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Aliases for OIP5 Gene

Aliases for OIP5 Gene

  • Opa Interacting Protein 5 2 3
  • Cancer/Testis Antigen 86 2 3 4
  • Opa-Interacting Protein 5 3 4
  • MIS18B 3 4
  • OIP-5 3 4
  • CT86 3 4
  • MIS18 Kinetochore Protein Homolog B (S. Pombe) 2
  • MIS18 Kinetochore Protein Homolog B 3
  • LAP2alpha Interactor-25 3
  • Protein Mis18-Beta 3
  • 5730547N13Rik 3
  • HMIS18beta 3
  • MIS18beta 3
  • LINT-25 3

External Ids for OIP5 Gene

Previous GeneCards Identifiers for OIP5 Gene

  • GC15M036969
  • GC15M034497
  • GC15M039180
  • GC15M039317
  • GC15M039389
  • GC15M041601
  • GC15M018455

Summaries for OIP5 Gene

GeneCards Summary for OIP5 Gene

OIP5 (Opa Interacting Protein 5) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Packaging Of Telomere Ends.

UniProtKB/Swiss-Prot for OIP5 Gene

  • Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OIP5 Gene

Genomics for OIP5 Gene

Regulatory Elements for OIP5 Gene

Genomic Location for OIP5 Gene

41,309,268 bp from pter
41,332,621 bp from pter
23,354 bases
Minus strand

Genomic View for OIP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OIP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OIP5 Gene

Proteins for OIP5 Gene

  • Protein details for OIP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Mis18-beta
    Protein Accession:
    Secondary Accessions:
    • Q96BX7

    Protein attributes for OIP5 Gene

    229 amino acids
    Molecular mass:
    24691 Da
    Quaternary structure:
    • Homodimer, and heterodimer with MIS18A. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4. Binds outer membrane protein OpaP from Neisseria gonorrhoeae.
    • Sequence=AAC39561.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OIP5 Gene

Proteomics data for OIP5 Gene at MOPED

Post-translational modifications for OIP5 Gene

  • Ubiquitination at Lys215 and Lys226
  • Modification sites at PhosphoSitePlus

Other Protein References for OIP5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OIP5 Gene

Domains for OIP5 Gene

Protein Domains for OIP5 Gene


Suggested Antigen Peptide Sequences for OIP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OIP5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OIP5 Gene

Function for OIP5 Gene

Molecular function for OIP5 Gene

UniProtKB/Swiss-Prot Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Gene Ontology (GO) - Molecular Function for OIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12620389
genes like me logo Genes that share ontologies with OIP5: view

Phenotypes for OIP5 Gene

GenomeRNAi human phenotypes for OIP5:
genes like me logo Genes that share phenotypes with OIP5: view

miRNA for OIP5 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OIP5 Gene

Localization for OIP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OIP5 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

Subcellular locations from

Jensen Localization Image for OIP5 Gene COMPARTMENTS Subcellular localization image for OIP5 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000785 chromatin IDA 17284516
GO:0005634 nucleus IDA 17284516
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with OIP5: view

Pathways for OIP5 Gene

genes like me logo Genes that share pathways with OIP5: view

Gene Ontology (GO) - Biological Process for OIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007154 cell communication NAS 9466265
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with OIP5: view

Transcripts for OIP5 Gene

mRNA/cDNA for OIP5 Gene

(51) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OIP5 Gene

Opa interacting protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OIP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for OIP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OIP5 Gene

mRNA expression in normal human tissues for OIP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OIP5 Gene

This gene is overexpressed in Testis (11.7) and Muscle - Skeletal (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OIP5 Gene

SOURCE GeneReport for Unigene cluster for OIP5 Gene Hs.661645

genes like me logo Genes that share expressions with OIP5: view

No data available for mRNA Expression by UniProt/SwissProt for OIP5 Gene

Orthologs for OIP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OIP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OIP5 35
  • 99.42 (n)
  • 98.69 (a)
OIP5 36
  • 99 (a)
(Bos Taurus)
Mammalia OIP5 35
  • 86.32 (n)
  • 82.1 (a)
OIP5 36
  • 76 (a)
(Canis familiaris)
Mammalia OIP5 35
  • 86.03 (n)
  • 82.53 (a)
OIP5 36
  • 82 (a)
(Mus musculus)
Mammalia Oip5 35
  • 80.13 (n)
  • 71.72 (a)
Oip5 16
Oip5 36
  • 62 (a)
(Monodelphis domestica)
Mammalia OIP5 36
  • 26 (a)
(Ornithorhynchus anatinus)
Mammalia OIP5 36
  • 36 (a)
(Gallus gallus)
Aves OIP5 35
  • 57 (n)
  • 46.15 (a)
OIP5 36
  • 37 (a)
(Danio rerio)
Actinopterygii oip5 36
  • 27 (a)
Species with no ortholog for OIP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OIP5 Gene

Gene Tree for OIP5 (if available)
Gene Tree for OIP5 (if available)

Paralogs for OIP5 Gene Pseudogenes for OIP5 Gene

genes like me logo Genes that share paralogs with OIP5: view

No data available for Paralogs for OIP5 Gene

Variants for OIP5 Gene

Sequence variations from dbSNP and Humsavar for OIP5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs6493000 -- 41,320,902(+) cccat(C/G)gtctg intron-variant
rs7161772 -- 41,318,868(+) ttttt(A/T)aaatt intron-variant
rs7163989 -- 41,322,423(+) agaca(A/G)gttct intron-variant
rs7165675 -- 41,322,506(+) tgatc(C/T)acctg intron-variant
rs7168307 -- 41,328,336(+) agatg(A/G)aacaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OIP5 Gene

Variant ID Type Subtype PubMed ID
esv25344 CNV Gain 19812545
esv2749606 CNV Deletion 23290073
esv2667320 CNV Deletion 23128226
esv2661625 CNV Deletion 23128226

Relevant External Links for OIP5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OIP5 Gene

Disorders for OIP5 Gene

No disorders were found for OIP5 Gene.

No data available for UniProtKB/Swiss-Prot for OIP5 Gene

Publications for OIP5 Gene

  1. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. (PMID: 17199038) Fujita Y. … Yanagida M. (Dev. Cell 2007) 2 3 4
  2. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. (PMID: 9466265) Williams J.M. … Rest R.F. (Mol. Microbiol. 1998) 2 3 4
  3. OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers. (PMID: 20510019) Chun H.K. … Lee H.G. (BMB Rep 2010) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Opa interacting protein 5 (OIP5) is a novel cancer-testis specific gene in gastric cancer. (PMID: 17151793) Nakamura Y. … Mori M. (Ann. Surg. Oncol. 2007) 23

Products for OIP5 Gene

Sources for OIP5 Gene

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