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OGDHL Gene

protein-coding   GIFtS: 58
GCID: GC10M050942

Oxoglutarate Dehydrogenase-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oxoglutarate Dehydrogenase-Like1 2     2-Oxoglutarate Dehydrogenase-Like, Mitochondrial2
Alpha-Ketoglutarate Dehydrogenase-Like2 3     EC 1.2.4.-3
2-Oxoglutarate Dehydrogenase Complex Component E1-Like2 3     KIAA12903
OGDC-E1-like2 3     EC 1.2.4.28

External Ids:    HGNC: 255901   Entrez Gene: 557532   Ensembl: ENSG000001974447   UniProtKB: Q9ULD03   

Export aliases for OGDHL gene to outside databases

Previous GC identifers: GC10M050288 GC10M050612 GC10M045207


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OGDHL Gene:
OGDHL (oxoglutarate dehydrogenase-like) is a protein-coding gene. GO annotations related to this gene include oxoglutarate dehydrogenase (succinyl-transferring) activity and thiamine pyrophosphate binding. An important paralog of this gene is DHTKD1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the OGDHL gene promoter:
         GATA-3   HTF   NRSF form 1   Tal-1beta   NRSF form 2   E47   N-Myc   S8   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOGDHL promoter sequence
   Search Chromatin IP Primers for OGDHL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OGDHL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.23

OGDHL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OGDHL gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M050942:  view genomic region     (about GC identifiers)

Start:
50,942,687 bp from pter      End:
50,970,425 bp from pter
Size:
27,739 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OGDHL_HUMAN, Q9ULD0 (See protein sequence)
Recommended Name: 2-oxoglutarate dehydrogenase-like, mitochondrial precursor  
Size: 1010 amino acids; 114481 Da
Cofactor: Thiamine pyrophosphate (By similarity)
Sequence caution: Sequence=BAA86604.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K2G1 B4DKG2 B4E193 Q8TAN9 Q9NVA0
Alternative splicing: 3 isoforms:  Q9ULD0-1   Q9ULD0-2   Q9ULD0-3   

Explore the universe of human proteins at neXtProt for OGDHL: NX_Q9ULD0

Explore proteomics data for OGDHL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for OGDHL (Q9ULD0) (see all 29)
     RLSGQDV  GQAKWVR  DLVCYRR  KSLLRHP 


    See OGDHL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001137468.1  NP_001137469.1  NP_060715.2  

    ENSEMBL proteins: 
     ENSP00000363216   ENSP00000401356   ENSP00000390240  

    OGDHL Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for OGDHL

     
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    Cloud-Clone Corp. CLIAs for OGDHL
    Search eBioscience for ELISAs for OGDHL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011603 2oxoglutarate_DH_E1
     IPR005475 Transketolase-like_Pyr-bd
     IPR001017 DH_E1

    Graphical View of Domain Structure for InterPro Entry Q9ULD0

    ProtoNet protein and cluster: Q9ULD0

    1 Blocks protein domain: IPB005475 Transketolase

    UniProtKB/Swiss-Prot: OGDHL_HUMAN, Q9ULD0
    Similarity: Belongs to the alpha-ketoglutarate dehydrogenase family


    Find genes that share domains with OGDHL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for OGDHL:
    alpha-ketoglutarate dehydrogenase,E1k subunit-like sequence

         Enzyme Numbers (IUBMB): EC 1.2.4.22 EC 1.2.4.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity IEA--
    GO:0005515protein binding IPI--
    GO:0016624oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor ----
    GO:0030976thiamine pyrophosphate binding IEA--
         
    Find genes that share ontologies with OGDHL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OGDHL:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OGDHL
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OGDHL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OGDHL

    miRNA
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    miRTarBase miRNAs that target OGDHL:
    hsa-mir-335-5p (MIRT018923), hsa-mir-130b-5p (MIRT038289)

    Block miRNA regulation of human, mouse, rat OGDHL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OGDHL (see all 10):
    hsa-miR-1263 hsa-miR-4263 hsa-miR-139-5p hsa-miR-138-1* hsa-miR-9 hsa-miR-659 hsa-miR-3622b-3p hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidOGDHL 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OGDHL

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): OGDHL (NM_001143996)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OGDHL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGDHL

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGDHL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OGDHL_HUMAN, Q9ULD0: Mitochondrion matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005759mitochondrial matrix IEA--

    Find genes that share ontologies with OGDHL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OGDHL About    
    See pathways by source

    SuperPathContained pathways About
    1Citric acid cycle (TCA cycle)
    Citrate cycle (TCA cycle)0.55
    2Tryptophan metabolism
    Tryptophan metabolism0.46
    3Carbon metabolism
    Carbon metabolism0.38
    4Metabolism
    Metabolic pathways0.38
    5Lysine degradation
    Lysine degradation


    Find genes that share SuperPaths with OGDHL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5 Kegg Pathways  (Kegg details for OGDHL):
        Citrate cycle (TCA cycle)
    Lysine degradation
    Tryptophan metabolism
    Metabolic pathways
    Carbon metabolism

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OGDHL: 
              Amino Acid Metabolism II in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for OGDHL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OGDHL (Q9ULD01 ENSP000003632164) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT3P407631, ENSP000002646574EBI-3940481,EBI-518675 STRING: ENSP00000264657
    AADATENSP000002268404STRING: ENSP00000226840
    DLDENSP000002054024STRING: ENSP00000205402
    DLSTENSP000003353044STRING: ENSP00000335304
    IDH1ENSP000002609854STRING: ENSP00000260985
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006096glycolytic process IEA--
    GO:0006099tricarboxylic acid cycle IEA--
    GO:0008152metabolic process ----
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with OGDHL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OGDHL

    Selected HMDB Compounds for OGDHL (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Ketobutyric acid2-Ketobutanoate (see all 35)600-18-0--
    3-carboxy-1-hydroxypropylthiamine diphosphate3-Carboxy-1-hydroxypropyl-ThPP (see all 3)----
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Glutaryl-CoAglutaryl-CoA (see all 2)103192-48-9--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Oxoadipic acidalpha-ketoadipic acid (see all 19)3184-35-8--
    Oxoglutaric acid2-Ketoglutarate (see all 9)328-50-7--
    S-Glutaryldihydrolipoamide ----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OGDHL gene (3 alternative transcripts): 
    NM_001143996.1  NM_001143997.1  NM_018245.2  

    Unigene Cluster for OGDHL:

    Oxoglutarate dehydrogenase-like
    Hs.17860  [show with all ESTs]
    Unigene Representative Sequence: NM_018245
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374103(uc009xog.3 uc001jie.3 uc009xoh.2) ENST00000490844
    ENST00000496884 ENST00000471460 ENST00000419399(uc010qgt.2) ENST00000432695(uc010qgu.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat OGDHL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OGDHL (see all 10):
    hsa-miR-1263 hsa-miR-4263 hsa-miR-139-5p hsa-miR-138-1* hsa-miR-9 hsa-miR-659 hsa-miR-3622b-3p hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidOGDHL 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): OGDHL (NM_001143996)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OGDHL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGDHL
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for OGDHL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OGDHL
      QuantiTect SYBR Green Assays in human, mouse, rat OGDHL
      QuantiFast Probe-based Assays in human, mouse, rat OGDHL

    Additional mRNA sequence: 

    AB033116.3 AK001713.1 AK290226.1 AK296551.1 AK303729.1 AK307759.1 BC026320.1 

    9 DOTS entries:

    DT.412735  DT.95160623  DT.100777896  DT.100000713  DT.92452437  DT.95193102  DT.121290645  DT.92452444 
    DT.102826111 

    Selected AceView cDNA sequences (see all 93):

    BU165087 BU787591 CR603720 CD671366 AW149004 BF313582 BX482149 AB033116 
    CD671333 BQ613930 BU732141 AI289176 AW664293 AU159536 N51727 BM504223 
    BX332098 AK001713 AU133174 NM_018245 AU142192 AI215507 AA948651 BM714440 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OGDHL (see all 17)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a ·
    SP1:                          -     -     -           -                             -     -                                                     -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:              -     -     -     -     -     -     -                             -     -                                                                     
    SP5:                          -     -     -     -     -                             -     -                                                                     

    ExUns: 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b · 27c · 27d
    SP1:                                                                    -                       -                                             
    SP2:                                                  -                                                                                       
    SP3:                                                                                            -                                             
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for OGDHL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OGDHL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCAGAGAG
    OGDHL Expression
    About this image

    OGDHL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OGDHL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.17860
        Pathway & Disease-focused RT2 Profiler PCR Arrays including OGDHL: 
              Amino Acid Metabolism II in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGDHL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OGDHL gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ogdhl1 , 5 oxoglutarate dehydrogenase-like1, 5 87.62(n)1
    93.17(a)1
      14 (19.40 cM)5
    2390171  NM_001081130.11  NP_001074599.11 
     323220195 
    chicken
    (Gallus gallus)
    Aves OGDHL1 oxoglutarate dehydrogenase-like 74.51(n)
    86.41(a)
      423618  NM_001199544.1  NP_001186473.1 
    lizard
    (Anolis carolinensis)
    Reptilia OGDHL6
    oxoglutarate dehydrogenase-like
    83(a)
    1 ↔ 1
    GL343199.1(3628323-3691993)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ogdhl1 oxoglutarate dehydrogenase-like 72.82(n)
    83.32(a)
      100497480  XM_002933905.2  XP_002933951.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ogdhl1 oxoglutarate dehydrogenase-like 73.1(n)
    81.11(a)
      559207  XM_682523.4  XP_687615.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nc73EF6
    CG337916
    --
    56(a)
    42(a)
    many ↔ many
    many ↔ many
    3L(16948035-16961824)
    3L(1602954-1617355)
    worm
    (Caenorhabditis elegans)
    Secernentea ogdh-16
    Protein OGDH-1 (ogdh-1) mRNA, complete cds
    55(a)
    1 → many
    IV(4696835-4704011) WBGene00020679
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KGD16
    Component of the mitochondrial alpha-ketoglutarate...
    44(a)
    1 → many
    IX(122689-125733) YIL125W
    rice
    (Oryza sativa)
    Liliopsida Os.139262 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.5(n)    AK100482.1 


    ENSEMBL Gene Tree for OGDHL (if available)
    TreeFam Gene Tree for OGDHL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OGDHL gene
    DHTKD12  OGDH2  
    2 SIMAP similar genes for OGDHL using alignment to 1 protein entry:     OGDHL_HUMAN:
    OGDH    DHTKD1

    Find genes that share paralogs with OGDHL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OGDHL (see all 891)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114017681,2
    C,F--50942206(+) CAGTAC/TCTCCA 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs12582551,2
    C,F,A,H--50942289(+) TGGCGC/TAGTGG 3 -- int110Minor allele frequency- T:0.47NA WA CSA EA 373
    rs19858961,2
    C,F--50942419(+) TAGCCA/GGGCAT 3 -- int13Minor allele frequency- G:0.33NA 6
    rs1885749121,2
    --50942457(+) CTCAGA/GAGGCT 3 -- int10--------
    rs1394469191,2
    C--50942493(+) GGAGGC/TGGAGG 3 -- int10--------
    rs1916523531,2
    --50942494(+) GAGGCA/GGAGGT 3 -- int10--------
    rs751002291,2
    C,F--50942558(+) ACTCCG/ATCTCA 3 -- int11Minor allele frequency- A:0.05NA 120
    rs1146595961,2
    F--50942605(+) CATTTT/GTTTAA 3 -- int11Minor allele frequency- G:0.01WA 118
    rs68161,2
    C,F,O,A,H--50942763(+) TTTCAC/TACAGA 3 -- ut31 ese331Minor allele frequency- T:0.44MN EA NA NS WA 3258
    rs1838419581,2
    --50943058(+) ACAGTA/TGCCTG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for OGDHL (50942687 - 50970425 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OGDHL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2588189CNV Insertion19546169
    nsv895365CNV Loss21882294
    nsv895375CNV Gain21882294
    nsv895378CNV Gain21882294
    nsv7203OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OGDHL
    DNA2.0 Custom Variant and Variant Library Synthesis for OGDHL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OGDHL           About GenesLikeMe

    Genetic Association Database (GAD): OGDHL
    Human Genome Epidemiology (HuGE) Navigator: OGDHL (5 documents)

    Export disorders for OGDHL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OGDHL gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with OGDHL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    5. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins. (PubMed id 18004749)1, 9 Bunik V.I. and Degtyarev D. (Proteins 2008)
    9. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    10. OGDHL is a modifier of AKT-dependent signaling and NF-I_B function. (PubMed id 23152800)1 Sen T....Hoque M.O. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55753 HGNC: 25590 AceView: OGDHL Ensembl:ENSG00000197444 euGenes: HUgn55753
    ECgene: OGDHL Kegg: 55753 H-InvDB: OGDHL

    (According to HUGE)
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    HUGE: KIAA1290

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for OGDHL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OGDHL gene:
    Search GeneIP for patents involving OGDHL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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