Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OIT3 Gene

Aliases for OIT3 Gene

  • Oncoprotein Induced Transcript 3 2 3
  • LZP 3 4 6
  • Liver-Specific Zona Pellucida Domain-Containing Protein 3 4
  • Liver-Specific ZP Domain-Containing Protein 3
  • Oncoprotein-Induced Transcript 3 Protein 3

External Ids for OIT3 Gene

Previous GeneCards Identifiers for OIT3 Gene

  • GC10P073998
  • GC10P074323
  • GC10P074654
  • GC10P068647

Summaries for OIT3 Gene

GeneCards Summary for OIT3 Gene

OIT3 (Oncoprotein Induced Transcript 3) is a Protein Coding gene. Diseases associated with OIT3 include familial juvenile hyperuricaemic nephropathy. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is UMOD.

UniProtKB/Swiss-Prot for OIT3 Gene

  • May be involved in hepatocellular function and development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OIT3 Gene

Genomics for OIT3 Gene

Regulatory Elements for OIT3 Gene

Genomic Location for OIT3 Gene

Start:
72,893,556 bp from pter
End:
72,933,137 bp from pter
Size:
39,582 bases
Orientation:
Plus strand

Genomic View for OIT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OIT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OIT3 Gene

Proteins for OIT3 Gene

  • Protein details for OIT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWZ8-OIT3_HUMAN
    Recommended name:
    Oncoprotein-induced transcript 3 protein
    Protein Accession:
    Q8WWZ8
    Secondary Accessions:
    • A0AVP3
    • Q8N1M8

    Protein attributes for OIT3 Gene

    Size:
    545 amino acids
    Molecular mass:
    60022 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OIT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OIT3 Gene

Proteomics data for OIT3 Gene at MOPED

Post-translational modifications for OIT3 Gene

  • Glycosylation at Asn89, Asn116, Asn291, and Asn299
  • Modification sites at PhosphoSitePlus

Other Protein References for OIT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OIT3 Gene

Domains for OIT3 Gene

Suggested Antigen Peptide Sequences for OIT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWZ8

UniProtKB/Swiss-Prot:

OIT3_HUMAN :
  • Q8WWZ8
Domain:
  • Contains 1 EGF-like domain.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with OIT3: view

No data available for Gene Families for OIT3 Gene

Function for OIT3 Gene

Molecular function for OIT3 Gene

UniProtKB/Swiss-Prot Function: May be involved in hepatocellular function and development.

Gene Ontology (GO) - Molecular Function for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with OIT3: view

Phenotypes for OIT3 Gene

genes like me logo Genes that share phenotypes with OIT3: view

Animal Models for OIT3 Gene

MGI Knock Outs for OIT3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OIT3 Gene

Localization for OIT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OIT3 Gene

Nucleus envelope. Note=Can be secreted into blood.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OIT3 Gene COMPARTMENTS Subcellular localization image for OIT3 gene
Compartment Confidence
nucleus 5
extracellular 3
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope IEA --
genes like me logo Genes that share ontologies with OIT3: view

Pathways for OIT3 Gene

SuperPathways for OIT3 Gene

No Data Available

Interacting Proteins for OIT3 Gene

Selected Interacting proteins: Q8WWZ8-OIT3_HUMAN for OIT3 Gene via UniProtKB

Symbol External ID(s) Details
MEOX2

Gene Ontology (GO) - Biological Process for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903118 urate homeostasis IEA --
genes like me logo Genes that share ontologies with OIT3: view

No data available for Pathways by source for OIT3 Gene

Transcripts for OIT3 Gene

mRNA/cDNA for OIT3 Gene

(52) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OIT3 Gene

Oncoprotein induced transcript 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OIT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2: -

Relevant External Links for OIT3 Gene

GeneLoc Exon Structure for
OIT3
ECgene alternative splicing isoforms for
OIT3

Expression for OIT3 Gene

mRNA expression in normal human tissues for OIT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OIT3 Gene

This gene is overexpressed in Liver (33.8) and Spleen (10.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OIT3 Gene

SOURCE GeneReport for Unigene cluster for OIT3 Gene Hs.8366

mRNA Expression by UniProt/SwissProt for OIT3 Gene

Q8WWZ8-OIT3_HUMAN
Tissue specificity: Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines.
genes like me logo Genes that share expressions with OIT3: view

Orthologs for OIT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OIT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OIT3 35
  • 99.39 (n)
  • 99.27 (a)
OIT3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
OIT3 35
  • 90.27 (n)
  • 93.07 (a)
dog
(Canis familiaris)
Mammalia OIT3 35
  • 91.01 (n)
  • 93.58 (a)
OIT3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oit3 35
  • 85.63 (n)
  • 89.72 (a)
Oit3 16
Oit3 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OIT3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OIT3 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oit3 35
  • 86.61 (n)
  • 91.19 (a)
chicken
(Gallus gallus)
Aves OIT3 35
  • 75.15 (n)
  • 80.81 (a)
OIT3 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OIT3 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oit3 35
  • 71.07 (n)
  • 77.06 (a)
zebrafish
(Danio rerio)
Actinopterygii CU856520.1 36
  • 63 (a)
OneToOne
LOC100535938 35
  • 63.54 (n)
  • 64.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
OneToMany
-- 36
  • 17 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 20 (a)
OneToMany
CSA.3943 36
  • 16 (a)
OneToMany
Species with no ortholog for OIT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OIT3 Gene

ENSEMBL:
Gene Tree for OIT3 (if available)
TreeFam:
Gene Tree for OIT3 (if available)

Paralogs for OIT3 Gene

Paralogs for OIT3 Gene

genes like me logo Genes that share paralogs with OIT3: view

Variants for OIT3 Gene

Sequence variations from dbSNP and Humsavar for OIT3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1316943 -- 72,892,144(+) AAATT(C/T)TTCAT upstream-variant-2KB
rs1916573 -- 72,916,159(-) TAAAA(A/C)TAAGC intron-variant
rs2394930 -- 72,906,326(-) CTTTT(C/G)AGTCG intron-variant
rs2394931 -- 72,906,307(-) CCTAC(C/T)TATTT intron-variant
rs2461918 -- 72,930,996(-) ATTTG(C/T)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OIT3 Gene

Variant ID Type Subtype PubMed ID
nsv528473 CNV Gain 19592680

Relevant External Links for OIT3 Gene

HapMap Linkage Disequilibrium report
OIT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OIT3 Gene

Disorders for OIT3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for OIT3 Gene including...

Search for OIT3 Gene in MalaCards »
genes like me logo Genes that share disorders with OIT3: view

No data available for UniProtKB/Swiss-Prot for OIT3 Gene

Publications for OIT3 Gene

  1. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. (PMID: 12939600) Xu Z.-G. … Han Z.-G. (Hepatology 2003) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (PMID: 15589826) Yang H. … Guo J. (FEBS Lett. 2004) 3 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OIT3 Gene

Sources for OIT3 Gene

Back to Top

Content