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OGFRL1 Gene

protein-coding GIFtS: 44

GC06P072055

opioid growth factor receptor-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ21079 ^²
MGC102783 ^²
OTTHUMP00000016711 ^²
dJ331H24.1 ^¹, ²

Descriptions
opioid growth factor receptor-like 1 ^²

External Ids
HGNC: 21378¹
Entrez Gene: 79627²
UniProtKB: Q5TC84³
Ensembl: ENSG00000119900⁷

Search outside databases for aliases for OGFRL1 gene

Previous GC identifers: GC00U911650 GC06P071994

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OGFRL1 gene

Entrez Gene cytogenetic band: 6q13 Ensembl cytogenetic band: 6q13 HGNC cytogenetic band: 6q13

OGFRL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P072055: (about GC identifiers)

Start:	72,055,198 bp from pter
End:	72,068,985 bp from pter
Size:	13,788 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007299.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OGRL1_HUMAN, Q5TC84 (See protein sequence)

Recommended Name: Opioid growth factor receptor-like protein 1

Size: 451 amino acids; 51252 Da

Sequence caution: Sequence=AAI11000.1; Type=Frameshift; Positions=339;

Secondary accessions: Q2TAC1 Q8NEQ4 Q9H7B5

REFSEQ proteins: NP_078852.3

ENSEMBL proteins:

ENSP00000359464

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (OGFRL1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--

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Antibodies for OGFRL1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for OGFRL1
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OGFRL1

Assays for OGFRL1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q5TC84

ProtoNet protein and cluster: Q5TC84

UniProtKB/Swiss-Prot: OGRL1_HUMAN, Q5TC84

Similarity: Belongs to the opioid growth factor receptor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OGFRL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OGFRL1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024576

Applied Biosystems Silencer® siRNAs for OGFRL1

Sigma-Aldrich siRNA for OGFRL1

Sigma-Aldrich shRNA for OGFRL1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OGFRL1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024576
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024576
untagged cDNA clones in CMV expression vector (see all 2): NM_024576

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024576

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for OGFRL1 (ENSP00000359464³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FAM135A	ENSP00000354913³	STRING (score=.712)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OGFRL1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OGFRL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OGFRL1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024576

Sigma-Aldrich siRNA for OGFRL1

Sigma-Aldrich shRNA for OGFRL1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024576

REFSEQ mRNAs for OGFRL1 gene:

NM_024576.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024576

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024576
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024576
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_024576

Additional cDNA sequence:

AK024732.1 AK124833.1 AK308623.1 BC018688.1 BC110999.1 CR600219.1 CR603879.1 CR625019.1

6 DOTS entries:

DT.109908 DT.100783695 DT.453902 DT.97801480 DT.121317088 DT.99979926

24/108 AceView cDNA sequences (see all 108 ):

AL598459 BX112732 F07694 BX475129 BQ027256 AI373790 BM667116 BG033944

BM683201 AL598457 AK124833 BM678943 AI741209 CA444408 BP360883 CR600219

BI255978 BP360845 BM719261 BM697954 BM142486 BX110765 CR603879 CR625019

highest scoring ESTs for OGFRL1:

AI339505 AA127532 AA204641 AA774491 AI860226 AK024732 AL577975 AL598457 AL598459 AW103454

Unigene Clusters for OGFRL1:

Opioid growth factor receptor-like 1

Hs.648434 [show with all ESTs], Hs.656091 [show with all ESTs]

Unigene Representative Sequences: AL137346, AK124833

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OGFRL1 (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	·	9c	·	9d	^	10	^	11	^	12a	·	12b
SP1:			-		-		-
SP2:			-		-		-
SP3:							-
SP4:
SP5:					-

About this scheme

ECgene alternative splicing isoforms for OGFRL1

1 Ensembl transcript including schematic representation:

ENST00000370435

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OGFRL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OGFRL1

¹ / ² / ³

9 probe-sets matching OGFRL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
62266_at²^{, 3}	U95-C	1	1.00	1.00	0.80	0.84	AI339505	1.00	1.00	1.00	1
53302_r_at²^{, 3}	U95-B	1	1.00	1.00	0.86	0.78	AI741209	0.20	1.00	0.72	1
79735_at²^{, 3}	U95-D	1	0.94	1.00	0.92	1.21	AA037529	0.20	1.00	0.72	1
66103_at²^{, 3}	U95-C	1	0.62	1.00	0.86	1.01	AW008015	0.20	1.00	0.72	1
83473_at²^{, 3}	U95-E	1	0.38	1.00	0.79	1.19	AI674733	0.20	0.50	0.38	1
219582_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024576	0.60	1.00	0.82	1
238469_at²^{, 3}	U133-B	1	0.91	1.00	--	--	BE620374	0.20	1.00	0.72	1
219582_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
238469_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks OGFRL1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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CGAP SAGE TAG: ATGTTGTACT

SOURCE GeneReport for Unigene clusters: Hs.648434 Hs.656091
UniProtKB/Swiss-Prot: OGRL1_HUMAN, Q5TC84
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OGFRL1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OGFRL1¹	--	opioid growth factor receptor-like 1	90.4(n) 88.53(a)	481876 XM_538997.2 XP_538997.2
chimpanzee (Pan troglodytes)	OGFRL1¹	--	opioid growth factor receptor-like 1	98.89(n) 98.23(a)	472052 XM_527431.2 XP_527431.2
cow (Bos taurus)	OGFRL1¹	--	opioid growth factor receptor-like 1	82.74(n) 82.83(a)	519626 XM_597850.3 XP_597850.3
rat (Rattus norvegicus)	Ogfrl1¹	--	opioid growth factor receptor-like 1	83.52(n) 82.93(a)	316290 NM_001025708.1 NP_001020879.1
mouse (Mus musculus)	Ogfrl1^{1, 5}	1⁵	opioid growth factor receptor-like 1^{1, 5}	84.18(n)¹ 81.37(a)¹	70155¹ NM_001081079.1¹ NP_001074548.1¹ AA051735⁵ AA163610⁵ (see all 19)

About this table Species with no ortholog for OGFRL1

ENSEMBL Gene Tree for OGFRL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for OGFRL1 gene

OGFR²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/76 NCBI SNPs in OGFRL1 are shown (see all 76 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 52)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2208845^1,2	A,C,F,H	72053999(-)	`GGACTA/GAGAAA`	1	--	ng5¹		4		EU EA WA	418
	rs9364153^1,2	C,F,H	72068785(+)	`ATTTGG/ATATAC`	1	--	ng3¹		8		EU EA WA	812
	rs6913383^1,2	A,C	72054752(+)	`ACCATC/GAGCTT`	1	--	ng5¹		0	--	--	--	--
--	rs2224656^1,2	A	72054168(-)	`GGTAGC/TATTAT`	1	--	ng5¹		0	--	--	--	--
--	rs9346459^1,2	A	72068991(+)	`CCTGGA/GCTCAA`	1	--	ng3¹		0	--	--	--	--
--	rs9346460^1,2	A	72069056(+)	`ACGCCC/TGGCTA`	1	--	ng3¹		0	--	--	--	--
--	rs9364151^1,2	A	72053792(+)	`agagcC/Tacagc`	1	--	ng5¹		0	--	--	--	--
	rs2273888^1,2	A,C,F,H	72063233(-)	`TTCAGA/GTGCTG`	1	H/H	syn¹ ese³		8		NA EU EA WA	618
	rs35741445^1,2	F	72059977(-)	`TTTTGA/GTATCG`	1	Y/Y	syn¹		1		NA	74
	rs1885674^1,2	A,C,F,H,O	72056125(-)	`GCCTGA/CGTTGG`	1	--	int¹		5		MN EU EA WA	596

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HapMap Linkage Disequilibrium images for OGFRL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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5 PubMed articles for OGFRL1 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Exclusion of four candidate genes, KHDRBS2, PTP4A1, KIAA1411 and OGFRL1, as causative of autosomal recessive retinitis pigmentosa. (PubMed id 16192744)⁴ Abd El-Aziz M.M.... Bhattacharya S.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)⁴ Mungall A.J.... Beck S. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 79627	HGNC: 21378	AceView: OGFRL1	Ensembl:ENSG00000119900	euGenes: HUgn79627
ECgene: OGFRL1	H-InvDB: OGFRL1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for OGFRL1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for OGFRL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OGFRL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OGFRL1		Antibodies for OGFRL1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OGFRL1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Recombinant & Natural Proteins

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Search Novus for antibodies for OGFRL1

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OGFRL1 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for OGFRL1

Summaries
for OGFRL1

Genomic Location
for OGFRL1

Proteins
for OGFRL1

Protein Domains/
Families
for OGFRL1

Gene Function
for OGFRL1

Pathways & Interactions
for OGFRL1

Drugs & Compounds
for OGFRL1

Transcripts
for OGFRL1

Expression
for OGFRL1

Orthologs
for OGFRL1

Paralogs
for OGFRL1

SNPs/Variants
for OGFRL1

Disorders & Mutations
for OGFRL1

Medical News
for OGFRL1

Publications
for OGFRL1

Search for OGFRL1

Genome Databases showing OGFRL1

Other Databases showing OGFRL1

Specialized Databases showing OGFRL1

Licensable Technologies
for OGFRL1

Services
for OGFRL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OGFRL1 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor OGFRL1

Summariesfor OGFRL1

Genomic Locationfor OGFRL1

Proteinsfor OGFRL1

Protein Domains/Familiesfor OGFRL1

Gene Functionfor OGFRL1

Pathways & Interactionsfor OGFRL1

Drugs & Compoundsfor OGFRL1

Transcriptsfor OGFRL1

Expression for OGFRL1

Orthologsfor OGFRL1

Paralogsfor OGFRL1

SNPs/Variantsfor OGFRL1

Disorders & Mutationsfor OGFRL1

Medical Newsfor OGFRL1

Publicationsfor OGFRL1

Search for OGFRL1

Genome Databases showing OGFRL1

Other Databases showing OGFRL1

Specialized Databases showing OGFRL1

Licensable Technologiesfor OGFRL1

Servicesfor OGFRL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OGFRL1

Summaries
for OGFRL1

Genomic Location
for OGFRL1

Proteins
for OGFRL1

Protein Domains/
Families
for OGFRL1

Gene Function
for OGFRL1

Pathways & Interactions
for OGFRL1

Drugs & Compounds
for OGFRL1

Transcripts
for OGFRL1

Expression
for OGFRL1

Orthologs
for OGFRL1

Paralogs
for OGFRL1

SNPs/Variants
for OGFRL1

Disorders & Mutations
for OGFRL1

Medical News
for OGFRL1

Publications
for OGFRL1

Licensable Technologies
for OGFRL1

Services
for OGFRL1