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Aliases for OIP5 Gene

Aliases for OIP5 Gene

  • Opa Interacting Protein 5 2 3 5
  • Cancer/Testis Antigen 86 2 3 4
  • Opa-Interacting Protein 5 3 4
  • MIS18B 3 4
  • CT86 3 4
  • MIS18 Kinetochore Protein Homolog B (S. Pombe) 2
  • MIS18 Kinetochore Protein Homolog B 3
  • LAP2alpha Interactor-25 3
  • 5730547N13Rik 3
  • HMIS18beta 3
  • MIS18beta 3
  • LINT-25 3
  • OIP-5 4

External Ids for OIP5 Gene

Previous GeneCards Identifiers for OIP5 Gene

  • GC15M036969
  • GC15M034497
  • GC15M039180
  • GC15M039317
  • GC15M039389
  • GC15M041601
  • GC15M018455

Summaries for OIP5 Gene

Entrez Gene Summary for OIP5 Gene

  • The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for OIP5 Gene

OIP5 (Opa Interacting Protein 5) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Chromosome Maintenance.

UniProtKB/Swiss-Prot for OIP5 Gene

  • Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OIP5 Gene

Genomics for OIP5 Gene

Regulatory Elements for OIP5 Gene

Promoters for OIP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OIP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OIP5 Gene

Chromosome:
15
Start:
41,309,268 bp from pter
End:
41,332,729 bp from pter
Size:
23,462 bases
Orientation:
Minus strand

Genomic View for OIP5 Gene

Genes around OIP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OIP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OIP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OIP5 Gene

Proteins for OIP5 Gene

  • Protein details for OIP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43482-MS18B_HUMAN
    Recommended name:
    Protein Mis18-beta
    Protein Accession:
    O43482
    Secondary Accessions:
    • Q96BX7

    Protein attributes for OIP5 Gene

    Size:
    229 amino acids
    Molecular mass:
    24691 Da
    Quaternary structure:
    • Homodimer, and heterodimer with MIS18A. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4. Binds outer membrane protein OpaP from Neisseria gonorrhoeae.
    SequenceCaution:
    • Sequence=AAC39561.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OIP5 Gene

Proteomics data for OIP5 Gene at MOPED

Post-translational modifications for OIP5 Gene

  • Ubiquitination at Lys 215
  • Modification sites at PhosphoSitePlus

Other Protein References for OIP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OIP5 Gene

Domains & Families for OIP5 Gene

Protein Domains for OIP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OIP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OIP5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OIP5 Gene

Function for OIP5 Gene

Molecular function for OIP5 Gene

UniProtKB/Swiss-Prot Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
genes like me logo Genes that share phenotypes with OIP5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OIP5 Gene

Localization for OIP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OIP5 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OIP5 Gene COMPARTMENTS Subcellular localization image for OIP5 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0010369 chromocenter IEA --
GO:0015030 Cajal body IDA 17284516
genes like me logo Genes that share ontologies with OIP5: view

Pathways & Interactions for OIP5 Gene

genes like me logo Genes that share pathways with OIP5: view

Gene Ontology (GO) - Biological Process for OIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with OIP5: view

No data available for SIGNOR curated interactions for OIP5 Gene

Drugs & Compounds for OIP5 Gene

No Compound Related Data Available

Transcripts for OIP5 Gene

mRNA/cDNA for OIP5 Gene

Unigene Clusters for OIP5 Gene

Opa interacting protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OIP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for OIP5 Gene

GeneLoc Exon Structure for
OIP5
ECgene alternative splicing isoforms for
OIP5

Expression for OIP5 Gene

mRNA expression in normal human tissues for OIP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OIP5 Gene

This gene is overexpressed in Testis (x11.7) and Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for OIP5 Gene

This gene is overexpressed in Fetal ovary (32.0), Testis (21.1), and Ovary (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OIP5 Gene



SOURCE GeneReport for Unigene cluster for OIP5 Gene Hs.661645

genes like me logo Genes that share expression patterns with OIP5: view

Protein tissue co-expression partners for OIP5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for OIP5 Gene

Orthologs for OIP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OIP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OIP5 35
  • 86.32 (n)
  • 82.1 (a)
OIP5 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OIP5 35
  • 86.03 (n)
  • 82.53 (a)
OIP5 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oip5 35
  • 80.13 (n)
  • 71.72 (a)
Oip5 16
Oip5 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OIP5 35
  • 99.42 (n)
  • 98.69 (a)
OIP5 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OIP5 36
  • 26 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OIP5 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves OIP5 35
  • 57 (n)
  • 46.15 (a)
OIP5 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii oip5 36
  • 27 (a)
OneToOne
Species with no ortholog for OIP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OIP5 Gene

ENSEMBL:
Gene Tree for OIP5 (if available)
TreeFam:
Gene Tree for OIP5 (if available)

Paralogs for OIP5 Gene

Pseudogenes.org Pseudogenes for OIP5 Gene

genes like me logo Genes that share paralogs with OIP5: view

No data available for Paralogs for OIP5 Gene

Variants for OIP5 Gene

Sequence variations from dbSNP and Humsavar for OIP5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs7161772 -- 41,318,868(+) ttttt(A/T)aaatt intron-variant
rs7163989 -- 41,322,423(+) agaca(A/G)gttct intron-variant
rs6493000 -- 41,320,902(+) cccat(C/G)gtctg intron-variant
rs7168307 -- 41,328,336(+) agatg(A/G)aacaa intron-variant
rs7181560 -- 41,330,595(+) agaca(C/G)ggttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OIP5 Gene

Variant ID Type Subtype PubMed ID
esv25344 CNV Gain 19812545
esv2749606 CNV Deletion 23290073
esv2667320 CNV Deletion 23128226
esv2661625 CNV Deletion 23128226

Variation tolerance for OIP5 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OIP5 Gene

HapMap Linkage Disequilibrium report
OIP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OIP5 Gene

Disorders for OIP5 Gene

Relevant External Links for OIP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OIP5

No disorders were found for OIP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OIP5 Gene

Publications for OIP5 Gene

  1. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. (PMID: 17199038) Fujita Y. … Yanagida M. (Dev. Cell 2007) 2 3 4 67
  2. OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers. (PMID: 20510019) Chun H.K. … Lee H.G. (BMB Rep 2010) 3 23
  3. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. (PMID: 9466265) Williams J.M. … Rest R.F. (Mol. Microbiol. 1998) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. I^TrCP-mediated ubiquitylation regulates protein stability of Mis18I^ in a cell cycle-dependent manner. (PMID: 24269809) Kim I.S. … Kim K.I. (Biochem. Biophys. Res. Commun. 2014) 3

Products for OIP5 Gene

Sources for OIP5 Gene

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