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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OGN Gene

protein-coding   GIFtS: 61
GCID: GC09M095146

Osteoglycin

(Previous name: osteoglycin (osteoinductive factor))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
osteoglycin1 2     SLRR3A2 3
Osteoglycin3     Osteoglycin (Osteoinductive Factor)1
OIF2 3 5     OG2
Mimecan Proteoglycan1 2     Corneal Keratan Sulfate Proteoglycan2
Osteoinductive Factor2 3     mimecan2

External Ids:    HGNC: 81261   Entrez Gene: 49692   Ensembl: ENSG000001068097   OMIM: 6023835   UniProtKB: P207743   

Export aliases for OGN gene to outside databases

Previous GC identifers: GC09M085972 GC09M086874 GC09M088445 GC09M090487 GC09M092225 GC09M094187 GC09M064823


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OGN Gene:
This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor
beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). Alternatively
spliced transcript variants that encode the same protein have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for OGN Gene: 
OGN (osteoglycin) is a protein-coding gene. Diseases associated with OGN include vaginal cancer, and conjunctivitis, and among its related super-pathways are Rac1 Pathway and Metabolism of carbohydrates. GO annotations related to this gene include protein binding and growth factor activity. An important paralog of this gene is OPTC.

UniProtKB/Swiss-Prot: MIME_HUMAN, P20774
Function: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2

Gene Wiki entry for OGN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OGN gene promoter:
         AML1a   AP-1   FOXO3   FOXO3b   SRY   POU2F1   POU2F1a   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OGN promoter sequence
   Search SABiosciences Chromatin IP Primers for OGN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22

OGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OGN gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M095146:  view genomic region     (about GC identifiers)

Start:
95,146,249 bp from pter      End:
95,166,978 bp from pter
Size:
20,730 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MIME_HUMAN, P20774 (See protein sequence)
Recommended Name: Mimecan precursor  
Size: 298 amino acids; 33922 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q6FIB0 Q9UF90 Q9UNK5

Explore the universe of human proteins at neXtProt for OGN: NX_P20774

Explore proteomics data for OGN at MOPED 

Post-translational modifications:

  • UniProtKB: N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20774

  • OGN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OGN Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_054776.1  NP_148935.1  

    ENSEMBL proteins: 
     ENSP00000262551   ENSP00000364711   ENSP00000396709  
    Reactome Protein details: P20774
    Human Recombinant Protein Products for OGN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
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    OriGene Protein Over-expression Lysate for OGN
    OriGene MassSpec for OGN 
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    GenScript Custom Purified and Recombinant Proteins Services for OGN
    Novus Biologicals OGN Protein
    Novus Biologicals OGN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OGN 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA--
    GO:0005796Golgi lumen TAS--
    GO:0031012colocalizes with extracellular matrix IDA--

    OGN for ontologies           About GeneDecksing



    OGN Antibody Products: 
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    Cloud-Clone Corp. Antibodies for OGN 
    ThermoFisher Antibodies for OGN
    LSBio Antibodies in human, mouse, rat for OGN 

    Assay Products for OGN: 
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    GenScript Custom Assay Services for OGN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OGN 
    Cloud-Clone Corp. CLIAs for OGN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLRR: Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR027211 Mimecan
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry P20774

    ProtoNet protein and cluster: P20774

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: MIME_HUMAN, P20774
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily
    Similarity: Contains 7 LRR (leucine-rich) repeats


    OGN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIME_HUMAN, P20774
    Function: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17474147
    GO:0008083growth factor activity IEA--
         
    OGN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OGN:
     Decreased viability of wild-ty 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ogn):
     homeostasis/metabolism  integument  vision/eye 

    OGN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for OGN: Ogntm1Hds Ogntm1Eta

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OGN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OGN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OGN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OGN 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OGN
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate OGN:
    hsa-miR-374a* hsa-miR-577 hsa-miR-22 hsa-miR-361-5p hsa-miR-561 hsa-miR-155 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidOGN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of OGN

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): OGN (NM_033014)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGN
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                         Customized lentivirus expression plasmids for stable overexpression of OGN 

    Cell Line
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    LifeMap BioReagents: cell lines associated with OGN: Chondrogenic Package 4D20.8,
    Chondrogenic Package 7PEND24, Chondrogenic Package 7SMOO32,
    Chondrogenic Package E15, Chondrogenic Package MEL2,
    Chondrogenic Package SK11, Chondrogenic Package SM30,
    PureStem 7PEND24, NCr-fac & Meso-prx Progenitor, PureStem ES-210, Ecto-ntu Progenitor,
    PureStem SM30, NCr-fac & Meso-latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OGN About   (see all 17)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIIB - Sanfilippo syndrome B0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for OGN
        Selected targets of p53

    5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for OGN (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    5/19        Reactome Pathways for OGN (see all 19)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    MPS II - Hunter syndrome



    OGN for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/22 Interacting proteins for OGN (P207741, 3 ENSP000002625514) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461081, 3, ENSP000003005744EBI-1753690,EBI-886 I2D: score=1 STRING: ENSP00000300574
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    CHST1ENSP000003092704STRING: ENSP00000309270
    CHST6ENSP000003289834STRING: ENSP00000328983
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0042339keratan sulfate metabolic process TAS--
    GO:0042340keratan sulfate catabolic process TAS--

    OGN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OGN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OGN (MIME)

    2 Novoseek inferred chemical compound relationships for OGN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 29.4 1 12704803 (1)
    hydroxyapatite 17.7 2 15714505 (1), 15368260 (1)

    Search CenterWatch for drugs/clinical trials and news about OGN / MIME

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OGN gene (3 alternative transcripts): 
    NM_014057.3  NM_033014.2  NM_024416.3  

    Unigene Cluster for OGN:

    Osteoglycin
    Hs.109439  [show with all ESTs]
    Unigene Representative Sequence: NM_033014
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262551(uc004asb.3) ENST00000375561(uc004asa.3 uc011ltx.2)
    ENST00000468743 ENST00000447356
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OGN
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate OGN:
    hsa-miR-374a* hsa-miR-577 hsa-miR-22 hsa-miR-361-5p hsa-miR-561 hsa-miR-155 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidOGN 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGN
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    Additional mRNA sequence: 

    AF086912.1 AF088023.1 AF100758.1 AF173383.1 AF202167.1 AK075521.1 AK129845.1 AK289628.1 
    AK295433.1 AL110267.1 AL133114.1 BC037273.2 BC095443.1 CR533516.1 

    16 DOTS entries:

    DT.100826483  DT.75198622  DT.97822276  DT.100678500  DT.95313043  DT.100826474  DT.40132340  DT.121154292 
    DT.95256527  DT.121154252  DT.121154257  DT.100826472  DT.100826476  DT.121154237  DT.121154326  DT.95313042 

    24/293 AceView cDNA sequences (see all 293):

    W15431 AW475049 D79830 W21015 AI424992 BM666273 D61808 AW020116 
    BI491148 AA327731 CR614070 BI494108 CR533516 BQ183020 D63133 BM724629 
    AI342123 AI093708 CD678059 AI342112 AI813984 AF086912 AA332194 AW302407 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for OGN    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:              -                                                         
    SP2:              -     -                                                   
    SP3:                                                                        


    ECgene alternative splicing isoforms for OGN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OGN expression in normal human tissues (normalized intensities)      OGN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCATTTCC
    OGN Expression
    About this image


    OGN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 29 entries
             Intervertebral Disc Annulus Fibrosus Cells Thoracic Intervertebral Disc
             Thoracic Intervertebral Disc
             HyStem+TGFbeta3+GDF5-induced SK11 cells
             Normal Human Articular chondrocytes (NHAC)   
             sensory organ/ear/inner ear   
     
     Bone (Muscoskeletal System)    fully expand to see all 23 entries
             Osteochondro Mesenchymal Cells Sacral Vertebrae
             Thoracic Rib
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
             Human Calvarial Osteoblasts (HCO)   
             sensory organ/ear/inner ear   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 5 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Choroid Plexus
             Ciliary Ganglion   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut

    See OGN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OGN

    SOURCE GeneReport for Unigene cluster: Hs.109439

    UniProtKB/Swiss-Prot: MIME_HUMAN, P20774
    Tissue specificity: Bone

        SABiosciences Custom PCR Arrays for OGN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OGN gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ogn1 , 5 osteoglycin1, 5 88.7(n)1
    85.23(a)1
      13 (25.34 cM)5
    182951  NM_008760.41  NP_032786.11 
     496080715 
    chicken
    (Gallus gallus)
    Aves OGN1 osteoglycin 70.47(n)
    66.78(a)
      374039  NM_204209.1  NP_989540.1 
    lizard
    (Anolis carolinensis)
    Reptilia OGN6
    osteoglycin
    61(a)
    1 ↔ 1
    2(156236502-156257262)
    African clawed frog
    (Xenopus laevis)
    Amphibia ogn-prov2 osteoglycin 74.72(n)    BC043788.1 
    zebrafish
    (Danio rerio)
    Actinopterygii OGN (2 of 2)6
    ogn6
    osteoglycin
    56(a)
    52(a)
    1 ↔ many
    1 ↔ many
    23(19968107-19975213)
    22(10564753-10570030)


    ENSEMBL Gene Tree for OGN (if available)
    TreeFam Gene Tree for OGN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OGN gene
    OPTC2  EPYC2  
    2 SIMAP similar genes for OGN using alignment to 3 protein entries:     MIME_HUMAN (see all proteins):
    OPTC    EPYC

    OGN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OGN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893573CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OGN
    DNA2.0 Custom Variant and Variant Library Synthesis for OGN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602383    OMIM disorders: --

    13 diseases for OGN:    About MalaCards
    vaginal cancer    conjunctivitis    vaginitis    paratyphoid fever
    morquio syndrome b    skeletal dysplasias    oligodendroglioma    pituitary tumors
    cholera    adenoma    adenocarcinoma    pancreatitis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for OGN:
    Vaginal cancer

    OGN for disorders           About GeneDecksing

    Genetic Association Database (GAD): OGN
    Human Genome Epidemiology (HuGE) Navigator: OGN (7 documents)

    Export disorders for OGN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OGN gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with OGN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel bone-forming compound: osteoinductive factor. (PubMed id 2372374)1, 2, 3, 9 Madisen L.... Purchio A.F. (1990)
    2. Mutations in KERA, encoding keratocan, cause cornea plana. (PubMed id 10802664)1, 2, 9 Pellegata N.S....de la Chapelle A. (2000)
    3. The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon. (PubMed id 10373482)1, 2, 9 Tasheva E.S....Conrad G.W. (1999)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4969 HGNC: 8126 AceView: OGN Ensembl:ENSG00000106809 euGenes: HUgn4969
    ECgene: OGN H-InvDB: OGN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OGN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OGN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OGN gene:
    Search GeneIP for patents involving OGN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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     Proteins for OGN
     Antibodies for OGN
     ELISAs for OGN
     CLIAs for OGN
     Cell Lines associated with OGN: Chondrogenic Package 4D20.8,
    Chondrogenic Package 7PEND24, Chondrogenic Package 7SMOO32,
    Chondrogenic Package E15, Chondrogenic Package MEL2,
    Chondrogenic Package SK11, Chondrogenic Package SM30,
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGN
     inGenious Targeting Laboratory - Custom generated mouse model solutions for OGN
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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