Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



OIT3 Gene

protein-coding   GIFtS: 47
GCID: GC10P074654

Oncoprotein Induced Transcript 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Oncoprotein Induced Transcript 31 2
LZP2 3 5
Liver-Specific Zona Pellucida Domain-Containing Protein2 3
Liver-Specific ZP Domain-Containing Protein2
Oncoprotein-Induced Transcript 3 Protein2

External Ids:    HGNC: 299531   Entrez Gene: 1703922   Ensembl: ENSG000001383157   OMIM: 6093305   UniProtKB: Q8WWZ83   

Export aliases for OIT3 gene to outside databases

Previous GC identifers: GC10P073998 GC10P074323 GC10P068647


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for OIT3 Gene:
OIT3 (oncoprotein induced transcript 3) is a protein-coding gene. Diseases associated with OIT3 include familial juvenile hyperuricaemic nephropathy, and hepatocellular carcinoma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is GP2.

UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8
Function: May be involved in hepatocellular function and development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OIT3 gene promoter:
         HOXA9   HOXA9B   STAT1   p300   STAT1beta   LCR-F1   STAT1alpha   Meis-1b   STAT3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOIT3 promoter sequence
   Search Chromatin IP Primers for OIT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OIT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.2-q22.3

OIT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OIT3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P074654:  view genomic region     (about GC identifiers)

Start:
74,653,339 bp from pter      End:
74,692,791 bp from pter
Size:
39,453 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8 (See protein sequence)
Recommended Name: Oncoprotein-induced transcript 3 protein precursor  
Size: 545 amino acids; 60022 Da
Secondary accessions: A0AVP3 Q8N1M8
Alternative splicing: 2 isoforms:  Q8WWZ8-1   Q8WWZ8-2   

Explore the universe of human proteins at neXtProt for OIT3: NX_Q8WWZ8

Explore proteomics data for OIT3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn89, Asn116, Asn291, Asn299

  • See OIT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689848.1  
    ENSEMBL proteins: 
     ENSP00000333900  

    OIT3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for OIT3
    OriGene Protein Over-expression Lysate for OIT3
    OriGene MassSpec for OIT3
    OriGene Custom Protein Services for OIT3
    GenScript Custom Purified and Recombinant Proteins Services for OIT3
    Novus Biologicals OIT3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OIT3

    OIT3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for OIT3
    Novus Biologicals OIT3 Antibody
    Abcam antibodies for OIT3
    Cloud-Clone Corp. Antibodies for OIT3
    ThermoFisher Antibodies for OIT3
    LSBio Antibodies in human, mouse, rat for OIT3

    OIT3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OIT3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OIT3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OIT3
    Cloud-Clone Corp. CLIAs for OIT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR001881 EGF-like_Ca-bd_dom
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry Q8WWZ8

    ProtoNet protein and cluster: Q8WWZ8

    3 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001507 Endoglin/CD105 antigen
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 ZP domain


    OIT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OIT3_HUMAN, Q8WWZ8
    Function: May be involved in hepatocellular function and development

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    OIT3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Oit3):
     homeostasis/metabolism  renal/urinary system 

    OIT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for OIT3: Oit3tm1Zgh Oit3tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OIT3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OIT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OIT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OIT3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat OIT3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate OIT3:
    hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidOIT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OIT3
    Predesigned siRNA for gene silencing in human, mouse, rat OIT3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OIT3

    Clone
    Products:
         
    OriGene clones in human, mouse for OIT3 (see all 7)
    OriGene ORF clones in mouse, rat for OIT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OIT3 (NM_152635)
    Sino Biological Human cDNA Clone for OIT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OIT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OIT3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OIT3
    Browse ESI BIO Cell Lines and PureStem Progenitors for OIT3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OIT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    OIT3_HUMAN, Q8WWZ8: Nucleus envelope. Note=Can be secreted into blood
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular3
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--

    OIT3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OIT3
    Interactions:

        Search GeneGlobe Interaction Network for OIT3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OIT3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for OIT3 gene: 
    NM_152635.1  

    Unigene Cluster for OIT3:

    Oncoprotein induced transcript 3
    Hs.8366  [show with all ESTs]
    Unigene Representative Sequence: AK096435
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334011(uc001jte.1 uc009xqs.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OIT3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate OIT3:
    hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidOIT3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OIT3
    Predesigned siRNA for gene silencing in human, mouse, rat OIT3
    Clone
    Products:
         
    OriGene clones in human, mouse for OIT3 (see all 7)
    OriGene ORF clones in mouse, rat for OIT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OIT3 (NM_152635)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OIT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OIT3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OIT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OIT3
      QuantiTect SYBR Green Assays in human, mouse, rat OIT3
      QuantiFast Probe-based Assays in human, mouse, rat OIT3

    Additional mRNA sequence: 

    AF075085.1 AK096435.1 AY013707.2 AY358339.1 BC126440.1 

    3 DOTS entries:

    DT.95128719  DT.100746234  DT.113412 

    Selected AceView cDNA sequences (see all 52):

    AV651238 AV651182 BX498775 AA340890 AK096435 AI287565 AA430114 AY013707 
    AV651191 AW590571 BF592796 AV695874 BX279604 AF075085 NM_152635 T40097 
    AV651225 AY358339 H58673 T70583 AV650082 AV651977 AA677443 AA693997 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for OIT3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                  
    SP2:                                                  -               


    ECgene alternative splicing isoforms for OIT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    OIT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATCTTCCC
    OIT3 Expression
    About this image


    OIT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Liver (Hepatobiliary System)
     
     Spleen (Hematopoietic System)
    OIT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OIT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8366

    UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8
    Tissue specificity: Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma
    (HCC) and HCC cell lines

        Custom PCR Arrays for OIT3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OIT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OIT3
    QuantiTect SYBR Green Assays in human, mouse, rat OIT3
    QuantiFast Probe-based Assays in human, mouse, rat OIT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OIT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for OIT3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oit31 , 5 oncoprotein induced transcript 31, 5 85.63(n)1
    89.72(a)1
      10 (29.54 cM)5
    183021  NM_010959.21  NP_035089.11 
     594229585 
    chicken
    (Gallus gallus)
    Aves OIT31 oncoprotein induced transcript 3 75.15(n)
    80.81(a)
      423706  XM_421585.4  XP_421585.2 
    lizard
    (Anolis carolinensis)
    Reptilia OIT36
    oncoprotein induced transcript 3
    76(a)
    1 ↔ 1
    3(52414588-52470363)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia oit31 oncoprotein induced transcript 3 71.07(n)
    77.06(a)
      100492443  XM_002935968.2  XP_002936014.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005359381 oncoprotein-induced transcript 3 protein-like 63.54(n)
    64.35(a)
      100535938  XM_003199689.2  XP_003199737.2 


    ENSEMBL Gene Tree for OIT3 (if available)
    TreeFam Gene Tree for OIT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for OIT3 gene
    GP22  UMOD2  

    OIT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for OIT3 (see all 778)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008941941,2
    C--74651476(+) TTTGC-/TTTTTA 1 -- us2k10--------
    rs1158567261,2
    C,F--74651653(+) GTTTGG/AATCCT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs776100071,2
    C,F--74651877(+) CTTTAT/CACTTT 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs13169431,2
    C,A,H--74651902(+) AAATTT/CTTCAT 1 -- us2k15Minor allele frequency- C:0.00NS EA NA 416
    rs1410488291,2
    C--74651930(+) GAAAGA/GGCAGG 1 -- us2k10--------
    rs1830073891,2
    --74651934(+) GAGCAA/GGTCAA 1 -- us2k10--------
    rs1448623641,2
    --74652020(+) GCTATC/TTGGTG 1 -- us2k10--------
    rs1886434621,2
    --74652115(+) TGAAGC/TCCTCA 1 -- us2k10--------
    rs1929728991,2
    --74652152(+) TGGGGG/TATTGT 1 -- us2k10--------
    rs1387381441,2
    C--74652251(+) ATAAGC/TTAATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OIT3 (74653339 - 74692791 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OIT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528473CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OIT3
    DNA2.0 Custom Variant and Variant Library Synthesis for OIT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609330    OMIM disorders: --

    2 diseases for OIT3:    
    About MalaCards
    familial juvenile hyperuricaemic nephropathy    hepatocellular carcinoma


    OIT3 for disorders           About GeneDecksing


    Export disorders for OIT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for OIT3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OIT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. (PubMed id 12939600)1, 2, 3, 9 Xu Z.-G.... Han Z.-G. (Hepatology 2003)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (PubMed id 15589826)1, 9 Yang H....Guo J. (FEBS Lett. 2004)
    5. Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules. (PubMed id 18830570)1 Shen H.L....Han Z.G. (Mol. Cell. Biochem. 2009)
    6. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory protein. (PubMed id 15346761)9 Xu Z.G....Han Z.G. (DNA Seq. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 170392 HGNC: 29953 AceView: OIT3 Ensembl:ENSG00000138315 euGenes: HUgn170392
    ECgene: OIT3 H-InvDB: OIT3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for OIT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for OIT3 gene:
    Search GeneIP for patents involving OIT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OIT3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for OIT3  
     OriGene MassSpec something-or-other for OIT3   OriGene clones in human, mouse for OIT3  
     OriGene qSTAR qPCR primer pairs in human, mouse for OIT3   OriGene Purified Protein for OIT3  
     OriGene ORF clones in mouse, rat for OIT3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OIT3   OriGene Custom Protein Services for OIT3  

     
     
     Block miRNA regulation of human, mouse, rat OIT3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OIT3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OIT3 Predesigned siRNA for gene silencing in human, mouse, rat OIT3
     QuantiFast Probe-based Assays in human, mouse, rat OIT3 QuantiTect SYBR Green Assays in human, mouse, rat OIT3
     Custom PCR Arrays for OIT3 Search Chromatin IP Primers for OIT3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OIT3  Search GeneGlobe Interaction Network for OIT3
     Regulatory tfbs in OIT3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for OIT3 GenScript cDNA clones with any tag delivered in your preferred vector for OIT3
     GenScript Custom Assay Services for OIT3 GenScript Custom overexpressing Cell Line Services for OIT3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for OIT3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for OIT3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     OIT3 antibodies
     OIT3 lysates
     Antibodies for OIT3
     See all of Abcam's Antibodies, Kits and Proteins for OIT3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for OIT3
     Antibodies for OIT3
     ELISAs for OIT3
     CLIAs for OIT3



     Browse ESI BIO Cell Lines and PureStem Progenitors for OIT3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OIT3
     SwitchGear 3'UTR luciferase reporter plasmids for OIT3
     SwitchGear Promoter luciferase reporter plasmids for OIT3
     ThermoFisher Antibodies for OIT3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OIT3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OIT3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OIT3
     LSBio Antibodies in human, mouse, rat for OIT3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OIT3 gene at Home site.
    Version: 3.12.158 12 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4