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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OGDHL Gene

protein-coding GIFtS: 56
GCID: GC10M050942

oxoglutarate dehydrogenase-like

Explore 5 diseases affiliated with
OGDHL via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Oxoglutarate Dehydrogenase-Like¹ ²		2-Oxoglutarate Dehydrogenase-Like, Mitochondrial²
Alpha-Ketoglutarate Dehydrogenase-Like² ³		EC 1.2.4.-³
2-Oxoglutarate Dehydrogenase Complex Component E1-Like² ³		KIAA1290³
OGDC-E1-Like¹		EC 1.2.4.2⁸
FLJ10851¹

External Ids:	HGNC: 25590¹	Entrez Gene: 55753²	Ensembl: ENSG00000197444⁷	UniProtKB: Q9ULD0³

Export aliases for OGDHL gene to outside databases

Previous GC identifers: GC10M050288 GC10M050612 GC10M045207

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OGDHL gene promoter:
GATA-3 HTF NRSF form 1 Tal-1beta NRSF form 2 E47 N-Myc S8 POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OGDHL promoter sequence

Search SABiosciences Chromatin IP Primers for OGDHL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OGDHL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23 Ensembl cytogenetic band: 10q11.23 HGNC chromosome: 10

OGDHL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OGDHL gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M050942: view genomic region (about GC identifiers)

Start:	50,942,687 bp from pter	End:	50,970,425 bp from pter
Size:	27,739 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OGDHL_HUMAN, Q9ULD0 (See protein sequence)

Recommended Name: 2-oxoglutarate dehydrogenase-like, mitochondrial precursor

Size: 1010 amino acids; 114481 Da

Cofactor: Thiamine pyrophosphate (By similarity)

Subcellular location: Mitochondrion matrix (By similarity)

Sequence caution: Sequence=BAA86604.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A8K2G1 B4DKG2 B4E193 Q8TAN9 Q9NVA0

Alternative splicing: 3 isoforms: Q9ULD0-1 Q9ULD0-2 Q9ULD0-3

Explore the universe of human proteins at neXtProt for OGDHL: NX_Q9ULD0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9ULD0

4/29 DME Specific Peptides for OGDHL (Q9ULD0) (see all 29)

RLSGQDV

GQAKWVR

DLVCYRR

KSLLRHP

OGDHL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001137468.1 NP_001137469.1 NP_060715.2

ENSEMBL proteins:

ENSP00000363216 ENSP00000401356 ENSP00000390240

Human Recombinant Protein Products for OGDHL:

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	Novus Biologicals OGDHL Lysate
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for OGDHL

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005759	mitochondrial matrix	IEA	--

OGDHL for ontologies About GeneDecksing

OGDHL Antibody Products:

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	ThermoFisher Antibodies for OGDHL

Assay Products for OGDHL:

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	Uscn ELISAs and CLIAs for OGDHL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OGDHL for domains About GeneDecksing

3 InterPro domains/families:

IPR011603 2oxoglutarate_DH_E1

IPR005475 Transketolase-like_Pyr-bd

IPR001017 DH_E1

Graphical View of Domain Structure for InterPro Entry Q9ULD0

ProtoNet protein and cluster: Q9ULD0

1 Blocks protein family: IPB005475 Transketolase

UniProtKB/Swiss-Prot: OGDHL_HUMAN, Q9ULD0

Similarity: Belongs to the alpha-ketoglutarate dehydrogenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for OGDHL:

alpha-ketoglutarate dehydrogenase,E1k subunit-like sequence

Enzyme Numbers (IUBMB): EC 1.2.4.2² EC 1.2.4.-¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0030976	thiamine pyrophosphate binding	IEA	--

OGDHL for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for OGDHL:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OGDHL

miRNA Products:		OriGene 3'-UTR Clone (see all 3): OGDHL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OGDHL
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate OGDHL (see all 10):
		hsa-miR-1263 hsa-miR-4263 hsa-miR-139-5p hsa-miR-138-1* hsa-miR-9 hsa-miR-659 hsa-miR-3622b-3p hsa-miR-377

		SwitchGear 3'UTR luciferase reporter plasmid: OGDHL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OGDHL (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OGDHL (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGDHL

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lysine degradation

Lysine degradation

1.00

TCA cycle II (eukaryotic)

TCA cycle II (eukaryotic)

1.00

TCA Cycle

Citrate cycle (TCA cycle)

0.65

Tryptophan metabolism

Tryptophan metabolism

0.47

Metabolism

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for OGDHL

TCA cycle II (eukaryotic)

4 Kegg Pathways (Kegg details for OGDHL):

	Citrate cycle (TCA cycle)
	Lysine degradation
	Tryptophan metabolism
	Metabolic pathways

OGDHL for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OGDHL

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/31 Interacting proteins for OGDHL (Q9ULD0¹ ENSP00000363216⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STAT3	P40763¹, ENSP00000264657⁴	EBI-3940481,EBI-518675 STRING: ENSP00000264657
AADAT	ENSP00000226840⁴	STRING: ENSP00000226840
IDH1	ENSP00000260985⁴	STRING: ENSP00000260985
IDH2	ENSP00000331897⁴	STRING: ENSP00000331897
IDH3B	ENSP00000370223⁴	STRING: ENSP00000370223

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006096	glycolysis	IEA	--
GO:0006099	tricarboxylic acid cycle	IEA	--

OGDHL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OGDHL

10/12 HMDB Compounds for OGDHL (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Ketobutyric acid	2-Ketobutanoate (see all 35)	600-18-0	--
3-carboxy-1-hydroxypropylthiamine diphosphate	3-Carboxy-1-hydroxypropyl-ThPP (see all 3)	--	--
Carbon dioxide	Carbon oxide (see all 5)	124-38-9	--
Coenzyme A	Acetoacetyl coenzyme A sodium salt (see all 21)	85-61-0	--
Glutaryl-CoA	glutaryl-CoA (see all 2)	103192-48-9	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
Oxoadipic acid	alpha-ketoadipic acid (see all 19)	3184-35-8	--
Oxoglutaric acid	2-Ketoglutarate (see all 9)	328-50-7	--
S-Glutaryldihydrolipoamide		--	--

Search CenterWatch for drugs/clinical trials and news about OGDHL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OGDHL gene (3 alternative transcripts):

NM_001143996.1 NM_001143997.1 NM_018245.2

Unigene Cluster for OGDHL:

Oxoglutarate dehydrogenase-like

Hs.17860 [show with all ESTs]

Unigene Representative Sequence: NM_018245

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374103(uc009xog.3 uc001jie.3 uc009xoh.2) ENST00000490844

ENST00000496884 ENST00000471460 ENST00000419399(uc010qgt.2) ENST00000432695(uc010qgu.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): OGDHL Browse OriGene MicroRNA Expression Plasmids
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		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate OGDHL (see all 10):
		hsa-miR-1263 hsa-miR-4263 hsa-miR-139-5p hsa-miR-138-1* hsa-miR-9 hsa-miR-659 hsa-miR-3622b-3p hsa-miR-377

		SwitchGear 3'UTR luciferase reporter plasmid: OGDHL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against OGDHL

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OGDHL

Additional cDNA sequence:

AB033116.3 AK001713.1 AK290226.1 AK296551.1 AK303729.1 AK307759.1 BC026320.1

9 DOTS entries:

DT.412735 DT.95160623 DT.100777896 DT.100000713 DT.92452437 DT.95193102 DT.121290645 DT.92452444

DT.102826111

24/93 AceView cDNA sequences (see all 93):

BX482149 BU165087 AW664293 CR603720 BF313582 AB033116 BU732141 CD671366

CD671333 BU787591 AW149004 BQ613930 AI289176 AA948651 AU133174 BX283119

AI215507 AI218254 N51727 BM504223 BU741802 CD629111 BX333646 AU159536

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for OGDHL (see all 17) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	^	7	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·
SP1:									-		-		-				-										-		-																		-
SP2:
SP3:
SP4:					-		-		-		-		-		-		-										-		-
SP5:									-		-		-		-		-										-		-

ExUns:	13b	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20a	·	20b	^	21	^	22a	·	22b	^	23	^	24	^	25a	·	25b	·	25c	^	26	^	27a	·	27b	·	27c	·	27d
SP1:																							-								-
SP2:																	-
SP3:																															-
SP4:
SP5:

ECgene alternative splicing isoforms for OGDHL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OGDHL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTCAGAGAG

About this image

OGDHL expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Human kidney epithelial cell spheroids (Kidney spheroids for...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See OGDHL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OGDHL

SOURCE GeneReport for Unigene cluster: Hs.17860

SABiosciences Expression via Pathway-Focused PCR Arrays including OGDHL:

Amino Acid Metabolism II in human mouse rat

Amino Acid Metabolism I in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Glucose Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OGDHL Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OGDHL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OGDHL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGDHL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for OGDHL gene from 9/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ogdhl^{1 , 5}	oxoglutarate dehydrogenase-like^{1, 5}	87.62(n)¹ 93.17(a)¹		14 (19.40 cM)⁵ 239017¹ NM_001081130.1¹ NP_001074599.1¹ 32322019⁵
chicken (Gallus gallus)	Aves	OGDHL¹	oxoglutarate dehydrogenase-like	74.54(n) 86.51(a)		423618 NM_001199544.1 NP_001186473.1
lizard (Anolis carolinensis)	Reptilia	OGDHL⁶	--	83(a)	1 ↔ 1	GL343199.1(3628323-3680445)
zebrafish (Danio rerio)	Actinopterygii	ogdhl¹	oxoglutarate dehydrogenase-like	73.12(n) 81.15(a)		559207 XM_682523.3 XP_687615.2
fruit fly (Drosophila melanogaster)	Insecta	Nc73EF⁶ CG33791⁶	--	56(a) 41(a)	many → 1 possible ortholog	3L(16948035-16961824) 3L(1602954-1617355)
worm (Caenorhabditis elegans)	Secernentea	ogdh-1⁶	2-oxoglutarate dehydrogenase, mitochondrial	54(a)	possible ortholog	IV(4696827-4704005)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G55410⁶ AT5G65750⁶	2-oxoglutarate dehydrogenase, E1 component	47(a) 46(a)	many ↔ many many ↔ many	3(20541435-20546034) 5(26303693-26308189)
rice (Oryza sativa)	Liliopsida	Os.13926²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	74.5(n)		AK100482.1
E. coli (Escherichia coli)	Gamma proteobacteria	sucA⁶	2-oxoglutarate decarboxylase, thiamin-requiring	41(a)	1 → many	Chromosome(757929-760730)

ENSEMBL Gene Tree for OGDHL (if available)
TreeFam Gene Tree for OGDHL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OGDHL gene

DHTKD1² OGDH²

2 SIMAP similar genes for OGDHL using alignment to 1 protein entry: OGDHL_HUMAN:

OGDH DHTKD1

OGDHL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11362651^1,2	C	--	45232274(+)	`AAGAG-/CCCTCT`	1	--	int¹		1		NA	2
rs111401768^1,2		--	50942206(+)	`CAGTAC/TCTCCA`	3	--	int¹		1		CSA	2
rs1258255^1,2	C,F,A,H	--	50942289(+)	`TGGCGC/TAGTGG`	3	--	int¹		10		NA WA CSA EA	373
rs1985896^1,2	C,F	--	50942419(+)	`TAGCCA/GGGCAT`	3	--	int¹		3		NA	6
rs188574912^1,2		--	50942457(+)	`CTCAGA/GAGGCT`	3	--	int¹		0	--	--	--	--
rs139446919^1,2		--	50942493(+)	`GGAGGC/TGGAGG`	3	--	int¹		0	--	--	--	--
rs191652353^1,2		--	50942494(+)	`GAGGCA/GGAGGT`	3	--	int¹		0	--	--	--	--
rs75100229^1,2	F	--	50942558(+)	`ACTCCG/ATCTCA`	3	--	int¹		1		NA	120
rs114659596^1,2		--	50942605(+)	`CATTTT/GTTTAA`	3	--	int¹		1		WA	118
rs6816^1,2	C,F,O,A,H	--	50942763(+)	`TTTCAC/TACAGA`	3	--	ut3¹ ese³		31		MN EA NA NS WA	3258

HapMap Linkage Disequilibrium report for OGDHL (50942687 - 50970425 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OGDHL
1 Indel: 100943

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OGDHL for disorders About GeneDecksing

5 diseases for OGDHL: About MalaCards

kidney disease alzheimer's disease tuberculosis malaria

mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: OGDHL (5 documents)

Export disorders for OGDHL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OGDHL gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with OGDHL)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2, 3} Nagase T.... Ohara O. (1999)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins. (PubMed id 18004749)^{1, 9} Bunik V.I. and Degtyarev D. (2008)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)¹ Oguri M....Yamada Y. (2010)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)¹ Yoshida T....Yamada Y. (2010)
Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)¹ Yoshida T....Yamada Y. (2009)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)¹ Grupe A....Goate A. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55753	HGNC: 25590	AceView: OGDHL	Ensembl:ENSG00000197444	euGenes: HUgn55753
ECgene: OGDHL	Kegg: 55753	H-InvDB: OGDHL

(According to HUGE)
About This Section

HUGE: KIAA1290

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OGDHL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for OGDHL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for OGDHL gene:
Search GeneIP for patents involving OGDHL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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