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Aliases & Descriptions for OGDHL
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 1.2.4.- 3 FLJ10851 1 KIAA1290 3 OTTHUMP00000019588 2
Descriptions Alpha-ketoglutarate dehydrogenase-like 3 oxoglutarate dehydrogenase-like 2
Search outside databases for aliases for OGDHL genePrevious GC identifer: GC10M050288
Summaries for OGDHL (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Location for OGDHL
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the OGDHL gene Entrez Gene cytogenetic band: 10q11.23 Ensembl cytogenetic band: 10q11.23 HGNC chromosome: 10 OGDHL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10M050612:
(about GC identifiers )
Start:
50,612,717 bp from pter
End:
50,640,375 bp from pter
Size:
27,659 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000010.9 NT_017696.14 Proteins for OGDHL
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: OGDHL_HUMAN, Q9ULD0 (See
protein sequence )Recommended Name: 2-oxoglutarate dehydrogenase E1 component-like, mitochondrial precursor Size : 1010 amino acids; 114481 Da
Cofactor : Thiamine pyrophosphate (By similarity)
Subcellular location : Mitochondrion matrix (By similarity)
Secondary accessions : A8K2G1 Q8TAN9 Q9NVA0
REFSEQ proteins (3 alternative transcripts):
NP_001137468.1 NP_001137469.1 NP_060715.2 ENSEMBL proteins: ENSP00000363216 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005739 mitochondrion
IEA -- GO:0005759 mitochondrial matrix
IEA --
About this table Antibodies for OGDHL: Assays for OGDHL:
Protein
Domains/ Families for OGDHL(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9ULD0 ProtoNet protein and cluster: Q9ULD0
1 Blocks protein family : IPB005475 Transketolase UniProtKB/Swiss-Prot: OGDHL_HUMAN, Q9ULD0 Similarity : Belongs to the alpha-ketoglutarate dehydrogenase family
Gene Function for OGDHL
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_018245 Applied Biosystems Silencer ® siRNAs for OGDHL Sigma-Aldrich siRNA for OGDHL Sigma-Aldrich shRNA for OGDHL Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001143996                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001143996                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001143996  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018245 Genatlas biochemistry entry for OGDHL :alpha-ketoglutarate dehydrogenase,E1k subunit-like sequence 3 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
IEA -- GO:0016491 oxidoreductase activity
IEA -- GO:0030976 thiamin pyrophosphate binding
IEA --
About this table
Pathways & Interactions for OGDHL
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for OGDHL (Your Favorite Gene powered by Ingenuity) 5/12 Interacting proteins for OGDHL (ENSP00000363216 3 ) via UniProtKB, MINT, and/or STRING (see all 12
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006096 glycolysis
IEA -- GO:0055114 oxidation reduction
IEA --
About this table
Drugs & Compounds for OGDHL (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for OGDHL
Transcripts for OGDHL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_018245 Sigma-Aldrich siRNA for OGDHL Sigma-Aldrich shRNA for OGDHL Explore Sigma-Aldrich super-pooled esiRNAs
REFSEQ mRNAs for OGDHL gene (3 alternative transcripts): NM_001143996.1 NM_001143997.1 NM_018245.2
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001143996                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001143996                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001143996  
Additional cDNA sequence: AB033116.3 AK001713.1 AK290226.1 AK296551.1 AK303729.1 AK307759.1 BC026320.1 CR603720.1
9 DOTS entries : DT.412735 DT.95160623 DT.100777896 DT.92452437 DT.100000713 DT.95193102 DT.102826111 DT.121290645 DT.92452444
24/93 AceView cDNA sequences (see all 93
):BF313582 BU165087 CD671366 BU787591 AW149004 BU732141 AB033116 AW664293 CR603720 BQ613930 BX482149 CD671333 AI289176 BU070551 BX283119 BX332098 BQ718700 AW271837 N51727 AU133174 AL523542 BM543631 BE883595 BM714440
highest scoring ESTs for OGDHL :AA706655 AK001713 AU133174 BC026320 BG709128 AA323896 AA341007 AA894685 AA931194 AA935762
Unigene Cluster for OGDHL: Oxoglutarate dehydrogenase-like Hs.17860 [show with all ESTs ] Unigene Representative Sequence: NM_018245 GeneLoc Exon Structure 5/17 Alternative Splicing Database (ASD) splice patterns (SP) for OGDHL (see all 17
) ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · SP1 :         -   -   -     -           -   -                   -       SP2 :                                                     SP3 :                                                     SP4 :     -   -   -   -   -   -   -           -   -                         SP5 :         -   -   -   -   -           -   -                        
ExUns: 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b · 27c · 27d SP1 :                       -         -                 SP2 :                 -                               SP3 :                               -                 SP4 :                                               SP5 :                                              
About this scheme ECgene alternative splicing isoforms for OGDHL 1 Ensembl transcript including schematic representation : ENST00000374103
Expression for OGDHL
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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OGDHL expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for OGDHL 1 / 2 / 3
3 probe-sets matching OGDHL gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CTTCAGAGAGSOURCE GeneReport for Unigene cluster: Hs.17860
Orthologs for OGDHL
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for OGDHL gene from 5/10 species (see all 10
)
About this table Species with no ortholog for OGDHL ENSEMBL Gene Tree for OGDHL Paralogs for OGDHL (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for OGDHL gene DHTKD1 2 OGDH 2
SNPs/Variants for OGDHL (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for OGDHL (up to first 250kb)
Disorders & Mutations for OGDHL
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Medical News for OGDHL (Possibly Related Articles in
Doctor's Guide )
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Publications for OGDHL (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10 PubMed articles for OGDHL gene :
Search for OGDHL
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing OGDHL
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing OGDHL
(According to HUGE )
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Specialized Databases showing OGDHL (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for OGDHL (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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