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Aliases for ODAM Gene

Aliases for ODAM Gene

  • Odontogenic, Ameloblast Asssociated 2 3
  • APIN 3 4 6
  • Odontogenic Ameloblast-Associated Protein 3

External Ids for ODAM Gene

Previous GeneCards Identifiers for ODAM Gene

  • GC04P071098
  • GC04P066865
  • GC04P071062

Summaries for ODAM Gene

GeneCards Summary for ODAM Gene

ODAM (Odontogenic, Ameloblast Asssociated) is a Protein Coding gene. Diseases associated with ODAM include calcifying epithelial odontogenic tumor and ossifying fibroma. Among its related pathways are Disease and RNA Polymerase I Promoter Opening.

UniProtKB/Swiss-Prot for ODAM Gene

  • Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process

Gene Wiki entry for ODAM Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODAM Gene

Genomics for ODAM Gene

Regulatory Elements for ODAM Gene

Genomic Location for ODAM Gene

Start:
70,195,724 bp from pter
End:
70,204,576 bp from pter
Size:
8,853 bases
Orientation:
Plus strand

Genomic View for ODAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ODAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODAM Gene

Proteins for ODAM Gene

  • Protein details for ODAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1E959-ODAM_HUMAN
    Recommended name:
    Odontogenic ameloblast-associated protein
    Protein Accession:
    A1E959
    Secondary Accessions:
    • Q8WWE5
    • Q9NWZ9

    Protein attributes for ODAM Gene

    Size:
    279 amino acids
    Molecular mass:
    30777 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits
    SequenceCaution:
    • Sequence=BAA91226.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ODAM Gene

Proteomics data for ODAM Gene at MOPED

Post-translational modifications for ODAM Gene

  • O-glycosylated.
  • Glycosylation at Thr115, Thr119, Thr244, Ser249, Thr250, Thr251, Thr255, Ser256, Thr261, Thr263, Thr273, and Ser275
  • Modification sites at PhosphoSitePlus

Other Protein References for ODAM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ODAM Gene

Domains for ODAM Gene

Protein Domains for ODAM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ODAM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1E959

UniProtKB/Swiss-Prot:

ODAM_HUMAN :
  • A1E959
Family:
  • Belongs to the ODAM family.
genes like me logo Genes that share domains with ODAM: view

No data available for Gene Families for ODAM Gene

Function for ODAM Gene

Molecular function for ODAM Gene

UniProtKB/Swiss-Prot Function: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process

Phenotypes for ODAM Gene

GenomeRNAi human phenotypes for ODAM:
genes like me logo Genes that share phenotypes with ODAM: view

Animal Model Products

CRISPR Products

miRNA for ODAM Gene

miRTarBase miRNAs that target ODAM

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ODAM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for ODAM Gene

Localization for ODAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODAM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ODAM Gene COMPARTMENTS Subcellular localization image for ODAM gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ODAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0043205 fibril IDA 14647039
genes like me logo Genes that share ontologies with ODAM: view

Pathways for ODAM Gene

SuperPathways for ODAM Gene

Superpath Contained pathways
1 Disease
2 RNA Polymerase I Promoter Opening
.68
genes like me logo Genes that share pathways with ODAM: view

Pathways by source for ODAM Gene

2 Reactome pathways for ODAM Gene

Gene Ontology (GO) - Biological Process for ODAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031214 biomineral tissue development IEA --
GO:0042475 odontogenesis of dentin-containing tooth IEP 16674676
genes like me logo Genes that share ontologies with ODAM: view

Transcripts for ODAM Gene

Unigene Clusters for ODAM Gene

Odontogenic, ameloblast asssociated:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ODAM

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODAM Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for ODAM Gene

GeneLoc Exon Structure for
ODAM
ECgene alternative splicing isoforms for
ODAM

Expression for ODAM Gene

mRNA expression in normal human tissues for ODAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ODAM Gene

This gene is overexpressed in Minor Salivary Gland (50.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ODAM Gene

SOURCE GeneReport for Unigene cluster for ODAM Gene Hs.143811

genes like me logo Genes that share expressions with ODAM: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ODAM Gene

Orthologs for ODAM Gene

This gene was present in the common ancestor of mammals.

Orthologs for ODAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODAM 35
  • 98.33 (n)
  • 96.77 (a)
ODAM 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ODAM 35
  • 82.31 (n)
  • 72.2 (a)
ODAM 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ODAM 35
  • 82.49 (n)
  • 75.54 (a)
ODAM 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Odam 35
  • 75.95 (n)
  • 67.77 (a)
Odam 16
Odam 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ODAM 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Odam 35
  • 75.33 (n)
  • 65.7 (a)
Species with no ortholog for ODAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ODAM Gene

ENSEMBL:
Gene Tree for ODAM (if available)
TreeFam:
Gene Tree for ODAM (if available)

Paralogs for ODAM Gene

No data available for Paralogs for ODAM Gene

Variants for ODAM Gene

Sequence variations from dbSNP and Humsavar for ODAM Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs966303 -- 70,196,358(-) AACTC(G/T)TTATT upstream-variant-2KB, intron-variant
rs1383436 -- 70,196,125(-) TCTAT(A/G)TTGAA upstream-variant-2KB, intron-variant
rs1399244 -- 70,199,639(+) TTACA(A/G)ACGTC intron-variant
rs1514391 -- 70,197,625(+) GTTGG(C/T)AGGTT intron-variant
rs1514392 -- 70,197,626(+) TTGGC(A/G)GGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ODAM Gene

Variant ID Type Subtype PubMed ID
nsv517703 CNV Loss 19592680
nsv829963 CNV Gain 17160897
nsv879466 CNV Loss 21882294

Relevant External Links for ODAM Gene

HapMap Linkage Disequilibrium report
ODAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODAM Gene

Disorders for ODAM Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ODAM Gene including...

Search for ODAM Gene in MalaCards »

(1) University of Copenhagen DISEASES for ODAM Gene

Relevant External Links for ODAM

Genetic Association Database (GAD)
ODAM
genes like me logo Genes that share disorders with ODAM: view

No data available for UniProtKB/Swiss-Prot for ODAM Gene

Publications for ODAM Gene

  1. Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein. (PMID: 14647039) Solomon A. … Westermark P. (J. Lab. Clin. Med. 2003) 2 3 4 23
  2. Identification of secreted and membrane proteins in the rat incisor enamel organ using a signal-trap screening approach. (PMID: 16674676) Moffatt P. … Nanci A. (Eur. J. Oral Sci. 2006) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia. (PMID: 17647262) Moffatt P. … Nanci A. (J. Cell. Biochem. 2008) 3 4
  5. Expression of odontogenic ameloblast-associated protein (ODAM) in dental and other epithelial neoplasms. (PMID: 18472969) Kestler D.P. … Solomon A. (Mol. Med. 2008) 3

Products for ODAM Gene

Sources for ODAM Gene

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