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Aliases for OGFOD1 Gene

Aliases for OGFOD1 Gene

  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 1 2 3
  • TPA1 2 3 4
  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain-Containing Protein 1 3 4
  • Termination And Polyadenylation 1 Homolog 3 4
  • TPA1, Termination And Polyadenylation 1, Homolog 3
  • Termination And Polyadenylation 1 2
  • Prolyl 3-Hydroxylase OGFOD1 3
  • Homolog (S. Cerevisiae) 2
  • EC 1.14.11.- 4
  • EC 1.14.11 63
  • KIAA1612 4

External Ids for OGFOD1 Gene

Previous GeneCards Identifiers for OGFOD1 Gene

  • GC16P055043
  • GC16P042355

Summaries for OGFOD1 Gene

GeneCards Summary for OGFOD1 Gene

OGFOD1 (2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

UniProtKB/Swiss-Prot for OGFOD1 Gene

  • Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of Pro-62 of small ribosomal subunit RPS23, thereby regulating protein translation termination efficiency. Involved in stress granule formation.

Gene Wiki entry for OGFOD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFOD1 Gene

Genomics for OGFOD1 Gene

Genomic Location for OGFOD1 Gene

Start:
56,451,490 bp from pter
End:
56,479,100 bp from pter
Size:
27,611 bases
Orientation:
Plus strand

Genomic View for OGFOD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OGFOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFOD1 Gene

Proteins for OGFOD1 Gene

  • Protein details for OGFOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N543-OGFD1_HUMAN
    Recommended name:
    Prolyl 3-hydroxylase OGFOD1
    Protein Accession:
    Q8N543
    Secondary Accessions:
    • H3BUQ2
    • Q9H7U5
    • Q9H9J9
    • Q9HA87
    • Q9HCG0
    • Q9NVB6

    Protein attributes for OGFOD1 Gene

    Size:
    542 amino acids
    Molecular mass:
    63246 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Cofactor:
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13438.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14880.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OGFOD1 Gene

    Alternative splice isoforms for OGFOD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGFOD1 Gene

Proteomics data for OGFOD1 Gene at MOPED

Post-translational modifications for OGFOD1 Gene

  • Ubiquitination at Lys117
  • Modification sites at PhosphoSitePlus

Other Protein References for OGFOD1 Gene

Domains for OGFOD1 Gene

Protein Domains for OGFOD1 Gene

Suggested Antigen Peptide Sequences for OGFOD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N543

UniProtKB/Swiss-Prot:

OGFD1_HUMAN :
  • Q8N543
Domain:
  • Contains 1 Fe2OG dioxygenase domain.
Family:
  • Belongs to the TPA1 family.
genes like me logo Genes that share domains with OGFOD1: view

No data available for Gene Families for OGFOD1 Gene

Function for OGFOD1 Gene

Molecular function for OGFOD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2.
UniProtKB/Swiss-Prot Function: Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of Pro-62 of small ribosomal subunit RPS23, thereby regulating protein translation termination efficiency. Involved in stress granule formation.

Enzyme Numbers (IUBMB) for OGFOD1 Gene

Gene Ontology (GO) - Molecular Function for OGFOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors --
GO:0031418 L-ascorbic acid binding IEA --
GO:0031543 peptidyl-proline dioxygenase activity IDA 24550447
genes like me logo Genes that share ontologies with OGFOD1: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OGFOD1 Gene

Localization for OGFOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGFOD1 Gene

Isoform 1: Cytoplasm. Nucleus. Note=Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OGFOD1 Gene COMPARTMENTS Subcellular localization image for OGFOD1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for OGFOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0010494 cytoplasmic stress granule IMP 24550447
genes like me logo Genes that share ontologies with OGFOD1: view

Pathways for OGFOD1 Gene

SuperPathways for OGFOD1 Gene

No Data Available

Interacting Proteins for OGFOD1 Gene

Gene Ontology (GO) - Biological Process for OGFOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006449 regulation of translational termination IMP 24550447
GO:0008283 cell proliferation IMP 24550447
GO:0018126 protein hydroxylation IDA 24550447
GO:0019511 peptidyl-proline hydroxylation IDA 24550447
GO:0034063 stress granule assembly IMP 24550447
genes like me logo Genes that share ontologies with OGFOD1: view

No data available for Pathways by source for OGFOD1 Gene

Compounds for OGFOD1 Gene

(2) HMDB Compounds for OGFOD1 Gene

Compound Synonyms Cas Number PubMed IDs
Ascorbic acid
  • (+)-ascorbate
50-81-7
Iron
  • Armco iron
7439-89-6

(1) Drugbank Compounds for OGFOD1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin C
  • Ascorbate
50-81-7 target
genes like me logo Genes that share compounds with OGFOD1: view

Transcripts for OGFOD1 Gene

Unigene Clusters for OGFOD1 Gene

2-oxoglutarate and iron-dependent oxygenase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OGFOD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for OGFOD1 Gene

GeneLoc Exon Structure for
OGFOD1
ECgene alternative splicing isoforms for
OGFOD1

Expression for OGFOD1 Gene

mRNA expression in normal human tissues for OGFOD1 Gene

mRNA differential expression in normal tissues according to GTEx for OGFOD1 Gene

This gene is overexpressed in Muscle - Skeletal (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OGFOD1 Gene

SOURCE GeneReport for Unigene cluster for OGFOD1 Gene Hs.231883

genes like me logo Genes that share expressions with OGFOD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OGFOD1 Gene

Orthologs for OGFOD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OGFOD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGFOD1 35
  • 99.14 (n)
  • 98.34 (a)
OGFOD1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OGFOD1 35
  • 87.07 (n)
  • 88.13 (a)
OGFOD1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OGFOD1 35
  • 90.1 (n)
  • 89.11 (a)
OGFOD1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ogfod1 35
  • 84.01 (n)
  • 83.21 (a)
Ogfod1 16
Ogfod1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OGFOD1 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGFOD1 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ogfod1 35
  • 83.64 (n)
  • 83.21 (a)
chicken
(Gallus gallus)
Aves OGFOD1 35
  • 67.63 (n)
  • 65.23 (a)
OGFOD1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGFOD1 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4465 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ogfod1 35
  • 61.73 (n)
  • 60.28 (a)
Str.13349 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3158 35
zebrafish
(Danio rerio)
Actinopterygii ogfod1 35
  • 59.99 (n)
  • 57.62 (a)
ogfod1 36
  • 51 (a)
OneToOne
wufc33b08 35
worm
(Caenorhabditis elegans)
Secernentea C17G10.1 35
  • 44.78 (n)
  • 34.35 (a)
C17G10.1 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPA1 36
  • 20 (a)
OneToOne
TPA1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for OGFOD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OGFOD1 Gene

ENSEMBL:
Gene Tree for OGFOD1 (if available)
TreeFam:
Gene Tree for OGFOD1 (if available)

Paralogs for OGFOD1 Gene

Pseudogenes.org Pseudogenes for OGFOD1 Gene

genes like me logo Genes that share paralogs with OGFOD1: view

No data available for Paralogs for OGFOD1 Gene

Variants for OGFOD1 Gene

Sequence variations from dbSNP and Humsavar for OGFOD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2288055 -- 56,467,894(+) GCTGC(C/T)TCTTC intron-variant
rs4419055 -- 56,457,345(+) tttat(A/G)tgtaa intron-variant
rs4427793 -- 56,464,246(+) actgt(A/C)tcagg intron-variant
rs4429293 -- 56,459,264(+) gaacc(A/G)gggag intron-variant
rs4784670 -- 56,464,599(+) tgctg(G/T)ttgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OGFOD1 Gene

Variant ID Type Subtype PubMed ID
nsv833243 CNV Gain 17160897

Relevant External Links for OGFOD1 Gene

HapMap Linkage Disequilibrium report
OGFOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFOD1 Gene

Disorders for OGFOD1 Gene

No disorders were found for OGFOD1 Gene.

No data available for UniProtKB/Swiss-Prot for OGFOD1 Gene

Publications for OGFOD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress. (PMID: 20154146) Wehner K.A. … Sarnow P. (Mol. Cell. Biol. 2010) 3 4
  4. OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling. (PMID: 20579638) Saito K. … Matsushita M. (FEBS Lett. 2010) 3 4
  5. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. (PMID: 24550447) Singleton R.S. … Cockman M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 4

Products for OGFOD1 Gene

Sources for OGFOD1 Gene

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