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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ODC1 Gene

protein-coding GIFtS: 73
GCID: GC02M010580

ornithine decarboxylase 1

Explore 119 diseases affiliated with
ODC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ornithine Decarboxylase 1¹ ²
ODC¹ ² ³
EC 4.1.1.17³ ⁸
Ornithine Decarboxylase²

External Ids:	HGNC: 8109¹	Entrez Gene: 4953²	Ensembl: ENSG00000115758⁷	OMIM: 165640⁵	UniProtKB: P11926³

Export aliases for ODC1 gene to outside databases

Previous GC identifers: GC02M010365 GC02M010631 GC02M010602 GC02M010531 GC02M010497 GC02M010432

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ODC1:

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to

putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high

turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene

encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. (provided by

RefSeq, Jul 2008)

Gene Wiki entry for ODC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005334.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ODC1 gene promoter:
AML1a Lmo2 Nkx3-1 v1 Ik-3 RORalpha2 PPAR-gamma1 FOXO4 STAT3 PPAR-gamma2 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ODC1 promoter sequence

Search SABiosciences Chromatin IP Primers for ODC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ODC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25

ODC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ODC1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M010580: view genomic region (about GC identifiers)

Start:	10,580,094 bp from pter	End:	10,588,630 bp from pter
Size:	8,537 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926 (See protein sequence)

Recommended Name: Ornithine decarboxylase

Size: 461 amino acids; 51148 Da

Cofactor: Pyridoxal phosphate

Subunit: Homodimer

3 PDB 3D structures from and Proteopedia for ODC1:

1D7K (3D)

2ON3 (3D)

2OO0 (3D)

Secondary accessions: Q53TU3 Q6LDS9

Explore the universe of human proteins at neXtProt for ODC1: NX_P11926

Post-translational modifications:

S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11926

4/18 DME Specific Peptides for ODC1 (P11926) (see all 18)

ELMKVAR

IWGPTCD

LDIGGGF

SQIKYAA

ODC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002530.1

ENSEMBL proteins:

ENSP00000234111 ENSP00000385333 ENSP00000390691

Reactome Protein details: P11926
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals ODC1 Proteins Novus Biologicals ODC1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ODC1
	Uscn Proteins for ODC1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005829	cytosol	TAS	--

ODC1 for ontologies About GeneDecksing

ODC1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ODC1
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	OriGene Antibodies (see all 3): ODC1 OriGene Custom Antibody Services for ODC1
	GenScript Custom Superior Antibodies Services for ODC1
	Novus Biologicals ODC1 Antibodies
	Abcam antibodies for ODC1
	Uscn Antibodies for ODC1
	ThermoFisher Antibodies for ODC1

Assay Products for ODC1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ODC1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ODC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ODC1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR009006 Ala_racemase/Decarboxylase_C

IPR000183 Orn/DAP/Arg_de-COase

IPR022657 De-COase2_CS

IPR002433 Orn_de-COase

IPR022644 De-COase2_N

Graphical View of Domain Structure for InterPro Entry P11926

ProtoNet protein and cluster: P11926

2 Blocks protein families:

IPB000183 Orn/DAP/Arg decarboxylase

IPB002433 Ornithine decarboxylase signature

UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926

Catalytic activity: L-ornithine = putrescine + CO(2)

Enzyme regulation: Inhibited by S-nitrosylation

Induction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level)

Genatlas biochemistry entry for ODC1:

ornithine decarboxylase 1,ornithine metabolism,mitochondrial matrix

Enzyme Number (IUBMB): EC 4.1.1.17¹ ²

miRNA Products:		miRTarBase miRNAs that target ODC1: hsa-mir-192 (MIRT004127)

		OriGene 3'-UTR Clone: ODC1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ODC1
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate ODC1:
		hsa-miR-3163 hsa-miR-3671 hsa-miR-595 hsa-miR-187* hsa-miR-1283 hsa-miR-3914 hsa-miR-587 hsa-miR-548c-3p

		SwitchGear 3'UTR luciferase reporter plasmid: ODC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ODC1 (see all 7) OriGene shRNA RFP: ODC1 OriGene siRNA: ODC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ODC1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ODC1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ODC1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ODC1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ODC1 (NM_002539)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ODC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODC1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ODC1
		Search LifeMap BioReagents cell lines for ODC1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ODC1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004586	ornithine decarboxylase activity	TAS	2317811

ODC1 for ontologies About GeneDecksing

7 GenomeRNAi human phenotypes for ODC1:

Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased Salmonella enterica
Decreased Salmonella enterica	Decreased Salmonella-containin	Synthetic lethal with Ras

Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Odc1):

cellular

embryogenesis

mortality/aging

normal

ODC1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Arginine and proline metabolism

Arginine and proline metabolism

1.00

Urea cycle and metabolism of amino groups

0.36

Ubiquitinated Orc1 is degraded by the proteasome

26S proteosome degrades ODC holoenzyme complex

0.83

Regulation of ornithine decarboxylase (ODC)

0.80

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

Validated targets of C-MYC transcriptional activation

Validated targets of C-MYC transcriptional activation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for ODC1

	Urea cycle and metabolism of amino groups
	Validated targets of C-MYC transcriptional activation
	putrescine biosynthesis III

5 Reactome Pathways for ODC1

	26S proteosome degrades ODC holoenzyme complex
	Regulation of ornithine decarboxylase (ODC)
	Metabolism of polyamines
	Metabolism
	Metabolism of amino acids and derivatives

3 Kegg Pathways (Kegg details for ODC1):

	Arginine and proline metabolism
	Glutathione metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926

Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from

L-ornithine: step 1/1

ODC1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ODC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/94 Interacting proteins for ODC1 (P11926^{1, 2, 3} ENSP00000234111⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 94)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD3	P84022²^,³, ENSP00000332973⁴	MINT-51238 I2D: score=1 STRING: ENSP00000332973
CSNK2B	P67870²^,³	MINT-8253495 I2D: score=2
OAZ2	O95190¹^,³	EBI-1044287,EBI-1051861 I2D: score=2
TK1	P04183²^,³	MINT-8273840 I2D: score=2
AMD1	P17707³, ENSP00000357880⁴	I2D: score=2 STRING: ENSP00000357880

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001822	kidney development	IEA	--
GO:0006521	regulation of cellular amino acid metabolic process	TAS	--
GO:0006595	polyamine metabolic process	TAS	--
GO:0006596	polyamine biosynthetic process	NAS	--
GO:0008284	positive regulation of cell proliferation	IEA	--

ODC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ODC1 for compounds About GeneDecksing

EMD Millipore small molecules for ODC1:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for ODC1

Browse Tocris compounds for ODC1

9 HMDB Compounds for ODC1 About this table

Compound	Synonyms	CAS #	PubMed Ids
1,3-Diaminopropane	1,3-Diamino-n-propane (see all 8)	109-76-2	--
Carbon dioxide	Carbon oxide (see all 5)	124-38-9	--
N1-Acetylspermine	N'-Acetylspermine (see all 6)	25593-72-0	--
Norspermidine	N-(3-aminopropyl)-1,3-Propanediamine (see all 28)	56-18-8	--
Ornithine	(+)-S-Ornithine (see all 9)	70-26-8	--
Putrescine	1,4-Butanediamine (see all 8)	110-60-1	--
Pyridoxal 5'-phosphate	Apolon B6 (see all 27)	54-47-7	--
Spermidine	1,5,10-Triazadecane (see all 15)	124-20-9	--
Spermine	1,5,10,14-Tetraazatetradecane (see all 18)	71-44-3	--

8 DrugBank Compounds for ODC1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Spermine	1, 4-Bis(aminopropyl)butanediamine (see all 5)	71-44-3	target	product of	11160858 10712236 10698696 11413269 21140446 11408092
Pyridoxal Phosphate	Codecarboxylase (see all 9)	54-47-7	target	cofactor	12460114 11683631 12627959 12672797 15476392
Alpha-Difluoromethylornithine	--	--	target	--	17139284 17016423 10592235
G418	--	49863-47-0	target	--	17139284 17016423 10592235
N-Pyridoxyl-Glycine-5-Monophosphate	--	--	target	--	17139284 17016423 10592235
Putrescine	--	110-60-1	target	--	17139284 17016423 10592235
Pyridoxine-5'-Phosphate	--	447-05-2	target	--	17139284 17016423 10592235
N'-Pyridoxyl-Lysine-5'-Monophosphate	--	--	target	--	17139284 17016423

10/158 Novoseek chemical compound relationships for ODC1 gene (see all 158) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ornithine	98.9	2890	11461922 (8), 8719885 (8), 1872891 (7), 8354283 (7) (see all 99)
dfmo	96.3	540	7646459 (5), 8221660 (5), 1932110 (4), 19047162 (4) (see all 99)
putrescine	94.7	273	1952937 (6), 8719885 (6), 2146783 (5), 1545142 (5) (see all 99)
spermidine	94.1	239	1872863 (4), 2241982 (4), 8486633 (4), 11123206 (3) (see all 99)
spermine	92.5	185	2127337 (5), 2344358 (5), 11123206 (4), 1573975 (3) (see all 99)
s-adenosylmethionine	83	130	7954423 (3), 2314049 (2), 1930914 (2), 1499693 (2) (see all 84)
1-aminooxy-3-aminopropane	80.1	9	17407445 (2), 8462122 (1), 11163334 (1), 7896733 (1)
denspm	78.7	10	8371417 (1), 10951496 (1), 7954423 (1), 19097065 (1) (see all 5)
sam 486a	77.5	4	15547724 (1), 15704548 (1), 8877009 (1)
n1-acetylspermidine	75.5	1	12355213 (1)

Search CenterWatch for drugs/clinical trials and news about ODC1 / DCOR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ODC1 gene:

NM_002539.1

Unigene Cluster for ODC1:

Ornithine decarboxylase 1

Hs.467701 [show with all ESTs]

Unigene Representative Sequence: NM_002539

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000234111(uc002rao.1 uc010yjd.1) ENST00000405333(uc010exg.1)

ENST00000446285 ENST00000443218(uc010exh.1)

miRNA Products:		OriGene 3'-UTR Clone: ODC1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ODC1
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate ODC1:
		hsa-miR-3163 hsa-miR-3671 hsa-miR-595 hsa-miR-187* hsa-miR-1283 hsa-miR-3914 hsa-miR-587 hsa-miR-548c-3p

		SwitchGear 3'UTR luciferase reporter plasmid: ODC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ODC1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ODC1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ODC1 (NM_002539)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ODC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODC1

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ODC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ODC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ODC1

Additional cDNA sequence:

AK292352.1 AK301956.1 AK312766.1 BC014562.2 BC025296.1 D28365.1 DQ185043.1 M16650.2

M20372.1 X55362.1

24/37 DOTS entries (see all 37):

DT.40254377 DT.100669014 DT.95110200 DT.100880136 DT.120936261 DT.120936299 DT.100762913 DT.40125078

DT.92462214 DT.92462225 DT.85104235 DT.100659486 DT.92462212 DT.95197533 DT.100039111 DT.100880128

DT.95197532 DT.100705807 DT.100771956 DT.100880124 DT.100880142 DT.120936269 DT.120936276 DT.120936288

24/834 AceView cDNA sequences (see all 834):

BQ421820 BQ064242 BU727301 BU556791 BQ018216 CF131875 BQ423032 BU854730

BQ721981 BG394254 AW675526 BU688315 BU181893 BM799921 BG686916 CB216477

BE779234 BI826443 AL514594 AI061312 BQ059186 BM667082 BQ014883 BE728546

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ODC1 (see all 14) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·
SP1:													-		-		-		-																														-		-
SP2:					-		-		-		-		-		-		-		-
SP3:									-		-		-		-		-		-
SP4:																	-		-
SP5:													-		-		-		-		-		-

ExUns:	15b	^	16	^	17a	·	17b	^	18
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ODC1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ODC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCAGCCAT

About this image
See ODC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ODC1

SOURCE GeneReport for Unigene cluster: Hs.467701

SABiosciences Expression via Pathway-Focused PCR Arrays including ODC1:

Nephrotoxicity in human mouse rat

Amino Acid Metabolism I in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

Osmotic Stress in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ODC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ODC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ODC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ODC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ODC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ODC1 gene from 10/38 species (see all 38) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ODC1¹	ornithine decarboxylase 1	78.19(n) 84.78(a)		421937 NM_001167766.1 NP_001161238.1
lizard (Anolis carolinensis)	Reptilia	ODC1⁶	--	87(a)	1 ↔ 1	1(147553131-147560117)
African clawed frog (Xenopus laevis)	Amphibia	odc1-prov²	ornithine decarboxylase 1	77.7(n)		BC044004.1
zebrafish (Danio rerio)	Actinopterygii	odc1²	ornithine decarboxylase 1	73.27(n)		114426 BC047796.1
fruit fly (Drosophila melanogaster)	Insecta	Odc1^{1 , 3}	polyamine biosynthesis ornithine decarboxylase less³ Ornithine decarboxylase 1¹	46(a) (best of 2)³ 51.63(n)¹ 48.74(a)¹		44A2³ 35766¹ NM_057704.4¹ NP_477052.2¹
worm (Caenorhabditis elegans)	Secernentea	odc-1^{1 , 3}	ornithine decarboxylase³ Protein ODC-1¹	46(a) (best of 2)³ 53.99(n)¹ 48.18(a)¹		V(6901184-6902556)³ 179079¹ NM_072351.5¹ NP_504752.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SPE1(YKL184W)⁴ SPE1¹	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation less⁴ Spe1p¹	52.38(n)¹ 50(a)¹		11(96757-98157)⁴ 853651^{1, 4} NP_012737.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G11880⁶ AT3G14390⁶	diaminopimelate decarboxylase 1	17(a) 17(a)	possible ortholog possible ortholog	5(3827526-3829986) 3(4806725-4809433)
rice (Oryza sativa)	Liliopsida	Os09g0543400¹	hypothetical protein	49.54(n) 46.39(a)		4347746 NM_001070362.2 NP_001063827.2
E. coli (Escherichia coli)	Gamma proteobacteria	lysA⁶	diaminopimelate decarboxylase, PLP-binding	15(a)	possible ortholog	Chromosome(2975659-2976921)

ENSEMBL Gene Tree for ODC1 (if available)
TreeFam Gene Tree for ODC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ODC1 gene

ADC² AZIN1²

2 SIMAP similar genes for ODC1 using alignment to 3 protein entries: DCOR_HUMAN (see all proteins):

ADC AZIN1

ODC1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for ODC1
PGOHUM00000235499 PGOHUM00000233565

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28362421^1,2	C,	--	10432273(-)	`TGTGTG/TTTCTT`	1	--	ds500¹		5	NS	190
rs28362420^1,2	C,	--	10432403(-)	`TGCCTG/ATGAGA`	1	--	ds500¹ ese³		6	NS NA	310
rs28362419^1,2	C,	--	10432596(-)	`TGTGGA/GCGGTG`	1	--	ds500¹ ese³		5	NS	190
rs16856239^1,2	C,F,	--	10432691(+)	`CTATAC/TGGGAT`	1	--	ds500¹ ese³		9	NA NS WA	446
rs28362418^1,2	C,F,H,	--	10432759(-)	`ATAAAG/ATATCT`	1	--	ut3¹ ese³		11	NS NA WA	1098
rs28362416^1,2	C,F,	--	10433501(-)	`AGACCC/TTGTCT`	1	--	int¹		7	NS NA	300
rs28362415^1,2	C,	--	10433600(-)	`GGCCAG/TGTGTG`	1	--	int¹		5	NS	178
rs28362413^1,2	C,F,	--	10433774(-)	`CTTGCC/GTAAGA`	1	--	int¹		7	NS WA	306
rs111482605^1,2	C	--	10434185(+)	`GCAGAA/C/TGGGGC`	3	H R L	mis¹		1	CSA	1
rs7599144^1,2	C,F,	--	10434641(+)	`ATCAAC/TAGACA`	1	--	int¹		8	NS NA CSA WA	312

HapMap Linkage Disequilibrium report for ODC1 (10580094 - 10588630 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ODC1
1 CNV: 72633
Human Gene Mutation Database (HGMD): ODC1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ODC1

DNA2.0 Custom Variant and Variant Library Synthesis for ODC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ODC1 for disorders           About GeneDecksing

OMIM gene information: 165640
OMIM disorders: 114500
20/119 diseases for ODC1 (see all 119):    About MalaCards

colonic adenoma recurrence, reduced risk of dermoid cyst peutz-jeghers syndrome familial adenomatous polyposis

cervical intraepithelial neoplasia wallerian degeneration transient cerebral ischemia xeroderma pigmentosum

dna topoisomerase ii barrett's esophagus cerebral artery occlusion autoimmune hemolytic anemia

iron overload hemolytic anemia anaplastic astrocytoma atrophic gastritis

sleeping sickness colonic polyps gastritis placental choriocarcinoma

3 diseases from the University of Copenhagen DISEASES database for ODC1:

Sleeping sickness Papilloma Colorectal cancer

10/93 Novoseek disease relationships for ODC1 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon cancer	54.6	39	11163334 (3), 7705952 (2), 18062235 (2), 15818733 (2) (see all 20)
colon adenocarcinoma	53.1	18	2317797 (2), 19470241 (2), 10816435 (1), 2113770 (1) (see all 8)
tumors	52.8	335	1951878 (6), 2317797 (6), 9293942 (5), 17582600 (5) (see all 99)
trypanosomiasis african	52.2	12	7598507 (1), 8347171 (1), 17504214 (1), 20220141 (1) (see all 7)
ehrlich ascites tumor	52	12	1847813 (3), 7647340 (1), 2384152 (1), 2115438 (1) (see all 6)
colon tumor	51.4	16	15918191 (5), 2009526 (3), 10395625 (1), 1598217 (1) (see all 7)
cancer	50.4	127	18339422 (3), 1423312 (3), 8348060 (3), 17957960 (3) (see all 62)
colon carcinoma	48.7	11	1997467 (1), 1324153 (1), 8444085 (1), 9293942 (1) (see all 8)
skin tumor	46.9	6	12201673 (1), 8640756 (1), 10874208 (1), 12757023 (1) (see all 5)
premalignant	45.1	9	9232343 (1), 11564951 (1), 16003136 (1), 8428179 (1) (see all 7)

Genetic Association Database (GAD): ODC1
Human Genome Epidemiology (HuGE) Navigator: ODC1 (14 documents)

Export disorders for ODC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ODC1 gene, integrated from 9 sources (see all 1044):
(articles sorted by number of sources associating them with ODC1)

Utopia: connect your pdf to the dynamic
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Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. (PubMed id 10623504)^{1, 2, 9} Almrud J.J....Hackert M.L. (2000)
Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells. (PubMed id 2317811)^{1, 2, 9} Hsieh J.T.... Verma A.K. (1990)
Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. (PubMed id 11461922)^{1, 2, 9} Bauer P.M.... Ignarro L.J. (2001)
Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. (PubMed id 12810952)^{1, 4, 9} Martinez M.E....Gerner E.W. (2003)
Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element. (PubMed id 8519686)^{1, 2, 9} Wright P.S.... Flanagan M.A. (1995)
Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells. (PubMed id 1598217)^{1, 2, 9} Moshier J.A.... Flanagan M.A. (1992)
Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)^{1, 2} Leong W.F. and Chow V.T. (2006)
Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population. (PubMed id 15734972)^{1, 4} You W.C....Gail M.H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene. (PubMed id 2227439)^{1, 2} Hickok N.J.... Jaenne O.A. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4953	HGNC: 8109	AceView: ODC1	Ensembl:ENSG00000115758	euGenes: HUgn4953
ECgene: ODC1	Kegg: 4953	H-InvDB: ODC1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ODC1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ODC1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/odc1/
Wikipedia	http://en.wikipedia.org/wiki/Ornithine_decarboxylase

Intellectual Property for ODC1 gene
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Patent Information for ODC1 gene:
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GeneCards and IP:
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ornithine decarboxylase 1

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ODC1 Gene

ornithine decarboxylase 1

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