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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ODF2L Gene

protein-coding   GIFtS: 46
GCID: GC01M086808

Outer Dense Fiber Of Sperm Tails 2-Like

  Search for ODF2L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Outer Dense Fiber Of Sperm Tails 2-Like1 2
RP5-977L11.12
dJ977L11.12
Outer Dense Fiber Protein 2-Like2
KIAA12293

External Ids:    HGNC: 292251   Entrez Gene: 574892   Ensembl: ENSG000001224177   UniProtKB: Q9ULJ13   

Export aliases for ODF2L gene to outside databases

Previous GC identifers: GC01M086527 GC01M084923


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ODF2L Gene: 
ODF2L (outer dense fiber of sperm tails 2-like) is a protein-coding gene. An important paralog of this gene is ODF2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ODF2L gene promoter:
         HFH-3   HOXA9   HOXA9B   Pbx1a   AML1a   FOXD3   AP-4   FOXI1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidODF2L promoter sequence
   Search SABiosciences Chromatin IP Primers for ODF2L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ODF2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

ODF2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ODF2L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M086808:  view genomic region     (about GC identifiers)

Start:
86,812,507 bp from pter      End:
86,862,025 bp from pter
Size:
49,519 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ODF2L_HUMAN, Q9ULJ1 (See protein sequence)
Recommended Name: Outer dense fiber protein 2-like  
Size: 636 amino acids; 73728 Da
Sequence caution: Sequence=AAH29420.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH47368.1; Type=Erroneous termination; Positions=397; Note=Translated as Glu;
Sequence=AK308351; Type=Frameshift; Positions=296; Sequence=BAA86543.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
Secondary accessions: A8MU56 B4E037 Q05C40 Q5BJG5 Q5TBX3 Q5TBX4 Q86X31
Alternative splicing: 6 isoforms:  Q9ULJ1-1   Q9ULJ1-2   Q9ULJ1-3   Q9ULJ1-4   Q9ULJ1-5   Q9ULJ1-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ODF2L: NX_Q9ULJ1

Explore proteomics data for ODF2L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULJ1

  • ODF2L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ODF2L Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001007023.2  NP_001171694.1  NP_001171695.1  NP_065780.2  

    ENSEMBL proteins: 
     ENSP00000359600   ENSP00000433092   ENSP00000359597   ENSP00000437043   ENSP00000294678  
     ENSP00000431920   ENSP00000433632   ENSP00000432834   ENSP00000378220   ENSP00000437292  
     ENSP00000432632   ENSP00000320165   ENSP00000359598   ENSP00000378219  

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    Cloud-Clone Corp. Proteins for ODF2L 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--

    ODF2L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR026099 Odf2-rel
     IPR026102 Odf2-like

    Graphical View of Domain Structure for InterPro Entry Q9ULJ1

    ProtoNet protein and cluster: Q9ULJ1

    UniProtKB/Swiss-Prot: ODF2L_HUMAN, Q9ULJ1
    Similarity: Belongs to the ODF2 family


    ODF2L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
         
    ODF2L for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ODF2L

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for ODF2L (Q9ULJ13 ENSP000003595984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIPOXQ9P0Z93, ENSP000003177214I2D: score=1 STRING: ENSP00000317721
    ERBB3P218603I2D: score=2 
    KIAA1377Q9P2H03I2D: score=2 
    PRSS23O950843I2D: score=2 
    PRSS35ENSP000003587144STRING: ENSP00000358714
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ODF2L

    Search CenterWatch for drugs/clinical trials and news about ODF2L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ODF2L gene (4 alternative transcripts): 
    NM_001007022.2  NM_001184765.1  NM_001184766.1  NM_020729.2  

    Unigene Cluster for ODF2L:

    Outer dense fiber of sperm tails 2-like
    Hs.149360  [show with all ESTs]
    Unigene Representative Sequence: AB033055
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000359242(uc001dll.2) ENST00000460698 ENST00000370566(uc001dlp.3 uc010osg.2 uc021opg.1 uc001dlq.2 uc009wcr.2)
    ENST00000462648 ENST00000294678(uc001dlm.2) ENST00000531412 ENST00000476054
    ENST00000473792 ENST00000524695 ENST00000472144 ENST00000463933 ENST00000534092
    ENST00000496592 ENST00000488879 ENST00000479890 ENST00000486557 ENST00000472368
    ENST00000480440
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ODF2L (see all 20):
    hsa-miR-148b* hsa-miR-520f hsa-miR-361-5p hsa-miR-513c hsa-miR-340 hsa-miR-548l hsa-miR-3658 hsa-miR-383
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    Additional mRNA sequence: 

    AB033055.1 AK302792.1 AK303209.1 AK308351.1 BC009779.1 BC012579.1 BC026105.2 BC029420.1 
    BC047368.1 BC091490.1 

    24 DOTS entries:

    DT.99939491  DT.100675677  DT.92428840  DT.406260  DT.100792291  DT.87014957  DT.99977796  DT.102825547 
    DT.121445945  DT.40115136  DT.443632  DT.75129094  DT.70105106  DT.92428842  DT.99949602  DT.121445947 
    DT.121446015  DT.95087540  DT.100008825  DT.442048  DT.443633  DT.95072764  DT.99934490  DT.95347735 

    24/172 AceView cDNA sequences (see all 172):

    AA301374 BU686861 AI382078 AI623670 AI376178 AW172516 AA825161 AA521186 
    BQ028973 AA552255 AW452022 AI886345 BM150300 CA446491 BQ894001 CB148065 
    BE674715 CR591511 CF145486 BX955119 BM971230 CA949998 AI473444 BM983457 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ODF2L (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                -     -     -                             -                                             
    SP2:                                      -                                                                                 
    SP3:                                                                                                                        
    SP4:                                -     -     -                                                                           
    SP5:                                -     -                                                                                 


    ECgene alternative splicing isoforms for ODF2L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ODF2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACGTGTAT
    ODF2L Expression
    About this image


    See ODF2L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ODF2L

    SOURCE GeneReport for Unigene cluster: Hs.149360
        SABiosciences Custom PCR Arrays for ODF2L
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ODF2L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ODF2L gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Odf2l1 , 5 outer dense fiber of sperm tails 2-like1, 5 70.83(n)1
    63.42(a)1
      3 (69.36 cM)5
    521841  NM_001162538.11  NP_001156010.11 
     1451185895 
    chicken
    (Gallus gallus)
    Aves ODF2L1 outer dense fiber of sperm tails 2-like 58.07(n)
    41.54(a)
      424524  XM_422361.3  XP_422361.3 
    lizard
    (Anolis carolinensis)
    Reptilia ODF2L6
    Uncharacterized protein
    42(a)
    1 ↔ 1
    4(97891543-97948965)


    ENSEMBL Gene Tree for ODF2L (if available)
    TreeFam Gene Tree for ODF2L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ODF2L gene
    ODF22  
    1 SIMAP similar gene for ODF2L using alignment to 12 protein entries:     ODF2L_HUMAN (see all proteins):
    ODF2

    ODF2L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/959 SNPs in ODF2L are shown (see all 959)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456225771,2
    C--86812028(+) AAGCAC/TGGAGG 2 -- int10--------
    rs1164342841,2
    C,F--86812044(+) TCCAGG/AAGCCA 2 -- int11Minor allele frequency- A:0.01WA 118
    rs1381301731,2
    --86812089(+) ATAACA/GTAGAT 2 -- int10--------
    rs118047331,2
    C,F,H--86812108(+) AAAACA/GTTTAC 2 -- int13Minor allele frequency- G:0.07NA WA 124
    rs618040601,2
    C,F--86812174(+) TCTTTT/CAGTAC 2 -- int17Minor allele frequency- C:0.22WA NA EA 366
    rs1914993771,2
    --86812213(+) GGCCTC/TGCTGA 2 -- int10--------
    rs1836515161,2
    --86812387(+) TTGTGA/GTAGTC 2 -- int10--------
    rs127496371,2
    C,F--86812414(+) TATCTA/GAAGCT 2 -- int15Minor allele frequency- G:0.11NA WA 126
    rs765148991,2
    C--86812510(+) GGTAA-/ASMAAA 4 -- ut310--------
    rs743477421,2
    C--86812511(+) GTAAG-/ACAAAT 2 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for ODF2L (86812507 - 86862025 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ODF2L:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714363CNV Deletion23290073
    esv2657167CNV Deletion23128226
    esv2714374CNV Deletion23290073
    nsv871081CNV Loss21882294
    nsv871866CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ODF2L for disorders           About MalaCards

    ODF2L for disorders           About GeneDecksing

    Genetic Association Database (GAD): ODF2L

    Export disorders for ODF2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ODF2L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ODF2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    3. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    4. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57489 HGNC: 29225 AceView: KIAA1229 Ensembl:ENSG00000122417 euGenes: HUgn57489
    ECgene: ODF2L H-InvDB: ODF2L

    (According to HUGE)
    About This Section
    HUGE: KIAA1229

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ODF2L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ODF2L gene:
    Search GeneIP for patents involving ODF2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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