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OGDHL Gene

protein-coding   GIFtS: 50

GC10M050612
oxoglutarate dehydrogenase-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 1.2.4.- 3
FLJ10851 1
KIAA1290 3
OTTHUMP00000019588 2
Descriptions
Alpha-ketoglutarate dehydrogenase-like 3
oxoglutarate dehydrogenase-like 2
External Ids
HGNC: 255901
Entrez Gene: 557532
UniProtKB: Q9ULD03
Ensembl: ENSG000001974447
Search outside databases for aliases for OGDHL gene

Previous GC identifer: GC10M050288

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OGDHL gene  

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC chromosome: 10

OGDHL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M050612:     (about GC identifiers)

Start:
50,612,717 bp from pter
End:
50,640,375 bp from pter
Size:
27,659 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_017696.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OGDHL_HUMAN, Q9ULD0 (See protein sequence)
Recommended Name: 2-oxoglutarate dehydrogenase E1 component-like, mitochondrial precursor  
Size: 1010 amino acids; 114481 Da
Cofactor: Thiamine pyrophosphate (By similarity)
Subcellular location: Mitochondrion matrix (By similarity)
Secondary accessions: A8K2G1 Q8TAN9 Q9NVA0

REFSEQ proteins (3 alternative transcripts): 
NP_001137468.1  NP_001137469.1  NP_060715.2  


ENSEMBL proteins: 
ENSP00000363216 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005739 mitochondrion IEA--
GO:0005759 mitochondrial matrix IEA--
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Antibodies for OGDHL: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for OGDHL

Assays for OGDHL: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro domains/families:
 IPR011603 2oxoglutarate_DH_E1
 IPR005475 Transketolase_central-reg
 IPR001017 DH_E1


   GeneDecks  OGDHL for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9ULD0

ProtoNet protein and cluster: Q9ULD0

1 Blocks protein family: IPB005475 Transketolase

UniProtKB/Swiss-Prot: OGDHL_HUMAN, Q9ULD0
Similarity: Belongs to the alpha-ketoglutarate dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OGDHL)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_018245

              Applied Biosystems Silencer® siRNAs for OGDHL

              Sigma-Aldrich siRNA for OGDHL  
                     Sigma-Aldrich shRNA for OGDHL  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001143996
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001143996
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001143996 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_018245

Genatlas biochemistry entry for OGDHL:
alpha-ketoglutarate dehydrogenase,E1k subunit-like sequence

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity IEA--
GO:0016491 oxidoreductase activity IEA--
GO:0030976 thiamin pyrophosphate binding IEA--
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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for  OGDHL  (Your Favorite Gene powered by Ingenuity) 
 Tryptophan Metabolism
 Citrate Cycle
 Lysine Degradation

   GeneDecks  OGDHL for the pathways selected above  
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3 Kegg Pathways  (Kegg details for OGDHL):
 hsa00020 Citrate cycle (TCA cycle)
 hsa00310 Lysine degradation
 hsa00380 Tryptophan metabolism

   GeneDecks  OGDHL for the pathways selected above  
About GeneDecksing

5/12 Interacting proteins for OGDHL (ENSP000003632163) via UniProtKB, MINT, and/or STRING (see all 12 )
InteractantInteraction Details
GeneCardExternal ID(s)
DLSTENSP000003353043STRING (score=.991)
DLDENSP000002054023STRING (score=.983)
SUCLA2ENSP000003679233STRING (score=.912)
IDH3AENSP000002995183STRING (score=.902)
AADATENSP000003368083STRING (score=.899)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006096 glycolysis IEA--
GO:0055114 oxidation reduction IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OGDHL

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OGDHL)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_018245

              Sigma-Aldrich siRNA for OGDHL  
                     Sigma-Aldrich shRNA for OGDHL  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

REFSEQ mRNAs for OGDHL gene (3 alternative transcripts): 

NM_001143996.1   NM_001143997.1   NM_018245.2   


               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001143996
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001143996
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001143996 

Additional cDNA sequence: 

AB033116.3 AK001713.1 AK290226.1 AK296551.1 AK303729.1 AK307759.1 BC026320.1 CR603720.1 

9 DOTS entries:

DT.412735  DT.95160623  DT.100777896  DT.92452437  DT.100000713  DT.95193102  DT.102826111  DT.121290645 
DT.92452444 

24/93 AceView cDNA sequences (see all 93 ):

BF313582 BU165087 CD671366 BU787591 AW149004 BU732141 AB033116 AW664293 
CR603720 BQ613930 BX482149 CD671333 AI289176 BU070551 BX283119 BX332098 
BQ718700 AW271837 N51727 AU133174 AL523542 BM543631 BE883595 BM714440 

highest scoring ESTs for OGDHL:

AA706655 AK001713 AU133174 BC026320 BG709128 AA323896 AA341007 AA894685 AA931194 AA935762 

Unigene Cluster for OGDHL:

Oxoglutarate dehydrogenase-like
Hs.17860  [show with all ESTs]
Unigene Representative Sequence: NM_018245


GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for OGDHL (see all 17 )

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a ·
SP1:                          -     -     -           -                             -     -                                                     -               
SP2:                                                                                                                                                            
SP3:                                                                                                                                                            
SP4:              -     -     -     -     -     -     -                             -     -                                                                     
SP5:                          -     -     -     -     -                             -     -                                                                     

ExUns: 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b · 27c · 27d
SP1:                                                                    -                       -                                             
SP2:                                                  -                                                                                       
SP3:                                                                                            -                                             
SP4:                                                                                                                                          
SP5:                                                                                                                                          

About this scheme

ECgene alternative splicing isoforms for OGDHL

1 Ensembl transcript including schematic representation:
ENST00000374103  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OGDHL expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OGDHL

1 / 2 / 3

3 probe-sets matching OGDHL gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
58953_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA706655 0.80 1.00 0.91 1

219277_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018245 0.60 1.00 0.82 1

219277_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  OGDHL for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CTTCAGAGAG

SOURCE GeneReport for Unigene cluster: Hs.17860
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for OGDHL gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
OGDHL1   -- oxoglutarate dehydrogenase-like 90.39(n)
95.33(a)
477748  XM_534945.2  XP_534945.2 
cow
(Bos taurus)
OGDHL1   -- oxoglutarate dehydrogenase-like 90.03(n)
94.53(a)
531398  XM_609891.3  XP_609891.3 
rat
(Rattus norvegicus)
Ogdhl1   -- oxoglutarate dehydrogenase-like 87.82(n)
92.28(a)
290566  XM_214261.4  XP_214261.4 
mouse
(Mus musculus)
Ogdhl1, 5 145
oxoglutarate dehydrogenase-like1, 5 87.49(n)1
92.97(a)1
2390171  NM_001081130.11  NP_001074599.11 
 BC1579705  BC1579715  (see all 8)
chicken
(Gallus gallus)
OGDHL1   -- oxoglutarate dehydrogenase-like 74.44(n)
86.31(a)
423618  XM_421503.2  XP_421503.2 
About this table        Species with no ortholog for OGDHL

ENSEMBL Gene Tree for OGDHL
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for OGDHL gene
DHTKD12  OGDH2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/173 NCBI SNPs in OGDHL are shown (see all 173 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 84)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs68161,2
A,C,F,H,O50612769(+) TTTCAC/TACAGA 1 -- ut31 ese315Minor allele frequency- T:0.49MN EU EA WA NA 1330
rs137361,2
A,C,F,H,O50613074(+) GCCTAC/TAGGAC 1 -- ut31 ese312Minor allele frequency- T:0.28MN EA NA EU WA 2596
rs12582561,2
A,C,F,H50613192(-) GCCCAA/GGAGAG 1 -- ut31 ese3 trp39Minor allele frequency- G:0.27MN EU EA WA NA 2216
rs111012241,2
C,F,H50620982(+) CCACCG/ATCCGG 1 M/T mis1 ese313Minor allele frequency- A:0.18NA EU EA WA 1328
rs37507551,2
C,F,H50613254(+) ACAGCG/AAGACC 1 -- ut318Minor allele frequency- A:0.09EA NA EU WA 2056
--
rs12582551,2
A,C50612295(+) TggcgC/Tagtgg 1 -- ng510--------
rs348771951,2
C,F50621024(-) CCTCTC/GTCGCA 1 S/C mis15Minor allele frequency- G:0.01NA EU EA WA 480
rs22932391,2
F,H50617858(-) CCCCAA/GTGCCC 1 N/S mis1 ese35Minor allele frequency- G:0.01EA EU WA 1862
--
rs19858961,2
C50612425(+) TAGCCA/GGGCAT 1 -- ng510--------
--
rs178567551,2
H50623493(+) TGAGCG/AGCTGG 1 L/P mis1 ese34Minor allele frequency- A:0.00EU EA WA 398
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HapMap Linkage Disequilibrium images for OGDHL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10 PubMed articles for OGDHL gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55753 HGNC: 25590 AceView: OGDHL Ensembl:ENSG00000197444 euGenes: HUgn55753
ECgene: OGDHL H-InvDB: OGDHL
(According to HUGE)
About This Section

HUGE: KIAA1290
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OGDHL:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for OGDHL-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for OGDHL Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OGDHL Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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