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Aliases for OGFOD3 Gene

Aliases for OGFOD3 Gene

  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 3 2 3
  • C17orf101 3 4
  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain-Containing Protein 3 3
  • PKHD Domain-Containing Transmembrane Protein C17orf101 3
  • Chromosome 17 Open Reading Frame 101 2
  • EC 1.14.11.- 4

External Ids for OGFOD3 Gene

Previous HGNC Symbols for OGFOD3 Gene

  • C17orf101

Previous GeneCards Identifiers for OGFOD3 Gene

  • GC17M080351
  • GC17M080353

Summaries for OGFOD3 Gene

GeneCards Summary for OGFOD3 Gene

OGFOD3 (2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFOD3 Gene

Genomics for OGFOD3 Gene

Genomic Location for OGFOD3 Gene

Start:
82,389,210 bp from pter
End:
82,418,637 bp from pter
Size:
29,428 bases
Orientation:
Minus strand

Genomic View for OGFOD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OGFOD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFOD3 Gene

No data available for Regulatory Elements for OGFOD3 Gene

Proteins for OGFOD3 Gene

  • Protein details for OGFOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PK18-OGFD3_HUMAN
    Recommended name:
    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3
    Protein Accession:
    Q6PK18
    Secondary Accessions:
    • C9JDC8
    • Q8IZ37
    • Q9H6J2

    Protein attributes for OGFOD3 Gene

    Size:
    319 amino acids
    Molecular mass:
    35646 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Cofactor:
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OGFOD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGFOD3 Gene

Proteomics data for OGFOD3 Gene at MOPED

Post-translational modifications for OGFOD3 Gene

  • Glycosylation at Asn215
  • Modification sites at PhosphoSitePlus

Other Protein References for OGFOD3 Gene

No data available for DME Specific Peptides for OGFOD3 Gene

Domains for OGFOD3 Gene

Protein Domains for OGFOD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PK18

UniProtKB/Swiss-Prot:

OGFD3_HUMAN :
  • Q6PK18
Domain:
  • Contains 1 Fe2OG dioxygenase domain.
Family:
  • Belongs to the OGFOD3 family.
genes like me logo Genes that share domains with OGFOD3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for OGFOD3 Gene

Function for OGFOD3 Gene

Enzyme Numbers (IUBMB) for OGFOD3 Gene

Gene Ontology (GO) - Molecular Function for OGFOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA --
GO:0031418 L-ascorbic acid binding IEA --
genes like me logo Genes that share ontologies with OGFOD3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OGFOD3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OGFOD3 Gene

Localization for OGFOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGFOD3 Gene

Membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for OGFOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with OGFOD3: view

No data available for Subcellular locations from COMPARTMENTS for OGFOD3 Gene

Pathways for OGFOD3 Gene

SuperPathways for OGFOD3 Gene

No Data Available

Interacting Proteins for OGFOD3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000330075%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000330075 Q6PK18-OGFD3_HUMAN for OGFOD3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OGFOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with OGFOD3: view

No data available for Pathways by source for OGFOD3 Gene

Transcripts for OGFOD3 Gene

Unigene Clusters for OGFOD3 Gene

2-oxoglutarate and iron-dependent oxygenase domain containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OGFOD3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGFOD3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - -
SP7:

Relevant External Links for OGFOD3 Gene

GeneLoc Exon Structure for
OGFOD3
ECgene alternative splicing isoforms for
OGFOD3

Expression for OGFOD3 Gene

mRNA expression in normal human tissues for OGFOD3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OGFOD3 Gene

SOURCE GeneReport for Unigene cluster for OGFOD3 Gene Hs.187505

genes like me logo Genes that share expressions with OGFOD3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OGFOD3 Gene

Orthologs for OGFOD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OGFOD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGFOD3 35
  • 98.85 (n)
  • 98.43 (a)
OGFOD3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OGFOD3 35
  • 83.23 (n)
  • 84.71 (a)
OGFOD3 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OGFOD3 35
  • 84.39 (n)
  • 86.62 (a)
OGFOD3 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ogfod3 35
  • 81.32 (n)
  • 85.35 (a)
Ogfod3 16
Ogfod3 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OGFOD3 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGFOD3 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ogfod3 35
  • 82.06 (n)
  • 84.08 (a)
chicken
(Gallus gallus)
Aves LOC769717 35
  • 73.72 (n)
  • 78.14 (a)
OGFOD3 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGFOD3 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3868 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ogfod3 35
  • 69.4 (n)
  • 72.39 (a)
Str.15494 35
zebrafish
(Danio rerio)
Actinopterygii OGFOD3 36
  • 53 (a)
OneToOne
zgc:195081 35
  • 59.25 (n)
  • 57.1 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009177 35
  • 59.4 (n)
  • 51.85 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11708 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for OGFOD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFOD3 Gene

ENSEMBL:
Gene Tree for OGFOD3 (if available)
TreeFam:
Gene Tree for OGFOD3 (if available)

Paralogs for OGFOD3 Gene

No data available for Paralogs for OGFOD3 Gene

Variants for OGFOD3 Gene

Sequence variations from dbSNP and Humsavar for OGFOD3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11903 -- 82,392,455(+) ATGGT(A/G)ATGGC reference, synonymous-codon, utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs4077609 -- 82,393,552(-) CCACA(C/G)GGTCC intron-variant
rs4789768 -- 82,408,481(+) GCCGG(C/T)GGTGG intron-variant
rs4789769 -- 82,415,576(+) AGCCA(C/T)GGCCT synonymous-codon, reference, nc-transcript-variant
rs6502105 -- 82,393,674(+) TCGAG(C/G)CTGAG intron-variant

Relevant External Links for OGFOD3 Gene

HapMap Linkage Disequilibrium report
OGFOD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OGFOD3 Gene

Disorders for OGFOD3 Gene

No disorders were found for OGFOD3 Gene.

No data available for UniProtKB/Swiss-Prot for OGFOD3 Gene

Publications for OGFOD3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for OGFOD3 Gene

Sources for OGFOD3 Gene

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