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OGDH Gene

protein-coding GIFtS: 56

GC07P044612

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AKGDH ^²
E1k ^¹, ²
EC 1.2.4.2 ^³
H_DJ0691F11_gi16307008.sp_cds.1 ^²
OGDC ^²

Descriptions
2-oxoglutarate dehydrogenase ^²
Alpha-ketoglutarate dehydrogenase ^³
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) ^²
oxoglutarate decarboxylase' ^²
oxoglutarate dehydrogenase (lipoamide) ^²
oxoglutarate dehydrogenase (succinyl-transferring) ^²

External Ids
HGNC: 8124¹
Entrez Gene: 4967²
UniProtKB: Q02218³
Ensembl: ENSG00000105953⁷

Search outside databases for aliases for OGDH gene

Previous GC identifers: GC07P044292 GC07P044387 GC07P044419

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OGDH:

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes

the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during

the Krebs cycle. The protein is located in the mitocondrial matrix and uses thiamine pyrophosphate

as a cofactor. A congential deficiency in 2-oxoglutarate dehydrogenase activity is believed to

lead to hypotonia, metabolic acidosis, and hyperlactatemia. [provided by RefSeq]

UniProtKB/Swiss-Prot: ODO1_HUMAN, Q02218

Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of

2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic

components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and

lipoamide dehydrogenase (E3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OGDH gene

Entrez Gene cytogenetic band: 7p14-p13 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13-p11.2

OGDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P044612: (about GC identifiers)

Start:	44,612,696 bp from pter
End:	44,715,194 bp from pter
Size:	102,499 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 44,685,689-44,788,190

RefSeq DNA sequence:

NC_000007.12 NT_007819.16 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ODO1_HUMAN, Q02218 (See protein sequence)

Recommended Name: 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor

Size: 1023 amino acids; 115935 Da

Cofactor: Thiamine pyrophosphate

Subcellular location: Mitochondrion matrix

Sequence caution: Sequence=BAA01393.1; Type=Frameshift; Positions=1003; Sequence=BAA06836.1;

Type=Frameshift; Positions=1003;

PDB structures from and Proteopedia :

3ERY (3D)

Secondary accessions: Q9UDX0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001003941.1 NP_002532.2

ENSEMBL proteins:

ENSP00000222673

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for OGDH
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005759	mitochondrial matrix	IEA	--
GO:0031966	mitochondrial membrane	ISS	--

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Antibodies for OGDH:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for OGDH
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OGDH

Assays for OGDH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q02218

ProtoNet protein and cluster: Q02218

1 Blocks protein family: IPB005475 Transketolase

UniProtKB/Swiss-Prot: ODO1_HUMAN, Q02218

Similarity: Belongs to the alpha-ketoglutarate dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OGDH)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002541

Applied Biosystems Silencer® siRNAs for OGDH

Sigma-Aldrich siRNA and siRNA Panels for OGDH

Sigma-Aldrich shRNA Panels and shRNA for OGDH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001003941
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001003941
untagged cDNA clones in CMV expression vector (see all 4): BC009580

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002541

UniProtKB/Swiss-Prot: ODO1_HUMAN, Q02218

Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of

2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic

components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and

lipoamide dehydrogenase (E3)

Catalytic activity: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine

= [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2)

Enzyme regulation: Catabolite repressed

Enzyme Number (IUBMB): EC 1.2.4.2

Genatlas biochemistry entry for OGDH:

2-oxoglutarate lipoamide 2 oxidoreductase (decarboxylating and acceptor-succinylating,component E1

of the 2-oxoglutarate complex,mitochondrial matrix

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	ISS	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0030976	thiamin pyrophosphate binding	IEA	--
GO:0034602	oxoglutarate dehydrogenase (NAD+) activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for OGDH (Your Favorite Gene powered by Ingenuity)

Citrate Cycle
Mitochondrial Dysfunction
Lysine Degradation
Tryptophan Metabolism

GeneDecks OGDH for the pathways selected above

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5/31 Interacting proteins for OGDH (ENSP00000222673³) via UniProtKB, MINT, and/or STRING (see all 31 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLD	ENSP00000205402³	STRING (score=.999)
DLST	ENSP00000335304³	STRING (score=.999)
CS	ENSP00000342056³	STRING (score=.956)
IDH2	ENSP00000331897³	STRING (score=.921)
PDHX	ENSP00000227868³	STRING (score=.916)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006096	glycolysis	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OGDH
10/32 Novoseek chemical compound relationships for OGDH gene (see all 32 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lspfpfdl	86.63	1	11207252 (1)
pyruvate	85.27	80	2188870 (3), 1722146 (2), 8835931 (2), 16338405 (2) (see all 64)
dihydrolipoamide	84.82	14	1505515 (2), 12464489 (1), 8619544 (1), 16045627 (1) (see all 11)
2-oxo acid	83.75	8	9089910 (1), 10385636 (1), 7548757 (1), 8617422 (1) (see all 5)
lipoamide	79.03	10	1722146 (2), 1542694 (2), 12590611 (1), 16045627 (1) (see all 5)
alpha-ketoadipate	78.16	2	8495733 (2)
nadh	68.74	12	11124972 (2), 2087902 (1), 2117555 (1), 2233821 (1) (see all 9)
succinic semialdehyde	66.96	1	10812195 (1)
isocitrate	65.30	7	9746330 (1), 17668068 (1), 12668482 (1), 14526533 (1) (see all 6)
coash	55.20	1	10790315 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OGDH)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002541

Sigma-Aldrich siRNA and siRNA Panels for OGDH

Sigma-Aldrich shRNA Panels and shRNA for OGDH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001003941 NM_002541

REFSEQ mRNAs for OGDH gene (2 alternative transcripts):

NM_001003941.1 NM_002541.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001003941 NM_002541

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001003941
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001003941
                                 untagged cDNA clones in CMV expression vector (see all 4): BC009580

Additional cDNA sequence:

AK293871.1 AK294951.1 AK296400.1 AK302805.1 AK304439.1 AK304690.1 AK314179.1 BC004964.1

BC009580.1 BC014617.2 BC128549.1 BC128550.1 CR598912.1 CR610956.1 CR613315.1 CR617563.1

CR617767.1 D10523.1 DQ925673.1 DQ925674.1

24/37 DOTS entries (see all 37 ):

DT.118120 DT.100791852 DT.97857885 DT.100735380 DT.75200206 DT.121112033 DT.100791854 DT.95155237

DT.100791846 DT.100039132 DT.121112040 DT.40206351 DT.100791848 DT.121112036 DT.40242179 DT.92452428

DT.100791843 DT.121112047 DT.121112054 DT.121112062 DT.97862311 DT.102833542 DT.121112002 DT.121112026

24/500 AceView cDNA sequences (see all 500 ):

CA396416 BU526945 BM005784 CK724952 AA329688 CA488892 AU133291 BG756625

BQ941210 BQ224918 CR613315 BE744600 BF115199 BM809865 BQ951983 BX331800

BQ954636 BE315070 BQ925256 BU506784 BP337046 CR610956 BE904469 BE384690

highest scoring ESTs for OGDH:

AI697389 D10523 AA005109 AA025473 AA095266 AA095571 AA126056 AA159542 AA179435 AA181761

Unigene Cluster for OGDH:

Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

Hs.488181 [show with all ESTs]

Unigene Representative Sequence: NM_002541

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for OGDH (see all 17 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	·	5d	·	5e	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10a	·
SP1:																																							-				-
SP2:											-		-		-		-										-												-				-
SP3:											-		-		-		-		-								-												-				-
SP4:													-		-		-		-								-												-				-
SP5:

ExUns:	10b	·	10c	·	10d	^	11a	·	11b	·	11c	·	11d	^	12	^	13a	·	13b	·	13c	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	·	18c	^	19	^	20a	·	20b	^	21	^	22	^	23	^	24	^
SP1:													-								-						-
SP2:
SP3:
SP4:
SP5:													-

ExUns:	25	^	26	^	27
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for OGDH

1 Ensembl transcript including schematic representation:

ENST00000222673

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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OGDH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OGDH

¹ / ² / ³

6 probe-sets matching OGDH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40470_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.69	D10523	1.00	1.00	1.00	1
78194_at²^{, 3}	U95-E	1	1.00	1.00	0.97	1.32	AI697389	1.00	1.00	1.00	1
201282_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002541	0.60	1.00	0.82	1
201282_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554152_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554151_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks OGDH for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCAAGGGGC

SOURCE GeneReport for Unigene cluster: Hs.488181
Expression variation in blood from EXPOLDB for OGDH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for OGDH gene from 5/24 species (see all 24 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OGDH¹	--	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	89.4(n) 98.39(a)	475499 XM_532722.2 XP_532722.2
chimpanzee (Pan troglodytes)	OGDH¹	--	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	99.64(n) 100(a)	738474 XM_001146811.1 XP_001146811.1
cow (Bos taurus)	OGDH¹	--	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	90.16(n) 98.24(a)	534599 NM_001076030.1 NP_001069498.1
rat (Rattus norvegicus)	Ogdh¹	--	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	89.44(n) 96.29(a)	360975 NM_001017461.1 NP_001017461.1
mouse (Mus musculus)	Ogdh^{1, 5}	11⁵	oxoglutarate dehydrogenase (lipoamide)^{1, 5}	89.21(n)¹ 95.89(a)¹	18293¹ NM_010956.3¹ NP_035086.2¹ AA409584⁵ AI324749⁵ (see all 53)

About this table Species with no ortholog for OGDH

ENSEMBL Gene Tree for OGDH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for OGDH gene

DHTKD1² OGDHL²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/425 NCBI SNPs in OGDH are shown (see all 425 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 104)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1058128^1,2	A,C,F	44714976(+)	`GCATCG/ATTTTC`	1	--	ut3¹		4	MN NA	320
	rs12868^1,2	A,C,F	44714855(+)	`CCACCG/ACCGGG`	1	--	ut3¹ ese³		5	MN NA	512
	rs14239^1,2	C,F,H	44714428(+)	`CACAAT/CCCTCC`	1	--	ut3¹ ese³		9	MN EU EA WA NA	2214
	rs2070607^1,2	C,F,H	44714103(+)	`TGGACG/ATCTTC`	1	I/V	mis¹ ese³		11	NA EU EA WA	976
--	rs17522884^1,2	F	44612659(+)	`GGGAGG/AGCATT`	2	--	ng5¹ tfbs³ trp³		4	MN EA	712
	rs799438^1,2	H	44715072(+)	`CATTTA/GTCACT`	1	--	ut3¹		5	MN EU EA WA	602
--	rs17551563^1,2	F	44612710(+)	`GGCGGG/AGCCGA`	2	--	ut5¹ ese³		2	MN EA	356
	rs2070606^1,2	C,F,H,O	44714024(+)	`CCAGCG/AGCTGC`	1	A/A	syn¹ ese³		7	EA NA EU	1504
	rs34777281^1,2	F	44630506(+)	`AGGCCA/CTTGAC`	2	P/P	syn¹		1	NA	92
	rs886651^1,2	A,C,F,H,O	44636679(+)	`AAATAC/TATGTa`	2	--	int¹		11	EU EA WA NA	980

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HapMap Linkage Disequilibrium images for OGDH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 203740

10/16 Novoseek disease relationships for OGDH gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
door syndrome	74.89	1	17343268 (1)
biliary cirrhosis primary	72.67	12	2188870 (2), 9089910 (1), 1380527 (1), 10385636 (1) (see all 11)
thiamine deficiency	71.36	3	8683340 (1), 19067139 (1)
korsakoff syndrome	54.71	1	8279670 (1)
alzheimers disease	38.44	3	8619544 (1), 2087217 (1), 15663478 (1)
neurodegenerative diseases	38.23	3	19087395 (1), 15840571 (1), 15663478 (1)
neurodegeneration	36.58	2	18783430 (1)
parkinson disease	27.12	3	8986127 (1), 19087395 (1), 12963742 (1)
autoimmune response	15.93	3	8527402 (1)
mimicry	14.82	1	7548757 (1)

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Genatlas disease: OGDH

congenital lactic acidosis with hypotonia and progressive neurologic deterioration leading to

early death

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/179 PubMed articles for OGDH gene (see all 179 ):

Cloning and nucleotide sequence of the cDNA encoding human 2-oxoglutarate dehydrogenase (lipoamide). (PubMed id 1542694)^{1, 2, 3, 4} Koike K....Goto S. (1992)
Localization of the gene (OGDH) coding for the E1k component of the alpha-ketoglutarate dehydrogenase complex to chromosome 7p13-p11.2. (PubMed id 8020988)^{1, 2, 3} Szabo P....Blass J.P. (1994)
The gene encoding human 2-oxoglutarate dehydrogenase: structural organization and mapping to chromosome 7p13-p14. (PubMed id 7622061)^{1, 3, 4} Koike K. (1995)
Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. (PubMed id 15649899)^{1, 3} Shi Q....Gibson G.E. (2005)
Exclusion of OGDH and BMP4 as candidate genes in two siblings with autosomal recessive DOOR syndrome. (PubMed id 17343268)^{1, 3} van Bever Y....Courtens W. (2007)
Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah. (PubMed id 15466852)^{1, 3} Habelhah H....Ronai Z. (2004)
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)⁴ Denis N.J.... Figeys D. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4967	HGNC: 8124	AceView: OGDH	Ensembl:ENSG00000105953	euGenes: HUgn4967
ECgene: OGDH	H-InvDB: OGDH

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Alpha-ketoglutarate_dehydrogenase

Licensable Technologies for OGDH
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OGDH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OGDH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OGDH		Antibodies for OGDH
	Explore super-pooled esiRNAs		Proteins for OGDH
	Lentivirus-delivered shRNAs for OGDH		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

Search OriGene for OGDH

Search Tocris compounds for OGDH

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for OGDH

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
OGDH Gene at Home site.
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OGDH Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for OGDH

Summaries
for OGDH

Genomic Location
for OGDH

Proteins
for OGDH

Protein Domains/
Families
for OGDH

Gene Function
for OGDH

Pathways & Interactions
for OGDH

Drugs & Compounds
for OGDH

Transcripts
for OGDH

Expression
for OGDH

Orthologs
for OGDH

Paralogs
for OGDH

SNPs/Variants
for OGDH

Disorders & Mutations
for OGDH

Medical News
for OGDH

Publications
for OGDH

Search for OGDH

Genome Databases showing OGDH

Other Databases showing OGDH

Specialized Databases showing OGDH

Licensable Technologies
for OGDH

Services
for OGDH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OGDH Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor OGDH

Summariesfor OGDH

Genomic Locationfor OGDH

Proteinsfor OGDH

Protein Domains/Familiesfor OGDH

Gene Functionfor OGDH

Pathways & Interactionsfor OGDH

Drugs & Compoundsfor OGDH

Transcriptsfor OGDH

Expression for OGDH

Orthologsfor OGDH

Paralogsfor OGDH

SNPs/Variantsfor OGDH

Disorders & Mutationsfor OGDH

Medical Newsfor OGDH

Publicationsfor OGDH

Search for OGDH

Genome Databases showing OGDH

Other Databases showing OGDH

Specialized Databases showing OGDH

Licensable Technologiesfor OGDH

Servicesfor OGDH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OGDH

Summaries
for OGDH

Genomic Location
for OGDH

Proteins
for OGDH

Protein Domains/
Families
for OGDH

Gene Function
for OGDH

Pathways & Interactions
for OGDH

Drugs & Compounds
for OGDH

Transcripts
for OGDH

Expression
for OGDH

Orthologs
for OGDH

Paralogs
for OGDH

SNPs/Variants
for OGDH

Disorders & Mutations
for OGDH

Medical News
for OGDH

Publications
for OGDH

Licensable Technologies
for OGDH

Services
for OGDH