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Aliases for ODF2 Gene

Aliases for ODF2 Gene

  • Outer Dense Fiber Of Sperm Tails 2 2 3
  • Cancer/Testis Antigen 134 2 3
  • ODF84 3 6
  • Outer Dense Fiber Of Sperm Tails Protein 2 4
  • Outer Dense Fiber Of Sperm Tails, 84-KD 3
  • Outer Dense Fibre Of Sperm Tails 2 2
  • Sperm Tail Structural Protein 3
  • Outer Dense Fiber Protein 2 3
  • Cenexin 1 3
  • Cenexin 4
  • ODF2/1 3
  • ODF2/2 3
  • CT134 3

External Ids for ODF2 Gene

Previous GeneCards Identifiers for ODF2 Gene

  • GC09P122333
  • GC09P122864
  • GC09P124672
  • GC09P126595
  • GC09P126596
  • GC09P128297
  • GC09P130258
  • GC09P131218
  • GC09P100831

Summaries for ODF2 Gene

Entrez Gene Summary for ODF2 Gene

  • The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]

GeneCards Summary for ODF2 Gene

ODF2 (Outer Dense Fiber Of Sperm Tails 2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is ODF2L.

UniProtKB/Swiss-Prot for ODF2 Gene

  • Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.

Gene Wiki entry for ODF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF2 Gene

Genomics for ODF2 Gene

Regulatory Elements for ODF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ODF2 Gene

Start:
128,455,155 bp from pter
End:
128,501,292 bp from pter
Size:
46,138 bases
Orientation:
Plus strand

Genomic View for ODF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ODF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF2 Gene

Proteins for ODF2 Gene

  • Protein details for ODF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BJF6-ODFP2_HUMAN
    Recommended name:
    Outer dense fiber protein 2
    Protein Accession:
    Q5BJF6
    Secondary Accessions:
    • B1AND3
    • B4DRK4
    • B4DX73
    • B4DZ02
    • E7EWL2
    • F5H6J4
    • O14721
    • O60631
    • Q1W2J6
    • Q6UN26
    • Q7Z5I6
    • Q96FN2

    Protein attributes for ODF2 Gene

    Size:
    829 amino acids
    Molecular mass:
    95401 Da
    Quaternary structure:
    • Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the microtubule network. Interacts via its C-terminus with PLK1. Interacts with ODF1 (By similarity).
    SequenceCaution:
    • Sequence=AAC08409.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ODF2 Gene

neXtProt entry for ODF2 Gene

Proteomics data for ODF2 Gene at MOPED

Post-translational modifications for ODF2 Gene

  • Tyrosine phosphorylated.
  • Ubiquitination at Lys204, Lys210, Lys223, Lys253, Lys259, and Lys295
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ODF2 Gene

Domains for ODF2 Gene

Protein Domains for ODF2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5BJF6

UniProtKB/Swiss-Prot:

ODFP2_HUMAN :
  • Q5BJF6
Family:
  • Belongs to the ODF2 family.
genes like me logo Genes that share domains with ODF2: view

No data available for Gene Families for ODF2 Gene

Function for ODF2 Gene

Molecular function for ODF2 Gene

GENATLAS Biochemistry: outer dense fiber protein 2,component of the filamentous structure of the sperm tail,expressed in round spermatids extending to about half the principal piece of tail sperm,involved in sperm tail function and motility
UniProtKB/Swiss-Prot Function: Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.

Gene Ontology (GO) - Molecular Function for ODF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 10072582
GO:0005515 protein binding IPI 16980960
GO:0017137 Rab GTPase binding IPI 17646400
genes like me logo Genes that share ontologies with ODF2: view
genes like me logo Genes that share phenotypes with ODF2: view

Animal Model Products

CRISPR Products

miRNA for ODF2 Gene

miRTarBase miRNAs that target ODF2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ODF2

Clone Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ODF2 Gene

Localization for ODF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODF2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ODF2 Gene COMPARTMENTS Subcellular localization image for ODF2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ODF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0001520 outer dense fiber IEA --
GO:0005634 nucleus IDA 21630459
GO:0005813 centrosome IDA --
GO:0005814 centriole IDA 17646400
genes like me logo Genes that share ontologies with ODF2: view

Pathways for ODF2 Gene

genes like me logo Genes that share pathways with ODF2: view

Interacting Proteins for ODF2 Gene

Selected Interacting proteins: Q5BJF6-ODFP2_HUMAN for ODF2 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for ODF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0007275 multicellular organismal development IEA --
GO:0007286 spermatid development IEA --
genes like me logo Genes that share ontologies with ODF2: view

Transcripts for ODF2 Gene

Unigene Clusters for ODF2 Gene

Outer dense fiber of sperm tails 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ODF2

Clone Products

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - -
SP13: - - - -
SP14:
SP15: - - - - - - - - - -
SP16: - - - - - - - - - - -
SP17: - - - - - - - - - - - - - -
SP18:
SP19: - - - - - - - - -
SP20: - - - - - - - -
SP21: - - - -
SP22:
SP23:
SP24:
SP25:

ExUns: 9f ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c · 23d ^ 24a · 24b · 24c ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: -
SP23: - - - -
SP24:
SP25: - -

ExUns: 24d ^ 25 ^ 26a · 26b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for ODF2 Gene

GeneLoc Exon Structure for
ODF2
ECgene alternative splicing isoforms for
ODF2

Expression for ODF2 Gene

mRNA expression in normal human tissues for ODF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ODF2 Gene

This gene is overexpressed in Testis (10.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ODF2 Gene

SOURCE GeneReport for Unigene cluster for ODF2 Gene Hs.129055

mRNA Expression by UniProt/SwissProt for ODF2 Gene

Q5BJF6-ODFP2_HUMAN
Tissue specificity: Testis-specific (at protein level). Highly expressed in cytoplasm of step 2 round spermatids. Detected in the middle piece and extends to about half the principal piece of the sperm tails.
genes like me logo Genes that share expressions with ODF2: view

In Situ Assay Products

Orthologs for ODF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ODF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODF2 35
  • 99.18 (n)
  • 99.44 (a)
ODF2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ODF2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ODF2 35
  • 93.02 (n)
  • 97.98 (a)
ODF2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Odf2 35
  • 90.6 (n)
  • 97.39 (a)
Odf2 16
Odf2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ODF2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves ODF2 35
  • 71.29 (n)
  • 71.62 (a)
ODF2 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.13486 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15979 35
zebrafish
(Danio rerio)
Actinopterygii odf2a 35
  • 58 (n)
  • 52.25 (a)
odf2a 36
  • 48 (a)
OneToMany
odf2b 36
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for ODF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ODF2 Gene

ENSEMBL:
Gene Tree for ODF2 (if available)
TreeFam:
Gene Tree for ODF2 (if available)

Paralogs for ODF2 Gene

Paralogs for ODF2 Gene

genes like me logo Genes that share paralogs with ODF2: view

Variants for ODF2 Gene

Sequence variations from dbSNP and Humsavar for ODF2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1133750 -- 128,500,678(+) TAAGC(A/G)CCATC utr-variant-3-prime
rs3088209 -- 128,501,171(-) AAGCA(A/G)TCCTT utr-variant-3-prime
rs3192738 -- 128,494,768(+) TTTTT(C/T)TTGGC intron-variant, utr-variant-3-prime
rs3814529 -- 128,460,828(+) GAGCA(A/G)CAGCA intron-variant
rs3924786 -- 128,485,347(+) GCCCT(A/T)TTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ODF2 Gene

Variant ID Type Subtype PubMed ID
dgv8294n71 CNV Loss 21882294
nsv893898 CNV Loss 21882294
esv2739072 CNV Deletion 23290073
esv2150257 CNV Deletion 18987734
esv1639805 CNV Deletion 17803354

Relevant External Links for ODF2 Gene

HapMap Linkage Disequilibrium report
ODF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF2 Gene

Disorders for ODF2 Gene

Relevant External Links for ODF2

Genetic Association Database (GAD)
ODF2
Human Genome Epidemiology (HuGE) Navigator
ODF2
genes like me logo Genes that share disorders with ODF2: view

No data available for UniProtKB/Swiss-Prot for ODF2 Gene

Publications for ODF2 Gene

  1. Human outer dense fiber gene, ODF2, localizes to chromosome 9q34. (PMID: 10072582) Shao X. … van der Hoorn F.A. (Cytogenet. Cell Genet. 1998) 2 3
  2. Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa. (PMID: 10381817) Petersen C. … Hoyer-Fender S. (Mol. Hum. Reprod. 1999) 3 4
  3. Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27. (PMID: 9045620) Shao X. … van der Hoorn F.A. (J. Biol. Chem. 1997) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. (PMID: 16966375) Soung N.-K. … Lee K.S. (Mol. Cell. Biol. 2006) 3 4

Products for ODF2 Gene

Sources for ODF2 Gene

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