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Aliases for ODAM Gene

Aliases for ODAM Gene

  • Odontogenic, Ameloblast Asssociated 2 3 5
  • APIN 3 4
  • Odontogenic Ameloblast-Associated Protein 3

External Ids for ODAM Gene

Previous GeneCards Identifiers for ODAM Gene

  • GC04P071098
  • GC04P066865
  • GC04P071062

Summaries for ODAM Gene

GeneCards Summary for ODAM Gene

ODAM (Odontogenic, Ameloblast Asssociated) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

UniProtKB/Swiss-Prot for ODAM Gene

  • Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

Gene Wiki entry for ODAM Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODAM Gene

Genomics for ODAM Gene

Regulatory Elements for ODAM Gene

Enhancers for ODAM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F070197 0.7 ENCODE 0.8 +2.3 2325 0.5 GATAD2A NFIA TEAD1 CEBPB TEAD3 GATA3 SSRP1 ZNF652 ZBTB26 RXRB ODAM FDCSP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ODAM on UCSC Golden Path with GeneCards custom track

Genomic Location for ODAM Gene

Chromosome:
4
Start:
70,195,726 bp from pter
End:
70,204,576 bp from pter
Size:
8,851 bases
Orientation:
Plus strand

Genomic View for ODAM Gene

Genes around ODAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODAM Gene

Proteins for ODAM Gene

  • Protein details for ODAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1E959-ODAM_HUMAN
    Recommended name:
    Odontogenic ameloblast-associated protein
    Protein Accession:
    A1E959
    Secondary Accessions:
    • Q8WWE5
    • Q9NWZ9

    Protein attributes for ODAM Gene

    Size:
    279 amino acids
    Molecular mass:
    30777 Da
    Quaternary structure:
    • Interacts (via C-terminus) with ARHGEF5.
    Miscellaneous:
    • ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits.
    SequenceCaution:
    • Sequence=BAA91226.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ODAM Gene

Post-translational modifications for ODAM Gene

  • O-glycosylated.
  • Glycosylation at Thr 115, Thr 119, Thr 244, Ser 249, Thr 250, Thr 251, Thr 255, Ser 256, Thr 261, Thr 263, Thr 273, and Ser 275
  • Modification sites at PhosphoSitePlus

Other Protein References for ODAM Gene

No data available for DME Specific Peptides for ODAM Gene

Domains & Families for ODAM Gene

Protein Domains for ODAM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ODAM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1E959

UniProtKB/Swiss-Prot:

ODAM_HUMAN :
  • Belongs to the ODAM family.
Family:
  • Belongs to the ODAM family.
genes like me logo Genes that share domains with ODAM: view

No data available for Gene Families for ODAM Gene

Function for ODAM Gene

Molecular function for ODAM Gene

UniProtKB/Swiss-Prot Function:
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

Gene Ontology (GO) - Molecular Function for ODAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25911094
genes like me logo Genes that share ontologies with ODAM: view
genes like me logo Genes that share phenotypes with ODAM: view

Animal Model Products

miRNA for ODAM Gene

miRTarBase miRNAs that target ODAM

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODAM Gene

Localization for ODAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODAM Gene

Secreted. Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODAM gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ODAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 25911094
GO:0005634 nucleus IDA 25911094
GO:0005737 cytoplasm IDA 25911094
GO:0043205 fibril IDA --
genes like me logo Genes that share ontologies with ODAM: view

Pathways & Interactions for ODAM Gene

genes like me logo Genes that share pathways with ODAM: view

Pathways by source for ODAM Gene

2 Reactome pathways for ODAM Gene

Gene Ontology (GO) - Biological Process for ODAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 25911094
GO:0006954 inflammatory response IDA 25911094
GO:0009611 response to wounding IEA --
GO:0010628 positive regulation of gene expression IMP 25911094
GO:0031214 biomineral tissue development IEA --
genes like me logo Genes that share ontologies with ODAM: view

No data available for SIGNOR curated interactions for ODAM Gene

Transcripts for ODAM Gene

Unigene Clusters for ODAM Gene

Odontogenic, ameloblast asssociated:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODAM Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for ODAM Gene

GeneLoc Exon Structure for
ODAM
ECgene alternative splicing isoforms for
ODAM

Expression for ODAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ODAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ODAM Gene

This gene is overexpressed in Minor Salivary Gland (x50.6).

Protein differential expression in normal tissues from HIPED for ODAM Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ODAM Gene



Protein tissue co-expression partners for ODAM Gene

NURSA nuclear receptor signaling pathways regulating expression of ODAM Gene:

ODAM

SOURCE GeneReport for Unigene cluster for ODAM Gene:

Hs.143811

mRNA Expression by UniProt/SwissProt for ODAM Gene:

A1E959-ODAM_HUMAN
Tissue specificity: Expressed in the junctional epithelium of healthy teeth. In periodontitis, absent in the pocket epithelium of the diseased periodontium but is detected in the gingival crevicular fluid.
genes like me logo Genes that share expression patterns with ODAM: view

Primer Products

Orthologs for ODAM Gene

This gene was present in the common ancestor of mammals.

Orthologs for ODAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODAM 34 35
  • 98.33 (n)
dog
(Canis familiaris)
Mammalia ODAM 34 35
  • 82.49 (n)
cow
(Bos Taurus)
Mammalia ODAM 34 35
  • 82.31 (n)
mouse
(Mus musculus)
Mammalia Odam 34 16 35
  • 75.95 (n)
rat
(Rattus norvegicus)
Mammalia Odam 34
  • 75.33 (n)
oppossum
(Monodelphis domestica)
Mammalia ODAM 35
  • 43 (a)
OneToOne
Species where no ortholog for ODAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ODAM Gene

ENSEMBL:
Gene Tree for ODAM (if available)
TreeFam:
Gene Tree for ODAM (if available)

Paralogs for ODAM Gene

No data available for Paralogs for ODAM Gene

Variants for ODAM Gene

Sequence variations from dbSNP and Humsavar for ODAM Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_039813 A colorectal cancer sample
rs10050001 -- 70,198,850(+) CTGAA(C/T)TTCCA intron-variant
rs10518073 -- 70,199,191(-) GATTA(C/T)ACTAG intron-variant
rs112027876 -- 70,204,695(+) GACAC(-/A)AGTCA downstream-variant-500B
rs112509037 -- 70,202,988(+) TAGTG(C/T)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ODAM Gene

Variant ID Type Subtype PubMed ID
dgv5319n100 CNV loss 25217958
dgv9126n54 CNV loss 21841781
esv2760880 CNV loss 21179565
esv3600930 CNV loss 21293372
nsv1012495 CNV gain 25217958
nsv517703 CNV loss 19592680
nsv829963 CNV gain 17160897
nsv998828 CNV gain 25217958

Variation tolerance for ODAM Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.59; 82.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ODAM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ODAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODAM Gene

Disorders for ODAM Gene

Relevant External Links for ODAM

Genetic Association Database (GAD)
ODAM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ODAM

No disorders were found for ODAM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ODAM Gene

Publications for ODAM Gene

  1. Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein. (PMID: 14647039) Solomon A. … Westermark P. (J. Lab. Clin. Med. 2003) 2 3 4 22 64
  2. Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. (PMID: 25911094) Lee H.K. … Park J.C. (J. Biol. Chem. 2015) 3 4 64
  3. Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia. (PMID: 17647262) Moffatt P. … Nanci A. (J. Cell. Biochem. 2008) 3 4 64
  4. Identification of secreted and membrane proteins in the rat incisor enamel organ using a signal-trap screening approach. (PMID: 16674676) Moffatt P. … Nanci A. (Eur. J. Oral Sci. 2006) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ODAM Gene

Sources for ODAM Gene

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