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Aliases for OIT3 Gene

Aliases for OIT3 Gene

  • Oncoprotein Induced Transcript 3 2 3 5
  • Liver-Specific Zona Pellucida Domain-Containing Protein 3 4
  • Liver-Specific ZP Domain-Containing Protein 2 3
  • LZP 3 4
  • Oncoprotein-Induced Transcript 3 Protein 3

External Ids for OIT3 Gene

Previous GeneCards Identifiers for OIT3 Gene

  • GC10P073998
  • GC10P074323
  • GC10P074654
  • GC10P068647

Summaries for OIT3 Gene

Entrez Gene Summary for OIT3 Gene

  • This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]

GeneCards Summary for OIT3 Gene

OIT3 (Oncoprotein Induced Transcript 3) is a Protein Coding gene. Diseases associated with OIT3 include Familial Juvenile Hyperuricaemic Nephropathy. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is UMOD.

UniProtKB/Swiss-Prot for OIT3 Gene

  • May be involved in hepatocellular function and development.

Additional gene information for OIT3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OIT3 Gene

Genomics for OIT3 Gene

GeneHancer (GH) Regulatory Elements for OIT3 Gene

Promoters and enhancers for OIT3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I072893 Promoter 0.7 EPDnew 550.8 +0.0 11 0.1 CEBPB ZBTB33 NR2F2 OIT3 NPM1P24
GH10I072951 Promoter/Enhancer 1.3 EPDnew ENCODE 10.4 +60.4 60366 4.2 ELF3 ATF1 FOXA2 ARID4B DMAP1 RAD21 YY1 ZNF335 SCRT2 ATF7 PLA2G12B CFAP70 NUDT13 OIT3 ECD DNAJB12 DNAJC9-AS1 NPM1P24
GH10I072782 Enhancer 1.1 FANTOM5 Ensembl ENCODE 9.8 -109.6 -109630 3.6 PKNOX1 KLF1 ZFHX2 POLR2A ZBTB48 EGR1 ZNF239 ZNF341 PRDM10 ZNF600 DNAJB12 OIT3 ENSG00000226163 ENSG00000272627 MCU
GH10I071919 Enhancer 1.1 Ensembl ENCODE 9.3 -972.1 -972123 4.3 HDGF PKNOX1 ATF1 ZNF766 REST TSHZ1 ZNF592 MBD2 ATF4 SMARCA4 OIT3 VSIR PSAP GC10M071945 ENSG00000230526
GH10I072845 Enhancer 0.8 Ensembl ENCODE 11 -47.2 -47153 1.2 SP1 JUND POLR3A JUN CEBPB FOSL2 FOS ZBTB33 EP300 RFX5 DNAJC9 MCU OIT3 RNU6-805P ENSG00000226163 RPL26P6 ZSWIM8 ENSG00000272627
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OIT3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OIT3 gene promoter:

Genomic Locations for OIT3 Gene

Genomic Locations for OIT3 Gene
39,481 bases
Plus strand

Genomic View for OIT3 Gene

Genes around OIT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OIT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OIT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OIT3 Gene

Proteins for OIT3 Gene

  • Protein details for OIT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oncoprotein-induced transcript 3 protein
    Protein Accession:
    Secondary Accessions:
    • A0AVP3
    • Q8N1M8

    Protein attributes for OIT3 Gene

    545 amino acids
    Molecular mass:
    60022 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OIT3 Gene


neXtProt entry for OIT3 Gene

Post-translational modifications for OIT3 Gene

  • Glycosylation at Asn89, Asn116, Asn291, and isoforms=2299

Other Protein References for OIT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OIT3 Gene

Domains & Families for OIT3 Gene

Gene Families for OIT3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for OIT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OIT3: view

No data available for UniProtKB/Swiss-Prot for OIT3 Gene

Function for OIT3 Gene

Molecular function for OIT3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in hepatocellular function and development.

Gene Ontology (GO) - Molecular Function for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with OIT3: view
genes like me logo Genes that share phenotypes with OIT3: view

Animal Models for OIT3 Gene

MGI Knock Outs for OIT3:

Animal Model Products

CRISPR Products

miRNA for OIT3 Gene

miRTarBase miRNAs that target OIT3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OIT3 Gene

Localization for OIT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OIT3 Gene

Nucleus envelope. Note=Can be secreted into blood.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OIT3 gene
Compartment Confidence
extracellular 3
nucleus 3
plasma membrane 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
genes like me logo Genes that share ontologies with OIT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OIT3 Gene

Pathways & Interactions for OIT3 Gene

No Data Available

Interacting Proteins for OIT3 Gene

Selected Interacting proteins: Q8WWZ8-OIT3_HUMAN for OIT3 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903118 urate homeostasis IEA --
genes like me logo Genes that share ontologies with OIT3: view

No data available for Pathways by source and SIGNOR curated interactions for OIT3 Gene

Drugs & Compounds for OIT3 Gene

No Compound Related Data Available

Transcripts for OIT3 Gene

mRNA/cDNA for OIT3 Gene

Unigene Clusters for OIT3 Gene

Oncoprotein induced transcript 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OIT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP2: -

Relevant External Links for OIT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OIT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OIT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OIT3 Gene

This gene is overexpressed in Liver (x33.8) and Spleen (x10.6).

Protein differential expression in normal tissues from HIPED for OIT3 Gene

This gene is overexpressed in Serum (49.8) and Plasma (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OIT3 Gene

Protein tissue co-expression partners for OIT3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OIT3 Gene:


SOURCE GeneReport for Unigene cluster for OIT3 Gene:


mRNA Expression by UniProt/SwissProt for OIT3 Gene:

Tissue specificity: Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines.

Evidence on tissue expression from TISSUES for OIT3 Gene

  • Liver(4.4)
  • Lung(4)
genes like me logo Genes that share expression patterns with OIT3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OIT3 Gene

Orthologs for OIT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OIT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OIT3 33 34
  • 99.39 (n)
(Bos Taurus)
Mammalia -- 34
  • 93 (a)
OIT3 33
  • 90.27 (n)
-- 34
  • 56 (a)
(Canis familiaris)
Mammalia OIT3 33 34
  • 91.01 (n)
(Rattus norvegicus)
Mammalia Oit3 33
  • 86.61 (n)
(Mus musculus)
Mammalia Oit3 33 16 34
  • 85.63 (n)
(Ornithorhynchus anatinus)
Mammalia OIT3 34
  • 84 (a)
(Monodelphis domestica)
Mammalia OIT3 34
  • 72 (a)
(Gallus gallus)
Aves OIT3 33 34
  • 75.15 (n)
(Anolis carolinensis)
Reptilia OIT3 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia oit3 33
  • 71.07 (n)
(Danio rerio)
Actinopterygii LOC100535938 33
  • 63.54 (n)
CU856520.1 34
  • 63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
-- 34
  • 18 (a)
-- 34
  • 17 (a)
CSA.3943 34
  • 16 (a)
-- 34
  • 12 (a)
Species where no ortholog for OIT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OIT3 Gene

Gene Tree for OIT3 (if available)
Gene Tree for OIT3 (if available)

Paralogs for OIT3 Gene

Paralogs for OIT3 Gene

genes like me logo Genes that share paralogs with OIT3: view

Variants for OIT3 Gene

Sequence variations from dbSNP and Humsavar for OIT3 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs145480078 uncertain-significance, Malignant tumor of prostate 72,932,484(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000054734 -- 72,913,081(+) C/T intron_variant
rs1000089075 -- 72,932,000(+) C/T intron_variant
rs1000212614 -- 72,928,034(+) A/G intron_variant
rs1000314997 -- 72,905,955(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OIT3 Gene

Variant ID Type Subtype PubMed ID
nsv528473 CNV gain 19592680
nsv948063 CNV duplication 23825009

Variation tolerance for OIT3 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OIT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OIT3 Gene

Disorders for OIT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OIT3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial juvenile hyperuricaemic nephropathy
  • fjhn
- elite association - COSMIC cancer census association via MalaCards
Search OIT3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OIT3

genes like me logo Genes that share disorders with OIT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OIT3 Gene

Publications for OIT3 Gene

  1. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. (PMID: 12939600) Xu ZG … Han ZG (Hepatology (Baltimore, Md.) 2003) 2 3 4 22 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (PMID: 15589826) Yang H … Guo J (FEBS letters 2004) 3 22 58
  5. Loss of heterozygosity at the calcium regulation gene locus on chromosome 10q in human pancreatic cancer. (PMID: 25824785) Long J … Ge CL (Asian Pacific journal of cancer prevention : APJCP 2015) 3 58

Products for OIT3 Gene

Sources for OIT3 Gene

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