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Aliases for OGFOD1 Gene

Aliases for OGFOD1 Gene

  • 2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 1 2 3
  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 1 2 3 5
  • TPA1 2 3 4
  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain-Containing Protein 1 3 4
  • Termination And Polyadenylation 1 Homolog 3 4
  • TPA1, Termination And Polyadenylation 1, Homolog 3
  • Termination And Polyadenylation 1 2
  • Homolog (S. Cerevisiae) 2
  • EC 1.14.11.- 4
  • EC 1.14.11 63
  • KIAA1612 4

External Ids for OGFOD1 Gene

Previous GeneCards Identifiers for OGFOD1 Gene

  • GC16P055043
  • GC16P042355

Summaries for OGFOD1 Gene

GeneCards Summary for OGFOD1 Gene

OGFOD1 (2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

UniProtKB/Swiss-Prot for OGFOD1 Gene

  • Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of Pro-62 of small ribosomal subunit RPS23, thereby regulating protein translation termination efficiency. Involved in stress granule formation.

Gene Wiki entry for OGFOD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFOD1 Gene

Genomics for OGFOD1 Gene

Regulatory Elements for OGFOD1 Gene

Enhancers for OGFOD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OGFOD1 on UCSC Golden Path with GeneCards custom track

Promoters for OGFOD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OGFOD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OGFOD1 Gene

Chromosome:
16
Start:
56,451,417 bp from pter
End:
56,479,100 bp from pter
Size:
27,684 bases
Orientation:
Plus strand

Genomic View for OGFOD1 Gene

Genes around OGFOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGFOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGFOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFOD1 Gene

Proteins for OGFOD1 Gene

  • Protein details for OGFOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N543-OGFD1_HUMAN
    Recommended name:
    Prolyl 3-hydroxylase OGFOD1
    Protein Accession:
    Q8N543
    Secondary Accessions:
    • H3BUQ2
    • Q9H7U5
    • Q9H9J9
    • Q9HA87
    • Q9HCG0
    • Q9NVB6

    Protein attributes for OGFOD1 Gene

    Size:
    542 amino acids
    Molecular mass:
    63246 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Cofactor:
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13438.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14880.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OGFOD1 Gene

    Alternative splice isoforms for OGFOD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGFOD1 Gene

Proteomics data for OGFOD1 Gene at MOPED

Post-translational modifications for OGFOD1 Gene

  • Ubiquitination at Lys 117
  • Modification sites at PhosphoSitePlus

Other Protein References for OGFOD1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OGFOD1

Domains & Families for OGFOD1 Gene

Protein Domains for OGFOD1 Gene

Suggested Antigen Peptide Sequences for OGFOD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N543

UniProtKB/Swiss-Prot:

OGFD1_HUMAN :
  • Contains 1 Fe2OG dioxygenase domain.
  • Belongs to the TPA1 family.
Domain:
  • Contains 1 Fe2OG dioxygenase domain.
Family:
  • Belongs to the TPA1 family.
genes like me logo Genes that share domains with OGFOD1: view

No data available for Gene Families for OGFOD1 Gene

Function for OGFOD1 Gene

Molecular function for OGFOD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2.
UniProtKB/Swiss-Prot Function:
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of Pro-62 of small ribosomal subunit RPS23, thereby regulating protein translation termination efficiency. Involved in stress granule formation.

Enzyme Numbers (IUBMB) for OGFOD1 Gene

Gene Ontology (GO) - Molecular Function for OGFOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0031418 L-ascorbic acid binding IEA --
GO:0031543 peptidyl-proline dioxygenase activity IDA 24550447
genes like me logo Genes that share ontologies with OGFOD1: view
genes like me logo Genes that share phenotypes with OGFOD1: view

Animal Models for OGFOD1 Gene

MGI Knock Outs for OGFOD1:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OGFOD1 Gene

Localization for OGFOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGFOD1 Gene

Isoform 1: Cytoplasm. Nucleus. Note=Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OGFOD1 Gene COMPARTMENTS Subcellular localization image for OGFOD1 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for OGFOD1 Gene

Pathways & Interactions for OGFOD1 Gene

SuperPathways for OGFOD1 Gene

No Data Available

Interacting Proteins for OGFOD1 Gene

Gene Ontology (GO) - Biological Process for OGFOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation IMP 24550447
GO:0018126 protein hydroxylation IDA 24550447
GO:0019511 peptidyl-proline hydroxylation IDA 24550447
GO:0034063 stress granule assembly IMP 24550447
genes like me logo Genes that share ontologies with OGFOD1: view

No data available for Pathways by source and SIGNOR curated interactions for OGFOD1 Gene

Drugs & Compounds for OGFOD1 Gene

(1) Drugs for OGFOD1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin C Approved Nutra Target 471,471

(1) Additional Compounds for OGFOD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with OGFOD1: view

Transcripts for OGFOD1 Gene

Unigene Clusters for OGFOD1 Gene

2-oxoglutarate and iron-dependent oxygenase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OGFOD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for OGFOD1 Gene

GeneLoc Exon Structure for
OGFOD1
ECgene alternative splicing isoforms for
OGFOD1

Expression for OGFOD1 Gene

mRNA expression in normal human tissues for OGFOD1 Gene

mRNA differential expression in normal tissues according to GTEx for OGFOD1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for OGFOD1 Gene

This gene is overexpressed in Cervix (47.2), Breast (10.0), and Plasma (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OGFOD1 Gene



SOURCE GeneReport for Unigene cluster for OGFOD1 Gene Hs.231883

genes like me logo Genes that share expression patterns with OGFOD1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OGFOD1 Gene

Orthologs for OGFOD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OGFOD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OGFOD1 35
  • 87.07 (n)
  • 88.13 (a)
OGFOD1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OGFOD1 35
  • 90.1 (n)
  • 89.11 (a)
OGFOD1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ogfod1 35
  • 84.01 (n)
  • 83.21 (a)
Ogfod1 16
Ogfod1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OGFOD1 35
  • 99.14 (n)
  • 98.34 (a)
OGFOD1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ogfod1 35
  • 83.64 (n)
  • 83.21 (a)
oppossum
(Monodelphis domestica)
Mammalia OGFOD1 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGFOD1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves OGFOD1 35
  • 67.63 (n)
  • 65.23 (a)
OGFOD1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGFOD1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ogfod1 35
  • 61.73 (n)
  • 60.28 (a)
Str.13349 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4465 35
zebrafish
(Danio rerio)
Actinopterygii ogfod1 35
  • 59.99 (n)
  • 57.62 (a)
wufc33b08 35
ogfod1 36
  • 51 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3158 35
worm
(Caenorhabditis elegans)
Secernentea C17G10.1 35
  • 44.78 (n)
  • 34.35 (a)
C17G10.1 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPA1 36
  • 20 (a)
OneToOne
TPA1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for OGFOD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OGFOD1 Gene

ENSEMBL:
Gene Tree for OGFOD1 (if available)
TreeFam:
Gene Tree for OGFOD1 (if available)

Paralogs for OGFOD1 Gene

Pseudogenes.org Pseudogenes for OGFOD1 Gene

genes like me logo Genes that share paralogs with OGFOD1: view

No data available for Paralogs for OGFOD1 Gene

Variants for OGFOD1 Gene

Sequence variations from dbSNP and Humsavar for OGFOD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs34883368 - 56,466,220(+) TTCCT(C/T)CCTGG reference, missense
rs4419055 -- 56,457,345(+) tttat(A/G)tgtaa intron-variant
rs4429293 -- 56,459,264(+) gaacc(A/G)gggag intron-variant
rs13331622 -- 56,457,459(+) ctgaa(A/G)ttagg intron-variant
rs4784670 -- 56,464,599(+) tgctg(G/T)ttgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OGFOD1 Gene

Variant ID Type Subtype PubMed ID
nsv833243 CNV Gain 17160897

Variation tolerance for OGFOD1 Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OGFOD1 Gene

HapMap Linkage Disequilibrium report
OGFOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFOD1 Gene

Disorders for OGFOD1 Gene

Relevant External Links for OGFOD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OGFOD1

No disorders were found for OGFOD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OGFOD1 Gene

Publications for OGFOD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for OGFOD1 Gene

Sources for OGFOD1 Gene

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