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Aliases for OGFOD2 Gene

Aliases for OGFOD2 Gene

  • 2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 2 2 3 5
  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 2 2
  • EC 1.14.11.- 4

External Ids for OGFOD2 Gene

Previous GeneCards Identifiers for OGFOD2 Gene

  • GC12P122025
  • GC12P123459
  • GC12P120420

Summaries for OGFOD2 Gene

GeneCards Summary for OGFOD2 Gene

OGFOD2 (2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFOD2 Gene

Genomics for OGFOD2 Gene

Regulatory Elements for OGFOD2 Gene

Enhancers for OGFOD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F123139 1.7 FANTOM5 Ensembl ENCODE 11.2 +167.4 167377 5.3 ARID4B FEZF1 DMAP1 YY1 SLC30A9 GLIS2 FOS SP3 PPARG KAT8 CDK2AP1 VPS37B ENSG00000256092 ENSG00000256028 OGFOD2 ABCB9 ARL6IP4 MPHOSPH9 HIP1R C12orf65
GH12F123074 1.1 Ensembl ENCODE 16.5 +101.8 101821 3.6 PKNOX1 ARID4B FEZF1 ZNF48 RAD21 GLIS2 SCRT2 ZNF207 RCOR1 EGR2 CDK2AP1 OGFOD2 PITPNM2 ABCB9 ARL6IP4 ENSG00000256028 C12orf65 CCDC92 DNAH10OS LOC100507091
GH12F122879 1.5 FANTOM5 ENCODE 11.6 -92.0 -92022 6.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 EIF2B1 VPS37B ZCCHC8 RPL27P12 IL31 LOC100506691 TMED2 MLXIP C12orf65 OGFOD2
GH12F122951 1.3 Ensembl ENCODE 13.2 -22.7 -22698 1.4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 OGFOD2 ABCB9 VPS37B HCAR1
GH12F123033 1.3 Ensembl ENCODE 12.5 +60.6 60647 4.3 PKNOX1 ATF1 MLX ARID4B SIN3A ZNF48 GATA2 FOS SP5 ZHX2 CDK2AP1 MPHOSPH9 ABCB9 OGFOD2 PITPNM2 C12orf65 GC12P123016 LOC100507091
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OGFOD2 on UCSC Golden Path with GeneCards custom track

Promoters for OGFOD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001025161 320 2201 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 GLIS1

Genomic Location for OGFOD2 Gene

Chromosome:
12
Start:
122,974,580 bp from pter
End:
122,980,043 bp from pter
Size:
5,464 bases
Orientation:
Plus strand

Genomic View for OGFOD2 Gene

Genes around OGFOD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGFOD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGFOD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFOD2 Gene

Proteins for OGFOD2 Gene

  • Protein details for OGFOD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N063-OGFD2_HUMAN
    Recommended name:
    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
    Protein Accession:
    Q6N063
    Secondary Accessions:
    • B3KT24
    • Q4KN13
    • Q6N023
    • Q9H8K6

    Protein attributes for OGFOD2 Gene

    Size:
    350 amino acids
    Molecular mass:
    38996 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Cofactor:
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAE45849.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAE45849.1; Type=Frameshift; Positions=104; Evidence={ECO:0000305};

    Alternative splice isoforms for OGFOD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGFOD2 Gene

Post-translational modifications for OGFOD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OGFOD2 Gene

Domains & Families for OGFOD2 Gene

Protein Domains for OGFOD2 Gene

Suggested Antigen Peptide Sequences for OGFOD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6N063

UniProtKB/Swiss-Prot:

OGFD2_HUMAN :
  • Contains 1 Fe2OG dioxygenase domain.
  • Belongs to the OGFOD2 family.
Domain:
  • Contains 1 Fe2OG dioxygenase domain.
Family:
  • Belongs to the OGFOD2 family.
genes like me logo Genes that share domains with OGFOD2: view

No data available for Gene Families for OGFOD2 Gene

Function for OGFOD2 Gene

Enzyme Numbers (IUBMB) for OGFOD2 Gene

Gene Ontology (GO) - Molecular Function for OGFOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0031418 L-ascorbic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OGFOD2: view
genes like me logo Genes that share phenotypes with OGFOD2: view

Animal Model Products

miRNA for OGFOD2 Gene

miRTarBase miRNAs that target OGFOD2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGFOD2 Gene

Localization for OGFOD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGFOD2 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OGFOD2 Gene

Pathways & Interactions for OGFOD2 Gene

SuperPathways for OGFOD2 Gene

No Data Available

Interacting Proteins for OGFOD2 Gene

Gene Ontology (GO) - Biological Process for OGFOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with OGFOD2: view

No data available for Pathways by source and SIGNOR curated interactions for OGFOD2 Gene

Drugs & Compounds for OGFOD2 Gene

(1) Drugs for OGFOD2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin C Approved Nutra Target 514,514

(1) Additional Compounds for OGFOD2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with OGFOD2: view

Transcripts for OGFOD2 Gene

mRNA/cDNA for OGFOD2 Gene

(7) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(25) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OGFOD2 Gene

2-oxoglutarate and iron-dependent oxygenase domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGFOD2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: -
SP12: - - - - - - - - - -
SP13: - -
SP14: - - - - - - - -
SP15: - -
SP16:

ExUns: 9c · 9d · 9e ^ 10a · 10b · 10c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for OGFOD2 Gene

GeneLoc Exon Structure for
OGFOD2
ECgene alternative splicing isoforms for
OGFOD2

Expression for OGFOD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OGFOD2 Gene

Protein differential expression in normal tissues from HIPED for OGFOD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (50.0) and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OGFOD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of OGFOD2 Gene:

OGFOD2

SOURCE GeneReport for Unigene cluster for OGFOD2 Gene:

Hs.524817
genes like me logo Genes that share expression patterns with OGFOD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OGFOD2 Gene

Orthologs for OGFOD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OGFOD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGFOD2 34 35
  • 98.51 (n)
cow
(Bos Taurus)
Mammalia OGFOD2 34 35
  • 86.92 (n)
dog
(Canis familiaris)
Mammalia OGFOD2 34 35
  • 86.23 (n)
rat
(Rattus norvegicus)
Mammalia Ogfod2 34
  • 85.07 (n)
mouse
(Mus musculus)
Mammalia Ogfod2 34 16 35
  • 83.56 (n)
oppossum
(Monodelphis domestica)
Mammalia OGFOD2 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGFOD2 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves OGFOD2 34 35
  • 64.91 (n)
lizard
(Anolis carolinensis)
Reptilia OGFOD2 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ogfod2 34
  • 58.6 (n)
zebrafish
(Danio rerio)
Actinopterygii ogfod2 34 35
  • 58.36 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G22950 34
  • 44.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToOne
Species where no ortholog for OGFOD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFOD2 Gene

ENSEMBL:
Gene Tree for OGFOD2 (if available)
TreeFam:
Gene Tree for OGFOD2 (if available)

Paralogs for OGFOD2 Gene

No data available for Paralogs for OGFOD2 Gene

Variants for OGFOD2 Gene

Sequence variations from dbSNP and Humsavar for OGFOD2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10548719 -- 122,977,536(+) AACCT(-/CT)GATTC intron-variant
rs112253827 -- 122,975,362(+) CAGCA(A/G)CTGCG intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs113315495 -- 122,974,777(+) GGGAC(C/T)CGGGG upstream-variant-2KB, utr-variant-5-prime
rs115152276 -- 122,976,546(+) CTTGG(C/T)TTCCA intron-variant, upstream-variant-2KB
rs11614094 -- 122,973,715(+) aatta(C/G)ccggg intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OGFOD2 Gene

Variant ID Type Subtype PubMed ID
dgv22n68 CNV loss 17160897
nsv455732 CNV loss 19166990
nsv517200 CNV loss 19592680
nsv560492 CNV loss 21841781
nsv914 CNV insertion 18451855

Variation tolerance for OGFOD2 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OGFOD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OGFOD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFOD2 Gene

Disorders for OGFOD2 Gene

Relevant External Links for OGFOD2

Genetic Association Database (GAD)
OGFOD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OGFOD2

No disorders were found for OGFOD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OGFOD2 Gene

Publications for OGFOD2 Gene

  1. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PMID: 21507922) Ramsuran V. … Ndung'u T. (Clin. Infect. Dis. 2011) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64
  5. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3 64

Products for OGFOD2 Gene

Sources for OGFOD2 Gene

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