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ODF4 Gene

protein-coding GIFtS: 46

GC17P008183

outer dense fiber of sperm tails 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC138215 ^²
MGC138219 ^²
OPPO1 ^¹, ², ³, ⁵
hOPPO1 ^³

Descriptions
Outer dense fiber of sperm tails protein 4 ^³
Testis-specific protein oppo 1 ^², ³
outer dense fiber 4 ^²
outer dense fiber of sperm tails 4 ^²

External Ids
HGNC: 19056¹
Entrez Gene: 146852²
UniProtKB: Q2M2E3³
Ensembl: ENSG00000184650⁷

Search outside databases for aliases for ODF4 gene

Previous GC identifers: GC17P008978 GC17P008186 GC17P008443

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ODF4:

This gene encodes a protein that is localized in the outer dense fibers of the tails of mature

sperm. This protein is thought to have some important role in the sperm tail. [provided by RefSeq]

UniProtKB/Swiss-Prot: ODFP4_HUMAN, Q2M2E3

Function: Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm

tail structure, sperm movement and general organization of cellular cytoskeleton (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ODF4 gene

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p12

ODF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P008183: (about GC identifiers)

Start:	8,183,913 bp from pter
End:	8,190,088 bp from pter
Size:	6,176 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ODFP4_HUMAN, Q2M2E3 (See protein sequence)

Recommended Name: Outer dense fiber protein 4

Size: 257 amino acids; 29233 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q8J021

REFSEQ proteins: NP_694552.2

ENSEMBL proteins:

ENSP00000331086

Human Recombinant Proteins

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	Human Recombinant Proteins from Abnova (ODF4)

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4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001520	outer dense fiber	IEA	--
GO:0009434	microtubule-based flagellum	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for ODF4:

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	Search Novus for antibodies for ODF4

Assays for ODF4:

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	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q2M2E3

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ODF4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153007

Applied Biosystems Silencer® siRNAs for ODF4

Sigma-Aldrich siRNA for ODF4

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_153007
Myc/DDK tagged cDNA clone in CMV expression vector: NM_153007
untagged cDNA clone in CMV expression vector: NM_153007

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_153007

UniProtKB/Swiss-Prot: ODFP4_HUMAN, Q2M2E3

Function: Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm

tail structure, sperm movement and general organization of cellular cytoskeleton (By similarity)

1 MGI phenotypic allele for Odf4 (no phenotypes)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for ODF4 (ENSP00000331086³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZNF8	ENSP00000196548³	STRING (score=.706)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	IEA	--
GO:0007283	spermatogenesis	IEA	--
GO:0030154	cell differentiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ODF4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ODF4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153007

Sigma-Aldrich siRNA for ODF4

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_153007

REFSEQ mRNAs for ODF4 gene:

NM_153007.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_153007

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_153007
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_153007
                                 untagged cDNA clone in CMV expression vector: NM_153007

Additional cDNA sequence:

AB081120.1 AY237799.1 BC112010.1 BC112014.1

1 DOTS entry:

DT.100016303

8 AceView cDNA sequences:

AA583225 BX094858 AB081120 NM_153007 AI862103 AY237799 AI125365 AI968783

highest scoring ESTs for ODF4:

AI968783 AB081120 AI125365 AY237799 AA583225 AI862103 BX094858 NM_153007 BC112010 BC112014

Unigene Cluster for ODF4:

Outer dense fiber of sperm tails 4

Hs.186045 [show with all ESTs]

Unigene Representative Sequence: AY237799

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ODF4

ExUns:	1a	·	1b	^	2	^	3a	·	3b
SP1:			-
SP2:

About this scheme

ECgene alternative splicing isoforms for ODF4

1 Ensembl transcript including schematic representation:

ENST00000328248

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ODF4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ODF4

¹ / ² / ³

3 probe-sets matching ODF4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
67498_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AI968783	1.00	1.00	1.00	1
1552409_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1552408_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTAATCTTT

SOURCE GeneReport for Unigene cluster: Hs.186045
UniProtKB/Swiss-Prot: ODFP4_HUMAN, Q2M2E3
Tissue specificity: Expressed in testis and sperm; especially localized to sperm tail (at protein
level)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ODF4 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ODF4¹	--	outer dense fiber of sperm tails 4	68.9(n) 55.67(a)	479495 XM_536634.2 XP_536634.1
chimpanzee (Pan troglodytes)	ODF4¹	--	outer dense fiber of sperm tails 4	95.33(n) 93.39(a)	747075 XM_001155818.1 XP_001155818.1
rat (Rattus norvegicus)	Odf4¹	--	outer dense fiber of sperm tails 4	63.05(n) 51.72(a)	303236 NM_001007670.1 NP_001007671.1
mouse (Mus musculus)	Odf4^{1, 5}	11⁵	outer dense fiber of sperm tails 4^{1, 5}	64.85(n)¹ 55.45(a)¹	252868¹ NM_145746.1¹ NP_665689.1¹ AB074438⁵ AL603662⁵ (see all 6)

About this table Species with no ortholog for ODF4

ENSEMBL Gene Tree for ODF4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/93 NCBI SNPs in ODF4 are shown (see all 93 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 23)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs12952489^1,2	A,C,F,H	8182616(+)	`taaccG/Agacat`	1	--	ng5¹		8	EU EA WA	838
	rs12936935^1,2	A,C,F,H	8184510(+)	`CTTTTA/GCAAAT`	1	Y/C	mis¹ ese³		12	EU EA WA NA	1056
--	rs4792329^1,2	A,C,F	8182502(+)	`ctgacT/Agcaat`	1	--	ng5¹		3	NA	128
	rs12601097^1,2	A,C,F	8184386(+)	`TGGTCG/ATGGCC`	1	M/V	mis¹ ese³		6	EA EU WA	600
--	rs6503102^1,2	A,C,F	8181915(+)	`agtcaA/Gaagaa`	1	--	ng5¹ trp³		4	EA NA	212
	rs8069620^1,2	C,F,H	8182376(+)	`aataaA/Gccagt`	1	--	ng5¹		4	EU EA WA	400
	rs12943505^1,2	C,F	8184194(+)	`CAGGAC/TGGGGC`	1	W/R	mis¹		4	EU EA WA	418
	rs8069158^1,2	F,H	8182398(+)	`attttC/Tgagtt`	1	--	ng5¹		4	EU EA WA	386
	rs2302869^1,2	C,F,H	8189841(+)	`GACACC/TCCCAT`	1	T/T	syn¹ ese³		5	EA EU WA	1902
	rs9899369^1,2	A,C,F,H	8187637(+)	`CCCACC/TAGGAG`	1	--	int¹		3	EA WA	266

About this table

HapMap Linkage Disequilibrium images for ODF4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610097

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for ODF4 gene:

Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein. (PubMed id 12728016)^{1, 3, 4} Kitamura K....Nishimune Y. (2003)
Isolation and expression analysis of the testis-specific gene, human OPPO1. (PubMed id 15270212)³ Miyamoto T....Ishikawa M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 146852	HGNC: 19056	AceView: ODF4	Ensembl:ENSG00000184650	euGenes: HUgn146852
ECgene: ODF4	H-InvDB: ODF4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ODF4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ODF4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ODF4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ODF4		Browse antibodies at Sigma-Aldrich
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	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ODF4)
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Search Novus for antibodies for ODF4

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ODF4 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for ODF4

Summaries
for ODF4

Genomic Location
for ODF4

Proteins
for ODF4

Protein Domains/
Families
for ODF4

Gene Function
for ODF4

Pathways & Interactions
for ODF4

Drugs & Compounds
for ODF4

Transcripts
for ODF4

Expression
for ODF4

Orthologs
for ODF4

Paralogs
for ODF4

SNPs/Variants
for ODF4

Disorders & Mutations
for ODF4

Medical News
for ODF4

Publications
for ODF4

Search for ODF4

Genome Databases showing ODF4

Other Databases showing ODF4

Specialized Databases showing ODF4

Licensable Technologies
for ODF4

Services
for ODF4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ODF4 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor ODF4

Summariesfor ODF4

Genomic Locationfor ODF4

Proteinsfor ODF4

Protein Domains/Familiesfor ODF4

Gene Functionfor ODF4

Pathways & Interactionsfor ODF4

Drugs & Compoundsfor ODF4

Transcriptsfor ODF4

Expression for ODF4

Orthologsfor ODF4

Paralogsfor ODF4

SNPs/Variantsfor ODF4

Disorders & Mutationsfor ODF4

Medical Newsfor ODF4

Publicationsfor ODF4

Search for ODF4

Genome Databases showing ODF4

Other Databases showing ODF4

Specialized Databases showing ODF4

Licensable Technologiesfor ODF4

Servicesfor ODF4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ODF4

Summaries
for ODF4

Genomic Location
for ODF4

Proteins
for ODF4

Protein Domains/
Families
for ODF4

Gene Function
for ODF4

Pathways & Interactions
for ODF4

Drugs & Compounds
for ODF4

Transcripts
for ODF4

Expression
for ODF4

Orthologs
for ODF4

Paralogs
for ODF4

SNPs/Variants
for ODF4

Disorders & Mutations
for ODF4

Medical News
for ODF4

Publications
for ODF4

Licensable Technologies
for ODF4

Services
for ODF4