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OGT Gene

protein-coding GIFtS: 60

GC0XP070669

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.4.1.- ^³
FLJ23071 ^¹, ²
HRNT1 ^¹, ²
MGC22921 ^¹, ²
O-GLCNAC ^¹, ²
OTTHUMP00000032154 ^²
OTTHUMP00000032166 ^²

Descriptions
O-GlcNAc transferase p110 subunit ^²
O-GlcNAc transferase subunit p110 ^³
O-linked GlcNAc transferase ^²
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) ^²
O-linked N-acetylglucosamine transferase 110 kDa subunit ^³
uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase ^²

External Ids
HGNC: 8127¹
Entrez Gene: 8473²
UniProtKB: O15294³
Ensembl: ENSG00000147162⁷

Search outside databases for aliases for OGT gene

Previous GC identifers: GC0XP066927 GC0XP068231 GC0XP068986 GC0XP069619 GC0XP070535

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OGT:

O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single

N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both

phosphorylation and glycosylation compete for similar serine or threonine residues, the two

processes may compete for sites, or they may alter the substrate specificity of nearby sites by

steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a

putative bipartite nuclear localization signal. Two alternatively spliced transcript variants

encoding distinct isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294

Function: Addition of nucleotide-activated sugars directly onto the polypeptide through

O-glycosidic linkage with the hydroxyl of serine or threonine

Gene Wiki entry for OGT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OGT gene

Entrez Gene cytogenetic band: Xq13 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13

OGT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP070669: (about GC identifiers)

Start:	70,669,658 bp from pter
End:	70,712,465 bp from pter
Size:	42,808 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011669.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294 (See protein sequence)

Recommended Name: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Size: 1046 amino acids; 116925 Da

Subunit: Heterotrimer of two 110 kDa and one 70 kDa subunits. It is not known if the 70 kDa subunit

is encoded by a separate gene or is the product of either of a proteolytic degradation or an

alternative initiation of the 110 kDa subunit (By similarity). Interacts with HCFC1

Subcellular location: Cytoplasm (Potential). Nucleus (Potential)

PDB structures from and Proteopedia :

1W3B (3D)

Secondary accessions: Q7Z3K0 Q8WWM8 Q96CC1 Q9UG57

Alternative splicing: 3 isoforms: O15294-1 O15294-2 O15294-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_858058.1 NP_858059.1

ENSEMBL proteins:

ENSP00000362824 ENSP00000362805

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (O-Linked N-Acetylglucosamine Transferase)
	Human Recombinant Proteins from Abnova (OGT)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	9083067
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	TAS	9083067

About this table

Antibodies for OGT:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for OGT
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (O-Linked N-Acetylglucosamine Transferase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (OGT)
	Novus Biologicals Antibody for OGT

Assays for OGT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15294

ProtoNet protein and cluster: O15294

UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294

Similarity: Belongs to the O-GlcNAc transferase family

Similarity: Contains 13 TPR repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OGT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003605

Applied Biosystems Silencer® siRNAs for OGT

Sigma-Aldrich siRNA for OGT

Sigma-Aldrich shRNA for OGT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OGT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_181672
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_181672
untagged cDNA clones in CMV expression vector (see all 3): NM_003605

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_181672

UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294

Function: Addition of nucleotide-activated sugars directly onto the polypeptide through

O-glycosidic linkage with the hydroxyl of serine or threonine

Catalytic activity: UDP-N-acetyl-D-glucosamine + peptide = UDP +

N-acetyl-beta-D-glucosaminyl-peptide

Enzyme Number (IUBMB): EC 2.4.1.-

Genatlas biochemistry entry for OGT:

O-linked N-acetylglucosamine (GlcNAc) transferase,putative part of a glucose-responsive pathway

implicated in the pathogenesis of diabetes mellitus

9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ogt):

behavior/neurological	cellular	growth/size	hematopoietic system	immune system
lethality-postnatal	lethality-prenatal/perinatal	normal	reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12670868
GO:0008375	acetylglucosaminyltransferase activity	TAS	9083068
GO:0016757	transferase activity, transferring glycosyl groups	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294

Pathway: Protein modification; protein glycosylation

Gene Network Central^TM Interacting Genes and Proteins Network for OGT

5/56 Interacting proteins for OGT (O15294^{1, 2} ENSP00000362824³) via UniProtKB, MINT, and/or STRING (see all 56 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK2	P24941¹	EBI-539828, EBI-375096
FIBP	O43427¹	EBI-539828, EBI-724809
HCFC1	P51610¹	EBI-539828, EBI-396176
WDR8	Q9P2S5¹	EBI-539828, EBI-1054904
NFATC1	O95644²	MINT-6167028 MINT-6166975

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006493	protein amino acid O-linked glycosylation	TAS	9083067
GO:0007165	signal transduction	TAS	9083067
GO:0007584	response to nutrient	TAS	9083068

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OGT
6 Novoseek chemical compound relationships for OGT gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
n-acetylglucosamine	84.48	12	12504895 (1), 16382487 (1), 11554736 (1), 14749383 (1) (see all 12)
udp-n-acetylglucosamine	68.35	2	15305040 (1), 12373287 (1)
threonine	52.18	5	16382487 (1), 14749383 (1), 12373287 (1), 18519567 (1) (see all 5)
alloxan	49.34	2	12373287 (1)
tyrosine	16.99	12	18519567 (2), 19238206 (2), 9083067 (1), 15147958 (1)
glucose	14.36	14	18353774 (5), 18174169 (3), 12373287 (1), 18323454 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OGT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003605

Sigma-Aldrich siRNA for OGT

Sigma-Aldrich shRNA for OGT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_181672 NM_181673

REFSEQ mRNAs for OGT gene (2 alternative transcripts):

NM_181672.1 NM_181673.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_181672 NM_181673

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_181672
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_181672
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_003605

Additional cDNA sequence:

AF070560.1 AF147394.1 AF223393.1 AK300267.1 AK313530.1 AL049950.1 AL050366.1 AL833085.2

BC014434.1 BC015144.1 BC038180.1 BX537844.1 U77413.1

24/27 DOTS entries (see all 27 ):

DT.91967229 DT.99931287 DT.100822668 DT.95252610 DT.452005 DT.100822669 DT.101958541 DT.121302034

DT.95252653 DT.95252613 DT.40288601 DT.102833715 DT.102833716 DT.121302019 DT.95252611 DT.95252639

DT.95252651 DT.95363744 DT.100665946 DT.100729590 DT.100748147 DT.121301968 DT.121301976 DT.40288541

24/422 AceView cDNA sequences (see all 422 ):

AI708921 BP360404 AI671772 AI510713 AI886433 BU161128 AA331819 AW591624

CA414573 BE698198 AW873135 AA808426 AI660100 AL050366 AW948847 AA890003

AI589843 CA390300 AW204026 AI332788 CB162206 CN482977 BQ316752 BE350289

highest scoring ESTs for OGT:

AL050366 U77413 AA057494 AA058478 AA187860 AA253130 AA258557 AA258718 AA278681 AA353062

Unigene Cluster for OGT:

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

Hs.405410 [show with all ESTs]

Unigene Representative Sequence: AL050366

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for OGT (see all 13 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^
SP1:									-						-		-								-		-		-		-
SP2:									-		-				-		-								-		-		-		-
SP3:
SP4:																																					-
SP5:									-		-		-		-		-		-		-		-		-		-		-		-		-				-

ExUns:	16	^	17	^	18	^	19	^	20	^	21a	·	21b	·	21c	^	22a	·	22b	^	23	^	24a	·	24b	·	24c	^	25	^	26
SP1:															-				-
SP2:															-				-
SP3:															-				-
SP4:															-				-
SP5:

About this scheme

ECgene alternative splicing isoforms for OGT

2 Ensembl transcripts including schematic representations:

ENST00000373719 ENST00000373701

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OGT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OGT

¹ / ² / ³

13 probe-sets matching OGT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39507_at²^{, 3}	U95-A	1	1.00	1.00	0.82	1.31	AL050366	1.00	1.00	1.00	1
38614_s_at²^{, 3}	U95-A	1	1.00	1.00	0.87	1.15	U77413	1.00	1.00	1.00	1
79064_at²^{, 3}	U95-D	1	0.94	1.00	0.81	0.57	AI684473	0.60	1.00	0.82	1
212307_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF001665	0.80	1.00	0.91	1
209240_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF070560	0.80	1.00	0.91	1
207564_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003605	0.40	1.00	0.76	1
207563_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U77413	1.00	1.00	1.00	1
220594_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_025192	0.20	1.00	0.72	1
212307_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209240_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207564_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207563_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220594_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTTGCAGATA

SOURCE GeneReport for Unigene cluster: Hs.405410
Expression variation in blood from EXPOLDB for OGT
UniProtKB/Swiss-Prot: OGT1_HUMAN, O15294
Tissue specificity: Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart,
brain and placenta. Present in trace amounts in lung and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OGT gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OGT¹	--	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl more	95.25(n) 99.71(a)	480955 XM_853825.1 XP_858918.1
cow (Bos taurus)	OGT¹	--	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl more	94.62(n) 99.78(a)	532053 XM_610562.3 XP_610562.3
rat (Rattus norvegicus)	Ogt¹	--	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl more	92.21(n) 99.42(a)	26295 NM_017107.1 NP_058803.1
mouse (Mus musculus)	Ogt^{1, 5}	X⁵	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl more^{1, 5}	92.45(n)¹ 99.62(a)¹	108155¹ NM_139144.2¹ NP_631883.2¹ AF363030⁵ AF539527⁵ (see all 27)
chicken (Gallus gallus)	OGT¹	--	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl more	83.99(n) 97.58(a)	422203 XM_001232518.1 XP_001232519.1

About this table Species with no ortholog for OGT

ENSEMBL Gene Tree for OGT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OGT gene

TMTC4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/98 NCBI SNPs in OGT are shown (see all 98 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 34)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12008091^1,2	C,F,H	70667991(+)	`AGGCTT/ACAGAT`	2	--	ng5¹		4		EU EA WA	418
	rs34739713^1,2	F	70694160(-)	`GGATGC/TACAGA`	2	V/V	syn¹		1		NA	78
	rs34350994^1,2	F	70693641(-)	`GCAAAT/GGCAGG`	2	A/A	syn¹		1		NA	78
	rs6525488^1,2	A,C,F,H	70692427(+)	`TCTGTA/GGCATT`	2	--	int¹		8		EU EA WA	628
	rs5936630^1,2	A,C,F,H	70671259(+)	`TCTGTA/GCTGGA`	2	--	int¹		4		EU EA WA	418
	rs6525489^1,2	A,C,F,H	70703651(+)	`agtccG/Atgtgg`	2	--	int¹		2		EU WA	240
	rs3736670^1,2	A,C,F,H	70693455(+)	`ACAACG/AGAATA`	2	--	int¹		6		EU EA WA	596
	rs2878161^1,2	A,C,H	70695271(-)	`TTTTAG/AAAAAT`	2	--	int¹		4		EU EA WA	418
	rs11796215^1,2	C,F,H	70678006(+)	`CAATGC/ATTTGT`	2	--	int¹		4		EU EA WA	418
--	rs11094204^1,2	A,C	70680343(+)	`tgtgtA/Gtatat`	2	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for OGT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300255

3 Novoseek disease relationships for OGT gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neurodegenerative diseases	18.03	2	16714295 (1), 12911634 (1)
alzheimers disease	11.50	4	16714295 (1), 12911634 (1)
insulin resistance	11.42	2	18288188 (1), 10753899 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/88 PubMed articles for OGT gene (see all 88 ):

O-linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. (PubMed id 9083068)^{2, 3, 4} Lubas W.A.... Hanover J.A. (1997)
Human O-GlcNAc transferase (OGT): genomic structure, analysis of splice variants, fine mapping in Xq13.1. (PubMed id 11773972)^{1, 3, 4} Nolte D. and Muller U. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. (PubMed id 12670868)^{3, 4} Wysocka J....Herr W. (2003)
UDP-N-acetylglucosaminyl transferase (OGT) in brain tissue: temperature sensitivity and subcellular distribution of cytosolic and nuclear enzyme. (PubMed id 12911634)^{1, 3} Okuyama R. and Marshall S. (2003)
Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity. (PubMed id 12724313)^{1, 3} Iyer S.P. and Hart G.W. (2003)
Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene. (PubMed id 12504895)^{1, 3} Hanover J.A....Love D.C. (2003)
Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase. (PubMed id 12538765)^{1, 3} Love D.C....Kochran J. (2003)
Functional expression of O-linked GlcNAc transferase. Domain structure and substrate specificity. (PubMed id 10753899)^{1, 3} Lubas W.A. and Hanover J.A. (2000)
OGT functions as a catalytic chaperone under heat stress response: a unique defense role of OGT in hyperthermia. (PubMed id 15336570)^{1, 3} Sohn K.C....Do S.I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8473	HGNC: 8127	AceView: OGT	Ensembl:ENSG00000147162	euGenes: HUgn8473
ECgene: OGT	H-InvDB: OGT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_554

Licensable Technologies for OGT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OGT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OGT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OGT		Antibodies for OGT
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OGT		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (OGT)
	Antibodies (OGT)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (O-Linked N-Acetylglucosamine Transferase)
	Antibodies (O-Linked N-Acetylglucosamine Transferase)

Search OriGene for OGT

Search Tocris compounds for OGT

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for OGT

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
OGT Gene at Home site.
Version 2.41.1
server5.xennexinc.com

OGT Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for OGT

Summaries
for OGT

Genomic Location
for OGT

Proteins
for OGT

Protein Domains/
Families
for OGT

Gene Function
for OGT

Pathways & Interactions
for OGT

Drugs & Compounds
for OGT

Transcripts
for OGT

Expression
for OGT

Orthologs
for OGT

Paralogs
for OGT

SNPs/Variants
for OGT

Disorders & Mutations
for OGT

Medical News
for OGT

Publications
for OGT

Search for OGT

Genome Databases showing OGT

Other Databases showing OGT

Specialized Databases showing OGT

Licensable Technologies
for OGT

Services
for OGT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OGT Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor OGT

Summariesfor OGT

Genomic Locationfor OGT

Proteinsfor OGT

Protein Domains/Familiesfor OGT

Gene Functionfor OGT

Pathways & Interactionsfor OGT

Drugs & Compoundsfor OGT

Transcriptsfor OGT

Expression for OGT

Orthologsfor OGT

Paralogsfor OGT

SNPs/Variantsfor OGT

Disorders & Mutationsfor OGT

Medical Newsfor OGT

Publicationsfor OGT

Search for OGT

Genome Databases showing OGT

Other Databases showing OGT

Specialized Databases showing OGT

Licensable Technologiesfor OGT

Servicesfor OGT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OGT

Summaries
for OGT

Genomic Location
for OGT

Proteins
for OGT

Protein Domains/
Families
for OGT

Gene Function
for OGT

Pathways & Interactions
for OGT

Drugs & Compounds
for OGT

Transcripts
for OGT

Expression
for OGT

Orthologs
for OGT

Paralogs
for OGT

SNPs/Variants
for OGT

Disorders & Mutations
for OGT

Medical News
for OGT

Publications
for OGT

Licensable Technologies
for OGT

Services
for OGT