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Aliases for ODF3 Gene

Aliases for ODF3 Gene

  • Outer Dense Fiber Of Sperm Tails 3 2 3
  • Transcript Induced In Spermiogenesis Protein 50 3 4
  • Cancer/Testis Antigen 135 2 3
  • SHIPPO1 3 4
  • TISP50 3 4
  • Outer Dense Fiber Of Sperm Tails Protein 3 4
  • Sperm Tail Protein SHIPPO 1 4
  • Sperm Tail Protein SHIPPO1 3
  • CT135 3

External Ids for ODF3 Gene

Previous GeneCards Identifiers for ODF3 Gene

  • GC11M000109
  • GC11M000998
  • GC11P000186
  • GC11P000016

Summaries for ODF3 Gene

Entrez Gene Summary for ODF3 Gene

  • ODF3 is a component of sperm flagella outer dense fibers, which add stiffness, elastic recoil, and protection against shearing forces during sperm movement.[supplied by OMIM, Apr 2004]

GeneCards Summary for ODF3 Gene

ODF3 (Outer Dense Fiber Of Sperm Tails 3) is a Protein Coding gene. An important paralog of this gene is ODF3L1.

UniProtKB/Swiss-Prot for ODF3 Gene

  • Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF3 Gene

Genomics for ODF3 Gene

Regulatory Elements for ODF3 Gene

Genomic Location for ODF3 Gene

Chromosome:
11
Start:
196,641 bp from pter
End:
200,261 bp from pter
Size:
3,621 bases
Orientation:
Plus strand

Genomic View for ODF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ODF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF3 Gene

Proteins for ODF3 Gene

  • Protein details for ODF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PU9-ODF3A_HUMAN
    Recommended name:
    Outer dense fiber protein 3
    Protein Accession:
    Q96PU9
    Secondary Accessions:
    • B7ZLT0
    • Q69YX0

    Protein attributes for ODF3 Gene

    Size:
    254 amino acids
    Molecular mass:
    27710 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Shippo is a Japanese word for tail

    Alternative splice isoforms for ODF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ODF3 Gene

Proteomics data for ODF3 Gene at MOPED

Post-translational modifications for ODF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODF3 Gene

No data available for DME Specific Peptides for ODF3 Gene

Domains & Families for ODF3 Gene

Protein Domains for ODF3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ODF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PU9

UniProtKB/Swiss-Prot:

ODF3A_HUMAN :
  • Belongs to the ODF3 family.
  • Contains 2 STPGR (Sperm-tail PG-rich) repeats.
Family:
  • Belongs to the ODF3 family.
Similarity:
  • Contains 2 STPGR (Sperm-tail PG-rich) repeats.
genes like me logo Genes that share domains with ODF3: view

No data available for Gene Families for ODF3 Gene

Function for ODF3 Gene

Molecular function for ODF3 Gene

UniProtKB/Swiss-Prot Function:
Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail

Phenotypes for ODF3 Gene

GenomeRNAi human phenotypes for ODF3:
genes like me logo Genes that share phenotypes with ODF3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ODF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ODF3 Gene

Localization for ODF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODF3 Gene

Cytoplasm. Note=Expressed in the cytoplasmic lobe of spermatids. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ODF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001520 outer dense fiber IEA --
genes like me logo Genes that share ontologies with ODF3: view

No data available for Subcellular locations from COMPARTMENTS for ODF3 Gene

Pathways & Interactions for ODF3 Gene

SuperPathways for ODF3 Gene

No Data Available

Interacting Proteins for ODF3 Gene

Gene Ontology (GO) - Biological Process for ODF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ODF3: view

No data available for Pathways by source and SIGNOR curated interactions for ODF3 Gene

Drugs & Compounds for ODF3 Gene

No Compound Related Data Available

Transcripts for ODF3 Gene

mRNA/cDNA for ODF3 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ODF3 Gene

Outer dense fiber of sperm tails 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ODF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF3 Gene

No ASD Table

Relevant External Links for ODF3 Gene

GeneLoc Exon Structure for
ODF3
ECgene alternative splicing isoforms for
ODF3

Expression for ODF3 Gene

mRNA expression in normal human tissues for ODF3 Gene

mRNA differential expression in normal tissues according to GTEx for ODF3 Gene

This gene is overexpressed in Testis (x47.4).

Protein differential expression in normal tissues from HIPED for ODF3 Gene

This gene is overexpressed in Testis (54.6) and Ovary (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ODF3 Gene



SOURCE GeneReport for Unigene cluster for ODF3 Gene Hs.350949

mRNA Expression by UniProt/SwissProt for ODF3 Gene

Q96PU9-ODF3A_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with ODF3: view

Protein tissue co-expression partners for ODF3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ODF3 Gene

Orthologs for ODF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ODF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ODF3 35
  • 90.29 (n)
  • 92.52 (a)
ODF3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ODF3 35
  • 89.11 (n)
  • 93.31 (a)
ODF3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Odf3 35
  • 88.98 (n)
  • 93.7 (a)
Odf3 16
Odf3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ODF3 35
  • 99.34 (n)
  • 98.82 (a)
ODF3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Odf3 35
  • 88.98 (n)
  • 92.52 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ODF3 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 44 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ODF3 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia odf3 35
  • 56.52 (n)
  • 55.34 (a)
Str.3041 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52679 35
zebrafish
(Danio rerio)
Actinopterygii odf3b 35
  • 56.97 (n)
  • 52.59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5039 35
fruit fly
(Drosophila melanogaster)
Insecta CG8086 36
  • 5 (a)
ManyToMany
Species with no ortholog for ODF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ODF3 Gene

ENSEMBL:
Gene Tree for ODF3 (if available)
TreeFam:
Gene Tree for ODF3 (if available)

Paralogs for ODF3 Gene

Paralogs for ODF3 Gene

(3) SIMAP similar genes for ODF3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ODF3: view

Variants for ODF3 Gene

Sequence variations from dbSNP and Humsavar for ODF3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2686892 -- 195,218(+) TGAGG(C/T)GGGAG upstream-variant-2KB
rs2948215 -- 195,109(+) CCACG(C/T)AGGCA upstream-variant-2KB
rs2979427 -- 195,982(-) CAAGG(C/T)CCCCC upstream-variant-2KB
rs3741411 -- 199,256(+) TGCAC(A/G)GGCAC intron-variant
rs3802984 -- 197,337(+) TGGAG(A/G)CCCCA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ODF3 Gene

Variant ID Type Subtype PubMed ID
dgv910n71 CNV Gain 21882294
esv22231 CNV Gain 19812545
nsv896436 CNV Gain 21882294
nsv896437 CNV Loss 21882294
dgv911n71 CNV Gain 21882294
nsv467630 CNV Gain 19166990
nsv522596 CNV Gain 19592680
nsv467631 CNV Gain 19166990
nsv896439 CNV Loss 21882294

Variation tolerance for ODF3 Gene

Residual Variation Intolerance Score: 80.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ODF3 Gene

HapMap Linkage Disequilibrium report
ODF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF3 Gene

Disorders for ODF3 Gene

Relevant External Links for ODF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ODF3
genes like me logo Genes that share disorders with ODF3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ODF3 Gene

Publications for ODF3 Gene

  1. Molecular cloning and characterization of a complementary DNA encoding sperm tail protein SHIPPO 1. (PMID: 11870087) Egydio de Carvalho C. … Nishimune Y. (Biol. Reprod. 2002) 2 23 67
  2. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PMID: 24026423) Shameer K. … Kullo I.J. (Hum. Genet. 2014) 67
  3. Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient. (PMID: 23096689) Ghafouri-Fard S. … Modarressi M.H. (Genet. Mol. Res. 2012) 67
  4. A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. (PMID: 21460842) Cha P.C. … Nakamura Y. (Nat. Genet. 2011) 67
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 67

Products for ODF3 Gene

Sources for ODF3 Gene

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