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Aliases for ODF4 Gene

Aliases for ODF4 Gene

  • Outer Dense Fiber Of Sperm Tails 4 2 3
  • OPPO1 3 4 6
  • Outer Dense Fiber Of Sperm Tails Protein 4 3 4
  • Testis-Specific Protein Oppo 1 3 4
  • Cancer/Testis Antigen 136 2 3
  • HOPPO1 3 4
  • Outer Dense Fiber Protein 4 3
  • Cancer/Testis Antigen 134 3
  • Outer Dense Fiber 4 3
  • CT134 3
  • CT136 3

External Ids for ODF4 Gene

Previous GeneCards Identifiers for ODF4 Gene

  • GC17P008978
  • GC17P008186
  • GC17P008443
  • GC17P008183
  • GC17P008243

Summaries for ODF4 Gene

Entrez Gene Summary for ODF4 Gene

  • This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. [provided by RefSeq, Jul 2008]

GeneCards Summary for ODF4 Gene

ODF4 (Outer Dense Fiber Of Sperm Tails 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ODF4 Gene

  • Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF4 Gene

Genomics for ODF4 Gene

Regulatory Elements for ODF4 Gene

Genomic Location for ODF4 Gene

Start:
8,339,840 bp from pter
End:
8,346,046 bp from pter
Size:
6,207 bases
Orientation:
Plus strand

Genomic View for ODF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ODF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF4 Gene

Proteins for ODF4 Gene

  • Protein details for ODF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2E3-ODFP4_HUMAN
    Recommended name:
    Outer dense fiber protein 4
    Protein Accession:
    Q2M2E3
    Secondary Accessions:
    • Q8J021

    Protein attributes for ODF4 Gene

    Size:
    257 amino acids
    Molecular mass:
    29233 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ODF4 Gene

Proteomics data for ODF4 Gene at MOPED

Post-translational modifications for ODF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ODF4 Gene

Domains for ODF4 Gene

Protein Domains for ODF4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ODF4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ODF4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ODF4 Gene

Function for ODF4 Gene

Molecular function for ODF4 Gene

UniProtKB/Swiss-Prot Function: Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ODF4 Gene

Localization for ODF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODF4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ODF4 Gene COMPARTMENTS Subcellular localization image for ODF4 gene
Compartment Confidence
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for ODF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001520 outer dense fiber IEA --
GO:0016021 integral component of membrane IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with ODF4: view

Pathways for ODF4 Gene

SuperPathways for ODF4 Gene

No Data Available

Interacting Proteins for ODF4 Gene

Gene Ontology (GO) - Biological Process for ODF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ODF4: view

No data available for Pathways by source for ODF4 Gene

Transcripts for ODF4 Gene

mRNA/cDNA for ODF4 Gene

(4) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ODF4 Gene

Outer dense fiber of sperm tails 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ODF4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ODF4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for ODF4 Gene

GeneLoc Exon Structure for
ODF4
ECgene alternative splicing isoforms for
ODF4

Expression for ODF4 Gene

mRNA expression in normal human tissues for ODF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ODF4 Gene

This gene is overexpressed in Testis (49.6).

SOURCE GeneReport for Unigene cluster for ODF4 Gene Hs.186045

mRNA Expression by UniProt/SwissProt for ODF4 Gene

Q2M2E3-ODFP4_HUMAN
Tissue specificity: Expressed in testis and sperm; especially localized to sperm tail (at protein level).
genes like me logo Genes that share expressions with ODF4: view

In Situ Assay Products

No data available for Protein expression for ODF4 Gene

Orthologs for ODF4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ODF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODF4 35
  • 98.57 (n)
  • 97.67 (a)
ODF4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ODF4 36
  • 31 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ODF4 35
  • 66.14 (n)
  • 51.79 (a)
ODF4 36
  • 40 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Odf4 35
  • 66.5 (n)
  • 54.59 (a)
Odf4 16
Odf4 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ODF4 36
  • 18 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Odf4 35
  • 69.82 (n)
  • 55.79 (a)
Species with no ortholog for ODF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ODF4 Gene

ENSEMBL:
Gene Tree for ODF4 (if available)
TreeFam:
Gene Tree for ODF4 (if available)

Paralogs for ODF4 Gene

No data available for Paralogs for ODF4 Gene

Variants for ODF4 Gene

Sequence variations from dbSNP and Humsavar for ODF4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs918274 -- 8,344,335(+) tctgt(A/C)cattt intron-variant
rs2008274 -- 8,344,088(+) ccgac(A/C)CCAAT intron-variant
rs2302869 -- 8,345,798(+) GACAC(C/T)CCCAT reference, synonymous-codon
rs4791531 -- 8,340,978(+) AAGGT(C/T)GGGAG intron-variant
rs4792329 -- 8,338,459(+) ctgac(A/T)gcaat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ODF4 Gene

Variant ID Type Subtype PubMed ID
nsv907661 CNV Gain 21882294
nsv1967 CNV Loss 18451855
nsv457664 CNV Gain 19166990
esv989739 CNV Deletion 20482838
esv2555685 CNV Deletion 19546169
nsv512476 CNV Loss 21212237
esv2715613 CNV Deletion 23290073
esv1978259 CNV Deletion 18987734

Relevant External Links for ODF4 Gene

HapMap Linkage Disequilibrium report
ODF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF4 Gene

Disorders for ODF4 Gene

No disorders were found for ODF4 Gene.

No data available for UniProtKB/Swiss-Prot for ODF4 Gene

Publications for ODF4 Gene

  1. Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein. (PMID: 12728016) Kitamura K. … Nishimune Y. (Mol. Hum. Reprod. 2003) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Isolation and expression analysis of the testis-specific gene, human OPPO1. (PMID: 15270212) Miyamoto T. … Ishikawa M. (J. Assist. Reprod. Genet. 2004) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Expression of testis-specific genes, TEX101 and ODF4, in chronic myeloid leukemia and evaluation of TEX101 immunogenicity. (PMID: 22588436) Ghafouri-Fard S. … Yazarloo F. (Ann Saudi Med 2012) 3

Products for ODF4 Gene

Sources for ODF4 Gene

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