OGT Gene
protein-coding GIFtS : 63 GCID: GC0X P070752
O-linked N-acetylglucosamine (GlcNAc) transferase O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl...
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Aliasesfor OGT gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases O-Linked N-Acetylglucosamine (GlcNAc) Transferase 1 2 O-GlcNAc Transferase P110 Subunit2 HRNT11 2 UDP-N-Acetylglucosamine--Peptide N-Acetylglucosaminyltransferase 110 KDaSubunit2 O-GLCNAC1 2 UDP-N-Acetylglucosamine:Polypeptide-N-Acetylglucosaminyl Transferase2 O-Linked N-Acetylglucosamine (GlcNAc) Transferase(UDP-N-Acetylglucosamine:Polypeptide-N-Acetylglucosaminyl Transferase)1 2 Uridinediphospho-N-Acetylglucosamine:Polypeptide Beta-N-AcetylglucosaminylTransferase2 O-GlcNAc Transferase Subunit P1102 3 EC 2.4.1.2553 O-Linked N-Acetylglucosamine Transferase 110 KDa Subunit2 3 EC 2.4.18 FLJ230711 EC 2.4.1.1868 MGC229211
Export aliases for OGT gene to outside databases Previous GC identifers: GC0XP066927 GC0XP068231 GC0XP068986 GC0XP069619 GC0XP070535 GC0XP070669 GC0XP064568
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Summariesfor OGT gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for OGT : This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Oct 2009) UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294 Function : Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue incytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues Function : Isoform 2, the mitochondrial isoform (mOGT), is cytotoxic and triggers apoptosis in several cell typesincluding INS1, an insulinoma cell line Gene Wiki entry for OGT
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Genomic Viewsfor OGT gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011669.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OGT gene promoter:AP-1 CUTL1 Other transcription factors Search SABiosciences Chromatin IP Primers for OGT Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OGT
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq13 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13 OGT Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP070752: view genomic region
(about GC identifiers )
Start: 70,752,912 bp from pter End:
70,795,747 bp from pter
Size: 42,836 bases Orientation:
plus strand
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Proteinsfor OGT gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294 See
protein sequence )Recommended Name: Size : 1046 amino acids; 116925 DaSubunit : Heterotrimer; consists of one 78 kDa subunit and two 110 kDa subunits dimerized via TPR repeats 6 and 7.Interacts (via TPR repeats 6 and 7) with ATXN10 (By similarity). Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, HCFC1, PPP1CC and ACTB. Component of a THAP1/THAP3-HCFC1-OGT complex. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts directly with HCFC1; the interaction O-glycosylates HCFC1, regulates its proteolytic processing and transcriptional activity and, in turn, stabilizes OGT in the nucleus. Interacts (via TPRs 1-6) with SIN3A; the interaction mediates transcriptional repression in parallel with histone deacetylase
Subcellular location : Isoform 2: Mitochondrion. Membrane. Note=Associates with the mitochondrial inner membraneSubcellular location : Isoform 3: Cytoplasm. Nucleus. Cell membrane. Note=Mostly in the nucleus. Retained in the nucleusvia interaction with HCFC1. After insulin induction, translocated from the nucleus to the cell membrane via phophatidylinisotide binding. Colocalizes with AKT1 at the plasma membrane
Subcellular location : Isoform 4: Cytoplasm. Nucleus6/11 PDB 3D structures from (see all 11 ):1W3B (3D) 3PE3 (3D) 3PE4 (3D) 3TAX (3D) 4AY5 (3D) 4AY6 (3D) Secondary accessions : Q7Z3K0 Q8WWM8 Q96CC1 Q9UG57Alternative splicing : 4 isoforms : O15294-1 O15294-2 O15294-3 O15294-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for OGT: NX_O15294 Post-translational modifications:
Ubiquitinated, leading to its proteasomal degradation1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O15294 4/30 DME Specific Peptides for OGT (O15294 ) (see all 30 )OGT Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_858058.1 NP_858059.1 ENSEMBL proteins: ENSP00000362824 ENSP00000362805 ENSP00000399729 ENSP00000407659 Human Recombinant Protein Products: Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8 ): About this table
About GeneDecksing OGT Antibody Products: Assay Products for OGT:
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Protein
Domains /for OGT gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O15294 ProtoNet protein and cluster: O15294
UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294 Domain : The TPR repeat domain is required for substrate binding and oligomerizationSimilarity : Belongs to the O-GlcNAc transferase familySimilarity : Contains 13 TPR repeats
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Functionfor OGT gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294 Function : Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue incytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues Function : Isoform 2, the mitochondrial isoform (mOGT), is cytotoxic and triggers apoptosis in several cell typesincluding INS1, an insulinoma cell line Catalytic activity : UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP +[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine Catalytic activity : UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP +[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine Enzyme regulation : Subject to product inhibition by UDPBiophysicochemical properties : Kinetic parameters: KM=1.8 uM for UDP-N-acetyl-D-glucosamine;Induction : Induction of the nucleocytoplasmic OGT (ncOGT) isoform in the liver on glucose deprivation is mediated bythe decreased hexosamine biosynthesis pathway (HBP) flux
Genatlas biochemistry entry for OGT O-linked N-acetylglucosamine (GlcNAc) transferase,putative part of a glucose-responsive pathway implicated in the pathogenesis of diabetes mellitus Enzyme Numbers (IUBMB): EC 2.4.1 2 EC 2.4.1.255 1 EC 2.4.1.186 2 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): OGT (NM_181672 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OGT Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OGT
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGT
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10 ): About this table
About GeneDecksing Animal Models: 8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ogt) :About GeneDecksing
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Pathways & Interactionsfor OGT gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Glucose / Energy Metabolism 2 Glucuronidation
Pathway sources See GeneCards unified pathways Show all pathways 1 1 (Kegg details for OGT) :UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294 Pathway : Protein modification; protein glycosylationAbout GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OGT STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/52 Interacting proteins for OGT (O15294 1 , 2 , 3 ENSP00000362824 4 via UniProtKB, MINT, STRING , and/or I2D (see all 52 )
Interactant Interaction Details GeneCard External ID(s) NFATC1 O95644 2 , 3 ENSP00000327850 4 MINT-6167028 MINT-6166975 I2D:
score=1 STRING: ENSP00000327850 HCFC1 P51610 1 , 3 ENSP00000309555 4 EBI-539828,EBI-2832627 I2D:
score=4 STRING: ENSP00000309555 FOXO4 P98177 2 , 3 ENSP00000363377 4 MINT-7299691 I2D:
score=1 STRING: ENSP00000363377 RELA Q04206 2 , 3 ENSP00000384273 4 MINT-6167028 MINT-6166971 I2D:
score=1 STRING: ENSP00000384273 NUP62CL Q9H1M0 3 ENSP00000361544 4 I2D:
score=4 STRING: ENSP00000361544
About this table Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19 ): About this table
About GeneDecksing
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Drugs & Compoundsfor OGT gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for OGT 5 HMDB Compounds for OGT About this table 8 Novoseek chemical compound relationships for OGT gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
n-acetylglucosamine
84.4
14
12504895 (1), 16382487 (1), 11554736 (1), 14749383 (1) (see all 13 )
udp-n-acetylglucosamine
66.4
2
15305040 (1), 12373287 (1)
threonine
57
6
16382487 (1), 14749383 (1), 12373287 (1), 18519567 (1) (see all 6 )
alloxan
46.8
2
12373287 (1)
serine
44.7
6
16382487 (1), 14749383 (1), 12373287 (1), 18519567 (1) (see all 6 )
streptozotocin
38.4
3
12373287 (1), 9917327 (1)
tyrosine
23.3
12
18519567 (2), 19238206 (2), 9083067 (1), 15147958 (1)
glucose
18.3
15
18353774 (5), 18174169 (3), 20190804 (1), 12373287 (1) (see all 5 )
OGT / OGT1
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Transcriptsfor OGT gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for OGT gene (3 alternative transcripts): NM_181672.2 NM_181673.2 NM_003605.3 Unigene Cluster for OGT:
O-linked N-acetylglucosamine (GlcNAc) transferase Hs.405410 [show with all ESTs ] Unigene Representative Sequence: AL050366 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000373719 (uc004eaa.2 uc004eab.2 uc004eac.3 uc004ead.3 )ENST00000488174 (uc011mpw.2 ) ENST00000373701 ENST00000472270 ENST00000498566 ENST00000444774 ENST00000455587 ENST00000459760 ENST00000462638 ENST00000466181 ENST00000474633 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): OGT (NM_181672 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OGT Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OGT
Additional cDNA sequence: AF070560.1 AF147394.1 AF223393.1 AK300267.1 AK313530.1 AL049950.1 AL050366.1 AL833085.2 BC014434.1 BC015144.1 BC038180.1 BX537844.1 U77413.1
24 DOTS entries : DT.91967229 DT.99931287
DT.100822668 DT.95252610 DT.452005 DT.101958541 DT.100822669 DT.121302034 DT.95252653 DT.95252613 DT.102833716 DT.121302019 DT.95252611 DT.95252639 DT.95252651 DT.95363744 DT.100729590 DT.100748147 DT.102833715 DT.121301968 DT.121301976 DT.40288541 DT.40317290 DT.91926349 24/422 AceView cDNA sequences (see all 422 ):
BP366743 F12104 BC014434 CA447100 AU133528 N34584 BM873850 BP360404 AI382024 AA253130 AA417573 N36742 AA278681 CA415065 BM874712 AL050366 F09742 AA974846 AI984704 BF001665 AI339703 CA450009 AA515119 AW948847 GeneLoc Exon Structure 5/13 Alternative Splicing Database (ASD) splice patterns (SP) for OGT (see all 13 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ SP1 : - - - - - - - SP2 : - - - - - - - - SP3 : SP4 : - SP5 : - - - - - - - - - - - - - -
ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26 SP1 : - - SP2 : - - SP3 : - - SP4 : - - SP5 :
ECgene alternative splicing isoforms for OGT
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Expression for OGT gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section OGT expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTTGCAGATA
About this image OGT expression in embryonic tissues and stem cells About this table 1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Bone Mandibular Fossa Bone Expression: Experimental details:
In-situ hybridization
See OGT Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OGT SOURCE GeneReport for Unigene cluster: Hs.405410 UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294 Tissue specificity : Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta.Present in trace amounts in lung and liver SABiosciences Expression via Pathway-Focused PCR Array including OGT : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGT
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Orthologsfor OGT gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for OGT gene from 8/28 species (see all 28 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves OGT1
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl more
83.99(n) 97.58(a)
422203 XM_001232518.2 XP_001232519.1
lizard Reptilia OGT6
--
97(a)
1 ↔ 1
GL343599.1(4082-18929)
African clawed frog Amphibia Xl.259362
Xenopus laevis transcribed sequence with strong similarity more
83.03(n)
CF549038.1
zebrafish Actinopterygii wufr75f092
wufr75f09
76.13(n)
386953 CF265884.1
fruit fly Insecta Ogt3 1
transferase, transferring glycosyl groups3 1
58(a) 3 67.43(n) 1 78(a) 1
41F23 35486 1 NM_078896.2 1 NP_523620.1 1
worm Secernentea K04G7.33 1
Protein OGT-11
68(a) 3 63.69(n) 1 69.08(a) 1
III(7218216-7225517)3 176000 1 NM_001047395.2 1 NP_001040860.1 1
thale cress eudicotyledons SEC1
putative UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase more
52.35(n) 46.33(a)
819579 NM_111295.3 NP_187074.1
rice Liliopsida Os.459682
Oryza sativa (japonica cultivar-group) putative O-linked more
75.13(n)
NM_189933.1
ENSEMBL Gene Tree for OGT (if available)TreeFam Gene Tree for OGT (if available)
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Paralogsfor OGT gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for OGT gene TMTC3 2 TMTC2 2 TMTC1 2 TMTC4 2 About GeneDecksing
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Genomic Variantsfor OGT gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr X pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for OGT (70752912 - 70795747 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for OGT 1 CNV 7797 Locus Specific Mutation Databases (LSDB): OGT
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor OGT gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 300255
OMIM disorders : --UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294 Note=Regulation of OGT activity and altered O-GlcNAcylations are implicated in diabetes and Alzheimer disease. O-GlcNAcylation of AKT1 affects insulin signaling and, possibly diabetes. Reduced O-GlcNAcylations and resulting increased phosphorylations of MAPT/TAU are observed in Alzheimer disease (AD) brain cerebrum 13 : About MalaCards insulin resistance neurodegenerative disease diabetes mellitus alzheimer's disease insulinoma hyperglycemia ovarian cancer pancreatic cancer breast cancer pancreatitis immunodeficiency hepatitis neuronitis 2 diseases from the University of Copenhagen DISEASES database for OGT :Diabetes mellitus Hyperglycemia 4 Novoseek disease relationships for OGT gene About this table
Human Genome Epidemiology (HuGE) Navigator: OGT (3 documents) Export disorders for OGT gene to outside databases
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Publicationsfor OGT gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for OGT gene, integrated from 9 sources (see all 149 ):(articles sorted by number of sources associating them with OGT) Utopia : connect your pdf to the dynamic
O-linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. (PubMed id 9083068) 1 , 2 , 3(1997) Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. (PubMed id 18288188) 1 , 2 , 9(2008) Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. (PubMed id 12150998) 1 , 2 , 9(2002) The THAP-zinc finger protein THAP1 associates with co activator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonia s. (PubMed id 20200153) 1 , 2 , 9(2010) Human O-GlcNAc transferase (OGT): genomic structure, analysis of splice variants, fine mapping in Xq13.1. (PubMed id 11773972) 1 , 2 , 9(2002) Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway. (PubMed id 21285374) 1 , 2 (2011) Structure of human O-GlcNAc transferase and its complex with a peptide substrate. (PubMed id 21240259) 1 , 2 (2011) Elevated O-GlcNAc-dependent signaling through inducib le mOGT expression selectively triggers apoptosis. (PubMed id 20824293) 1 , 2 (2011) Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux. (PubMed id 19073609) 1 , 2 (2009) GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. (PubMed id 19377461) 1 , 2 (2009)
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External Searches for OGT gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing OGT gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing OGT gene
(According to HUGE )
About This Section --
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Specialized Databases showing OGT gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for OGT Pharmacogenomics, SNPs, Pathways Functional Glycomics Gateway - GTase http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_554
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About This Section Patent Information for OGT gene: OGT GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor OGT gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for OGT OriGene shRNA RFP for OGT OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for OGT Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for OGT OriGene 3'-UTR Clone for OGT OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for OGT OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for OGT OriGene Custom Protein Services for OGT OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OGT QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OGT QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for OGT
Search Tocris compounds for OGT
OGT Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGT
ThermoFisher Antibody for OGT
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OGT
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and Proteopedia 
for OGT (
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
In-situ hybridization
