Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ODF4 Gene

Aliases for ODF4 Gene

  • Outer Dense Fiber Of Sperm Tails 4 2 3 5
  • Outer Dense Fiber Of Sperm Tails Protein 4 3 4
  • Testis-Specific Protein Oppo 1 3 4
  • Cancer/Testis Antigen 136 2 3
  • HOPPO1 3 4
  • OPPO1 3 4
  • Outer Dense Fiber Protein 4 3
  • Cancer/Testis Antigen 134 3
  • Outer Dense Fiber 4 3
  • CT134 3
  • CT136 3

External Ids for ODF4 Gene

Previous GeneCards Identifiers for ODF4 Gene

  • GC17P008978
  • GC17P008186
  • GC17P008443
  • GC17P008183
  • GC17P008243

Summaries for ODF4 Gene

Entrez Gene Summary for ODF4 Gene

  • This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for ODF4 Gene

ODF4 (Outer Dense Fiber Of Sperm Tails 4) is a Protein Coding gene. Diseases associated with ODF4 include Thoracic Benign Neoplasm and Breast Benign Neoplasm.

UniProtKB/Swiss-Prot for ODF4 Gene

  • Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF4 Gene

Genomics for ODF4 Gene

Regulatory Elements for ODF4 Gene

Enhancers for ODF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G008364 1.1 FANTOM5 Ensembl ENCODE 57.4 +26.1 26140 2.4 STAT1 ZNF366 SMARCA4 POLR2A JUN ZNF600 ATF2 ODF4 CCDC42 SPDYE4 ENSG00000265749 ENSG00000212206 ENSG00000226871 RNF222 NDEL1 MFSD6L CNTROB
GH17G008375 1.1 ENCODE 22 +36.7 36664 2.3 HDGF PKNOX1 AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143 ODF4 ENSG00000265749 KRBA2 RNF222 ENSG00000212206 PIR59981
GH17G008128 0.7 FANTOM5 31.3 -211.2 -211248 0.2 FOXA2 RFX1 ZBTB2 FOXA3 FOXA1 RARA GATA3 MIER3 ZNF366 CEBPA ODF4 SNORD118 TMEM107 BORCS6 CHD3 ALOX15B CNTROB LOC105376799 TRS-CGA1-1 GC17M008436
GH17G008744 1.3 FANTOM5 ENCODE 15.5 +405.8 405759 1.9 HDGF ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF143 FOS SP3 MXD4 CCDC42 SPDYE4 ODF4 MFSD6L
GH17G008338 1.3 FANTOM5 Ensembl ENCODE 14.5 -1.3 -1271 1.1 HDAC1 LEF1 PKNOX1 ATF1 MAX ZIC2 ZNF766 ZNF239 NFE2 CREM ODF4 NDEL1 KDM6B PER1 ENSG00000266279
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ODF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ODF4 Gene

Chromosome:
17
Start:
8,339,837 bp from pter
End:
8,346,048 bp from pter
Size:
6,212 bases
Orientation:
Plus strand

Genomic View for ODF4 Gene

Genes around ODF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF4 Gene

Proteins for ODF4 Gene

  • Protein details for ODF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2E3-ODFP4_HUMAN
    Recommended name:
    Outer dense fiber protein 4
    Protein Accession:
    Q2M2E3
    Secondary Accessions:
    • Q8J021

    Protein attributes for ODF4 Gene

    Size:
    257 amino acids
    Molecular mass:
    29233 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ODF4 Gene

Post-translational modifications for ODF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODF4 Gene

No data available for DME Specific Peptides for ODF4 Gene

Domains & Families for ODF4 Gene

Protein Domains for ODF4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ODF4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ODF4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ODF4 Gene

Function for ODF4 Gene

Molecular function for ODF4 Gene

UniProtKB/Swiss-Prot Function:
Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.

Phenotypes for ODF4 Gene

GenomeRNAi human phenotypes for ODF4:
genes like me logo Genes that share phenotypes with ODF4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODF4 Gene

Localization for ODF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODF4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODF4 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ODF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001520 outer dense fiber IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with ODF4: view

Pathways & Interactions for ODF4 Gene

No Data Available

Interacting Proteins for ODF4 Gene

Selected Interacting proteins: Q2M2E3-ODFP4_HUMAN for ODF4 Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for ODF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ODF4: view

No data available for Pathways by source and SIGNOR curated interactions for ODF4 Gene

Transcripts for ODF4 Gene

mRNA/cDNA for ODF4 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ODF4 Gene

Outer dense fiber of sperm tails 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for ODF4 Gene

GeneLoc Exon Structure for
ODF4
ECgene alternative splicing isoforms for
ODF4

Expression for ODF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ODF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ODF4 Gene

This gene is overexpressed in Testis (x49.6).

NURSA nuclear receptor signaling pathways regulating expression of ODF4 Gene:

ODF4

SOURCE GeneReport for Unigene cluster for ODF4 Gene:

Hs.186045

mRNA Expression by UniProt/SwissProt for ODF4 Gene:

Q2M2E3-ODFP4_HUMAN
Tissue specificity: Expressed in testis and sperm; especially localized to sperm tail (at protein level).
genes like me logo Genes that share expression patterns with ODF4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODF4 Gene

Orthologs for ODF4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ODF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODF4 34 35
  • 98.57 (n)
rat
(Rattus norvegicus)
Mammalia Odf4 34
  • 69.82 (n)
mouse
(Mus musculus)
Mammalia Odf4 34 16 35
  • 66.5 (n)
dog
(Canis familiaris)
Mammalia ODF4 34 35
  • 66.14 (n)
cow
(Bos Taurus)
Mammalia ODF4 35
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ODF4 35
  • 18 (a)
OneToOne
Species where no ortholog for ODF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ODF4 Gene

ENSEMBL:
Gene Tree for ODF4 (if available)
TreeFam:
Gene Tree for ODF4 (if available)

Paralogs for ODF4 Gene

No data available for Paralogs for ODF4 Gene

Variants for ODF4 Gene

Sequence variations from dbSNP and Humsavar for ODF4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000043834 -- 8,339,620(+) ATGCT(C/G)GCACA upstream-variant-2KB
rs1000946475 -- 8,341,304(+) TCTTG(C/T)GTACC intron-variant
rs1000955481 -- 8,343,641(+) ATACT(A/G)GGTGT intron-variant
rs1001519921 -- 8,339,787(+) AAAAA(A/T)TGCTG upstream-variant-2KB
rs1001550566 -- 8,342,598(+) GTGTA(C/T)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ODF4 Gene

Variant ID Type Subtype PubMed ID
dgv70n73 CNV deletion 24416366
esv1978259 CNV deletion 18987734
esv2555685 CNV deletion 19546169
esv2715613 CNV deletion 23290073
esv3554097 CNV deletion 23714750
esv3639881 CNV gain 21293372
esv3639883 CNV loss 21293372
esv989739 CNV deletion 20482838
nsv1141774 CNV deletion 24896259
nsv1151481 CNV deletion 26484159
nsv1967 CNV deletion 18451855
nsv457664 CNV gain 19166990
nsv512476 CNV loss 21212237
nsv574337 CNV gain 21841781

Variation tolerance for ODF4 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ODF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ODF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF4 Gene

Disorders for ODF4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ODF4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
thoracic benign neoplasm
  • benign neoplasm of thorax
breast benign neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search ODF4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ODF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ODF4
genes like me logo Genes that share disorders with ODF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ODF4 Gene

Publications for ODF4 Gene

  1. Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein. (PMID: 12728016) Kitamura K. … Nishimune Y. (Mol. Hum. Reprod. 2003) 3 4 22 64
  2. Expression of testis-specific genes, TEX101 and ODF4, in chronic myeloid leukemia and evaluation of TEX101 immunogenicity. (PMID: 22588436) Ghafouri-Fard S. … Yazarloo F. (Ann Saudi Med 2012) 3 64
  3. Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient. (PMID: 23096689) Ghafouri-Fard S. … Modarressi M.H. (Genet. Mol. Res. 2012) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for ODF4 Gene

Sources for ODF4 Gene

Content
Loading form....