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Aliases & Descriptions for OIT3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ39116 1, 2 | | LZP 1, 2, 3, 5 | | OTTHUMP00000019791 2 |
| | | Descriptions |
|---|
| Liver-specific zona pellucida domain-containing protein 3 | | liver-specific ZP domain-containing protein 2 | | oncoprotein induced transcript 3 2 | | oncoprotein-induced transcript 3 2 |
|
| | Search outside databases for aliases for OIT3 genePrevious GC identifer: GC10P073998 |
Summaries for OIT3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8Function: May be involved in hepatocellular function and development |
Genomic Location for OIT3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OIT3 gene 
Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.2-q22.3OIT3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P074323:
(about GC identifiers)
Start:
|
74,323,345 bp from pter |
End:
|
74,362,793 bp from pter |
Size:
|
39,449 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_008583.16
| Proteins for OIT3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8 (See
protein sequence)Recommended Name: Oncoprotein-induced transcript 3 protein precursor Size: 545 amino acids; 60022 Da
Subcellular location: Nucleus envelope. Note=Can be secreted into blood
Secondary accessions: A0AVP3 Q8N1M8Alternative splicing: 2 isoforms: Q8WWZ8-1 Q8WWZ8-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_689848.1
ENSEMBL proteins: ENSP00000333900
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for OIT3: Assays for OIT3: | Protein
Domains/ Families for OIT3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8WWZ8
ProtoNet protein and cluster: Q8WWZ8 3 Blocks protein families: IPB000152 Aspartic acid and asparagine hydroxylation site IPB001507 Endoglin/CD105 antigen IPB001881 EGF-like calcium-binding
UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8Similarity: Contains 1 EGF-like domainSimilarity: Contains 1 ZP domain | Gene Function for OIT3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152635
Applied Biosystems Silencer® siRNAs for OIT3
Sigma-Aldrich siRNA for OIT3  Sigma-Aldrich shRNA for OIT3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152635                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152635                                  untagged cDNA clone in CMV expression vector: NM_152635 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_152635
UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8Function: May be involved in hepatocellular function and development1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- | About this table | Pathways & Interactions for OIT3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| -- |
Drugs & Compounds for OIT3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for OIT3
|
Transcripts for OIT3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152635
Sigma-Aldrich siRNA for OIT3  Sigma-Aldrich shRNA for OIT3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_152635 REFSEQ mRNAs for OIT3 gene: NM_152635.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_152635               OriGene GFP tagged cDNA clone in CMV expression vector: NM_152635                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152635                                  untagged cDNA clone in CMV expression vector: NM_152635  Additional cDNA sequence: AF075085.1 AK096435.1 AY013707.2 AY358339.1 BC126440.1 4 DOTS entries: DT.95128719 DT.100746234 DT.113412 DT.306879 24/52 AceView cDNA sequences (see all 52
):AV695874 AI287565 AV651238 BF592796 BX498775 AY358339 AA340890 AV651182 AF075085 AV651191 NM_152635 AA430114 AK096435 T40097 AV651225 AW590571 AY013707 BX279604 AV650082 AV651252 H94467 AV651977 AA693997 H58673
highest scoring ESTs for OIT3:AA702703 AK096435 AY013707 AY358339 AA430114 AA677443 AA693997 AF075085 AI096996 AI287565 Unigene Cluster for OIT3: Oncoprotein induced transcript 3 Hs.8366 [show with all ESTs]Unigene Representative Sequence: AK096435
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for OIT3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for OIT3
1 Ensembl transcript including schematic representation: ENST00000334011
|
Expression for OIT3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OIT3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OIT3
1 / 2 / 3 3 probe-sets matching OIT3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGATCTTCCC
SOURCE GeneReport for Unigene cluster: Hs.8366 UniProtKB/Swiss-Prot: OIT3_HUMAN, Q8WWZ8Tissue specificity: Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines |
Orthologs for OIT3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OIT3 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for OIT3
ENSEMBL Gene Tree for OIT3 | Paralogs for OIT3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for OIT3 gene
- GP22 UMOD2
|
SNPs/Variants for OIT3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OIT3 (up to first 250kb)
|
Disorders & Mutations for OIT3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609330
|
Medical News for OIT3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OIT3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for OIT3 gene:- A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. (PubMed id 12939600)1, 2, 3, 4 Xu Z.G....Han Z.G. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)2, 3, 4 Clark H.F....Gray A. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (PubMed id 15589826)1, 3 Yang H....Guo J. (2004)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)4 Chen R.... Zou H. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory protein. (PubMed id 15346761)1 Xu Z.G....Han Z.G. (2004)
|
Search for OIT3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OIT3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OIT3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OIT3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for OIT3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OIT3:

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| | Recombinant Proteins (OIT3) | | Antibodies (OIT3) |
| | | Search Tocris compounds for OIT3 |
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Incremental update: 13 Oct 2009
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