OIT3 Gene
protein-coding GIFtS : 46
GCID: GC10 P074654
oncoprotein induced transcript 3
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Aliasesfor OIT3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Oncoprotein Induced Transcript 3 1 2 LZP1 2 3 5 Liver-Specific Zona Pellucida Domain-Containing Protein2 3 FLJ391161 Liver-Specific ZP Domain-Containing Protein2 Oncoprotein-Induced Transcript 3 Protein2
Export aliases for OIT3 gene to outside databases Previous GC identifers: GC10P073998 GC10P074323 GC10P068647
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Summariesfor OIT3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8 Function : May be involved in hepatocellular function and development
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Genomic Viewsfor OIT3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.1 NT_030059.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OIT3 gene promoter: HOXA9 HOXA9B STAT1 p300 STAT1beta LCR-F1 STAT1alpha Meis-1b STAT3 Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for OIT3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OIT3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.2-q22.3 OIT3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P074654: view genomic region
(about GC identifiers )
Start:
74,653,339 bp from pter
End:
74,692,791 bp from pter
Size:
39,453 bases
Orientation:
plus strand
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Proteinsfor OIT3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8 (See
protein sequence )Recommended Name: Oncoprotein-induced transcript 3 protein precursor Size : 545 amino acids; 60022 Da
Subcellular location : Nucleus envelope. Note=Can be secreted into blood
Secondary accessions : A0AVP3 Q8N1M8Alternative splicing : 2 isoforms : Q8WWZ8-1 Q8WWZ8-2 Explore the universe of human proteins at neXtProt for OIT3: NX_Q8WWZ8 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8WWZ8 OIT3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_689848.1 ENSEMBL proteins: ENSP00000333900 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005635 nuclear envelope
IEA --
OIT3 for ontologies About GeneDecksing OIT3 Antibody Products: Assay Products for OIT3:
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Protein
Domains / Familiesfor OIT3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
OIT3 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8WWZ8 ProtoNet protein and cluster: Q8WWZ8
3 Blocks protein families : IPB000152 Aspartic acid and asparagine hydroxylation site IPB001507 Endoglin/CD105 antigen IPB001881 EGF-like calcium-binding UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8 Similarity : Contains 1 EGF-like domainSimilarity : Contains 1 ZP domain
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Functionfor OIT3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8 Function : May be involved in hepatocellular function and development
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OIT3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OIT3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: OIT3 (NM_152635 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OIT3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OIT3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OIT3
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005509 calcium ion binding
IEA --
OIT3 for ontologies About GeneDecksing Animal Models: Mouse knock-outs for OIT3: Oit3 tm1Zgh Oit3 tm1Lex 2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Oit3) :
OIT3 for phenotypes About GeneDecksing
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Pathways & Interactionsfor OIT3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OIT3
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Drugs & Compoundsfor OIT3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for OIT3 Search CenterWatch for drugs/clinical trials and news about OIT3
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Transcriptsfor OIT3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for OIT3 gene: NM_152635.1 Unigene Cluster for OIT3:
Oncoprotein induced transcript 3 Hs.8366 [show with all ESTs ] Unigene Representative Sequence: AK096435 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000334011 (uc001jte.1 uc009xqs.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OIT3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OIT3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: OIT3 (NM_152635 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OIT3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OIT3
Additional cDNA sequence: AF075085.1 AK096435.1 AY013707.2 AY358339.1 BC126440.1
3 DOTS entries : DT.95128719 DT.100746234
DT.113412 24/52 AceView cDNA sequences (see all 52 ):
AV651238 AY358339 AK096435 AV695874 AV651191 AV651182 NM_152635 BX498775 AY013707 AW590571 AV651225 AA430114 AI287565 BF592796 AA340890 BX279604 AF075085 T40097 AV651977 H58673 T70583 AA693997 AA677443 AV651252 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for OIT3 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 SP1 :                       SP2 :                 -      
ECgene alternative splicing isoforms for OIT3
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Expression for OIT3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section OIT3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGATCTTCCC
About this image OIT3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See OIT3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OIT3 SOURCE GeneReport for Unigene cluster: Hs.8366 UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8 Tissue specificity : Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma (HCC)and HCC cell lines SABiosciences Custom PCR Arrays for OIT3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for OIT3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat OIT3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat OIT3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat OIT3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OIT3
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Orthologsfor OIT3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for OIT3 gene from 4/12 species (see all 12 ) About this table
ENSEMBL Gene Tree for OIT3 (if available)TreeFam Gene Tree for OIT3 (if available)
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Paralogsfor OIT3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for OIT3 gene UMODL1 2 GP2 2 UMOD 2
OIT3 for paralogs About GeneDecksing
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Genomic Variantsfor OIT3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 10 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for OIT3 (74653339 - 74692791 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for OIT3: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing OIT3
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Disorders
/ Diseasesfor OIT3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
OIT3 for disorders About GeneDecksing
OMIM gene information: 609330
OMIM disorders : --5 diseases for OIT3 : About MalaCards epilepsia partialis continua familial juvenile hyperuricaemic nephropathy nephropathy hepatocellular carcinoma carcinoma Export disorders for OIT3 gene to outside databases
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Publicationsfor OIT3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for OIT3 gene integrated from 9 sources : (articles sorted by number of sources associating them with OIT3) Utopia : connect your pdf to the dynamic world of online information
A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. (PubMed id 12939600) 1 , 2 , 3, 9 Xu Z.-G.... Han Z.-G. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 , 3 Clark H.F.... Gray A.M. (2003) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (PubMed id 15589826) 1 , 9 Yang H....Guo J. (2004) Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules. (PubMed id 18830570) 1 Shen H.L....Han Z.G. (2009) Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218) 2 Chen R.... Zou H. (2009) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory protein. (PubMed id 15346761) 9 Xu Z.G....Han Z.G. (2004)
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External Searches for OIT3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing OIT3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing OIT3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing OIT3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for OIT3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for OIT3 gene: Search GeneIP for patents involving OIT3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor OIT3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for OIT3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for OIT3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for OIT3 OriGene Protein Over-expression Lysate for OIT3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for OIT3 OriGene 3'-UTR Clone for OIT3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OIT3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OIT3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for OIT3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for OIT3 OriGene Custom Protein Services for OIT3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OIT3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing OIT3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OIT3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat OIT3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat OIT3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat OIT3
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OIT3
ThermoFisher Antibodies for OIT3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OIT3
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