55.58 (n)
  • 53.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC27E2.03c 35
  • 58.14 (n)
  • 52.74 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3463 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5782 36
  • 71 (a)
OneToOne
Species with no ortholog for OLA1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for OLA1 Gene

ENSEMBL:
Gene Tree for OLA1 (if available)
TreeFam:
Gene Tree for OLA1 (if available)

Paralogs for OLA1 Gene

Selected SIMAP similar genes for OLA1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OLA1: view

No data available for Paralogs for OLA1 Gene

Variants for OLA1 Gene

Sequence variations from dbSNP and Humsavar for OLA1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1703 -- 174,181,590(+) ACTCA(C/T)TTGTT intron-variant
rs7274 -- 174,075,257(+) TGGAG(G/T)GGGGG utr-variant-3-prime
rs726622 -- 174,150,377(-) ACAAG(C/G)TCAGC intron-variant
rs726623 -- 174,150,373(-) GCTCA(C/G)CGGGC intron-variant
rs768371 -- 174,147,529(-) TATGT(G/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLA1 Gene

Variant ID Type Subtype PubMed ID
esv273879 CNV Insertion 20981092
nsv3040 CNV Loss 18451855
esv3866 CNV Deletion 18987735
esv991222 CNV Deletion 20482838
esv2721155 CNV Deletion 23290073
esv5452 CNV Loss 19470904

Relevant External Links for OLA1 Gene

HapMap Linkage Disequilibrium report
OLA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLA1 Gene

Disorders for OLA1 Gene

Relevant External Links for OLA1

Genetic Association Database (GAD)
OLA1
Human Genome Epidemiology (HuGE) Navigator
OLA1
genes like me logo Genes that share disorders with OLA1: view

No data available for UniProtKB/Swiss-Prot for OLA1 Gene

Publications for OLA1 Gene

  1. Human OLA1 defines an ATPase subfamily in the Obg family of GTP- binding proteins. (PMID: 17430889) Koller-Eichhorn R. … Kambach C. (J. Biol. Chem. 2007) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies. (PMID: 20053727) Sun H. … Huang Y. (Mol. Cancer Res. 2010) 3 4

Products for OLA1 Gene

  • Addgene plasmids for OLA1

Sources for OLA1 Gene

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