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Aliases & Descriptions for OGFR
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 7-60 1 | | OGFr 3 | | OTTHUMP00000031503 2 |
| | | Descriptions |
|---|
| 7-60 protein 2, 3 | | Zeta-type opioid receptor 2, 3 | | opioid growth factor receptor 2 |
|
| | Search outside databases for aliases for OGFR genePrevious GC identifers: GC20P061313 GC20P062115 GC20P062162 |
Summaries for OGFR(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for OGFR: The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq] UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2Function: Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulationGene Wiki entry for OGFR (OGFr) |
Genomic Location for OGFR
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OGFR gene 
Entrez Gene cytogenetic band: 20q13.3 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.3OGFR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P060906:
(about GC identifiers)
Start:
|
60,906,622 bp from pter |
End:
|
60,915,797 bp from pter |
Size:
|
9,176 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000020.9 NT_011333.5
| Proteins for OGFR
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2 (See
protein sequence)Recommended Name: Opioid growth factor receptor Size: 677 amino acids; 73325 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=The OGF/OGFR complex is probably translocated to the nucleus
Sequence caution: Sequence=AAD03737.1; Type=Frameshift; Positions=1, 181; Sequence=AAD03745.1; Type=Frameshift; Positions=1, 181; Sequence=CAC28882.1; Type=Erroneous gene model prediction;
Secondary accessions: O96029 Q4VXW5 Q96CM2 Q9BQW1 Q9H4H0 Q9H7J5 Q9NZT3 Q9NZT4Alternative splicing: 2 isoforms: Q9NZT2-1 Q9NZT2-2 Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_031372.2
ENSEMBL proteins: ENSP00000359499 ENSP00000349686 ENSP00000290291 ENSP00000359500 ENSP00000359491
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for OGFR: Assays for OGFR: | Protein
Domains/ Families for OGFR(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NZT2
ProtoNet protein and cluster: Q9NZT2 1 Blocks protein family: IPB006757 Opioid growth factor receptor (OGFr) conserved region
UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2Similarity: Belongs to the opioid growth factor receptor family | Gene Function for OGFR
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007346
Applied Biosystems Silencer® siRNAs for OGFR
Sigma-Aldrich siRNA and siRNA Panels for OGFR  Sigma-Aldrich shRNA for OGFR  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007346                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007346                                  untagged cDNA clone in CMV expression vector: NM_007346 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007346
UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2Function: Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation1 MGI phenotypic allele for Ogfr (no phenotypes)
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for OGFR
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Interacting proteins for OGFR (ENSP000002902913) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for OGFR(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for OGFR
|
Transcripts for OGFR(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007346
Sigma-Aldrich siRNA and siRNA Panels for OGFR  Sigma-Aldrich shRNA for OGFR  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_007346 REFSEQ mRNAs for OGFR gene: NM_007346.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007346               OriGene GFP tagged cDNA clone in CMV expression vector: NM_007346                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007346                                  untagged cDNA clone in CMV expression vector: NM_007346  Additional cDNA sequence: AF109134.1 AF172449.1 AF172450.1 AF172451.1 AF172452.1 AF172453.1 AK022234.1 AK314696.1 BC008768.2 BC014137.2 BC032666.1 17 DOTS entries: DT.100774374 DT.75153574 DT.100774376 DT.100774380 DT.100774373 DT.100680511 DT.100774382 DT.91727063 DT.100774377 DT.120821617 DT.421390 DT.102830219 DT.120821608 DT.120821623 DT.120821639 DT.95198481 DT.95198510 24/201 AceView cDNA sequences (see all 201
):CK906337 BM555341 BM755951 BM914572 CA433738 BU623154 BU632622 BQ051449 CA454373 BM126905 BG121198 AU121661 BU181115 AW118282 BM562128 BM470017 CB216777 BM551600 BM723315 AL534308 CN482202 CD673049 CA391380 AI468339
highest scoring ESTs for OGFR:AF109134 AA076652 AA293408 AA399477 AA534510 AA641426 AA865212 AA985306 AF172451 AF172452 Unigene Cluster for OGFR: Opioid growth factor receptor Hs.67896 [show with all ESTs]Unigene Representative Sequence: AF172453
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OGFR (see all 6
)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | |
| SP1: | |   | - |   | - |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for OGFR
5 Ensembl transcripts including schematic representations: ENST00000370468
ENST00000357163
ENST00000290291
ENST00000370469
ENST00000370461
|
Expression for OGFR
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OGFR expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OGFR
1 / 2 / 3 9 probe-sets matching OGFR gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACCCACAGTG
SOURCE GeneReport for Unigene cluster: Hs.67896
Expression variation in blood from EXPOLDB for OGFR UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2Tissue specificity: Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney |
Orthologs for OGFR
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OGFR gene from 5/9 species (see all 9
)
About this table Species with no ortholog for OGFR
ENSEMBL Gene Tree for OGFR | Paralogs for OGFR(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for OGFR gene
- OGFRL12
|
SNPs/Variants for OGFR(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OGFR (up to first 250kb)
|
Disorders & Mutations for OGFR
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606459
6 Novoseek disease relationships for OGFR gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoma squamous cell |
58.79 |
18 |
9121309 (2), 12655527 (2), 16685459 (2), 18813788 (2) (see all 10) |
| pancreatic cancer |
41.49 |
10 |
17332915 (3), 18636152 (3), 10601579 (1) |
| tumors |
33.62 |
61 |
12655527 (6), 16685459 (5), 18813788 (3), 12747745 (3) (see all 13) |
| cancer |
26.80 |
2 |
12747745 (1), 10569617 (1) |
| colon cancer |
26.17 |
6 |
16820893 (2), 8760211 (2) |
| adenocarcinoma |
0.00 |
1 |
10601579 (1) |
About this table
|
Medical News for OGFR(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OGFR (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/48 PubMed articles for OGFR gene (see all 48
):- Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. (PubMed id 10677613)1, 2, 3, 4 Zagon I.S.... McLaughlin P.J. (2000)
- The biology of the opioid growth factor receptor (OGFr). (PubMed id 11890982)1, 3, 4 Zagon I.S.... McLaughlin P.J. (2002)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)3, 4 Deloukas P....Rogers J. (2001)
- Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)3, 4 Hattori A.... Ohara O. (2000)
- Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor. (PubMed id 16685459)1, 3 McLaughlin P.J. and Zagon I.S. (2006)
- Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck. (PubMed id 17273790)1, 3 McLaughlin P.J....Zagon I.S. (2007)
- Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor. (PubMed id 18636152)1, 3 Zagon I.S....McLaughlin P.J. (2008)
- Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers. (PubMed id 16820893)1, 3 Zagon I.S. and McLaughlin P.J. (2006)
|
Search for OGFR
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OGFR
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OGFR
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OGFR(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/OGFr |
|
| | | About This Section
| --
| Services for OGFR(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OGFR:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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