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Aliases for OGFR Gene

Aliases for OGFR Gene

  • Opioid Growth Factor Receptor 2 3 5
  • Zeta-Type Opioid Receptor 4
  • Protein 7-60 4
  • OGFr 4

External Ids for OGFR Gene

Previous GeneCards Identifiers for OGFR Gene

  • GC20P061313
  • GC20P062115
  • GC20P062162
  • GC20P060906
  • GC20P061436
  • GC20P058154

Summaries for OGFR Gene

Entrez Gene Summary for OGFR Gene

  • The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for OGFR Gene

OGFR (Opioid Growth Factor Receptor) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include receptor activity and opioid receptor activity. An important paralog of this gene is OGFRL1.

UniProtKB/Swiss-Prot for OGFR Gene

  • Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.

Gene Wiki entry for OGFR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFR Gene

Genomics for OGFR Gene

Regulatory Elements for OGFR Gene

Enhancers for OGFR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OGFR on UCSC Golden Path with GeneCards custom track

Promoters for OGFR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OGFR on UCSC Golden Path with GeneCards custom track

Genomic Location for OGFR Gene

62,804,825 bp from pter
62,814,000 bp from pter
9,176 bases
Plus strand

Genomic View for OGFR Gene

Genes around OGFR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGFR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFR Gene

Proteins for OGFR Gene

  • Protein details for OGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Opioid growth factor receptor
    Protein Accession:
    Secondary Accessions:
    • O96029
    • Q4VXW5
    • Q96CM2
    • Q9BQW1
    • Q9H4H0
    • Q9H7J5
    • Q9NZT3
    • Q9NZT4

    Protein attributes for OGFR Gene

    677 amino acids
    Molecular mass:
    73325 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD03737.1; Type=Frameshift; Positions=1, 181; Evidence={ECO:0000305}; Sequence=AAD03745.1; Type=Frameshift; Positions=1, 181; Evidence={ECO:0000305}; Sequence=CAC28882.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for OGFR Gene


neXtProt entry for OGFR Gene

Proteomics data for OGFR Gene at MOPED

Post-translational modifications for OGFR Gene

  • Ubiquitination at Lys 158, Lys 218, and Lys 291
  • Modification sites at PhosphoSitePlus

Other Protein References for OGFR Gene

No data available for DME Specific Peptides for OGFR Gene

Domains & Families for OGFR Gene

Protein Domains for OGFR Gene

Suggested Antigen Peptide Sequences for OGFR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the opioid growth factor receptor family.
  • Belongs to the opioid growth factor receptor family.
genes like me logo Genes that share domains with OGFR: view

No data available for Gene Families for OGFR Gene

Function for OGFR Gene

Molecular function for OGFR Gene

UniProtKB/Swiss-Prot Function:
Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.
genes like me logo Genes that share phenotypes with OGFR: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OGFR

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGFR Gene

Localization for OGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGFR Gene

Cytoplasm. Nucleus. Note=The OGF/OGFR complex is probably translocated to the nucleus.

Subcellular locations from

Jensen Localization Image for OGFR Gene COMPARTMENTS Subcellular localization image for OGFR gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OGFR: view

Pathways & Interactions for OGFR Gene

genes like me logo Genes that share pathways with OGFR: view

Gene Ontology (GO) - Biological Process for OGFR Gene


No data available for SIGNOR curated interactions for OGFR Gene

Drugs & Compounds for OGFR Gene

(1) Drugs for OGFR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with OGFR: view

Transcripts for OGFR Gene

Unigene Clusters for OGFR Gene

Opioid growth factor receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OGFR Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - - -
SP3: -
SP5: - -
SP6: -

Relevant External Links for OGFR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OGFR Gene

mRNA expression in normal human tissues for OGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OGFR Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for OGFR Gene

This gene is overexpressed in Lymph node (12.6), Peripheral blood mononuclear cells (11.2), Blymphocyte (8.1), and Monocytes (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OGFR Gene

SOURCE GeneReport for Unigene cluster for OGFR Gene Hs.67896

mRNA Expression by UniProt/SwissProt for OGFR Gene

Tissue specificity: Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.
genes like me logo Genes that share expression patterns with OGFR: view

Protein tissue co-expression partners for OGFR Gene

- Elite partner

Primer Products

Orthologs for OGFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGFR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OGFR 35
  • 77.73 (n)
  • 67.59 (a)
  • 57 (a)
(Canis familiaris)
Mammalia OGFR 35
  • 85.89 (n)
  • 84.23 (a)
  • 63 (a)
(Mus musculus)
Mammalia Ogfr 35
  • 71.27 (n)
  • 64.27 (a)
Ogfr 16
Ogfr 36
  • 51 (a)
(Pan troglodytes)
Mammalia OGFR 35
  • 97.08 (n)
  • 95.29 (a)
  • 90 (a)
(Rattus norvegicus)
Mammalia Ogfr 35
  • 71.23 (n)
  • 63.14 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
-- 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia OGFR 36
  • 50 (a)
(Gallus gallus)
Aves OGFR 35
  • 51.18 (n)
  • 45.75 (a)
  • 41 (a)
(Anolis carolinensis)
Reptilia OGFR 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17622 35
(Danio rerio)
Actinopterygii ogfr 36
  • 33 (a)
OGFR (3 of 4) 36
  • 39 (a)
OGFR (4 of 4) 36
  • 28 (a)
ogfrl2 36
  • 31 (a)
Species with no ortholog for OGFR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFR Gene

Gene Tree for OGFR (if available)
Gene Tree for OGFR (if available)

Paralogs for OGFR Gene

Paralogs for OGFR Gene

(1) SIMAP similar genes for OGFR Gene using alignment to 3 proteins: Pseudogenes for OGFR Gene

genes like me logo Genes that share paralogs with OGFR: view

Variants for OGFR Gene

Sequence variations from dbSNP and Humsavar for OGFR Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6122315 - 62,813,345(+) CGAGA(C/G)CCCAT reference, missense
rs6122313 - 62,813,248(+) GCCCC(A/C/T)GCCCA reference, missense
rs1048792 -- 62,809,619(+) TGGAC(A/G)GACAA reference, synonymous-codon
rs1048798 -- 62,813,889(+) CCCTG(C/G)GCCCC utr-variant-3-prime
rs1048799 -- 62,813,916(+) CCCTT(C/T)TGGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OGFR Gene

Variant ID Type Subtype PubMed ID
dgv4603n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913073 CNV Loss 21882294
nsv428380 CNV Loss 18775914
dgv4614n71 CNV Loss 21882294
nsv470558 CNV Loss 18288195
nsv834027 CNV Loss 17160897
nsv9825 CNV Gain 18304495
nsv913124 CNV Loss 21882294
nsv913125 CNV Loss 21882294
nsv913126 CNV Loss 21882294
esv2722837 CNV Deletion 23290073

Variation tolerance for OGFR Gene

Gene Damage Index Score: 4.86; 67.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OGFR Gene

Disorders for OGFR Gene

Relevant External Links for OGFR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OGFR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OGFR Gene

Publications for OGFR Gene

  1. Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. (PMID: 10677613) Zagon I.S. … McLaughlin P.J. (Brain Res. 2000) 2 3 4 23 67
  2. The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer. (PMID: 19923357) Avella D.M. … Staveley-O'Carroll K.F. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010) 3 23
  3. The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation. (PMID: 18923142) Cheng F. … Zagon I.S. (Mol. Biol. Cell 2009) 3 23
  4. Dependence on nuclear localization signals of the opioid growth factor receptor in the regulation of cell proliferation. (PMID: 19244545) Cheng F. … Zagon I.S. (Exp. Biol. Med. (Maywood) 2009) 3 23
  5. Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis. (PMID: 19297547) Donahue R.N. … Zagon I.S. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009) 3 23

Products for OGFR Gene

Sources for OGFR Gene