ODC1 Gene
protein-coding GIFtS: 73
GCID: GC02M010580
|
|
ornithine decarboxylase 1
| |
Aliases
for ODC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ornithine Decarboxylase 11 2 | | ODC1 2 3 | | EC 4.1.1.173 8 | | Ornithine Decarboxylase2 |
Export aliases for ODC1 gene to outside databasesPrevious GC identifers: GC02M010365 GC02M010631 GC02M010602 GC02M010531 GC02M010497 GC02M010432 |
Summaries
for ODC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ODC1:
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine toputrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a highturnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the geneencoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. (provided byRefSeq, Jul 2008)
Gene Wiki entry for ODC1
|
Genomic Views
for ODC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005334.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ODC1 gene promoter:
AML1a Lmo2 Nkx3-1 v1 Ik-3 RORalpha2 PPAR-gamma1 FOXO4 STAT3 PPAR-gamma2 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ODC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ODC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p25 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25ODC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M010580: view genomic region
(about GC identifiers)
Start:
|
10,580,094 bp from pter |
End:
|
10,588,630 bp from pter |
Size:
|
8,537 bases |
Orientation:
|
minus strand |
|
Proteins
for ODC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926 (See
protein sequence)Recommended Name: Ornithine decarboxylase Size: 461 amino acids; 51148 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
3 PDB 3D structures from  and Proteopedia  for ODC1:1D7K (3D)
2ON3 (3D)
2OO0 (3D)
Secondary accessions: Q53TU3 Q6LDS9Explore the universe of human proteins at neXtProt for ODC1: NX_P11926
Post-translational modifications:
S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P11926
4/18 DME Specific Peptides for ODC1 (P11926) (see all 18)
ODC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002530.1
ENSEMBL proteins: ENSP00000234111 ENSP00000385333 ENSP00000390691 Reactome Protein details: P11926
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ODC1 for ontologies About GeneDecksing
ODC1 Antibody Products:
Assay Products for ODC1: |
Protein
Domains /
Families
for ODC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ODC1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P11926ProtoNet protein and cluster: P11926 2 Blocks protein families: IPB000183 Orn/DAP/Arg decarboxylase IPB002433 Ornithine decarboxylase signature
UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family |
Function
for ODC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926Catalytic activity: L-ornithine = putrescine + CO(2)Enzyme regulation: Inhibited by S-nitrosylationInduction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level) Genatlas biochemistry entry for ODC1:ornithine decarboxylase 1,ornithine metabolism,mitochondrial matrix
Enzyme Number (IUBMB): EC 4.1.1.171 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ODC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ODC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ODC1 (NM_002539) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ODC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ODC1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004586 | ornithine decarboxylase activity |
TAS | 2317811 |
ODC1 for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for ODC1:
Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Odc1):
ODC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ODC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Arginine and proline metabolism | | | 3 | Ubiquitinated Orc1 is degraded by the proteasome | | | 4 | Metabolism of amino acids and derivatives | | | 5 | Validated targets of C-MYC transcriptional activation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  BioSystems Pathways for ODC1
5 
Reactome Pathways for ODC1
3 
Kegg Pathways (Kegg details for ODC1):
UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine fromL-ornithine: step 1/1
ODC1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ODC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/94 Interacting proteins for ODC1 (P119261, 2, 3 ENSP000002341114) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001822 | kidney development |
IEA | -- | | GO:0006521 | regulation of cellular amino acid metabolic process |
TAS | -- | | GO:0006595 | polyamine metabolic process |
TAS | -- | | GO:0006596 | polyamine biosynthetic process |
NAS | -- | | GO:0008284 | positive regulation of cell proliferation |
IEA | -- |
ODC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ODC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ODC1 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for ODC1 |
 Browse Tocris compounds for ODC1
9 HMDB Compounds for ODC1 About this table
8 DrugBank Compounds for ODC1 About this table
10/158 Novoseek chemical compound relationships for ODC1 gene (see all 158) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ornithine |
98.9 |
2890 |
11461922 (8), 8719885 (8), 1872891 (7), 8354283 (7) (see all 99) |
| dfmo |
96.3 |
540 |
7646459 (5), 8221660 (5), 1932110 (4), 19047162 (4) (see all 99) |
| putrescine |
94.7 |
273 |
1952937 (6), 8719885 (6), 2146783 (5), 1545142 (5) (see all 99) |
| spermidine |
94.1 |
239 |
1872863 (4), 2241982 (4), 8486633 (4), 11123206 (3) (see all 99) |
| spermine |
92.5 |
185 |
2127337 (5), 2344358 (5), 11123206 (4), 1573975 (3) (see all 99) |
| s-adenosylmethionine |
83 |
130 |
7954423 (3), 2314049 (2), 1930914 (2), 1499693 (2) (see all 84) |
| 1-aminooxy-3-aminopropane |
80.1 |
9 |
17407445 (2), 8462122 (1), 11163334 (1), 7896733 (1) |
| denspm |
78.7 |
10 |
8371417 (1), 10951496 (1), 7954423 (1), 19097065 (1) (see all 5) |
| sam 486a |
77.5 |
4 |
15547724 (1), 15704548 (1), 8877009 (1) |
| n1-acetylspermidine |
75.5 |
1 |
12355213 (1) |
Search CenterWatch for drugs/clinical trials and news about ODC1 / DCOR
|
Transcripts
for ODC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ODC1 gene: NM_002539.1 Unigene Cluster for ODC1: Ornithine decarboxylase 1 Hs.467701 [show with all ESTs]Unigene Representative Sequence: NM_0025394 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000234111(uc002rao.1 uc010yjd.1) ENST00000405333(uc010exg.1)
ENST00000446285 ENST00000443218(uc010exh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ODC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ODC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ODC1 (NM_002539) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ODC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODC1 |
Additional cDNA sequence: AK292352.1 AK301956.1 AK312766.1 BC014562.2 BC025296.1 D28365.1 DQ185043.1 M16650.2 M20372.1 X55362.1 24/37 DOTS entries (see all 37): DT.40254377 DT.100669014 DT.95110200 DT.100880136 DT.120936261 DT.120936299 DT.100762913 DT.40125078 DT.92462214 DT.92462225 DT.85104235 DT.100659486 DT.92462212 DT.95197533 DT.100039111 DT.100880128 DT.95197532 DT.100705807 DT.100771956 DT.100880124 DT.100880142 DT.120936269 DT.120936276 DT.120936288 24/834 AceView cDNA sequences (see all 834): BQ421820 BQ064242 BU727301 BU556791 BQ018216 CF131875 BQ423032 BU854730 BQ721981 BG394254 AW675526 BU688315 BU181893 BM799921 BG686916 CB216477 BE779234 BI826443 AL514594 AI061312 BQ059186 BM667082 BQ014883 BE728546
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ODC1 (see all 14) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | |
| SP2: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for ODC1
|
Expression
for ODC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ODC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCAGCCAT
About this image
See ODC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ODC1
SOURCE GeneReport for Unigene cluster: Hs.467701
SABiosciences Expression via Pathway-Focused PCR Arrays including ODC1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ODC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ODC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ODC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ODC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ODC1 |
Orthologs
for ODC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for ODC1 gene from 10/38 species (see all 38) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ODC11 |
ornithine decarboxylase 1 |
78.19(n)
84.78(a) |
|
421937 NM_001167766.1 NP_001161238.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ODC16 |
-- |
87(a) |
1 ↔ 1 |
1(147553131-147560117) |
African clawed frog
(Xenopus laevis) |
Amphibia |
odc1-prov2 |
ornithine decarboxylase 1 |
77.7(n) |
|
BC044004.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
odc12 |
ornithine decarboxylase 1 |
73.27(n) |
|
114426 BC047796.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Odc11 , 3 |
polyamine biosynthesis ornithine
decarboxylase3
Ornithine decarboxylase 11 |
46(a)
(best of 2)3
51.63(n)1
48.74(a)1 |
|
44A23
357661 NM_057704.41 NP_477052.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
odc-11 , 3 |
ornithine decarboxylase3
Protein ODC-11 |
46(a)
(best of 2)3
53.99(n)1
48.18(a)1 |
|
V(6901184-6902556)3
1790791 NM_072351.51 NP_504752.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SPE1(YKL184W)4
SPE11 |
Ornithine decarboxylase, catalyzes the first step in more4
Spe1p1 |
52.38(n)1
50(a)1 |
|
11(96757-98157)4
8536511, 4 NP_012737.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G118806AT3G143906 |
diaminopimelate decarboxylase 1 |
17(a)17(a) |
possible orthologpossible ortholog |
5(3827526-3829986) 3(4806725-4809433) |
rice
(Oryza sativa) |
Liliopsida |
Os09g05434001 |
hypothetical protein |
49.54(n)
46.39(a) |
|
4347746 NM_001070362.2 NP_001063827.2 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
lysA6 |
diaminopimelate decarboxylase, PLP-binding |
15(a) |
possible ortholog |
Chromosome(2975659-2976921) |
ENSEMBL Gene Tree for ODC1 (if available)
TreeFam Gene Tree for ODC1 (if available) |
Paralogs
for ODC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ODC1 gene
- ADC2 AZIN12
2 SIMAP similar genes for ODC1 using alignment to 3 protein entries: DCOR_HUMAN (see all proteins):ADC AZIN1
ODC1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ODC1
PGOHUM00000235499 PGOHUM00000233565
|
Genomic Variants
for ODC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ODC1 (10580094 - 10588630 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ODC1
1 CNV: 72633
Human Gene Mutation Database (HGMD): ODC1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ODC1 |
|
Disorders
/ Diseases
for ODC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ODC1 for disorders About GeneDecksing
OMIM gene information: 165640
OMIM disorders: 114500
20/119  diseases for ODC1 (see all 119): About MalaCardscolonic adenoma recurrence, reduced risk of dermoid cyst peutz-jeghers syndrome familial adenomatous polyposis
cervical intraepithelial neoplasia wallerian degeneration transient cerebral ischemia xeroderma pigmentosum
dna topoisomerase ii barrett's esophagus cerebral artery occlusion autoimmune hemolytic anemia
iron overload hemolytic anemia anaplastic astrocytoma atrophic gastritis
sleeping sickness colonic polyps gastritis placental choriocarcinoma
3 diseases from the University of Copenhagen DISEASES database for ODC1:Sleeping sickness Papilloma Colorectal cancer 10/93 Novoseek disease relationships for ODC1 gene (see all 93) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| colon cancer |
54.6 |
39 |
11163334 (3), 7705952 (2), 18062235 (2), 15818733 (2) (see all 20) |
| colon adenocarcinoma |
53.1 |
18 |
2317797 (2), 19470241 (2), 10816435 (1), 2113770 (1) (see all 8) |
| tumors |
52.8 |
335 |
1951878 (6), 2317797 (6), 9293942 (5), 17582600 (5) (see all 99) |
| trypanosomiasis african |
52.2 |
12 |
7598507 (1), 8347171 (1), 17504214 (1), 20220141 (1) (see all 7) |
| ehrlich ascites tumor |
52 |
12 |
1847813 (3), 7647340 (1), 2384152 (1), 2115438 (1) (see all 6) |
| colon tumor |
51.4 |
16 |
15918191 (5), 2009526 (3), 10395625 (1), 1598217 (1) (see all 7) |
| cancer |
50.4 |
127 |
18339422 (3), 1423312 (3), 8348060 (3), 17957960 (3) (see all 62) |
| colon carcinoma |
48.7 |
11 |
1997467 (1), 1324153 (1), 8444085 (1), 9293942 (1) (see all 8) |
| skin tumor |
46.9 |
6 |
12201673 (1), 8640756 (1), 10874208 (1), 12757023 (1) (see all 5) |
| premalignant |
45.1 |
9 |
9232343 (1), 11564951 (1), 16003136 (1), 8428179 (1) (see all 7) |
Genetic Association Database (GAD): ODC1
Human Genome Epidemiology (HuGE) Navigator: ODC1 (14 documents)
Export disorders for ODC1 gene to outside databases
|
Publications
for ODC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for ODC1 gene, integrated from 9 sources (see all 1044):
(articles sorted by number of sources associating them with ODC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. (PubMed id 10623504)1, 2, 9 Almrud J.J....Hackert M.L. (2000)
- Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells. (PubMed id 2317811)1, 2, 9 Hsieh J.T.... Verma A.K. (1990)
- Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. (PubMed id 11461922)1, 2, 9 Bauer P.M.... Ignarro L.J. (2001)
- Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. (PubMed id 12810952)1, 4, 9 Martinez M.E....Gerner E.W. (2003)
- Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element. (PubMed id 8519686)1, 2, 9 Wright P.S.... Flanagan M.A. (1995)
- Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells. (PubMed id 1598217)1, 2, 9 Moshier J.A.... Flanagan M.A. (1992)
- Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (2006)
- Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population. (PubMed id 15734972)1, 4 You W.C....Gail M.H. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene. (PubMed id 2227439)1, 2 Hickok N.J.... Jaenne O.A. (1990)
|
External Searches for ODC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing ODC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ODC1 gene
(According to HUGE)
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| -- |
Specialized Databases showing ODC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ODC1 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for ODC1 | Genetics and Cytogenetics in Oncology and Haematology | | NIEHS-SNPs | http://egp.gs.washington.edu/data/odc1/ | | Wikipedia | http://en.wikipedia.org/wiki/Ornithine_decarboxylase |
|
| | |
About This Section
| Patent Information for ODC1 gene:
Search GeneIP for patents involving ODC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ODC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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