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Aliases for ODF3B Gene

Aliases for ODF3B Gene

  • Outer Dense Fiber Of Sperm Tails 3B 2 3 5
  • Outer Dense Fiber Protein 3-Like Protein 3 3 4
  • ODF3L3 3 4
  • Orf2 5 To PD-ECGF/TP 3

External Ids for ODF3B Gene

Previous GeneCards Identifiers for ODF3B Gene

  • GC22M049317
  • GC22M050968
  • GC22M033859

Summaries for ODF3B Gene

GeneCards Summary for ODF3B Gene

ODF3B (Outer Dense Fiber Of Sperm Tails 3B) is a Protein Coding gene. An important paralog of this gene is ODF3L1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF3B Gene

Genomics for ODF3B Gene

Regulatory Elements for ODF3B Gene

Promoters for ODF3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ODF3B on UCSC Golden Path with GeneCards custom track

Genomic Location for ODF3B Gene

Chromosome:
22
Start:
50,529,710 bp from pter
End:
50,532,580 bp from pter
Size:
2,871 bases
Orientation:
Minus strand

Genomic View for ODF3B Gene

Genes around ODF3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODF3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODF3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF3B Gene

Proteins for ODF3B Gene

  • Protein details for ODF3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYP8-ODF3B_HUMAN
    Recommended name:
    Outer dense fiber protein 3B
    Protein Accession:
    A8MYP8
    Secondary Accessions:
    • A0PK18

    Protein attributes for ODF3B Gene

    Size:
    253 amino acids
    Molecular mass:
    27280 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ODF3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ODF3B Gene

Proteomics data for ODF3B Gene at MOPED

Post-translational modifications for ODF3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODF3B Gene

No data available for DME Specific Peptides for ODF3B Gene

Domains & Families for ODF3B Gene

Protein Domains for ODF3B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ODF3B Gene

Graphical View of Domain Structure for InterPro Entry

A8MYP8

UniProtKB/Swiss-Prot:

ODF3B_HUMAN :
  • Belongs to the ODF3 family.
  • Contains 1 STPGR (Sperm-tail PG-rich) repeat.
Family:
  • Belongs to the ODF3 family.
Similarity:
  • Contains 1 STPGR (Sperm-tail PG-rich) repeat.
genes like me logo Genes that share domains with ODF3B: view

No data available for Gene Families for ODF3B Gene

Function for ODF3B Gene

Phenotypes for ODF3B Gene

GenomeRNAi human phenotypes for ODF3B:
genes like me logo Genes that share phenotypes with ODF3B: view

Animal Model Products

CRISPR Products

miRNA for ODF3B Gene

miRTarBase miRNAs that target ODF3B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODF3B Gene

Localization for ODF3B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ODF3B Gene COMPARTMENTS Subcellular localization image for ODF3B gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ODF3B Gene

Pathways & Interactions for ODF3B Gene

SuperPathways for ODF3B Gene

No Data Available

Interacting Proteins for ODF3B Gene

Gene Ontology (GO) - Biological Process for ODF3B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ODF3B Gene

Drugs & Compounds for ODF3B Gene

No Compound Related Data Available

Transcripts for ODF3B Gene

Unigene Clusters for ODF3B Gene

Outer dense fiber of sperm tails 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ODF3B Gene

No ASD Table

Relevant External Links for ODF3B Gene

GeneLoc Exon Structure for
ODF3B
ECgene alternative splicing isoforms for
ODF3B

Expression for ODF3B Gene

mRNA expression in normal human tissues for ODF3B Gene

mRNA differential expression in normal tissues according to GTEx for ODF3B Gene

This gene is overexpressed in Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for ODF3B Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ODF3B Gene



SOURCE GeneReport for Unigene cluster for ODF3B Gene Hs.531314

genes like me logo Genes that share expression patterns with ODF3B: view

Protein tissue co-expression partners for ODF3B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ODF3B Gene

Orthologs for ODF3B Gene

This gene was present in the common ancestor of animals.

Orthologs for ODF3B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Odf3b 35
  • 78.68 (n)
  • 73.82 (a)
Odf3b 16
Odf3b 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ODF3B 35
  • 99.34 (n)
  • 99.6 (a)
ODF3B 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Odf3b 35
  • 77.44 (n)
  • 73.28 (a)
cow
(Bos Taurus)
Mammalia MGC128071 36
  • 39 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ODF3B 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ODF3B 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ODF3B 36
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii odf3b 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8086 36
  • 4 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for ODF3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ODF3B Gene

ENSEMBL:
Gene Tree for ODF3B (if available)
TreeFam:
Gene Tree for ODF3B (if available)

Paralogs for ODF3B Gene

Paralogs for ODF3B Gene

(4) SIMAP similar genes for ODF3B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ODF3B: view

Variants for ODF3B Gene

Sequence variations from dbSNP and Humsavar for ODF3B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs131792 -- 50,533,425(-) ctcgg(C/T)tcttg upstream-variant-2KB
rs131793 -- 50,533,366(-) ttaac(C/T)tggtg upstream-variant-2KB
rs131794 -- 50,533,323(-) acaGT(G/T)TGTAA upstream-variant-2KB
rs131795 -- 50,533,277(-) TTTTT(A/T)AAAGA upstream-variant-2KB
rs131796 -- 50,533,210(-) TTTTT(-/T/TCTTTT)CTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ODF3B Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
nsv914525 CNV Loss 21882294
dgv5062n71 CNV Loss 21882294
nsv834238 CNV Loss 17160897
nsv471224 CNV Loss 18288195
nsv914542 CNV Loss 21882294
nsv914543 CNV Loss 21882294
dgv5064n71 CNV Loss 21882294
dgv5065n71 CNV Loss 21882294
nsv834239 CNV Loss 17160897
dgv1422e1 CNV Complex 17122850
dgv5066n71 CNV Loss 21882294
nsv914554 CNV Loss 21882294
nsv829340 CNV Gain 20364138
dgv5067n71 CNV Loss 21882294
nsv914556 CNV Loss 21882294

Variation tolerance for ODF3B Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ODF3B Gene

HapMap Linkage Disequilibrium report
ODF3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF3B Gene

Disorders for ODF3B Gene

Relevant External Links for ODF3B

Genetic Association Database (GAD)
ODF3B
Human Genome Epidemiology (HuGE) Navigator
ODF3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ODF3B

No disorders were found for ODF3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ODF3B Gene

Publications for ODF3B Gene

  1. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 48 67
  2. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  3. Seventy-five genetic loci influencing the human red blood cell. (PMID: 23222517) van der Harst P. … Chambers J.C. (Nature 2012) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3

Products for ODF3B Gene

Sources for ODF3B Gene

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