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Aliases for OGFR Gene

Aliases for OGFR Gene

  • Opioid Growth Factor Receptor 2 3 5
  • Zeta-Type Opioid Receptor 4
  • Protein 7-60 4
  • OGFr 4

External Ids for OGFR Gene

Previous GeneCards Identifiers for OGFR Gene

  • GC20P061313
  • GC20P062115
  • GC20P062162
  • GC20P060906
  • GC20P061436
  • GC20P058154

Summaries for OGFR Gene

Entrez Gene Summary for OGFR Gene

  • The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for OGFR Gene

OGFR (Opioid Growth Factor Receptor) is a Protein Coding gene. Among its related pathways are Phospholipase-C Pathway and CREB Pathway. GO annotations related to this gene include receptor activity and opioid receptor activity. An important paralog of this gene is OGFRL1.

UniProtKB/Swiss-Prot for OGFR Gene

  • Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.

Gene Wiki entry for OGFR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFR Gene

Genomics for OGFR Gene

Regulatory Elements for OGFR Gene

Enhancers for OGFR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G062793 1.8 FANTOM5 ENCODE dbSUPER 23.9 -9.0 -9000 5.0 HDGF MLX ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZBTB7B OGFR LAMA5 MRGBP RTEL1 DIDO1 DPH3P1 LOC105372716
GH20G062649 1.8 FANTOM5 ENCODE dbSUPER 21 -152.7 -152734 4.7 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B OGFR OGFR-AS1 MIR1-1 MIR1-1HG C20orf166-AS1 DIDO1 OSBPL2 DPH3P1 BHLHE23 ENSG00000277496
GH20G062738 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.1 -64.1 -64142 4.9 PKNOX1 ATF1 SIN3A ZNF766 GLIS2 GATA2 ELK1 FOS JUNB MIER2 OGFR NTSR1 LINC00659 LINC00686 OGFR-AS1 MIR1-1 C20orf166-AS1 MIR1-1HG ENSG00000229882 ENSG00000232121
GH20G062791 1.3 Ensembl ENCODE 20.7 -12.7 -12702 1.8 HDGF PKNOX1 MLX ARID4B SIN3A YBX1 ZNF2 ZBTB7B SLC30A9 ZNF207 OGFR TNFRSF6B LOC105372716 LINC00659
GH20G062803 1.1 ENCODE 21.4 +0.7 744 3.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B OGFR RTEL1 TNFRSF6B MRGBP OGFR-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OGFR on UCSC Golden Path with GeneCards custom track

Promoters for OGFR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139799 375 1601 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B YY1

Genomic Location for OGFR Gene

Chromosome:
20
Start:
62,804,825 bp from pter
End:
62,814,000 bp from pter
Size:
9,176 bases
Orientation:
Plus strand

Genomic View for OGFR Gene

Genes around OGFR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGFR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFR Gene

Proteins for OGFR Gene

  • Protein details for OGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZT2-OGFR_HUMAN
    Recommended name:
    Opioid growth factor receptor
    Protein Accession:
    Q9NZT2
    Secondary Accessions:
    • O96029
    • Q4VXW5
    • Q96CM2
    • Q9BQW1
    • Q9H4H0
    • Q9H7J5
    • Q9NZT3
    • Q9NZT4

    Protein attributes for OGFR Gene

    Size:
    677 amino acids
    Molecular mass:
    73325 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD03737.1; Type=Frameshift; Positions=1, 181; Evidence={ECO:0000305}; Sequence=AAD03745.1; Type=Frameshift; Positions=1, 181; Evidence={ECO:0000305}; Sequence=CAC28882.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for OGFR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGFR Gene

Post-translational modifications for OGFR Gene

  • Ubiquitination at posLast=158158, posLast=218218, and Lys291
  • Modification sites at PhosphoSitePlus

Other Protein References for OGFR Gene

No data available for DME Specific Peptides for OGFR Gene

Domains & Families for OGFR Gene

Protein Domains for OGFR Gene

Suggested Antigen Peptide Sequences for OGFR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZT2

UniProtKB/Swiss-Prot:

OGFR_HUMAN :
  • Belongs to the opioid growth factor receptor family.
Family:
  • Belongs to the opioid growth factor receptor family.
genes like me logo Genes that share domains with OGFR: view

No data available for Gene Families for OGFR Gene

Function for OGFR Gene

Molecular function for OGFR Gene

UniProtKB/Swiss-Prot Function:
Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.

Gene Ontology (GO) - Molecular Function for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0004985 opioid receptor activity NAS 10677613
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with OGFR: view
genes like me logo Genes that share phenotypes with OGFR: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OGFR

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OGFR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGFR Gene

Localization for OGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGFR Gene

Cytoplasm. Nucleus. Note=The OGF/OGFR complex is probably translocated to the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGFR gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OGFR: view

Pathways & Interactions for OGFR Gene

genes like me logo Genes that share pathways with OGFR: view

Gene Ontology (GO) - Biological Process for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 10677613
GO:0038003 opioid receptor signaling pathway IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with OGFR: view

No data available for SIGNOR curated interactions for OGFR Gene

Drugs & Compounds for OGFR Gene

(1) Drugs for OGFR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with OGFR: view

Transcripts for OGFR Gene

Unigene Clusters for OGFR Gene

Opioid growth factor receptor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OGFR

Alternative Splicing Database (ASD) splice patterns (SP) for OGFR Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - - -
SP3: -
SP4:
SP5: - -
SP6: -

Relevant External Links for OGFR Gene

GeneLoc Exon Structure for
OGFR
ECgene alternative splicing isoforms for
OGFR

Expression for OGFR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OGFR Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for OGFR Gene

This gene is overexpressed in Lymph node (12.6), Peripheral blood mononuclear cells (11.2), Blymphocyte (8.1), and Monocytes (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OGFR Gene



Protein tissue co-expression partners for OGFR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OGFR Gene:

OGFR

SOURCE GeneReport for Unigene cluster for OGFR Gene:

Hs.67896

mRNA Expression by UniProt/SwissProt for OGFR Gene:

Q9NZT2-OGFR_HUMAN
Tissue specificity: Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.

Evidence on tissue expression from TISSUES for OGFR Gene

  • Skin(4.6)
  • Liver(4.3)
  • Spleen(4.3)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with OGFR: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OGFR Gene

Orthologs for OGFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGFR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGFR 34 35
  • 97.08 (n)
dog
(Canis familiaris)
Mammalia OGFR 34 35
  • 85.89 (n)
cow
(Bos Taurus)
Mammalia OGFR 34 35
  • 77.73 (n)
mouse
(Mus musculus)
Mammalia Ogfr 34 16 35
  • 71.27 (n)
rat
(Rattus norvegicus)
Mammalia Ogfr 34
  • 71.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OGFR 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves OGFR 34 35
  • 51.18 (n)
lizard
(Anolis carolinensis)
Reptilia OGFR 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17622 34
zebrafish
(Danio rerio)
Actinopterygii OGFR (3 of 4) 35
  • 39 (a)
OneToMany
ogfr 35
  • 33 (a)
OneToMany
ogfrl2 35
  • 31 (a)
OneToMany
OGFR (4 of 4) 35
  • 28 (a)
OneToMany
Species where no ortholog for OGFR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFR Gene

ENSEMBL:
Gene Tree for OGFR (if available)
TreeFam:
Gene Tree for OGFR (if available)

Paralogs for OGFR Gene

Paralogs for OGFR Gene

(1) SIMAP similar genes for OGFR Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for OGFR Gene

genes like me logo Genes that share paralogs with OGFR: view

Variants for OGFR Gene

Sequence variations from dbSNP and Humsavar for OGFR Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000234821 -- 62,807,370(+) GGGAA(C/T)CCCCA intron-variant, upstream-variant-2KB
rs1000334423 -- 62,812,138(+) ACCTC(A/G)TGGAG intron-variant
rs1000523811 -- 62,806,246(+) GTTGA(A/C/G)AAATC intron-variant, upstream-variant-2KB
rs1000677977 -- 62,811,081(+) TCCAG(A/G)CTAGG intron-variant
rs1000719986 -- 62,813,854(+) TCCTG(G/T)CCTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OGFR Gene

Variant ID Type Subtype PubMed ID
esv2722837 CNV deletion 23290073
nsv1073081 CNV deletion 25765185
nsv1144941 CNV deletion 24896259
nsv428380 CNV loss 18775914
nsv459065 CNV gain 19166990
nsv470558 CNV loss 18288195
nsv586496 CNV gain 21841781
nsv834027 CNV loss 17160897
nsv953302 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for OGFR Gene

Gene Damage Index Score: 4.86; 67.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OGFR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OGFR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFR Gene

Disorders for OGFR Gene

Relevant External Links for OGFR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OGFR

No disorders were found for OGFR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OGFR Gene

Publications for OGFR Gene

  1. Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. (PMID: 10677613) Zagon I.S. … McLaughlin P.J. (Brain Res. 2000) 2 3 4 22 64
  2. The biology of the opioid growth factor receptor (OGFr). (PMID: 11890982) Zagon I.S. … McLaughlin P.J. (Brain Res. Brain Res. Rev. 2002) 3 4 22 64
  3. Antagonism of the Met5-enkephalin-opioid growth factor receptor-signaling axis promotes MSC to differentiate into osteoblasts. (PMID: 26687326) Thakur N.A. … Margulies B.S. (J. Orthop. Res. 2016) 2 3 64
  4. The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer. (PMID: 19923357) Avella D.M. … Staveley-O'Carroll K.F. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010) 3 22 64
  5. Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers. (PMID: 19675283) Zagon I.S. … McLaughlin P.J. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009) 3 22 64

Products for OGFR Gene

Sources for OGFR Gene

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