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OGFR Gene

protein-coding   GIFtS: 54

GC20P060906
opioid growth factor receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
7-60 1
OGFr 3
OTTHUMP00000031503 2
Descriptions
7-60 protein 2, 3
Zeta-type opioid receptor 2, 3
opioid growth factor receptor 2
External Ids
HGNC: 157681
Entrez Gene: 110542
UniProtKB: Q9NZT23
Ensembl: ENSG000000604917
Search outside databases for aliases for OGFR gene

Previous GC identifers: GC20P061313 GC20P062115 GC20P062162

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OGFR:
The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as
[Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in
a variety of processes. The encoded unbound receptor for OGF has been localized to the outer
nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of
this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several
transcripts containing between zero and eight repeat units have been reported. [provided by
RefSeq]

UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2
Function: Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be
involved in growth regulation

Gene Wiki entry for OGFR (OGFr)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OGFR gene  

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

OGFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P060906:     (about GC identifiers)

Start:
60,906,622 bp from pter
End:
60,915,797 bp from pter
Size:
9,176 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000020.9  NT_011333.5  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2 (See protein sequence)
Recommended Name: Opioid growth factor receptor  
Size: 677 amino acids; 73325 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=The OGF/OGFR complex
is probably translocated to the nucleus
Sequence caution: Sequence=AAD03737.1; Type=Frameshift; Positions=1, 181; Sequence=AAD03745.1;
Type=Frameshift; Positions=1, 181; Sequence=CAC28882.1; Type=Erroneous gene model prediction;
Secondary accessions: O96029 Q4VXW5 Q96CM2 Q9BQW1 Q9H4H0 Q9H7J5 Q9NZT3 Q9NZT4
Alternative splicing: 2 isoforms:  Q9NZT2-1   Q9NZT2-2   

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_031372.2  

    ENSEMBL proteins: 
    ENSP00000359499 ENSP00000349686 ENSP00000290291 ENSP00000359500 ENSP00000359491 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Zeta Opioid Receptor)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0016020 membrane IEA--
    About this table

    Antibodies for OGFR: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for OGFR
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Zeta Opioid Receptor), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (OGFR)
    Novus Biologicals Antibody for OGFR

    Assays for OGFR: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR006757 OGF_rcpt
     IPR006770 OGF_rcpt_rpt


       GeneDecks  OGFR for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9NZT2

    ProtoNet protein and cluster: Q9NZT2

    1 Blocks protein family: IPB006757 Opioid growth factor receptor (OGFr) conserved region

    UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2
    Similarity: Belongs to the opioid growth factor receptor family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (OGFR)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (OGFR)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007346

                  Applied Biosystems Silencer® siRNAs for OGFR

                  Sigma-Aldrich siRNA and siRNA Panels for OGFR  
                         Sigma-Aldrich shRNA for OGFR  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for OGFR
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007346
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007346
                                     untagged cDNA clone in CMV expression vector: NM_007346 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_007346

    UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2
    Function: Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be
    involved in growth regulation

    1 MGI phenotypic allele for Ogfr (no phenotypes)


    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004985 opioid receptor activity NAS10677613
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    3 Interacting proteins for OGFR (ENSP000002902913) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PENKENSP000003242483STRING (score=.908)
    PNOCENSP000003019083STRING (score=.798)
    PDYNENSP000002173053STRING (score=.794)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558 regulation of cell growth NAS10677613
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for OGFR

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (OGFR)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (OGFR)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007346

                  Sigma-Aldrich siRNA and siRNA Panels for OGFR  
                         Sigma-Aldrich shRNA for OGFR  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_007346  

    REFSEQ mRNAs for OGFR gene: 

    NM_007346.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_007346  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007346
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007346
                                     untagged cDNA clone in CMV expression vector: NM_007346 

    Additional cDNA sequence: 

    AF109134.1 AF172449.1 AF172450.1 AF172451.1 AF172452.1 AF172453.1 AK022234.1 AK314696.1 
    BC008768.2 BC014137.2 BC032666.1 

    17 DOTS entries:

    DT.100774374  DT.75153574  DT.100774376  DT.100774380  DT.100774373  DT.100680511  DT.100774382  DT.91727063 
    DT.100774377  DT.120821617  DT.421390  DT.102830219  DT.120821608  DT.120821623  DT.120821639  DT.95198481 
    DT.95198510 

    24/201 AceView cDNA sequences (see all 201 ):

    CK906337 BM555341 BM755951 BM914572 CA433738 BU623154 BU632622 BQ051449 
    CA454373 BM126905 BG121198 AU121661 BU181115 AW118282 BM562128 BM470017 
    CB216777 BM551600 BM723315 AL534308 CN482202 CD673049 CA391380 AI468339 

    highest scoring ESTs for OGFR:

    AF109134 AA076652 AA293408 AA399477 AA534510 AA641426 AA865212 AA985306 AF172451 AF172452 

    Unigene Cluster for OGFR:

    Opioid growth factor receptor
    Hs.67896  [show with all ESTs]
    Unigene Representative Sequence: AF172453


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OGFR (see all 6 )

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:        -     -           -                 -                                       
    SP2:        -     -           -                 -                                       
    SP3:                                            -                                       
    SP4:                                                                                    
    SP5:        -     -                                                                     

    About this scheme

    ECgene alternative splicing isoforms for OGFR

    5 Ensembl transcripts including schematic representations:
    ENST00000370468  ENST00000357163  ENST00000290291  ENST00000370469  ENST00000370461  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    OGFR expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for OGFR

    1 / 2 / 3

    9 probe-sets matching OGFR gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    40332_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AF109134 1.00 1.00 1.00 1

    202841_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_007346 0.60 1.00 0.82 1

    210443_x_at2, 3 U133-A 1 1.00 1.00 -- -- AF172452 0.80 1.00 0.91 1

    211512_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF172450 0.60 1.00 0.82 1

    211513_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF172449 0.60 1.00 0.82 1

    202841_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    210443_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    211512_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    211513_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACCCACAGTG

    SOURCE GeneReport for Unigene cluster: Hs.67896

    Expression variation in blood from EXPOLDB for OGFR

    UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2
    Tissue specificity: Highly expressed in the heart and liver, moderately in skeletal muscle and
    kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver
    and kidney

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for OGFR gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    OGFR1   -- opioid growth factor receptor 76.41(n)
    70.27(a)
    485964  XM_543089.2  XP_543089.2 
    chimpanzee
    (Pan troglodytes)
    OGFR1   -- opioid growth factor receptor 98.31(n)
    97.47(a)
    458394  XM_514771.2  XP_514771.2 
    cow
    (Bos taurus)
    OGFR1   -- opioid growth factor receptor 76.84(n)
    65.73(a)
    767947  NM_001077019.1  NP_001070487.1 
    rat
    (Rattus norvegicus)
    Ogfr1   -- opioid growth factor receptor 69.61(n)
    62.61(a)
    83525  NM_053340.1  NP_445792.1 
    mouse
    (Mus musculus)
    Ogfr1, 5 25
    opioid growth factor receptor1, 5 67.3(n)1
    59.33(a)1
    720751  NM_031373.21  NP_113550.21 
     AF3038945  AI4645665  (see all 15)
    About this table        Species with no ortholog for OGFR

    ENSEMBL Gene Tree for OGFR
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for OGFR gene
    OGFRL12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/110 NCBI SNPs in OGFR are shown (see all 110 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 88)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs10488021,2
    C,F,H60915757(+) CTGATA/GCCAAG 1 -- ut31 ese35Minor allele frequency- G:0.39EA MN EU 1982
    --
    rs7417591,2
    A,C,F60915888(+) CCGGCG/TACCGC 1 -- ng311Minor allele frequency- T:0.40MN 184
    --
    rs61223131,2
    A,C60915045(+) GCCCCA/CGCCCA 1 R/S mis1 ese30--------
    --
    rs61223151,2
    A,C60915142(+) CGAGAC/GCCCAT 1 S/T mis10--------
    --
    rs119074271,2
    C60906039(+) tccagC/Gagctg 1 -- ng510--------
    --
    rs10488001,2
    F60915746(+) CTTTTT/CTTAGT 1 -- ut311Minor allele frequency- C:0.24MN 184
    rs110861391,2
    A,C60914315(+) CTGCCC/GCATCC 1 P/P syn10--------
    --
    rs61223141,2
    A,C60915110(+) CGCCCA/GGCAGG 1 P/P syn1 ese30--------
    rs10487921,2
    A,C60911416(+) TGGACG/AGACAA 1 T/T syn1 ese31Minor allele frequency- A:0.00MN 184
    rs32043471,2
    F60914105(+) GCGCCG/ACTGGT 1 P/P syn1 ese31Minor allele frequency- A:0.34MN 184
    About this table

    HapMap Linkage Disequilibrium images for OGFR (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606459

    6 Novoseek disease relationships for OGFR gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 58.79 18 9121309 (2), 12655527 (2), 16685459 (2), 18813788 (2) (see all 10)
    pancreatic cancer 41.49 10 17332915 (3), 18636152 (3), 10601579 (1)
    tumors 33.62 61 12655527 (6), 16685459 (5), 18813788 (3), 12747745 (3) (see all 13)
    cancer 26.80 2 12747745 (1), 10569617 (1)
    colon cancer 26.17 6 16820893 (2), 8760211 (2)
    adenocarcinoma 0.00 1 10601579 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/48 PubMed articles for OGFR gene (see all 48 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 11054 HGNC: 15768 AceView: OGFR Ensembl:ENSG00000060491 euGenes: HUgn11054
    ECgene: OGFR H-InvDB: OGFR
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    Wikipedia http://en.wikipedia.org/wiki/OGFr
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for OGFR:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for OGFR-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for OGFR Antibodies for OGFR
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for OGFR Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
    (Zeta Opioid Receptor)
     Antibodies (Zeta Opioid Receptor)
     Search OriGene for OGFR
     Search Tocris compounds for OGFR




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for OGFR

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