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OIP5 Gene

protein-coding   GIFtS: 50

GC15M039389
Opa interacting protein 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
5730547N13Rik 2
CT86 3
LINT-25 2
MIS18B 3
MIS18beta 2
Descriptions
Cancer/testis antigen 86 3
LAP2alpha interactor-25 2
Opa interacting protein 5 2
Opa-interacting protein 5 3
External Ids
HGNC: 203001
Entrez Gene: 113392
UniProtKB: O434823
Ensembl: ENSG000001041477
Search outside databases for aliases for OIP5 gene

Previous GC identifers: GC15M036969 GC15M034497 GC15M039180 GC15M039317

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: MS18B_HUMAN, O43482
Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during
mitosis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OIP5 gene  

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14

OIP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M039389:     (about GC identifiers)

Start:
39,388,758 bp from pter
End:
39,412,111 bp from pter
Size:
23,354 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000015.8  NT_010194.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MS18B_HUMAN, O43482 (See protein sequence)
Recommended Name: Protein Mis18-beta  
Size: 229 amino acids; 24691 Da
Subunit: Homodimer, and heterodimer with MIS18A. Identified in a complex containing MIS18A, MIS18B,
MIS18BP1, RBBP7 and RBBP4. Binds outer membrane protein OpaP from Neisseria gonorrhoeae
Subcellular location: Nucleus. Centromere. Note=Associated with centromeres in interphase cells,
from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis.
Associated with chromatin
Secondary accessions: Q96BX7

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_009211.1  

    ENSEMBL proteins: 
    ENSP00000220514 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (OIP5)
    Human Recombinant Proteins from Abnova (OIP5)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775 chromosome, centromeric region IEA--
    GO:0000785 chromatin IDA17284516
    GO:0005575 cellular_component ND--
    GO:0005634 nucleus IDA17284516
    GO:0010369 chromocenter IEA--
    About this table

    Antibodies for OIP5: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for OIP5
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (OIP5), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (OIP5)
    Novus Biologicals Antibodies for OIP5

    Assays for OIP5: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O43482

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (OIP5)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (OIP5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007280

                  Applied Biosystems Silencer® siRNAs for OIP5

                  Sigma-Aldrich siRNA for OIP5  
                         Sigma-Aldrich shRNA for OIP5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for OIP5
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007280
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007280
                                     untagged cDNA clone in CMV expression vector: NM_007280 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_007280

    UniProtKB/Swiss-Prot: MS18B_HUMAN, O43482
    Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during
    mitosis

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding TAS9466265
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5 Interacting proteins for OIP5 (ENSP000002205143 O434821) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAF1P040491EBI-536879, EBI-365996
    TRIP6ENSP000002004573STRING (score=.953)
    PRAMEENSP000003514323STRING (score=.855)
    EXOSC8ENSP000003743543STRING (score=.841)
    --ENSP000003737443STRING (score=.841)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049 cell cycle IEA--
    GO:0007067 mitosis IEA--
    GO:0007154 cell communication NAS9466265
    GO:0051301 cell division IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for OIP5

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (OIP5)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (OIP5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007280

                  Sigma-Aldrich siRNA for OIP5  
                         Sigma-Aldrich shRNA for OIP5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_007280  

    REFSEQ mRNAs for OIP5 gene: 

    NM_007280.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_007280  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007280
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007280
                                     untagged cDNA clone in CMV expression vector: NM_007280 

    Additional cDNA sequence: 

    AF025441.1 BC015050.1 CR603974.1 

    4 DOTS entries:

    DT.111704  DT.121040770  DT.306624  DT.95279554 

    24/51 AceView cDNA sequences (see all 51 ):

    BM784603 BU620714 BE778254 AF025441 AI953118 AA767724 BG503804 CR603974 
    BM762104 BE048189 NM_007280 BQ651609 CB157707 BC015050 AA743696 BM846325 
    BQ217755 AI394114 BF035661 BE385809 BI552750 BG498569 AW957943 BM806431 

    highest scoring ESTs for OIP5:

    AF025441 AA308351 AL574729 AW957943 BC015050 BE048189 BE385809 BE567716 BE778254 BE882633 

    Unigene Cluster for OIP5:

    Opa interacting protein 5
    Hs.661645  [show with all ESTs]
    Unigene Representative Sequence: BQ218042


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for OIP5

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                    -                     

    About this scheme

    ECgene alternative splicing isoforms for OIP5

    1 Ensembl transcript including schematic representation:
    ENST00000220514  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    OIP5 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for OIP5

    1 / 2 / 3

    3 probe-sets matching OIP5 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    37474_at2, 3 U95-A 1 0.94 1.00 1.00 1.00 AF025441 1.00 1.00 1.00 1

    213599_at2, 3 U133-A 1 1.00 1.00 -- -- BE045993 0.60 1.00 0.82 1

    213599_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAGCAGTTGT

    SOURCE GeneReport for Unigene cluster: Hs.661645

    Expression variation in blood from EXPOLDB for OIP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for OIP5 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    OIP51   -- Opa interacting protein 5 86.03(n)
    82.53(a)
    608635  XM_845719.1  XP_850812.1 
    chimpanzee
    (Pan troglodytes)
    OIP51   -- Opa interacting protein 5 99.42(n)
    98.69(a)
    453347  XM_510321.2  XP_510321.2 
    cow
    (Bos taurus)
    OIP51   -- Opa interacting protein 5 86.32(n)
    82.1(a)
    511100  XM_588370.3  XP_588370.2 
    rat
    (Rattus norvegicus)
    RGD15642631   -- similar to Opa-interacting protein 5 79.34(n)
    73.96(a)
    499873  XM_575214.2  XP_575214.2 
    mouse
    (Mus musculus)
    Oip51, 5 25
    Opa interacting protein 51, 5 80.13(n)1
    71.72(a)1
    706451  NM_001042653.11  NP_001036118.11 
     AK0178255  AK0453235  (see all 10)
    About this table        Species with no ortholog for OIP5

    ENSEMBL Gene Tree for OIP5
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/90 NCBI SNPs in OIP5 are shown (see all 90 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 30)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs93021091,2
    A,C,F,H39399472(+) CCCTCG/TTATAT 1 -- int14Minor allele frequency- T:0.32EU EA WA 420
    rs80364981,2
    A,C,F,H39390568(+) gctgaA/Ggcaga 1 -- int14Minor allele frequency- G:0.32EU EA WA 416
    rs71683071,2
    A,C,F,H39407826(+) agatgA/Gaacaa 1 -- int14Minor allele frequency- G:0.18EU EA WA 418
    rs80328461,2
    A,C,F,H39392945(+) GCCTGC/GCTTCT 1 -- int111Minor allele frequency- G:0.26EU EA WA NA 916
    rs80328381,2
    A,C,F,H39392924(+) AGAAAG/ATATGT 1 -- int18Minor allele frequency- A:0.32EU EA WA NA 764
    --
    rs71695431,2
    A,C,F39407697(+) agagaT/Cgaagt 1 -- int13Minor allele frequency- C:0.02NA 142
    --
    rs110703271,2
    C,F,H39390158(+) GTTTCA/GTGTGA 1 -- int112Minor allele frequency- N:0.00EU EA WA NA 1054
    rs71819821,2
    F,H39410312(+) tatgaC/Gtagtg 1 -- int14Minor allele frequency- G:0.10EU EA WA 418
    --
    rs80330951,2
    F,H39393308(+) tgtccA/Gtggat 1 -- int14Minor allele frequency- G:0.05EU EA WA 414
    rs80381851,2
    F,H39404524(+) ttgtgG/Acatcc 1 -- int14Minor allele frequency- A:0.02EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for OIP5 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606020

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    7 PubMed articles for OIP5 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 11339 HGNC: 20300 AceView: OIP5 Ensembl:ENSG00000104147 euGenes: HUgn11339
    ECgene: OIP5 H-InvDB: OIP5
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for OIP5:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for OIP5 Antibodies for OIP5
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for OIP5 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search OriGene for OIP5
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     Antibodies for OIP5

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