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ODF3L1 Gene

protein-coding   GIFtS: 40

GC15P073805
outer dense fiber of sperm tails 3-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC48986 1, 2
Descriptions
outer dense fiber of sperm tails 3-like 1 2
External Ids
HGNC: 287351
Entrez Gene: 1617532
UniProtKB: Q8IXM73
Ensembl: ENSG000001829507
Search outside databases for aliases for ODF3L1 gene

Previous GC identifer: GC15P073804

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ODF3L1 gene  

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q23

ODF3L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P073805:     (about GC identifiers)

Start:
73,803,374 bp from pter
End:
73,807,082 bp from pter
Size:
3,709 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000015.8  NT_010194.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OD3L1_HUMAN, Q8IXM7 (See protein sequence)
Recommended Name: Outer dense fiber protein 3-like protein 1  
Size: 274 amino acids; 31065 Da

REFSEQ proteins: NP_787077.1  

ENSEMBL proteins: 
ENSP00000329584 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ODF3L1)
Browse Abnova for Human Recombinant Proteins
              OriGene Purified Recombinant Human Protein: ODF3L1 


Antibodies for ODF3L1: 
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Browse Antibodies at Sigma-Aldrich
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Antibodies from Abcam (ODF3L1), each with their AbpromiseSM
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Search Novus for antibodies for ODF3L1

Assays for ODF3L1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR010736 DUF1309


   GeneDecks  ODF3L1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8IXM7

ProtoNet protein and cluster: Q8IXM7

UniProtKB/Swiss-Prot: OD3L1_HUMAN, Q8IXM7
Similarity: Belongs to the ODF3 family
Similarity: Contains 2 DUF1309 repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ODF3L1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175881

              Applied Biosystems Silencer® siRNAs for ODF3L1

              Sigma-Aldrich siRNA for ODF3L1  
                     Sigma-Aldrich shRNA for ODF3L1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for ODF3L1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_175881
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_175881
                                 untagged cDNA clone in CMV expression vector: NM_175881 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_175881

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ODF3L1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ODF3L1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175881

              Sigma-Aldrich siRNA for ODF3L1  
                     Sigma-Aldrich shRNA for ODF3L1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_175881  

REFSEQ mRNAs for ODF3L1 gene: 

NM_175881.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_175881  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_175881
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_175881
                                 untagged cDNA clone in CMV expression vector: NM_175881 

Additional cDNA sequence: BC039862.1 

1 DOTS entry:

DT.99935653 

10 AceView cDNA sequences:

NM_175881 BC039862 BX114387 AI206644 AI671497 AI554042 AW236843 AI393597 
AI201316 AA406451 

highest scoring ESTs for ODF3L1:

AI554042 BC039862 AA410406 AI201316 AI206644 AI393597 AI671497 AW236843 BF853451 BX114387 

Unigene Cluster for ODF3L1:

Outer dense fiber of sperm tails 3-like 1
Hs.144348  [show with all ESTs]
Unigene Representative Sequence: BM559646


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000332145  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ODF3L1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ODF3L1

1 / 2 / 3

3 probe-sets matching ODF3L1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

75559_at2, 3 U95-E 1 1.00 1.00 1.00 1.00 AI554042 0.80 1.00 0.91 1

236245_at2, 3 U133-B 1 1.00 1.00 -- -- AI554042 0.80 1.00 0.91 1

236245_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGCATCAAGC

SOURCE GeneReport for Unigene cluster: Hs.144348
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for ODF3L1 gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ODF3L11   -- outer dense fiber of sperm tails 3-like 1 84.18(n)
78.83(a)
487659  XM_544784.2  XP_544784.2 
chimpanzee
(Pan troglodytes)
ODF3L11   -- outer dense fiber of sperm tails 3-like 1 99.39(n)
99.64(a)
467724  XM_523118.2  XP_523118.1 
rat
(Rattus norvegicus)
Odf3l11   -- outer dense fiber of sperm tails 3-like 1 79.2(n)
70.44(a)
315695  XM_236270.4  XP_236270.3 
mouse
(Mus musculus)
Odf3l11, 5 95
outer dense fiber of sperm tails 3-like 11, 5 81.27(n)1
71.9(a)1
3820751  NM_198673.11  NP_941075.11 
 AA4444325  AK1422195  (see all 6)
About this table        Species with no ortholog for ODF3L1

ENSEMBL Gene Tree for ODF3L1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for ODF3L1 gene
ODF3B2  ODF32  ODF3L22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/21 NCBI SNPs in ODF3L1 are shown (see all 21 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 22)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 15 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs48864561,2
A,C,F,H73802922(+) ACCACG/ACCCTG 1 -- ng518Minor allele frequency- A:0.42EU EA WA 838
rs101631121,2
A,C,F,H73802452(+) ATGTAG/ATAGGA 1 -- ng5112Minor allele frequency- A:0.30EU EA WA 1258
rs116373531,2
C,F,H73801484(+) AGGAGG/TTCTGG 1 -- ng518Minor allele frequency- T:0.19EU EA WA 836
rs133291041,2
A,C73803112(+) CACCCA/GTGACC 1 -- ng51 tfbs30--------
rs45037581,2
A,C,F,H73804227(+) ATCCAC/TGTCGG 1 -- int18Minor allele frequency- T:0.19EU EA WA 838
--
rs26752141,2
A73806072(+) AGTGGC/TGTGAT 1 -- int10--------
--
rs349624641,2
--73806792(+) GCCTAC/GCCTCT 1 Y/X non10--------
--
rs343255491,2
--73806864(+) CCCCAC/GATCCC 1 H/Q mis10--------
--
rs360595011,2
--73806759(+) CGCAGC/GCCTAC 1 S/R mis10--------
--
rs113417611,2
--73802179(+) CCCAG-/AAATCA 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for ODF3L1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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3 PubMed articles for ODF3L1 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 161753 HGNC: 28735 AceView: MGC48986 Ensembl:ENSG00000182950 euGenes: HUgn161753
ECgene: ODF3L1 H-InvDB: ODF3L1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ODF3L1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for ODF3L1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for ODF3L1 Browse small molecules at Sigma-Aldrich
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 shRNA in GFP-retroviral vector
 Search Tocris compounds for ODF3L1




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for ODF3L1

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