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ODZ3 Gene

protein-coding   GIFtS: 47

GC04P183482
odz, odd Oz/ten-m homolog 3 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ10474 2
FLJ10886 2
KIAA1455 1, 2, 3
TNM3 2, 3
Ten-3 3
Ten-M3 1
Ten-m3 2, 3
Tenascin-M3 3
Descriptions
ODZ3-like protein 2
Protein Odd Oz/ten-m homolog 3 3
odd Oz/Ten-m homolog 3 2
odz, odd Oz/ten-m homolog 3 2
odz, odd Oz/ten-m homolog 3 (Drosophila) 2
External Ids
HGNC: 299441
Entrez Gene: 557142
UniProtKB: Q9P2733
Ensembl: ENSG000002183367
Search outside databases for aliases for ODZ3 gene

Previous GC identifers: GC04P184234 GC04P184346 GC04P184212 GC04P183744

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: TEN3_HUMAN, Q9P273
Function: May function as a cellular signal transducer

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ODZ3 gene  

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35

ODZ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P183482:     (about GC identifiers)

Start:
183,482,131 bp from pter
End:
183,961,171 bp from pter
Size:
479,041 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000004.10  NT_022792.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TEN3_HUMAN, Q9P273 (See protein sequence)
Recommended Name: Teneurin-3  
Size: 2699 amino acids; 300950 Da
Subunit: Homodimer; disulfide-linked (Probable)
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: Q5XUL9 Q96SY2 Q9NV77 Q9NVW1 Q9NZJ2

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001073946.1  

    ENSEMBL proteins: 
    ENSP00000385276 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ODZ3)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for ODZ3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ODZ3), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for ODZ3

    Assays for ODZ3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/8 InterPro domains/families (see all 8 ):
     IPR000742 EGF_3
     IPR011042 6-blade_b-propeller_TolB-like
     IPR013032 EGF-like_reg_CS
     IPR009471 Ten_N
     IPR006530 YD


       GeneDecks  ODZ3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9P273

    ProtoNet protein and cluster: Q9P273

    1 Blocks protein family: IPB011070 Globular protein

    UniProtKB/Swiss-Prot: TEN3_HUMAN, Q9P273
    Domain: EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation
    of intermolecular disulfide bonds
    Domain: Cytoplasmic proline-rich regions could serve as docking domains for intracellular
    SH3-containing proteins
    Similarity: Belongs to the tenascin family. Teneurin subfamily
    Similarity: Contains 8 EGF-like domains
    Similarity: Contains 5 NHL repeats
    Similarity: Contains 1 teneurin N-terminal domain
    Similarity: Contains 23 YD repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ODZ3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): XM_497983

                  Applied Biosystems Silencer® siRNAs for ODZ3

                  Sigma-Aldrich siRNA for ODZ3  
                         Sigma-Aldrich shRNA for ODZ3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001080477
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001080477
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001080477 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001080477

    UniProtKB/Swiss-Prot: TEN3_HUMAN, Q9P273
    Function: May function as a cellular signal transducer

    Genatlas biochemistry entry for ODZ3:
    odd oz3 tenascin M (TNM),a late acting Drosophila pair-rule gene homolog

    3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Odz3):

    behavior/neurologicallife span-post-weaning/agingnervous system

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for ODZ3 (Q9P2732) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134852MINT-61956
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ODZ3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ODZ3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): XM_497983

                  Sigma-Aldrich siRNA for ODZ3  
                         Sigma-Aldrich shRNA for ODZ3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001080477  

    REFSEQ mRNAs for ODZ3 gene: 

    NM_001080477.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001080477  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001080477
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001080477
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001080477 

    Additional cDNA sequence: 

    AB040888.2 AF195420.1 AK001336.1 AK001748.1 AK027473.1 AK125869.1 AK308489.1 AY726602.1 

    9 DOTS entries:

    DT.414355  DT.91653058  DT.40205558  DT.91692138  DT.121272674  DT.102829045  DT.97763390  DT.75106953 
    DT.95260704 

    24/92 AceView cDNA sequences (see all 92 ):

    AU133387 AU119743 CA454304 AB040888 BM670316 AI080208 AK001748 BE382393 
    Z40842 AK125869 AU124680 AK027473 AA236806 AK001336 BQ892798 AI820014 
    AU126844 BM931190 AA903519 CB106684 AI191088 AI288227 BM712036 CA777388 

    highest scoring ESTs for ODZ3:

    AA142988 AA149382 AA150978 AA424477 AA449172 AA452858 AA476500 AA903519 AB040888 AI080208 

    Unigene Cluster for ODZ3:

    Odz, odd Oz/ten-m homolog 3 (Drosophila)
    Hs.130438  [show with all ESTs]
    Unigene Representative Sequence: NM_001080477


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000406950  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ODZ3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ODZ3

    1 / 2 / 3

    5 probe-sets matching ODZ3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    46661_at2, 3 U95-B 1 1.00 1.00 0.39 1.58 AA142988 1.00 1.00 1.00 1

    43971_at2, 3 U95-B 1 0.94 1.00 0.96 0.53 AI817178 0.80 1.00 0.91 1

    219523_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018104 0.20 1.00 0.72 1

    1559661_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    219523_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.130438

    UniProtKB/Swiss-Prot: TEN3_HUMAN, Q9P273
    Tissue specificity: Expressed in adult and fetal brain, slightly lower levels in testis and ovary,
    and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or
    liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed
    by thalamus and subthalamic nucleus

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ODZ3 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ODZ11   -- odz, odd Oz/ten-m homolog 1(Drosophila) 91.52(n)
    97.55(a)
    475637  XM_852690.1  XP_857783.1 
    chimpanzee
    (Pan troglodytes)
    ODZ11   -- odz, odd Oz/ten-m homolog 1(Drosophila) 99.3(n)
    99.74(a)
    743345  XM_001160536.1  XP_001160536.1 
    cow
    (Bos taurus)
    ODZ31   -- similar to Teneurin-3 (Ten-3) (Tenascin-M3) (Ten-m3) more 90.64(n)
    98.89(a)
    511615  XM_865074.2  XP_870167.2 
    rat
    (Rattus norvegicus)
    Odz31   -- odz, odd Oz/ten-m homolog 3 (Drosophila) 88.62(n)
    97.91(a)
    306451  XM_224841.4  XP_224841.4 
    mouse
    (Mus musculus)
    Odz31, 5 85
    odd Oz/ten-m homolog 3 (Drosophila)1, 5 88.97(n)1
    98.26(a)1
    239651  NM_011857.21  NP_035987.21 
     AB0254125  AF1954185  (see all 15)
    About this table        Species with no ortholog for ODZ3

    ENSEMBL Gene Tree for ODZ3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ODZ3 gene
    ODZ12  ODZ42  ODZ22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/3125 NCBI SNPs in ODZ3 are shown (see all 3125 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 1082)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs27268221,2
    A,C,F,H,O183481212(-) GGGGCT/GAATCC 1 -- ng514Minor allele frequency- G:0.32EU EA WA 412
    rs23097771,2
    A,C,F,H183959737(-) CTCCTA/GTTTCC 1 -- ut318Minor allele frequency- G:0.39EU EA WA NA 780
    rs42417521,2
    A,C,F,H183958846(+) AATGTG/ATACAG 1 -- ut314Minor allele frequency- A:0.40EU EA WA 412
    rs37495091,2
    C,F,H183831194(+) AGATTC/GCGGAG 1 S/C mis18Minor allele frequency- G:0.00EU EA WA 836
    rs76778111,2
    A,H183960110(+) TTCATC/TGAGCT 1 -- ut314Minor allele frequency- T:0.00EU EA WA 418
    rs119473541,2
    C,F183960011(+) CAGCCG/ACCATC 1 -- ut314Minor allele frequency- A:0.25NA EA 362
    rs68284451,2
    A,C183481863(+) AGATAC/TAGTAG 1 -- ng510--------
    --
    rs76835491,2
    A183960545(+) GTTAGG/TTATTT 1 -- ut310--------
    --
    rs76787951,2
    A183960454(+) CTTTGG/TCAAGT 1 -- ut310--------
    rs48620931,2
    H183933263(+) GCAAGC/TCCAAG 1 A/V mis14Minor allele frequency- T:0.00EU EA WA 416
    About this table

    HapMap Linkage Disequilibrium images for ODZ3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610083

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    7 PubMed articles for ODZ3 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 55714 HGNC: 29944 AceView: ODZ3 Ensembl:ENSG00000218336 euGenes: HUgn55714
    ECgene: ODZ3 H-InvDB: ODZ3
    (According to HUGE)
    About This Section

    HUGE: KIAA1455
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ODZ3 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ODZ3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ODZ3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ODZ3 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ODZ3 Browse small molecules at Sigma-Aldrich
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