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OGN Gene

protein-coding   GIFtS: 60
GCID: GC09M095146

Osteoglycin

(Previous name: osteoglycin (osteoinductive factor))
  See OGN-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
osteoglycin1 2     SLRR3A2 3
Osteoglycin3     Osteoglycin (Osteoinductive Factor)1
OIF2 3 5     OG2
Mimecan Proteoglycan1 2     Corneal Keratan Sulfate Proteoglycan2
Osteoinductive Factor2 3     mimecan2

External Ids:    HGNC: 81261   Entrez Gene: 49692   Ensembl: ENSG000001068097   OMIM: 6023835   UniProtKB: P207743   

Export aliases for OGN gene to outside databases

Previous GC identifers: GC09M085972 GC09M086874 GC09M088445 GC09M090487 GC09M092225 GC09M094187 GC09M064823


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OGN Gene:
This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor
beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). Alternatively
spliced transcript variants that encode the same protein have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for OGN Gene:
OGN (osteoglycin) is a protein-coding gene. Diseases associated with OGN include vaginal cancer. GO annotations related to this gene include growth factor activity. An important paralog of this gene is OPTC.

UniProtKB/Swiss-Prot: MIME_HUMAN, P20774
Function: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2

Gene Wiki entry for OGN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the OGN gene promoter:
         AML1a   AP-1   FOXO3   FOXO3b   SRY   POU2F1   POU2F1a   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OGN promoter sequence
   Search Chromatin IP Primers for OGN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22

OGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OGN gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M095146:  view genomic region     (about GC identifiers)

Start:
95,146,249 bp from pter      End:
95,166,978 bp from pter
Size:
20,730 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MIME_HUMAN, P20774 (See protein sequence)
Recommended Name: Mimecan precursor  
Size: 298 amino acids; 33922 Da
Secondary accessions: Q6FIB0 Q9UF90 Q9UNK5

Explore the universe of human proteins at neXtProt for OGN: NX_P20774

Explore proteomics data for OGN at MOPED

Post-translational modifications: 

  • N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan1
  • Glycosylation2 at Thr80, Asn214, Asn258

  • See OGN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_054776.1  NP_148935.1  

    ENSEMBL proteins: 
     ENSP00000262551   ENSP00000364711   ENSP00000396709  
    Reactome Protein details: P20774

    OGN Human Recombinant Protein Products:

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    Novus Biologicals OGN Protein
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    Cloud-Clone Corp. Proteins for OGN

     
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    antibodies-online proteins for OGN (16 products) 

     
    antibodies-online peptides for OGN

    OGN Antibody Products:

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    LSBio Antibodies in human, mouse, rat for OGN
    antibodies-online antibodies for OGN (55 products) 

    OGN Assay Products:

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    Cloud-Clone Corp. ELISAs for OGN
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    antibodies-online kits for OGN (15 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLRR: Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR027211 Mimecan
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry P20774

    ProtoNet protein and cluster: P20774

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: MIME_HUMAN, P20774
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily
    Similarity: Contains 7 LRR (leucine-rich) repeats


    Find genes that share domains with OGN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIME_HUMAN, P20774
    Function: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17474147
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with OGN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OGN:
     Decreased viability of wild-ty 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ogn):
     homeostasis/metabolism  integument  vision/eye 

    Find genes that share phenotypes with OGN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for OGN: Ogntm1Hds Ogntm1Eta

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OGN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OGN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OGN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OGN

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate OGN:
    hsa-miR-374a* hsa-miR-577 hsa-miR-22 hsa-miR-361-5p hsa-miR-561 hsa-miR-155 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidOGN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OGN

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): OGN (NM_033014)
    Sino Biological Human cDNA Clone for OGN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGN

    Cell Line
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    PureStem SM30, NCr-fac & Meso-latp Progenitor
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MIME_HUMAN, P20774: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    golgi apparatus4
    lysosome4
    vacuole4
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA--
    GO:0005796Golgi lumen TAS--
    GO:0031012colocalizes with extracellular matrix IDA--

    Find genes that share ontologies with OGN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OGN About   (see all 17)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48


    Find genes that share SuperPaths with OGN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for OGN (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    2 Reactome Pathways for OGN
        Keratan sulfate biosynthesis
    Keratan sulfate degradation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OGN
    Interactions:

        Search GeneGlobe Interaction Network for OGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OGN (P207741, 3 ENSP000002625514) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461081, 3, ENSP000003005744EBI-1753690,EBI-886 I2D: score=1 STRING: ENSP00000300574
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    CHST1ENSP000003092704STRING: ENSP00000309270
    CHST5ENSP000003387834STRING: ENSP00000338783
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0042339keratan sulfate metabolic process TAS--
    GO:0042340keratan sulfate catabolic process TAS--

    Find genes that share ontologies with OGN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OGN (MIME)

    2 Novoseek inferred chemical compound relationships for OGN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 29.4 1 12704803 (1)
    hydroxyapatite 17.7 2 15714505 (1), 15368260 (1)



    Find genes that share compounds with OGN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OGN gene (3 alternative transcripts): 
    NM_014057.3  NM_033014.2  NM_024416.3  

    Unigene Cluster for OGN:

    Osteoglycin
    Hs.109439  [show with all ESTs]
    Unigene Representative Sequence: NM_033014
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262551(uc004asb.3) ENST00000375561(uc004asa.3 uc011ltx.2)
    ENST00000468743 ENST00000447356
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate OGN:
    hsa-miR-374a* hsa-miR-577 hsa-miR-22 hsa-miR-361-5p hsa-miR-561 hsa-miR-155 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidOGN 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat OGN

    Additional mRNA sequence: 

    AF086912.1 AF088023.1 AF100758.1 AF173383.1 AF202167.1 AK075521.1 AK129845.1 AK289628.1 
    AK295433.1 AL110267.1 AL133114.1 BC037273.2 BC095443.1 CR533516.1 

    16 DOTS entries:

    DT.100826483  DT.75198622  DT.97822276  DT.100678500  DT.95313043  DT.100826474  DT.40132340  DT.121154292 
    DT.95256527  DT.121154252  DT.121154257  DT.100826472  DT.100826476  DT.121154237  DT.121154326  DT.95313042 

    Selected AceView cDNA sequences (see all 293):

    AW104259 BI494108 AW020116 AF086912 BM678441 AI127717 AA332194 AA295227 
    D79802 AW305161 AI287305 AI537351 BM666273 AI424992 BQ575863 AF202167 
    AW023728 N56025 AI813984 AW244004 AA327731 AL110267 W21015 D62456 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for OGN    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:              -                                                         
    SP2:              -     -                                                   
    SP3:                                                                        


    ECgene alternative splicing isoforms for OGN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OGN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCATTTCC
    OGN Expression
    About this image


    OGN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 22 entries
             Osteochondro Mesenchymal Cells Vertebrae
             Rib
             Micromass-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 22 entries
             Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
             Intervertebral Disc
             Micromass-induced chondrocytes
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod
    OGN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OGN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.109439

    UniProtKB/Swiss-Prot: MIME_HUMAN, P20774
    Tissue specificity: Bone

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OGN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ogn1 , 5 osteoglycin1, 5 88.7(n)1
    85.23(a)1
      13 (25.34 cM)5
    182951  NM_008760.41  NP_032786.11 
     496080715 
    chicken
    (Gallus gallus)
    Aves OGN1 osteoglycin 70.47(n)
    66.78(a)
      374039  NM_204209.1  NP_989540.1 
    lizard
    (Anolis carolinensis)
    Reptilia OGN6
    osteoglycin
    59(a)
    1 ↔ 1
    2(156236502-156257262)
    African clawed frog
    (Xenopus laevis)
    Amphibia ogn-prov2 osteoglycin 74.72(n)    BC043788.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ogn1 osteoglycin 64.97(n)
    68.06(a)
      541445  NM_001013570.2  NP_001013588.1 


    ENSEMBL Gene Tree for OGN (if available)
    TreeFam Gene Tree for OGN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OGN gene
    OPTC2  EPYC2  
    2 SIMAP similar genes for OGN using alignment to 3 protein entries:     MIME_HUMAN (see all proteins):
    OPTC    EPYC

    Find genes that share paralogs with OGN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OGN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893573CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OGN
    DNA2.0 Custom Variant and Variant Library Synthesis for OGN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602383    OMIM disorders: --

    1 disease for OGN:    
    About MalaCards
    vaginal cancer

    1 disease from the University of Copenhagen DISEASES database for OGN:
    Vaginal cancer

    Find genes that share disorders with OGN           About GenesLikeMe

    Genetic Association Database (GAD): OGN
    Human Genome Epidemiology (HuGE) Navigator: OGN (7 documents)

    Export disorders for OGN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OGN gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with OGN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel bone-forming compound: osteoinductive factor. (PubMed id 2372374)1, 2, 3, 9 Madisen L.... Purchio A.F. (DNA Cell Biol. 1990)
    2. Mutations in KERA, encoding keratocan, cause cornea plana. (PubMed id 10802664)1, 2, 9 Pellegata N.S....de la Chapelle A. (Nat. Genet. 2000)
    3. The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon. (PubMed id 10373482)1, 2, 9 Tasheva E.S....Conrad G.W. (J. Biol. Chem. 1999)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4969 HGNC: 8126 AceView: OGN Ensembl:ENSG00000106809 euGenes: HUgn4969
    ECgene: OGN H-InvDB: OGN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OGN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OGN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OGN gene:
    Search GeneIP for patents involving OGN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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