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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OGFRL1 Gene

protein-coding GIFtS: 45
GCID: GC06P071998

opioid growth factor receptor-like 1

Explore 2 diseases affiliated with
OGFRL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Opioid Growth Factor Receptor-Like 1¹ ²
DJ331H24.1¹
Opioid Growth Factor Receptor-Like Protein 1²

External Ids:	HGNC: 21378¹	Entrez Gene: 79627²	Ensembl: ENSG00000119900⁷	UniProtKB: Q5TC84³

Export aliases for OGFRL1 gene to outside databases

Previous GC identifers: GC00U911650 GC06P071994 GC06P072055 GC06P069201

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OGFRL1 gene promoter:
C/EBPbeta AML1a Egr-1 STAT5A Egr-4 C/EBPalpha AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OGFRL1 promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OGFRL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13 Ensembl cytogenetic band: 6q13 HGNC cytogenetic band: 6q13

OGFRL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OGFRL1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P071998: view genomic region (about GC identifiers)

Start:	71,998,477 bp from pter	End:	72,011,973 bp from pter
Size:	13,497 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OGRL1_HUMAN, Q5TC84 (See protein sequence)

Recommended Name: Opioid growth factor receptor-like protein 1

Size: 451 amino acids; 51252 Da

Sequence caution: Sequence=AAI11000.1; Type=Frameshift; Positions=339;

Secondary accessions: Q2TAC1 Q8NEQ4 Q9H7B5

Explore the universe of human proteins at neXtProt for OGFRL1: NX_Q5TC84

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5TC84

OGFRL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_078852.3

ENSEMBL proteins:

ENSP00000359464

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	Uscn Proteins for OGFRL1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--

OGFRL1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OGFRL1 for domains About GeneDecksing

1 InterPro domain/family:

IPR006757 OGF_rcpt

Graphical View of Domain Structure for InterPro Entry Q5TC84

ProtoNet protein and cluster: Q5TC84

UniProtKB/Swiss-Prot: OGRL1_HUMAN, Q5TC84

Similarity: Belongs to the opioid growth factor receptor family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--

OGFRL1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for OGFRL1:

Decreased Salmonella enterica

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OGFRL1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for OGFRL1 (ENSP00000359464⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SIRT3	ENSP00000372191⁴	STRING: ENSP00000372191

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OGFRL1
Search CenterWatch for drugs/clinical trials and news about OGFRL1 / OGRL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for OGFRL1 gene:

NM_024576.3

Unigene Clusters for OGFRL1:

Opioid growth factor receptor-like 1

Hs.648434 [show with all ESTs], Hs.656091 [show with all ESTs]

Unigene Representative Sequences: AL137346, AK124833

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370435(uc003pfx.1) ENST00000467503

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Additional cDNA sequence:

AK024732.1 AK124833.1 AK308623.1 BC018688.1 BC110999.1

6 DOTS entries:

DT.109908 DT.100783695 DT.453902 DT.97801480 DT.121317088 DT.99979926

24/108 AceView cDNA sequences (see all 108):

BG033944 F07694 AK124833 BX379107 BQ027256 BX110765 BI255978 BM719261

BM263209 BM667116 BX112732 AL598459 BM678943 AI373790 BP360883 CR625019

CR603879 CR600219 BM683201 BM697954 BP360845 AI741209 AL598457 CA444408

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OGFRL1 (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	·	9c	·	9d	^	10	^	11	^	12a	·	12b
SP1:			-		-		-
SP2:			-		-		-
SP3:							-
SP4:
SP5:					-

ECgene alternative splicing isoforms for OGFRL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OGFRL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTTGTACT

About this image

OGFRL1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See OGFRL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OGFRL1

SOURCE GeneReport for Unigene clusters: Hs.648434 Hs.656091

UniProtKB/Swiss-Prot: OGRL1_HUMAN, Q5TC84

Tissue specificity: Ubiquitous

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OGFRL1 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	OGFRL1¹	opioid growth factor receptor-like 1	73.94(n) 73.2(a)		421869 XM_419886.3 XP_419886.3
lizard (Anolis carolinensis)	Reptilia	OGFRL1⁶	--	65(a)	1 ↔ 1	1(168050100-168072443)
zebrafish (Danio rerio)	Actinopterygii	LOC559942¹	opioid growth factor receptor-like	65.16(n) 67.64(a)		559942 XM_683337.4 XP_688429.4

ENSEMBL Gene Tree for OGFRL1 (if available)
TreeFam Gene Tree for OGFRL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OGFRL1 gene

OGFR²

1 SIMAP similar gene for OGFRL1 using alignment to 1 protein entry: OGRL1_HUMAN:

OGFR

OGFRL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184141400^1,2		--	71996480(+)	`GTTCCA/GGTCTT`	1	--	us2k¹		0	--	--	--	--
rs112824477^1,2	C,F,	--	71996516(+)	`GCTTTG/AAGCAG`	1	--	us2k¹		4		NA CSA WA	242
rs188593576^1,2		--	71996518(+)	`TTTGAA/GCAGTT`	1	--	us2k¹		0	--	--	--	--
rs143598642^1,2	C,	--	71996585(+)	`AAGTA-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs180688925^1,2		--	71996601(+)	`GCGGGA/GGGTGG`	1	--	us2k¹		0	--	--	--	--
rs186181180^1,2		--	71996656(+)	`CCTGAG/TCTCAG`	1	--	us2k¹		0	--	--	--	--
rs190252829^1,2		--	71996685(+)	`TCCCGA/CGTTCA`	1	--	us2k¹		0	--	--	--	--
rs12055385^1,2	C,F,	--	71996789(+)	`GTTTCG/ATCATG`	1	--	us2k¹		3		WA CSA NA	124
rs182540375^1,2		--	71996855(+)	`CCAAAG/TTTCTG`	1	--	us2k¹		0	--	--	--	--
rs148791780^1,2		--	71996871(+)	`ACAGGC/TGTGAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for OGFRL1 (71998477 - 72011973 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OGFRL1
1 Indel: 69555

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OGFRL1 for disorders About GeneDecksing

2 diseases for OGFRL1: About MalaCards

retinitis pigmentosa retinitis

Export disorders for OGFRL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OGFRL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OGFRL1)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Exclusion of four candidate genes, KHDRBS2, PTP4A1, KIAA1411 and OGFRL1, as causative of autosomal recessive retinitis pigmentosa. (PubMed id 16192744)² Abd El-Aziz M.M.... Bhattacharya S.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)² Mungall A.J.... Beck S. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79627	HGNC: 21378	AceView: OGFRL1	Ensembl:ENSG00000119900	euGenes: HUgn79627
ECgene: OGFRL1	H-InvDB: OGFRL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OGFRL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for OGFRL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OGFRL1 gene:
Search GeneIP for patents involving OGFRL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGFRL1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes OGFRL1 gene at Home site.

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OGFRL1 Gene

opioid growth factor receptor-like 1

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Export list of displayed genes

OGFRL1 Gene

opioid growth factor receptor-like 1

Aliasesfor OGFRL1 gene

Summariesfor OGFRL1 gene

Genomic Viewsfor OGFRL1 gene

Proteinsfor OGFRL1 gene

Protein Domains /Familiesfor OGFRL1 gene

Functionfor OGFRL1 gene

Pathways & Interactionsfor OGFRL1 gene

Drugs & Compoundsfor OGFRL1 gene

Transcriptsfor OGFRL1 gene

Expression for OGFRL1 gene

Orthologsfor OGFRL1 gene

Paralogsfor OGFRL1 gene

Genomic Variantsfor OGFRL1 gene

Disorders / Diseasesfor OGFRL1 gene

Publicationsfor OGFRL1 gene

External Searches for OGFRL1 gene

Genome Databases showing OGFRL1 gene

Other Databases showing OGFRL1 gene

Specialized Databases showing OGFRL1 gene

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Aliases
for OGFRL1 gene

Summaries
for OGFRL1 gene

Genomic Views
for OGFRL1 gene

Proteins
for OGFRL1 gene

Protein Domains /
Families
for OGFRL1 gene

Function
for OGFRL1 gene

Pathways & Interactions
for OGFRL1 gene

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for OGFRL1 gene

Transcripts
for OGFRL1 gene

Expression
for OGFRL1 gene

Orthologs
for OGFRL1 gene

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for OGFRL1 gene

Genomic Variants
for OGFRL1 gene

Disorders / Diseases
for OGFRL1 gene

Publications
for OGFRL1 gene

Intellectual Property
for OGFRL1 gene

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for OGFRL1 gene