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ODZ2 Gene

protein-coding GIFtS: 46

GC05P166646

odz, odd Oz/ten-m homolog 2 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp686A1568 ^²
KIAA1127 ^¹, ³
TEN-M2 ^²
TNM2 ^², ³
Ten-2 ^³
Ten-M2 ^¹
Ten-m2 ^³
Tenascin-M2 ^³

Descriptions
Protein Odd Oz/ten-m homolog 2 ^³
neurestin alpha ^²
odd Oz/ten-m homolog 2 ^²
odz, odd Oz/ten-m homolog 2 ^²
odz, odd Oz/ten-m homolog 2 (Drosophila) ^²
teneurin 2 ^²

External Ids
HGNC: 29943¹
Entrez Gene: 57451²
UniProtKB: Q9NT68³
Ensembl: ENSG00000145934⁷

Search outside databases for aliases for ODZ2 gene

Previous GC identifers: GC05P167551 GC05P168266 GC05P167162 GC05P167221

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TEN2_HUMAN, Q9NT68

Function: May function as a cellular signal transducer

Gene Wiki entry for ODZ2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ODZ2 gene

Entrez Gene cytogenetic band: 5q34-q35.1 Ensembl cytogenetic band: 5q34 HGNC cytogenetic band: 5q35

ODZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P166646: (about GC identifiers)

Start:	166,644,421 bp from pter
End:	167,623,740 bp from pter
Size:	979,320 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_023133.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TEN2_HUMAN, Q9NT68 (See protein sequence)

Recommended Name: Teneurin-2

Size: 2774 amino acids; 307691 Da

Subunit: Homodimer; disulfide-linked (By similarity)

Subcellular location: Membrane; Single-pass type II membrane protein (Probable)

Secondary accessions: Q9ULU2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001073897.2 NP_001116151.1

ENSEMBL proteins:

ENSP00000384905 ENSP00000373555

Human Recombinant Proteins

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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for ODZ2:

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	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ODZ2

Assays for ODZ2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9NT68

ProtoNet protein and cluster: Q9NT68

UniProtKB/Swiss-Prot: TEN2_HUMAN, Q9NT68

Domain: EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation

of intermolecular disulfide bonds

Domain: Cytoplasmic proline-rich regions could serve as docking domains for intracellular

SH3-containing proteins

Similarity: Belongs to the tenascin family. Teneurin subfamily

Similarity: Contains 8 EGF-like domains

Similarity: Contains 5 NHL repeats

Similarity: Contains 1 teneurin N-terminal domain

Similarity: Contains 23 YD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ODZ2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_001122679

Applied Biosystems Silencer® siRNAs for ODZ2

Sigma-Aldrich siRNA for ODZ2

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001080428
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001080428
untagged cDNA clones in CMV expression vector (see all 4): AK056053

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001122679

UniProtKB/Swiss-Prot: TEN2_HUMAN, Q9NT68

Function: May function as a cellular signal transducer

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ODZ2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ODZ2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_001122679

Sigma-Aldrich siRNA for ODZ2

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001122679

REFSEQ mRNAs for ODZ2 gene (2 alternative transcripts):

NM_001080428.2 NM_001122679.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001122679

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001080428
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001080428
                                 untagged cDNA clones in CMV expression vector (see all 4): AK056053

Additional cDNA sequence: AK293262.1

5 DOTS entries:

DT.434490 DT.101978854 DT.100659003 DT.95210375 DT.100023662

9 AceView cDNA sequences:

BX953759 AK056053 AL710285 AL598057 AL710528 AL710634 BM017187 BX648178

BF363040

highest scoring ESTs for ODZ2:

AI859144 AA334973 AA446367 AB032953 AI492934 AI692521 AL137500 AW069752 AW139310 AW419319

Unigene Clusters for ODZ2:

Odz, odd Oz/ten-m homolog 2 (Drosophila)

Hs.654631 [show with all ESTs], Hs.715483

Unigene Representative Sequences: NM_001122679, AK293262

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ODZ2

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18
SP1:					-
SP2:

About this scheme

ECgene alternative splicing isoforms for ODZ2

2 Ensembl transcripts including schematic representations:

ENST00000403607 ENST00000388903

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ODZ2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ODZ2

¹ / ² / ³

3 probe-sets matching ODZ2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
77546_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AI859144	1.00	1.00	1.00	1
231867_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB032953	0.80	1.00	0.91	1
231867_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ODZ2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.654631 Hs.715483
UniProtKB/Swiss-Prot: TEN2_HUMAN, Q9NT68
Tissue specificity: Highly expressed in heart, followed by brain, liver, kidney and fetal brain and
weakly expressed in lung and testis. No expression was detected in skeletal muscle, pancreas,
spleen, ovary and fetal liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ODZ2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ODZ2¹	--	odz, odd Oz/ten-m homolog 2 (Drosophila)	93.11(n) 99.19(a)	489135 XM_546253.2 XP_546253.2
rat (Rattus norvegicus)	Odz2¹	--	odz, odd Oz/ten-m homolog 2 (Drosophila)	89.79(n) 98.27(a)	117242 NM_020088.1 NP_064473.1
mouse (Mus musculus)	Odz2^{1, 5}	11 (18.00 cM)⁵	odd Oz/ten-m homolog 2 (Drosophila)^{1, 5}	90.19(n)¹ 98.59(a)¹	23964¹ NM_011856.2¹ NP_035986.2¹ AB025411⁵ AF195419⁵ (see all 18)
chicken (Gallus gallus)	ODZ2¹	--	odz, odd Oz/ten-m homolog 2 (Drosophila)	80.76(n) 94.54(a)	373854 NM_204097.2 NP_989428.2
zebrafish (Danio rerio)	LOC563197¹	--	similar to Teneurin-2 (Ten-2) (Tenascin-M2) (Ten-m2) more	71.94(n) 79.51(a)	563197 XM_686559.3 XP_691651.3

About this table Species with no ortholog for ODZ2

ENSEMBL Gene Tree for ODZ2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ODZ2 gene

ODZ1² ODZ3² ODZ4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2756 NCBI SNPs in ODZ2 are shown (see all 2756 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1676)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6866651^1,2	A,C,F,H	167113916(+)	`TAACCG/AACCAG`	1	--	ng5¹		4	EU EA WA	402
	rs11750265^1,2	A,C,F,H	167623786(+)	`CAAGCG/ATTACT`	1	--	ng3¹		15	EU EA WA NA	1400
	rs1862875^1,2	A,F,H	167114633(-)	`ATCGGT/CGTAAG`	1	--	ut5¹		5	MN EU EA WA	602
	rs3733989^1,2	C,F,H	167622795(+)	`GGACCA/GATAAA`	1	--	ut3¹ ese³		13	EA NA EU WA	2550
	rs6862925^1,2	C,F,H	167484607(+)	`TCCCAA/GCTGGA`	1	N/S	mis¹ ese³		8	EU EA WA	838
	rs4869070^1,2	F,H	167114117(+)	`ATAAGG/CGTTTT`	1	--	ng5¹		4	EU EA WA	416
	rs17069140^1,2	F,H	167114084(+)	`CATCCG/ATCAAC`	1	--	ng5¹		7	NA EU EA WA	534
--	rs12519612^1,2	C,H	167585804(+)	`TCATCA/CCCAAC`	1	T/P	mis¹		4	EU EA WA	404
	rs11957063^1,2	C,H	167574759(+)	`CGGAAG/TTTGTG`	1	V/F	mis¹ ese³		5	EU EA WA NA	510
	rs3749800^1,2	F,H	167113644(+)	`CTACAC/TTATGA`	1	--	ng5¹		5	EA EU WA	1890

About this table

HapMap Linkage Disequilibrium images for ODZ2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610119

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/13 PubMed articles for ODZ2 gene (see all 13 ):

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)^{3, 4} Schmutz J.... Rubin E.M. (2004)
The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles. (PubMed id 10625539)^{2, 3} Ben-Zur T....Wides R. (2000)
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)^{3, 4} Hirosawa M....Ohara O. (1999)
The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription. (PubMed id 12783990)^{1, 3} Bagutti C....Chiquet-Ehrismann R. (2003)
Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3. (PubMed id 18927281)³ Vinatzer U....Streubel B. (2008)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. (PubMed id 17053785)⁴ Wang Y.... Chen Z. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)³ Dias Neto E....Simpson A.J.G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57451	HGNC: 29943	AceView: ODZ2	Ensembl:ENSG00000145934	euGenes: HUgn57451
ECgene: ODZ2	H-InvDB: ODZ2

(According to HUGE)
About This Section

HUGE: KIAA1127

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ODZ2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ODZ2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ODZ2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ODZ2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
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	Recombinant & Natural Proteins

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ODZ2 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for ODZ2

Summaries
for ODZ2

Genomic Location
for ODZ2

Proteins
for ODZ2

Protein Domains/
Families
for ODZ2

Gene Function
for ODZ2

Pathways & Interactions
for ODZ2

Drugs & Compounds
for ODZ2

Transcripts
for ODZ2

Expression
for ODZ2

Orthologs
for ODZ2

Paralogs
for ODZ2

SNPs/Variants
for ODZ2

Disorders & Mutations
for ODZ2

Medical News
for ODZ2

Publications
for ODZ2

Search for ODZ2

Genome Databases showing ODZ2

Other Databases showing ODZ2

Specialized Databases showing ODZ2

Licensable Technologies
for ODZ2

Services
for ODZ2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ODZ2 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor ODZ2

Summariesfor ODZ2

Genomic Locationfor ODZ2

Proteinsfor ODZ2

Protein Domains/Familiesfor ODZ2

Gene Functionfor ODZ2

Pathways & Interactionsfor ODZ2

Drugs & Compoundsfor ODZ2

Transcriptsfor ODZ2

Expression for ODZ2

Orthologsfor ODZ2

Paralogsfor ODZ2

SNPs/Variantsfor ODZ2

Disorders & Mutationsfor ODZ2

Medical Newsfor ODZ2

Publicationsfor ODZ2

Search for ODZ2

Genome Databases showing ODZ2

Other Databases showing ODZ2

Specialized Databases showing ODZ2

Licensable Technologiesfor ODZ2

Servicesfor ODZ2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ODZ2

Summaries
for ODZ2

Genomic Location
for ODZ2

Proteins
for ODZ2

Protein Domains/
Families
for ODZ2

Gene Function
for ODZ2

Pathways & Interactions
for ODZ2

Drugs & Compounds
for ODZ2

Transcripts
for ODZ2

Expression
for ODZ2

Orthologs
for ODZ2

Paralogs
for ODZ2

SNPs/Variants
for ODZ2

Disorders & Mutations
for ODZ2

Medical News
for ODZ2

Publications
for ODZ2

Licensable Technologies
for ODZ2

Services
for ODZ2