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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OIP5 Gene

protein-coding   GIFtS: 50
GCID: GC15M041601

Opa interacting protein 5
 Explore 1 disease affiliated with
OIP5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OIP5    

Aliases
for OIP5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Opa Interacting Protein 51 2     5730547N13Rik2
CT861 2 3     LINT-252
MIS18B1 2 3     MIS18beta2
HMIS18beta1     LAP2alpha Interactor-252
Cancer/Testis Antigen 862 3     MIS18 Kinetochore Protein Homolog B2
Opa-Interacting Protein 52 3     Protein Mis18-Beta2
OIP-52 3     

External Ids:    HGNC: 203001   Entrez Gene: 113392   Ensembl: ENSG000001041477   OMIM: 6060205   UniProtKB: O434823   

Export aliases for OIP5 gene to outside databases

Previous GC identifers: GC15M036969 GC15M034497 GC15M039180 GC15M039317 GC15M039389 GC15M018455


Summaries
for OIP5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MS18B_HUMAN, O43482
Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis




Genomic Views
for OIP5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OIP5 gene promoter:
         Bach1   Pax-5   Bach2   MyoD   AREB6   Cart-1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OIP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for OIP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OIP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14

OIP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OIP5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M041601:  view genomic region     (about GC identifiers)

Start:
 41,601,466 bp from pter      End:
 41,624,819 bp from pter
Size:
 23,354 bases      Orientation:
 minus strand

Proteins
for OIP5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MS18B_HUMAN, O43482 (See protein sequence)
Recommended Name: Protein Mis18-beta  
Size: 229 amino acids; 24691 Da
Subunit: Homodimer, and heterodimer with MIS18A. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and
RBBP4. Binds outer membrane protein OpaP from Neisseria gonorrhoeae
Subcellular location: Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase
cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated
with chromatin
Sequence caution: Sequence=AAC39561.1; Type=Erroneous initiation;
Secondary accessions: Q96BX7

Explore the universe of human proteins at neXtProt for OIP5: NX_O43482

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43482

    • OIP5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009211.1  
    ENSEMBL proteins: 
     ENSP00000220514   ENSP00000452851  
    Reactome Protein details: O43482
    Human Recombinant Protein Products: 
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    Novus Biologicals OIP5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OIP5

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000785chromatin IDA17284516
    GO:0005634nucleus IDA17284516
    GO:0005654nucleoplasm TAS--
    GO:0010369chromocenter IEA--


    OIP5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for OIP5

    Protein Domains /
    Families
    for OIP5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O43482


    Function
    for OIP5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MS18B_HUMAN, O43482
    Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OIP5
    1 QIAGEN miScript miRNA Assays for microRNA that regulate OIP5:
    hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: OIP5 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for OIP5

    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12620389


    OIP5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for OIP5:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for OIP5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RSF Complex Binds the Centromere.
    		RSF Complex Binds the Centromere.1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere1.00
    		Nucleosome assembly1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere.0.96
    2Cell Cycle
    		Cell Cycle1.00
    3Meiotic Synapsis
    		Chromosome Maintenance0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for OIP5 (see all 6)
        Deposition of New CENPA-containing Nucleosomes at the Centromere.
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Deposition of New CENPA-containing Nucleosomes at the Centromere



    OIP5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OIP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for OIP5 (O434821, 3 ENSP000002205144) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAF1P040491, 3, ENSP000002518494EBI-536879,EBI-365996 I2D: score=5 STRING: ENSP00000251849
    MIS18AQ9NYP93, ENSP000002901304I2D: score=1 STRING: ENSP00000290130
    BRAFP150563, ENSP000002886024I2D: score=4 STRING: ENSP00000288602
    CASC5ENSP000003354634STRING: ENSP00000335463
    CENPAENSP000003368684STRING: ENSP00000336868
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly TAS--
    GO:0007067mitosis IEA--
    GO:0007154cell communication NAS9466265
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS--
    GO:0051301cell division IEA--


    OIP5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for OIP5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OIP5
    Search CenterWatch for drugs/clinical trials and news about OIP5 / MS18B 

    Transcripts
    for OIP5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OIP5 gene: 
    NM_007280.1  

    Unigene Cluster for OIP5:

    Opa interacting protein 5
    Hs.661645  [show with all ESTs]
    Unigene Representative Sequence: BQ218042
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220514(uc001znp.3) ENST00000560640

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate OIP5:
    hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: OIP5 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF025441.1 BC015050.1 

    4 DOTS entries:

    DT.111704  DT.121040770  DT.306624  DT.95279554 

    24/51 AceView cDNA sequences (see all 51):

    BU620714 BM762104 BE048189 BG503804 AI953118 BE778254 NM_007280 CR603974 
    BQ651609 AA767724 AF025441 BC015050 BM784603 CB157707 AI191782 AA743696 
    BM848631 AA694578 BG772494 BU601314 BG498569 AI394114 BU633371 AF086478 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for OIP5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                    -                     


    ECgene alternative splicing isoforms for OIP5

    Expression
    for OIP5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OIP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCAGTTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    OIP5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)

    See OIP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OIP5

    SOURCE GeneReport for Unigene cluster: Hs.661645
        SABiosciences Custom PCR Arrays for OIP5
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    In Situ
    Assay Products:     
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    Orthologs
    for OIP5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for OIP5 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Oip51 , 5 Opa interacting protein 51, 5 80.13(n)1
    71.72(a)1    		   2 (59.97 cM)5
    706451  NM_001042653.11  NP_001036118.11 
     1196095125 
    chicken
    (Gallus gallus)    		 Aves OIP51 Opa interacting protein 5 57.43(n)
    46.99(a)    		   423212  NM_001199658.1  NP_001186587.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii oip56
    		 opa interacting protein 5
    		 26(a)
    		 1 ↔ 1
    		 13(33480449-33483401)


    ENSEMBL Gene Tree for OIP5 (if available)
    TreeFam Gene Tree for OIP5 (if available) 

    Paralogs
    for OIP5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OIP5 gene

    OIP5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OIP5
    PGOHUM00000241696


    Genomic Variants
    for OIP5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/437 NCBI SNPs in OIP5 are shown (see all 437)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1128271931,2
    		--41601044(+) GGTGCG/ACACCA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1914658951,2
    		--41601105(+) TTGGCA/GAGGCT 1 -- int10--------
    rs1505780441,2
    		--41601127(+) CCTGAC/TCTCAA 1 -- int10--------
    rs781627421,2
    		F,--41601148(+) GCCTCG/AGCCTC 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1396322701,2
    		--41601162(+) AAATCC/TGGAAT 1 -- int10--------
    rs1829630811,2
    		--41601186(+) CACTGC/TGCCAG 1 -- int10--------
    rs1871646421,2
    		--41601274(+) GTCTAA/TTTTTG 1 -- int10--------
    rs1914951701,2
    		--41601406(+) GTTTCA/GTTTTA 1 -- int10--------
    rs1417132281,2
    		--41601446(+) TCAGTC/TTACAA 1 -- int10--------
    rs1835230741,2
    		--41601551(+) TATTAA/GTATTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OIP5 (41601466 - 41624819 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for OIP5
         1 CNV: 66776

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    Disorders / Diseases
    for OIP5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OIP5 for disorders           About GeneDecksing

    OMIM gene information: 606020    OMIM disorders: --

    1 disease for OIP5:    About MalaCards
    gastric cancer


    Export disorders for OIP5 gene to outside databases

    Publications
    for OIP5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OIP5 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with OIP5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. (PubMed id 17199038)1, 2, 3 Fujita Y....Yanagida M. (2007)
    2. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. (PubMed id 9466265)1, 2, 3 Williams J.M.... Rest R.F. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. OIP5 is a highly expressed potential therapeutic targ et for colorectal and gastric cancers. (PubMed id 20510019)1, 9 Chun H.K....Lee H.G. (2010)
    5. Characterization of an Opa interacting protein 5 invol ved in lung and esophageal carcinogenesis. (PubMed id 22129094)1 Koinuma J....Daigo Y. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    External Searches for OIP5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing OIP5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11339 HGNC: 20300 AceView: OIP5 Ensembl:ENSG00000104147 euGenes: HUgn11339
    ECgene: OIP5 H-InvDB: OIP5

    Other Databases showing OIP5 gene

    (According to HUGE)
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    Specialized Databases showing OIP5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OIP5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for OIP5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OIP5 gene:
    Search GeneIP for patents involving OIP5

    GeneCards and IP:
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