External Ids for ODC1 Gene
Previous GeneCards Identifiers for ODC1 Gene
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
GeneCards Summary for ODC1 Gene
ODC1 (Ornithine Decarboxylase 1) is a Protein Coding gene. Diseases associated with ODC1 include colorectal cancer and sleeping sickness. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include protein homodimerization activity and ornithine decarboxylase activity. An important paralog of this gene is AZIN2.
UniProtKB/Swiss-Prot for ODC1 Gene
Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.