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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ODC1 Gene

protein-coding   GIFtS: 73
GCID: GC02M010580

Ornithine Decarboxylase 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ornithine Decarboxylase 11 2
ODC2 3
EC 4.1.1.173 8
Ornithine Decarboxylase2

External Ids:    HGNC: 81091   Entrez Gene: 49532   Ensembl: ENSG000001157587   OMIM: 1656405   UniProtKB: P119263   

Export aliases for ODC1 gene to outside databases

Previous GC identifers: GC02M010365 GC02M010631 GC02M010602 GC02M010531 GC02M010497 GC02M010432


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ODC1 Gene:
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to
putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high
turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the
gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ODC1 Gene: 
ODC1 (ornithine decarboxylase 1) is a protein-coding gene. Diseases associated with ODC1 include colonic adenoma recurrence, reduced risk of, and cerebral artery occlusion, and among its related super-pathways are Metabolic pathways and Urea cycle and metabolism of amino groups. GO annotations related to this gene include ornithine decarboxylase activity. An important paralog of this gene is ADC.

Gene Wiki entry for ODC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005334.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ODC1 gene promoter:
         AML1a   Lmo2   Nkx3-1 v1   Ik-3   RORalpha2   PPAR-gamma1   FOXO4   STAT3   PPAR-gamma2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ODC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ODC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ODC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

ODC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ODC1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M010580:  view genomic region     (about GC identifiers)

Start:
10,580,094 bp from pter      End:
10,588,630 bp from pter
Size:
8,537 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926 (See protein sequence)
Recommended Name: Ornithine decarboxylase  
Size: 461 amino acids; 51148 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
3 PDB 3D structures from and Proteopedia for ODC1:
1D7K (3D)        2ON3 (3D)        2OO0 (3D)    
Secondary accessions: Q53TU3 Q6LDS9

Explore the universe of human proteins at neXtProt for ODC1: NX_P11926

Explore proteomics data for ODC1 at MOPED 

Post-translational modifications:

  • UniProtKB: S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11926

  • 4/18 DME Specific Peptides for ODC1 (P11926) (see all 18)
     ELMKVAR  IWGPTCD  LDIGGGF  SQIKYAA 

    ODC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ODC1 Protein Expression
    REFSEQ proteins: NP_002530.1  
    ENSEMBL proteins: 
     ENSP00000234111   ENSP00000385333   ENSP00000390691  
    Reactome Protein details: P11926
    Human Recombinant Protein Products for ODC1: 
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ODC1
    OriGene Protein Over-expression Lysate for ODC1
    OriGene MassSpec for ODC1 
    OriGene Custom Protein Services for ODC1
    GenScript Custom Purified and Recombinant Proteins Services for ODC1
    Novus Biologicals ODC1 Proteins
    Novus Biologicals ODC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ODC1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    ODC1 for ontologies           About GeneDecksing



    ODC1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for ODC1 

    Assay Products for ODC1: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Ornithine decarboxylase 
    Decarboxylases

    5/7 InterPro protein domains (see all 7):
     IPR009006 Ala_racemase/Decarboxylase_C
     IPR000183 Orn/DAP/Arg_de-COase
     IPR022657 De-COase2_CS
     IPR002433 Orn_de-COase
     IPR022644 De-COase2_N

    Graphical View of Domain Structure for InterPro Entry P11926

    ProtoNet protein and cluster: P11926

    2 Blocks protein domains:
    IPB000183 Orn/DAP/Arg decarboxylase
    IPB002433 Ornithine decarboxylase signature


    UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926
    Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family


    ODC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCOR_HUMAN, P11926
    Catalytic activity: L-ornithine = putrescine + CO(2)
    Enzyme regulation: Inhibited by S-nitrosylation
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level)

         Genatlas biochemistry entry for ODC1:
    ornithine decarboxylase 1,ornithine metabolism,mitochondrial matrix

         Enzyme Number (IUBMB): EC 4.1.1.171 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004586ornithine decarboxylase activity TAS2317811
         
    ODC1 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for ODC1:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Odc1):
     cellular  embryogenesis  mortality/aging  normal 

    ODC1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ODC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ODC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ODC1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ODC1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ODC1:
    hsa-mir-192 (MIRT004127)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ODC1
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate ODC1:
    hsa-miR-3163 hsa-miR-3671 hsa-miR-595 hsa-miR-187* hsa-miR-1283 hsa-miR-3914 hsa-miR-587 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidODC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ODC1
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ODC1 (see all 7)
    OriGene ORF clones in mouse, rat for ODC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ODC1 (NM_002539)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODC1
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    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ODC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ODC1 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2Arginine and proline metabolism
    Arginine and proline metabolism0.35
    Urea cycle and metabolism of amino groups0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    Regulation of ornithine decarboxylase (ODC)0.80
    4Glutathione metabolism
    Glutathione metabolism0.67
    5Methionine salvage pathway
    Metabolism of polyamines0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ODC1
        Validated targets of C-MYC transcriptional activation
    Urea cycle and metabolism of amino groups
    putrescine biosynthesis III

    4        Reactome Pathways for ODC1
        Regulation of ornithine decarboxylase (ODC)
    Metabolism of polyamines
    Metabolism
    Metabolism of amino acids and derivatives


    3         Kegg Pathways  (Kegg details for ODC1):
        Arginine and proline metabolism
    Glutathione metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926
    Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from
    L-ornithine: step 1/1


    ODC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ODC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/100 Interacting proteins for ODC1 (P119261, 2, 3 ENSP000002341114) via UniProtKB, MINT, STRING, and/or I2D (see all 100)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253495 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253495 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253495 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253495 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253495 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development IEA--
    GO:0006521regulation of cellular amino acid metabolic process TAS--
    GO:0006595polyamine metabolic process TAS--
    GO:0006596polyamine biosynthetic process NAS--
    GO:0008284positive regulation of cell proliferation IEA--

    ODC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ODC1 for compounds           About GeneDecksing

    EMD Millipore small molecules for ODC1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for ODC1

    Browse Tocris compounds for ODC1 (DCOR)

    9 HMDB Compounds for ODC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    1,3-Diaminopropane1,3-Diamino-n-propane (see all 8)109-76-2--
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Ornithine(+)-S-Ornithine (see all 9)70-26-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    8 DrugBank Compounds for ODC1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Spermine1, 4-Bis(aminopropyl)butanediamine (see all 5)71-44-3targetproduct of11160858 10712236 10698696 11413269 21140446 11408092
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor12460114 11683631 12627959 12672797 15476392
    Alpha-Difluoromethylornithine-- --target--17139284 17016423 10592235
    G418-- 49863-47-0target--17139284 17016423 10592235
    N-Pyridoxyl-Glycine-5-Monophosphate-- --target--17139284 17016423 10592235
    Putrescine-- 110-60-1target--17139284 17016423 10592235
    Pyridoxine-5'-Phosphate-- 447-05-2target--17139284 17016423 10592235
    N'-Pyridoxyl-Lysine-5'-Monophosphate-- --target--17139284 17016423

    6 IUPHAR Ligands for ODC1 (Ornithine decarboxylase)    About this table 
    LigandTypeActionAffinityPubmed IDs
    DFMO
    InhibitorInhibition--
    3-hydroxybenzylhydrazine
    InhibitorInhibition--
    L-α-methyldopa
    InhibitorInhibition--
    carbidopa
    InhibitorInhibition--
    APA
    InhibitorInhibition--
    benserazide
    InhibitorInhibition--

    10/158 Novoseek inferred chemical compound relationships for ODC1 gene (see all 158)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ornithine 98.9 2890 11461922 (8), 8719885 (8), 1872891 (7), 8354283 (7) (see all 99)
    dfmo 96.3 540 7646459 (5), 8221660 (5), 1932110 (4), 19047162 (4) (see all 99)
    putrescine 94.7 273 1952937 (6), 8719885 (6), 2146783 (5), 1545142 (5) (see all 99)
    spermidine 94.1 239 1872863 (4), 2241982 (4), 8486633 (4), 11123206 (3) (see all 99)
    spermine 92.5 185 2127337 (5), 2344358 (5), 11123206 (4), 1573975 (3) (see all 99)
    s-adenosylmethionine 83 130 7954423 (3), 2314049 (2), 1930914 (2), 1499693 (2) (see all 84)
    1-aminooxy-3-aminopropane 80.1 9 17407445 (2), 8462122 (1), 11163334 (1), 7896733 (1)
    denspm 78.7 10 8371417 (1), 10951496 (1), 7954423 (1), 19097065 (1) (see all 5)
    sam 486a 77.5 4 15547724 (1), 15704548 (1), 8877009 (1)
    n1-acetylspermidine 75.5 1 12355213 (1)

    Search CenterWatch for drugs/clinical trials and news about ODC1 / DCOR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ODC1 gene: 
    NM_002539.1  

    Unigene Cluster for ODC1:

    Ornithine decarboxylase 1
    Hs.467701  [show with all ESTs]
    Unigene Representative Sequence: NM_002539
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234111(uc002rao.1 uc010yjd.1) ENST00000405333(uc010exg.1)
    ENST00000446285 ENST00000443218(uc010exh.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate ODC1:
    hsa-miR-3163 hsa-miR-3671 hsa-miR-595 hsa-miR-187* hsa-miR-1283 hsa-miR-3914 hsa-miR-587 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidODC1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene clones in human, mouse for ODC1 (see all 7)
    OriGene ORF clones in mouse, rat for ODC1
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    GenScript: all cDNA clones in your preferred vector: ODC1 (NM_002539)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ODC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODC1
    Sirion Biotech Customized lentivirus for stable overexpression of ODC1 
                         Customized lentivirus expression plasmids for stable overexpression of ODC1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ODC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ODC1

    Additional mRNA sequence: 

    AK292352.1 AK301956.1 AK312766.1 BC014562.2 BC025296.1 D28365.1 DQ185043.1 M16650.2 
    M20372.1 X55362.1 

    24/37 DOTS entries (see all 37):

    DT.40254377  DT.100669014  DT.95110200  DT.100880136  DT.120936261  DT.120936299  DT.100762913  DT.40125078 
    DT.92462214  DT.92462225  DT.85104235  DT.100659486  DT.92462212  DT.95197533  DT.100039111  DT.100880128 
    DT.95197532  DT.100705807  DT.100771956  DT.100880124  DT.100880142  DT.120936269  DT.120936276  DT.120936288 

    24/834 AceView cDNA sequences (see all 834):

    BM450303 BC025296 BQ881663 AW575382 BU147064 BG471680 BQ424534 BP336774 
    BE728546 BQ648337 D16972 AI718948 BQ053902 AW410398 BM766295 CF131875 
    CD370646 BG428922 BM550249 BP334819 BU628106 BM667082 CA307827 BG403325 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ODC1 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
    SP1:                                      -     -     -     -                                                                                         -     -   
    SP2:              -     -     -     -     -     -     -     -                                                                                                   
    SP3:                          -     -     -     -     -     -                                                                                                   
    SP4:                                                  -     -                                                                                                   
    SP5:                                      -     -     -     -     -     -                                                                                       

    ExUns: 15b ^ 16 ^ 17a · 17b ^ 18
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for ODC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ODC1 expression in normal human tissues (normalized intensities)      ODC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCAGCCAT
    ODC1 Expression
    About this image


    ODC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             Ureter
             visceral organ/bladder   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Membranous Facial Bones
             sensory organ/ear/inner ear   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon

    See ODC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ODC1

    SOURCE GeneReport for Unigene cluster: Hs.467701
        SABiosciences Expression via Pathway-Focused PCR Arrays including ODC1: 
              Nephrotoxicity in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Osmotic Stress in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ODC1 gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Odc11 , 5 ornithine decarboxylase, structural 11, 5 86.62(n)1
    90.67(a)1
      12 (8.11 cM)5
    182631  NM_013614.21  NP_038642.21 
     175448735 
    chicken
    (Gallus gallus)
    Aves ODC11 ornithine decarboxylase 1 78.19(n)
    84.78(a)
      421937  NM_001167766.1  NP_001161238.1 
    lizard
    (Anolis carolinensis)
    Reptilia ODC16
    Uncharacterized protein
    82(a)
    1 ↔ 1
    1(147521088-147561049)
    African clawed frog
    (Xenopus laevis)
    Amphibia odc1-prov2 ornithine decarboxylase 1 77.7(n)    BC044004.1 
    zebrafish
    (Danio rerio)
    Actinopterygii odc12 ornithine decarboxylase 1 73.27(n)   114426  BC047796.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Odc11 , 3 polyamine biosynthesis ornithine
    decarboxylase less3
    Ornithine decarboxylase 11
    46(a)
    (best of 2)3
    51.63(n)1
    48.74(a)1
      44A23
    357661  NM_057704.41  NP_477052.21 
    worm
    (Caenorhabditis elegans)
    Secernentea odc-11 , 3 ornithine decarboxylase3
    Protein ODC-11
    46(a)
    (best of 2)3
    53.99(n)1
    48.18(a)1
      V(6901184-6902556)3
    1790791  NM_072351.51  NP_504752.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPE1(YKL184W)4
    SPE11
    Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation less4
    Spe1p1
    52.38(n)1
    50(a)1
      11(96757-98157)4
    8536511, 4  NP_012737.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os09g05434001 hypothetical protein 49.54(n)
    46.39(a)
      4347746  NM_001070362.2  NP_001063827.2 


    ENSEMBL Gene Tree for ODC1 (if available)
    TreeFam Gene Tree for ODC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ODC1 gene
    ADC2  AZIN12  
    2 SIMAP similar genes for ODC1 using alignment to 3 protein entries:     DCOR_HUMAN (see all proteins):
    ADC    AZIN1

    ODC1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ODC1
    PGOHUM00000235499 PGOHUM00000233565


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/256 SNPs in ODC1 are shown (see all 256)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383927921,2
    --10432240(+) CTTTGC/GGGGAG 1 -- ds50010--------
    rs283624221,2
    C,F--10432253(-) GTGTAC/TCCCCG 1 -- ds50018Minor allele frequency- T:0.13NS NA EA 432
    rs283624211,2
    C,F--10432273(-) TGTGTG/TTTCTT 1 -- ds50015Minor allele frequency- T:0.00NS 190
    rs1811001711,2
    --10432376(+) AATGTC/GGTACC 1 -- ds50010--------
    rs1472757011,2
    --10432382(+) GTACCA/GTATAC 1 -- ds50010--------
    rs283624201,2
    C,F--10432403(-) TGCCTG/ATGAGA 1 -- ds5001 ese36Minor allele frequency- A:0.01NS NA 310
    rs283624191,2
    C,F--10432596(-) TGTGGA/GCGGTG 1 -- ds5001 ese35Minor allele frequency- G:0.00NS 190
    rs168562391,2
    C,F--10432691(+) CTATAC/TGGGAT 1 -- ds5001 ese39Minor allele frequency- T:0.05NA NS WA 446
    rs1176343241,2
    F--10432708(+) ACTGTC/GTGGAA 1 -- ds50011Minor allele frequency- G:0.01EA 120
    rs283624181,2
    C,F,H--10432759(-) ATAAAG/ATATCT 1 -- ut31 ese311Minor allele frequency- A:0.09NS NA WA 1098

    HapMap Linkage Disequilibrium report for ODC1 (10580094 - 10588630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ODC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv873647CNV Loss21882294
    dgv4053n71CNV Loss21882294
    nsv873649CNV Loss21882294
    dgv4052n71CNV Loss21882294
    dgv4051n71CNV Loss21882294
    esv23515CNV Loss19812545


    Human Gene Mutation Database (HGMD): ODC1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ODC1
    DNA2.0 Custom Variant and Variant Library Synthesis for ODC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165640   
    OMIM disorders: 114500  
    20/106 diseases for ODC1 (see all 106):    About MalaCards
    colonic adenoma recurrence, reduced risk of    cerebral artery occlusion    trypanosomiasis    hematologic cancer
    colon adenocarcinoma    gastritis    atrophic gastritis    transient cerebral ischemia
    wallerian degeneration    orotic aciduria    infective endocarditis    sleeping sickness
    colonic polyps    cervical intraepithelial neoplasia    gastric ulcer    chagas disease
    hair loss    familial adenomatous polyposis    placental choriocarcinoma    skin cancer

    5 diseases from the University of Copenhagen DISEASES database for ODC1:
    Sleeping sickness     Colorectal cancer     Papilloma     Carcinoma
    Skin cancer

    ODC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for ODC1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 54.6 39 11163334 (3), 7705952 (2), 18062235 (2), 15818733 (2) (see all 20)
    colon adenocarcinoma 53.1 18 2317797 (2), 19470241 (2), 10816435 (1), 2113770 (1) (see all 8)
    tumors 52.8 335 1951878 (6), 2317797 (6), 9293942 (5), 17582600 (5) (see all 99)
    trypanosomiasis african 52.2 12 7598507 (1), 8347171 (1), 17504214 (1), 20220141 (1) (see all 7)
    ehrlich ascites tumor 52 12 1847813 (3), 7647340 (1), 2384152 (1), 2115438 (1) (see all 6)
    colon tumor 51.4 16 15918191 (5), 2009526 (3), 10395625 (1), 1598217 (1) (see all 7)
    cancer 50.4 127 18339422 (3), 1423312 (3), 8348060 (3), 17957960 (3) (see all 62)
    colon carcinoma 48.7 11 1997467 (1), 1324153 (1), 8444085 (1), 9293942 (1) (see all 8)
    skin tumor 46.9 6 12201673 (1), 8640756 (1), 10874208 (1), 12757023 (1) (see all 5)
    premalignant 45.1 9 9232343 (1), 11564951 (1), 16003136 (1), 8428179 (1) (see all 7)

    Genetic Association Database (GAD): ODC1
    Human Genome Epidemiology (HuGE) Navigator: ODC1 (14 documents)

    Export disorders for ODC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ODC1 gene, integrated from 9 sources (see all 1048):
    (articles sorted by number of sources associating them with ODC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. (PubMed id 10623504)1, 2, 9 Almrud J.J....Hackert M.L. (2000)
    2. Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells. (PubMed id 2317811)1, 2, 9 Hsieh J.T.... Verma A.K. (1990)
    3. Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention. (PubMed id 17047198)1, 4, 9 Barry E.L....O'Brien T.G. (2006)
    4. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. (PubMed id 11461922)1, 2, 9 Bauer P.M.... Ignarro L.J. (2001)
    5. Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. (PubMed id 12810952)1, 4, 9 Martinez M.E....Gerner E.W. (2003)
    6. Associations of a polymorphism in the ornithine decar boxylase gene with colorectal cancer survival. (PubMed id 19789310)1, 4, 9 Zell J.A....Anton-Culver H. (2009)
    7. Genetic polymorphism in ornithine decarboxylase and risk of breast cancer. (PubMed id 19225907)1, 4, 9 Brown I....Schofield A.C. (2009)
    8. Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element. (PubMed id 8519686)1, 2, 9 Wright P.S.... Flanagan M.A. (1995)
    9. Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells. (PubMed id 1598217)1, 2, 9 Moshier J.A.... Flanagan M.A. (1992)
    10. Ornithine decarboxylase-1 polymorphism, chemopreventi on with eflornithine and sulindac, and outcomes among colorectal adenoma patien ts. (PubMed id 20798393)1, 4 Zell J.A....Meyskens F.L. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4953 HGNC: 8109 AceView: ODC1 Ensembl:ENSG00000115758 euGenes: HUgn4953
    ECgene: ODC1 Kegg: 4953 H-InvDB: ODC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ODC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ODC1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/odc1/
    Wikipedia http://en.wikipedia.org/wiki/Ornithine_decarboxylase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ODC1 gene:
    Search GeneIP for patents involving ODC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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