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Aliases for OGN Gene

Aliases for OGN Gene

  • Osteoglycin 2 3 4 5
  • Osteoinductive Factor 3 4
  • Mimecan Proteoglycan 2 3
  • SLRR3A 3 4
  • OIF 3 4
  • Corneal Keratan Sulfate Proteoglycan 3
  • Osteoglycin (Osteoinductive Factor) 2
  • Mimecan 3
  • OG 3

External Ids for OGN Gene

Previous GeneCards Identifiers for OGN Gene

  • GC09M085972
  • GC09M086874
  • GC09M088445
  • GC09M090487
  • GC09M092225
  • GC09M094187
  • GC09M095146
  • GC09M064823

Summaries for OGN Gene

Entrez Gene Summary for OGN Gene

  • This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for OGN Gene

OGN (Osteoglycin) is a Protein Coding gene. Diseases associated with OGN include Photokeratitis and Disease Of Mental Health. Among its related pathways are Activation of cAMP-Dependent PKA and Metabolism. GO annotations related to this gene include growth factor activity. An important paralog of this gene is EPYC.

UniProtKB/Swiss-Prot for OGN Gene

  • Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

Gene Wiki entry for OGN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGN Gene

Genomics for OGN Gene

Regulatory Elements for OGN Gene

Enhancers for OGN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F092377 0.8 Ensembl ENCODE 16.7 +26.2 26168 2.5 FOXP2 CENPP OGN OMD NOL8 LINC00475 LOC100420779
GH09F092384 0.7 ENCODE 15.8 +19.0 19049 2.0 PKNOX1 HLF CEBPB EP300 NR2F2 YY1 ZNF316 JUND MAFF CEBPA OGN NOL8 CENPP ASPN ECM2 LOC100420779
GH09F092291 0.6 FANTOM5 ENCODE 15.6 +110.7 110680 5.1 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 NOL8 CENPP OGN SPTLC1 IPPK IARS
GH09F092408 1 Ensembl ENCODE 15.4 -5.4 -5407 3.0 HDAC1 PKNOX1 FEZF1 ZEB1 ZNF366 ETV6 CREM ZNF263 ZNF280D CEBPB CENPP OGN NOL8 ECM2 OMD
GH09F092478 1 Ensembl ENCODE 15 -77.2 -77246 5.9 PKNOX1 MXI1 JUN MAX FEZF1 CEBPG BCL11B RAD21 ZBTB40 CTBP1 CENPP NOL8 MTND4P15 OGN MTCO3P29 SPTLC1 ASPN OMD
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OGN on UCSC Golden Path with GeneCards custom track

Promoters for OGN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001910980 1595 3000 ZNF316 RFX1 ZNF366 ZNF24 KLF8 EMSY MAFK

Genomic Location for OGN Gene

Chromosome:
9
Start:
92,383,967 bp from pter
End:
92,404,696 bp from pter
Size:
20,730 bases
Orientation:
Minus strand

Genomic View for OGN Gene

Genes around OGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGN Gene

Proteins for OGN Gene

  • Protein details for OGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20774-MIME_HUMAN
    Recommended name:
    Mimecan
    Protein Accession:
    P20774
    Secondary Accessions:
    • Q6FIB0
    • Q9UF90
    • Q9UNK5

    Protein attributes for OGN Gene

    Size:
    298 amino acids
    Molecular mass:
    33922 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OGN Gene

Post-translational modifications for OGN Gene

  • N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at Thr 80, Asn 214, and Asn 258
  • Modification sites at PhosphoSitePlus

Other Protein References for OGN Gene

Antibody Products

No data available for DME Specific Peptides for OGN Gene

Domains & Families for OGN Gene

Gene Families for OGN Gene

Suggested Antigen Peptide Sequences for OGN Gene

Graphical View of Domain Structure for InterPro Entry

P20774

UniProtKB/Swiss-Prot:

MIME_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
  • Contains 7 LRR (leucine-rich) repeats.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with OGN: view

Function for OGN Gene

Molecular function for OGN Gene

UniProtKB/Swiss-Prot Function:
Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

Gene Ontology (GO) - Molecular Function for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IBA --
GO:0048495 NOT Roundabout binding IBA --
genes like me logo Genes that share ontologies with OGN: view
genes like me logo Genes that share phenotypes with OGN: view

Animal Models for OGN Gene

MGI Knock Outs for OGN:

Animal Model Products

miRNA for OGN Gene

miRTarBase miRNAs that target OGN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OGN Gene

Localization for OGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OGN Gene COMPARTMENTS Subcellular localization image for OGN gene
Compartment Confidence
extracellular 5
golgi apparatus 4
lysosome 4
vacuole 4
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space IDA 20551380
GO:0005796 Golgi lumen TAS --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with OGN: view

Pathways & Interactions for OGN Gene

genes like me logo Genes that share pathways with OGN: view

Gene Ontology (GO) - Biological Process for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis IBA --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0035385 NOT Roundabout signaling pathway IBA --
GO:0042340 keratan sulfate catabolic process TAS --
GO:0048662 negative regulation of smooth muscle cell proliferation ISS --
genes like me logo Genes that share ontologies with OGN: view

No data available for SIGNOR curated interactions for OGN Gene

Drugs & Compounds for OGN Gene

(1) Drugs for OGN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for OGN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OGN: view

Transcripts for OGN Gene

Unigene Clusters for OGN Gene

Osteoglycin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGN Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: - -
SP3:

Relevant External Links for OGN Gene

GeneLoc Exon Structure for
OGN
ECgene alternative splicing isoforms for
OGN

Expression for OGN Gene

mRNA expression in normal human tissues for OGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OGN Gene

This gene is overexpressed in Artery - Aorta (x12.5) and Artery - Coronary (x11.7).

Protein differential expression in normal tissues from HIPED for OGN Gene

This gene is overexpressed in Adipocyte (10.2) and Gallbladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OGN Gene



Protein tissue co-expression partners for OGN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OGN Gene:

OGN

SOURCE GeneReport for Unigene cluster for OGN Gene:

Hs.109439

mRNA Expression by UniProt/SwissProt for OGN Gene:

P20774-MIME_HUMAN
Tissue specificity: Bone.
genes like me logo Genes that share expression patterns with OGN: view

Primer Products

Orthologs for OGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGN 34 35
  • 99.89 (n)
cow
(Bos Taurus)
Mammalia OGN 34 35
  • 92.37 (n)
dog
(Canis familiaris)
Mammalia OGN 34 35
  • 90.57 (n)
mouse
(Mus musculus)
Mammalia Ogn 34 16 35
  • 88.7 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910855 34
  • 88.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OGN 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OGN 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves OGN 34 35
  • 70.47 (n)
lizard
(Anolis carolinensis)
Reptilia OGN 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ogn 34
  • 69.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia ogn-prov 34
zebrafish
(Danio rerio)
Actinopterygii ogn 34 35
  • 64.97 (n)
OGN (1 of 2) 35
  • 56 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7827 34
Species where no ortholog for OGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGN Gene

ENSEMBL:
Gene Tree for OGN (if available)
TreeFam:
Gene Tree for OGN (if available)

Paralogs for OGN Gene

Paralogs for OGN Gene

(2) SIMAP similar genes for OGN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OGN: view

Variants for OGN Gene

Sequence variations from dbSNP and Humsavar for OGN Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1053441 -- 92,385,558(-) CAATG(A/T)GTAAA intron-variant, utr-variant-3-prime
rs1053446 -- 92,384,479(-) ATTAG(A/T)CTACA intron-variant, utr-variant-3-prime
rs10761155 -- 92,391,447(+) TAAAA(C/G)AAGTA intron-variant
rs10820971 -- 92,399,458(+) TCTGT(C/G)AGCTC intron-variant
rs10992321 -- 92,394,193(+) TATTT(G/T)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OGN Gene

Variant ID Type Subtype PubMed ID
esv3891693 CNV gain 25118596
nsv1047337 CNV loss 25217958
nsv1053205 CNV loss 25217958
nsv1128504 CNV deletion 24896259

Variation tolerance for OGN Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGN Gene

Disorders for OGN Gene

MalaCards: The human disease database

(2) MalaCards diseases for OGN Gene - From: DISEASES

Disorder Aliases PubMed IDs
photokeratitis
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards
Search OGN in MalaCards View complete list of genes associated with diseases

Relevant External Links for OGN

Genetic Association Database (GAD)
OGN
Human Genome Epidemiology (HuGE) Navigator
OGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OGN
genes like me logo Genes that share disorders with OGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OGN Gene

Publications for OGN Gene

  1. Molecular cloning of a novel bone-forming compound: osteoinductive factor. (PMID: 2372374) Madisen L. … Purchio A.F. (DNA Cell Biol. 1990) 2 3 4 22 64
  2. Mutations in KERA, encoding keratocan, cause cornea plana. (PMID: 10802664) Pellegata N.S. … de la Chapelle A. (Nat. Genet. 2000) 3 4 22 64
  3. The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon. (PMID: 10373482) Tasheva E.S. … Conrad G.W. (J. Biol. Chem. 1999) 3 4 22 64
  4. Candidate gene study to investigate the genetic determinants of normal variation in central corneal thickness. (PMID: 20360993) Dimasi D.P. … Craig J.E. (Mol. Vis. 2010) 3 22 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for OGN Gene

Sources for OGN Gene

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