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ODC1 Gene

protein-coding   GIFtS: 72
GCID: GC02M010580

Ornithine Decarboxylase 1

  See ODC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ornithine Decarboxylase 11 2
ODC2 3
EC 4.1.1.173 8
Ornithine Decarboxylase2

External Ids:    HGNC: 81091   Entrez Gene: 49532   Ensembl: ENSG000001157587   OMIM: 1656405   UniProtKB: P119263   

Export aliases for ODC1 gene to outside databases

Previous GC identifers: GC02M010365 GC02M010631 GC02M010602 GC02M010531 GC02M010497 GC02M010432


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ODC1 Gene:
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to
putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high
turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the
gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. (provided by
RefSeq, Dec 2013)

GeneCards Summary for ODC1 Gene:
ODC1 (ornithine decarboxylase 1) is a protein-coding gene. Diseases associated with ODC1 include colonic adenoma recurrence, reduced risk of, and cerebral artery occlusion. GO annotations related to this gene include ornithine decarboxylase activity. An important paralog of this gene is ADC.

Gene Wiki entry for ODC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ODC1 gene promoter:
         AML1a   Lmo2   Nkx3-1 v1   Ik-3   RORalpha2   PPAR-gamma1   FOXO4   STAT3   PPAR-gamma2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ODC1 promoter sequence
   Search Chromatin IP Primers for ODC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ODC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

ODC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ODC1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M010580:  view genomic region     (about GC identifiers)

Start:
10,580,094 bp from pter      End:
10,588,630 bp from pter
Size:
8,537 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926 (See protein sequence)
Recommended Name: Ornithine decarboxylase  
Size: 461 amino acids; 51148 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
3 PDB 3D structures from and Proteopedia for ODC1:
1D7K (3D)        2ON3 (3D)        2OO0 (3D)    
Secondary accessions: Q53TU3 Q6LDS9

Explore the universe of human proteins at neXtProt for ODC1: NX_P11926

Explore proteomics data for ODC1 at MOPED

Post-translational modifications: 

  • S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ODC1 (P11926) (see all 18)
     ELMKVAR  IWGPTCD  LDIGGGF  SQIKYAA 


    See ODC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001274117.1  NP_001274118.1  NP_001274119.1  NP_002530.1  

    ENSEMBL proteins: 
     ENSP00000234111   ENSP00000385333   ENSP00000390691  
    Reactome Protein details: P11926

    ODC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ODC1
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    GenScript Custom Purified and Recombinant Proteins Services for ODC1
    Novus Biologicals ODC1 Proteins
    Novus Biologicals ODC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ODC1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ODC1 

    ODC1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ODC1
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    Novus Biologicals ODC1 Antibodies
    Abcam antibodies for ODC1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ODC1
    LSBio Antibodies in human, mouse, rat for ODC1

    ODC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ODC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ODC1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ODC1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Ornithine decarboxylase
    Decarboxylases

    Selected InterPro protein domains (see all 7):
     IPR009006 Ala_racemase/Decarboxylase_C
     IPR000183 Orn/DAP/Arg_de-COase
     IPR022657 De-COase2_CS
     IPR002433 Orn_de-COase
     IPR022644 De-COase2_N

    Graphical View of Domain Structure for InterPro Entry P11926

    ProtoNet protein and cluster: P11926

    2 Blocks protein domains:
    IPB000183 Orn/DAP/Arg decarboxylase
    IPB002433 Ornithine decarboxylase signature


    UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926
    Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family


    Find genes that share domains with ODC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCOR_HUMAN, P11926
    Catalytic activity: L-ornithine = putrescine + CO(2)
    Enzyme regulation: Inhibited by S-nitrosylation
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level)

         Genatlas biochemistry entry for ODC1:
    ornithine decarboxylase 1,ornithine metabolism,mitochondrial matrix

         Enzyme Number (IUBMB): EC 4.1.1.171 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004586ornithine decarboxylase activity TAS2317811
         
    Find genes that share ontologies with ODC1           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for ODC1:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Odc1):
     cellular  embryogenesis  mortality/aging  normal 

    Find genes that share phenotypes with ODC1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ODC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ODC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ODC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ODC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ODC1:
    hsa-mir-15a-5p (MIRT051317), hsa-mir-192-5p (MIRT004127), hsa-mir-193b-3p (MIRT041549), hsa-mir-100-5p (MIRT048600), hsa-mir-324-3p (MIRT042942)

    Block miRNA regulation of human, mouse, rat ODC1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ODC1:
    hsa-miR-3163 hsa-miR-3671 hsa-miR-595 hsa-miR-187* hsa-miR-1283 hsa-miR-3914 hsa-miR-587 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidODC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ODC1
    Predesigned siRNA for gene silencing in human, mouse, rat ODC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ODC1

    Clone
    Products:
         
    OriGene clones in human, mouse for ODC1 (see all 6)
    OriGene ORF clones in mouse, rat for ODC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ODC1 (NM_002539)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ODC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODC1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ODC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ODC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ODC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    extracellular2
    mitochondrion2
    nucleus2
    plasma membrane2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ODC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ODC1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    putrescine biosynthesis III0.00
    Metabolism of polyamines0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Arginine and proline metabolism
    Arginine and proline metabolism
    Urea cycle and metabolism of amino groups0.00
    4CDK-mediated phosphorylation and removal of Cdc6
    Regulation of ornithine decarboxylase (ODC)0.80
    5Glutathione metabolism
    Glutathione metabolism0.65


    Find genes that share SuperPaths with ODC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ODC1
        Validated targets of C-MYC transcriptional activation
    Urea cycle and metabolism of amino groups
    putrescine biosynthesis III

    2 Reactome Pathways for ODC1
        Regulation of ornithine decarboxylase (ODC)
    Metabolism of polyamines


    3 Kegg Pathways  (Kegg details for ODC1):
        Arginine and proline metabolism
    Glutathione metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926
    Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from
    L-ornithine: step 1/1

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ODC1: 

              Nephrotoxicity in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ODC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ODC1 (P119261, 2, 3 ENSP000002341114) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253495 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253495 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253495 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253495 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253495 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development IEA--
    GO:0006521regulation of cellular amino acid metabolic process TAS--
    GO:0006595polyamine metabolic process TAS--
    GO:0006596polyamine biosynthetic process ----
    GO:0008284positive regulation of cell proliferation IEA--

    Find genes that share ontologies with ODC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ODC1
      Browse compounds at ApexBio 

    Browse Tocris compounds for ODC1 (DCOR)

    9 HMDB Compounds for ODC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    1,3-Diaminopropane1,3-Diamino-n-propane (see all 8)109-76-2--
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Ornithine(+)-S-Ornithine (see all 9)70-26-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    8 DrugBank Compounds for ODC1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Spermine1, 4-Bis(aminopropyl)butanediamine (see all 5)71-44-3targetproduct of11160858 10712236 10698696 11413269 21140446 11408092
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor12460114 11683631 12627959 12672797 15476392
    Alpha-Difluoromethylornithine-- --target--17139284 17016423 10592235
    G418-- 49863-47-0target--17139284 17016423 10592235
    N-Pyridoxyl-Glycine-5-Monophosphate-- --target--17139284 17016423 10592235
    Putrescine-- 110-60-1target--17139284 17016423 10592235
    Pyridoxine-5'-Phosphate-- 447-05-2target--17139284 17016423 10592235
    N'-Pyridoxyl-Lysine-5'-Monophosphate-- --target--17139284 17016423

    6 IUPHAR Ligands for ODC1 (Ornithine decarboxylase)    About this table
    LigandTypeActionAffinityPubmed IDs
    DFMO
    InhibitorInhibition--
    3-hydroxybenzylhydrazine
    InhibitorInhibition--
    L-alpha-methyldopa
    InhibitorInhibition--
    carbidopa
    InhibitorInhibition--
    APA
    InhibitorInhibition--
    benserazide
    InhibitorInhibition--

    Selected Novoseek inferred chemical compound relationships for ODC1 gene (see all 158)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ornithine 98.9 2890 11461922 (8), 8719885 (8), 1872891 (7), 8354283 (7) (see all 99)
    dfmo 96.3 540 7646459 (5), 8221660 (5), 1932110 (4), 19047162 (4) (see all 99)
    putrescine 94.7 273 1952937 (6), 8719885 (6), 2146783 (5), 1545142 (5) (see all 99)
    spermidine 94.1 239 1872863 (4), 2241982 (4), 8486633 (4), 11123206 (3) (see all 99)
    spermine 92.5 185 2127337 (5), 2344358 (5), 11123206 (4), 1573975 (3) (see all 99)
    s-adenosylmethionine 83 130 7954423 (3), 2314049 (2), 1930914 (2), 1499693 (2) (see all 84)
    1-aminooxy-3-aminopropane 80.1 9 17407445 (2), 8462122 (1), 11163334 (1), 7896733 (1)
    denspm 78.7 10 8371417 (1), 10951496 (1), 7954423 (1), 19097065 (1) (see all 5)
    sam 486a 77.5 4 15547724 (1), 15704548 (1), 8877009 (1)
    n1-acetylspermidine 75.5 1 12355213 (1)



    Find genes that share compounds with ODC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ODC1 gene (4 alternative transcripts): 
    NM_001287188.1  NM_001287189.1  NM_001287190.1  NM_002539.2  

    Unigene Cluster for ODC1:

    Ornithine decarboxylase 1
    Hs.467701  [show with all ESTs]
    Unigene Representative Sequence: NM_002539
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234111(uc002rao.1 uc010yjd.1) ENST00000405333(uc010exg.1)
    ENST00000446285 ENST00000443218(uc010exh.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ODC1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ODC1:
    hsa-miR-3163 hsa-miR-3671 hsa-miR-595 hsa-miR-187* hsa-miR-1283 hsa-miR-3914 hsa-miR-587 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidODC1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ODC1
    Predesigned siRNA for gene silencing in human, mouse, rat ODC1
    Clone
    Products:
         
    OriGene clones in human, mouse for ODC1 (see all 6)
    OriGene ORF clones in mouse, rat for ODC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ODC1 (NM_002539)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ODC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODC1
    Primer
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    OriGene qPCR primer pairs and template standards for ODC1
    OriGene qSTAR qPCR primer pairs in human, mouse for ODC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ODC1
      QuantiTect SYBR Green Assays in human, mouse, rat ODC1
      QuantiFast Probe-based Assays in human, mouse, rat ODC1

    Additional mRNA sequence: 

    AK292352.1 AK301956.1 AK312766.1 BC014562.2 BC025296.1 D28365.1 DQ185043.1 M16650.2 
    M20372.1 X55362.1 

    Selected DOTS entries (see all 37):

    DT.40254377  DT.100669014  DT.95110200  DT.100880136  DT.120936261  DT.120936299  DT.100762913  DT.40125078 
    DT.92462214  DT.92462225  DT.85104235  DT.100659486  DT.92462212  DT.95197533  DT.100039111  DT.100880128 
    DT.95197532  DT.100705807  DT.100771956  DT.100880124  DT.100880142  DT.120936269  DT.120936276  DT.120936288 

    Selected AceView cDNA sequences (see all 834):

    BE298146 CF131875 AW368315 BC025296 BE856871 AA761535 BQ775597 BI091315 
    BQ676823 BQ423032 BU147064 BG403749 BM699693 AA344435 AW173464 BU553582 
    BM799921 BM790890 BU930985 BG681261 BQ881663 BM798853 M16650 M20372 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ODC1 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
    SP1:                                      -     -     -     -                                                                                         -     -   
    SP2:              -     -     -     -     -     -     -     -                                                                                                   
    SP3:                          -     -     -     -     -     -                                                                                                   
    SP4:                                                  -     -                                                                                                   
    SP5:                                      -     -     -     -     -     -                                                                                       

    ExUns: 15b ^ 16 ^ 17a · 17b ^ 18
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for ODC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ODC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCAGCCAT
    ODC1 Expression
    About this image


    ODC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
     
     Thymus (Hematopoietic System)
             Thymus
    ODC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ODC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467701
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ODC1: 
              Nephrotoxicity in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Osmotic Stress in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat ODC1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ODC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ODC1 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Odc11 , 5 ornithine decarboxylase, structural 11, 5 86.62(n)1
    90.67(a)1
      12 (8.11 cM)5
    182631  NM_013614.21  NP_038642.21 
     175448735 
    chicken
    (Gallus gallus)
    Aves ODC11 ornithine decarboxylase 1 78.19(n)
    84.78(a)
      421937  NM_001167766.1  NP_001161238.1 
    lizard
    (Anolis carolinensis)
    Reptilia ODC16
    ornithine decarboxylase 1
    82(a)
    1 ↔ 1
    1(147521088-147561049)
    African clawed frog
    (Xenopus laevis)
    Amphibia odc1-prov2 ornithine decarboxylase 1 77.7(n)    BC044004.1 
    zebrafish
    (Danio rerio)
    Actinopterygii odc12 ornithine decarboxylase 1 73.27(n)   114426  BC047796.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Odc11 , 3 polyamine biosynthesis ornithine
    decarboxylase3
    Ornithine decarboxylase 11
    46(a)
    (best of 2)3
    51.63(n)1
    48.74(a)1
      44A23
    357661  NM_057704.41  NP_477052.21 
    worm
    (Caenorhabditis elegans)
    Secernentea odc-11 , 3 ornithine decarboxylase3
    odc-11
    46(a)
    (best of 2)3
    53.91(n)1
    48.18(a)1
      V(6901184-6902556)3
    1790791  NM_072351.61  NP_504752.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPE1(YKL184W)4
    SPE11
    Ornithine decarboxylase, catalyzes the first step in more4
    SPE11
    52.38(n)1
    50(a)1
      11(96757-98157)4
    8536511, 4  NP_012737.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os09g05434001 Os09g0543400 49.54(n)
    46.39(a)
      4347746  NM_001070362.2  NP_001063827.2 


    ENSEMBL Gene Tree for ODC1 (if available)
    TreeFam Gene Tree for ODC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ODC1 gene
    ADC2  AZIN12  
    2 SIMAP similar genes for ODC1 using alignment to 3 protein entries:     DCOR_HUMAN (see all proteins):
    ADC    AZIN1

    Find genes that share paralogs with ODC1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ODC1
    PGOHUM00000235499 PGOHUM00000233565


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ODC1 (see all 256)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383927921,2
    --10432240(+) CTTTGC/GGGGAG 1 -- ds50010--------
    rs283624221,2
    C,F--10432253(-) GTGTAC/TCCCCG 1 -- ds50018Minor allele frequency- T:0.13NS NA EA 432
    rs283624211,2
    C,F--10432273(-) TGTGTG/TTTCTT 1 -- ds50015Minor allele frequency- T:0.00NS 190
    rs1811001711,2
    --10432376(+) AATGTC/GGTACC 1 -- ds50010--------
    rs1472757011,2
    --10432382(+) GTACCA/GTATAC 1 -- ds50010--------
    rs283624201,2
    C,F--10432403(-) TGCCTG/ATGAGA 1 -- ds5001 ese36Minor allele frequency- A:0.01NS NA 310
    rs283624191,2
    C,F--10432596(-) TGTGGA/GCGGTG 1 -- ds5001 ese35Minor allele frequency- G:0.00NS 190
    rs168562391,2
    C,F--10432691(+) CTATAC/TGGGAT 1 -- ds5001 ese39Minor allele frequency- T:0.05NA NS WA 446
    rs1176343241,2
    F--10432708(+) ACTGTC/GTGGAA 1 -- ds50011Minor allele frequency- G:0.01EA 120
    rs283624181,2
    C,F,H--10432759(-) ATAAAG/ATATCT 1 -- ut31 ese311Minor allele frequency- A:0.09NS NA WA 1098

    HapMap Linkage Disequilibrium report for ODC1 (10580094 - 10588630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ODC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873647CNV Loss21882294
    dgv4053n71CNV Loss21882294
    nsv873649CNV Loss21882294
    dgv4052n71CNV Loss21882294
    dgv4051n71CNV Loss21882294
    esv23515CNV Loss19812545

    Human Gene Mutation Database (HGMD): ODC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ODC1
    DNA2.0 Custom Variant and Variant Library Synthesis for ODC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165640   
    OMIM disorders: 114500  
    17 diseases for ODC1:    
    About MalaCards
    colonic adenoma recurrence, reduced risk of    cerebral artery occlusion    transient cerebral ischemia    trypanosomiasis
    wallerian degeneration    orotic aciduria    colon adenocarcinoma    sleeping sickness
    colorectal adenoma    gastritis    gastric ulcer    cervical intraepithelial neoplasia
    atrophic gastritis    familial adenomatous polyposis    chagas disease    colon cancer
    malaria

    5 diseases from the University of Copenhagen DISEASES database for ODC1:
    Sleeping sickness     Colorectal cancer     Papilloma     Carcinoma
    Skin cancer

    Find genes that share disorders with ODC1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ODC1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 54.6 39 11163334 (3), 7705952 (2), 18062235 (2), 15818733 (2) (see all 20)
    colon adenocarcinoma 53.1 18 2317797 (2), 19470241 (2), 10816435 (1), 2113770 (1) (see all 8)
    tumors 52.8 335 1951878 (6), 2317797 (6), 9293942 (5), 17582600 (5) (see all 99)
    trypanosomiasis african 52.2 12 7598507 (1), 8347171 (1), 17504214 (1), 20220141 (1) (see all 7)
    ehrlich ascites tumor 52 12 1847813 (3), 7647340 (1), 2384152 (1), 2115438 (1) (see all 6)
    colon tumor 51.4 16 15918191 (5), 2009526 (3), 10395625 (1), 1598217 (1) (see all 7)
    cancer 50.4 127 18339422 (3), 1423312 (3), 8348060 (3), 17957960 (3) (see all 62)
    colon carcinoma 48.7 11 1997467 (1), 1324153 (1), 8444085 (1), 9293942 (1) (see all 8)
    skin tumor 46.9 6 12201673 (1), 8640756 (1), 10874208 (1), 12757023 (1) (see all 5)
    premalignant 45.1 9 9232343 (1), 11564951 (1), 16003136 (1), 8428179 (1) (see all 7)

    Genetic Association Database (GAD): ODC1
    Human Genome Epidemiology (HuGE) Navigator: ODC1 (14 documents)

    Export disorders for ODC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ODC1 gene, integrated from 10 sources (see all 1052):
    (articles sorted by number of sources associating them with ODC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. (PubMed id 10623504)1, 2, 9 Almrud J.J....Hackert M.L. (J. Mol. Biol. 2000)
    2. Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells. (PubMed id 2317811)1, 2, 9 Hsieh J.T.... Verma A.K. (Cancer Res. 1990)
    3. Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention. (PubMed id 17047198)1, 4, 9 Barry E.L....O'Brien T.G. (J. Natl. Cancer Inst. 2006)
    4. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. (PubMed id 11461922)1, 2, 9 Bauer P.M.... Ignarro L.J. (J. Biol. Chem. 2001)
    5. Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. (PubMed id 12810952)1, 4, 9 Martinez M.E....Gerner E.W. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    6. Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. (PubMed id 19789310)1, 4, 9 Zell J.A....Anton-Culver H. (Clin. Cancer Res. 2009)
    7. Genetic polymorphism in ornithine decarboxylase and risk of breast cancer. (PubMed id 19225907)1, 4, 9 Brown I....Schofield A.C. (Fam. Cancer 2009)
    8. Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element. (PubMed id 8519686)1, 2, 9 Wright P.S.... Flanagan M.A. (Cell Growth Differ. 1995)
    9. Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells. (PubMed id 1598217)1, 2, 9 Moshier J.A.... Flanagan M.A. (Nucleic Acids Res. 1992)
    10. Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients. (PubMed id 20798393)1, 4 Zell J.A....Meyskens F.L. (J. Natl. Cancer Inst. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4953 HGNC: 8109 AceView: ODC1 Ensembl:ENSG00000115758 euGenes: HUgn4953
    ECgene: ODC1 Kegg: 4953 H-InvDB: ODC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ODC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ODC1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/odc1/
    Wikipedia http://en.wikipedia.org/wiki/Ornithine_decarboxylase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ODC1 gene:
    Search GeneIP for patents involving ODC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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