Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OGT Gene

Aliases for OGT Gene

  • O-Linked N-Acetylglucosamine (GlcNAc) Transferase 2 3
  • O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:Polypeptide-N-Acetylglucosaminyl Transferase) 2 3
  • UDP-N-Acetylglucosamine:Polypeptide-N-Acetylglucosaminyl Transferase 2 3
  • O-Linked N-Acetylglucosamine Transferase 110 KDa Subunit 3 4
  • O-GlcNAc Transferase Subunit P110 3 4
  • Uridinediphospho-N-Acetylglucosamine:Polypeptide Beta-N-Acetylglucosaminyl Transferase 3
  • UDP-N-Acetylglucosamine--Peptide N-Acetylglucosaminyltransferase 110 KDa Subunit 3
  • O-GlcNAc Transferase P110 Subunit 3
  • EC 2.4.1.186 63
  • EC 2.4.1.255 4
  • O-GLCNAC 3
  • EC 2.4.1 63
  • HRNT1 3

External Ids for OGT Gene

Previous GeneCards Identifiers for OGT Gene

  • GC0XP066927
  • GC0XP068231
  • GC0XP068986
  • GC0XP069619
  • GC0XP070535
  • GC0XP070669
  • GC0XP070752
  • GC0XP064568

Summaries for OGT Gene

Entrez Gene Summary for OGT Gene

  • This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for OGT Gene

OGT (O-Linked N-Acetylglucosamine (GlcNAc) Transferase) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism and RNA Polymerase I Promoter Opening. GO annotations related to this gene include enzyme activator activity and acetylglucosaminyltransferase activity. An important paralog of this gene is TMTC3.

UniProtKB/Swiss-Prot for OGT Gene

  • Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the Thr-308 phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of Ser-112 of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of Ser-75 of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins ARNTL/BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2 (PubMed:12150998, PubMed:18288188, PubMed:19377461, PubMed:19451179, PubMed:20018868, PubMed:20200153, PubMed:21285374, PubMed:15361863).

  • Isoform 2: the mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line

Gene Wiki entry for OGT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGT Gene

Genomics for OGT Gene

Regulatory Elements for OGT Gene

Transcription factor binding sites by QIAGEN in the OGT gene promoter:

Genomic Location for OGT Gene

Start:
71,533,062 bp from pter
End:
71,575,897 bp from pter
Size:
42,836 bases
Orientation:
Plus strand

Genomic View for OGT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OGT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGT Gene

Proteins for OGT Gene

  • Protein details for OGT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15294-OGT1_HUMAN
    Recommended name:
    UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
    Protein Accession:
    O15294
    Secondary Accessions:
    • Q7Z3K0
    • Q8WWM8
    • Q96CC1
    • Q9UG57

    Protein attributes for OGT Gene

    Size:
    1046 amino acids
    Molecular mass:
    116925 Da
    Quaternary structure:
    • Heterotrimer; consists of one 78 kDa subunit and two 110 kDa subunits dimerized via TPR repeats 6 and 7. Interacts (via TPR repeats 6 and 7) with ATXN10 (By similarity). Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, HCFC1, PPP1CC and ACTB. Component of a THAP1/THAP3-HCFC1-OGT complex. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts directly with HCFC1; the interaction O-glycosylates HCFC1, regulates its proteolytic processing and transcriptional activity and, in turn, stabilizes OGT in the nucleus. Interacts (via TPRs 1-6) with SIN3A; the interaction mediates transcriptional repression in parallel with histone deacetylase. Interacts (via TPR 5-6) with TET1, TET2 and TET3. Interacts with ARNTL/BMAL1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for OGT Gene

    Alternative splice isoforms for OGT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGT Gene

Proteomics data for OGT Gene at MOPED

Post-translational modifications for OGT Gene

  • Phosphorylation on Ser-3 or Ser-4 by GSK3-beta positively regulates its activity.
  • Ubiquitinated, leading to its proteasomal degradation.
  • Ubiquitination at Lys16, Lys83, Lys100, Lys168, Lys337, Lys644, Lys724, Lys742, Lys971, and Lys1010
  • Modification sites at PhosphoSitePlus

Other Protein References for OGT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for OGT Gene

Gene Families for OGT Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for OGT Gene

Graphical View of Domain Structure for InterPro Entry

O15294

UniProtKB/Swiss-Prot:

OGT1_HUMAN :
  • O15294
Domain:
  • The TPR repeat domain is required for substrate binding and oligomerization.
Family:
  • Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
Similarity:
  • Contains 13 TPR repeats.
genes like me logo Genes that share domains with OGT: view

Function for OGT Gene

Molecular function for OGT Gene

GENATLAS Biochemistry: O-linked N-acetylglucosamine (GlcNAc) transferase,putative part of a glucose-responsive pathway implicated in the pathogenesis of diabetes mellitus
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1.8 uM for UDP-N-acetyl-D-glucosamine {ECO:0000269 PubMed:21240259};
UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine
UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine
UniProtKB/Swiss-Prot EnzymeRegulation: Subject to product inhibition by UDP.
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the Thr-308 phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of Ser-112 of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of Ser-75 of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins ARNTL/BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2 (PubMed:12150998, PubMed:18288188, PubMed:19377461, PubMed:19451179, PubMed:20018868, PubMed:20200153, PubMed:21285374, PubMed:15361863).
UniProtKB/Swiss-Prot Function: Isoform 2: the mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line
UniProtKB/Swiss-Prot Induction: Induction of the nucleocytoplasmic OGT (ncOGT) isoform in the liver on glucose deprivation is mediated by the decreased hexosamine biosynthesis pathway (HBP) flux.

Enzyme Numbers (IUBMB) for OGT Gene

Gene Ontology (GO) - Molecular Function for OGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12150998
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 18288188
GO:0008047 enzyme activator activity IDA --
GO:0008375 acetylglucosaminyltransferase activity TAS 9083068
GO:0016262 protein N-acetylglucosaminyltransferase activity IDA --
genes like me logo Genes that share ontologies with OGT: view
genes like me logo Genes that share phenotypes with OGT: view

miRNA for OGT Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for OGT Gene

Localization for OGT Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGT Gene

Isoform 2: Mitochondrion. Membrane. Note=Associates with the mitochondrial inner membrane.
Isoform 3: Cytoplasm. Nucleus. Cell membrane. Note=Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1. After insulin induction, translocated from the nucleus to the cell membrane via phophatidylinisotide binding. Colocalizes with AKT1 at the plasma membrane.
Isoform 4: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OGT Gene COMPARTMENTS Subcellular localization image for OGT gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
plasma membrane 5
cytoskeleton 4
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
GO:0005634 nucleus IDA 21285374
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with OGT: view

Pathways for OGT Gene

genes like me logo Genes that share pathways with OGT: view

Pathways by source for OGT Gene

1 Cell Signaling Technology pathway for OGT Gene
1 KEGG pathway for OGT Gene

UniProtKB/Swiss-Prot O15294-OGT1_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for OGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process IDA 22923583
GO:0006325 chromatin organization TAS --
GO:0006493 protein O-linked glycosylation IMP 23353889
GO:0006915 apoptotic process IDA 20824293
GO:0007165 signal transduction TAS 9083067
genes like me logo Genes that share ontologies with OGT: view

Compounds for OGT Gene

(5) HMDB Compounds for OGT Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Lactosamine
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
13000-25-4
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7

(8) Novoseek inferred chemical compound relationships for OGT Gene

Compound -log(P) Hits PubMed IDs
n-acetylglucosamine 84.4 13
udp-n-acetylglucosamine 66.4 2
threonine 57 6
alloxan 46.8 1
serine 44.7 6
genes like me logo Genes that share compounds with OGT: view

Transcripts for OGT Gene

Unigene Clusters for OGT Gene

O-linked N-acetylglucosamine (GlcNAc) transferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OGT Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3:
SP4: -
SP5: - - - - - - - - - - - - - -
SP6: - - -
SP7:
SP8: - -
SP9: - - - -
SP10: - - - -
SP11: -
SP12:
SP13:

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

Relevant External Links for OGT Gene

GeneLoc Exon Structure for
OGT
ECgene alternative splicing isoforms for
OGT

Expression for OGT Gene

mRNA expression in normal human tissues for OGT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OGT Gene

SOURCE GeneReport for Unigene cluster for OGT Gene Hs.405410

mRNA Expression by UniProt/SwissProt for OGT Gene

O15294-OGT1_HUMAN
Tissue specificity: Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver.
genes like me logo Genes that share expressions with OGT: view

No data available for mRNA differential expression in normal tissues for OGT Gene

Orthologs for OGT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OGT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGT 35
  • 90.98 (n)
  • 88.68 (a)
cow
(Bos Taurus)
Mammalia OGT 35
  • 94.95 (n)
  • 99.81 (a)
OGT 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OGT 35
  • 95.25 (n)
  • 99.71 (a)
OGT 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ogt 35
  • 92.45 (n)
  • 99.62 (a)
Ogt 16
Ogt 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OGT 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 13 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ogt 35
  • 92.25 (n)
  • 99.52 (a)
chicken
(Gallus gallus)
Aves OGT 35
  • 83.99 (n)
  • 97.58 (a)
OGT 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGT 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25936 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ogt 35
  • 80.39 (n)
  • 95.94 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10249 35
zebrafish
(Danio rerio)
Actinopterygii ogt.1 35
  • 78.2 (n)
  • 93.38 (a)
ogt.1 36
  • 92 (a)
OneToMany
ogt.2 36
  • 85 (a)
OneToMany
wufr75f09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006254 35
  • 66.43 (n)
  • 80.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta sxc 35
  • 67.43 (n)
  • 78 (a)
sxc 36
  • 75 (a)
OneToOne
Ogt 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea ogt-1 35
  • 63.54 (n)
  • 68.74 (a)
ogt-1 36
  • 61 (a)
OneToOne
K04G7.3 37
  • 68 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SEC 35
  • 52.33 (n)
  • 46.39 (a)
rice
(Oryza sativa)
Liliopsida Os.45968 35
wheat
(Triticum aestivum)
Liliopsida Ta.28845 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15222 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 76 (a)
OneToOne
Species with no ortholog for OGT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for OGT Gene

ENSEMBL:
Gene Tree for OGT (if available)
TreeFam:
Gene Tree for OGT (if available)

Paralogs for OGT Gene

Paralogs for OGT Gene

genes like me logo Genes that share paralogs with OGT: view

Variants for OGT Gene

Sequence variations from dbSNP and Humsavar for OGT Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs720617 -- 71,541,878(+) TAGTT(C/T)TACAG intron-variant
rs1063695 -- 71,546,162(+) GTATG(A/C)AATAG intron-variant, utr-variant-5-prime
rs2272780 -- 71,537,817(+) CTTGT(C/T)GCCTT intron-variant
rs2878161 -- 71,558,696(-) TTTTA(A/G)AAAAT intron-variant
rs3736670 -- 71,556,880(+) ACAAC(A/G)GAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OGT Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv33082 CNV Loss 17666407
esv2740213 CNV Deletion 23290073

Relevant External Links for OGT Gene

HapMap Linkage Disequilibrium report
OGT
Locus Specific Mutation Databases (LSDB)
OGT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGT Gene

Disorders for OGT Gene

UniProtKB/Swiss-Prot

OGT1_HUMAN
  • Note=Regulation of OGT activity and altered O-GlcNAcylations are implicated in diabetes and Alzheimer disease. O-GlcNAcylation of AKT1 affects insulin signaling and, possibly diabetes. Reduced O-GlcNAcylations and resulting increased phosphorylations of MAPT/TAU are observed in Alzheimer disease (AD) brain cerebrum.

(2) University of Copenhagen DISEASES for OGT Gene

(4) Novoseek inferred disease relationships for OGT Gene

Disease -log(P) Hits PubMed IDs
neurodegenerative diseases 35.1 3
insulin resistance 23.9 2
alzheimers disease 7.67 2
cancer 0 2

Relevant External Links for OGT

Genetic Association Database (GAD)
OGT
Human Genome Epidemiology (HuGE) Navigator
OGT
genes like me logo Genes that share disorders with OGT: view

Publications for OGT Gene

  1. Human O-GlcNAc transferase (OGT): genomic structure, analysis of splice variants, fine mapping in Xq13.1. (PMID: 11773972) Nolte D. … Muller U. (Mamm. Genome 2002) 3 4 23
  2. Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. (PMID: 12150998) Yang X. … Kudlow J.E. (Cell 2002) 3 4 23
  3. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. (PMID: 18288188) Yang X. … Evans R.M. (Nature 2008) 3 4 23
  4. O-linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. (PMID: 9083068) Lubas W.A. … Hanover J.A. (J. Biol. Chem. 1997) 2 3 4
  5. The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias. (PMID: 20200153) Mazars R. … Girard J.P. (J. Biol. Chem. 2010) 3 4 23

Products for OGT Gene

Sources for OGT Gene

Back to Top

Content