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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OGG1 Gene

protein-coding GIFtS: 70
GCID: GC03P009791

8-oxoguanine DNA glycosylase

Explore 117 diseases affiliated with
OGG1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
8-Oxoguanine DNA Glycosylase¹ ²		AP Lyase²
MUTM¹ ² ³		DNA-Apurinic Or Apyrimidinic Site Lyase²
OGH1¹ ² ³		N-Glycosylase/DNA Lyase²
HMMH¹ ²		OGG1 Type 1f²
HOGG1¹ ²		MMH³
8-Hydroxyguanine DNA Glycosylase²

External Ids:	HGNC: 8125¹	Entrez Gene: 4968²	Ensembl: ENSG00000114026⁷	OMIM: 601982⁵	UniProtKB: O15527³

Export aliases for OGG1 gene to outside databases

Previous GC identifers: GC03P009720 GC03P009782 GC03P009766 GC03P009767 GC03P009768 GC03P009769 GC03P009770 GC03P009771 GC03P009772 GC03P009773 GC03P009774 GC03P009727

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OGG1:

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a

result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage.

Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1

and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2

end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal

that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described,

but the full-length nature for every variant has not been determined. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527

Function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and

2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA

3' to the lesion

Gene Wiki entry for OGG1 (Oxoguanine glycosylase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OGG1 gene promoter:
PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OGG1 promoter sequence

Search SABiosciences Chromatin IP Primers for OGG1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OGG1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26.2 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p26

OGG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OGG1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P009791: view genomic region (about GC identifiers)

Start:	9,791,628 bp from pter	End:	9,829,903 bp from pter
Size:	38,276 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527 (See protein sequence)

Recommended Name: N-glycosylase/DNA lyase

Size: 345 amino acids; 38782 Da

Subcellular location: Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited to

nuclear speckles in UVA-irradiated cells

Subcellular location: Isoform 1A: Nucleus

Subcellular location: Isoform 2A: Mitochondrion

Sequence caution: Sequence=AAB84013.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

6/27 PDB 3D structures from and Proteopedia for OGG1 (see all 27):

1EBM (3D)

1FN7 (3D)

1HU0 (3D)

1KO9 (3D)

1LWV (3D)

1LWW (3D)

Secondary accessions: A8K1E3 O00390 O00670 O00705 O14876 O95488 P78554 Q9BW42 Q9UIK0 Q9UIK1 Q9UIK2

Q9UL34 Q9Y2C0 Q9Y2C1 Q9Y6C3 Q9Y6C4

Alternative splicing: 8 isoforms: O15527-1 O15527-2 O15527-3 O15527-4 O15527-5 O15527-6 O15527-7 O15527-8

Explore the universe of human proteins at neXtProt for OGG1: NX_O15527

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15527

OGG1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (8 alternative transcripts):

NP_002533.1 NP_058212.1 NP_058213.1 NP_058214.1 NP_058434.1 NP_058436.1 NP_058437.1 NP_058438.1

ENSEMBL proteins:

ENSP00000305584 ENSP00000342851 ENSP00000306561 ENSP00000345520 ENSP00000403598

ENSP00000305527 ENSP00000396034 ENSP00000373337 ENSP00000390337 ENSP00000393726

ENSP00000399810 ENSP00000344899 ENSP00000402713 ENSP00000303132

Reactome Protein details: O15527
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	Uscn Proteins for OGG1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	IEA	--

OGG1 for ontologies About GeneDecksing

OGG1 Antibody Products:

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	ThermoFisher Antibody for OGG1

Assay Products for OGG1:

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	R&D Systems DNA Damage/Repair Kits & Reagents for OGG1
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for OGG1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OGG1 for domains About GeneDecksing

5 InterPro domains/families:

IPR023170 HTH_base_excis_C

IPR011257 DNA_glycosylase

IPR004577 Ogg

IPR003265 HhH-GPD_domain

IPR012904 OGG_N

Graphical View of Domain Structure for InterPro Entry O15527

ProtoNet protein and cluster: O15527

1 Blocks protein family: IPB012904 8-oxoguanine DNA glycosylase

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527

Similarity: Belongs to the type-1 OGG1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527

Function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and

2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA

3' to the lesion

Catalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination

reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate

Genatlas biochemistry entry for OGG1:

8oxo-7,8-dihydroxyguanine-DNA glycosylase/apurinic,apyrimidic lyase,mut M homolog,ubiquitously expressed with four

alternatively spliced isoforms,yeast OGG1 ortholog,involved in the repair of oxidative DNA damage and in

carcinogenesis

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		hsa-miR-33a* hsa-miR-138-2*
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGG1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003684	damaged DNA binding	IEA	--
GO:0004519	endonuclease activity	TAS	9223305
GO:0005515	protein binding	IPI	15518571
GO:0008017	microtubule binding	IEA	--
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	TAS	9190902

OGG1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for OGG1:

Small cells

Animal Models:
Mouse knock-outs for OGG1: Ogg1^tm1Tld Ogg1^tm1Skmi Ogg1^tm1Tno
6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ogg1):

cellular	homeostasis/metabolism	liver/biliary system	mortality/aging	normal
tumorigenesis

OGG1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Base-Excision Repair, AP Site Formation

Base-Excision Repair, AP Site Formation	1.00	Depurination	0.38
Displacement of DNA glycosylase by APE1	0.89	Recognition and association of DNA glycosylase with site containing an affected purine	0.38
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway	0.80	Cleavage of the damaged purine	0.38
Resolution of AP sites via the single-nucleotide replacement pathway	0.67

Resolution of Abasic Sites (AP sites)

Resolution of Abasic Sites (AP sites)	1.00	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.89
Base Excision Repair	1.00	Base excision repair	0.51
Removal of DNA patch containing abasic residue	0.89

Nucleotide Excision Repair

DNA Repair

0.46

Chks in Checkpoint Regulation

DNA Repair Mechanisms

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for OGG1

DNA Repair Mechanisms

5/12 Reactome Pathways for OGG1 (see all 12)

	Removal of DNA patch containing abasic residue
	DNA Repair
	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
	Base-Excision Repair, AP Site Formation
	Base Excision Repair

1 Kegg Pathway (Kegg details for OGG1):

Base excision repair

OGG1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for OGG1

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/31 Interacting proteins for OGG1 (O15527^{1, 2, 3} ENSP00000306561⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SNRPF	P62306¹^,³, ENSP00000266735⁴	EBI-721675,EBI-356900 I2D: score=2 STRING: ENSP00000266735
XPC	Q01831²^,³, ENSP00000285021⁴	MINT-3292209 I2D: score=1 STRING: ENSP00000285021
KPNB1	Q14974³, ENSP00000290158⁴	I2D: score=3 STRING: ENSP00000290158
GTF2H2C	Q6P1K8³	I2D: score=1
GTF2H2D	Q6P1K8³	I2D: score=1

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002526	acute inflammatory response	IEA	--
GO:0006281	DNA repair	TAS	--
GO:0006284	base-excision repair	TAS	--
GO:0006285	base-excision repair, AP site formation	TAS	--
GO:0006289	nucleotide-excision repair	IEA	--

OGG1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

OGG1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OGG1
10/61 Novoseek chemical compound relationships for OGG1 gene (see all 61) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
8-oxoguanine	98.2	316	18578506 (4), 9197244 (3), 9207108 (3), 12841596 (3) (see all 99)
8-hydroxyguanine	94	47	15551330 (3), 9681819 (2), 9765618 (2), 10329432 (1) (see all 39)
8-oxo-dg	87	64	18218111 (4), 20040097 (3), 16364924 (3), 12187202 (2) (see all 39)
formamidopyrimidine	82.6	9	17687444 (1), 10671534 (1), 10957965 (1), 12140329 (1) (see all 7)
8-oxo-dgtp	79.6	3	20197241 (2), 9801308 (1)
potassium bromate	76.3	3	20042377 (1), 16597659 (1), 16861056 (1)
2,6-diamino-4-hydroxy-5-formamidopyrimidine	73.9	4	16478987 (1), 19674107 (1), 12627976 (1)
guanine	73	23	19889642 (1), 20193742 (1), 1495996 (1), 19800894 (1) (see all 18)
5-hydroxyuracil	72.8	1	11287425 (1)
8-hydroxyadenine	71.8	6	9197244 (1), 9683192 (1), 18222119 (1)

Search CenterWatch for drugs/clinical trials and news about OGG1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OGG1 gene (8 alternative transcripts):

NM_002542.5 NM_016819.3 NM_016820.3 NM_016821.2 NM_016826.2 NM_016827.2 NM_016828.2 NM_016829.2

Unigene Cluster for OGG1:

8-oxoguanine DNA glycosylase

Hs.380271 [show with all ESTs]

Unigene Representative Sequence: NM_016828

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302003(uc003bsj.3 uc003bsr.2 uc010hcm.2 uc003bsq.2 uc003bsp.2)

ENST00000344629(uc003bsi.3) ENST00000302036(uc003bsl.3 uc003bsk.3 uc003bsm.3 uc003bsn.3 uc003bso.3)

ENST00000339511(uc003bsh.3) ENST00000436092 ENST00000449570 ENST00000302008

ENST00000425665 ENST00000383826 ENST00000441094 ENST00000429146 ENST00000432857

ENST00000426518 ENST00000352937 ENST00000383825 ENST00000416333 ENST00000349503

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Additional cDNA sequence:

AB000410.1 AB019528.1 AB019529.1 AB019530.1 AB019531.1 AB019532.1 AB037878.1 AB037879.1

AB037880.1 AB037881.1 AB037882.1 AF003595.1 AF026691.1 AK289858.1 BC000657.2 U88527.1

U88620.1 U96710.1 Y11731.2 Y11838.1 Y13277.1

17 DOTS entries:

DT.92443605 DT.95254846 DT.97766475 DT.100827161 DT.100827171 DT.100827167 DT.95254849 DT.100827172

DT.92443604 DT.97824336 DT.95254860 DT.415770 DT.100652898 DT.95254858 DT.95254861 DT.99975679

DT.92024454

24/242 AceView cDNA sequences (see all 242):

BU527387 AI698716 AB037880 AL599058 AB019528 AI274086 CR597017 CD366141

BM682210 AA983771 BQ773840 AB037882 AL528404 BM839723 BQ421238 AA814743

AB019532 CR603924 Y11838 AW771934 AL542650 AB019529 BM723347 AF003595

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for OGG1 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	·	7d
SP1:
SP2:									-
SP3:															-
SP4:															-								-		-
SP5:															-								-		-		-

ECgene alternative splicing isoforms for OGG1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OGG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGGGAGGG

About this image
See OGG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OGG1

SOURCE GeneReport for Unigene cluster: Hs.380271

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Arrays including OGG1:

DNA Damage Signaling Pathway in human mouse rat

DNA Repair in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for OGG1 gene from 7/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ogg1^{1 , 5}	8-oxoguanine DNA-glycosylase 1^{1, 5}	84.6(n)¹ 85.38(a)¹		6 (52.75 cM)⁵ 18294¹ NM_010957.4¹ NP_035087.3¹ 113326972⁵
chicken (Gallus gallus)	Aves	OGG1¹	8-oxoguanine DNA glycosylase	62.07(n) 57.99(a)		771001 XM_001234322.2 XP_001234323.2
lizard (Anolis carolinensis)	Reptilia	OGG1⁶	--	52(a)	1 ↔ 1	2(191168413-191180696)
zebrafish (Danio rerio)	Actinopterygii	ogg1¹	8-oxoguanine DNA glycosylase	58.36(n) 57.1(a)		791194 NM_001123308.2 NP_001116780.1
fruit fly (Drosophila melanogaster)	Insecta	Ogg1^{1 , 3}	DNA repair DNA-(apurinic or apyrimidinic site) more³ CG1795-PA¹	36(a)³ 45.92(n)¹ 37.09(a)¹		8A2³ 31806¹ NM_132271.4¹ NP_572499.2¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	OGG1(YML060W)⁴ OGG1¹	Mitochondrial glycosylase/lyase that specifically excises more⁴ Ogg1p¹	47.79(n)¹ 42.66(a)¹		13(151871-153001)⁴ 854942^{1, 4} NP_013651.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	OGG1¹	8-oxoguanine-DNA glycosylase 1	48.18(n) 41.91(a)		838775 NM_102020.3 NP_173590.1

ENSEMBL Gene Tree for OGG1 (if available)
TreeFam Gene Tree for OGG1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104893751^1,2	C,F,	other	10956412(+)	`TTTCCG/AGTGAG`	16	/Q /R	mis¹		2		NA EU	5847
rs3218993^1,2	C,	--	9726250(+)	`tttgcG/Ataatc`	8	--	us2k¹		1		NS	170
rs41550612^1,2	C,	--	9726389(+)	`CTGTTG/TGCAAA`	8	--	us2k¹		0	--	--	--	--
rs3218995^1,2	C,F,	--	9726807(+)	`GGCTGG/AGACAC`	8	--	us2k¹		3		NS WA NA	418
rs3218996^1,2	C,F,A,	--	9726877(+)	`tggctC/Tacgcc`	8	--	us2k¹		3		NS CSA NA	300
rs41554519^1,2	C	--	9727094(+)	`GAGATC/TGCGCC`	8	--	us2k¹		1		CSA	2
rs28565256^1,2		--	9727324(+)	`CTGCCC/TCAGGG`	8	--	us2k¹ ese³		0	--	--	--	--
rs3218997^1,2	C,F,	--	9727691(+)	`TAAGAC/TTGCAA`	8	--	us2k¹ ese³		8		NS NA	300
rs28378877^1,2		--	9727859(+)	`CCCAGA/TGCCGG`	8	--	us2k¹ ese³		0	--	--	--	--
rs3218999^1,2	C,F,	--	9728038(+)	`CGCCCA/GCAGGC`	8	--	ut5¹ ese³		2		NS WA	288

HapMap Linkage Disequilibrium report for OGG1 (9791628 - 9829903 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OGG1: --
Human Gene Mutation Database (HGMD): OGG1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OGG1

DNA2.0 Custom Variant and Variant Library Synthesis for OGG1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OGG1 for disorders           About GeneDecksing

OMIM gene information: 601982
OMIM disorders: 144700
UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527

Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of

sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into

clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell

carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma

20/117 diseases for OGG1 (see all 117): About MalaCards

xeroderma pigmentosum, group f renal cell carcinoma, clear cell, somatic familial adenomatous polyposis attenuated familial adenomatous polyposis

xeroderma pigmentosum age related macular degeneration graft versus host disease non-small cell lung carcinoma

collecting duct carcinoma renal cell carcinoma acoustic neuroma non-hodgkin lymphoma

squamous cell carcinoma chromophobe renal cell carcinoma type 2 diabetes mellitus spina bifida

atrophic gastritis macular degeneration orofacial cleft amyotrophic lateral sclerosis

3 diseases from the University of Copenhagen DISEASES database for OGG1:

Lung cancer Cockayne syndrome Xeroderma pigmentosum

10/47 Novoseek disease relationships for OGG1 gene (see all 47) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
group b cockayne syndrome	66.7	1	12531019 (1)
cancer lung	58.9	72	18234257 (4), 9681819 (3), 19671832 (3), 18628426 (3) (see all 30)
adenocarcinoma lung	56.1	9	11911490 (1), 17294717 (1), 18338377 (1), 19535000 (1) (see all 5)
cancer	55.9	52	17389610 (4), 15584022 (3), 17651912 (2), 15870915 (2) (see all 41)
xeroderma pigmentosum	52.7	7	12187202 (2), 20101267 (1), 18349297 (1), 19561388 (1) (see all 5)
allelic imbalance	39.6	5	12527710 (1), 12378519 (1), 16211227 (1), 11598155 (1)
somatic mutations	39.4	11	11295288 (2), 16211227 (2), 11465542 (2), 11239755 (1) (see all 7)
germ-line mutation	34.3	2	16771692 (1)
polyposis	31	1	18515411 (1)
allelic loss	29.9	13	15870915 (8), 11598155 (2)

Genetic Association Database (GAD): OGG1
Human Genome Epidemiology (HuGE) Navigator: OGG1 (236 documents)

Export disorders for OGG1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OGG1 gene, integrated from 9 sources (see all 660):
(articles sorted by number of sources associating them with OGG1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. (PubMed id 9207108)^{1, 2, 3, 9} Rosenquist T.A.... Grollman A.P. (1997)
Structure and chromosome location of human OGG1. (PubMed id 10449904)^{1, 2, 3} Ishida T.... Aburatani H. (1999)
Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. (PubMed id 9187114)^{1, 2, 9} Aburatani H.... Nishimura S. (1997)
Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations? (PubMed id 15491645)^{1, 4, 9} Aka P....Kirsch-Volders M. (2004)
Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. (PubMed id 9223305)^{1, 2, 9} Radicella J.P.... Boiteux S. (1997)
Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours. (PubMed id 9662341)^{1, 2, 9} Chevillard S.... Boiteux S. (1998)
Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. (PubMed id 17114185)^{1, 2, 9} Radom C.T.... Verdine G.L. (2007)
Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer. (PubMed id 14634453)^{1, 4, 9} Chen L....Park J. (2003)
A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer. (PubMed id 9197244)^{1, 2, 9} Lu R.... Verdine G.L. (1997)
Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients. (PubMed id 15449173)^{1, 4, 9} Kim I.J....Park J.G. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4968	HGNC: 8125	AceView: OGG1	Ensembl:ENSG00000114026	euGenes: HUgn4968
ECgene: OGG1	Kegg: 4968	H-InvDB: OGG1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for OGG1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for OGG1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ogg1/

Intellectual Property for OGG1 gene
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Patent Information for OGG1 gene:
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Licensable Technologies for OGG1 gene:

Weizmann Institute:

Human DNA Repair In Medical Diagnostics

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8-oxoguanine DNA glycosylase

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OGG1 Gene

8-oxoguanine DNA glycosylase

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