Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



OGG1 Gene

protein-coding   GIFtS: 69
GCID: GC03P009791

8-Oxoguanine DNA Glycosylase

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
8-Oxoguanine DNA Glycosylase1 2     HMMH2
8-Hydroxyguanine DNA Glycosylase1 2     HOGG12
MUTM2 3     AP Lyase2
OGH12 3     DNA-Apurinic Or Apyrimidinic Site Lyase2
OGG1 Type 1d1     N-Glycosylase/DNA Lyase2
OGG1 Type 1e1     OGG1 Type 1f2
OGG1 Type 1g1     MMH3
OGG1 Type 1h1     

External Ids:    HGNC: 81251   Entrez Gene: 49682   Ensembl: ENSG000001140267   OMIM: 6019825   UniProtKB: O155273   

Export aliases for OGG1 gene to outside databases

Previous GC identifers: GC03P009720 GC03P009782 GC03P009766 GC03P009767 GC03P009768 GC03P009769 GC03P009770 GC03P009771 GC03P009772 GC03P009773 GC03P009774 GC03P009727


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for OGG1 Gene:
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs
as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage.
Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type
1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and
type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial
targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene
have been described, but the full-length nature for every variant has not been determined. (provided by RefSeq,
Aug 2008)

GeneCards Summary for OGG1 Gene:
OGG1 (8-oxoguanine DNA glycosylase) is a protein-coding gene. Diseases associated with OGG1 include renal cell carcinoma, clear cell, somatic, and papillary adenoma. GO annotations related to this gene include microtubule binding and endonuclease activity.

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527
Function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and
2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks
DNA 3' to the lesion

Gene Wiki entry for OGG1 (Oxoguanine glycosylase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OGG1 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OGG1 promoter sequence
   Search Chromatin IP Primers for OGG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OGG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26.2   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p26

OGG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OGG1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P009791:  view genomic region     (about GC identifiers)

Start:
9,791,628 bp from pter      End:
9,829,903 bp from pter
Size:
38,276 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527 (See protein sequence)
Recommended Name: N-glycosylase/DNA lyase  
Size: 345 amino acids; 38782 Da
Sequence caution: Sequence=AAB84013.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for OGG1 (see all 27):
1EBM (3D)        1FN7 (3D)        1HU0 (3D)        1KO9 (3D)        1LWV (3D)        1LWW (3D)    
Secondary accessions: A8K1E3 O00390 O00670 O00705 O14876 O95488 P78554 Q9BW42 Q9UIK0 Q9UIK1
Q9UIK2 Q9UL34 Q9Y2C0 Q9Y2C1 Q9Y6C3 Q9Y6C4
Alternative splicing: 8 isoforms:  O15527-1   O15527-2   O15527-3   O15527-4   O15527-5   O15527-6   O15527-7   O15527-8   

Explore the universe of human proteins at neXtProt for OGG1: NX_O15527

Explore proteomics data for OGG1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OGG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_002533.1  NP_058212.1  NP_058213.1  NP_058214.1  NP_058434.1  NP_058436.1  NP_058437.1  NP_058438.1  

    ENSEMBL proteins: 
     ENSP00000305584   ENSP00000342851   ENSP00000306561   ENSP00000345520   ENSP00000403598  
     ENSP00000305527   ENSP00000396034   ENSP00000373337   ENSP00000390337   ENSP00000393726  
     ENSP00000399810   ENSP00000344899   ENSP00000402713   ENSP00000303132  
    Reactome Protein details: O15527

    OGG1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for OGG1
    OriGene Protein Over-expression Lysate for OGG1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for OGG1
    GenScript Custom Purified and Recombinant Proteins Services for OGG1
    Novus Biologicals OGG1 Proteins
    Novus Biologicals OGG1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for OGG1
    Cloud-Clone Corp. Proteins for OGG1

    OGG1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of OGG1
    Browse R&D Systems for Antibodies
    OriGene Antibodies for OGG1
    OriGene Custom Antibody Services for OGG1
    Novus Biologicals OGG1 Antibodies
    Search for Antibodies for OGG1 at Abcam
    Cloud-Clone Corp. Antibodies for OGG1
    ThermoFisher Antibody for OGG1
    LSBio Antibodies in human, mouse, rat for OGG1

    OGG1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OGG1
    R&D Systems DNA Damage/Repair Kits & Reagents for OGG1
    GenScript Custom Assay Services for OGG1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OGG1
    Cloud-Clone Corp. CLIAs for OGG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR023170 HTH_base_excis_C
     IPR011257 DNA_glycosylase
     IPR004577 Ogg
     IPR003265 HhH-GPD_domain
     IPR012904 OGG_N

    Graphical View of Domain Structure for InterPro Entry O15527

    ProtoNet protein and cluster: O15527

    1 Blocks protein domain: IPB012904 8-oxoguanine DNA glycosylase

    UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527
    Similarity: Belongs to the type-1 OGG1 family


    OGG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OGG1_HUMAN, O15527
    Function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and
    2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks
    DNA 3' to the lesion
    Catalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination
    reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate

         Genatlas biochemistry entry for OGG1:
    8oxo-7,8-dihydroxyguanine-DNA glycosylase/apurinic,apyrimidic lyase,mut M homolog,ubiquitously expressed with four
    alternatively spliced isoforms,yeast OGG1 ortholog,involved in the repair of oxidative DNA damage and in
    carcinogenesis

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding IEA--
    GO:0003824catalytic activity ----
    GO:0004519endonuclease activity TAS9223305
    GO:0005515protein binding IPI15518571
    GO:0008017microtubule binding IEA--
         
    OGG1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OGG1:
     Small cells 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ogg1):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  nervous system  normal  tumorigenesis 

    OGG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for OGG1: Ogg1tm1Tld Ogg1tm1Skmi Ogg1tm1Tno

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OGG1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OGG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OGG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OGG1

    miRNA
    Products:
        
    miRTarBase miRNAs that target OGG1:
    hsa-mir-615-3p (MIRT040345), hsa-mir-1260b (MIRT052750)

    Block miRNA regulation of human, mouse, rat OGG1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate OGG1:
    hsa-miR-33a* hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidOGG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OGG1
    Predesigned siRNA for gene silencing in human, mouse, rat OGG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OGG1

    Clone
    Products:
         
    OriGene clones in human, mouse for OGG1 (see all 46)
    OriGene ORF clones in mouse, rat for OGG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): OGG1 (NM_002542)
    Sino Biological Human cDNA Clone for OGG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OGG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGG1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OGG1
    Browse ESI BIO Cell Lines and PureStem Progenitors for OGG1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    OGG1_HUMAN, O15527: Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited
    to nuclear speckles in UVA-irradiated cells
    OGG1_HUMAN, O15527: Isoform 1A: Nucleus
    OGG1_HUMAN, O15527: Isoform 2A: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IEA--
    GO:0016363nuclear matrix IDA17148573

    OGG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for OGG1 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Resolution of Abasic Sites (AP sites)
    Resolution of Abasic Sites (AP sites)0.89
    Base Excision Repair0.00
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway0.89
    Displacement of DNA glycosylase by APE10.00
    Base excision repair0.53
    Resolution of AP sites via the single-nucleotide replacement pathway0.00
    Base-Excision Repair, AP Site Formation0.00
    Removal of DNA patch containing abasic residue0.00
    2Depurination
    Depurination
    Cleavage of the damaged purine0.00
    Recognition and association of DNA glycosylase with site containing an affected purine0.00
    3DNA Repair
    DNA Repair0.45
    4Chks in Checkpoint Regulation
    DNA Repair Mechanisms0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for OGG1
        DNA Repair Mechanisms


    3 Reactome Pathways for OGG1
        Displacement of DNA glycosylase by APE1
    Recognition and association of DNA glycosylase with site containing an affected purine
    Cleavage of the damaged purine


    1 Kegg Pathway  (Kegg details for OGG1):
        Base excision repair


    OGG1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OGG1: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OGG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OGG1 (O155271, 2, 3 ENSP000003065614) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XPCQ018312, 3, ENSP000002850214MINT-3292209 I2D: score=1 STRING: ENSP00000285021
    SNRPFP623061, 3, ENSP000002667354EBI-721675,EBI-356900 I2D: score=2 STRING: ENSP00000266735
    KPNA6O606843, ENSP000003627284I2D: score=3 STRING: ENSP00000362728
    KPNB1Q149743, ENSP000002901584I2D: score=3 STRING: ENSP00000290158
    MSH2P432463, ENSP000002331464I2D: score=1 STRING: ENSP00000233146
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000737DNA catabolic process, endonucleolytic TAS9190902
    GO:0002526acute inflammatory response IEA--
    GO:0006281DNA repair TAS--
    GO:0006284base-excision repair TAS--
    GO:0006285base-excision repair, AP site formation TAS--

    OGG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OGG1

    Selected Novoseek inferred chemical compound relationships for OGG1 gene (see all 61)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    8-oxoguanine 98.2 316 18578506 (4), 9197244 (3), 9207108 (3), 12841596 (3) (see all 99)
    8-hydroxyguanine 94 47 15551330 (3), 9681819 (2), 9765618 (2), 10329432 (1) (see all 39)
    8-oxo-dg 87 64 18218111 (4), 20040097 (3), 16364924 (3), 12187202 (2) (see all 39)
    formamidopyrimidine 82.6 9 17687444 (1), 10671534 (1), 10957965 (1), 12140329 (1) (see all 7)
    8-oxo-dgtp 79.6 3 20197241 (2), 9801308 (1)
    potassium bromate 76.3 3 20042377 (1), 16597659 (1), 16861056 (1)
    2,6-diamino-4-hydroxy-5-formamidopyrimidine 73.9 4 16478987 (1), 19674107 (1), 12627976 (1)
    guanine 73 23 19889642 (1), 20193742 (1), 1495996 (1), 19800894 (1) (see all 18)
    5-hydroxyuracil 72.8 1 11287425 (1)
    8-hydroxyadenine 71.8 6 9197244 (1), 9683192 (1), 18222119 (1)



    OGG1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for OGG1 gene (8 alternative transcripts): 
    NM_002542.5  NM_016819.3  NM_016820.3  NM_016821.2  NM_016826.2  NM_016827.2  NM_016828.2  NM_016829.2  

    Unigene Cluster for OGG1:

    8-oxoguanine DNA glycosylase
    Hs.380271  [show with all ESTs]
    Unigene Representative Sequence: NM_016828
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302003(uc003bsj.3 uc003bsr.2 uc010hcm.2 uc003bsq.2 uc003bsp.2)
    ENST00000344629(uc003bsi.3) ENST00000302036(uc003bsl.3 uc003bsk.3 uc003bsm.3 uc003bsn.3 uc003bso.3)
    ENST00000339511(uc003bsh.3) ENST00000436092 ENST00000449570 ENST00000302008
    ENST00000425665 ENST00000383826 ENST00000441094 ENST00000429146 ENST00000432857
    ENST00000426518 ENST00000352937 ENST00000383825 ENST00000416333 ENST00000602976
    ENST00000349503

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OGG1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate OGG1:
    hsa-miR-33a* hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidOGG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OGG1
    Predesigned siRNA for gene silencing in human, mouse, rat OGG1
    Clone
    Products:
         
    OriGene clones in human, mouse for OGG1 (see all 46)
    OriGene ORF clones in mouse, rat for OGG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): OGG1 (NM_002542)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OGG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGG1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OGG1
    OriGene qSTAR qPCR primer pairs in human, mouse for OGG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OGG1
      QuantiTect SYBR Green Assays in human, mouse, rat OGG1
      QuantiFast Probe-based Assays in human, mouse, rat OGG1

    Additional mRNA sequence: 

    AB000410.1 AB019528.1 AB019529.1 AB019530.1 AB019531.1 AB019532.1 AB037878.1 AB037879.1 
    AB037880.1 AB037881.1 AB037882.1 AF003595.1 AF026691.1 AK289858.1 BC000657.2 U88527.1 
    U88620.1 U96710.1 Y11731.2 Y11838.1 Y13277.1 

    17 DOTS entries:

    DT.92443605  DT.95254846  DT.97766475  DT.100827161  DT.100827171  DT.100827167  DT.95254849  DT.100827172 
    DT.92443604  DT.97824336  DT.95254860  DT.415770  DT.100652898  DT.95254858  DT.95254861  DT.99975679 
    DT.92024454 

    Selected AceView cDNA sequences (see all 242):

    AB037879 AI698716 BM975833 BI917794 BM835557 Y11838 BM461963 AL561104 
    AA814950 AW771934 AB037878 CD368085 BM783575 BM552418 U88620 BQ071115 
    BQ421238 AL547682 AL544748 AW263193 AF003595 CD366141 BQ894319 AI271701 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OGG1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
    SP1:                                                                                                      
    SP2:                          -                                                                           
    SP3:                                            -                                                         
    SP4:                                            -                       -     -                           
    SP5:                                            -                       -     -     -                     


    ECgene alternative splicing isoforms for OGG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    OGG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGGGAGGG
    OGG1 Expression
    About this image


    OGG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    OGG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OGG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380271

    UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OGG1: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for OGG1
    OriGene qSTAR qPCR primer pairs in human, mouse for OGG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OGG1
    QuantiTect SYBR Green Assays in human, mouse, rat OGG1
    QuantiFast Probe-based Assays in human, mouse, rat OGG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OGG1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ogg11 , 5 8-oxoguanine DNA-glycosylase 11, 5 84.25(n)1
    84.93(a)1
      6 (52.75 cM)5
    182941  NM_010957.41  NP_035087.31 
     1133269725 
    chicken
    (Gallus gallus)
    Aves OGG11 8-oxoguanine DNA glycosylase 61.76(n)
    57.68(a)
      771001  NM_001277838.1  NP_001264767.1 
    lizard
    (Anolis carolinensis)
    Reptilia OGG16
    8-oxoguanine DNA glycosylase
    53(a)
    1 ↔ 1
    2(191168349-191180714)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ogg11 8-oxoguanine DNA glycosylase 59.72(n)
    57.4(a)
      100380072  XM_004914114.1  XP_004914171.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ogg11 8-oxoguanine DNA glycosylase 58.36(n)
    57.1(a)
      791194  NM_001123308.2  NP_001116780.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ogg11 , 3 DNA repair DNA-(apurinic or
    apyrimidinic site) more3
    Ogg11
    36(a)3
    45.81(n)1
    37.09(a)1
      8A23
    318061  NM_132271.51  NP_572499.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OGG1(YML060W)4
    OGG11
    Mitochondrial glycosylase/lyase that specifically excises more4
    OGG11
    47.44(n)1
    41.64(a)1
      13(151871-153001)4
    8549421, 4  NP_013651.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons OGG11 OGG1 48.07(n)
    42.24(a)
      838775  NM_102020.3  NP_173590.1 


    ENSEMBL Gene Tree for OGG1 (if available)
    TreeFam Gene Tree for OGG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for OGG1 gene
    3 SIMAP similar genes for OGG1 using alignment to 14 protein entries:     OGG1_HUMAN (see all proteins):
    OGG1 type 1e    OGG1 type 1f    OGG1 type 1g

    OGG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for OGG1 (see all 584)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048937511,2,,4
    C,Fother19726809(+) TTTCCG/AGTGAG 16 /Q /R mis12Minor allele frequency- A:0.00NA EU 5847
    rs1591531,2
    C,F,A,H--9724577(+) CTGTGT/CTGAGC 8 -- us2k129Minor allele frequency- C:0.30MN NS EA NA WA CSA 3300
    rs32189931,2
    C,F--9724605(+) tttgcG/Ataatc 8 -- us2k11Minor allele frequency- A:0.01NS 170
    rs1837626141,2
    --9724617(+) TTGCAA/GTAACT 8 -- us2k10--------
    rs561109561,2
    C--9724623(+) TAACTA/GTAGGG 8 -- us2k10--------
    rs415506121,2
    C--9724744(+) CTGTTG/TGCAAA 8 -- us2k10--------
    rs32189951,2
    C,F--9725162(+) GGCTGG/AGACAC 8 -- us2k13Minor allele frequency- A:0.03NS WA NA 418
    rs1257011,2
    C,F,O,A,H--9725180(+) AATCCG/ACTGCA 8 -- us2k128Minor allele frequency- A:0.06NS EA NA 3336
    rs1450282871,2
    --9725198(+) CTCTTC/GAAGAA 8 -- us2k10--------
    rs1926460561,2
    C--9725223(+) GGGGTA/GCGGTG 8 -- us2k10--------

    HapMap Linkage Disequilibrium report for OGG1 (9791628 - 9829903 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OGG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821982CNV Gain20364138

    Human Gene Mutation Database (HGMD): OGG1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OGG1
    DNA2.0 Custom Variant and Variant Library Synthesis for OGG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601982   
    OMIM disorders: 144700  
    UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527
  • Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or
    hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear
    cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma,
    collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear
    cell renal cell carcinoma is the most common subtype. Note=The disease may be caused by mutations affecting the
    gene represented in this entry

  • Selected diseases for OGG1 (see all 113):    
    About MalaCards
    renal cell carcinoma, clear cell, somatic    papillary adenoma    xeroderma pigmentosum, group f    attenuated familial adenomatous polyposis
    familial adenomatous polyposis    lung cancer susceptibility    asbestosis    cockayne syndrome
    pneumoconiosis    cholangiocarcinoma    collecting duct carcinoma    acoustic neuroma
    barrett esophagus/esophageal adenocarcinoma    pterygium    xeroderma pigmentosum    gallbladder cancer
    neuroma    lynch syndrome    renal cell carcinoma    barrett's adenocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for OGG1:
    Lung cancer     Cockayne syndrome     Xeroderma pigmentosum

    OGG1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for OGG1 gene (see all 47)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    group b cockayne syndrome 66.7 1 12531019 (1)
    cancer lung 58.9 72 18234257 (4), 9681819 (3), 19671832 (3), 18628426 (3) (see all 30)
    adenocarcinoma lung 56.1 9 11911490 (1), 17294717 (1), 18338377 (1), 19535000 (1) (see all 5)
    cancer 55.9 52 17389610 (4), 15584022 (3), 17651912 (2), 15870915 (2) (see all 41)
    xeroderma pigmentosum 52.7 7 12187202 (2), 20101267 (1), 18349297 (1), 19561388 (1) (see all 5)
    allelic imbalance 39.6 5 12527710 (1), 12378519 (1), 16211227 (1), 11598155 (1)
    somatic mutations 39.4 11 11295288 (2), 16211227 (2), 11465542 (2), 11239755 (1) (see all 7)
    germ-line mutation 34.3 2 16771692 (1)
    polyposis 31 1 18515411 (1)
    allelic loss 29.9 13 15870915 (8), 11598155 (2)

    Genetic Association Database (GAD): OGG1
    Human Genome Epidemiology (HuGE) Navigator: OGG1 (236 documents)

    Export disorders for OGG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for OGG1 gene, integrated from 10 sources (see all 709):
    (articles sorted by number of sources associating them with OGG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. (PubMed id 9207108)1, 2, 3, 9 Rosenquist T.A.... Grollman A.P. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Structure and chromosome location of human OGG1. (PubMed id 10449904)1, 2, 3 Ishida T.... Aburatani H. (Cytogenet. Cell Genet. 1999)
    3. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. (PubMed id 9187114)1, 2, 9 Aburatani H.... Nishimura S. (Cancer Res. 1997)
    4. OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study. (PubMed id 18155253)1, 4, 9 Hatt L....Vogel U. (Mutat. Res. 2008)
    5. Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. (PubMed id 18515411)1, 4, 9 Dallosso A.R....Sampson J.R. (Gut 2008)
    6. Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations? (PubMed id 15491645)1, 4, 9 Aka P....Kirsch-Volders M. (Mutat. Res. 2004)
    7. Genetic polymorphisms in OGG1 and their association with angiomyolipoma, a benign kidney tumor in patients with tuberous sclerosis. (PubMed id 17932460)1, 4, 9 Habib S.L....Thameem F. (amp 2008)
    8. Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. (PubMed id 9223305)1, 2, 9 Radicella J.P.... Boiteux S. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    9. Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers. (PubMed id 19563869)1, 4, 9 Manini P....Vodicka P. (Toxicol. Lett. 2009)
    10. Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours. (PubMed id 9662341)1, 2, 9 Chevillard S.... Boiteux S. (Oncogene 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4968 HGNC: 8125 AceView: OGG1 Ensembl:ENSG00000114026 euGenes: HUgn4968
    ECgene: OGG1 Kegg: 4968 H-InvDB: OGG1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for OGG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OGG1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ogg1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for OGG1 gene:
    Search GeneIP for patents involving OGG1

    Licensable Technologies for OGG1 gene:
    Weizmann Institute:Human DNA Repair In Medical Diagnostics
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of OGG1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     DNA Damage/Repair Kits/Reagents for OGG1 (OGG1)   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for OGG1   OriGene RNAi products in human, mouse, rat for OGG1  
     OriGene qPCR primer pairs and template standards for OGG1   OriGene Protein Over-expression Lysate for OGG1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for OGG1  
     OriGene qSTAR qPCR primer pairs in human, mouse for OGG1   OriGene Purified Protein for OGG1  
     OriGene ORF clones in mouse, rat for OGG1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OGG1   OriGene Custom Protein Services for OGG1  

     
     
     Block miRNA regulation of human, mouse, rat OGG1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OGG1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OGG1 Predesigned siRNA for gene silencing in human, mouse, rat OGG1
     QuantiFast Probe-based Assays in human, mouse, rat OGG1 QuantiTect SYBR Green Assays in human, mouse, rat OGG1
     PCR Arrays including human, mouse, rat OGG1 Search Chromatin IP Primers for OGG1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OGG1  GeneGlobe Interaction Network for OGG1
     Regulatory tfbs in OGG1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for OGG1 GenScript cDNA clones with any tag delivered in your preferred vector for OGG1
     GenScript Custom Assay Services for OGG1 GenScript Custom overexpressing Cell Line Services for OGG1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for OGG1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for OGG1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     OGG1 antibodies
     OGG1 proteins
     OGG1 lysates
     Search for Antibodies for OGG1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for OGG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for OGG1
     Proteins for OGG1
     Antibodies for OGG1
     ELISAs for OGG1
     CLIAs for OGG1



     Browse ESI BIO Cell Lines and PureStem Progenitors for OGG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGG1
     SwitchGear 3'UTR luciferase reporter plasmids for OGG1
     SwitchGear Promoter luciferase reporter plasmids for OGG1
     ThermoFisher Antibody for OGG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGG1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OGG1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OGG1
     LSBio Antibodies in human, mouse, rat for OGG1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OGG1 gene at Home site.
    Version: 3.12.158 12 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4