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Aliases for OGFOD2 Gene

Aliases for OGFOD2 Gene

  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 2 2 3
  • EC 1.14.11.- 4

External Ids for OGFOD2 Gene

Summaries for OGFOD2 Gene

GeneCards Summary for OGFOD2 Gene

OGFOD2 (2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFOD2 Gene

Genomics for OGFOD2 Gene

Genomic Location for OGFOD2 Gene

Start:
122,974,580 bp from pter
End:
122,980,043 bp from pter
Size:
5,464 bases
Orientation:
Plus strand

Genomic View for OGFOD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OGFOD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFOD2 Gene

Regulatory Elements for OGFOD2 Gene

Transcription factor binding sites by QIAGEN in the OGFOD2 gene promoter:

Proteins for OGFOD2 Gene

  • Protein details for OGFOD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N063-OGFD2_HUMAN
    Recommended name:
    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
    Protein Accession:
    Q6N063
    Secondary Accessions:
    • B3KT24
    • Q4KN13
    • Q6N023
    • Q9H8K6

    Protein attributes for OGFOD2 Gene

    Size:
    350 amino acids
    Molecular mass:
    38996 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Cofactor:
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAE45849.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAE45849.1; Type=Frameshift; Positions=104; Evidence={ECO:0000305};

    Alternative splice isoforms for OGFOD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGFOD2 Gene

Proteomics data for OGFOD2 Gene at MOPED

Post-translational modifications for OGFOD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OGFOD2 Gene

Domains for OGFOD2 Gene

Protein Domains for OGFOD2 Gene

Suggested Antigen Peptide Sequences for OGFOD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6N063

UniProtKB/Swiss-Prot:

OGFD2_HUMAN
Domain:
  • Contains 1 Fe2OG dioxygenase domain.:
    • Q6N063
Family:
  • Belongs to the OGFOD2 family.:
    • Q6N063
genes like me logo Genes that share domains with OGFOD2: view

No data available for Gene Families for OGFOD2 Gene

Function for OGFOD2 Gene

Enzyme Numbers (IUBMB) for OGFOD2 Gene

Gene Ontology (GO) - Molecular Function for OGFOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA --
GO:0031418 L-ascorbic acid binding IEA --
genes like me logo Genes that share ontologies with OGFOD2: view

Phenotypes for OGFOD2 Gene

GenomeRNAi human phenotypes for OGFOD2:
genes like me logo Genes that share phenotypes with OGFOD2: view

miRNA for OGFOD2 Gene

miRTarBase miRNAs that target OGFOD2

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for OGFOD2 Gene

Localization for OGFOD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OGFOD2 Gene COMPARTMENTS Subcellular localization image for OGFOD2 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OGFOD2 Gene

Pathways for OGFOD2 Gene

SuperPathways for OGFOD2 Gene

No Data Available

Interacting Proteins for OGFOD2 Gene

Gene Ontology (GO) - Biological Process for OGFOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with OGFOD2: view

No data available for Pathways by source for OGFOD2 Gene

Compounds for OGFOD2 Gene

(2) HMDB Compounds for OGFOD2 Gene

Compound Synonyms Cas Number PubMed IDs
Ascorbic acid
  • (+)-ascorbate
50-81-7
Iron
  • Armco iron
7439-89-6

(1) Drugbank Compounds for OGFOD2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin C
  • Ascorbate
50-81-7 target
genes like me logo Genes that share compounds with OGFOD2: view

Transcripts for OGFOD2 Gene

mRNA/cDNA for OGFOD2 Gene

(7) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(25) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OGFOD2 Gene

2-oxoglutarate and iron-dependent oxygenase domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OGFOD2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: -
SP12: - - - - - - - - - -
SP13: - -
SP14: - - - - - - - -
SP15: - -
SP16:

ExUns: 9c · 9d · 9e ^ 10a · 10b · 10c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for OGFOD2 Gene

GeneLoc Exon Structure for
OGFOD2
ECgene alternative splicing isoforms for
OGFOD2

Expression for OGFOD2 Gene

mRNA expression in normal human tissues for OGFOD2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OGFOD2 Gene

SOURCE GeneReport for Unigene cluster for OGFOD2 Gene Hs.524817

genes like me logo Genes that share expressions with OGFOD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OGFOD2 Gene

Orthologs for OGFOD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OGFOD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGFOD2 35
  • 98.51 (n)
  • 98.62 (a)
OGFOD2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OGFOD2 35
  • 86.92 (n)
  • 90.97 (a)
OGFOD2 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OGFOD2 35
  • 86.23 (n)
  • 89.58 (a)
OGFOD2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ogfod2 35
  • 83.56 (n)
  • 87.15 (a)
Ogfod2 16
Ogfod2 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OGFOD2 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGFOD2 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ogfod2 35
  • 85.07 (n)
  • 88.89 (a)
chicken
(Gallus gallus)
Aves OGFOD2 35
  • 64.91 (n)
  • 62.46 (a)
OGFOD2 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGFOD2 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ogfod2 35
  • 58.6 (n)
  • 58.95 (a)
zebrafish
(Danio rerio)
Actinopterygii ogfod2 35
  • 58.36 (n)
  • 55.68 (a)
ogfod2 36
  • 45 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G22950 35
  • 44.65 (n)
  • 39.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for OGFOD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFOD2 Gene

ENSEMBL:
Gene Tree for OGFOD2 (if available)
TreeFam:
Gene Tree for OGFOD2 (if available)

Paralogs for OGFOD2 Gene

No data available for Paralogs for OGFOD2 Gene

Variants for OGFOD2 Gene

Sequence variations from dbSNP and Humsavar for OGFOD2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs883562 -- 122,976,172(+) CCAAG(C/G)TTTTA intron-variant
rs884956 -- 122,976,415(-) TGAGA(A/G)CCCCT intron-variant
rs5021544 -- 122,974,458(+) CGGGT(A/C)CCTGT upstream-variant-2KB
rs7296418 -- 122,973,072(+) GTCAG(C/T)GCTGG upstream-variant-2KB
rs10548719 -- 122,977,534(+) AACCT(-/CT)GATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OGFOD2 Gene

Variant ID Type Subtype PubMed ID
dgv1497n71 CNV Loss 21882294
nsv517200 CNV Loss 19592680
dgv22n68 CNV Loss 17160897
nsv455732 CNV Loss 19166990
nsv899577 CNV Loss 21882294
nsv899578 CNV Loss 21882294
nsv914 CNV Insertion 18451855

Relevant External Links for OGFOD2 Gene

HapMap Linkage Disequilibrium report
OGFOD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFOD2 Gene

Disorders for OGFOD2 Gene

Relevant External Links for OGFOD2

Genetic Association Database (GAD)
OGFOD2
genes like me logo Genes that share disorders with OGFOD2: view

No data available for UniProtKB/Swiss-Prot for OGFOD2 Gene

Publications for OGFOD2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PMID: 21507922) Ramsuran V. … Ndung'u T. (Clin. Infect. Dis. 2011) 3 48
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for OGFOD2 Gene

Sources for OGFOD2 Gene

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