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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OGFOD1 Gene

protein-coding   GIFtS: 48
GCID: GC16P056488

2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing...

  Search for OGFOD1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 11 2     2-Oxoglutarate And Iron-Dependent Oxygenase Domain-Containing Protein 12
TPA11 2 3     TPA1, Termination And Polyadenylation 1, Homolog2
Termination And Polyadenylation 1 Homolog2 3     EC 1.14.11.-3
Homolog (S. Cerevisiae)1     KIAA16123
Termination And Polyadenylation 11     EC 1.14.118

External Ids:    HGNC: 255851   Entrez Gene: 552392   Ensembl: ENSG000000872637   UniProtKB: Q8N5433   

Export aliases for OGFOD1 gene to outside databases

Previous GC identifers: GC16P055043 GC16P042355


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OGFOD1 Gene: 
OGFOD1 (2-oxoglutarate and iron-dependent oxygenase domain containing 1) is a protein-coding gene. GO annotations related to this gene include L-ascorbic acid binding and iron ion binding.

Gene Wiki entry for OGFOD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OGFOD1 gene promoter:
         AP-2alpha isoform 3   AML1a   AP-2alpha isoform 2   STAT5A   E47   GATA-1   AREB6   GATA-6   AP-2alpha isoform 4   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOGFOD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OGFOD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OGFOD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

OGFOD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OGFOD1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056488:  view genomic region     (about GC identifiers)

Start:
56,485,402 bp from pter      End:
56,513,012 bp from pter
Size:
27,611 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OGFD1_HUMAN, Q8N543 (See protein sequence)
Recommended Name: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1  
Size: 542 amino acids; 63246 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Cofactor: Ascorbate (By similarity)
Subcellular location: Isoform 1: Cytoplasm. Nucleus
Subcellular location: Isoform 2: Cytoplasm
Sequence caution: Sequence=BAB13438.1; Type=Erroneous initiation; Sequence=BAB14880.1; Type=Erroneous initiation;
Secondary accessions: Q9H7U5 Q9H9J9 Q9HA87 Q9HCG0 Q9NVB6
Alternative splicing: 2 isoforms:  Q8N543-1   Q8N543-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OGFOD1: NX_Q8N543

Explore proteomics data for OGFOD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N543

  • 4/9 DME Specific Peptides for OGFOD1 (Q8N543) (see all 9)
     QIQEEFEE  SRLSISGWF  EYGGFTSYIAK  PHIPQDHEILY 

    OGFOD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OGFOD1 Protein Expression
    REFSEQ proteins: NP_060703.3  
    ENSEMBL proteins: 
     ENSP00000457258   ENSP00000455149   ENSP00000456111   ENSP00000457553   ENSP00000456016  
     ENSP00000337196   ENSP00000457746  

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    OGFOD1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR019601 Oxoglutarate/Fe-dep_Oase_C
     IPR006620 Pro_4_hyd_alph
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q8N543

    ProtoNet protein and cluster: Q8N543

    UniProtKB/Swiss-Prot: OGFD1_HUMAN, Q8N543
    Similarity: Belongs to the TPA1 family
    Similarity: Contains 1 Fe2OG dioxygenase domain


    OGFOD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA--
    GO:0031418L-ascorbic acid binding IEA--
         
    OGFOD1 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidOGFOD1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OGFOD1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for OGFOD1 (Q8N5433 ENSP000003371964) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGO2Q9UKV83I2D: score=4 
    COG1Q8WTW33I2D: score=4 
    HSPA8P111423I2D: score=4 
    UBCENSP000003448184STRING: ENSP00000344818
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    OGFOD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OGFOD1 (OGFD1)

    2 HMDB Compounds for OGFOD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ascorbic acid(+)-ascorbate (see all 140)50-81-7--
    IronArmco iron (see all 19)7439-89-6--

    1 DrugBank Compound for OGFOD1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin CAscorbate (see all 6)50-81-7target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about OGFOD1 / OGFD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OGFOD1 gene: 
    NM_018233.3  

    Unigene Cluster for OGFOD1:

    2-oxoglutarate and iron-dependent oxygenase domain containing 1
    Hs.231883  [show with all ESTs]
    Unigene Representative Sequence: NM_018233
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566157(uc002ejb.3 uc002ejc.3) ENST00000569802 ENST00000562150
    ENST00000561646 ENST00000565682 ENST00000336111 ENST00000563733 ENST00000568172
    ENST00000569645 ENST00000568397 ENST00000565209
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate OGFOD1:
    hsa-miR-4261 hsa-miR-3688-3p hsa-miR-3658 hsa-miR-1224-5p hsa-miR-3714 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidOGFOD1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK001688.1 AK022130.1 AK022752.1 AK024314.1 AK304584.1 BC032919.1 

    16 DOTS entries:

    DT.100827819  DT.409937  DT.100827810  DT.101957248  DT.100827814  DT.95100255  DT.40286882  DT.92445989 
    DT.92445990  DT.100827821  DT.120658066  DT.91656989  DT.92046014  DT.120658043  DT.120658136  DT.99974119 

    24/212 AceView cDNA sequences (see all 212):

    BQ643178 AI817242 AU134133 AL711389 CR615197 BQ430151 BE645875 BM827760 
    CB305602 BM706187 BX327322 AI754257 AL708454 BM996096 BQ424365 AA007182 
    CB113222 AI754149 BQ774341 BM470550 AW015152 AJ709422 AL708319 CA427497 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for OGFOD1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                            -                                                                     
    SP2:                                -           -                                                                     
    SP3:                                            -                                                                     
    SP4:                                            -     -                                                               
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for OGFOD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OGFOD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OGFOD1 Expression
    About this image


    See OGFOD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OGFOD1

    SOURCE GeneReport for Unigene cluster: Hs.231883
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for OGFOD1 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ogfod11 , 5 2-oxoglutarate and iron-dependent oxygenase domain more1, 5 84.01(n)1
    83.21(a)1
      8 (46.08 cM)5
    2700861  NM_177767.41  NP_808435.31 
     940371985 
    chicken
    (Gallus gallus)
    Aves OGFOD11 2-oxoglutarate and iron-dependent oxygenase domain more 69.41(n)
    68.49(a)
      415695  XM_414062.3  XP_414062.3 
    lizard
    (Anolis carolinensis)
    Reptilia OGFOD16
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343675.1(103865-119911)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.44652 Xenopus laevis transcribed sequence with weak similarity more 73.9(n)    48027595 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc33b082 wufc33b08 72.38(n)   324573  BC055624.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0029341 AGAP002934-PA 45.83(n)
    36.75(a)
      4577264  XM_001237408.2  XP_001237409.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C17G10.11 Protein C17G10.1 44.6(n)
    34.07(a)
      173947  NM_062687.4  NP_495088.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPA1(YER049W)4 Poly(rA)-binding protein involved in translation termination more   --   5(251728-253662) 856775  NP_010969.1 


    ENSEMBL Gene Tree for OGFOD1 (if available)
    TreeFam Gene Tree for OGFOD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OGFOD1 gene

    OGFOD1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OGFOD1
    PGOHUM00000248397


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/525 SNPs in OGFOD1 are shown (see all 525)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80561711,2
    C,F,A,H--56487445(+) ACATTC/GTTAAG 1 -- int126Minor allele frequency- G:0.40NS EA NA WA CSA 2567
    rs1870915901,2
    --56487623(+) AGAGAA/GTGATA 1 -- int10--------
    rs1402322721,2
    --56487648(+) TACACA/CGGTTT 1 -- int10--------
    rs759420791,2
    F--56487704(+) TCTGAC/TACTTA 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1915427731,2
    --56487796(+) TTCCAA/GTTGCT 1 -- int10--------
    rs1451910611,2
    --56487815(+) AAGTAA/GTAATA 1 -- int10--------
    rs1479836891,2
    C--56487927(+) GATGAG/TGAAGA 1 -- int10--------
    rs1843789491,2
    --56488182(+) TTGAAC/TCCAGG 1 -- int10--------
    rs1163535881,2
    C,F--56488246(+) CAAGAG/ACAAAA 1 -- int11Minor allele frequency- A:0.10WA 118
    rs1121049951,2
    C--56488360(+) CGTTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for OGFOD1 (56485402 - 56513012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OGFOD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833243CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OGFOD1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with OGFOD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    5. Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization. (PubMed id 22002106)2 Ahmad Y.... Lamond A.I. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55239 HGNC: 25585 AceView: FLJ10826 Ensembl:ENSG00000087263 euGenes: HUgn55239
    ECgene: OGFOD1 H-InvDB: OGFOD1

    (According to HUGE)
    About This Section
    HUGE: KIAA1612

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OGFOD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OGFOD1 gene:
    Search GeneIP for patents involving OGFOD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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