OGDH Gene
protein-coding GIFtS: 63
GCID: GC07P044646
|
|
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
| |
Aliases
for OGDH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oxoglutarate (Alpha-Ketoglutarate) Dehydrogenase (Lipoamide)1 2 | | AKGDH2 | | E1k1 2 | | OGDC2 | | 2-Oxoglutarate Dehydrogenase Complex Component E12 3 | | Oxoglutarate Decarboxylase2 | | OGDC-E12 3 | | Oxoglutarate Dehydrogenase (Succinyl-Transferring)2 | | EC 1.2.4.23 8 | | Alpha-Ketoglutarate Dehydrogenase3 | | 2-Oxoglutarate Dehydrogenase, Mitochondrial2 | | |
Export aliases for OGDH gene to outside databasesPrevious GC identifers: GC07P044292 GC07P044387 GC07P044419 GC07P044612 |
Summaries
for OGDH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OGDH:
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overallconversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein islocated in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia.Alternative splicing results in multiple transcript variants encoding distinct isoforms.(provided by RefSeq, Sep 2009)
UniProtKB/Swiss-Prot: ODO1_HUMAN, Q02218Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoAand CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1),dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
Gene Wiki entry for OGDH
|
Genomic Views
for OGDH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OGDH gene promoter:
Max1 p53 Pax-6 Lmo2 E4BP4 SREBP-1b Egr-4 SREBP-1a ATF6 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for OGDH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OGDH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p14-p13 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13-p11.2OGDH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P044646: view genomic region
(about GC identifiers)
Start:
|
44,646,121 bp from pter |
End:
|
44,748,669 bp from pter |
Size:
|
102,549 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 44,685,639-44,788,190 |
|
Proteins
for OGDH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ODO1_HUMAN, Q02218 (See
protein sequence)Recommended Name: 2-oxoglutarate dehydrogenase, mitochondrial precursor Size: 1023 amino acids; 115935 Da
Cofactor: Thiamine pyrophosphate
Subcellular location: Mitochondrion matrix
Sequence caution: Sequence=BAA01393.1; Type=Frameshift; Positions=1003; Sequence=BAA06836.1; Type=Frameshift;Positions=1003;
1 PDB 3D structure from  and Proteopedia  for OGDH:3ERY (3D)
Secondary accessions: B4E2U9 D3DVL0 E9PBM1 Q96DD3 Q9UDX0Alternative splicing: 3 isoforms: Q02218-1 Q02218-2 Q02218-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for OGDH: NX_Q02218
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q02218
4/38 DME Specific Peptides for OGDH (Q02218) (see all 38)
OGDH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001003941.1 NP_001158508.1 NP_002532.2
ENSEMBL proteins: ENSP00000398576 ENSP00000388084 ENSP00000392878 ENSP00000388183 ENSP00000411830 ENSP00000414662 ENSP00000222673 ENSP00000443821 Reactome Protein details: Q02218
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
OGDH for ontologies About GeneDecksing
OGDH Antibody Products:
Assay Products for OGDH: |
Protein
Domains /
Families
for OGDH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OGDH for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q02218ProtoNet protein and cluster: Q02218 1 Blocks protein family: IPB005475 Transketolase
UniProtKB/Swiss-Prot: ODO1_HUMAN, Q02218Similarity: Belongs to the alpha-ketoglutarate dehydrogenase family |
Function
for OGDH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ODO1_HUMAN, Q02218Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoAand CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1),dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)Catalytic activity: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine =[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2)Enzyme regulation: Catabolite repressed Genatlas biochemistry entry for OGDH:2-oxoglutarate lipoamide 2 oxidoreductase (decarboxylating and acceptor-succinylating,component E1 of the2-oxoglutarate complex,mitochondrial matrix
Enzyme Number (IUBMB): EC 1.2.4.21 2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OGDH (see all 5)
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Synthesis Service for OGDH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGDH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGDH |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity |
ISS | -- | | GO:0030976 | thiamine pyrophosphate binding |
IEA | -- | | GO:0031072 | heat shock protein binding |
IEA | -- | | GO:0034602 | oxoglutarate dehydrogenase (NAD+) activity |
IEA | -- | | GO:0051087 | chaperone binding |
IEA | -- |
OGDH for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for OGDH:
|
Pathways & Interactions
for OGDH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TCA Cycle | | | 2 | Lysine catabolism | | | 3 | Metabolism | | | 4 | Tryptophan metabolism | | | 5 | TCA cycle II (eukaryotic) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4  BioSystems Pathways for OGDH
5/6 
Reactome Pathways for OGDH (see all 6)
1  PharmGKB Pathway for OGDH
4 
Kegg Pathways (Kegg details for OGDH):
OGDH for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OGDH
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/127 Interacting proteins for OGDH (Q022183 ENSP000002226734) via UniProtKB, MINT, STRING, and/or I2D (see all 127)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006091 | generation of precursor metabolites and energy |
ISS | -- | | GO:0006096 | glycolysis |
IEA | -- | | GO:0006099 | tricarboxylic acid cycle |
TAS | -- | | GO:0006103 | 2-oxoglutarate metabolic process |
IEA | -- | | GO:0006104 | succinyl-CoA metabolic process |
IEA | -- |
OGDH for ontologies About GeneDecksing
|
Drugs & Compounds
for OGDH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
OGDH for compounds About GeneDecksing
 Browse Tocris compounds for OGDH
10/16 HMDB Compounds for OGDH (see all 16) About this table
1 DrugBank Compound for OGDH About this table
10/55 Novoseek chemical compound relationships for OGDH gene (see all 55) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| alpha-ketoglutarate |
97.3 |
313 |
1912072 (5), 18783430 (4), 11124972 (4), 18081316 (4) (see all 99) |
| lspfpfdl |
86.3 |
1 |
11207252 (1) |
| dihydrolipoamide |
85.1 |
15 |
1505515 (2), 12464489 (1), 20106611 (1), 8619544 (1) (see all 12) |
| pyruvate |
84.9 |
82 |
2188870 (3), 1722146 (2), 8835931 (2), 16338405 (2) (see all 66) |
| 2-oxo acid |
83.2 |
8 |
9089910 (1), 10385636 (1), 7548757 (1), 8617422 (1) (see all 5) |
| lipoamide |
78 |
10 |
1722146 (2), 1542694 (2), 12590611 (1), 16045627 (1) (see all 5) |
| alpha-ketoadipate |
77.7 |
2 |
8495733 (2) |
| alpha lipoic acid |
76.8 |
10 |
18081316 (2), 1912072 (1), 18655815 (1), 2104971 (1) (see all 9) |
| thiamine pyrophosphate |
74.6 |
9 |
8835931 (2), 19043979 (2), 8279670 (1), 9521628 (1) |
| isocitrate |
69.9 |
10 |
9746330 (1), 17668068 (1), 20109171 (1), 20394787 (1) (see all 9) |
Search CenterWatch for drugs/clinical trials and news about OGDH / ODO1
|
Transcripts
for OGDH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OGDH gene (3 alternative transcripts): NM_001003941.2 NM_001165036.1 NM_002541.3 Unigene Cluster for OGDH: Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) Hs.488181 [show with all ESTs]Unigene Representative Sequence: NM_00254110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000439616 ENST00000443864(uc003tlm.3) ENST00000449767 ENST00000447398
ENST00000419661 ENST00000444676(uc003tlo.1) ENST00000222673(uc011kbx.2 uc003tln.3 uc011kby.2 uc003tlp.3 uc011kbz.2)
ENST00000459672 ENST00000497326 ENST00000543843
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OGDH (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OGDH (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): OGDH (NM_002541) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OGDH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGDH |
Additional cDNA sequence: AK293871.1 AK296400.1 AK304439.1 AK304690.1 AK314179.1 BC004964.1 BC009580.1 BC014617.2 BC128549.1 BC128550.1 D10523.1 DQ925673.1 DQ925674.1 24/39 DOTS entries (see all 39): DT.118120 DT.100791852 DT.97857885 DT.100735380 DT.75200206 DT.121112033 DT.100791854 DT.95155237 DT.100791846 DT.100039132 DT.121112040 DT.40206351 DT.100791848 DT.121112036 DT.40242179 DT.92452428 DT.100791843 DT.121112031 DT.121112047 DT.121112054 DT.97862311 DT.102833542 DT.121112002 DT.121112026 24/500 AceView cDNA sequences (see all 500): BQ436417 BM824479 CR610956 CR617563 BQ650908 BQ669845 BE315070 BG746617 BU850137 BQ948774 CA393946 BQ941210 BM713604 CA393598 BM475657 BU506784 BC009580 BM126371 BE384690 NM_002541 CR613315 CA396416 BM907253 BM697344
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for OGDH (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 25 | ^ | 26 | ^ | 27 |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for OGDH
|
Expression
for OGDH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OGDH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAAGGGGC
About this image
See OGDH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OGDH
SOURCE GeneReport for Unigene cluster: Hs.488181
SABiosciences Expression via Pathway-Focused PCR Arrays including OGDH: | Amino Acid Metabolism II in human mouse rat | | Molecular Toxicology PathwayFinder 384HT in human mouse rat | | Glucose Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OGDH
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGDH |
Orthologs
for OGDH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for OGDH gene from 10/40 species (see all 40) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
OGDH1 |
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) |
82.78(n)
91.83(a) |
|
426429 NM_001031382.1 NP_001026553.1 |
lizard
(Anolis carolinensis) |
Reptilia |
OGDH6 |
-- |
93(a) |
1 ↔ 1 |
GL343238.1(798191-829882) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC688002 |
hypothetical protein MGC68800 |
78.11(n) |
|
BC061938.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC059621.12 |
-- |
72.99(n) |
|
393752 BC059621.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG116613
Nc73EF1 |
oxoglutarate dehydrogenase (lipoamide)3
Neural conserved at 73EF1 |
61(a)
(best of 3)3
62.44(n)1
63.05(a)1 |
|
73E13
398991 NM_176342.31 NP_788520.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
T22B11.53
ogdh-11 |
2-oxoglutarate dehydrogenase3
Protein OGDH-11 |
57(a)3
58.06(n)1
59.21(a)1 |
|
IV(4697518-4704180)3
1772351 NM_068216.31 NP_500617.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
KGD1(YIL125W)4
KGD11 |
Component of the mitochondrial alpha-ketoglutarate more4
Kgd1p1 |
51.63(n)1
48.48(a)1 |
|
9(122689-125733)4
8546811, 4 NP_012141.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G657501 |
2-oxoglutarate dehydrogenase, E1 component |
55(n)
52.76(a) |
|
836704 NM_125972.4 NP_201376.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.118722 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.01(n) |
|
AK067777.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
sucA6 |
2-oxoglutarate decarboxylase, thiamin-requiring |
39(a) |
1 → many |
Chromosome(757929-760730) |
ENSEMBL Gene Tree for OGDH (if available)
TreeFam Gene Tree for OGDH (if available) |
Paralogs
for OGDH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OGDH gene
- DHTKD12 OGDHL2
2 SIMAP similar genes for OGDH using alignment to 10 protein entries: ODO1_HUMAN (see all proteins):OGDHL DHTKD1
OGDH for paralogs About GeneDecksing
|
Genomic Variants
for OGDH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OGDH (44646121 - 44748669 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OGDH
1 CNV: 59412 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for OGDH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OGDH for disorders About GeneDecksing
OMIM gene information: 613022
OMIM disorders: 203740
20/36  diseases for OGDH (see all 36): About MalaCardsalpha-ketoglutarate dehydrogenase deficiency maple syrup urine disease wernicke-korsakoff syndrome hypotonia
wernicke encephalopathy congestive heart failure lactic acidosis primary biliary cirrhosis
friedreich ataxia spinocerebellar ataxia refsum disease neurodegenerative disease
rett syndrome respiratory failure myocardial infarction parkinson's disease
diabetes mellitus fanconi syndrome alzheimer's disease neurodegeneration
10/16 Novoseek disease relationships for OGDH gene (see all 16) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| door syndrome |
74.1 |
1 |
17343268 (1) |
| biliary cirrhosis primary |
71.8 |
12 |
2188870 (2), 9089910 (1), 1380527 (1), 10385636 (1) (see all 11) |
| thiamine deficiency |
70.2 |
3 |
8683340 (1), 19067139 (1) |
| korsakoff syndrome |
53.9 |
1 |
8279670 (1) |
| alzheimers disease |
36.2 |
3 |
8619544 (1), 2087217 (1), 15663478 (1) |
| neurodegenerative diseases |
35.5 |
3 |
19087395 (1), 15840571 (1), 15663478 (1) |
| neurodegeneration |
34 |
2 |
18783430 (1) |
| parkinson disease |
24.6 |
3 |
8986127 (1), 19087395 (1), 12963742 (1) |
| autoimmune response |
14.1 |
3 |
8527402 (1) |
| mimicry |
12.6 |
1 |
7548757 (1) |
Genatlas disease: OGDH congenital lactic acidosis with hypotonia and progressive neurologic deterioration leading to early death
Human Genome Epidemiology (HuGE) Navigator: OGDH (1 document)
Export disorders for OGDH gene to outside databases
|
Publications
for OGDH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OGDH gene, integrated from 9 sources (see all 224):
(articles sorted by number of sources associating them with OGDH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and nucleotide sequence of the cDNA encoding human 2- oxoglutarate dehydrogenase (lipoamide). (PubMed id 1542694)1, 2, 3, 9 Koike K.... Goto S. (1992)
- Localization of the gene (OGDH) coding for the E1k component of the alpha-ketoglutarate dehydrogenase complex to chromosome 7p13-p11.2. (PubMed id 8020988)1, 3, 9 Szabo P....Blass J.P. (1994)
- The gene encoding human 2-oxoglutarate dehydrogenase: structural organization and mapping to chromosome 7p13-p14. (PubMed id 7622061)1, 2, 9 Koike K. (1995)
- Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. (PubMed id 15649899)1, 9 Shi Q....Gibson G.E. (2005)
- The tricarboxylic acid cycle, an ancient metabolic network with a novel twist. (PubMed id 17668068)7, 9 Mailloux R.J....Appanna V.D. (2007)
- Exclusion of OGDH and BMP4 as candidate genes in two siblings with autosomal recessive DOOR syndrome. (PubMed id 17343268)1, 9 van Bever Y....Courtens W. (2007)
- Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah. (PubMed id 15466852)1, 9 Habelhah H....Ronai Z. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Deficits in the mitochondrial enzyme a-ketoglutarate d ehydrogenase lead to Alzheimer's disease-like calcium dysregulation. (PubMed id 22169199)1 Gibson G.E....Shi Q. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for OGDH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OGDH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OGDH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OGDH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OGDH | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Alpha-ketoglutarate_dehydrogenase |
|
| | |
About This Section
| Patent Information for OGDH gene:
Search GeneIP for patents involving OGDH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OGDH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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