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Aliases & Descriptions for OGN
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DKFZp586P2421 2 OG 2 OIF 1 , 2 , 3 , 5 OTTHUMP00000021650 2 OTTHUMP00000021651 2 OTTHUMP00000063691 2 Osteoglycin 3 SLRR3A 1 , 2 , 3 mimecan 1 osteoglycin 2
Descriptions Osteoinductive factor 2 , 3 corneal keratan sulfate proteoglycan 2 mimecan proteoglycan 2 osteoglycin (osteoinductive factor) 1
Search outside databases for aliases for OGN genePrevious GC identifers: GC09M085972 GC09M086874 GC09M088445 GC09M090487 GC09M092225
Summaries for OGN (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for OGN : This gene encodes a protein which induces ectopic bone formation in conjunction with transforminggrowth factor beta. This protein is a small proteoglycan which contains tandem leucine-richrepeats (LRR). Alternatively spliced transcript variants that encode the same protein have beenfound for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: MIME_HUMAN, P20774 Function : Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2
Gene Wiki entry for OGN
Genomic Location for OGN
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the OGN gene Entrez Gene cytogenetic band: 9q22 Ensembl cytogenetic band: 9q22.31 HGNC cytogenetic band: 9q22 OGN Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M094187:
(about GC identifiers )
Start:
94,186,070 bp from pter
End:
94,206,758 bp from pter
Size:
20,689 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000009.10 NT_008470.18 Proteins for OGN
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MIME_HUMAN, P20774 (See
protein sequence )Recommended Name: Mimecan precursor Size : 298 amino acids; 33922 Da
Subcellular location : Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions : Q6FIB0 Q9UF90 Q9UNK5
REFSEQ proteins (3 alternative transcripts):
NP_054776.1 NP_077727.2 NP_148935.1 ENSEMBL proteins: ENSP00000262551 ENSP00000364711 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: OGN 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for OGN: Assays for OGN:
Protein
Domains/ Families for OGN(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P20774 ProtoNet protein and cluster: P20774
2 Blocks protein families : IPB000372 Cysteine-rich flanking region IPB001611 Leucine-rich repeat signature UniProtKB/Swiss-Prot: MIME_HUMAN, P20774 Similarity : Belongs to the small leucine-rich proteoglycan (SLRP) family. Class III subfamilySimilarity : Contains 7 LRR (leucine-rich) repeats
Gene Function for OGN
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_014057 Applied Biosystems Silencer ® siRNAs for OGN Sigma-Aldrich siRNA for OGN Sigma-Aldrich shRNA Panels and shRNA for OGN Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_014057                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_014057                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_014057  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014057 UniProtKB/Swiss-Prot: MIME_HUMAN, P20774 Function : Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ogn) :3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for OGN
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Interacting proteins for OGN (P20774 1 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
About this table
Drugs & Compounds for OGN (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for OGN 2 Novoseek chemical compound relationships for OGN gene
About this table
Transcripts for OGN(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_014057 Sigma-Aldrich siRNA for OGN Sigma-Aldrich shRNA Panels and shRNA for OGN Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_014057 NM_033014
REFSEQ mRNAs for OGN gene (3 alternative transcripts): NM_014057.3 NM_024416.3 NM_033014.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014057 NM_033014
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_014057                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_014057                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_014057  
Additional cDNA sequence: AF086912.1 AF088023.1 AF100758.1 AF173383.1 AF202167.1 AK075521.1 AK129845.1 AK289628.1 AK295433.1 AL110267.1 AL133114.1 BC037273.2 BC095443.1 CR533516.1 CR614070.1 CR626599.1
15 DOTS entries : DT.100826483 DT.97822276 DT.75198622 DT.100678500 DT.95313043 DT.100826474 DT.40132340 DT.95256527 DT.100826472 DT.100826476 DT.121154237 DT.121154326 DT.121154252 DT.121154257 DT.121154292
24/293 AceView cDNA sequences (see all 293
):CB268982 AF086912 BQ183020 AA889218 AI088387 AA708797 CD678059 BM679549 AW475049 BQ773911 BM678441 AW020116 CR626599 CR533516 AA332194 AI700865 N56025 AK129845 AW305161 AA904959 W21015 T97739 D63063 D62922
highest scoring ESTs for OGN :AA295227 AF086912 AF100758 AI934365 AL600087 AL600239 AL602622 AW020116 BQ721136 BX489477
Unigene Cluster for OGN: Osteoglycin Hs.109439 [show with all ESTs ] Unigene Representative Sequence: NM_033014 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for OGN ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 SP1 :     -                     SP2 :     -   -                   SP3 :                        
About this scheme ECgene alternative splicing isoforms for OGN 2 Ensembl transcripts including schematic representations : ENST00000262551
ENST00000375561
Expression for OGN
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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OGN expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for OGN 1 / 2 / 3
7 probe-sets matching OGN gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CCTCATTTCCSOURCE GeneReport for Unigene cluster: Hs.109439 UniProtKB/Swiss-Prot: MIME_HUMAN, P20774 Tissue specificity : Bone
Orthologs for OGN
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for OGN gene from 5/8 species (see all 8
)
About this table Species with no ortholog for OGN ENSEMBL Gene Tree for OGN Paralogs for OGN (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for OGN gene OPTC 2 EPYC 2
SNPs/Variants for OGN (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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Disorders & Mutations for OGN
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 602383
Medical News for OGN (Possibly Related Articles in
Doctor's Guide )
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Publications for OGN (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/48 PubMed articles for OGN gene (see all 48
): Molecular cloning of a novel bone-forming compound: osteoinductive factor. (PubMed id 2372374) 1, 2, 3, 4 Madisen L.... Purchio A.F. (1990) Mutations in KERA, encoding keratocan, cause cornea plana. (PubMed id 10802664) 1, 3, 4 Pellegata N.S....de la Chapelle A. (2000) The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon. (PubMed id 10373482) 1, 3, 4 Tasheva E.S....Conrad G.W. (1999) Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161) 3, 4 Zhang Z. and Henzel W.J. (2004) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 3, 4 Humphray S.J.... Dunham I. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 3, 4 Wiemann S.... Poustka A. (2001) Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946) 3, 4 Hu R.-M.... Chen J.-L. (2000) Osteoinductive factor inhibits formation of human osteoclast-like cells. (PubMed id 2326263) 1, 3 Kukita A....Roodman G.D. (1990) Expression studies of osteoglycin/mimecan (OGN) in the cochlea and auditory phenotype of Ogn-deficient mice. (PubMed id 18243607) 1, 3 Williamson R.E....Tasheva E.S. (2008)
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Genome Databases showing OGN
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing OGN
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Specialized Databases showing OGN (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for OGN (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for OGN:
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