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Aliases for OGFRL1 Gene

Aliases for OGFRL1 Gene

  • Opioid Growth Factor Receptor-Like 1 2 3
  • DJ331H24.1 3

External Ids for OGFRL1 Gene

Previous GeneCards Identifiers for OGFRL1 Gene

  • GC00U911650
  • GC06P071994
  • GC06P072055
  • GC06P071998
  • GC06P069201

Summaries for OGFRL1 Gene

GeneCards Summary for OGFRL1 Gene

OGFRL1 (Opioid Growth Factor Receptor-Like 1) is a Protein Coding gene. Diseases associated with OGFRL1 include retinitis pigmentosa. GO annotations related to this gene include receptor activity. An important paralog of this gene is OGFR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFRL1 Gene

Genomics for OGFRL1 Gene

Regulatory Elements for OGFRL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OGFRL1 Gene

71,288,774 bp from pter
71,308,953 bp from pter
20,180 bases
Plus strand

Genomic View for OGFRL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for OGFRL1 Gene

Proteins for OGFRL1 Gene

  • Protein details for OGFRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Opioid growth factor receptor-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q2TAC1
    • Q8NEQ4
    • Q9H7B5

    Protein attributes for OGFRL1 Gene

    451 amino acids
    Molecular mass:
    51252 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI11000.1; Type=Frameshift; Positions=339; Evidence={ECO:0000305};

neXtProt entry for OGFRL1 Gene

Proteomics data for OGFRL1 Gene at MOPED

Post-translational modifications for OGFRL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OGFRL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OGFRL1 Gene

Domains & Families for OGFRL1 Gene

Protein Domains for OGFRL1 Gene


Suggested Antigen Peptide Sequences for OGFRL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the opioid growth factor receptor family.
  • Belongs to the opioid growth factor receptor family.
genes like me logo Genes that share domains with OGFRL1: view

No data available for Gene Families for OGFRL1 Gene

Function for OGFRL1 Gene

Gene Ontology (GO) - Molecular Function for OGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
genes like me logo Genes that share ontologies with OGFRL1: view

Phenotypes for OGFRL1 Gene

GenomeRNAi human phenotypes for OGFRL1:
genes like me logo Genes that share phenotypes with OGFRL1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OGFRL1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for OGFRL1 Gene

Localization for OGFRL1 Gene

Subcellular locations from

Jensen Localization Image for OGFRL1 Gene COMPARTMENTS Subcellular localization image for OGFRL1 gene
Compartment Confidence
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for OGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OGFRL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OGFRL1 Gene

Pathways & Interactions for OGFRL1 Gene

SuperPathways for OGFRL1 Gene

No Data Available

Interacting Proteins for OGFRL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359464 for OGFRL1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for OGFRL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for OGFRL1 Gene

Drugs & Compounds for OGFRL1 Gene

No Compound Related Data Available

Transcripts for OGFRL1 Gene

Unigene Clusters for OGFRL1 Gene

Opioid growth factor receptor-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OGFRL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGFRL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - - -
SP3: -
SP5: -
SP6: - -

Relevant External Links for OGFRL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OGFRL1 Gene

mRNA expression in normal human tissues for OGFRL1 Gene

Protein differential expression in normal tissues from HIPED for OGFRL1 Gene

This gene is overexpressed in Frontal cortex (22.7), Spinal cord (11.5), Monocytes (11.0), and Peripheral blood mononuclear cells (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for OGFRL1 Gene

SOURCE GeneReport for Unigene cluster for OGFRL1 Gene Hs.648434

mRNA Expression by UniProt/SwissProt for OGFRL1 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with OGFRL1: view

Protein tissue co-expression partners for OGFRL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for OGFRL1 Gene

Orthologs for OGFRL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGFRL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OGFRL1 35
  • 82.52 (n)
  • 82.7 (a)
  • 80 (a)
(Canis familiaris)
Mammalia OGFRL1 35
  • 90.4 (n)
  • 88.53 (a)
  • 87 (a)
(Mus musculus)
Mammalia Ogfrl1 35
  • 84.33 (n)
  • 81.37 (a)
Ogfrl1 16
Ogfrl1 36
  • 79 (a)
(Pan troglodytes)
Mammalia OGFRL1 35
  • 98.89 (n)
  • 98.23 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Ogfrl1 35
  • 83.52 (n)
  • 82.93 (a)
(Monodelphis domestica)
Mammalia OGFRL1 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia OGFRL1 36
  • 57 (a)
(Gallus gallus)
Aves OGFRL1 35
  • 73.04 (n)
  • 71.83 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia OGFRL1 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ogfrl1 35
  • 68.29 (n)
  • 68 (a)
(Danio rerio)
Actinopterygii ogfrl1 35
  • 65.89 (n)
  • 67.77 (a)
ogfrl1 36
  • 54 (a)
Species with no ortholog for OGFRL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFRL1 Gene

Gene Tree for OGFRL1 (if available)
Gene Tree for OGFRL1 (if available)

Paralogs for OGFRL1 Gene

Paralogs for OGFRL1 Gene

(1) SIMAP similar genes for OGFRL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OGFRL1: view

Variants for OGFRL1 Gene

Sequence variations from dbSNP and Humsavar for OGFRL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_037842 -

Structural Variations from Database of Genomic Variants (DGV) for OGFRL1 Gene

Variant ID Type Subtype PubMed ID
esv25459 CNV Loss 19812545

Variation tolerance for OGFRL1 Gene

Residual Variation Intolerance Score: 26.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.65; 86.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OGFRL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFRL1 Gene

Disorders for OGFRL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OGFRL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association

Relevant External Links for OGFRL1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OGFRL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OGFRL1 Gene

Publications for OGFRL1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 67
  3. Exclusion of four candidate genes, KHDRBS2, PTP4A1, KIAA1411 and OGFRL1, as causative of autosomal recessive retinitis pigmentosa. (PMID: 16192744) Abd El-Aziz M.M. … Bhattacharya S.S. (Ophthalmic Res. 2006) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for OGFRL1 Gene

Sources for OGFRL1 Gene

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