Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OGFOD3 Gene

Aliases for OGFOD3 Gene

  • 2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 3 2 3
  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 3 2 3 5
  • C17orf101 3 4
  • PKHD Domain-Containing Transmembrane Protein C17orf101 3
  • Chromosome 17 Open Reading Frame 101 2
  • EC 1.14.11.- 4

External Ids for OGFOD3 Gene

Previous HGNC Symbols for OGFOD3 Gene

  • C17orf101

Previous GeneCards Identifiers for OGFOD3 Gene

  • GC17M080351
  • GC17M080353

Summaries for OGFOD3 Gene

GeneCards Summary for OGFOD3 Gene

OGFOD3 (2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFOD3 Gene

Genomics for OGFOD3 Gene

Regulatory Elements for OGFOD3 Gene

Promoters for OGFOD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OGFOD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OGFOD3 Gene

Chromosome:
17
Start:
82,389,210 bp from pter
End:
82,418,637 bp from pter
Size:
29,428 bases
Orientation:
Minus strand

Genomic View for OGFOD3 Gene

Genes around OGFOD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGFOD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGFOD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFOD3 Gene

Proteins for OGFOD3 Gene

  • Protein details for OGFOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PK18-OGFD3_HUMAN
    Recommended name:
    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3
    Protein Accession:
    Q6PK18
    Secondary Accessions:
    • C9JDC8
    • Q8IZ37
    • Q9H6J2

    Protein attributes for OGFOD3 Gene

    Size:
    319 amino acids
    Molecular mass:
    35646 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Cofactor:
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OGFOD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGFOD3 Gene

Proteomics data for OGFOD3 Gene at MOPED

Post-translational modifications for OGFOD3 Gene

  • Glycosylation at Asn 215
  • Modification sites at PhosphoSitePlus

Other Protein References for OGFOD3 Gene

No data available for DME Specific Peptides for OGFOD3 Gene

Domains & Families for OGFOD3 Gene

Protein Domains for OGFOD3 Gene

Suggested Antigen Peptide Sequences for OGFOD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PK18

UniProtKB/Swiss-Prot:

OGFD3_HUMAN :
  • Contains 1 Fe2OG dioxygenase domain.
  • Belongs to the OGFOD3 family.
Domain:
  • Contains 1 Fe2OG dioxygenase domain.
Family:
  • Belongs to the OGFOD3 family.
genes like me logo Genes that share domains with OGFOD3: view

No data available for Gene Families for OGFOD3 Gene

Function for OGFOD3 Gene

Enzyme Numbers (IUBMB) for OGFOD3 Gene

Gene Ontology (GO) - Molecular Function for OGFOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
genes like me logo Genes that share ontologies with OGFOD3: view
genes like me logo Genes that share phenotypes with OGFOD3: view

Animal Models for OGFOD3 Gene

MGI Knock Outs for OGFOD3:

Animal Model Products

CRISPR Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OGFOD3 Gene

Localization for OGFOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGFOD3 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OGFOD3 Gene COMPARTMENTS Subcellular localization image for OGFOD3 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for OGFOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OGFOD3: view

Pathways & Interactions for OGFOD3 Gene

SuperPathways for OGFOD3 Gene

No Data Available

Interacting Proteins for OGFOD3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000330075%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q6PK18-OGFD3_HUMAN ENSP00000330075 for OGFOD3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for OGFOD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OGFOD3 Gene

Drugs & Compounds for OGFOD3 Gene

No Compound Related Data Available

Transcripts for OGFOD3 Gene

Unigene Clusters for OGFOD3 Gene

2-oxoglutarate and iron-dependent oxygenase domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OGFOD3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - -
SP7:

Relevant External Links for OGFOD3 Gene

GeneLoc Exon Structure for
OGFOD3
ECgene alternative splicing isoforms for
OGFOD3

Expression for OGFOD3 Gene

mRNA expression in normal human tissues for OGFOD3 Gene

Protein differential expression in normal tissues from HIPED for OGFOD3 Gene

This gene is overexpressed in Bone (27.6), Testis (7.7), and Adrenal (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for OGFOD3 Gene



SOURCE GeneReport for Unigene cluster for OGFOD3 Gene Hs.187505

genes like me logo Genes that share expression patterns with OGFOD3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OGFOD3 Gene

Orthologs for OGFOD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OGFOD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGFOD3 36
  • 98 (a)
OneToOne
OGFOD3 35
  • 98.85 (n)
  • 98.43 (a)
cow
(Bos Taurus)
Mammalia OGFOD3 35
  • 83.23 (n)
  • 84.71 (a)
OGFOD3 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OGFOD3 36
  • 76 (a)
OneToOne
OGFOD3 35
  • 84.39 (n)
  • 86.62 (a)
mouse
(Mus musculus)
Mammalia Ogfod3 36
  • 75 (a)
OneToOne
Ogfod3 16
Ogfod3 35
  • 81.32 (n)
  • 85.35 (a)
oppossum
(Monodelphis domestica)
Mammalia OGFOD3 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGFOD3 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ogfod3 35
  • 82.06 (n)
  • 84.08 (a)
chicken
(Gallus gallus)
Aves LOC769717 35
  • 73.72 (n)
  • 78.14 (a)
OGFOD3 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGFOD3 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3868 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ogfod3 35
  • 69.4 (n)
  • 72.39 (a)
Str.15494 35
zebrafish
(Danio rerio)
Actinopterygii zgc:195081 35
  • 59.25 (n)
  • 57.1 (a)
OGFOD3 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009177 35
  • 59.4 (n)
  • 51.85 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11708 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for OGFOD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFOD3 Gene

ENSEMBL:
Gene Tree for OGFOD3 (if available)
TreeFam:
Gene Tree for OGFOD3 (if available)

Paralogs for OGFOD3 Gene

No data available for Paralogs for OGFOD3 Gene

Variants for OGFOD3 Gene

Sequence variations from dbSNP and Humsavar for OGFOD3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs8072110 - 82,415,501(+) CCGTC(A/G/T)TCGGC nc-transcript-variant, reference, missense
VAR_039949 -
rs7213338 -- 82,399,544(+) CAATG(C/T)TGTGC intron-variant
rs8067189 -- 82,408,938(+) CAGCT(A/C)GGAAG intron-variant
rs7503819 -- 82,393,763(+) TCTCT(A/G)CTGCT intron-variant

Variation tolerance for OGFOD3 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OGFOD3 Gene

HapMap Linkage Disequilibrium report
OGFOD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OGFOD3 Gene

Disorders for OGFOD3 Gene

Relevant External Links for OGFOD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OGFOD3

No disorders were found for OGFOD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OGFOD3 Gene

Publications for OGFOD3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3

Products for OGFOD3 Gene

Sources for OGFOD3 Gene

Back to Top

Content