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Aliases for OGFRL1 Gene

Aliases for OGFRL1 Gene

  • Opioid Growth Factor Receptor-Like 1 2 3
  • Opioid Growth Factor Receptor-Like Protein 1 3
  • DJ331H24.1 3

External Ids for OGFRL1 Gene

Previous GeneCards Identifiers for OGFRL1 Gene

  • GC00U911650
  • GC06P071994
  • GC06P072055
  • GC06P071998
  • GC06P069201

Summaries for OGFRL1 Gene

GeneCards Summary for OGFRL1 Gene

OGFRL1 (Opioid Growth Factor Receptor-Like 1) is a Protein Coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is OGFR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFRL1 Gene

Genomics for OGFRL1 Gene

Regulatory Elements for OGFRL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OGFRL1 Gene

Start:
71,288,774 bp from pter
End:
71,308,950 bp from pter
Size:
20,177 bases
Orientation:
Plus strand

Genomic View for OGFRL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OGFRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFRL1 Gene

Proteins for OGFRL1 Gene

  • Protein details for OGFRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TC84-OGRL1_HUMAN
    Recommended name:
    Opioid growth factor receptor-like protein 1
    Protein Accession:
    Q5TC84
    Secondary Accessions:
    • Q2TAC1
    • Q8NEQ4
    • Q9H7B5

    Protein attributes for OGFRL1 Gene

    Size:
    451 amino acids
    Molecular mass:
    51252 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI11000.1; Type=Frameshift; Positions=339; Evidence={ECO:0000305};

neXtProt entry for OGFRL1 Gene

Proteomics data for OGFRL1 Gene at MOPED

Post-translational modifications for OGFRL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OGFRL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OGFRL1 Gene

Domains for OGFRL1 Gene

Protein Domains for OGFRL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OGFRL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TC84

UniProtKB/Swiss-Prot:

OGRL1_HUMAN :
  • Q5TC84
Family:
  • Belongs to the opioid growth factor receptor family.
genes like me logo Genes that share domains with OGFRL1: view

No data available for Gene Families for OGFRL1 Gene

Function for OGFRL1 Gene

Gene Ontology (GO) - Molecular Function for OGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
genes like me logo Genes that share ontologies with OGFRL1: view

Phenotypes for OGFRL1 Gene

GenomeRNAi human phenotypes for OGFRL1:
genes like me logo Genes that share phenotypes with OGFRL1: view

Animal Model Products

CRISPR Products

miRNA for OGFRL1 Gene

miRTarBase miRNAs that target OGFRL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OGFRL1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OGFRL1 Gene

Localization for OGFRL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OGFRL1 Gene COMPARTMENTS Subcellular localization image for OGFRL1 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OGFRL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OGFRL1 Gene

Pathways for OGFRL1 Gene

SuperPathways for OGFRL1 Gene

No Data Available

Interacting Proteins for OGFRL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359464%0d%0a9606.ENSP00000372191%0d%0a
Selected Interacting proteins: ENSP00000359464 for OGFRL1 Gene via STRING

Symbol External ID(s) Details
SIRT3

Gene Ontology (GO) - Biological Process for OGFRL1 Gene

None

No data available for Pathways by source for OGFRL1 Gene

Transcripts for OGFRL1 Gene

Unigene Clusters for OGFRL1 Gene

Opioid growth factor receptor-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OGFRL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGFRL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5: -
SP6: - -

Relevant External Links for OGFRL1 Gene

GeneLoc Exon Structure for
OGFRL1
ECgene alternative splicing isoforms for
OGFRL1

Expression for OGFRL1 Gene

mRNA expression in normal human tissues for OGFRL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for OGFRL1 Gene

SOURCE GeneReport for Unigene cluster for OGFRL1 Gene Hs.648434

mRNA Expression by UniProt/SwissProt for OGFRL1 Gene

Q5TC84-OGRL1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with OGFRL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for OGFRL1 Gene

Orthologs for OGFRL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGFRL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGFRL1 35
  • 98.89 (n)
  • 98.23 (a)
OGFRL1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OGFRL1 35
  • 82.52 (n)
  • 82.7 (a)
OGFRL1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OGFRL1 35
  • 90.4 (n)
  • 88.53 (a)
OGFRL1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ogfrl1 35
  • 84.33 (n)
  • 81.37 (a)
Ogfrl1 16
Ogfrl1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OGFRL1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGFRL1 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ogfrl1 35
  • 83.52 (n)
  • 82.93 (a)
chicken
(Gallus gallus)
Aves OGFRL1 35
  • 73.04 (n)
  • 71.83 (a)
OGFRL1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGFRL1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ogfrl1 35
  • 68.29 (n)
  • 68 (a)
zebrafish
(Danio rerio)
Actinopterygii ogfrl1 35
  • 65.89 (n)
  • 67.77 (a)
ogfrl1 36
  • 54 (a)
OneToOne
Species with no ortholog for OGFRL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFRL1 Gene

ENSEMBL:
Gene Tree for OGFRL1 (if available)
TreeFam:
Gene Tree for OGFRL1 (if available)

Paralogs for OGFRL1 Gene

Paralogs for OGFRL1 Gene

Selected SIMAP similar genes for OGFRL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OGFRL1: view

Variants for OGFRL1 Gene

Sequence variations from dbSNP and Humsavar for OGFRL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1825 -- 71,308,989(-) AATCA(A/C/T)AAAAA downstream-variant-500B
rs1044759 -- 71,307,461(+) CTTAA(A/C/T)GATCT utr-variant-3-prime
rs1044760 -- 71,307,462(+) TTAAC(G/T)ATCTT utr-variant-3-prime
rs1044762 -- 71,308,150(+) GTGTG(C/T)AGCAA utr-variant-3-prime
rs1056849 -- 71,302,949(+) ACCTC(C/T)TTGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OGFRL1 Gene

Variant ID Type Subtype PubMed ID
esv25459 CNV Loss 19812545

Relevant External Links for OGFRL1 Gene

HapMap Linkage Disequilibrium report
OGFRL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFRL1 Gene

Disorders for OGFRL1 Gene

Relevant External Links for OGFRL1

Genetic Association Database (GAD)
OGFRL1
genes like me logo Genes that share disorders with OGFRL1: view

No data available for UniProtKB/Swiss-Prot for OGFRL1 Gene

Publications for OGFRL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 48
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Exclusion of four candidate genes, KHDRBS2, PTP4A1, KIAA1411 and OGFRL1, as causative of autosomal recessive retinitis pigmentosa. (PMID: 16192744) Abd El-Aziz M.M. … Bhattacharya S.S. (Ophthalmic Res. 2006) 4

Products for OGFRL1 Gene

Sources for OGFRL1 Gene

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