OGFOD2 Gene
protein-coding GIFtS : 47
GCID: GC12 P123459
2-oxoglutarate and iron-dependent oxygenase domain containing...
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Aliasesfor OGFOD2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases 2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 2 1 2 FLJ134911 FLJ375011 2-Oxoglutarate And Iron-Dependent Oxygenase Domain-Containing Protein 22 EC 1.14.11.-3
Export aliases for OGFOD2 gene to outside databases Previous GC identifers: GC12P122025 GC12P120420
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Summariesfor OGFOD2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor OGFOD2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009755.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OGFOD2 gene promoter: Sp1 Nkx2-5 c-Ets-1 Other transcription factors Search SABiosciences Chromatin IP Primers for OGFOD2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat OGFOD2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31 OGFOD2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P123459: view genomic region
(about GC identifiers )
Start:
123,459,127 bp from pter
End:
123,464,590 bp from pter
Size:
5,464 bases
Orientation:
plus strand
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Proteinsfor OGFOD2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: OGFD2_HUMAN, Q6N063 (See
protein sequence )Recommended Name: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 Size : 350 amino acids; 38996 Da
Cofactor : Binds 1 Fe(2+) ion per subunit (By similarity)
Cofactor : Ascorbate (By similarity)
Sequence caution : Sequence=CAE45849.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=CAE45849.1;Type=Frameshift; Positions=104;
Secondary accessions : B3KT24 Q4KN13 Q6N023 Q9H8K6Alternative splicing : 4 isoforms : Q6N063-1 Q6N063-2 Q6N063-3 Q6N063-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for OGFOD2: NX_Q6N063 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6N063 OGFOD2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_078899.1 ENSEMBL proteins: ENSP00000380544 ENSP00000442817 ENSP00000438327 ENSP00000442476 ENSP00000444436 ENSP00000444608 ENSP00000438192 ENSP00000394175 ENSP00000228922 ENSP00000442083 ENSP00000439667 ENSP00000438003 Human Recombinant Protein Products: OGFOD2 Antibody Products: Assay Products for OGFOD2:
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Protein
Domains / Familiesfor OGFOD2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
OGFOD2 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6N063 ProtoNet protein and cluster: Q6N063
UniProtKB/Swiss-Prot: OGFD2_HUMAN, Q6N063 Similarity : Belongs to the OGFOD2 familySimilarity : Contains 1 Fe2OG dioxygenase domain
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Functionfor OGFOD2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Enzyme Number (IUBMB): EC 1.14.11.- 1 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OGFOD2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OGFOD2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: OGFOD2 (NM_024623 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OGFOD2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OGFOD2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGFOD2
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005506 iron ion binding
IEA -- GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
IEA -- GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
IEA -- GO:0031418 L-ascorbic acid binding
IEA --
OGFOD2 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for OGFOD2 :
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Pathways & Interactionsfor OGFOD2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OGFOD2 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)3 Interacting proteins for OGFOD2 (Q6N063 2 , 3 ENSP00000380544 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor OGFOD2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for OGFOD2 2 HMDB Compounds for OGFOD2 About this table 1 DrugBank Compound for OGFOD2 About this table Search CenterWatch for drugs/clinical trials and news about OGFOD2 / OGFD2
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Transcriptsfor OGFOD2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for OGFOD2 gene: NM_024623.1 Unigene Cluster for OGFOD2:
2-oxoglutarate and iron-dependent oxygenase domain containing 2 Hs.524817 [show with all ESTs ] Unigene Representative Sequence: BC071172 18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25 ): ENST00000397389 (uc001udv.1 uc001udt.1 uc001udu.1 uc001udw.1 uc001udy.1 uc001udz.1 )ENST00000536615 ENST00000538755 ENST00000536150 (uc001uds.1 ) ENST00000406539 (uc009zxs.1 )ENST00000545056 ENST00000545612 ENST00000538628 ENST00000542117 ENST00000545317 ENST00000535970 ENST00000544358 ENST00000544852 ENST00000454694 ENST00000228922 (uc001uea.1 )ENST00000537966 ENST00000545396 ENST00000420319 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OGFOD2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OGFOD2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: OGFOD2 (NM_024623 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OGFOD2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OGFOD2
Additional cDNA sequence: AK023553.1 AK094820.1 AK095481.1 AK303095.1 BC009181.1 BC015605.2 BC033857.1 BC047676.1 BC071172.1 BC098119.1 BC098293.1 BC101940.1 BC105637.1 BX640675.1 BX640734.1 CR457316.1
24/25 DOTS entries (see all 25 ): DT.311841 DT.101984831
DT.311842 DT.101983596 DT.121179283 DT.102835395 DT.101983595 DT.95177500 DT.91742581 DT.100667619 DT.95211042 DT.100648932 DT.99967424 DT.100755256 DT.100755255 DT.91742584 DT.97860696 DT.100648934 DT.102835393 DT.91742587 DT.97823542 DT.100018699 DT.100667620 DT.97784209 1 AceView cDNA sequence :
NM_024623 GeneLoc Exon Structure 5/16 Alternative Splicing Database (ASD) splice patterns (SP) for OGFOD2 (see all 16 ) About this scheme ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · SP1 :       -   -   -     -           -   -   -       -   -   -               SP2 :                       -   -   -   -   -   -   -   -     -             SP3 :       -   -   -     -           -   -   -   -   -   -   -   -   -             SP4 :               -           -   -   -   -   -   -   -   -   -             SP5 :       -   -   -     -           -   -   -   -   -   -   -   -   -   -          
ExUns: 9c · 9d · 9e ^ 10a · 10b · 10c SP1 :             SP2 :             SP3 :             SP4 :             SP5 :            
ECgene alternative splicing isoforms for OGFOD2
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Expression for OGFOD2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section OGFOD2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGCTGCCGTG
About this image See OGFOD2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OGFOD2 SOURCE GeneReport for Unigene cluster: Hs.524817 SABiosciences Custom PCR Arrays for OGFOD2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for OGFOD2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat OGFOD2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat OGFOD2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat OGFOD2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGFOD2
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Orthologsfor OGFOD2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for OGFOD2 gene from 7/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for OGFOD2 (if available)TreeFam Gene Tree for OGFOD2 (if available)
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Paralogsfor OGFOD2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor OGFOD2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for OGFOD2 (123459127 - 123464590 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for OGFOD2 3 CNVs : 48972 4790 48973
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing OGFOD2
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Disorders
/ Diseasesfor OGFOD2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor OGFOD2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for OGFOD2 gene integrated from 9 sources : (articles sorted by number of sources associating them with OGFOD2) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922) 1 Ramsuran V....Ndung'u T. (2011) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423) 7 Imming P....Meyer A. (2006) How many drug targets are there? (PubMed id 17139284) 7 Overington J.P....Hopkins A.L. (2006) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004)
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External Searches for OGFOD2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing OGFOD2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing OGFOD2 gene
(According to HUGE )
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Specialized Databases showing OGFOD2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for OGFOD2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for OGFOD2 gene: Search GeneIP for patents involving OGFOD2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor OGFOD2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for OGFOD2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for OGFOD2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for OGFOD2 OriGene Protein Over-expression Lysate for OGFOD2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for OGFOD2 OriGene 3'-UTR Clone for OGFOD2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OGFOD2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OGFOD2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for OGFOD2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for OGFOD2 OriGene Custom Protein Services for OGFOD2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OGFOD2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing OGFOD2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat OGFOD2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat OGFOD2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat OGFOD2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat OGFOD2
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OGFOD2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGFOD2
ThermoFisher Antibodies for OGFOD2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OGFOD2
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Aliases for OGFOD2
Databases for OGFOD2
Disorders / Diseases for OGFOD2
Domains / Families for OGFOD2
Drugs / Compounds for OGFOD2
Expression for OGFOD2
Function for OGFOD2
Genomic Views for OGFOD2
Intellectual Property for OGFOD2
Orthologs for OGFOD2
Paralogs for OGFOD2
Pathways / Interactions for OGFOD2
Products for OGFOD2
Proteins for OGFOD2
Publications for OGFOD2
Search Box for OGFOD2
Summaries for OGFOD2
Transcripts for OGFOD2
Variants for OGFOD2
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