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Aliases for OIT3 Gene

Aliases for OIT3 Gene

  • Oncoprotein Induced Transcript 3 2 3 5
  • Liver-Specific Zona Pellucida Domain-Containing Protein 3 4
  • LZP 3 4
  • Liver-Specific ZP Domain-Containing Protein 3
  • Oncoprotein-Induced Transcript 3 Protein 3

External Ids for OIT3 Gene

Previous GeneCards Identifiers for OIT3 Gene

  • GC10P073998
  • GC10P074323
  • GC10P074654
  • GC10P068647

Summaries for OIT3 Gene

Entrez Gene Summary for OIT3 Gene

  • This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]

GeneCards Summary for OIT3 Gene

OIT3 (Oncoprotein Induced Transcript 3) is a Protein Coding gene. Diseases associated with OIT3 include Familial Juvenile Hyperuricaemic Nephropathy. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is GP2.

UniProtKB/Swiss-Prot for OIT3 Gene

  • May be involved in hepatocellular function and development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OIT3 Gene

Genomics for OIT3 Gene

Regulatory Elements for OIT3 Gene

Enhancers for OIT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F072782 1.3 FANTOM5 Ensembl ENCODE 9.7 -109.6 -109631 3.6 KLF1 PKNOX1 CEBPG ZNF664 ZFHX2 ZBTB48 POLR2A ZNF239 PRDM10 FOS DNAJB12 OIT3 ENSG00000226163 ENSG00000272627
GH10F072951 1.1 Ensembl ENCODE 10.4 +60.4 60366 4.2 ELF3 ATF1 ARID4B DMAP1 YY1 SCRT2 CREM MIXL1 EGR2 CEBPB CFAP70 NUDT13 OIT3 ECD DNAJB12 DNAJC9-AS1 PLA2G12B NPM1P24
GH10F071919 1.2 Ensembl ENCODE 9.3 -972.1 -972123 4.3 HDAC1 ATF1 PKNOX1 KLF17 SCRT2 CREM EGR2 ZNF362 REST TSHZ1 OIT3 VSIR PSAP GC10M071945 ENSG00000230526
GH10F072727 1.1 Ensembl ENCODE 9.9 -164.0 -163962 3.4 SOX13 TFAP4 ZNF664 ZFHX2 HOMEZ EGR2 GATAD2A SOX5 SMARCE1 ZNF362 DNAJB12 ENSG00000226163 OIT3 CFAP70 ENSG00000280166 MIR4676
GH10F072845 0.9 Ensembl ENCODE 11 -47.2 -47153 1.2 JUN CEBPB EP300 RFX5 JUND POLR3A ZBTB33 FOS MAFK DNAJC9 MCU OIT3 RNU6-805P ENSG00000226163 RPL26P6 ZSWIM8 ENSG00000272627
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OIT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OIT3 Gene

72,893,556 bp from pter
72,933,036 bp from pter
39,481 bases
Plus strand

Genomic View for OIT3 Gene

Genes around OIT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OIT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OIT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OIT3 Gene

Proteins for OIT3 Gene

  • Protein details for OIT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oncoprotein-induced transcript 3 protein
    Protein Accession:
    Secondary Accessions:
    • A0AVP3
    • Q8N1M8

    Protein attributes for OIT3 Gene

    545 amino acids
    Molecular mass:
    60022 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OIT3 Gene


neXtProt entry for OIT3 Gene

Post-translational modifications for OIT3 Gene

  • Glycosylation at Asn 89, Asn 116, Asn 291, and Asn 299
  • Modification sites at PhosphoSitePlus

Other Protein References for OIT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OIT3 Gene

Domains & Families for OIT3 Gene

Suggested Antigen Peptide Sequences for OIT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EGF-like domain.
  • Contains 1 EGF-like domain.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with OIT3: view

No data available for Gene Families for OIT3 Gene

Function for OIT3 Gene

Molecular function for OIT3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in hepatocellular function and development.

Gene Ontology (GO) - Molecular Function for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with OIT3: view
genes like me logo Genes that share phenotypes with OIT3: view

Animal Models for OIT3 Gene

MGI Knock Outs for OIT3:

Animal Model Products

  • Taconic Biosciences Mouse Models for OIT3

miRNA for OIT3 Gene

miRTarBase miRNAs that target OIT3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OIT3 Gene

Localization for OIT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OIT3 Gene

Nucleus envelope. Note=Can be secreted into blood.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OIT3 gene
Compartment Confidence
extracellular 3
nucleus 3
plasma membrane 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
genes like me logo Genes that share ontologies with OIT3: view

Pathways & Interactions for OIT3 Gene

No Data Available

Interacting Proteins for OIT3 Gene

Selected Interacting proteins: Q8WWZ8-OIT3_HUMAN for OIT3 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903118 urate homeostasis IEA --
genes like me logo Genes that share ontologies with OIT3: view

No data available for Pathways by source and SIGNOR curated interactions for OIT3 Gene

Transcripts for OIT3 Gene

mRNA/cDNA for OIT3 Gene

Unigene Clusters for OIT3 Gene

Oncoprotein induced transcript 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OIT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP2: -

Relevant External Links for OIT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OIT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OIT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OIT3 Gene

This gene is overexpressed in Liver (x33.8) and Spleen (x10.6).

Protein differential expression in normal tissues from HIPED for OIT3 Gene

This gene is overexpressed in Serum (49.8) and Plasma (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OIT3 Gene

Protein tissue co-expression partners for OIT3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OIT3 Gene:


SOURCE GeneReport for Unigene cluster for OIT3 Gene:


mRNA Expression by UniProt/SwissProt for OIT3 Gene:

Tissue specificity: Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines.
genes like me logo Genes that share expression patterns with OIT3: view

Primer Products

Orthologs for OIT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OIT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OIT3 34 35
  • 99.39 (n)
(Bos Taurus)
Mammalia -- 35
  • 93 (a)
OIT3 34
  • 90.27 (n)
-- 35
  • 56 (a)
(Canis familiaris)
Mammalia OIT3 34 35
  • 91.01 (n)
(Rattus norvegicus)
Mammalia Oit3 34
  • 86.61 (n)
(Mus musculus)
Mammalia Oit3 34 16 35
  • 85.63 (n)
(Ornithorhynchus anatinus)
Mammalia OIT3 35
  • 84 (a)
(Monodelphis domestica)
Mammalia OIT3 35
  • 72 (a)
(Gallus gallus)
Aves OIT3 34 35
  • 75.15 (n)
(Anolis carolinensis)
Reptilia OIT3 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia oit3 34
  • 71.07 (n)
(Danio rerio)
Actinopterygii LOC100535938 34
  • 63.54 (n)
CU856520.1 35
  • 63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
-- 35
  • 18 (a)
-- 35
  • 17 (a)
CSA.3943 35
  • 16 (a)
-- 35
  • 12 (a)
Species where no ortholog for OIT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OIT3 Gene

Gene Tree for OIT3 (if available)
Gene Tree for OIT3 (if available)

Paralogs for OIT3 Gene

Paralogs for OIT3 Gene

genes like me logo Genes that share paralogs with OIT3: view

Variants for OIT3 Gene

Sequence variations from dbSNP and Humsavar for OIT3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs145480078 Uncertain significance 72,932,484(+) CCAGA(C/T)GCTAA nc-transcript-variant, reference, missense
rs11000439 -- 72,897,047(+) gagac(A/G)aagtt intron-variant
rs11000440 -- 72,902,346(+) AATAC(A/G)TTTAA intron-variant
rs11000441 -- 72,904,011(+) CCGGC(A/G)CCACA intron-variant
rs11000442 -- 72,904,027(+) GGCCT(C/G)GTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OIT3 Gene

Variant ID Type Subtype PubMed ID
nsv528473 CNV gain 19592680
nsv948063 CNV duplication 23825009

Variation tolerance for OIT3 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OIT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OIT3 Gene

Disorders for OIT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OIT3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial juvenile hyperuricaemic nephropathy
  • familial juvenile hyperuricemic nephropathy
- elite association - COSMIC cancer census association via MalaCards
Search OIT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OIT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OIT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OIT3 Gene

Publications for OIT3 Gene

  1. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. (PMID: 12939600) Xu Z.-G. … Han Z.-G. (Hepatology 2003) 2 3 4 22 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (PMID: 15589826) Yang H. … Guo J. (FEBS Lett. 2004) 3 22 64
  5. Loss of heterozygosity at the calcium regulation gene locus on chromosome 10q in human pancreatic cancer. (PMID: 25824785) Long J. … Ge C.L. (Asian Pac. J. Cancer Prev. 2015) 3 64

Products for OIT3 Gene

Sources for OIT3 Gene

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