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OGT Gene

protein-coding   GIFtS: 66
GCID: GC0XP070752

O-Linked N-Acetylglucosamine (GlcNAc) Transferase

(Previous name: O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
O-Linked N-Acetylglucosamine (GlcNAc) Transferase1 2     O-GlcNAc Transferase P110 Subunit2
O-Linked N-Acetylglucosamine (GlcNAc) Transferase
(UDP-N-Acetylglucosamine:Polypeptide-N-Acetylglucosaminyl Transferase)1 2
     UDP-N-Acetylglucosamine--Peptide N-Acetylglucosaminyltransferase 110 KDa
Subunit2
UDP-N-Acetylglucosamine:Polypeptide-N-Acetylglucosaminyl Transferase1 2     Uridinediphospho-N-Acetylglucosamine:Polypeptide Beta-N-Acetylglucosaminyl
Transferase2
O-GlcNAc Transferase Subunit P1102 3     EC 2.4.1.2553
O-Linked N-Acetylglucosamine Transferase 110 KDa Subunit2 3     EC 2.4.18
HRNT12     EC 2.4.1.1868
O-GLCNAC2     

External Ids:    HGNC: 81271   Entrez Gene: 84732   Ensembl: ENSG000001471627   OMIM: 3002555   UniProtKB: O152943   

Export aliases for OGT gene to outside databases

Previous GC identifers: GC0XP066927 GC0XP068231 GC0XP068986 GC0XP069619 GC0XP070535 GC0XP070669 GC0XP064568


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OGT Gene:
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in
O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for
similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate
specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide
repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants
encoding distinct isoforms have been found for this gene. (provided by RefSeq, Oct 2009)

GeneCards Summary for OGT Gene:
OGT (O-linked N-acetylglucosamine (GlcNAc) transferase) is a protein-coding gene. Diseases associated with OGT include insulin resistance, and insulinoma. GO annotations related to this gene include enzyme activator activity and acetylglucosaminyltransferase activity. An important paralog of this gene is TMTC3.

UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294
Function: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue
in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine
(O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, KMT2E/MLL5,
MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and
phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte
cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1,
enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating
glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT
complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in
chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription
start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3). As part of the NSL
complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues
Function: Isoform 2: the mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types
including INS1, an insulinoma cell line

Gene Wiki entry for OGT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OGT gene promoter:
         AP-1   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOGT promoter sequence
   Search Chromatin IP Primers for OGT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OGT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13

OGT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OGT gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP070752:  view genomic region     (about GC identifiers)

Start:
70,752,912 bp from pter      End:
70,795,747 bp from pter
Size:
42,836 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294 (See protein sequence)
Recommended Name: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit  
Size: 1046 amino acids; 116925 Da
Subunit: Heterotrimer; consists of one 78 kDa subunit and two 110 kDa subunits dimerized via TPR repeats 6 and 7.
Interacts (via TPR repeats 6 and 7) with ATXN10 (By similarity). Component of the MLL5-L complex, at least
composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, HCFC1, PPP1CC and ACTB. Component of a THAP1/THAP3-HCFC1-OGT
complex. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20,
OGT1/OGT, WDR5 and HCFC1. Interacts directly with HCFC1; the interaction O-glycosylates HCFC1, regulates its
proteolytic processing and transcriptional activity and, in turn, stabilizes OGT in the nucleus. Interacts (via
TPRs 1-6) with SIN3A; the interaction mediates transcriptional repression in parallel with histone deacetylase.
Interacts (via TPR 5-6) with TET1, TET2 and TET3
Selected PDB 3D structures from and Proteopedia for OGT (see all 16):
1W3B (3D)        3PE3 (3D)        3PE4 (3D)        3TAX (3D)        4AY5 (3D)        4AY6 (3D)    
Secondary accessions: Q7Z3K0 Q8WWM8 Q96CC1 Q9UG57
Alternative splicing: 4 isoforms:  O15294-1   O15294-2   O15294-3   O15294-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OGT: NX_O15294

Explore proteomics data for OGT at MOPED

Post-translational modifications: 

  • Ubiquitinated, leading to its proteasomal degradation1
  • Ubiquitination2 at Lys16, Lys83, Lys100, Lys168, Lys337, Lys644, Lys724, Lys742, Lys971, Lys1010
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for OGT (O15294) (see all 30)
     LWLLRFP  NTGVLLL  NLGNVYK  QDGIHIL 


    See OGT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_858058.1  NP_858059.1  

    ENSEMBL proteins: 
     ENSP00000362824   ENSP00000362805   ENSP00000399729   ENSP00000407659  
    Reactome Protein details: O15294

    OGT Human Recombinant Protein Products:

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    Novus Biologicals OGT Protein
    Novus Biologicals OGT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OGT

    OGT Antibody Products:

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    Cell Signaling Technology (CST) Antibodies for OGT 
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    Novus Biologicals OGT Antibodies
    Abcam antibodies for OGT
    Cloud-Clone Corp. Antibodies for OGT
    ThermoFisher Antibody for OGT
    LSBio Antibodies in human, mouse, rat for OGT

    OGT Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OGT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OGT
    Cloud-Clone Corp. CLIAs for OGT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001440 TPR_1
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry O15294

    ProtoNet protein and cluster: O15294

    UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294
    Domain: The TPR repeat domain is required for substrate binding and oligomerization
    Similarity: Belongs to the O-GlcNAc transferase family
    Similarity: Contains 13 TPR repeats


    OGT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OGT1_HUMAN, O15294
    Function: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue
    in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine
    (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, KMT2E/MLL5,
    MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and
    phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte
    cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1,
    enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating
    glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT
    complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in
    chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription
    start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3). As part of the NSL
    complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues
    Function: Isoform 2: the mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types
    including INS1, an insulinoma cell line
    Catalytic activity: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP +
    [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine
    Catalytic activity: UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP +
    [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine
    Enzyme regulation: Subject to product inhibition by UDP
    Biophysicochemical properties: Kinetic parameters: KM=1.8 uM for UDP-N-acetyl-D-glucosamine;
    Induction: Induction of the nucleocytoplasmic OGT (ncOGT) isoform in the liver on glucose deprivation is mediated
    by the decreased hexosamine biosynthesis pathway (HBP) flux

         Genatlas biochemistry entry for OGT:
    O-linked N-acetylglucosamine (GlcNAc) transferase,putative part of a glucose-responsive pathway implicated in the
    pathogenesis of diabetes mellitus

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.2551 EC 2.4.1.1862

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12150998
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA18288188
    GO:0008047enzyme activator activity IDA--
    GO:0008375acetylglucosaminyltransferase activity TAS9083068
    GO:0016262protein N-acetylglucosaminyltransferase activity IDA--
         
    OGT for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ogt):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  immune system 
     mortality/aging  normal  reproductive system 

    OGT for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OGT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OGT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OGT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OGT

    miRNA
    Products:
        
    miRTarBase miRNAs that target OGT:
    hsa-mir-26a-5p (MIRT050178), hsa-mir-671-5p (MIRT039274), hsa-mir-125a-5p (MIRT045697), hsa-mir-92a-3p (MIRT049427)

    Block miRNA regulation of human, mouse, rat OGT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OGT (see all 68):
    hsa-miR-579 hsa-miR-140-5p hsa-miR-26a-2* hsa-miR-15a hsa-miR-200a hsa-miR-519a hsa-miR-502-3p hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidOGT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OGT
    Predesigned siRNA for gene silencing in human, mouse, rat OGT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OGT

    Clone
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    OriGene clones in human, mouse for OGT (see all 12)
    OriGene ORF clones in mouse, rat for OGT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): OGT (NM_181672)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OGT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGT

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for OGT 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OGT1_HUMAN, O15294: Isoform 2: Mitochondrion. Membrane. Note=Associates with the mitochondrial inner membrane
    OGT1_HUMAN, O15294: Isoform 3: Cytoplasm. Nucleus. Cell membrane. Note=Mostly in the nucleus. Retained in the
    nucleus via interaction with HCFC1. After insulin induction, translocated from the nucleus to the cell membrane
    via phophatidylinisotide binding. Colocalizes with AKT1 at the plasma membrane
    OGT1_HUMAN, O15294: Isoform 4: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion5
    nucleus5
    plasma membrane5
    cytoskeleton4
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IDA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    OGT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OGT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    2Other types of O-glycan biosynthesis
    Other types of O-glycan biosynthesis
    3Glucose / Energy Metabolism
    Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for OGT
        Glucose / Energy Metabolism

    1 Reactome Pathway for OGT
        HATs acetylate histones


    1 Kegg Pathway  (Kegg details for OGT):
        Other types of O-glycan biosynthesis

    UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294
    Pathway: Protein modification; protein glycosylation


    OGT for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including OGT: 

              Glycosylation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OGT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OGT (O152941, 2, 3 ENSP000003628244) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFATC1O956441, 2, 3, ENSP000003278504EBI-539828,EBI-6907210 MINT-6167028 MINT-6166975 I2D: score=1 STRING: ENSP00000327850
    HCFC1P516101, 3, ENSP000003095554EBI-539828,EBI-396176 I2D: score=4 STRING: ENSP00000309555
    FOXO4P981772, 3, ENSP000003633774MINT-7299691 I2D: score=1 STRING: ENSP00000363377
    ENSG00000206454Q018603, ENSP000003730164I2D: score=2 STRING: ENSP00000373016
    ENSG00000229094Q018603, ENSP000003888424I2D: score=2 STRING: ENSP00000388842
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006110regulation of glycolytic process IDA--
    GO:0006325chromatin organization TAS--
    GO:0006493protein O-linked glycosylation IMP--
    GO:0006915apoptotic process IDA--
    GO:0007165signal transduction TAS9083067

    OGT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OGT (OGT1)

    5 HMDB Compounds for OGT    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Lactosaminebeta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)13000-25-4--
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--

    8 Novoseek inferred chemical compound relationships for OGT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetylglucosamine 84.4 14 12504895 (1), 16382487 (1), 11554736 (1), 14749383 (1) (see all 13)
    udp-n-acetylglucosamine 66.4 2 15305040 (1), 12373287 (1)
    threonine 57 6 16382487 (1), 14749383 (1), 12373287 (1), 18519567 (1) (see all 6)
    alloxan 46.8 2 12373287 (1)
    serine 44.7 6 16382487 (1), 14749383 (1), 12373287 (1), 18519567 (1) (see all 6)
    streptozotocin 38.4 3 12373287 (1), 9917327 (1)
    tyrosine 23.3 12 18519567 (2), 19238206 (2), 9083067 (1), 15147958 (1)
    glucose 18.3 15 18353774 (5), 18174169 (3), 20190804 (1), 12373287 (1) (see all 5)



    OGT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for OGT gene (3 alternative transcripts): 
    NM_181672.2  NM_181673.2  NM_003605.3  

    Unigene Cluster for OGT:

    O-linked N-acetylglucosamine (GlcNAc) transferase
    Hs.405410  [show with all ESTs]
    Unigene Representative Sequence: AL050366
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373719(uc004eaa.2 uc004eab.2 uc004eac.3 uc004ead.3)
    ENST00000488174(uc011mpw.2) ENST00000373701 ENST00000472270 ENST00000498566
    ENST00000444774 ENST00000455587 ENST00000459760 ENST00000462638 ENST00000466181
    ENST00000474633

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    Selected qRT-PCR Assays for microRNAs that regulate OGT (see all 68):
    hsa-miR-579 hsa-miR-140-5p hsa-miR-26a-2* hsa-miR-15a hsa-miR-200a hsa-miR-519a hsa-miR-502-3p hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidOGT 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OGT
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    GenScript: all cDNA clones in your preferred vector (see all 2): OGT (NM_181672)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGT
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      QuantiFast Probe-based Assays in human, mouse, rat OGT

    Additional mRNA sequence: 

    AF070560.1 AF147394.1 AF223393.1 AK300267.1 AK313530.1 AL049950.1 AL050366.1 AL833085.2 
    BC014434.1 BC015144.1 BC038180.1 BX537844.1 U77413.1 

    Selected DOTS entries (see all 26):

    DT.91967229  DT.99931287  DT.100822668  DT.95252610  DT.452005  DT.100822669  DT.101958541  DT.121302034 
    DT.95252653  DT.95252613  DT.102833715  DT.102833716  DT.121302019  DT.95252611  DT.95252639  DT.95252651 
    DT.95363744  DT.100665946  DT.100729590  DT.100748147  DT.121301968  DT.121301976  DT.40288541  DT.40317290 

    Selected AceView cDNA sequences (see all 422):

    AI660100 AA890003 CB854762 AI383092 AI133430 BU684202 CA391079 BQ316752 
    AI886433 AI374897 AI581283 BU159751 CF456990 CA447100 AA708819 CA414520 
    CN482977 BM745054 T34554 BM874712 F09742 AI332788 AA515119 CA450009 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OGT (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
    SP1:                          -                 -     -                       -     -     -     -                                                               
    SP2:                          -     -           -     -                       -     -     -     -                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -                                             
    SP5:                          -     -     -     -     -     -     -     -     -     -     -     -     -           -                                             

    ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26
    SP1:                                            -           -                                       
    SP2:                                            -           -                                       
    SP3:                                            -           -                                       
    SP4:                                            -           -                                       
    SP5:                                                                                                


    ECgene alternative splicing isoforms for OGT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OGT expression in normal human tissues (normalized intensities)      OGT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGCAGATA
    OGT Expression
    About this image


    OGT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    OGT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OGT Protein Expression

    Genevestigator expression for OGT

    SOURCE GeneReport for Unigene cluster: Hs.405410

    UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294
    Tissue specificity: Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and
    placenta. Present in trace amounts in lung and liver

        Pathway & Disease-focused RT2 Profiler PCR Array including OGT: 
              Glycosylation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OGT gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ogt1 , 5 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl more1, 5 92.45(n)1
    99.62(a)1
      X (44.45 cM)5
    1081551  NM_139144.31  NP_631883.21 
     1016400605 
    chicken
    (Gallus gallus)
    Aves OGT1 O-linked N-acetylglucosamine (GlcNAc) transferase 83.99(n)
    97.58(a)
      422203  XM_001232518.3  XP_001232519.1 
    lizard
    (Anolis carolinensis)
    Reptilia OGT6
    O-linked N-acetylglucosamine (GlcNAc) transferase
    97(a)
    1 ↔ 1
    GL343599.1(825-25548)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.259362 Xenopus laevis transcribed sequence with strong similarity more 83.03(n)    CF549038.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufr75f092 wufr75f09 76.13(n)   386953  CF265884.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ogt3
    sxc1
    transferase, transferring glycosyl
    groups3
    super sex combs1
    58(a)3
    67.43(n)1
    78(a)1
      41F23
    354861  NM_165427.21  NP_724407.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K04G7.33
    ogt-11
    ogt-11 68(a)3
    63.54(n)1
    68.74(a)1
      III(7218216-7225517)3
    1760001  NM_001047395.31  NP_001040860.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SEC1 SEC 52.33(n)
    46.39(a)
      819579  NM_111295.3  NP_187074.1 
    rice
    (Oryza sativa)
    Liliopsida Os.459682 Oryza sativa (japonica cultivar-group) putative O-linked more 75.13(n)    NM_189933.1 


    ENSEMBL Gene Tree for OGT (if available)
    TreeFam Gene Tree for OGT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OGT gene
    TMTC32  TMTC22  TMTC12  TMTC42  

    OGT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for OGT (see all 473)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341278231,2
    C--70751063(+) CACAT-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.00CSA 2
    rs1904416201,2
    --70757482(+) AGTGGC/TGTTAC 2 -- us2k10--------
    rs1820888081,2
    --70757652(+) TCTCAC/GCCCCT 2 -- us2k10--------
    rs120080911,2
    C,F,H--70757769(+) AGGCTT/ACAGAT 2 -- us2k15Minor allele frequency- A:0.02NS EA NA 420
    rs1852120121,2
    --70757901(+) AAAGAA/GTTTTT 2 -- us2k10--------
    rs1143625701,2
    C--70758010(+) ACAGAG/TAGGGA 2 -- us2k10--------
    rs1896339831,2
    --70758190(+) TGTGCC/TATTTC 2 -- us2k10--------
    rs1812681371,2
    --70758311(+) CATTGA/GCCTGC 2 -- us2k10--------
    rs1853339551,2
    --70758534(+) TAGAGA/GCAATT 2 -- us2k10--------
    rs1497512371,2
    C--70759168(+) GTCCCG/TTGTGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for OGT (70752912 - 70795747 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OGT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740213CNV Deletion23290073
    esv33082CNV Loss17666407
    esv1584074OTHER Inversion17803354

    Locus Specific Mutation Databases (LSDB): OGT

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OGT
    DNA2.0 Custom Variant and Variant Library Synthesis for OGT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300255    OMIM disorders: --

    UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294
  • Note=Regulation of OGT activity and altered O-GlcNAcylations are implicated in diabetes and Alzheimer
    disease. O-GlcNAcylation of AKT1 affects insulin signaling and, possibly diabetes. Reduced O-GlcNAcylations and
    resulting increased phosphorylations of MAPT/TAU are observed in Alzheimer disease (AD) brain cerebrum

  • 20 diseases for OGT:    About MalaCards
    insulin resistance    insulinoma    labyrinthitis    hyperglycemia
    endometrial carcinoma    alzheimer's disease    diabetes mellitus    pancreatic cancer
    ovarian cancer    pancreatitis    prostate cancer    endotheliitis
    prostatitis    multiple myeloma    breast cancer    myeloma
    malaria    cerebritis    hepatitis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for OGT:
    Diabetes mellitus     Hyperglycemia

    OGT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for OGT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 35.1 3 16714295 (1), 19666537 (1), 12911634 (1)
    insulin resistance 23.9 2 18288188 (1), 10753899 (1)
    alzheimers disease 7.67 4 16714295 (1), 12911634 (1)
    cancer 0 2 20190804 (1), 19666537 (1)

    Genetic Association Database (GAD): OGT
    Human Genome Epidemiology (HuGE) Navigator: OGT (3 documents)

    Export disorders for OGT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for OGT gene, integrated from 10 sources (see all 166):
    (articles sorted by number of sources associating them with OGT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. O-linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. (PubMed id 9083068)1, 2, 3 Lubas W.A.... Hanover J.A. (J. Biol. Chem. 1997)
    2. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. (PubMed id 18288188)1, 2, 9 Yang X.... Evans R.M. (Nature 2008)
    3. Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. (PubMed id 12150998)1, 2, 9 Yang X.... Kudlow J.E. (Cell 2002)
    4. The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias. (PubMed id 20200153)1, 2, 9 Mazars R.... Girard J.P. (J. Biol. Chem. 2010)
    5. Human O-GlcNAc transferase (OGT): genomic structure, analysis of splice variants, fine mapping in Xq13.1. (PubMed id 11773972)1, 2, 9 Nolte D. and Muller U. (Mamm. Genome 2002)
    6. TET2 promotes histone O-GlcNAcylation during gene transcription. (PubMed id 23222540)1, 2 Chen Q.... Yu X. (Nature 2013)
    7. Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway. (PubMed id 21285374)1, 2 Daou S.... Affar E.B. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    8. Structure of human O-GlcNAc transferase and its complex with a peptide substrate. (PubMed id 21240259)1, 2 Lazarus M.B.... Walker S. (Nature 2011)
    9. Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis. (PubMed id 20824293)1, 2 Shin S.H.... Hanover J.A. (Amino Acids 2011)
    10. Glucose metabolism gene polymorphisms and clinical outcome in pancreatic cancer. (PubMed id 20845477)1, 4 Dong X....Li D. (Cancer 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 8473 HGNC: 8127 AceView: OGT Ensembl:ENSG00000147162 euGenes: HUgn8473
    ECgene: OGT Kegg: 8473 H-InvDB: OGT

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for OGT Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_554

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OGT gene:
    Search GeneIP for patents involving OGT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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