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OIT3 Gene

protein-coding GIFtS: 50

GC10P074323

oncoprotein induced transcript 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ39116 ^¹, ²
LZP ^¹, ², ³, ⁵
OTTHUMP00000019791 ^²

Descriptions
Liver-specific zona pellucida domain-containing protein ^³
liver-specific ZP domain-containing protein ^²
oncoprotein induced transcript 3 ^²
oncoprotein-induced transcript 3 ^²

External Ids
HGNC: 29953¹
Entrez Gene: 170392²
UniProtKB: Q8WWZ8³
Ensembl: ENSG00000138315⁷

Search outside databases for aliases for OIT3 gene

Previous GC identifer: GC10P073998

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8

Function: May be involved in hepatocellular function and development

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OIT3 gene

Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.2-q22.3

OIT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P074323: (about GC identifiers)

Start:	74,323,345 bp from pter
End:	74,362,793 bp from pter
Size:	39,449 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8 (See protein sequence)

Recommended Name: Oncoprotein-induced transcript 3 protein precursor

Size: 545 amino acids; 60022 Da

Subcellular location: Nucleus envelope. Note=Can be secreted into blood

Secondary accessions: A0AVP3 Q8N1M8

Alternative splicing: 2 isoforms: Q8WWZ8-1 Q8WWZ8-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_689848.1

ENSEMBL proteins:

ENSP00000333900

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (OIT3)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005635	nuclear envelope	IEA	--

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Antibodies for OIT3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (OIT3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OIT3

Assays for OIT3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8WWZ8

ProtoNet protein and cluster: Q8WWZ8

3 Blocks protein families:

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB001507 Endoglin/CD105 antigen

IPB001881 EGF-like calcium-binding

UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 ZP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OIT3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OIT3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152635

Applied Biosystems Silencer® siRNAs for OIT3

Sigma-Aldrich siRNA for OIT3

Sigma-Aldrich shRNA for OIT3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_152635
Myc/DDK tagged cDNA clone in CMV expression vector: NM_152635
untagged cDNA clone in CMV expression vector: NM_152635

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_152635

UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8

Function: May be involved in hepatocellular function and development

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OIT3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OIT3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OIT3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152635

Sigma-Aldrich siRNA for OIT3

Sigma-Aldrich shRNA for OIT3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_152635

REFSEQ mRNAs for OIT3 gene:

NM_152635.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_152635

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152635
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_152635
                                 untagged cDNA clone in CMV expression vector: NM_152635

Additional cDNA sequence:

AF075085.1 AK096435.1 AY013707.2 AY358339.1 BC126440.1

4 DOTS entries:

DT.95128719 DT.100746234 DT.113412 DT.306879

24/52 AceView cDNA sequences (see all 52 ):

AV695874 AI287565 AV651238 BF592796 BX498775 AY358339 AA340890 AV651182

AF075085 AV651191 NM_152635 AA430114 AK096435 T40097 AV651225 AW590571

AY013707 BX279604 AV650082 AV651252 H94467 AV651977 AA693997 H58673

highest scoring ESTs for OIT3:

AA702703 AK096435 AY013707 AY358339 AA430114 AA677443 AA693997 AF075085 AI096996 AI287565

Unigene Cluster for OIT3:

Oncoprotein induced transcript 3

Hs.8366 [show with all ESTs]

Unigene Representative Sequence: AK096435

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for OIT3

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9
SP1:
SP2:																	-

About this scheme

ECgene alternative splicing isoforms for OIT3

1 Ensembl transcript including schematic representation:

ENST00000334011

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OIT3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OIT3

¹ / ² / ³

3 probe-sets matching OIT3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
62948_at²^{, 3}	U95-C	1	1.00	1.00	1.00	1.00	AA702703	0.80	1.00	0.91	1
230478_at²^{, 3}	U133-B	1	1.00	1.00	--	--	R85632	0.60	1.00	0.82	1
230478_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks OIT3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGATCTTCCC

SOURCE GeneReport for Unigene cluster: Hs.8366
UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8
Tissue specificity: Liver-specific. Expressed only in the hepatocytes. Down-regulated in
hepatocellular carcinoma (HCC) and HCC cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OIT3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OIT3¹	--	oncoprotein induced transcript 3	91.01(n) 93.58(a)	489044 XM_546162.2 XP_546162.2
chimpanzee (Pan troglodytes)	OIT3¹	--	oncoprotein induced transcript 3	99.39(n) 99.27(a)	736222 XM_001138842.1 XP_001138842.1
cow (Bos taurus)	OIT3¹	--	oncoprotein induced transcript 3	88.81(n) 91.01(a)	510915 NM_001046064.1 NP_001039529.1
rat (Rattus norvegicus)	Oit3¹	--	oncoprotein induced transcript 3	86.61(n) 91.19(a)	294559 NM_001001507.1 NP_001001507.1
mouse (Mus musculus)	Oit3^{1, 5}	10⁵	oncoprotein induced transcript 3^{1, 5}	85.63(n)¹ 89.72(a)¹	18302¹ NM_010959.2¹ NP_035089.1¹ AF356506⁵ AF517106⁵ (see all 14)

About this table Species with no ortholog for OIT3

ENSEMBL Gene Tree for OIT3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OIT3 gene

GP2² UMOD²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/133 NCBI SNPs in OIT3 are shown (see all 133 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1316943^1,2	A,C,H	74321908(+)	`AAATTT/CTTCAT`	1	--	ng5¹		4	EU EA WA	414
	rs11816594^1,2	C,F,H	74322877(+)	`GTAAAG/AACAAT`	1	--	ng5¹ tfbs³		8	EU EA WA NA	736
	rs7083168^1,2	C,F,H	74363276(+)	`CCTGTG/TATTTG`	1	--	ng3¹		4	EU EA WA	414
	rs35089256^1,2	C,F	74341522(+)	`GCCACT/CCTTGC`	1	P/S	mis¹		5	NA EU EA WA	488
	rs12260002^1,2	C,F,H	74354307(+)	`GAGCCC/TGTGGT`	1	P/P	syn¹ ese³		4	EU EA WA	416
	rs7911269^1,2	A,C,F,H	74330805(+)	`ctagcT/Ctgggt`	1	--	int¹		2	EA	178
	rs7921735^1,2	A,C,F,H	74353931(+)	`AGGGGG/AAAAAA`	1	--	int¹ trp³		3	EU EA	288
--	rs7090452^1,2	A,C,F,H	74347006(+)	`tgcctG/Ctgtct`	1	--	int¹		3	EA WA	298
	rs11000444^1,2	A,C,F,H	74338519(+)	`TAAAAA/CCTAAT`	1	--	int¹		7	EU EA WA NA	520
	rs11000445^1,2	A,C,F,H	74342405(+)	`tattTT/CTGATT`	1	--	int¹		16	EU EA WA NA	1470

About this table

HapMap Linkage Disequilibrium images for OIT3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609330

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for OIT3 gene:

A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. (PubMed id 12939600)^{1, 2, 3, 4} Xu Z.G....Han Z.G. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{2, 3, 4} Clark H.F....Gray A. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (PubMed id 15589826)^{1, 3} Yang H....Guo J. (2004)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)⁴ Chen R.... Zou H. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory protein. (PubMed id 15346761)¹ Xu Z.G....Han Z.G. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 170392	HGNC: 29953	AceView: OIT3	Ensembl:ENSG00000138315	euGenes: HUgn170392
ECgene: OIT3	H-InvDB: OIT3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for OIT3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OIT3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OIT3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OIT3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OIT3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for OIT3

Search Tocris compounds for OIT3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for OIT3

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OIT3 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for OIT3

Summaries
for OIT3

Genomic Location
for OIT3

Proteins
for OIT3

Protein Domains/
Families
for OIT3

Gene Function
for OIT3

Pathways & Interactions
for OIT3

Drugs & Compounds
for OIT3

Transcripts
for OIT3

Expression
for OIT3

Orthologs
for OIT3

Paralogs
for OIT3

SNPs/Variants
for OIT3

Disorders & Mutations
for OIT3

Medical News
for OIT3

Publications
for OIT3

Search for OIT3

Genome Databases showing OIT3

Other Databases showing OIT3

Specialized Databases showing OIT3

Licensable Technologies
for OIT3

Services
for OIT3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OIT3 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor OIT3

Summariesfor OIT3

Genomic Locationfor OIT3

Proteinsfor OIT3

Protein Domains/Familiesfor OIT3

Gene Functionfor OIT3

Pathways & Interactionsfor OIT3

Drugs & Compoundsfor OIT3

Transcriptsfor OIT3

Expression for OIT3

Orthologsfor OIT3

Paralogsfor OIT3

SNPs/Variantsfor OIT3

Disorders & Mutationsfor OIT3

Medical Newsfor OIT3

Publicationsfor OIT3

Search for OIT3

Genome Databases showing OIT3

Other Databases showing OIT3

Specialized Databases showing OIT3

Licensable Technologiesfor OIT3

Servicesfor OIT3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OIT3

Summaries
for OIT3

Genomic Location
for OIT3

Proteins
for OIT3

Protein Domains/
Families
for OIT3

Gene Function
for OIT3

Pathways & Interactions
for OIT3

Drugs & Compounds
for OIT3

Transcripts
for OIT3

Expression
for OIT3

Orthologs
for OIT3

Paralogs
for OIT3

SNPs/Variants
for OIT3

Disorders & Mutations
for OIT3

Medical News
for OIT3

Publications
for OIT3

Licensable Technologies
for OIT3

Services
for OIT3