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OGN Gene

protein-coding   GIFtS: 54

GC09M094187
osteoglycin
(Previous name: osteoglycin (osteoinductive factor) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp586P2421 2
OG 2
OIF 1, 2, 3, 5
OTTHUMP00000021650 2
OTTHUMP00000021651 2
OTTHUMP00000063691 2
Osteoglycin 3
SLRR3A 1, 2, 3
mimecan 1
osteoglycin 2
Descriptions
Osteoinductive factor 2, 3
corneal keratan sulfate proteoglycan 2
mimecan proteoglycan 2
osteoglycin (osteoinductive factor) 1
External Ids
HGNC: 81261
Entrez Gene: 49692
UniProtKB: P207743
Ensembl: ENSG000001068097
Search outside databases for aliases for OGN gene

Previous GC identifers: GC09M085972 GC09M086874 GC09M088445 GC09M090487 GC09M092225

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OGN:
This gene encodes a protein which induces ectopic bone formation in conjunction with transforming
growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich
repeats (LRR). Alternatively spliced transcript variants that encode the same protein have been
found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MIME_HUMAN, P20774
Function: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2

Gene Wiki entry for OGN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OGN gene  

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22

OGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M094187:     (about GC identifiers)

Start:
94,186,070 bp from pter
End:
94,206,758 bp from pter
Size:
20,689 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000009.10  NT_008470.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MIME_HUMAN, P20774 (See protein sequence)
Recommended Name: Mimecan precursor  
Size: 298 amino acids; 33922 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q6FIB0 Q9UF90 Q9UNK5

REFSEQ proteins (3 alternative transcripts): 
NP_054776.1  NP_077727.2  NP_148935.1  


ENSEMBL proteins: 
ENSP00000262551 ENSP00000364711 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (OIF)
Human Recombinant Proteins from Abnova (OGN)
              OriGene Purified Recombinant Human Protein: OGN 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005578 proteinaceous extracellular matrix IEA--
GO:0005783 endoplasmic reticulum IDA11256614
About this table

Antibodies for OGN: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of OGN
Sigma-Aldrich Antibodies for OGN
R&D Systems Antibodies for OGN (Mimecan)
Antibodies from Abcam (OIF), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (OGN)
Novus Biologicals Antibodies for OGN

Assays for OGN: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro domains/families:
 IPR000372 Leu-rich_rpt_Cys-rich-reg_N
 IPR001611 Leu-rich_rpt


   GeneDecks  OGN for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P20774

ProtoNet protein and cluster: P20774

2 Blocks protein families:
IPB000372 Cysteine-rich flanking region
IPB001611 Leucine-rich repeat signature


UniProtKB/Swiss-Prot: MIME_HUMAN, P20774
Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. Class III subfamily
Similarity: Contains 7 LRR (leucine-rich) repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OGN)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OGN)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_014057

              Applied Biosystems Silencer® siRNAs for OGN

              Sigma-Aldrich siRNA for OGN  
                     Sigma-Aldrich shRNA Panels and shRNA for OGN  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for OGN
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_014057
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_014057
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_014057 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_014057

UniProtKB/Swiss-Prot: MIME_HUMAN, P20774
Function: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2

2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ogn):

skin/coat/nailsvision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003674 molecular_function ND10373482
GO:0005515 protein binding IPI17474147
GO:0008083 growth factor activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Millipore Pathway for OGN
 Selected targets of p53

   GeneDecks  OGN for the pathways selected above  
About GeneDecksing


3 Interacting proteins for OGN (P207741) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
ABL1P005191EBI-1753690, EBI-375543
CRKP461081EBI-1753690, EBI-886
SRCP129311EBI-1753690, EBI-621482
About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008150 biological_process ND10373482
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OGN
2 Novoseek chemical compound relationships for OGN gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
leucine 31.94 1 12704803 (1)
hydroxyapatite 20.89 2 15714505 (1), 15368260 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OGN)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OGN)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_014057

              Sigma-Aldrich siRNA for OGN  
                     Sigma-Aldrich shRNA Panels and shRNA for OGN  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_014057  NM_033014  

REFSEQ mRNAs for OGN gene (3 alternative transcripts): 

NM_014057.3   NM_024416.3   NM_033014.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_014057  NM_033014  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_014057
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_014057
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_014057 

Additional cDNA sequence: 

AF086912.1 AF088023.1 AF100758.1 AF173383.1 AF202167.1 AK075521.1 AK129845.1 AK289628.1 
AK295433.1 AL110267.1 AL133114.1 BC037273.2 BC095443.1 CR533516.1 CR614070.1 CR626599.1 

15 DOTS entries:

DT.100826483  DT.97822276  DT.75198622  DT.100678500  DT.95313043  DT.100826474  DT.40132340  DT.95256527 
DT.100826472  DT.100826476  DT.121154237  DT.121154326  DT.121154252  DT.121154257  DT.121154292 

24/293 AceView cDNA sequences (see all 293 ):

CB268982 AF086912 BQ183020 AA889218 AI088387 AA708797 CD678059 BM679549 
AW475049 BQ773911 BM678441 AW020116 CR626599 CR533516 AA332194 AI700865 
N56025 AK129845 AW305161 AA904959 W21015 T97739 D63063 D62922 

highest scoring ESTs for OGN:

AA295227 AF086912 AF100758 AI934365 AL600087 AL600239 AL602622 AW020116 BQ721136 BX489477 

Unigene Cluster for OGN:

Osteoglycin
Hs.109439  [show with all ESTs]
Unigene Representative Sequence: NM_033014


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for OGN

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1:              -                                                         
SP2:              -     -                                                   
SP3:                                                                        

About this scheme

ECgene alternative splicing isoforms for OGN

2 Ensembl transcripts including schematic representations:
ENST00000262551  ENST00000375561  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OGN expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OGN

1 / 2 / 3

7 probe-sets matching OGN gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
43507_g_at2, 3 U95-B 1 1.00 1.00 0.97 1.10 AW020116 0.80 1.00 0.91 1
65604_at2, 3 U95-C 1 1.00 1.00 0.86 0.90 W06903 0.80 1.00 0.91 1
43506_at2, 3 U95-B 1 1.00 1.00 0.94 1.02 AW020116 0.80 1.00 0.91 1

218730_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014057 0.60 1.00 0.82 1

222722_at2, 3 U133-B 1 1.00 1.00 -- -- AV700059 0.40 1.00 0.76 1

218730_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

222722_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  OGN for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CCTCATTTCC

SOURCE GeneReport for Unigene cluster: Hs.109439

UniProtKB/Swiss-Prot: MIME_HUMAN, P20774
Tissue specificity: Bone

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for OGN gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
OGN1   -- osteoglycin 90.51(n)
90.85(a)
610704  XM_848247.1  XP_853340.1 
chimpanzee
(Pan troglodytes)
OGN1   -- osteoglycin 99.89(n)
99.68(a)
739901  XM_001145343.1  XP_001145343.1 
cow
(Bos taurus)
OGN1   -- osteoglycin 92.32(n)
92.88(a)
280884  NM_173946.1  NP_776371.1 
rat
(Rattus norvegicus)
Ogn1   -- osteoglycin 88.63(n)
85.47(a)
291015  XM_214441.3  XP_214441.1 
mouse
(Mus musculus)
Ogn1, 5 135
osteoglycin1, 5 88.74(n)1
85.47(a)1
182951  NM_008760.31  NP_032786.11 
 AA6477995  AK0142595  (see all 13)
About this table        Species with no ortholog for OGN

ENSEMBL Gene Tree for OGN
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for OGN gene
OPTC2  EPYC2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --
(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602383

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/48 PubMed articles for OGN gene (see all 48 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4969 HGNC: 8126 AceView: OGN Ensembl:ENSG00000106809 euGenes: HUgn4969
ECgene: OGN H-InvDB: OGN
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for OGN Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OGN:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for OGN-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for OGN Antibodies for OGN
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OGN Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (OGN)
 Antibodies (OGN)
 Chimera RNAi (OGN)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(OIF)
 Antibodies (OIF)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for OGN




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for OGN

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