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Aliases for ODF1 Gene

Aliases for ODF1 Gene

  • Outer Dense Fiber Of Sperm Tails 1 2 3
  • Cancer/Testis Antigen 133 2 3
  • ODFP 3 4
  • Outer Dense Fiber Of Sperm Tails, 27-KD 3
  • Outer Dense Fibre Of Sperm Tails 1 2
  • Outer Dense Fiber Protein 1 3
  • HSPB10 3
  • ODFPGA 3
  • ODFPGB 3
  • CT133 3
  • ODF27 3
  • ODFPG 3
  • ODF2 3
  • SODF 3
  • ODF 3
  • RT7 3

External Ids for ODF1 Gene

Previous GeneCards Identifiers for ODF1 Gene

  • GC08P103632
  • GC08P103232
  • GC08P103520
  • GC08P103633
  • GC08P098764

Summaries for ODF1 Gene

Entrez Gene Summary for ODF1 Gene

  • The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ODF1 Gene

ODF1 (Outer Dense Fiber Of Sperm Tails 1) is a Protein Coding gene. Diseases associated with ODF1 include infertility. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include structural molecule activity and protein domain specific binding.

UniProtKB/Swiss-Prot for ODF1 Gene

  • Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail

Gene Wiki entry for ODF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF1 Gene

Genomics for ODF1 Gene

Regulatory Elements for ODF1 Gene

Genomic Location for ODF1 Gene

Start:
102,551,572 bp from pter
End:
102,561,017 bp from pter
Size:
9,446 bases
Orientation:
Plus strand

Genomic View for ODF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ODF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF1 Gene

Proteins for ODF1 Gene

  • Protein details for ODF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14990-ODFP1_HUMAN
    Recommended name:
    Outer dense fiber protein 1
    Protein Accession:
    Q14990
    Secondary Accessions:
    • Q3SX72

    Protein attributes for ODF1 Gene

    Size:
    250 amino acids
    Molecular mass:
    28366 Da
    Quaternary structure:
    • Interacts with SPAG4 and KLC3.

neXtProt entry for ODF1 Gene

Proteomics data for ODF1 Gene at MOPED

Post-translational modifications for ODF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ODF1 Gene

Domains for ODF1 Gene

Gene Families for ODF1 Gene

HGNC:
  • HSPB :Heat shock proteins / HSPB

Protein Domains for ODF1 Gene

Suggested Antigen Peptide Sequences for ODF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14990

UniProtKB/Swiss-Prot:

ODFP1_HUMAN :
  • Q14990
Domain:
  • The C-terminal contains many C-X-P repeats
genes like me logo Genes that share domains with ODF1: view

Function for ODF1 Gene

Molecular function for ODF1 Gene

GENATLAS Biochemistry: outer dense fiber protein 1,component of the filamentous structures of the sperm tail
UniProtKB/Swiss-Prot Function: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail

Gene Ontology (GO) - Molecular Function for ODF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with ODF1: view

Phenotypes for ODF1 Gene

MGI mutant phenotypes for ODF1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ODF1: view

Animal Models for ODF1 Gene

MGI Knock Outs for ODF1:

Animal Model Products

CRISPR Products

miRNA for ODF1 Gene

miRTarBase miRNAs that target ODF1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ODF1 Gene

Localization for ODF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ODF1 Gene COMPARTMENTS Subcellular localization image for ODF1 gene
Compartment Confidence
extracellular 3
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ODF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001520 outer dense fiber IEA --
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with ODF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ODF1 Gene

Pathways for ODF1 Gene

genes like me logo Genes that share pathways with ODF1: view

Pathways by source for ODF1 Gene

Gene Ontology (GO) - Biological Process for ODF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ODF1: view

Compounds for ODF1 Gene

(1) Novoseek inferred chemical compound relationships for ODF1 Gene

Compound -log(P) Hits PubMed IDs
leucine 42.3 3
genes like me logo Genes that share compounds with ODF1: view

Transcripts for ODF1 Gene

mRNA/cDNA for ODF1 Gene

(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ODF1 Gene

Outer dense fiber of sperm tails 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ODF1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ODF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF1 Gene

No ASD Table

Relevant External Links for ODF1 Gene

GeneLoc Exon Structure for
ODF1
ECgene alternative splicing isoforms for
ODF1

Expression for ODF1 Gene

mRNA expression in normal human tissues for ODF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ODF1 Gene

This gene is overexpressed in Testis (52.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ODF1 Gene

SOURCE GeneReport for Unigene cluster for ODF1 Gene Hs.159274

mRNA Expression by UniProt/SwissProt for ODF1 Gene

Q14990-ODFP1_HUMAN
Tissue specificity: Testis
genes like me logo Genes that share expressions with ODF1: view

In Situ Assay Products

Orthologs for ODF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ODF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODF1 35
  • 98.13 (n)
  • 97.6 (a)
ODF1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ODF1 35
  • 88.13 (n)
  • 95.6 (a)
ODF1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ODF1 35
  • 87.82 (n)
  • 96.39 (a)
ODF1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Odf1 35
  • 85.11 (n)
  • 96.17 (a)
Odf1 16
Odf1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ODF1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Odf1 35
  • 86.1 (n)
  • 96.17 (a)
chicken
(Gallus gallus)
Aves ODF1 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ODF1 36
  • 44 (a)
OneToOne
Species with no ortholog for ODF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ODF1 Gene

ENSEMBL:
Gene Tree for ODF1 (if available)
TreeFam:
Gene Tree for ODF1 (if available)

Paralogs for ODF1 Gene

No data available for Paralogs for ODF1 Gene

Variants for ODF1 Gene

Sequence variations from dbSNP and Humsavar for ODF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs892504 -- 102,550,075(+) CAGAA(A/C)GTCCT upstream-variant-2KB
rs892505 -- 102,550,311(+) TTAAG(A/G)TGAGT upstream-variant-2KB
rs892506 -- 102,550,368(+) AAGTC(A/G)CTGTG upstream-variant-2KB
rs892507 -- 102,550,953(+) CATCC(A/G)GAGGC upstream-variant-2KB
rs919952 -- 102,551,156(+) GCTGA(C/T)TTGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ODF1 Gene

Variant ID Type Subtype PubMed ID
esv33118 CNV Loss 17666407
esv2669040 CNV Deletion 23128226
esv22177 CNV Loss 19812545

Relevant External Links for ODF1 Gene

HapMap Linkage Disequilibrium report
ODF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF1 Gene

Disorders for ODF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ODF1 Gene including...

Search for ODF1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for ODF1 Gene

Disease -log(P) Hits PubMed IDs
infertility male 51.4 1

Relevant External Links for ODF1

Genetic Association Database (GAD)
ODF1
Human Genome Epidemiology (HuGE) Navigator
ODF1
genes like me logo Genes that share disorders with ODF1: view

No data available for UniProtKB/Swiss-Prot for ODF1 Gene

Publications for ODF1 Gene

  1. Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene. (PMID: 8305202) Gastmann O. … Hoyer-Fender S. (Mol. Reprod. Dev. 1993) 2 3 4 23
  2. Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme. (PMID: 10373309) Shao X. … van der Hoorn F.A. (Dev. Biol. 1999) 3 23
  3. Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa. (PMID: 10381817) Petersen C. … Hoyer-Fender S. (Mol. Hum. Reprod. 1999) 3 23
  4. Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells. (PMID: 11774369) Kierszenbaum A.L. (Mol. Reprod. Dev. 2002) 3 23
  5. A homozygous deletion of 27 basepairs in the coding region of the human outer dense fiber protein gene does not result in a pathologic phenotype. (PMID: 8111388) Hofferbert S. … Engel W. (Hum. Mol. Genet. 1993) 3 4

Products for ODF1 Gene

Sources for ODF1 Gene

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