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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OIT3 Gene

protein-coding   GIFtS: 47
GCID: GC10P074654

Oncoprotein Induced Transcript 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Oncoprotein Induced Transcript 31 2
LZP2 3 5
Liver-Specific Zona Pellucida Domain-Containing Protein2 3
Liver-Specific ZP Domain-Containing Protein2
Oncoprotein-Induced Transcript 3 Protein2

External Ids:    HGNC: 299531   Entrez Gene: 1703922   Ensembl: ENSG000001383157   OMIM: 6093305   UniProtKB: Q8WWZ83   

Export aliases for OIT3 gene to outside databases

Previous GC identifers: GC10P073998 GC10P074323 GC10P068647


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OIT3 Gene: 
OIT3 (oncoprotein induced transcript 3) is a protein-coding gene. Diseases associated with OIT3 include familial juvenile hyperuricaemic nephropathy, and hepatocellular carcinoma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is GP2.

UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8
Function: May be involved in hepatocellular function and development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OIT3 gene promoter:
         HOXA9   HOXA9B   STAT1   p300   STAT1beta   LCR-F1   STAT1alpha   Meis-1b   STAT3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOIT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for OIT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OIT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.2-q22.3

OIT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OIT3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P074654:  view genomic region     (about GC identifiers)

Start:
74,653,339 bp from pter      End:
74,692,791 bp from pter
Size:
39,453 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8 (See protein sequence)
Recommended Name: Oncoprotein-induced transcript 3 protein precursor  
Size: 545 amino acids; 60022 Da
Subcellular location: Nucleus envelope. Note=Can be secreted into blood
Secondary accessions: A0AVP3 Q8N1M8
Alternative splicing: 2 isoforms:  Q8WWZ8-1   Q8WWZ8-2   

Explore the universe of human proteins at neXtProt for OIT3: NX_Q8WWZ8

Explore proteomics data for OIT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WWZ8

  • OIT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OIT3 Protein Expression
    REFSEQ proteins: NP_689848.1  
    ENSEMBL proteins: 
     ENSP00000333900  

    Human Recombinant Protein Products for OIT3: 
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    Cloud-Clone Corp. Proteins for OIT3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--

    OIT3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR001881 EGF-like_Ca-bd
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry Q8WWZ8

    ProtoNet protein and cluster: Q8WWZ8

    3 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001507 Endoglin/CD105 antigen
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 ZP domain


    OIT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OIT3_HUMAN, Q8WWZ8
    Function: May be involved in hepatocellular function and development

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    OIT3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Oit3):
     homeostasis/metabolism  renal/urinary system 

    OIT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for OIT3: Oit3tm1Zgh Oit3tm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OIT3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OIT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OIT3 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate OIT3:
    hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidOIT3 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for OIT3
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OIT3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OIT3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OIT3

    Search CenterWatch for drugs/clinical trials and news about OIT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OIT3 gene: 
    NM_152635.1  

    Unigene Cluster for OIT3:

    Oncoprotein induced transcript 3
    Hs.8366  [show with all ESTs]
    Unigene Representative Sequence: AK096435
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334011(uc001jte.1 uc009xqs.1)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate OIT3:
    hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidOIT3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OIT3

    Additional mRNA sequence: 

    AF075085.1 AK096435.1 AY013707.2 AY358339.1 BC126440.1 

    3 DOTS entries:

    DT.95128719  DT.100746234  DT.113412 

    24/52 AceView cDNA sequences (see all 52):

    BX279604 AA340890 AV695874 BX498775 AW590571 NM_152635 AV651225 AI287565 
    AY013707 AV651182 BF592796 AY358339 AF075085 AV651238 AK096435 AV651191 
    AA430114 T40097 AA677443 AA693997 AV651977 AV650082 AV651252 H94467 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for OIT3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                  
    SP2:                                                  -               


    ECgene alternative splicing isoforms for OIT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OIT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATCTTCCC
    OIT3 Expression
    About this image


    See OIT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OIT3

    SOURCE GeneReport for Unigene cluster: Hs.8366

    UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8
    Tissue specificity: Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma
    (HCC) and HCC cell lines

        SABiosciences Custom PCR Arrays for OIT3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OIT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OIT3 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oit31 , 5 oncoprotein induced transcript 31, 5 85.63(n)1
    89.72(a)1
      10 (29.54 cM)5
    183021  NM_010959.21  NP_035089.11 
     594229585 
    chicken
    (Gallus gallus)
    Aves OIT31 oncoprotein induced transcript 3 75.54(n)
    81.56(a)
      423706  XM_421585.3  XP_421585.2 
    lizard
    (Anolis carolinensis)
    Reptilia OIT36
    oncoprotein induced transcript 3
    76(a)
    1 ↔ 1
    3(52414588-52470363)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005359381 oncoprotein-induced transcript 3 protein-like 64.48(n)
    65.44(a)
      100535938  XM_003199689.1  XP_003199737.1 


    ENSEMBL Gene Tree for OIT3 (if available)
    TreeFam Gene Tree for OIT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OIT3 gene
    GP22  UMOD2  

    OIT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/778 SNPs in OIT3 are shown (see all 778)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008941941,2
    C--74651476(+) TTTGC-/TTTTTA 1 -- us2k10--------
    rs1158567261,2
    C,F--74651653(+) GTTTGG/AATCCT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs776100071,2
    C,F--74651877(+) CTTTAT/CACTTT 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs13169431,2
    C,A,H--74651902(+) AAATTT/CTTCAT 1 -- us2k15Minor allele frequency- C:0.00NS EA NA 416
    rs1410488291,2
    C--74651930(+) GAAAGA/GGCAGG 1 -- us2k10--------
    rs1830073891,2
    --74651934(+) GAGCAA/GGTCAA 1 -- us2k10--------
    rs1448623641,2
    --74652020(+) GCTATC/TTGGTG 1 -- us2k10--------
    rs1886434621,2
    --74652115(+) TGAAGC/TCCTCA 1 -- us2k10--------
    rs1929728991,2
    --74652152(+) TGGGGG/TATTGT 1 -- us2k10--------
    rs1387381441,2
    C--74652251(+) ATAAGC/TTAATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OIT3 (74653339 - 74692791 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OIT3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528473CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609330    OMIM disorders: --

    2 diseases for OIT3:    About MalaCards
    familial juvenile hyperuricaemic nephropathy    hepatocellular carcinoma


    OIT3 for disorders           About GeneDecksing


    Export disorders for OIT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OIT3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OIT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. (PubMed id 12939600)1, 2, 3, 9 Xu Z.-G.... Han Z.-G. (2003)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (PubMed id 15589826)1, 9 Yang H....Guo J. (2004)
    5. Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules. (PubMed id 18830570)1 Shen H.L....Han Z.G. (2009)
    6. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory protein. (PubMed id 15346761)9 Xu Z.G....Han Z.G. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 170392 HGNC: 29953 AceView: OIT3 Ensembl:ENSG00000138315 euGenes: HUgn170392
    ECgene: OIT3 H-InvDB: OIT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OIT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OIT3 gene:
    Search GeneIP for patents involving OIT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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