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ODZ4 Gene

protein-coding GIFtS: 46

GC11M078041

odz, odd Oz/ten-m homolog 4 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Doc4 ^²
FLJ99165 ^²
KIAA1302 ^¹, ³
TNM4 ^², ³
Ten-4 ^³
Ten-M4 ^¹, ²
Ten-m4 ^³
Tenascin-M4 ^³

Descriptions
Protein Odd Oz/ten-m homolog 4 ^³
odd Oz/ten-m homolog 4 ^²
odz, odd Oz/ten-m homolog 4 ^²
odz, odd Oz/ten-m homolog 4 (Drosophila) ^²

External Ids
HGNC: 29945¹
Entrez Gene: 26011²
UniProtKB: Q6N022³
Ensembl: ENSG00000149256⁷

Search outside databases for aliases for ODZ4 gene

Previous GC identifers: GC11M078588 GC11M078095

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: TEN4_HUMAN, Q6N022

Function: May function as a cellular signal transducer

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ODZ4 gene

Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q13

ODZ4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M078041: (about GC identifiers)

Start:	78,041,976 bp from pter
End:	78,458,637 bp from pter
Size:	416,662 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033927.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TEN4_HUMAN, Q6N022 (See protein sequence)

Recommended Name: Teneurin-4

Size: 2769 amino acids; 307957 Da

Subunit: Homodimer; disulfide-linked (Probable)

Subcellular location: Membrane; Single-pass type II membrane protein (Probable)

Secondary accessions: A6ND26 Q7Z3C7 Q96MS6 Q9P2P4 Q9Y4S2

REFSEQ proteins: NP_001092286.2

ENSEMBL proteins:

ENSP00000278550

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for ODZ4:

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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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	Search Novus for antibodies for ODZ4

Assays for ODZ4:

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	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q6N022

ProtoNet protein and cluster: Q6N022

UniProtKB/Swiss-Prot: TEN4_HUMAN, Q6N022

Domain: EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation

of intermolecular disulfide bonds

Domain: Cytoplasmic proline-rich regions could serve as docking domains for intracellular

SH3-containing proteins

Similarity: Belongs to the tenascin family. Teneurin subfamily

Similarity: Contains 8 EGF-like domains

Similarity: Contains 5 NHL repeats

Similarity: Contains 1 teneurin N-terminal domain

Similarity: Contains 23 YD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ODZ4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Applied Biosystems Silencer® siRNAs for ODZ4

Sigma-Aldrich siRNA for ODZ4

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001098816
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001098816
untagged cDNA clone in CMV expression vector: NM_001098816

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001098816

UniProtKB/Swiss-Prot: TEN4_HUMAN, Q6N022

Function: May function as a cellular signal transducer

8 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Odz4):

	embryogenesis	growth/size	lethality-prenatal/perinatal	life span-post-weaning/aging
limbs/digits/tail	nervous system	skeleton

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001702	gastrulation with mouth forming second	IEA	--
GO:0007165	signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ODZ4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ODZ4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Sigma-Aldrich siRNA for ODZ4

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001098816

REFSEQ mRNAs for ODZ4 gene:

NM_001098816.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001098816

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001098816
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001098816
                                 untagged cDNA clone in CMV expression vector: NM_001098816

Additional cDNA sequence:

AB037723.3 AK023935.1 AK056531.1 AK127101.1 AK127705.1 AL080120.1 BX537983.1 BX640737.1

5 DOTS entries:

DT.413074 DT.92430139 DT.91881147 DT.99930247 DT.75123512

1 AceView cDNA sequence:

BE671538

highest scoring ESTs for ODZ4:

AL080120 AA449490 AA449657 AA478963 AA480010 AA665632 AA678541 AA774614 AA923700 AA934501

Unigene Cluster for ODZ4:

Odz, odd Oz/ten-m homolog 4 (Drosophila)

Hs.213087 [show with all ESTs]

Unigene Representative Sequence: NM_001098816

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ODZ4

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c
SP1:
SP2:													-		-

About this scheme

ECgene alternative splicing isoforms for ODZ4

1 Ensembl transcript including schematic representation:

ENST00000278550

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ODZ4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ODZ4

¹ / ² / ³

3 probe-sets matching ODZ4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36078_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AL080120	0.80	1.00	0.91	1
213273_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF112171	0.60	1.00	0.82	1
213273_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ODZ4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.213087
Expression variation in blood from EXPOLDB for ODZ4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ODZ4 gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
mouse (Mus musculus)	Odz4⁵	7 (47.70 cM)	odd Oz/ten-m homolog 4 (Drosophila)	--	R75022
zebrafish (Danio rerio)	odz4²	--	odd Oz/ten-m homolog 4	76.51(n)	30156 AB026980.1

About this table Species with no ortholog for ODZ4

ENSEMBL Gene Tree for ODZ4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ODZ4 gene

ODZ1² ODZ3² ODZ2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/784 NCBI SNPs in ODZ4 are shown (see all 784 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 215)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs671307^1,2	A,C,F,H,O	78201893(+)	`AATAAG/ACAGAC`	1	--	ng3¹		11	EU EA WA	1192
--	rs1792131^1,2	A,C,F,H,O	78042618(+)	`AATGTA/GAAGGT`	1	--	ut3¹		13	MN EU EA WA NA	1336
--	rs6592834^1,2	A,C,F,H	78604524(+)	`GTTCTG/AAAGAG`	1	--	ut5¹		17	EU EA WA NS NA	1266
--	rs3571^1,2	A,C,F,H	78042161(+)	`AAATTA/GGTTCC`	1	--	ut3¹		15	MN EA NA EU WA	1604
	rs522714^1,2	A,C,F,H	78202675(+)	`TCAACT/GTTTTA`	1	--	ng3¹		8	EU EA WA	838
--	rs1792133^1,2	C,F,H	78044234(+)	`AAAAAG/TAAATG`	1	--	ut3¹		5	MN EU EA WA	584
--	rs1122824^1,2	C,F,H	78042880(+)	`GTCCCT/CGGGCC`	1	--	ut3¹ ese³		5	EU EA WA MN	592
	rs17137261^1,2	C,F,H	78242962(+)	`CGCCTC/GCTGGG`	1	E/Q	mis¹		10	NA EA WA EU	812
--	rs12270560^1,2	C,F,H	78044896(+)	`GTGTAA/GTATTC`	1	--	ut3¹ ese³		4	EU EA WA	420
--	rs12280416^1,2	C,F,H	78458696(+)	`GGGCCG/TAGTGG`	1	--	ut5¹		8	EU EA WA	832

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HapMap Linkage Disequilibrium images for ODZ4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610084

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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8 PubMed articles for ODZ4 gene:

Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)^{3, 4} Taylor T.D....Sakaki Y. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
All four members of the Ten-m/Odz family of transmembrane proteins form dimers. (PubMed id 12000766)^{2, 3} Feng K....Fassler R. (2002)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{3, 4} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{3, 4} Nagase T....Ohara O. (2000)
The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles. (PubMed id 10625539)^{2, 3} Ben-Zur T....Wides R. (2000)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Translocation and coamplification of loci from chromosome arms 8p and 11q in the MDA-MB-175 mammary carcinoma cell line. (PubMed id 10717235)¹ Adelaide J....Birnbaum D. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 26011	HGNC: 29945	AceView: ODZ4.2	Ensembl:ENSG00000149256	euGenes: HUgn26011
ECgene: ODZ4	H-InvDB: ODZ4

(According to HUGE)
About This Section

HUGE: KIAA1302

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ODZ4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ODZ4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ODZ4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ODZ4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ODZ4		Browse antibodies at Sigma-Aldrich
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	Recombinant & Natural Proteins

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ODZ4 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for ODZ4

Summaries
for ODZ4

Genomic Location
for ODZ4

Proteins
for ODZ4

Protein Domains/
Families
for ODZ4

Gene Function
for ODZ4

Pathways & Interactions
for ODZ4

Drugs & Compounds
for ODZ4

Transcripts
for ODZ4

Expression
for ODZ4

Orthologs
for ODZ4

Paralogs
for ODZ4

SNPs/Variants
for ODZ4

Disorders & Mutations
for ODZ4

Medical News
for ODZ4

Publications
for ODZ4

Search for ODZ4

Genome Databases showing ODZ4

Other Databases showing ODZ4

Specialized Databases showing ODZ4

Licensable Technologies
for ODZ4

Services
for ODZ4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ODZ4 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor ODZ4

Summariesfor ODZ4

Genomic Locationfor ODZ4

Proteinsfor ODZ4

Protein Domains/Familiesfor ODZ4

Gene Functionfor ODZ4

Pathways & Interactionsfor ODZ4

Drugs & Compoundsfor ODZ4

Transcriptsfor ODZ4

Expression for ODZ4

Orthologsfor ODZ4

Paralogsfor ODZ4

SNPs/Variantsfor ODZ4

Disorders & Mutationsfor ODZ4

Medical Newsfor ODZ4

Publicationsfor ODZ4

Search for ODZ4

Genome Databases showing ODZ4

Other Databases showing ODZ4

Specialized Databases showing ODZ4

Licensable Technologiesfor ODZ4

Servicesfor ODZ4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ODZ4

Summaries
for ODZ4

Genomic Location
for ODZ4

Proteins
for ODZ4

Protein Domains/
Families
for ODZ4

Gene Function
for ODZ4

Pathways & Interactions
for ODZ4

Drugs & Compounds
for ODZ4

Transcripts
for ODZ4

Expression
for ODZ4

Orthologs
for ODZ4

Paralogs
for ODZ4

SNPs/Variants
for ODZ4

Disorders & Mutations
for ODZ4

Medical News
for ODZ4

Publications
for ODZ4

Licensable Technologies
for ODZ4

Services
for ODZ4