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ODZ1 Gene

protein-coding   GIFtS: 49

GC0XM123339
odz, odd Oz/ten-m homolog 1(Drosophila)
(Previous name: tenascin M )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ODZ3, TNM)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
ODZ3 2
OTTHUMP00000024333 2
OTTHUMP00000062724 2
TEN-M1 1, 2
TNM 2
TNM1 2, 3
Ten-1 3
Ten-m1 3
Tenascin-M1 3
teneurin-1 2
Descriptions
Protein Odd Oz/ten-m homolog 1 3
odz (odd Oz/ten-m, Drosophila) homolog 1 2
odz (odd Oz/ten-m, Drosophila) homolog 3 2
odz, odd Oz/ten-m homolog 1 2
odz, odd Oz/ten-m homolog 1(Drosophila) 2
tenascin M 1, 2
External Ids
HGNC: 81171
Entrez Gene: 101782
UniProtKB: Q9UKZ43
Ensembl: ENSG000000096947
Search outside databases for aliases for ODZ1 gene

Previous GC identifers: GC0XM118232 GC0XM120407 GC0XM121466 GC0XM122212 GC0XM123239

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: TEN1_HUMAN, Q9UKZ4
Function: May function as a cellular signal transducer

Gene Wiki entry for ODZ1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ODZ1 gene  

Entrez Gene cytogenetic band: Xq25   Ensembl cytogenetic band:  Xq25   HGNC cytogenetic band: Xq25

ODZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM123339:     (about GC identifiers)

Start:
123,339,504 bp from pter
End:
123,925,347 bp from pter
Size:
585,844 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011786.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TEN1_HUMAN, Q9UKZ4 (See protein sequence)
Recommended Name: Teneurin-1  
Size: 2725 amino acids; 305011 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: Q5JZ17

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_055068.2  

    ENSEMBL proteins: 
    ENSP00000360171 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ODZ1)
    Human Recombinant Proteins from Abnova (ODZ1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region TAS10341219
    GO:0005887 integral to plasma membrane IEA--
    GO:0016020 membrane IEA--
    About this table

    Antibodies for ODZ1: 
    Browse Antibodies Central at Invitrogen
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    Sigma-Aldrich Antibodies for ODZ1
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    Antibodies from Abcam (ODZ1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ODZ1)
    Novus Biologicals Antibodies for ODZ1

    Assays for ODZ1: 
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    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/9 InterPro domains/families (see all 9 ):
     IPR000742 EGF_3
     IPR011042 6-blade_b-propeller_TolB-like
     IPR013032 EGF-like_reg_CS
     IPR009471 Ten_N
     IPR006530 YD


       GeneDecks  ODZ1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UKZ4

    ProtoNet protein and cluster: Q9UKZ4

    UniProtKB/Swiss-Prot: TEN1_HUMAN, Q9UKZ4
    Domain: EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation
    of intermolecular disulfide bonds
    Domain: Cytoplasmic proline-rich regions could serve as docking domains for intracellular
    SH3-containing proteins
    Similarity: Belongs to the tenascin family. Teneurin subfamily
    Similarity: Contains 8 EGF-like domains
    Similarity: Contains 5 NHL repeats
    Similarity: Contains 1 teneurin N-terminal domain
    Similarity: Contains 23 YD repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ODZ1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ODZ1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014253

                  Applied Biosystems Silencer® siRNAs for ODZ1

                  Sigma-Aldrich siRNA and siRNA Panels for ODZ1  
                         Sigma-Aldrich shRNA for ODZ1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014253
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014253
                                     untagged cDNA clone in CMV expression vector: NM_014253 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_014253

    UniProtKB/Swiss-Prot: TEN1_HUMAN, Q9UKZ4
    Function: May function as a cellular signal transducer

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008201 heparin binding TAS10341219
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  ODZ1 

      --

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955 immune response TAS10556288
    GO:0007165 signal transduction IEA--
    GO:0007399 nervous system development TAS10341219
    GO:0008285 negative regulation of cell proliferation TAS10556288
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ODZ1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ODZ1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ODZ1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014253

                  Sigma-Aldrich siRNA and siRNA Panels for ODZ1  
                         Sigma-Aldrich shRNA for ODZ1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_014253  

    REFSEQ mRNAs for ODZ1 gene: 

    NM_014253.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_014253  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014253
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014253
                                     untagged cDNA clone in CMV expression vector: NM_014253 

    Additional cDNA sequence: 

    AF100772.1 BC140783.1 BC144542.1 BC144543.1 

    4 DOTS entries:

    DT.91785063  DT.100847364  DT.95174592  DT.95106234 

    24/48 AceView cDNA sequences (see all 48 ):

    AI016320 BX506934 BX478232 AI498402 AL602335 AA235370 AA323193 AA331486 
    AW779760 AK055765 NM_014253 BX457474 AW296554 BI918168 CF454574 BX470621 
    BE168542 AF100772 BX494675 AL039060 BC030766 BG699146 BX108936 BX951531 

    highest scoring ESTs for ODZ1:

    AF100772 AL039060 AV708814 AW863569 BE088769 BE161640 BE161779 BE168542 BE700315 BX470621 

    Unigene Clusters for ODZ1:

    Odz, odd Oz/ten-m homolog 1(Drosophila)
    Hs.23796  [show with all ESTs], Hs.716649  [show with all ESTs]
    Unigene Representative Sequences: AK055765, NM_014253


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000371130  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ODZ1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ODZ1

    1 / 2 / 3

    1 probe-set matching ODZ1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    1553007_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGGAACTCAT

    SOURCE GeneReport for Unigene clusters: Hs.23796 Hs.716649

    UniProtKB/Swiss-Prot: TEN1_HUMAN, Q9UKZ4
    Tissue specificity: Expressed in fetal brain

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ODZ1 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ODZ11   -- odz, odd Oz/ten-m homolog 1(Drosophila) 93.99(n)
    98.42(a)
    612901  XM_860042.1  XP_865135.1 
    mouse
    (Mus musculus)
    Odz11, 5 X5
    odd Oz/ten-m homolog 1 (Drosophila)1, 5 91.31(n)1
    96.99(a)1
    239631  NM_011855.31  NP_035985.21 
     AB0254105  AK0378975  (see all 11)
    chicken
    (Gallus gallus)
    ODZ11   -- odz, odd Oz/ten-m homolog 1(Drosophila) 80.17(n)
    89.88(a)
    395668  NM_204862.1  NP_990193.1 
    zebrafish
    (Danio rerio)
    CH211-1C4.11   -- novel protein similar to vertebrate odz, odd Oz/ten-m more 64.57(n)
    67.17(a)
    563094  XM_686460.3  XP_691552.3 
    fruit fly
    (Drosophila melanogaster)
    Ten-a3 11A7--8 cell adhesion cell adhesion molecule 43(a)
    (best of 2)
      --
    About this table        Species with no ortholog for ODZ1

    ENSEMBL Gene Tree for ODZ1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ODZ1 gene
    ODZ32  ODZ42  ODZ22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1707 NCBI SNPs in ODZ1 are shown (see all 1707 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 549)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs66485971,2
    A,C,F,H123341687(+) AGCCCA/GTAAGT 1 -- ut31 ese315Minor allele frequency- N:0.00EU EA WA NA 1067
    rs22135911,2
    A,C,F,H123633270(-) GTCCAT/CGGACA 1 T/M mis1 ese39Minor allele frequency- C:0.07NA EU EA WA 712
    rs59586351,2
    A,C,F,H123925440(+) AATACC/TATCAA 1 -- ng31 tfbs34Minor allele frequency- T:0.15EU EA WA 418
    rs22353811,2
    A,C,F,H123339464(+) CTCCAT/CCTTCT 1 -- ng51 trp34Minor allele frequency- C:0.26EU EA WA 416
    rs59567171,2
    A,C,F,H123926926(+) TTTTTA/TAAAAA 1 -- ng315Minor allele frequency- T:0.42EU WA NA 382
    rs169993341,2
    C,F,H123603505(+) ACACAT/CTGGGT 1 V/M mis111Minor allele frequency- C:0.06NA EU EA WA 732
    rs59584761,2
    C,F,H123340785(+) GTAAGG/TACGGA 1 -- ut31 ese34Minor allele frequency- T:0.01EU EA WA 414
    rs66492711,2
    C,F,H123603478(+) TCCTTT/CTACAC 1 E/K mis1 trp34Minor allele frequency- C:0.00EU EA WA 418
    rs360651911,2
    C,F123925166(-) AGTCAT/CACAAC 1 H/Y mis15Minor allele frequency- C:0.13NA EU EA WA 319
    --
    rs102840391,2
    C,F123926284(+) GTCATC/TACCAT 1 -- ng313Minor allele frequency- T:0.01NA 142
    About this table

    HapMap Linkage Disequilibrium images for ODZ1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 300588

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/15 PubMed articles for ODZ1 gene (see all 15 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 10178 HGNC: 8117 AceView: ODZ1 Ensembl:ENSG00000009694 euGenes: HUgn10178
    ECgene: ODZ1 H-InvDB: ODZ1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ODZ1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for ODZ1 Antibodies for ODZ1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ODZ1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for ODZ1

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