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Aliases for ODC1 Gene

Aliases for ODC1 Gene

  • Ornithine Decarboxylase 1 2 3
  • EC 4.1.1.17 4 63
  • ODC 3 4
  • Ornithine Decarboxylase 3

External Ids for ODC1 Gene

Summaries for ODC1 Gene

Entrez Gene Summary for ODC1 Gene

  • This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

GeneCards Summary for ODC1 Gene

ODC1 (Ornithine Decarboxylase 1) is a Protein Coding gene. Diseases associated with ODC1 include cerebral artery occlusion and trypanosomiasis. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include ornithine decarboxylase activity. An important paralog of this gene is AZIN2.

UniProtKB/Swiss-Prot for ODC1 Gene

  • Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.

Gene Wiki entry for ODC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODC1 Gene

Genomics for ODC1 Gene

Genomic Location for ODC1 Gene

Start:
10,439,968 bp from pter
End:
10,448,554 bp from pter
Size:
8,587 bases
Orientation:
Minus strand

Genomic View for ODC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ODC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODC1 Gene

Regulatory Elements for ODC1 Gene

Proteins for ODC1 Gene

  • Protein details for ODC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11926-DCOR_HUMAN
    Recommended name:
    Ornithine decarboxylase
    Protein Accession:
    P11926
    Secondary Accessions:
    • Q53TU3
    • Q6LDS9

    Protein attributes for ODC1 Gene

    Size:
    461 amino acids
    Molecular mass:
    51148 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Monomer. Does not form an heterodimer with AZIN2 (By similarity). Homodimer.

    Three dimensional structures from OCA and Proteopedia for ODC1 Gene

neXtProt entry for ODC1 Gene

Proteomics data for ODC1 Gene at MOPED

Post-translational modifications for ODC1 Gene

  • S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ODC1 Gene

Gene Families for ODC1 Gene

Suggested Antigen Peptide Sequences for ODC1 Gene

Graphical View of Domain Structure for InterPro Entry

P11926

UniProtKB/Swiss-Prot:

DCOR_HUMAN
Family:
  • Belongs to the Orn/Lys/Arg decarboxylase class-II family.:
    • P11926
genes like me logo Genes that share domains with ODC1: view

Function for ODC1 Gene

Molecular function for ODC1 Gene

GENATLAS Biochemistry: ornithine decarboxylase 1,ornithine metabolism,mitochondrial matrix
UniProtKB/Swiss-Prot CatalyticActivity: L-ornithine = putrescine + CO(2)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by S-nitrosylation. Inhibited by antizyme OAZ1, OAZ2 and OAZ3.
UniProtKB/Swiss-Prot Function: Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.
UniProtKB/Swiss-Prot Induction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Enzyme Numbers (IUBMB) for ODC1 Gene

Gene Ontology (GO) - Molecular Function for ODC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004586 ornithine decarboxylase activity TAS 2317811
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with ODC1: view
genes like me logo Genes that share phenotypes with ODC1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ODC1 Gene

Localization for ODC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ODC1 Gene COMPARTMENTS Subcellular localization image for ODC1 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ODC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ODC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ODC1 Gene

Pathways for ODC1 Gene

genes like me logo Genes that share pathways with ODC1: view

UniProtKB/Swiss-Prot P11926-DCOR_HUMAN

  • Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1

Gene Ontology (GO) - Biological Process for ODC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006595 polyamine metabolic process TAS --
GO:0006596 polyamine biosynthetic process --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with ODC1: view

Compounds for ODC1 Gene

(9) HMDB Compounds for ODC1 Gene

Compound Synonyms Cas Number PubMed IDs
1,3-Diaminopropane
  • 1,3-Diamino-n-propane
109-76-2
Carbon dioxide
  • Carbon oxide
124-38-9
N1-Acetylspermine
  • N'-Acetylspermine
25593-72-0
Norspermidine
  • N-(3-aminopropyl)-1,3-Propanediamine
56-18-8
Ornithine
  • (+)-S-Ornithine
70-26-8

(8) Drugbank Compounds for ODC1 Gene

(6) IUPHAR Ligand for ODC1 Gene

Ligand Type Action Affinity Pubmed IDs
DFMO Inhibitor Inhibition
3-hydroxybenzylhydrazine Inhibitor Inhibition
L-alpha-methyldopa Inhibitor Inhibition
carbidopa Inhibitor Inhibition
APA Inhibitor Inhibition
benserazide Inhibitor Inhibition

(158) Novoseek inferred chemical compound relationships for ODC1 Gene

Compound -log(P) Hits PubMed IDs
ornithine 98.9 336
dfmo 96.3 170
putrescine 94.7 160
spermidine 94.1 128
spermine 92.5 123
genes like me logo Genes that share compounds with ODC1: view

Transcripts for ODC1 Gene

Unigene Clusters for ODC1 Gene

Ornithine decarboxylase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ODC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - -
SP6: - - - - -
SP7:
SP8:
SP9: -
SP10:
SP11: - - - - - - - - -
SP12: - - - - - - -
SP13: -
SP14:

ExUns: 15b ^ 16 ^ 17a · 17b ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ODC1 Gene

GeneLoc Exon Structure for
ODC1
ECgene alternative splicing isoforms for
ODC1

Expression for ODC1 Gene

mRNA expression in normal human tissues for ODC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ODC1 Gene

SOURCE GeneReport for Unigene cluster for ODC1 Gene Hs.467701

genes like me logo Genes that share expressions with ODC1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ODC1 Gene

Orthologs for ODC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ODC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODC1 35
  • 99.57 (n)
  • 99.35 (a)
ODC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 77 (a)
OneToMany
ODC1 35
  • 89.01 (n)
  • 93.49 (a)
ODC1 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ODC1 35
  • 88.94 (n)
  • 95.23 (a)
ODC1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Odc1 35
  • 86.62 (n)
  • 90.67 (a)
Odc1 16
Odc1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ODC1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Odc1 35
  • 86.62 (n)
  • 91.54 (a)
chicken
(Gallus gallus)
Aves ODC1 35
  • 78.19 (n)
  • 84.78 (a)
ODC1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ODC1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia odc1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia odc1 35
  • 74.73 (n)
  • 80.61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5110 35
zebrafish
(Danio rerio)
Actinopterygii odc1 35
  • 67.25 (n)
  • 75.22 (a)
odc1 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011805 35
  • 52.63 (n)
  • 49.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Odc1 35
  • 51.63 (n)
  • 48.74 (a)
Odc1 36
  • 44 (a)
ManyToMany
Odc2 36
  • 41 (a)
ManyToMany
Odc2 37
  • 40 (a)
Odc1 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea F53F10.2 36
  • 24 (a)
OneToMany
odc-1 35
  • 53.91 (n)
  • 48.18 (a)
odc-1 37
  • 46 (a)
F53F10.2a 37
  • 28 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER087C 35
  • 51.52 (n)
  • 47.66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPE1 35
  • 52.38 (n)
  • 50 (a)
SPE1 36
  • 38 (a)
OneToMany
SPE1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02673g 35
  • 54.12 (n)
  • 51.1 (a)
rice
(Oryza sativa)
Liliopsida Os09g0543400 35
  • 49.54 (n)
  • 46.39 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01271 35
  • 53.09 (n)
  • 51.8 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spe1 35
  • 55.18 (n)
  • 55.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10349 36
  • 43 (a)
OneToMany
Species with no ortholog for ODC1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ODC1 Gene

ENSEMBL:
Gene Tree for ODC1 (if available)
TreeFam:
Gene Tree for ODC1 (if available)

Paralogs for ODC1 Gene

Paralogs for ODC1 Gene

Selected SIMAP similar genes for ODC1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ODC1 Gene

genes like me logo Genes that share paralogs with ODC1: view

Variants for ODC1 Gene

Sequence variations from dbSNP and Humsavar for ODC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14589 -- 10,440,442(-) CAGAA(C/T)GGGCC utr-variant-3-prime
rs1049500 -- 10,440,841(-) AACCC(C/T)GACTT reference, synonymous-codon
rs1405948 -- 10,443,034(-) TTTCC(C/T)AGAAG intron-variant
rs1804032 -- 10,441,631(-) CTGCC(C/T)GAAAT synonymous-codon, reference
rs2302613 -- 10,445,176(+) TGGAA(C/T)TGAAA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ODC1 Gene

Variant ID Type Subtype PubMed ID
dgv4051n71 CNV Loss 21882294
dgv4052n71 CNV Loss 21882294
nsv873647 CNV Loss 21882294
dgv4053n71 CNV Loss 21882294
nsv873649 CNV Loss 21882294
esv23515 CNV Loss 19812545

Relevant External Links for ODC1 Gene

HapMap Linkage Disequilibrium report
ODC1
Human Gene Mutation Database (HGMD)
ODC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODC1 Gene

Disorders for ODC1 Gene

(1) OMIM Diseases for ODC1 Gene (165640)

(5) University of Copenhagen DISEASES for ODC1 Gene

(93) Novoseek inferred disease relationships for ODC1 Gene

Disease -log(P) Hits PubMed IDs
colon cancer 54.6 25
colon adenocarcinoma 53.1 10
tumors 52.8 170
trypanosomiasis african 52.2 7
ehrlich ascites tumor 52 8

Relevant External Links for ODC1

Genetic Association Database (GAD)
ODC1
Human Genome Epidemiology (HuGE) Navigator
ODC1
genes like me logo Genes that share disorders with ODC1: view

No data available for UniProtKB/Swiss-Prot for ODC1 Gene

Publications for ODC1 Gene

  1. Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells. (PMID: 1598217) Moshier J.A. … Flanagan M.A. (Nucleic Acids Res. 1992) 3 4 23
  2. Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells. (PMID: 2317811) Hsieh J.T. … Verma A.K. (Cancer Res. 1990) 3 4 23
  3. Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element. (PMID: 8519686) Wright P.S. … Flanagan M.A. (Cell Growth Differ. 1995) 3 4 23
  4. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. (PMID: 11461922) Bauer P.M. … Ignarro L.J. (J. Biol. Chem. 2001) 3 4 23
  5. Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. (PMID: 12810952) Martinez M.E. … Gerner E.W. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 23 48

Products for ODC1 Gene

Sources for ODC1 Gene

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