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ODC1 Gene

protein-coding GIFtS: 72

GC02M010497

ornithine decarboxylase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 4.1.1.17 ^³
ODC ^¹, ², ³

Descriptions
ornithine decarboxylase 1 ^²

External Ids
HGNC: 8109¹
Entrez Gene: 4953²
UniProtKB: P11926³
Ensembl: ENSG00000115758⁷

Search outside databases for aliases for ODC1 gene

Previous GC identifers: GC02M010365 GC02M010631 GC02M010602 GC02M010531

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ODC1:

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes

ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting

stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally

localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be

located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq]

Gene Wiki entry for ODC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ODC1 gene

Entrez Gene cytogenetic band: 2p25 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25

ODC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M010497: (about GC identifiers)

Start:	10,497,959 bp from pter
End:	10,505,904 bp from pter
Size:	7,946 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005334.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926 (See protein sequence)

Recommended Name: Ornithine decarboxylase

Size: 461 amino acids; 51148 Da

Cofactor: Pyridoxal phosphate

Subunit: Homodimer

PDB structures from and Proteopedia :

1D7K (3D)

2ON3 (3D)

2OO0 (3D)

Secondary accessions: Q6LDS9

Post-translational modifications:

S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002530.1

ENSEMBL proteins:

ENSP00000385333 ENSP00000234111

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Ornithine Decarboxylase)
	Human Recombinant Proteins from Abnova (ODC1)

OriGene Purified Recombinant Human Protein: ODC1

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IDA	18029348
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0005829	cytosol	IEA	--

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Antibodies for ODC1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for ODC1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Ornithine Decarboxylase), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for ODC1

Assays for ODC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11926

ProtoNet protein and cluster: P11926

2 Blocks protein families:

IPB000183 Orn/DAP/Arg decarboxylase

IPB002433 Ornithine decarboxylase signature

UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ODC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ODC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002539

Applied Biosystems Silencer® siRNAs for ODC1

Sigma-Aldrich siRNA and siRNA Panels for ODC1

Sigma-Aldrich shRNA for ODC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ODC1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002539
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002539
untagged cDNA clone in CMV expression vector: NM_002539

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002539

UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926

Catalytic activity: L-ornithine = putrescine + CO(2)

Enzyme regulation: Inhibited by S-nitrosylation

Enzyme Number (IUBMB): EC 4.1.1.17

Genatlas biochemistry entry for ODC1:

ornithine decarboxylase 1,ornithine metabolism,mitochondrial matrix

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Odc1):

embryogenesis

lethality-prenatal/perinatal

normal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004586	ornithine decarboxylase activity	TAS	2317811
GO:0005515	protein binding	IPI	17353931
GO:0016829	lyase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for ODC1 (Your Favorite Gene powered by Ingenuity)

Arginine and Proline Metabolism
Polyamine Regulation in Colon Cancer
Urea Cycle and Metabolism of Amino Groups

GeneDecks ODC1 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: DCOR_HUMAN, P11926

Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway;

putrescine from L-ornithine: step 1/1

Gene Network Central^TM Interacting Genes and Proteins Network for ODC1

5/92 Interacting proteins for ODC1 (P11926^{1, 2} ENSP00000234111³) via UniProtKB, MINT, and/or STRING (see all 92 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OAZ2	O95190¹, ENSP00000316264³	EBI-1044287, EBI-1051861 STRING (score=.996)
SMAD3	P84022²	MINT-51238
OAZ1	ENSP00000314813³	STRING (score=.996)
SRM	ENSP00000366156³	STRING (score=.995)
SLC25A21	ENSP00000329452³	STRING (score=.992)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001822	kidney development	IEA	--
GO:0006596	polyamine biosynthetic process	NAS	--
GO:0008284	positive regulation of cell proliferation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ODC1:

Inhibitor

Compounds for ODC1 available from Tocris Bioscience

Compound	Action	CAS number
DFMO	Ornithine decarboxylase inhibitor	[70052-12-9]

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10/57 Novoseek chemical compound relationships for ODC1 gene (see all 57 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ornithine	98.85	2767	11461922 (8), 8719885 (8), 1872891 (7), 8354283 (7) (see all 99)
putrescine	94.76	268	1952937 (6), 8719885 (6), 2146783 (5), 1545142 (5) (see all 99)
spermidine	94.04	233	1872863 (4), 2241982 (4), 8486633 (4), 11123206 (3) (see all 99)
spermine	92.48	182	2127337 (5), 2344358 (5), 11123206 (4), 1573975 (3) (see all 99)
s-adenosylmethionine	83.20	125	7954423 (3), 2314049 (2), 1930914 (2), 1499693 (2) (see all 81)
1-aminooxy-3-aminopropane	80.99	9	17407445 (2), 8462122 (1), 11163334 (1), 7896733 (1)
n(1),n(8)-bis(ethyl)spermidine	74.96	2	2344358 (1)
etarotene	74.96	2	7619051 (1), 8912706 (1)
1,12-dimethylspermine	74.96	2	7980394 (1), 7559809 (1)
n1-acetylspermidine	74.51	1	12355213 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ODC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ODC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002539

Sigma-Aldrich siRNA and siRNA Panels for ODC1

Sigma-Aldrich shRNA for ODC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002539

REFSEQ mRNAs for ODC1 gene:

NM_002539.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002539

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002539
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002539
                                 untagged cDNA clone in CMV expression vector: NM_002539

Additional cDNA sequence:

AK292352.1 AK301956.1 AK312766.1 BC014562.2 BC025296.1 CR613073.1 CR614398.1 CR615738.1

CR621233.1 D28365.1 DQ185043.1 M16650.2 M20372.1 X55362.1

24/37 DOTS entries (see all 37 ):

DT.40254377 DT.100669014 DT.95110200 DT.100880136 DT.120936261 DT.40125078 DT.120936299 DT.100762913

DT.85104235 DT.92462214 DT.92462225 DT.100659486 DT.91889719 DT.92462212 DT.95197533 DT.100039111

DT.100880128 DT.95197532 DT.100705807 DT.100771956 DT.100880124 DT.100880142 DT.120936269 DT.120936276

24/834 AceView cDNA sequences (see all 834 ):

CF139713 BU930985 CR613073 BU172996 BQ064242 BP334819 BQ721981 BU553582

BG681261 BE728546 BI091808 BE298146 BM699693 CF121301 CF131851 BQ014883

AW410398 BQ424534 BU181149 BE765858 AU118013 BQ420616 BE740308 BU191253

highest scoring ESTs for ODC1:

AL514594 AL516341 AL526997 AL538746 AL551848 AL552012 AU119926 AW328091 AW410397 BC014562

Unigene Cluster for ODC1:

Ornithine decarboxylase 1

Hs.467701 [show with all ESTs]

Unigene Representative Sequence: CR614398

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ODC1 (see all 14 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·
SP1:													-		-		-		-																														-		-
SP2:					-		-		-		-		-		-		-		-
SP3:									-		-		-		-		-		-
SP4:																	-		-
SP5:													-		-		-		-		-		-

ExUns:	15b	^	16	^	17a	·	17b	^	18
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ODC1

2 Ensembl transcripts including schematic representations:

ENST00000405333 ENST00000234111

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ODC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ODC1

¹ / ² / ³

4 probe-sets matching ODC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36203_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.97	X16277	0.20	1.00	0.72	1
1081_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.03	M33764	0.20	1.00	0.72	1
200790_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002539	0.60	1.00	0.82	1
200790_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATGCAGCCAT

SOURCE GeneReport for Unigene cluster: Hs.467701
Expression variation in blood from EXPOLDB for ODC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ODC1 gene from 5/21 species (see all 21 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ODC1¹	--	ornithine decarboxylase 1	88.94(n) 95.23(a)	475666 XM_851502.1 XP_856595.1
chimpanzee (Pan troglodytes)	ODC1¹	--	ornithine decarboxylase 1	99.49(n) 99.35(a)	459027 XM_001156939.1 XP_001156939.1
cow (Bos taurus)	ODC1¹	--	ornithine decarboxylase 1	89.01(n) 93.49(a)	281365 NM_174130.2 NP_776555.1
rat (Rattus norvegicus)	Odc1¹	--	ornithine decarboxylase 1	86.55(n) 91.54(a)	24609 NM_012615.1 NP_036747.1
mouse (Mus musculus)	Odc1^{1, 5}	12 (6.00 cM)⁵	ornithine decarboxylase, structural 1^{1, 5}	86.62(n)¹ 90.67(a)¹	18263¹ NM_013614.2¹ NP_038642.2¹ AI848698⁵ AK077679⁵ (see all 46)

About this table Species with no ortholog for ODC1

ENSEMBL Gene Tree for ODC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ODC1 gene

ADC² AZIN1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/107 NCBI SNPs in ODC1 are shown (see all 107 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 85)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2009741^1,2	A,C,F	10507840(-)	`CAGGCC/TCTCTG`	1	--	ng3¹		9	MN EA NS	2048
	rs7609174^1,2	C,F	10507831(+)	`GCCTCC/TAGGCA`	1	--	ng3¹		5	NS	186
	rs6738288^1,2	C,F	10502615(+)	`GATTTC/TTTGAT`	1	--	ut5¹		5	NS	190
--	rs28742580^1,2	C,F	10506003(-)	`CCGGCC/GGTGTC`	1	--	ng3¹ ese³		5	NS	180
	rs2302614^1,2	C,F	10502762(+)	`AAGAAA/CTATTT`	1	--	ut5¹		5	NS	190
--	rs2302613^1,2	C,F	10502753(+)	`TGGAAT/CTGAAA`	1	--	ut5¹		5	NS	190
--	rs16856239^1,2	C,F	10497910(+)	`CTATAC/TGGGAT`	1	--	ng5¹ ese³		8	NA NS	328
--	rs11538365^1,2	C,F	10502754(-)	`CTTTCA/GATTCC`	1	--	ut5¹		5	NS	190
	rs28364601^1,2	C,F	10502815(-)	`GCACAC/TGCAGA`	1	--	ut5¹ ese³		7	NS MN EA	1442
	rs28362422^1,2	F	10497472(-)	`GTGTAC/TCCCCG`	1	--	ng5¹		5	NS	190

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HapMap Linkage Disequilibrium images for ODC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 165640 disorders: 114500

10/94 Novoseek disease relationships for ODC1 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colon cancer	55.32	38	11163334 (3), 7705952 (2), 18062235 (2), 15818733 (2) (see all 19)
tumors	53.56	330	1951878 (6), 2317797 (6), 9293942 (5), 17582600 (5) (see all 99)
ehrlich ascites tumor	53.08	12	1847813 (3), 7647340 (1), 2384152 (1), 2115438 (1) (see all 6)
colon adenocarcinoma	52.75	14	2317797 (2), 10816435 (1), 2113770 (1), 15716048 (1) (see all 7)
colon tumor	52.58	16	15918191 (5), 2009526 (3), 10395625 (1), 1598217 (1) (see all 7)
sleeping sickness	52.10	10	7598507 (1), 8347171 (1), 17504214 (1), 17610127 (1) (see all 6)
colon carcinoma	49.86	11	1997467 (1), 1324153 (1), 8444085 (1), 9293942 (1) (see all 8)
cancer	49.19	119	18339422 (3), 1423312 (3), 8348060 (3), 17957960 (3) (see all 57)
skin tumor	48.26	6	12201673 (1), 8640756 (1), 10874208 (1), 12757023 (1) (see all 5)
premalignant	46.46	9	9232343 (1), 11564951 (1), 16003136 (1), 8428179 (1) (see all 7)

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1 PharmGKB disease relationship for ODC1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Human Gene Mutation Database: ODC1
Genetic Association Database: ODC1
Human Genome Epidemiology Navigator: ODC1 (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/879 PubMed articles for ODC1 gene (see all 879 ):

Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. (PubMed id 10623504)^{1, 3, 4} Almrud J.J....Hackert M.L. (2000)
Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. (PubMed id 11461922)^{1, 3, 4} Bauer P.M....Ignarro L.J. (2001)
Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells. (PubMed id 2317811)^{1, 3, 4} Hsieh J.T.... Verma A.K. (1990)
Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element. (PubMed id 8519686)^{1, 3, 4} Wright P.S.... Flanagan M.A. (1995)
Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. (PubMed id 12810952)^{1, 3, 6} Martinez M.E....Gerner E.W. (2003)
Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells. (PubMed id 1598217)^{1, 3, 4} Moshier J.A.... Flanagan M.A. (1992)
Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene. (PubMed id 2227439)^{1, 3, 4} Hickok N.J.... Jaenne O.A. (1990)
Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population. (PubMed id 15734972)^{3, 6} You W.C....Gail M.H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Isolation and expression of a human ornithine decarboxylase gene. (PubMed id 2318872)^{3, 4} Moshier J.A....Luk G.D. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4953	HGNC: 8109	AceView: ODC1	Ensembl:ENSG00000115758	euGenes: HUgn4953
ECgene: ODC1	H-InvDB: ODC1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ODC1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/odc1/
Wikipedia	http://en.wikipedia.org/wiki/Ornithine_decarboxylase

Licensable Technologies for ODC1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ODC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
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Antibodies for ODC1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ODC1 Gene at Home site.
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ODC1 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for ODC1

Summaries
for ODC1

Genomic Location
for ODC1

Proteins
for ODC1

Protein Domains/
Families
for ODC1

Gene Function
for ODC1

Pathways & Interactions
for ODC1

Drugs & Compounds
for ODC1

Transcripts
for ODC1

Expression
for ODC1

Orthologs
for ODC1

Paralogs
for ODC1

SNPs/Variants
for ODC1

Disorders & Mutations
for ODC1

Medical News
for ODC1

Publications
for ODC1

Search for ODC1

Genome Databases showing ODC1

Other Databases showing ODC1

Specialized Databases showing ODC1

Licensable Technologies
for ODC1

Services
for ODC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ODC1 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor ODC1

Summariesfor ODC1

Genomic Locationfor ODC1

Proteinsfor ODC1

Protein Domains/Familiesfor ODC1

Gene Functionfor ODC1

Pathways & Interactionsfor ODC1

Drugs & Compoundsfor ODC1

Transcriptsfor ODC1

Expression for ODC1

Orthologsfor ODC1

Paralogsfor ODC1

SNPs/Variantsfor ODC1

Disorders & Mutationsfor ODC1

Medical Newsfor ODC1

Publicationsfor ODC1

Search for ODC1

Genome Databases showing ODC1

Other Databases showing ODC1

Specialized Databases showing ODC1

Licensable Technologiesfor ODC1

Servicesfor ODC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ODC1

Summaries
for ODC1

Genomic Location
for ODC1

Proteins
for ODC1

Protein Domains/
Families
for ODC1

Gene Function
for ODC1

Pathways & Interactions
for ODC1

Drugs & Compounds
for ODC1

Transcripts
for ODC1

Expression
for ODC1

Orthologs
for ODC1

Paralogs
for ODC1

SNPs/Variants
for ODC1

Disorders & Mutations
for ODC1

Medical News
for ODC1

Publications
for ODC1

Licensable Technologies
for ODC1

Services
for ODC1