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Aliases for ODF4 Gene

Aliases for ODF4 Gene

  • Outer Dense Fiber Of Sperm Tails 4 2 3 5
  • Outer Dense Fiber Of Sperm Tails Protein 4 3 4
  • Testis-Specific Protein Oppo 1 3 4
  • Cancer/Testis Antigen 136 2 3
  • HOPPO1 3 4
  • OPPO1 3 4
  • Outer Dense Fiber Protein 4 3
  • Cancer/Testis Antigen 134 3
  • Outer Dense Fiber 4 3
  • CT134 3
  • CT136 3

External Ids for ODF4 Gene

Previous GeneCards Identifiers for ODF4 Gene

  • GC17P008978
  • GC17P008186
  • GC17P008443
  • GC17P008183
  • GC17P008243

Summaries for ODF4 Gene

Entrez Gene Summary for ODF4 Gene

  • This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for ODF4 Gene

ODF4 (Outer Dense Fiber Of Sperm Tails 4) is a Protein Coding gene. Diseases associated with ODF4 include Breast Benign Neoplasm and Thoracic Benign Neoplasm.

UniProtKB/Swiss-Prot for ODF4 Gene

  • Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.

Additional gene information for ODF4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF4 Gene

Genomics for ODF4 Gene

GeneHancer (GH) Regulatory Elements for ODF4 Gene

Promoters and enhancers for ODF4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I008338 Enhancer 1.1 FANTOM5 Ensembl ENCODE 564.5 -1.3 -1270 1.1 HDAC1 MEIS2 LEF1 PKNOX1 ATF1 MAX ZIC2 CTBP1 ZNF766 NFE2 ODF4 ENSG00000266279 ENSG00000226871 NDEL1 KDM6B PER1
GH17I008339 Promoter 0.5 EPDnew 550.8 0.0 -14 0.1 ODF4 ENSG00000266279
GH17I008341 Enhancer 0.4 ENCODE 564.4 +1.8 1841 0.2 ZNF362 IKZF1 ODF4 ENSG00000226871 LOC100128288
GH17I008364 Enhancer 0.9 FANTOM5 Ensembl ENCODE 57.4 +26.1 26139 2.4 STAT1 POLR2A JUN ZNF600 ATF2 ENSG00000265749 ODF4 CCDC42 SPDYE4 ENSG00000212206 ENSG00000226871 RNF222 NDEL1 MFSD6L CNTROB
GH17I008375 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22 +36.7 36664 2.3 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 POLR2B E2F8 KRBA2 PIR59981 ODF4 ENSG00000265749 RNF222 ENSG00000212206 ENSG00000263809 RPL26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ODF4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ODF4 gene promoter:

Genomic Locations for ODF4 Gene

Genomic Locations for ODF4 Gene
chr17:8,339,837-8,346,048
(GRCh38/hg38)
Size:
6,212 bases
Orientation:
Plus strand
chr17:8,243,182-8,249,364
(GRCh37/hg19)

Genomic View for ODF4 Gene

Genes around ODF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF4 Gene

Proteins for ODF4 Gene

  • Protein details for ODF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2E3-ODFP4_HUMAN
    Recommended name:
    Outer dense fiber protein 4
    Protein Accession:
    Q2M2E3
    Secondary Accessions:
    • Q8J021

    Protein attributes for ODF4 Gene

    Size:
    257 amino acids
    Molecular mass:
    29233 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ODF4 Gene

Post-translational modifications for ODF4 Gene

No Post-translational modifications

Other Protein References for ODF4 Gene

No data available for DME Specific Peptides for ODF4 Gene

Domains & Families for ODF4 Gene

Gene Families for ODF4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ODF4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ODF4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ODF4: view

No data available for UniProtKB/Swiss-Prot for ODF4 Gene

Function for ODF4 Gene

Molecular function for ODF4 Gene

UniProtKB/Swiss-Prot Function:
Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.

Phenotypes From GWAS Catalog for ODF4 Gene

Gene Ontology (GO) - Molecular Function for ODF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23355646
genes like me logo Genes that share ontologies with ODF4: view

Phenotypes for ODF4 Gene

GenomeRNAi human phenotypes for ODF4:
genes like me logo Genes that share phenotypes with ODF4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODF4 Gene

Localization for ODF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODF4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODF4 gene
Compartment Confidence
plasma membrane 3
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ODF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ODF4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ODF4 Gene

Pathways & Interactions for ODF4 Gene

No Data Available

Interacting Proteins for ODF4 Gene

Selected Interacting proteins: Q2M2E3-ODFP4_HUMAN for ODF4 Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for ODF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ODF4: view

No data available for Pathways by source and SIGNOR curated interactions for ODF4 Gene

Drugs & Compounds for ODF4 Gene

No Compound Related Data Available

Transcripts for ODF4 Gene

mRNA/cDNA for ODF4 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ODF4 Gene

Outer dense fiber of sperm tails 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for ODF4 Gene

GeneLoc Exon Structure for
ODF4
ECgene alternative splicing isoforms for
ODF4

Expression for ODF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ODF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ODF4 Gene

This gene is overexpressed in Testis (x49.6).

NURSA nuclear receptor signaling pathways regulating expression of ODF4 Gene:

ODF4

SOURCE GeneReport for Unigene cluster for ODF4 Gene:

Hs.186045

mRNA Expression by UniProt/SwissProt for ODF4 Gene:

Q2M2E3-ODFP4_HUMAN
Tissue specificity: Expressed in testis and sperm; especially localized to sperm tail (at protein level).
genes like me logo Genes that share expression patterns with ODF4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODF4 Gene

Orthologs for ODF4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ODF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODF4 33 34
  • 98.57 (n)
rat
(Rattus norvegicus)
Mammalia Odf4 33
  • 69.82 (n)
mouse
(Mus musculus)
Mammalia Odf4 33 16 34
  • 66.5 (n)
dog
(Canis familiaris)
Mammalia ODF4 33 34
  • 66.14 (n)
cow
(Bos Taurus)
Mammalia ODF4 34
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ODF4 34
  • 18 (a)
OneToOne
Species where no ortholog for ODF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ODF4 Gene

ENSEMBL:
Gene Tree for ODF4 (if available)
TreeFam:
Gene Tree for ODF4 (if available)

Paralogs for ODF4 Gene

No data available for Paralogs for ODF4 Gene

Variants for ODF4 Gene

Sequence variations from dbSNP and Humsavar for ODF4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000043834 -- 8,339,620(+) G/C upstream_transcript_variant
rs1000946475 -- 8,341,304(+) T/C intron_variant
rs1000955481 -- 8,343,641(+) A/G intron_variant
rs1001519921 -- 8,339,787(+) T/A upstream_transcript_variant
rs1001550566 -- 8,342,598(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ODF4 Gene

Variant ID Type Subtype PubMed ID
dgv70n73 CNV deletion 24416366
esv1978259 CNV deletion 18987734
esv2555685 CNV deletion 19546169
esv2715613 CNV deletion 23290073
esv3554097 CNV deletion 23714750
esv3639881 CNV gain 21293372
esv3639883 CNV loss 21293372
esv989739 CNV deletion 20482838
nsv1141774 CNV deletion 24896259
nsv1151481 CNV deletion 26484159
nsv1967 CNV deletion 18451855
nsv457664 CNV gain 19166990
nsv512476 CNV loss 21212237
nsv574337 CNV gain 21841781

Variation tolerance for ODF4 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ODF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ODF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF4 Gene

Disorders for ODF4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ODF4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
breast benign neoplasm
thoracic benign neoplasm
  • benign neoplasm of thorax
- elite association - COSMIC cancer census association via MalaCards
Search ODF4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ODF4

genes like me logo Genes that share disorders with ODF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ODF4 Gene

Publications for ODF4 Gene

  1. Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein. (PMID: 12728016) Kitamura K … Nishimune Y (Molecular human reproduction 2003) 3 4 22 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Identification of sperm head proteins involved in zona pellucida binding. (PMID: 23355646) Petit FM … Auer J (Human reproduction (Oxford, England) 2013) 3 58
  4. Expression of testis-specific genes, TEX101 and ODF4, in chronic myeloid leukemia and evaluation of TEX101 immunogenicity. (PMID: 22588436) Ghafouri-Fard S … Yazarloo F (Annals of Saudi medicine 2012) 3 58
  5. Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient. (PMID: 23096689) Ghafouri-Fard S … Modarressi MH (Genetics and molecular research : GMR 2012) 3 58

Products for ODF4 Gene

Sources for ODF4 Gene

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