Aliases for ODC1 Gene
External Ids for ODC1 Gene
Previous GeneCards Identifiers for ODC1 Gene
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
GeneCards Summary for ODC1 Gene
ODC1 (Ornithine Decarboxylase 1) is a Protein Coding gene. Diseases associated with ODC1 include Colorectal Cancer and Sleeping Sickness. Among its related pathways are Urea cycle and metabolism of amino groups and Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include protein homodimerization activity and ornithine decarboxylase activity. An important paralog of this gene is AZIN2.
UniProtKB/Swiss-Prot for ODC1 Gene
Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.