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Aliases for ODF2 Gene

Aliases for ODF2 Gene

  • Outer Dense Fiber Of Sperm Tails 2 2 3 5
  • Cancer/Testis Antigen 134 2 3
  • Cenexin 2 4
  • Testis Tissue Sperm-Binding Protein Li 51e 3
  • Outer Dense Fiber Of Sperm Tails Protein 2 4
  • Outer Dense Fiber Of Sperm Tails, 84-KD 3
  • Outer Dense Fibre Of Sperm Tails 2 2
  • Sperm Tail Structural Protein 3
  • Outer Dense Fiber Protein 2 3
  • Cenexin 1 3
  • ODF2/1 3
  • ODF2/2 3
  • CT134 3
  • ODF84 3

External Ids for ODF2 Gene

Previous GeneCards Identifiers for ODF2 Gene

  • GC09P122333
  • GC09P122864
  • GC09P124672
  • GC09P126595
  • GC09P126596
  • GC09P128297
  • GC09P130258
  • GC09P131218
  • GC09P100831

Summaries for ODF2 Gene

Entrez Gene Summary for ODF2 Gene

  • The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]

GeneCards Summary for ODF2 Gene

ODF2 (Outer Dense Fiber Of Sperm Tails 2) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include structural molecule activity and Rab GTPase binding. An important paralog of this gene is ODF2L.

UniProtKB/Swiss-Prot for ODF2 Gene

  • Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.

Gene Wiki entry for ODF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF2 Gene

Genomics for ODF2 Gene

Regulatory Elements for ODF2 Gene

Enhancers for ODF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F128631 0.9 Ensembl ENCODE 11.2 +179.9 179868 6.9 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207 LOC101929270 LOC101929314 SPOUT1 PKN3 CDK9 LOC100506100 ZDHHC12 ODF2 LOC100129352 RNU7-171P
GH09F127867 1 ENCODE 5.7 -587.3 -587295 1.1 CTCF ZBTB33 ST6GALNAC6 LOC102723566 FPGS PTRH1 TTC16 ODF2 MIR4672 ENG
GH09F127860 1.1 FANTOM5 ENCODE 5 -593.3 -593297 3.6 HDGF ATF1 PKNOX1 MLX ZNF121 ELK1 GATA2 KDM4B ZNF263 NCOA1 ST6GALNAC6 LOC102723566 FPGS PTRH1 TTC16 CDK9 TOR2A FAM129B CERCAM ODF2
GH09F128454 1 ENCODE 0.8 +1.2 1170 2.8 HDGF PKNOX1 ATF1 CREB3L1 ARID4B SIN3A ZNF2 GLIS2 ELK1 ZNF143 LOC101929314 ENSG00000273186 SPOUT1 CDK9 PTRH1 LOC101929270 ODF2 PIR39360
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ODF2 on UCSC Golden Path with GeneCards custom track

Promoters for ODF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001315161 1245 1601 HDGF PKNOX1 ATF1 CREB3L1 ARID4B SIN3A ZNF2 GLIS2 ELK1 KLF7

Genomic Location for ODF2 Gene

Chromosome:
9
Start:
128,455,155 bp from pter
End:
128,501,292 bp from pter
Size:
46,138 bases
Orientation:
Plus strand

Genomic View for ODF2 Gene

Genes around ODF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF2 Gene

Proteins for ODF2 Gene

  • Protein details for ODF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BJF6-ODFP2_HUMAN
    Recommended name:
    Outer dense fiber protein 2
    Protein Accession:
    Q5BJF6
    Secondary Accessions:
    • B1AND3
    • B4DRK4
    • B4DX73
    • B4DZ02
    • E7EWL2
    • F5H6J4
    • O14721
    • O60631
    • Q1W2J6
    • Q6UN26
    • Q7Z5I6
    • Q96FN2

    Protein attributes for ODF2 Gene

    Size:
    829 amino acids
    Molecular mass:
    95401 Da
    Quaternary structure:
    • Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the microtubule network. Interacts via its C-terminus with PLK1 (PubMed:16966375). Interacts with ODF1 (By similarity). Interacts with MARK4; the interaction is required for localization of ODF2 to centrioles (PubMed:23400999).
    SequenceCaution:
    • Sequence=AAC08409.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ODF2 Gene

neXtProt entry for ODF2 Gene

Post-translational modifications for ODF2 Gene

  • Tyrosine phosphorylated.
  • Ubiquitination at Lys 204, Lys 210, Lys 223, Lys 253, Lys 259, and Lys 295
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ODF2 Gene

Domains & Families for ODF2 Gene

Protein Domains for ODF2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5BJF6

UniProtKB/Swiss-Prot:

ODFP2_HUMAN :
  • Belongs to the ODF2 family.
Family:
  • Belongs to the ODF2 family.
genes like me logo Genes that share domains with ODF2: view

No data available for Gene Families for ODF2 Gene

Function for ODF2 Gene

Molecular function for ODF2 Gene

GENATLAS Biochemistry:
outer dense fiber protein 2,component of the filamentous structure of the sperm tail,expressed in round spermatids extending to about half the principal piece of tail sperm,involved in sperm tail function and motility
UniProtKB/Swiss-Prot Function:
Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.

Gene Ontology (GO) - Molecular Function for ODF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 10072582
GO:0005515 protein binding IPI 16980960
genes like me logo Genes that share ontologies with ODF2: view
genes like me logo Genes that share phenotypes with ODF2: view

Animal Model Products

miRNA for ODF2 Gene

miRTarBase miRNAs that target ODF2

Clone Products

  • Addgene plasmids for ODF2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODF2 Gene

Localization for ODF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODF2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles. {ECO:0000250 UniProtKB:A3KGV1}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ODF2 Gene COMPARTMENTS Subcellular localization image for ODF2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for ODF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0001520 outer dense fiber IEA --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with ODF2: view

Pathways & Interactions for ODF2 Gene

genes like me logo Genes that share pathways with ODF2: view

Interacting Proteins for ODF2 Gene

Gene Ontology (GO) - Biological Process for ODF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007286 spermatid development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ODF2: view

No data available for SIGNOR curated interactions for ODF2 Gene

Transcripts for ODF2 Gene

Unigene Clusters for ODF2 Gene

Outer dense fiber of sperm tails 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for ODF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - -
SP13: - - - -
SP14:
SP15: - - - - - - - - - -
SP16: - - - - - - - - - - -
SP17: - - - - - - - - - - - - - -
SP18:
SP19: - - - - - - - - -
SP20: - - - - - - - -
SP21: - - - -
SP22:
SP23:
SP24:
SP25:

ExUns: 9f ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c · 23d ^ 24a · 24b · 24c ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: -
SP23: - - - -
SP24:
SP25: - -

ExUns: 24d ^ 25 ^ 26a · 26b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for ODF2 Gene

GeneLoc Exon Structure for
ODF2
ECgene alternative splicing isoforms for
ODF2

Expression for ODF2 Gene

mRNA expression in normal human tissues for ODF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ODF2 Gene

This gene is overexpressed in Testis (x10.5).

Protein differential expression in normal tissues from HIPED for ODF2 Gene

This gene is overexpressed in Nasal epithelium (38.0) and Testis (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ODF2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ODF2 Gene:

ODF2

SOURCE GeneReport for Unigene cluster for ODF2 Gene:

Hs.129055

mRNA Expression by UniProt/SwissProt for ODF2 Gene:

Q5BJF6-ODFP2_HUMAN
Tissue specificity: Testis-specific (at protein level). Highly expressed in cytoplasm of step 2 round spermatids. Detected in the middle piece and extends to about half the principal piece of the sperm tails.
genes like me logo Genes that share expression patterns with ODF2: view

Primer Products

No data available for Protein tissue co-expression partners for ODF2 Gene

Orthologs for ODF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ODF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODF2 34 35
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia ODF2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ODF2 34 35
  • 93.02 (n)
mouse
(Mus musculus)
Mammalia Odf2 34 16 35
  • 90.6 (n)
oppossum
(Monodelphis domestica)
Mammalia ODF2 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves ODF2 34 35
  • 71.29 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15979 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13486 34
zebrafish
(Danio rerio)
Actinopterygii odf2a 34 35
  • 58 (n)
odf2b 35
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for ODF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ODF2 Gene

ENSEMBL:
Gene Tree for ODF2 (if available)
TreeFam:
Gene Tree for ODF2 (if available)

Paralogs for ODF2 Gene

Paralogs for ODF2 Gene

genes like me logo Genes that share paralogs with ODF2: view

Variants for ODF2 Gene

Sequence variations from dbSNP and Humsavar for ODF2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10116341 -- 128,496,535(+) TGACC(C/G)TTCTC intron-variant
rs10481648 -- 128,474,640(+) tcagc(A/G)acaga intron-variant
rs10591401 -- 128,466,645(+) TTCCC(-/AT)ATATA intron-variant
rs10732396 -- 128,488,286(+) CAGGC(A/G)TGGAG intron-variant
rs10733691 -- 128,468,142(+) TCATA(C/G)AATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ODF2 Gene

Variant ID Type Subtype PubMed ID
esv1639805 CNV deletion 17803354
esv2150257 CNV deletion 18987734
esv2739072 CNV deletion 23290073
esv3545491 CNV deletion 23714750
esv3621810 CNV loss 21293372
nsv1051081 CNV gain 25217958
nsv1075678 CNV deletion 25765185
nsv1128520 CNV deletion 24896259
nsv1150724 CNV deletion 26484159
nsv956099 CNV deletion 24416366

Variation tolerance for ODF2 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ODF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ODF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF2 Gene

Disorders for ODF2 Gene

Relevant External Links for ODF2

Genetic Association Database (GAD)
ODF2
Human Genome Epidemiology (HuGE) Navigator
ODF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ODF2

No disorders were found for ODF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ODF2 Gene

Publications for ODF2 Gene

  1. The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. (PMID: 23400999) Kuhns S. … Pereira G. (J. Cell Biol. 2013) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. (PMID: 16966375) Soung N.-K. … Lee K.S. (Mol. Cell. Biol. 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa. (PMID: 10381817) Petersen C. … Hoyer-Fender S. (Mol. Hum. Reprod. 1999) 3 4 64

Products for ODF2 Gene

Sources for ODF2 Gene

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