Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ODC1 Gene

Aliases for ODC1 Gene

  • Ornithine Decarboxylase 1 2 3
  • EC 4.1.1.17 4 63
  • ODC 3 4

External Ids for ODC1 Gene

Previous GeneCards Identifiers for ODC1 Gene

  • GC02M010365
  • GC02M010631
  • GC02M010602
  • GC02M010531
  • GC02M010497
  • GC02M010580

Summaries for ODC1 Gene

Entrez Gene Summary for ODC1 Gene

  • This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

GeneCards Summary for ODC1 Gene

ODC1 (Ornithine Decarboxylase 1) is a Protein Coding gene. Diseases associated with ODC1 include cerebral artery occlusion and transient cerebral ischemia. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include protein homodimerization activity and ornithine decarboxylase activity. An important paralog of this gene is AZIN2.

UniProtKB/Swiss-Prot for ODC1 Gene

  • Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.

Gene Wiki entry for ODC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODC1 Gene

Genomics for ODC1 Gene

Regulatory Elements for ODC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ODC1 Gene

Chromosome:
2
Start:
10,439,968 bp from pter
End:
10,448,554 bp from pter
Size:
8,587 bases
Orientation:
Minus strand

Genomic View for ODC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ODC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODC1 Gene

Proteins for ODC1 Gene

  • Protein details for ODC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11926-DCOR_HUMAN
    Recommended name:
    Ornithine decarboxylase
    Protein Accession:
    P11926
    Secondary Accessions:
    • Q53TU3
    • Q6LDS9

    Protein attributes for ODC1 Gene

    Size:
    461 amino acids
    Molecular mass:
    51148 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Monomer. Does not form an heterodimer with AZIN2 (By similarity). Homodimer.

    Three dimensional structures from OCA and Proteopedia for ODC1 Gene

neXtProt entry for ODC1 Gene

Proteomics data for ODC1 Gene at MOPED

Post-translational modifications for ODC1 Gene

  • S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODC1 Gene

Antibody Products

Domains & Families for ODC1 Gene

Gene Families for ODC1 Gene

Suggested Antigen Peptide Sequences for ODC1 Gene

Graphical View of Domain Structure for InterPro Entry

P11926

UniProtKB/Swiss-Prot:

DCOR_HUMAN :
  • Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Family:
  • Belongs to the Orn/Lys/Arg decarboxylase class-II family.
genes like me logo Genes that share domains with ODC1: view

Function for ODC1 Gene

Molecular function for ODC1 Gene

GENATLAS Biochemistry:
ornithine decarboxylase 1,ornithine metabolism,mitochondrial matrix
UniProtKB/Swiss-Prot CatalyticActivity:
L-ornithine = putrescine + CO(2)
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by S-nitrosylation. Inhibited by antizyme OAZ1, OAZ2 and OAZ3.
UniProtKB/Swiss-Prot Function:
Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Enzyme Numbers (IUBMB) for ODC1 Gene

Gene Ontology (GO) - Molecular Function for ODC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004586 ornithine decarboxylase activity TAS 2317811
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with ODC1: view
genes like me logo Genes that share phenotypes with ODC1: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ODC1 Gene

Localization for ODC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ODC1 Gene COMPARTMENTS Subcellular localization image for ODC1 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ODC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with ODC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ODC1 Gene

Pathways & Interactions for ODC1 Gene

genes like me logo Genes that share pathways with ODC1: view

PCR Array Products

UniProtKB/Swiss-Prot P11926-DCOR_HUMAN

  • Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1

Gene Ontology (GO) - Biological Process for ODC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006595 polyamine metabolic process TAS --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0009446 putrescine biosynthetic process --
genes like me logo Genes that share ontologies with ODC1: view

No data available for SIGNOR curated interactions for ODC1 Gene

Drugs & Compounds for ODC1 Gene

(87) Drugs for ODC1 Gene - From: NovoSeek, HMDB, DrugBank, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
spermine Approved Nutra Channel blocker, Target, product of 0
Ornithine Approved Nutra Full agonist, Agonist 31
Carbidopa Approved Pharma Inhibition, Inhibitor 144
Acitretin Approved Pharma Metabolite of etretinate 29
Amiloride Approved Pharma Channel blocker 45

(86) Additional Compounds for ODC1 Gene - From: HMDB, NovoSeek, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
124-38-9
DFMO
Inhibition, Inhibitor 68278-23-9
L-alpha-methyldopa
Inhibition, Inhibitor
1,3-diaminopropane
  • 1,3-Diamino-N-propane
  • 1,3-Propanediamine
  • 1,3-Propylenediamine
  • 1,3-Trimethylenediamine
  • 3-Aminopropylamine
109-76-2
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
genes like me logo Genes that share compounds with ODC1: view

Transcripts for ODC1 Gene

Unigene Clusters for ODC1 Gene

Ornithine decarboxylase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ODC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - -
SP6: - - - - -
SP7:
SP8:
SP9: -
SP10:
SP11: - - - - - - - - -
SP12: - - - - - - -
SP13: -
SP14:

ExUns: 15b ^ 16 ^ 17a · 17b ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ODC1 Gene

GeneLoc Exon Structure for
ODC1
ECgene alternative splicing isoforms for
ODC1

Expression for ODC1 Gene

mRNA expression in normal human tissues for ODC1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ODC1 Gene



SOURCE GeneReport for Unigene cluster for ODC1 Gene Hs.467701

genes like me logo Genes that share expression patterns with ODC1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ODC1 Gene

Orthologs for ODC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ODC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ODC1 35
  • 89.01 (n)
  • 93.49 (a)
-- 36
  • 77 (a)
OneToMany
ODC1 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ODC1 35
  • 88.94 (n)
  • 95.23 (a)
ODC1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Odc1 35
  • 86.62 (n)
  • 90.67 (a)
Odc1 16
Odc1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ODC1 35
  • 99.57 (n)
  • 99.35 (a)
ODC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Odc1 35
  • 86.62 (n)
  • 91.54 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ODC1 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves ODC1 35
  • 78.19 (n)
  • 84.78 (a)
ODC1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ODC1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia odc1 35
  • 74.73 (n)
  • 80.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia odc1-prov 35
zebrafish
(Danio rerio)
Actinopterygii odc1 35
  • 67.25 (n)
  • 75.22 (a)
odc1 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5110 35
fruit fly
(Drosophila melanogaster)
Insecta Odc1 37
  • 46 (a)
Odc2 37
  • 40 (a)
Odc1 35
  • 51.63 (n)
  • 48.74 (a)
Odc1 36
  • 44 (a)
ManyToMany
Odc2 36
  • 41 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011805 35
  • 52.63 (n)
  • 49.87 (a)
worm
(Caenorhabditis elegans)
Secernentea F53F10.2a 37
  • 28 (a)
odc-1 37
  • 46 (a)
odc-1 35
  • 53.91 (n)
  • 48.18 (a)
F53F10.2 36
  • 24 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER087C 35
  • 51.52 (n)
  • 47.66 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02673g 35
  • 54.12 (n)
  • 51.1 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPE1 35
  • 52.38 (n)
  • 50 (a)
SPE1 36
  • 38 (a)
OneToMany
SPE1 38
rice
(Oryza sativa)
Liliopsida Os09g0543400 35
  • 49.54 (n)
  • 46.39 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01271 35
  • 53.09 (n)
  • 51.8 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spe1 35
  • 55.18 (n)
  • 55.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10349 36
  • 43 (a)
OneToMany
Species with no ortholog for ODC1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ODC1 Gene

ENSEMBL:
Gene Tree for ODC1 (if available)
TreeFam:
Gene Tree for ODC1 (if available)

Paralogs for ODC1 Gene

Paralogs for ODC1 Gene

(2) SIMAP similar genes for ODC1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ODC1 Gene

genes like me logo Genes that share paralogs with ODC1: view

Variants for ODC1 Gene

Sequence variations from dbSNP and Humsavar for ODC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14589 -- 10,440,442(-) CAGAA(C/T)GGGCC utr-variant-3-prime
rs1049500 -- 10,440,841(-) AACCC(C/T)GACTT reference, synonymous-codon
rs1405948 -- 10,443,034(-) TTTCC(C/T)AGAAG intron-variant
rs1804032 -- 10,441,631(-) CTGCC(C/T)GAAAT synonymous-codon, reference
rs2302613 -- 10,445,176(+) TGGAA(C/T)TGAAA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ODC1 Gene

Variant ID Type Subtype PubMed ID
dgv4051n71 CNV Loss 21882294
dgv4052n71 CNV Loss 21882294
nsv873647 CNV Loss 21882294
dgv4053n71 CNV Loss 21882294
nsv873649 CNV Loss 21882294
esv23515 CNV Loss 19812545

Variation tolerance for ODC1 Gene

Residual Variation Intolerance Score: 6.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ODC1 Gene

HapMap Linkage Disequilibrium report
ODC1
Human Gene Mutation Database (HGMD)
ODC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODC1 Gene

Disorders for ODC1 Gene

MalaCards: The human disease database

(19) MalaCards diseases for ODC1 Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
cerebral artery occlusion
transient cerebral ischemia
  • transient cerebral ischaemia nos
sleeping sickness
  • african sleeping sickness
kidney hypertrophy
  • hypertrophy of kidney
mesenteric vascular occlusion
- elite association
Search ODC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ODC1

Genetic Association Database (GAD)
ODC1
Human Genome Epidemiology (HuGE) Navigator
ODC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ODC1
genes like me logo Genes that share disorders with ODC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ODC1 Gene

Publications for ODC1 Gene

  1. Polyamine metabolism in brain tumours: diagnostic relevance of quantitative biochemistry. (PMID: 11413269) Ernestus R.I. … Klug N. (J. Neurol. Neurosurg. Psychiatr. 2001) 23 25 26 67
  2. Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397. (PMID: 12627959) Jackson L.K. … Phillips M.A. (Biochemistry 2003) 23 25 67
  3. A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer. (PMID: 20051371) Bailey H.H. … Carbone P.P. (Cancer Prev Res (Phila) 2010) 23 67
  4. eIF5A promotes translation elongation, polysome disassembly and stress granule assembly. (PMID: 20376341) Li C.H. … Anderson P. (PLoS ONE 2010) 23 67
  5. Lactobacillus rhamnosus GG influences polyamine metabolism in HGC-27 gastric cancer cell line: a strategy toward nutritional approach to chemoprevention of gastric cance. (PMID: 20388096) Linsalata M. … Russo F. (Curr. Pharm. Des. 2010) 23 67

Products for ODC1 Gene

Sources for ODC1 Gene

Back to Top

Content