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OGG1 Gene

protein-coding GIFtS: 74

GC03P009773

8-oxoguanine DNA glycosylase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HMMH ^¹, ²
HOGG1 ^¹, ²
MMH ^³
MUTM ^¹, ², ³
OGH1 ^¹, ², ³
OTTHUMP00000122619 ^²

Descriptions
8-hydroxyguanine DNA glycosylase ^²
8-oxoguanine DNA glycosylase ^²
8-oxoguanine DNA-glycosylase 1 ^²
AP lyase ^²
DNA-apurinic or apyrimidinic site lyase ^²

External Ids
HGNC: 8125¹
Entrez Gene: 4968²
UniProtKB: O15527³
Ensembl: ENSG00000114026⁷

Search outside databases for aliases for OGG1 gene

Previous GC identifers: GC03P009720 GC03P009782 GC03P009766 GC03P009767 GC03P009768 GC03P009769 GC03P009770 GC03P009771 GC03P009772

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OGG1:

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base

byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme

includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this

gene classifies splice variants into two major groups, type 1 and type 2, depending on the last

exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon

8. All variants share the N-terminal region in common, which contains a mitochondrial targeting

signal that is essential for mitochondrial localization. Many alternative splice variants for this

gene have been described, but the full-length nature for every variant has not been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527

Function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine

and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase

activity that nicks DNA 3' to the lesion

Gene Wiki entry for OGG1 (Oxoguanine_glycosylase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OGG1 gene

Entrez Gene cytogenetic band: 3p26.2 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p26

OGG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P009773: (about GC identifiers)

Start:	9,765,705 bp from pter
End:	9,783,421 bp from pter
Size:	17,717 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527 (See protein sequence)

Recommended Name: N-glycosylase/DNA lyase

Size: 345 amino acids; 38782 Da

Subcellular location: Isoform 1A: Nucleus

Subcellular location: Isoform 2A: Mitochondrion

PDB structures from and Proteopedia :

1EBM (3D)

1FN7 (3D)

1HU0 (3D)

1KO9 (3D)

1LWV (3D)

1LWW (3D)

1LWY (3D)

1M3H (3D)

1M3Q (3D)

1N39 (3D)

1N3A (3D)

1N3C (3D)

1YQK (3D)

1YQL (3D)

1YQM (3D)

1YQR (3D)

2I5W (3D)

2NOB (3D)

2NOE (3D)

2NOF (3D)

2NOH (3D)

2NOI (3D)

2NOL (3D)

2NOZ (3D)

Secondary accessions: A8K1E3 O00390 O00670 O00705 O14876 O95488 P78554 Q9BW42 Q9UIK0 Q9UIK1 Q9UIK2

Q9UL34 Q9Y2C0 Q9Y2C1 Q9Y6C3 Q9Y6C4

Alternative splicing: 8 isoforms: O15527-1 O15527-2 O15527-3 O15527-4 O15527-5 O15527-6 O15527-7 O15527-8

REFSEQ proteins (8 alternative transcripts):

NP_002533.1 NP_058212.1 NP_058213.1 NP_058214.1 NP_058434.1 NP_058436.1 NP_058437.1 NP_058438.1

ENSEMBL proteins:

ENSP00000341434 ENSP00000373336 ENSP00000344899 ENSP00000345520 ENSP00000352791 ENSP00000342851

ENSP00000305584 ENSP00000305527 ENSP00000373337 ENSP00000303132 ENSP00000306561

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Ogg1)
	Human Recombinant Proteins from Abnova (OGG1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	TAS	9223305
GO:0005739	mitochondrion	IEA	--

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Antibodies for OGG1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of OGG1
	Sigma-Aldrich Antibodies for OGG1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Ogg1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for OGG1

Assays for OGG1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15527

ProtoNet protein and cluster: O15527

1 Blocks protein family: IPB012904 8-oxoguanine DNA glycosylase

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527

Similarity: Belongs to the type-1 OGG1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OGG1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OGG1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_016819

Applied Biosystems Silencer® siRNAs for OGG1

Sigma-Aldrich siRNA and siRNA Panels for OGG1

Sigma-Aldrich shRNA for OGG1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OGG1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 8): NM_002542
Myc/DDK tagged cDNA clones in CMV expression vector (see all 8): NM_002542
untagged cDNA clones in CMV expression vector (see all 9): NM_002542

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016821

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527

Function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine

and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase

activity that nicks DNA 3' to the lesion

Catalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a

beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal

5'-phosphate

Genatlas biochemistry entry for OGG1:

8oxo-7,8-dihydroxyguanine-DNA glycosylase/apurinic,apyrimidic lyase,mut M homolog,ubiquitously

expressed with four alternatively spliced isoforms,yeast OGG1 ortholog,involved in the repair of

oxidative DNA damage and in carcinogenesis

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ogg1):

cellular	homeostasis/metabolism	life span-post-weaning/aging	liver/biliary system	normal
tumorigenesis

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003684	damaged DNA binding	TAS	9223305
GO:0004519	endonuclease activity	TAS	9223305
GO:0005515	protein binding	IPI	15518571
GO:0008534	oxidized purine base lesion DNA N-glycosylase activity	TAS	9190902
GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for OGG1

5/45 Interacting proteins for OGG1 (ENSP00000306561³ O15527^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 45 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XPC	Q01831²	STRING (score=.907) MINT-3292209
SNRPF	P62306¹	EBI-721675, EBI-356900
APEX1	ENSP00000216714³	STRING (score=.98)
NTHL1	ENSP00000219066³	STRING (score=.944)
NEIL2	ENSP00000346591³	STRING (score=.94)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006284	base-excision repair	TAS	9190902
GO:0006289	nucleotide-excision repair	IEA	--
GO:0006974	response to DNA damage stimulus	IEA	--
GO:0008152	metabolic process	IEA	--
GO:0045007	depurination	EXP	10583946

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OGG1
10/43 Novoseek chemical compound relationships for OGG1 gene (see all 43 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
8-oxoguanine	98.01	267	18578506 (4), 9197244 (3), 9207108 (3), 12841596 (3) (see all 99)
8-hydroxyguanine	94.32	46	15551330 (3), 9681819 (2), 9765618 (2), 10329432 (1) (see all 38)
8-oxo-dg	86.35	56	18218111 (4), 16364924 (3), 12187202 (2), 15929986 (2) (see all 36)
formamidopyrimidine	82.96	8	17687444 (1), 10671534 (1), 10957965 (1), 12140329 (1) (see all 6)
8-oxo-dgtp	79.34	1	9801308 (1)
5-hydroxyuracil	74.24	1	11287425 (1)
8-hydroxyadenine	73.35	6	9197244 (1), 9683192 (1), 18222119 (1)
8-bromoguanine	73.31	3	16024742 (1), 17090545 (1)
fapygua	72.43	2	16478987 (1), 12627976 (1)
thymine glycol	72.23	1	11287425 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OGG1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OGG1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_016819

Sigma-Aldrich siRNA and siRNA Panels for OGG1

Sigma-Aldrich shRNA for OGG1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002542 NM_016819 NM_016820 NM_016821 NM_016826 NM_016827 NM_016828 NM_016829

REFSEQ mRNAs for OGG1 gene (8 alternative transcripts):

NM_002542.5 NM_016819.3 NM_016820.3 NM_016821.2 NM_016826.2 NM_016827.2 NM_016828.2 NM_016829.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002542 NM_016819 NM_016820 NM_016821 NM_016826 NM_016827 NM_016828 NM_016829

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 8): NM_002542
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 8): NM_002542
                                 untagged cDNA clones in CMV expression vector (see all 9): NM_002542

Additional cDNA sequence:

AB000410.1 AB019528.1 AB019529.1 AB019530.1 AB019531.1 AB019532.1 AB037878.1 AB037879.1

AB037880.1 AB037881.1 AB037882.1 AF003595.1 AF026691.1 AK289858.1 BC000657.2 CR591637.1

CR597017.1 CR603924.1 CR610319.1 CR611650.1 CR616161.1 CR618090.1 U88527.1 U88620.1

U96710.1 Y11731.2 Y11838.1 Y13277.1

17 DOTS entries:

DT.92443605 DT.95254846 DT.97766475 DT.100827161 DT.100827167 DT.100827171 DT.95254849 DT.97824336

DT.100827172 DT.92443604 DT.415770 DT.95254860 DT.100652898 DT.92024454 DT.95254858 DT.95254861

DT.99975679

24/242 AceView cDNA sequences (see all 242 ):

CA310225 CR611650 CR591637 AF003595 AB037878 BM461963 BM682210 CR610319

BC000657 BM723347 BU527387 AA018430 AB037882 NM_016820 BU521060 BQ773840

AL547682 CD366141 BM835557 AW772517 AB037881 BM552418 AI274086 AL556111

highest scoring ESTs for OGG1:

AB019529 U88620 AA521026 AA657398 AA961481 AB019528 AB019530 AB019531 AI056495 AI223823

Unigene Cluster for OGG1:

8-oxoguanine DNA glycosylase

Hs.380271 [show with all ESTs]

Unigene Representative Sequence: NM_016828

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for OGG1 (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	·	7d
SP1:
SP2:									-
SP3:															-
SP4:															-								-		-
SP5:															-								-		-		-

About this scheme

ECgene alternative splicing isoforms for OGG1

11 Ensembl transcripts including schematic representations:

ENST00000339542 ENST00000383825 ENST00000352937 ENST00000339511 ENST00000359753 ENST00000344629

ENST00000302003 ENST00000302008 ENST00000383826 ENST00000349503 ENST00000302036

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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OGG1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OGG1

¹ / ² / ³

9 probe-sets matching OGG1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34147_g_at²^{, 3}	U95-A	1	1.00	1.00	0.68	1.26	AB019529	1.00	1.00	1.00	1
38335_at²^{, 3}	U95-A	1	1.00	1.00	0.76	1.00	U88620	1.00	1.00	1.00	1
34146_at²^{, 3}	U95-A	1	1.00	1.00	0.56	1.16	AB019529	1.00	1.00	1.00	1
38334_g_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.80	Y11731	0.80	1.00	0.91	1
38333_at²^{, 3}	U95-A	1	1.00	1.00	0.79	0.83	Y11731	0.80	1.00	0.91	1
205760_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016821	0.60	1.00	0.82	1
205301_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016820	0.60	1.00	0.82	1
205760_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205301_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks OGG1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGGGGAGGG

SOURCE GeneReport for Unigene cluster: Hs.380271
Expression variation in blood from EXPOLDB for OGG1
UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OGG1 gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OGG1¹	--	8-oxoguanine DNA glycosylase	86.97(n) 87.27(a)	484666 XM_541781.2 XP_541781.2
cow (Bos taurus)	OGG1¹	--	8-oxoguanine DNA glycosylase	88.76(n) 88.06(a)	520497 XM_598742.3 XP_598742.2
rat (Rattus norvegicus)	Ogg1¹	--	8-oxoguanine DNA glycosylase	84.66(n) 84.66(a)	81528 NM_030870.1 NP_110497.1
mouse (Mus musculus)	Ogg1^{1, 5}	6 (48.00 cM)⁵	8-oxoguanine DNA-glycosylase 1^{1, 5}	84.5(n)¹ 85.38(a)¹	18294¹ NM_010957.3¹ NP_035087.2¹ AA032890⁵ AA097386⁵ (see all 26)
chicken (Gallus gallus)	OGG1¹	--	8-oxoguanine DNA glycosylase	62.44(n) 58.56(a)	771001 XM_001234322.1 XP_001234323.1

About this table Species with no ortholog for OGG1

ENSEMBL Gene Tree for OGG1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/96 NCBI SNPs in OGG1 are shown (see all 96 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs125701^1,2	A,C,F,H,O	9765478(+)	`AATCCG/ACTGCA`	8	--	ng5¹		16	NS EU EA WA NA	1534
	rs1805373^1,2	C,F,H	9771508(+)	`GCTACG/AAGAGT`	8	Q/R	mis¹ int¹		16	NA NS EU EA WA	2494
	rs1801126^1,2	C,F,H	9766953(+)	`ACGGGG/TCGGTG`	8	--	ut5¹ ese³		6	NS MN EU EA WA	744
--	rs3218996^1,2	A,C,F	9765530(+)	`tggctC/Tacgcc`	8	--	ng5¹		1	NS	178
--	rs17050550^1,2	C,H	9767744(+)	`GCCAGG/TCTAGC`	8	A/S	mis¹ ese³		5	MN EU EA WA	590
	rs3219012^1,2	F,H	9773270(+)	`CCAGGC/TGAAGG`	8	A/V	mis¹ int¹ ese³		5	NS EU EA WA	598
	rs3218997^1,2	C,F	9766344(+)	`TAAGAC/TTGCAA`	5	--	ng5¹ ese³		4	NS NA	292
--	rs3218999^1,2	F	9766691(+)	`CGCCCA/GCAGGC`	8	--	ut5¹ ese³		1	NS	170
--	rs3218998^1,2	F	9766667(+)	`AACCCAGA/-AGAAC`	8	--	ut5¹		1	NS	174
--	rs3218995^1,2	F	9765460(+)	`GGCTGG/AGACAC`	8	--	ng5¹		1	NS	180

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HapMap Linkage Disequilibrium images for OGG1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601982 disorders: 144700

UniProtKB/Swiss-Prot: OGG1_HUMAN, O15527

Defects in OGG1 are associated with tumor formation

Defects in OGG1 are a cause of renal cell carcinoma (RCC1) [MIM:144700]

10/46 Novoseek disease relationships for OGG1 gene (see all 46 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
group b cockayne syndrome	68.62	1	12531019 (1)
cancer lung	60.28	66	18234257 (4), 9681819 (3), 16535829 (3), 18628426 (3) (see all 28)
cancer	54.13	49	17389610 (4), 15584022 (3), 17651912 (2), 9197244 (2) (see all 38)
adenocarcinoma lung	48.88	8	11911490 (1), 17294717 (1), 18338377 (1), 12163326 (1)
xeroderma pigmentosum	45.72	3	12187202 (2), 18349297 (1)
allelic imbalance	42.13	5	12527710 (1), 12378519 (1), 16211227 (1), 11598155 (1)
somatic mutations	42.11	11	11295288 (2), 16211227 (2), 11465542 (2), 11239755 (1) (see all 7)
germ-line mutation	36.98	2	16771692 (1)
polyposis	33.94	1	18515411 (1)
allelic loss	32.04	13	15870915 (8), 11598155 (2)

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Human Gene Mutation Database: OGG1
Genetic Association Database: OGG1
Human Genome Epidemiology Navigator: OGG1 (135 documents)

(Possibly Related Articles in Doctor's Guide)
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New Blood Test Uncovers Individual Risk For Lung Cancer

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/461 PubMed articles for OGG1 gene (see all 461 ):

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. (PubMed id 9207108)^{1, 2, 3, 4} Rosenquist T.A.... Grollman A.P. (1997)
Structure and chromosome location of human OGG1. (PubMed id 10449904)^{2, 3, 4} Ishida T....Aburatani H. (1999)
Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. (PubMed id 9187114)^{1, 3, 4} Aburatani H.... Nishimura S. (1997)
Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations? (PubMed id 15491645)^{1, 3, 6} Aka P....Kirsch-Volders M. (2004)
Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. (PubMed id 9223305)^{1, 3, 4} Radicella J.P.... Boiteux S. (1997)
Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours. (PubMed id 9662341)^{1, 3, 4} Chevillard S.... Boiteux S. (1998)
Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. (PubMed id 17114185)^{1, 3, 4} Radom C.T.... Verdine G.L. (2007)
Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer. (PubMed id 14634453)^{1, 3, 6} Chen L....Park J. (2003)
A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer. (PubMed id 9197244)^{1, 3, 4} Lu R.... Verdine G.L. (1997)
Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients. (PubMed id 15449173)^{1, 3, 6} Kim I.J....Park J.G. (2004)

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Entrez Gene: 4968	HGNC: 8125	AceView: OGG1	Ensembl:ENSG00000114026	euGenes: HUgn4968
ECgene: OGG1	H-InvDB: OGG1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for OGG1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ogg1/

Licensable Technologies for OGG1
(Available from WIS Yeda, Salk, Tufts)

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Licensable Technologies for OGG1 gene:

Weizmann Institute:

Human DNA Repair In Medical Diagnostics

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for OGG1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OGG1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OGG1		Antibodies for OGG1
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	Lentivirus-delivered shRNAs for OGG1		Browse small molecules at Sigma-Aldrich
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Antibodies for OGG1

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OGG1 Gene

protein-coding GIFtS: 74

Aliases &
Descriptions
for OGG1

Summaries
for OGG1

Genomic Location
for OGG1

Proteins
for OGG1

Protein Domains/
Families
for OGG1

Gene Function
for OGG1

Pathways & Interactions
for OGG1

Drugs & Compounds
for OGG1

Transcripts
for OGG1

Expression
for OGG1

Orthologs
for OGG1

Paralogs
for OGG1

SNPs/Variants
for OGG1

Disorders & Mutations
for OGG1

Medical News
for OGG1

Publications
for OGG1

Search for OGG1

Genome Databases showing OGG1

Other Databases showing OGG1

Specialized Databases showing OGG1

Licensable Technologies
for OGG1

Services
for OGG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OGG1 Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor OGG1

Summariesfor OGG1

Genomic Locationfor OGG1

Proteinsfor OGG1

Protein Domains/Familiesfor OGG1

Gene Functionfor OGG1

Pathways & Interactionsfor OGG1

Drugs & Compoundsfor OGG1

Transcriptsfor OGG1

Expression for OGG1

Orthologsfor OGG1

Paralogsfor OGG1

SNPs/Variantsfor OGG1

Disorders & Mutationsfor OGG1

Medical Newsfor OGG1

Publicationsfor OGG1

Search for OGG1

Genome Databases showing OGG1

Other Databases showing OGG1

Specialized Databases showing OGG1

Licensable Technologiesfor OGG1

Servicesfor OGG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OGG1

Summaries
for OGG1

Genomic Location
for OGG1

Proteins
for OGG1

Protein Domains/
Families
for OGG1

Gene Function
for OGG1

Pathways & Interactions
for OGG1

Drugs & Compounds
for OGG1

Transcripts
for OGG1

Expression
for OGG1

Orthologs
for OGG1

Paralogs
for OGG1

SNPs/Variants
for OGG1

Disorders & Mutations
for OGG1

Medical News
for OGG1

Publications
for OGG1

Licensable Technologies
for OGG1

Services
for OGG1