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ODF2 Gene

protein-coding   GIFtS: 60
GCID: GC09P131218

Outer Dense Fiber Of Sperm Tails 2

(Previous name: outer dense fibre of sperm tails 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Outer Dense Fiber Of Sperm Tails 21 2     Cenexin 12
Cancer/Testis Antigen 1341 2     Outer Dense Fiber Of Sperm Tails, 84-KD2
ODF842 5     Outer Dense Fiber Protein 22
Outer Dense Fibre Of Sperm Tails 21     Sperm Tail Structural Protein2
CT1342     Cenexin3
ODF2/12     Outer Dense Fiber Of Sperm Tails Protein 23
ODF2/22     

External Ids:    HGNC: 81141   Entrez Gene: 49572   Ensembl: ENSG000001368117   OMIM: 6020155   UniProtKB: Q5BJF63   

Export aliases for ODF2 gene to outside databases

Previous GC identifers: GC09P122333 GC09P122864 GC09P124672 GC09P126595 GC09P126596 GC09P128297 GC09P130258 GC09P100831


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ODF2 Gene:
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal
piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as
well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the
outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer
dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also
known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic
centrioles and thought to be crucial for the formation of microtubule organizing centers. (provided by RefSeq,
Oct 2010)

GeneCards Summary for ODF2 Gene:
ODF2 (outer dense fiber of sperm tails 2) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is ODF2L.

UniProtKB/Swiss-Prot: ODFP2_HUMAN, Q5BJF6
Function: Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures
located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may
help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating
influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the
distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the
localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1
assembly

Gene Wiki entry for ODF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ODF2 gene promoter:
         HOXA9B   HOXA9   Nkx2-5   Tal-1beta   Meis-1b   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidODF2 promoter sequence
   Search Chromatin IP Primers for ODF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ODF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34

ODF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ODF2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131218:  view genomic region     (about GC identifiers)

Start:
131,217,434 bp from pter      End:
131,263,571 bp from pter
Size:
46,138 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ODFP2_HUMAN, Q5BJF6 (See protein sequence)
Recommended Name: Outer dense fiber protein 2  
Size: 829 amino acids; 95401 Da
Subunit: Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the
microtubule network. Interacts via its C-terminus with PLK1. Interacts with ODF1 (By similarity)
Sequence caution: Sequence=AAC08409.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B1AND3 B4DRK4 B4DX73 B4DZ02 E7EWL2 F5H6J4 O14721 O60631 Q1W2J6 Q6UN26
Q7Z5I6 Q96FN2
Alternative splicing: 10 isoforms:  Q5BJF6-1   Q5BJF6-2   Q5BJF6-3   Q5BJF6-4   Q5BJF6-5   Q5BJF6-6   Q5BJF6-7   Q5BJF6-8   
Q5BJF6-9   Q5BJF6-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ODF2: NX_Q5BJF6

Explore proteomics data for ODF2 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated (By similarity)1
  • Ubiquitination2 at Lys204, Lys210, Lys223, Lys253, Lys259, Lys295
  • Modification sites at PhosphoSitePlus

  • See ODF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (11 alternative transcripts): 
    NP_001229281.1  NP_001229282.1  NP_001229283.1  NP_002531.3  NP_702910.1  NP_702911.1  NP_702913.1  NP_702914.1  
    NP_702915.1  NP_702917.1  NP_702918.1  

    ENSEMBL proteins: 
     ENSP00000474949   ENSP00000377166   ENSP00000361901   ENSP00000473949   ENSP00000396687  
     ENSP00000377161   ENSP00000403453   ENSP00000437579   ENSP00000415290   ENSP00000395489  
     ENSP00000407852   ENSP00000361877   ENSP00000475118   ENSP00000394506   ENSP00000361893  
     ENSP00000474651   ENSP00000342581   ENSP00000443178  
    Reactome Protein details: Q5BJF6

    ODF2 Human Recombinant Protein Products:

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    Novus Biologicals ODF2 Protein
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    Cloud-Clone Corp. Proteins for ODF2

     
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    LSBio Antibodies in human, mouse, rat for ODF2

    ODF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ODF2
    Cloud-Clone Corp. CLIAs for ODF2
    Search eBioscience for ELISAs for ODF2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026099 Odf2-rel

    Graphical View of Domain Structure for InterPro Entry Q5BJF6

    ProtoNet protein and cluster: Q5BJF6

    UniProtKB/Swiss-Prot: ODFP2_HUMAN, Q5BJF6
    Similarity: Belongs to the ODF2 family


    Find genes that share domains with ODF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ODFP2_HUMAN, Q5BJF6
    Function: Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures
    located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may
    help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating
    influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the
    distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the
    localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1
    assembly

         Genatlas biochemistry entry for ODF2:
    outer dense fiber protein 2,component of the filamentous structure of the sperm tail,expressed in round spermatids
    extending to about half the principal piece of tail sperm,involved in sperm tail function and motility

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity TAS10072582
    GO:0005515protein binding IPI16980960
         
    Find genes that share ontologies with ODF2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for ODF2:
     Actin fiber cells  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Increased cell death HMECs cel 

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Odf2):
     cellular  digestive/alimentary  embryogenesis  growth/size/body  hearing/vestibular/ear 
     immune system  mortality/aging  nervous system  reproductive system  respiratory system 

    Find genes that share phenotypes with ODF2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ODF2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ODF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ODF2

    miRNA
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    miRTarBase miRNAs that target ODF2:
    hsa-mir-26b-5p (MIRT030045), hsa-mir-375 (MIRT020042)

    Block miRNA regulation of human, mouse, rat ODF2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ODF2:
    hsa-miR-1271 hsa-miR-483-3p hsa-miR-135b hsa-miR-182 hsa-miR-370 hsa-miR-3682-3p hsa-miR-96 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidODF2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ODF2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 7): ODF2 (NM_153435)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ODF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODF2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ODF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ODFP2_HUMAN, Q5BJF6: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium.
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle
    pole. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized
    at the distal/subdistal appendages of mother centrioles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0001520outer dense fiber IEA--
    GO:0005813centrosome IDA--
    GO:0005814centriole IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ODF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ODF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90


    Find genes that share SuperPaths with ODF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for ODF2
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    Loss of Nlp from mitotic centrosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ODF2
    Interactions:

        GeneGlobe Interaction Network for ODF2

    3 Interacting proteins for ODF2 (Q5BJF62, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543I2D: score=2 
    ODF1Q149903I2D: score=1 
    --O463852MINT-7902838 MINT-7902821
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis ----
    GO:0007286spermatid development IEA--

    Find genes that share ontologies with ODF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ODF2 (ODFP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ODF2 gene (11 alternative transcripts): 
    NM_001242352.1  NM_001242353.1  NM_001242354.1  NM_002540.4  NM_153432.1  NM_153433.1  NM_153435.1  NM_153436.1  
    NM_153437.2  NM_153439.1  NM_153440.1  

    Unigene Cluster for ODF2:

    Outer dense fiber of sperm tails 2
    Hs.129055  [show with all ESTs]
    Unigene Representative Sequence: NM_002540
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000497812 ENST00000393533(uc011maz.2) ENST00000372814(uc022boj.1 uc004bva.3)
    ENST00000469582 ENST00000444993 ENST00000604420 ENST00000448249(uc011mbc.2)
    ENST00000393527(uc004bvh.3) ENST00000434106 ENST00000546203(uc010myc.3 uc011mbf.2)
    ENST00000446274 ENST00000421776 ENST00000432065 ENST00000372791(uc004bve.3)
    ENST00000470061 ENST00000444119 ENST00000372807(uc011mba.2 uc010myb.3)
    ENST00000483070
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ODF2:
    hsa-miR-1271 hsa-miR-483-3p hsa-miR-135b hsa-miR-182 hsa-miR-370 hsa-miR-3682-3p hsa-miR-96 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidODF2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 7): ODF2 (NM_153435)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODF2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ODF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ODF2
      QuantiTect SYBR Green Assays in human, mouse, rat ODF2
      QuantiFast Probe-based Assays in human, mouse, rat ODF2

    Additional mRNA sequence: 

    AF012549.1 AF053970.1 AK093367.1 AK299303.1 AK300793.1 AK301754.1 AK301842.1 AK301855.1 
    AK302684.1 AK308278.1 AK309917.1 AY319414.1 AY366499.1 BC010629.1 BC012785.2 BC091500.1 
    DQ444713.1 DQ444714.1 

    Selected DOTS entries (see all 31):

    DT.100027904  DT.441028  DT.101984564  DT.121155149  DT.40206733  DT.100812960  DT.101984565  DT.95155916 
    DT.91757262  DT.97847388  DT.95155907  DT.121155171  DT.91757256  DT.91757259  DT.40251440  DT.100812956 
    DT.40213676  DT.91757257  DT.91757267  DT.95155914  DT.95155926  DT.100768846  DT.40119153  DT.95155917 

    Selected AceView cDNA sequences (see all 265):

    CB123358 CD244287 BI826203 AI750706 BP374653 BI829334 BE793816 NM_002540 
    BQ436203 AW438804 AL040952 AW614067 BX375038 BM835331 BE869324 BM853853 
    BM824222 BQ226625 BU727859 AY366499 AI634153 AU131912 BC012785 AL040953 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ODF2 (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e ·
    SP1:                                -     -     -     -     -     -     -     -     -                       -                 -                                 
    SP2:                                -     -     -     -     -     -     -     -     -     -           -     -                 -                                 
    SP3:                                                              -     -     -     -                 -     -     -                                             
    SP4:                                                                                -                 -     -     -           -                                 
    SP5:                                -     -     -     -     -     -     -     -     -     -           -     -     -                                             

    ExUns: 9f ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c · 23d ^ 24a · 24b · 24c ·
    SP1:                                -                                   -                             -           -     -     -           -     -               
    SP2:                                -                                   -                             -           -     -     -           -     -               
    SP3:                                -                                   -                             -           -     -     -           -     -               
    SP4:                                -                                   -                             -                                                         
    SP5:                                -                                   -                             -                                                         

    ExUns: 24d ^ 25 ^ 26a · 26b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ODF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ODF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTTGCTCC
    ODF2 Expression
    About this image


    ODF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    ODF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ODF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129055

    UniProtKB/Swiss-Prot: ODFP2_HUMAN, Q5BJF6
    Tissue specificity: Testis-specific (at protein level). Highly expressed in cytoplasm of step 2 round spermatids.
    Detected in the middle piece and extends to about half the principal piece of the sperm tails

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ODF2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Odf21 , 5 outer dense fiber of sperm tails 21, 5 90.6(n)1
    97.39(a)1
      2 (20.79 cM)5
    182861  NM_001177659.11  NP_001171130.11 
     298892215 
    chicken
    (Gallus gallus)
    Aves ODF21 outer dense fiber of sperm tails 2 71.29(n)
    71.62(a)
      417213  NM_001012799.1  NP_001012817.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    73(a)
    61(a)
    many → 1
    many → 1
    GL344038.1(87534-93917)
    GL344038.1(98410-102567)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.134862 Xenopus laevis transcribed sequence with weak similarity more 72.09(n)    BQ731573.1 
    zebrafish
    (Danio rerio)
    Actinopterygii odf2a1 outer dense fiber of sperm tails 2a 58(n)
    52.25(a)
      792921  XM_001332528.5  XP_001332564.5 


    ENSEMBL Gene Tree for ODF2 (if available)
    TreeFam Gene Tree for ODF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ODF2 gene
    ODF2L2  
    1 SIMAP similar gene for ODF2 using alignment to 12 protein entries:     ODFP2_HUMAN (see all proteins):
    ODF2L

    Find genes that share paralogs with ODF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ODF2 (see all 1063)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1490788061,2
    C--100830715(+) CAGGG-/GAGAGAG 1 -- int10--------
    rs283726681,2
    F--100830719(+) GGAGA-/GAGGCCG 11 -- us2k1 int1 trp32Minor allele frequency- GA:0.41MN EA 1252
    rs1126845911,2
    C--100831796(+) CCGGC-/GGGGGG 11 -- int1 us2k11Minor allele frequency- G:0.00CSA 2
    rs596114941,2
    C--100833178(+) TCGCT-/CCAGCC 11 -- int12Minor allele frequency- C:0.00NA CSA 4
    rs1435307331,2
    C--100850155(+) ATGAC-/TGTAGTT 11 -- int10--------
    rs611279681,2
    C--100850156(+) TGACT-/GTAGTTC 11 -- int10--------
    rs1511107541,2
    C--100862621(+) ACACAA/CACACA 11 -- int10--------
    rs96329151,2
    C,F,A,H--100862643(+) ACACAC/AACAAA 11 -- int19Minor allele frequency- A:0.39NS EA NA WA CSA 424
    rs562605921,2
    C--131217674(+) ATACA-/AAAAAA 11 -- us2k1 int10--------
    rs59007961,2
    C--131217958(+) GAGAG-/AG/GA 
            
    GCCGG
    11 -- us2k1 int1 trp30--------

    HapMap Linkage Disequilibrium report for ODF2 (131217434 - 131263571 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ODF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739072CNV Deletion23290073
    esv1639805CNV Deletion17803354
    esv2150257CNV Deletion18987734
    dgv8294n71CNV Loss21882294
    nsv893898CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ODF2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602015    OMIM disorders: --


    Find genes that share disorders with ODF2           About GenesLikeMe

    Genetic Association Database (GAD): ODF2
    Human Genome Epidemiology (HuGE) Navigator: ODF2 (1 document)

    Export disorders for ODF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ODF2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with ODF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. (PubMed id 16966375)1, 2 Soung N.-K....Lee K.S. (Mol. Cell. Biol. 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa. (PubMed id 10381817)1, 2 Petersen C.... Hoyer-Fender S. (Mol. Hum. Reprod. 1999)
    5. Human outer dense fiber gene, ODF2, localizes to chromosome 9q34. (PubMed id 10072582)1, 3 Shao X.... van der Hoorn F.A. (Cytogenet. Cell Genet. 1998)
    6. Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27. (PubMed id 9045620)1, 3 Shao X....van der Hoorn F.A. (J. Biol. Chem. 1997)
    7. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    8. Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (Oncogene 2012)
    9. Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation. (PubMed id 22833046)1 Tarapore P....Fukasawa K. (Cell Cycle 2012)
    10. A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation. (PubMed id 22911743)1 Steere N....Kuriyama R. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4957 HGNC: 8114 AceView: ODF2 Ensembl:ENSG00000136811 euGenes: HUgn4957
    ECgene: ODF2 H-InvDB: ODF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ODF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ODF2 gene:
    Search GeneIP for patents involving ODF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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