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ODF2L Gene

protein-coding GIFtS: 43

GC01M086527

outer dense fiber of sperm tails 2-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA1229 ^¹, ², ³
MGC111060 ^²
RP5-977L11.1 ^²
dJ977L11.1 ^²

Descriptions
outer dense fiber of sperm tails 2-like ^²

External Ids
HGNC: 29225¹
Entrez Gene: 57489²
UniProtKB: Q9ULJ1³
Ensembl: ENSG00000122417⁷

Search outside databases for aliases for ODF2L gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ODF2L gene

Entrez Gene cytogenetic band: 1p22.3 Ensembl cytogenetic band: 1p22.3 HGNC cytogenetic band: 1p22.3

ODF2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M086527: (about GC identifiers)

Start:	86,581,341 bp from pter
End:	86,634,591 bp from pter
Size:	53,251 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ODF2L_HUMAN, Q9ULJ1 (See protein sequence)

Recommended Name: Outer dense fiber protein 2-like

Size: 636 amino acids; 73728 Da

Sequence caution: Sequence=AAH29420.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.

Potential poly-A sequence; Sequence=AAH47368.1; Type=Erroneous termination; Positions=397;

Note=Translated as Glu;

Secondary accessions: Q05C40 Q5BJG5 Q5TBX3 Q5TBX4 Q86X31

Alternative splicing: 3 isoforms: Q9ULJ1-1 Q9ULJ1-2 Q9ULJ1-3

REFSEQ proteins (2 alternative transcripts):

NP_001007023.1 NP_065780.1

ENSEMBL proteins:

ENSP00000320165 ENSP00000359597 ENSP00000294678 ENSP00000378219 ENSP00000359600 ENSP00000359598

ENSP00000378220 ENSP00000359599

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (ODF2L)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for ODF2L:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ODF2L

Assays for ODF2L:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9ULJ1

UniProtKB/Swiss-Prot: ODF2L_HUMAN, Q9ULJ1

Similarity: Belongs to the ODF2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ODF2L)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): XM_030665

Applied Biosystems Silencer® siRNAs for ODF2L

Sigma-Aldrich siRNA for ODF2L

Sigma-Aldrich shRNA for ODF2L

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ODF2L
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001007022
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001007022
untagged cDNA clones in CMV expression vector (see all 4): BC009779

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020729

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ODF2L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ODF2L)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): XM_030665

Sigma-Aldrich siRNA for ODF2L

Sigma-Aldrich shRNA for ODF2L

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001007022 NM_020729

REFSEQ mRNAs for ODF2L gene (2 alternative transcripts):

NM_001007022.1 NM_020729.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001007022 NM_020729

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001007022
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001007022
                                 untagged cDNA clones in CMV expression vector (see all 4): BC009779

Additional cDNA sequence:

AB033055.1 AK302792.1 AK303209.1 AK308351.1 BC009779.1 BC012579.1 BC026105.2 BC029420.1

BC047368.1 BC091490.1 CR591511.1

22 DOTS entries:

DT.99939491 DT.100675677 DT.92428840 DT.100792291 DT.87014957 DT.99977796 DT.102825547 DT.121445945

DT.40115136 DT.443632 DT.75129094 DT.70105106 DT.92428842 DT.95087540 DT.99949602 DT.121445947

DT.121446015 DT.95072764 DT.442048 DT.443633 DT.99934490 DT.95347735

24/172 AceView cDNA sequences (see all 172 ):

BM983457 CA446491 BU686861 AI382078 AI623670 BX955119 AI886345 AI473444

BE674715 BM971230 AW452022 CA949998 CB148065 AA825161 CR591511 AW172516

BQ028973 AI376178 BQ894001 AA301374 CF145486 AA521186 AA552255 BM150300

highest scoring ESTs for ODF2L:

AI817989 AB033055 AI948502 AL703770 AW274155 AW449997 AW452022 BC009779 BC012579 BC029420

Unigene Cluster for ODF2L:

Outer dense fiber of sperm tails 2-like

Hs.149360 [show with all ESTs]

Unigene Representative Sequence: AB033055

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ODF2L (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14
SP1:											-		-		-										-
SP2:													-
SP3:
SP4:											-		-		-
SP5:											-		-

About this scheme

ECgene alternative splicing isoforms for ODF2L

8 Ensembl transcripts including schematic representations:

ENST00000317336 ENST00000370566 ENST00000294678 ENST00000394731 ENST00000359242 ENST00000370567

ENST00000394733 ENST00000370568

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ODF2L expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ODF2L

¹ / ² / ³

16 probe-sets matching ODF2L gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53696_at²^{, 3}	U95-C	1	1.00	1.00	0.49	1.44	AA193342	0.20	1.00	0.72	1
57504_at²^{, 3}	U95-C	1	1.00	1.00	0.10	0.94	AA772124	0.60	1.00	0.82	1
87488_at²^{, 3}	U95-E	1	1.00	1.00	0.84	1.02	AI817989	1.00	1.00	1.00	1
46650_at²^{, 3}	U95-B	1	1.00	1.00	0.88	0.64	AI741045	0.60	1.00	0.82	1
89458_s_at²^{, 3}	U95-D	1	1.00	1.00	0.89	1.41	AI377396	0.40	1.00	0.76	1
72045_at²^{, 3}	U95-E	2	1.00	0.97	0.78	1.03	AI282691	0.60	1.00	0.82	1
79430_r_at²^{, 3}	U95-E	1	0.94	1.00	0.87	0.71	AI682783	0.60	1.00	0.82	1
89461_r_at²^{, 3}	U95-D	1	0.94	1.00	0.48	0.45	AI377396	0.40	1.00	0.76	1
231909_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB033055	0.80	1.00	0.91	1
230926_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW452022	0.80	1.00	0.91	1
228577_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI338465	0.40	1.00	0.76	1
237420_at²	U133-B	1	0.91	1.00	--	--	--	--	--	--	--
231909_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230926_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228577_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
237420_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks ODF2L for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCACGTGTAT

SOURCE GeneReport for Unigene cluster: Hs.149360

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ODF2L gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ODF2L¹	--	outer dense fiber of sperm tails 2-like	90.15(n) 84.29(a)	490179 XM_547300.2 XP_547300.2
cow (Bos taurus)	ODF2L¹	--	outer dense fiber of sperm tails 2-like	89.82(n) 83(a)	533508 NM_001075993.1 NP_001069461.1
rat (Rattus norvegicus)	Odf2l¹	--	outer dense fiber of sperm tails 2-like	79.44(n) 72.91(a)	685425 XM_001063750.1 XP_001063750.1
mouse (Mus musculus)	Odf2l^{1, 5}	3 (69.00 cM)⁵	outer dense fiber of sperm tails 2-like^{1, 5}	80.24(n)¹ 75.81(a)¹	52184¹ NM_025714.2¹ NP_079990.1¹ AI428393⁵ AI835031⁵ (see all 15)
chicken (Gallus gallus)	ODF2L¹	--	outer dense fiber of sperm tails 2-like	59.72(n) 43.08(a)	424524 XM_422361.2 XP_422361.2

About this table Species with no ortholog for ODF2L

ENSEMBL Gene Tree for ODF2L

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ODF2L gene

ODF2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/266 NCBI SNPs in ODF2L are shown (see all 266 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 93)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6679600^1,2	A,C,F,H	86636030(+)	`GATACT/CTGAAT`	2	--	ng3¹		1		EU	112
	rs10873778^1,2	A,C,F,H	86636516(+)	`CAGTGG/TTATCA`	2	--	ng3¹		2		EU WA	230
	rs3737671^1,2	C,F,H	86634431(+)	`AGTCGG/TCTAGG`	2	--	ut5¹ ese³		9		EA EU WA	2326
	rs12403033^1,2	C,F,H	86635579(+)	`atggtT/Cttgta`	2	--	ng3¹		4		EU EA WA	392
	rs11799437^1,2	C,F,H	86634978(+)	`GAGATG/ACCTCC`	2	--	ng3¹		1		EU	110
--	rs1413432^1,2	A,C	86635848(+)	`tctgcC/Tattgt`	2	--	ng3¹		0	--	--	--	--
--	rs12032435^1,2	F,H	86620607(+)	`AAAAAC/TGGTTT`	2	R/H	mis¹		4		EU EA WA	406
	rs2390096^1,2	A,C	86625209(-)	`CGGTGC/TACCAG`	2	C/C	syn¹ ut5¹		0	--	--	--	--
	rs12742411^1,2	H	86586858(+)	`TAAAGT/GTTCAG`	2	--	ng5¹		4		EU EA WA	400
	rs12757699^1,2	H	86634304(+)	`CTTACG/ACCCCC`	2	--	ut5¹		3		EU EA	268

About this table

HapMap Linkage Disequilibrium images for ODF2L (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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6 PubMed articles for ODF2L gene:

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{2, 3, 4} Nagase T....Ohara O. (1999)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)⁴ Gregory S.G.... Bentley D.R. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)³ Bonaldo M.F....Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 57489	HGNC: 29225	AceView: KIAA1229	Ensembl:ENSG00000122417	euGenes: HUgn57489
ECgene: ODF2L	H-InvDB: ODF2L

(According to HUGE)
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HUGE: KIAA1229

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ODF2L
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ODF2L:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ODF2L-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ODF2L		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ODF2L		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ODF2L)
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Search Novus for antibodies for ODF2L

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ODF2L Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for ODF2L

Summaries
for ODF2L

Genomic Location
for ODF2L

Proteins
for ODF2L

Protein Domains/
Families
for ODF2L

Gene Function
for ODF2L

Pathways & Interactions
for ODF2L

Drugs & Compounds
for ODF2L

Transcripts
for ODF2L

Expression
for ODF2L

Orthologs
for ODF2L

Paralogs
for ODF2L

SNPs/Variants
for ODF2L

Disorders & Mutations
for ODF2L

Medical News
for ODF2L

Publications
for ODF2L

Search for ODF2L

Genome Databases showing ODF2L

Other Databases showing ODF2L

Specialized Databases showing ODF2L

Licensable Technologies
for ODF2L

Services
for ODF2L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ODF2L Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor ODF2L

Summariesfor ODF2L

Genomic Locationfor ODF2L

Proteinsfor ODF2L

Protein Domains/Familiesfor ODF2L

Gene Functionfor ODF2L

Pathways & Interactionsfor ODF2L

Drugs & Compoundsfor ODF2L

Transcriptsfor ODF2L

Expression for ODF2L

Orthologsfor ODF2L

Paralogsfor ODF2L

SNPs/Variantsfor ODF2L

Disorders & Mutationsfor ODF2L

Medical Newsfor ODF2L

Publicationsfor ODF2L

Search for ODF2L

Genome Databases showing ODF2L

Other Databases showing ODF2L

Specialized Databases showing ODF2L

Licensable Technologiesfor ODF2L

Servicesfor ODF2L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ODF2L

Summaries
for ODF2L

Genomic Location
for ODF2L

Proteins
for ODF2L

Protein Domains/
Families
for ODF2L

Gene Function
for ODF2L

Pathways & Interactions
for ODF2L

Drugs & Compounds
for ODF2L

Transcripts
for ODF2L

Expression
for ODF2L

Orthologs
for ODF2L

Paralogs
for ODF2L

SNPs/Variants
for ODF2L

Disorders & Mutations
for ODF2L

Medical News
for ODF2L

Publications
for ODF2L

Licensable Technologies
for ODF2L

Services
for ODF2L