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Aliases for OIT3 Gene

Aliases for OIT3 Gene

  • Oncoprotein Induced Transcript 3 2 3 5
  • Liver-Specific Zona Pellucida Domain-Containing Protein 3 4
  • LZP 3 4
  • Liver-Specific ZP Domain-Containing Protein 3

External Ids for OIT3 Gene

Previous GeneCards Identifiers for OIT3 Gene

  • GC10P073998
  • GC10P074323
  • GC10P074654
  • GC10P068647

Summaries for OIT3 Gene

GeneCards Summary for OIT3 Gene

OIT3 (Oncoprotein Induced Transcript 3) is a Protein Coding gene. Diseases associated with OIT3 include Familial Juvenile Hyperuricaemic Nephropathy. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is GP2.

UniProtKB/Swiss-Prot for OIT3 Gene

  • May be involved in hepatocellular function and development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OIT3 Gene

Genomics for OIT3 Gene

Regulatory Elements for OIT3 Gene

Enhancers for OIT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OIT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OIT3 Gene

72,893,556 bp from pter
72,933,036 bp from pter
39,481 bases
Plus strand

Genomic View for OIT3 Gene

Genes around OIT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OIT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OIT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OIT3 Gene

Proteins for OIT3 Gene

  • Protein details for OIT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oncoprotein-induced transcript 3 protein
    Protein Accession:
    Secondary Accessions:
    • A0AVP3
    • Q8N1M8

    Protein attributes for OIT3 Gene

    545 amino acids
    Molecular mass:
    60022 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OIT3 Gene


neXtProt entry for OIT3 Gene

Proteomics data for OIT3 Gene at MOPED

Post-translational modifications for OIT3 Gene

  • Glycosylation at Asn 89, Asn 116, Asn 291, and Asn 299
  • Modification sites at PhosphoSitePlus

Other Protein References for OIT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OIT3 Gene

Domains & Families for OIT3 Gene

Suggested Antigen Peptide Sequences for OIT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EGF-like domain.
  • Contains 1 EGF-like domain.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with OIT3: view

No data available for Gene Families for OIT3 Gene

Function for OIT3 Gene

Molecular function for OIT3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in hepatocellular function and development.

Gene Ontology (GO) - Molecular Function for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with OIT3: view
genes like me logo Genes that share phenotypes with OIT3: view

Animal Models for OIT3 Gene

MGI Knock Outs for OIT3:

Animal Model Products

  • Taconic Biosciences Mouse Models for OIT3

miRNA for OIT3 Gene

miRTarBase miRNAs that target OIT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OIT3 Gene

Localization for OIT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OIT3 Gene

Nucleus envelope. Note=Can be secreted into blood.

Subcellular locations from

Jensen Localization Image for OIT3 Gene COMPARTMENTS Subcellular localization image for OIT3 gene
Compartment Confidence
extracellular 3
nucleus 3
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for OIT3 Gene

Pathways & Interactions for OIT3 Gene

SuperPathways for OIT3 Gene

No Data Available

Interacting Proteins for OIT3 Gene

Selected Interacting proteins: Q8WWZ8-OIT3_HUMAN for OIT3 Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for OIT3 Gene


No data available for Pathways by source and SIGNOR curated interactions for OIT3 Gene

Drugs & Compounds for OIT3 Gene

No Compound Related Data Available

Transcripts for OIT3 Gene

mRNA/cDNA for OIT3 Gene

Unigene Clusters for OIT3 Gene

Oncoprotein induced transcript 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OIT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP2: -

Relevant External Links for OIT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OIT3 Gene

mRNA expression in normal human tissues for OIT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OIT3 Gene

This gene is overexpressed in Liver (x33.8) and Spleen (x10.6).

Protein differential expression in normal tissues from HIPED for OIT3 Gene

This gene is overexpressed in Serum (49.8) and Plasma (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OIT3 Gene

SOURCE GeneReport for Unigene cluster for OIT3 Gene Hs.8366

mRNA Expression by UniProt/SwissProt for OIT3 Gene

Tissue specificity: Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines.
genes like me logo Genes that share expression patterns with OIT3: view

Protein tissue co-expression partners for OIT3 Gene

Primer Products

Orthologs for OIT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OIT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OIT3 35
  • 90.27 (n)
  • 93.07 (a)
-- 36
  • 56 (a)
-- 36
  • 93 (a)
(Canis familiaris)
Mammalia OIT3 35
  • 91.01 (n)
  • 93.58 (a)
OIT3 36
  • 90 (a)
(Mus musculus)
Mammalia Oit3 35
  • 85.63 (n)
  • 89.72 (a)
Oit3 16
Oit3 36
  • 89 (a)
(Pan troglodytes)
Mammalia OIT3 35
  • 99.39 (n)
  • 99.27 (a)
OIT3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Oit3 35
  • 86.61 (n)
  • 91.19 (a)
(Monodelphis domestica)
Mammalia OIT3 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia OIT3 36
  • 84 (a)
(Gallus gallus)
Aves OIT3 35
  • 75.15 (n)
  • 80.81 (a)
OIT3 36
  • 80 (a)
(Anolis carolinensis)
Reptilia OIT3 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia oit3 35
  • 71.07 (n)
  • 77.06 (a)
(Danio rerio)
Actinopterygii LOC100535938 35
  • 63.54 (n)
  • 64.35 (a)
CU856520.1 36
  • 63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
-- 36
  • 17 (a)
-- 36
  • 18 (a)
-- 36
  • 20 (a)
CSA.3943 36
  • 16 (a)
Species with no ortholog for OIT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OIT3 Gene

Gene Tree for OIT3 (if available)
Gene Tree for OIT3 (if available)

Paralogs for OIT3 Gene

Paralogs for OIT3 Gene

genes like me logo Genes that share paralogs with OIT3: view

Variants for OIT3 Gene

Sequence variations from dbSNP and Humsavar for OIT3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs35089256 - 72,911,758(+) GCCAC(C/T)CTTGC nc-transcript-variant, reference, missense
rs1916573 -- 72,916,159(-) TAAAA(A/C)TAAGC intron-variant
rs3208076 -- 72,932,085(-) TCCTG(C/T)ATGGA intron-variant
rs3750736 -- 72,911,853(-) CCCCT(A/G)CCCCA intron-variant
rs7090452 -- 72,917,242(+) tgcct(C/G)tgtct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OIT3 Gene

Variant ID Type Subtype PubMed ID
nsv528473 CNV Gain 19592680

Variation tolerance for OIT3 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OIT3 Gene

Disorders for OIT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OIT3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial juvenile hyperuricaemic nephropathy
  • familial juvenile hyperuricemic nephropathy
- elite association - COSMIC cancer census association via MalaCards
Search OIT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OIT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OIT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OIT3 Gene

Publications for OIT3 Gene

  1. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. (PMID: 12939600) Xu Z.-G. … Han Z.-G. (Hepatology 2003) 2 3 4 23 67
  2. Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (PMID: 15589826) Yang H. … Guo J. (FEBS Lett. 2004) 3 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  4. Loss of heterozygosity at the calcium regulation gene locus on chromosome 10q in human pancreatic cancer. (PMID: 25824785) Long J. … Ge C.L. (Asian Pac. J. Cancer Prev. 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for OIT3 Gene

Sources for OIT3 Gene