V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

OGFOD2 Gene

protein-coding   GIFtS: 46

GC12P122025
2-oxoglutarate and iron-dependent oxygenase domain containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for OGFOD2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
DKFZp686H15154 2
EC 1.14.11.- 3
FLJ13491 1, 2
FLJ37501 1, 2
MGC120434 2
MGC120436 2
Descriptions
2-oxoglutarate and iron-dependent oxygenase domain
containing 2 2
External Ids
HGNC: 258231
Entrez Gene: 796762
UniProtKB: Q6N0633
Ensembl: ENSG000001113257
Search outside databases for aliases for OGFOD2 gene

Summaries
for OGFOD2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for OGFOD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OGFOD2 gene  

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

OGFOD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P122025:     (about GC identifiers)

Start:
 122,025,242 bp from pter
End:
 122,030,541 bp from pter
Size:
 5,300 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000012.10  NT_009755.18  

Proteins
for OGFOD2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: OGFD2_HUMAN, Q6N063 (See protein sequence)
Recommended Name: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2  
Size: 350 amino acids; 38996 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Cofactor: Ascorbate (By similarity)
Sequence caution: Sequence=CAE45849.1; Type=Erroneous translation; Note=Wrong choice of frame;
Sequence=CAE45849.1; Type=Frameshift; Positions=104;
Secondary accessions: Q4KN13 Q6N023 Q9H8K6
Alternative splicing: 4 isoforms:  Q6N063-1   Q6N063-2   Q6N063-3   Q6N063-4   

REFSEQ proteins: NP_078899.1  

ENSEMBL proteins: 
ENSP00000228922 ENSP00000380544 ENSP00000384989 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (FLJ13491)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for OGFOD2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Monoclonal and Polyclonal Antibodies from Abnova (FLJ13491)
Novus Biologicals Antibody for OGFOD2

Assays for OGFOD2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for OGFOD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro domains/families:
 IPR006620 Pro_4_hyd_alph
 IPR005123 Oxoglutarate/Fe-dep_Oase


   GeneDecks  OGFOD2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q6N063

ProtoNet protein and cluster: Q6N063

UniProtKB/Swiss-Prot: OGFD2_HUMAN, Q6N063
Similarity: Belongs to the OGFOD2 family
Similarity: Contains 1 PKHD (prolyl/lysyl hydroxylase) domain

Gene Function
for OGFOD2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (OGFOD2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024623

              Applied Biosystems Silencer® siRNAs for OGFOD2

              Sigma-Aldrich siRNA for OGFOD2  
                     Sigma-Aldrich shRNA for OGFOD2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for OGFOD2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024623
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024623
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_024623 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_024623

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0005506 iron ion binding IEA--
GO:0016491 oxidoreductase activity IEA--
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA--
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA--
GO:0031418 L-ascorbic acid binding IEA--
About this table

Pathways & Interactions
for OGFOD2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Sigma-Aldrich "Your Favorite Gene" Pathway for  OGFOD2  (Your Favorite Gene powered by Ingenuity) 
 Lysine Degradation

   GeneDecks  OGFOD2 for the pathways selected above  
About GeneDecksing


2 Interacting proteins for OGFOD2 (Q6N0632) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
EEF1GP266412MINT-65519
KAT5Q929932MINT-65520
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0019538 protein metabolic process IEA--
GO:0055114 oxidation reduction IEA--
About this table

Drugs & Compounds
for OGFOD2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OGFOD2

Transcripts
for OGFOD2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (OGFOD2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024623

              Sigma-Aldrich siRNA for OGFOD2  
                     Sigma-Aldrich shRNA for OGFOD2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_024623  

REFSEQ mRNAs for OGFOD2 gene: 

NM_024623.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_024623  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024623
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024623
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_024623 

Additional cDNA sequence: 

AK023553.1 AK094820.1 AK095481.1 AK303095.1 BC009181.1 BC015605.2 BC033857.1 BC047676.1 
BC071172.1 BC098119.1 BC098293.1 BC101940.1 BC105637.1 BX640675.1 BX640734.1 CR457316.1 
CR610399.1 CR622109.1 

24/26 DOTS entries (see all 26 ):

DT.311841  DT.101984831  DT.311842  DT.101983596  DT.121179283  DT.102835395  DT.101983595  DT.95177500 
DT.91742581  DT.100667619  DT.95211042  DT.100648932  DT.91742584  DT.99967424  DT.100755256  DT.100706926 
DT.100755255  DT.97860696  DT.100648934  DT.102835393  DT.91742587  DT.97823542  DT.100018699  DT.100667620 

1 AceView cDNA sequence:

NM_024623 

highest scoring ESTs for OGFOD2:

AI431902 AA531120 AI025662 AI082157 AI309636 AI569285 AI740858 AK023553 AK094820 AK095481 

Unigene Cluster for OGFOD2:

2-oxoglutarate and iron-dependent oxygenase domain containing 2
Hs.524817  [show with all ESTs]
Unigene Representative Sequence: BC071172


GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for OGFOD2 (see all 16 )

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ·
SP1:                    -     -     -           -                             -     -     -                 -     -     -                                       
SP2:                                                                    -     -     -     -     -     -     -     -           -                                 
SP3:                    -     -     -           -                             -     -     -     -     -     -     -     -     -                                 
SP4:                                            -                             -     -     -     -     -     -     -     -     -                                 
SP5:                    -     -     -           -                             -     -     -     -     -     -     -     -     -     -                           

ExUns: 9c · 9d · 9e ^ 10a · 10b · 10c
SP1:                                    
SP2:                                    
SP3:                                    
SP4:                                    
SP5:                                    

About this scheme

ECgene alternative splicing isoforms for OGFOD2

3 Ensembl transcripts including schematic representations:
ENST00000228922  ENST00000397389  ENST00000406539  

Expression
for OGFOD2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OGFOD2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OGFOD2

1 / 2 / 3

8 probe-sets matching OGFOD2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

82732_at2, 3 U95-D 1 1.00 1.00 0.90 0.94 AA531120 1.00 0.77 0.89 1

44617_at2, 3 U133-B 1 1.00 1.00 0.61 1.06 AI431902 1.00 0.87 0.94 1

219245_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI309636 0.80 0.83 0.82 1

219246_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024623 0.60 0.78 0.69 1

44617_at2, 3 U133-A 1 1.00 1.00 -- -- AI431902 1.00 0.87 0.94 1

219245_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

219246_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

44617_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TGCTGCCGTG

SOURCE GeneReport for Unigene cluster: Hs.524817

Orthologs
for OGFOD2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for OGFOD2 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 OGFOD21   -- 2-oxoglutarate and iron-dependent oxygenase domain more 86.23(n)
89.58(a)		 477455  XM_534653.2  XP_534653.2 
cow
(Bos taurus)		 OGFOD21   -- 2-oxoglutarate and iron-dependent oxygenase domain more 86.92(n)
90.97(a)		 539407  XM_586925.3  XP_586925.2 
rat
(Rattus norvegicus)		 Ogfod21   -- 2-oxoglutarate and iron-dependent oxygenase domain more 85.07(n)
88.89(a)		 288657  XM_213776.4  XP_213776.4 
mouse
(Mus musculus)		 Ogfod21, 5 55
 2-oxoglutarate and iron-dependent oxygenase domain more1, 5 83.56(n)1
87.15(a)1		 666271  NM_025671.21  NP_079947.11 
 AA9808105  AK0049165  (see all 13)
chicken
(Gallus gallus)		 OGFOD21   -- 2-oxoglutarate and iron-dependent oxygenase domain more 64.91(n)
62.46(a)		 416832  XM_415123.2  XP_415123.2 
About this table        Species with no ortholog for OGFOD2

ENSEMBL Gene Tree for OGFOD2

Paralogs
for OGFOD2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for OGFOD2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


3 NCBI SNPs in OGFOD2 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs734088991,2
--122028215(+) TGGGAA/GGCAGA 1 -- int10--------
--
rs339643371,2
--122028036(+) AACCT-/CTGATTC 1 -- int10--------
--
rs105487191,2
--122028035(+) ttaac-/CTctgat 1 -- int10--------
About this table
The following additional 25 SNP(s) have been found in Applied Biosystems data source:
(Click for Applied Biosystems TaqMan ® Genotyping Assay)


 rs60641861 rs884956 rs1568918 rs3782289 rs34437918 rs2049506 rs3759115
 rs4148856 rs1057765 rs12811109 rs1801530 rs34010146 rs36004829 rs1463877
 rs3741530 rs11612594 rs15097 rs7296418 rs35563574 rs12422394 rs10734978
 rs28542899 rs12828755 rs883563 rs35456417

HapMap Linkage Disequilibrium images for OGFOD2 (up to first 250kb)

Disorders & Mutations
for OGFOD2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for OGFOD2

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for OGFOD2

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

5 PubMed articles for OGFOD2 gene:

Search for OGFOD2

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing OGFOD2

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 79676 HGNC: 25823 AceView: FLJ13491 Ensembl:ENSG00000111325 euGenes: HUgn79676
ECgene: OGFOD2 H-InvDB: OGFOD2

Other Databases showing OGFOD2

(According to HUGE)
About This Section

   --

Specialized Databases showing OGFOD2

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for OGFOD2

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for OGFOD2

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OGFOD2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for OGFOD2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for OGFOD2 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OGFOD2 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (FLJ13491)
 Antibodies (FLJ13491)
 Search for Chimera RNAi
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Search for Recombinant Proteins
 Search for Antibodies
 Search OriGene for OGFOD2
 Search Tocris compounds for OGFOD2




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for OGFOD2

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
OGFOD2 Gene at Home site.
Version 2.41.1
server5.xennexinc.com