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Aliases for OGFRL1 Gene

Aliases for OGFRL1 Gene

  • Opioid Growth Factor Receptor Like 1 2 3 5
  • Opioid Growth Factor Receptor-Like Protein 1 3
  • DJ331H24.1 3

External Ids for OGFRL1 Gene

Previous GeneCards Identifiers for OGFRL1 Gene

  • GC00U911650
  • GC06P071994
  • GC06P072055
  • GC06P071998
  • GC06P069201

Summaries for OGFRL1 Gene

GeneCards Summary for OGFRL1 Gene

OGFRL1 (Opioid Growth Factor Receptor Like 1) is a Protein Coding gene. Diseases associated with OGFRL1 include Retinitis Pigmentosa. GO annotations related to this gene include receptor activity. An important paralog of this gene is OGFR.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFRL1 Gene

Genomics for OGFRL1 Gene

Regulatory Elements for OGFRL1 Gene

Enhancers for OGFRL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G071247 1.2 FANTOM5 Ensembl ENCODE 22.7 -39.0 -38955 4.0 SRF PKNOX1 JUN NR2F1 CEBPB ZNF384 EP300 GABPA GATA2 SCRT2 OGFRL1 ENSG00000230597 ENSG00000232295 LOC100132834 GC06M071204
GH06G071333 1.2 FANTOM5 Ensembl ENCODE 17.1 +45.2 45200 1.4 JUN BHLHE40 CEBPB EP300 NR2F2 JUND FOS MAFK NFE2L2 OGFRL1 RIMS1 ENSG00000230597 GC06P071361
GH06G071418 1.2 ENCODE dbSUPER 9.5 +131.1 131134 3.5 TBP PKNOX1 SREBF2 ZSCAN4 KLF17 SIN3A GLI4 RAD21 RFX5 YY1 LINC00472 OGFRL1 RIMS1 ENSG00000232295 ENSG00000269966
GH06G071347 0.6 FANTOM5 16.8 +58.5 58478 0.4 NFYB DPF2 SPI1 OGFRL1 GC06P071361 ENSG00000230597
GH06G071476 1 Ensembl ENCODE 9.5 +190.3 190307 4.6 TBP JUN RFX5 ZNF664 GATA2 RCOR1 FOS BHLHE40 CEBPB USF2 MIR30A OGFRL1 LOC105377853 GC06P071540
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OGFRL1 on UCSC Golden Path with GeneCards custom track

Promoters for OGFRL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000198705 526 2601 PKNOX1 SIN3A FEZF1 ZNF2 GLIS2 GATA2 ZNF207 KLF7 FOS ZNF263

Genomic Location for OGFRL1 Gene

Chromosome:
6
Start:
71,288,774 bp from pter
End:
71,308,953 bp from pter
Size:
20,180 bases
Orientation:
Plus strand

Genomic View for OGFRL1 Gene

Genes around OGFRL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGFRL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGFRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFRL1 Gene

Proteins for OGFRL1 Gene

  • Protein details for OGFRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TC84-OGRL1_HUMAN
    Recommended name:
    Opioid growth factor receptor-like protein 1
    Protein Accession:
    Q5TC84
    Secondary Accessions:
    • Q2TAC1
    • Q8NEQ4
    • Q9H7B5

    Protein attributes for OGFRL1 Gene

    Size:
    451 amino acids
    Molecular mass:
    51252 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI11000.1; Type=Frameshift; Positions=339; Evidence={ECO:0000305};

neXtProt entry for OGFRL1 Gene

Post-translational modifications for OGFRL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OGFRL1 Gene

No data available for DME Specific Peptides for OGFRL1 Gene

Domains & Families for OGFRL1 Gene

Protein Domains for OGFRL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OGFRL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TC84

UniProtKB/Swiss-Prot:

OGRL1_HUMAN :
  • Belongs to the opioid growth factor receptor family.
Family:
  • Belongs to the opioid growth factor receptor family.
genes like me logo Genes that share domains with OGFRL1: view

No data available for Gene Families for OGFRL1 Gene

Function for OGFRL1 Gene

Gene Ontology (GO) - Molecular Function for OGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
genes like me logo Genes that share ontologies with OGFRL1: view
genes like me logo Genes that share phenotypes with OGFRL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGFRL1 Gene

Localization for OGFRL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGFRL1 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OGFRL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OGFRL1 Gene

Pathways & Interactions for OGFRL1 Gene

SuperPathways for OGFRL1 Gene

No Data Available

Interacting Proteins for OGFRL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359464%0d%0a9606.ENSP00000257904%0d%0a
Selected Interacting proteins: Q5TC84-OGRL1_HUMAN ENSP00000359464 for OGFRL1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for OGFRL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OGFRL1 Gene

Drugs & Compounds for OGFRL1 Gene

No Compound Related Data Available

Transcripts for OGFRL1 Gene

Unigene Clusters for OGFRL1 Gene

Opioid growth factor receptor-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGFRL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5: -
SP6: - -

Relevant External Links for OGFRL1 Gene

GeneLoc Exon Structure for
OGFRL1
ECgene alternative splicing isoforms for
OGFRL1

Expression for OGFRL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OGFRL1 Gene

Protein differential expression in normal tissues from HIPED for OGFRL1 Gene

This gene is overexpressed in Frontal cortex (22.7), Spinal cord (11.5), Monocytes (11.0), and Peripheral blood mononuclear cells (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OGFRL1 Gene



Protein tissue co-expression partners for OGFRL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OGFRL1 Gene:

OGFRL1

SOURCE GeneReport for Unigene cluster for OGFRL1 Gene:

Hs.648434

mRNA Expression by UniProt/SwissProt for OGFRL1 Gene:

Q5TC84-OGRL1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for OGFRL1 Gene

  • Lung(4.4)
  • Nervous system(4.3)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with OGFRL1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OGFRL1 Gene

Orthologs for OGFRL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGFRL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGFRL1 34 35
  • 98.89 (n)
dog
(Canis familiaris)
Mammalia OGFRL1 34 35
  • 90.4 (n)
mouse
(Mus musculus)
Mammalia Ogfrl1 34 16 35
  • 84.33 (n)
rat
(Rattus norvegicus)
Mammalia Ogfrl1 34
  • 83.52 (n)
cow
(Bos Taurus)
Mammalia OGFRL1 34 35
  • 82.52 (n)
oppossum
(Monodelphis domestica)
Mammalia OGFRL1 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGFRL1 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves OGFRL1 34 35
  • 73.04 (n)
lizard
(Anolis carolinensis)
Reptilia OGFRL1 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ogfrl1 34
  • 68.29 (n)
zebrafish
(Danio rerio)
Actinopterygii ogfrl1 34 35
  • 65.89 (n)
Species where no ortholog for OGFRL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFRL1 Gene

ENSEMBL:
Gene Tree for OGFRL1 (if available)
TreeFam:
Gene Tree for OGFRL1 (if available)

Paralogs for OGFRL1 Gene

Paralogs for OGFRL1 Gene

(1) SIMAP similar genes for OGFRL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OGFRL1: view

Variants for OGFRL1 Gene

Sequence variations from dbSNP and Humsavar for OGFRL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000014324 -- 71,300,076(+) TGCTA(A/G)TTATT intron-variant
rs1000074607 -- 71,290,265(+) AAACC(C/G)AAGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000136343 -- 71,309,403(+) AGAAT(A/G)AGTTG downstream-variant-500B
rs1000378741 -- 71,286,354(+) AGGCC(A/T)CAGCT upstream-variant-2KB
rs1000385780 -- 71,302,210(+) GACAA(C/T)GAATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OGFRL1 Gene

Variant ID Type Subtype PubMed ID
esv25459 CNV loss 19812545
esv3609459 CNV gain 21293372
nsv1073568 CNV deletion 25765185

Variation tolerance for OGFRL1 Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.65; 86.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OGFRL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OGFRL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFRL1 Gene

Disorders for OGFRL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OGFRL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for OGFRL1

Genetic Association Database (GAD)
OGFRL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OGFRL1
genes like me logo Genes that share disorders with OGFRL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OGFRL1 Gene

Publications for OGFRL1 Gene

  1. Exclusion of four candidate genes, KHDRBS2, PTP4A1, KIAA1411 and OGFRL1, as causative of autosomal recessive retinitis pigmentosa. (PMID: 16192744) Abd El-Aziz M.M. … Bhattacharya S.S. (Ophthalmic Res. 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 46 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for OGFRL1 Gene

Sources for OGFRL1 Gene

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