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Aliases for ODR4 Gene

Aliases for ODR4 Gene

  • Odr-4 GPCR Localization Factor Homolog 2 3
  • LAG1-Interacting Protein 2 3 4
  • C1orf27 3 4 5
  • Transactivated By Recombinant Transforming Growth Factor Beta 1 2 3
  • Transactivated By Transforming Growth Factor Beta Protein 1 3 4
  • Chromosome 1 Open Reading Frame 27 2 5
  • TTG1 3 4
  • Transactivated By Recombinant Transforming Growth Factor Beta 3
  • Odorant Response Abnormal 4 3
  • Protein Odr-4 Homolog 3
  • HODR-4 4
  • Odr-4 3
  • TTG1A 4

External Ids for ODR4 Gene

Previous HGNC Symbols for ODR4 Gene

  • C1orf27

Summaries for ODR4 Gene

GeneCards Summary for ODR4 Gene

ODR4 (Odr-4 GPCR Localization Factor Homolog) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ODR4 Gene

  • May play a role in the trafficking of a subset of G-protein coupled receptors.

Additional gene information for ODR4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODR4 Gene

Genomics for ODR4 Gene

GeneHancer (GH) Regulatory Elements for ODR4 Gene

Promoters and enhancers for ODR4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I186373 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 558.2 -0.4 -409 3.7 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 TPR ODR4 OCLM ENSG00000228238 GC01P186372 GC01M186369
GH01I186848 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl 22.6 +473.7 473654 1.8 FOXA2 ZSCAN4 BATF IRF4 RELA NFATC1 FOSL2 FOS IKZF2 RUNX3 PLA2G4A ODR4 ENSG00000228238 PTGS2 GC01P187071
GH01I185438 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.6 -934.6 -934600 4.6 PKNOX1 ATF1 SIN3A GLIS2 ATF7 FOS SP3 TSHZ1 ZNF623 GLIS1 IVNS1ABP ODR4 SWT1 RNF2 MCRIP2P2 ENSG00000279401
GH01I186081 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.3 -293.0 -292991 2 PKNOX1 FOXA2 SMAD1 ARNT FEZF1 IRF4 ZNF766 CBX5 E2F8 SP3 OCLM TPR ODR4 HMCN1 PDC ENSG00000224691 GC01M185927
GH01I185374 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.3 -999.5 -999549 3.1 PKNOX1 STAT1 ZNF740 ETV1 TSC22D4 DPF2 ZNF354B GABPA ZNF395 BCL11A IVNS1ABP EDEM3 TPR RNU7-183P ODR4 FAM129A SWT1 LOC100422414 RNF2 TRMT1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ODR4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ODR4 Gene

Genomic Locations for ODR4 Gene
45,621 bases
Plus strand

Genomic View for ODR4 Gene

Genes around ODR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODR4 Gene

Proteins for ODR4 Gene

  • Protein details for ODR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein odr-4 homolog
    Protein Accession:
    Secondary Accessions:
    • B4DNY0
    • E9PFR7
    • Q19CC6
    • Q8WYB6
    • Q9BTS2
    • Q9H6A6
    • Q9NX06

    Protein attributes for ODR4 Gene

    454 amino acids
    Molecular mass:
    51103 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15356.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ODR4 Gene


neXtProt entry for ODR4 Gene

Post-translational modifications for ODR4 Gene

No Post-translational modifications

Other Protein References for ODR4 Gene

No data available for DME Specific Peptides for ODR4 Gene

Domains & Families for ODR4 Gene

Gene Families for ODR4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ODR4 Gene


Suggested Antigen Peptide Sequences for ODR4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ODR-4 family.
  • Belongs to the ODR-4 family.
genes like me logo Genes that share domains with ODR4: view

Function for ODR4 Gene

Molecular function for ODR4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the trafficking of a subset of G-protein coupled receptors.

Phenotypes From GWAS Catalog for ODR4 Gene

genes like me logo Genes that share phenotypes with ODR4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODR4 Gene

Localization for ODR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODR4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODR4 gene
Compartment Confidence
plasma membrane 4
nucleus 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ODR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ODR4: view

Pathways & Interactions for ODR4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ODR4 Gene


No data available for Pathways by source and SIGNOR curated interactions for ODR4 Gene

Drugs & Compounds for ODR4 Gene

No Compound Related Data Available

Transcripts for ODR4 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODR4 Gene

No ASD Table

Relevant External Links for ODR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ODR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ODR4 Gene:


mRNA Expression by UniProt/SwissProt for ODR4 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ODR4 Gene

  • Liver(4.3)
  • Lung(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ODR4: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODR4 Gene

Orthologs for ODR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ODR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1orf27 34
  • 100 (a)
C1H1orf27 33
  • 99.85 (n)
(Bos Taurus)
Mammalia C16H1orf27 33
  • 90.82 (n)
C1orf27 34
  • 89 (a)
(Canis familiaris)
Mammalia C7H1orf27 33
  • 90.68 (n)
C1orf27 34
  • 88 (a)
(Mus musculus)
Mammalia BC003331 34 16 33
  • 87.84 (n)
(Rattus norvegicus)
Mammalia RGD1307830 33
  • 87.4 (n)
(Monodelphis domestica)
Mammalia C1orf27 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia C1orf27 34
  • 70 (a)
(Gallus gallus)
Aves C8H1ORF27 33 34
  • 69.88 (n)
(Anolis carolinensis)
Reptilia C1orf27 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf27 33
  • 59.55 (n)
Str.15466 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10013 33
(Danio rerio)
Actinopterygii zgc:63674 33
  • 53.71 (n)
C2H1orf27 34
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006119 33
  • 41.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10616 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
Species where no ortholog for ODR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ODR4 Gene

Gene Tree for ODR4 (if available)
Gene Tree for ODR4 (if available)

Paralogs for ODR4 Gene

No data available for Paralogs for ODR4 Gene

Variants for ODR4 Gene

Sequence variations from dbSNP and Humsavar for ODR4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000085484 -- 186,392,745(+) G/C intron_variant
rs1000113607 -- 186,400,913(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000116726 -- 186,392,972(+) T/C intron_variant
rs1000169648 -- 186,374,028(+) G/A upstream_transcript_variant
rs1000274946 -- 186,416,438(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ODR4 Gene

Variant ID Type Subtype PubMed ID
esv2762201 CNV gain 21179565
esv3575361 CNV gain 25503493
esv3890826 CNV gain 25118596
nsv1012164 CNV gain 25217958
nsv548399 CNV loss 21841781

Variation tolerance for ODR4 Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.53; 85.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ODR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODR4 Gene

Disorders for ODR4 Gene

Additional Disease Information for ODR4

No disorders were found for ODR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ODR4 Gene

Publications for ODR4 Gene

  1. Ubiquitously expressed GPCR membrane-trafficking orthologs. (PMID: 15718105) Lehman CW … Komives CF (Genomics 2005) 2 3 4 58
  2. An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism. (PMID: 24603482) Chen C … de Bono M (PLoS genetics 2014) 2 3 58
  3. Protein expression, genomic structure, and polymorphisms of oculomedin. (PMID: 12868032) Fujiwara N … Ohtsuki H (Ophthalmic genetics 2003) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. (PMID: 28162770) Wang T … Sabatini DM (Cell 2017) 3 58

Products for ODR4 Gene

Sources for ODR4 Gene

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