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ODAM Gene

protein-coding   GIFtS: 53
GCID: GC04P071062

Odontogenic, Ameloblast Asssociated

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Odontogenic, Ameloblast Asssociated1 2
APIN2 3 5
Odontogenic Ameloblast-Associated Protein2
Apin3

External Ids:    HGNC: 260431   Entrez Gene: 549592   Ensembl: ENSG000001092057   OMIM: 6148435   UniProtKB: A1E9593   

Export aliases for ODAM gene to outside databases

Previous GC identifers: GC04P071098 GC04P066865


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ODAM Gene:
ODAM (odontogenic, ameloblast asssociated) is a protein-coding gene. Diseases associated with ODAM include calcifying epithelial odontogenic tumor, and dental enamel hypoplasia.

UniProtKB/Swiss-Prot: ODAM_HUMAN, A1E959
Function: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that
results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of
mineralization process

Gene Wiki entry for ODAM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ODAM gene promoter:
         C/EBPbeta   CBF-C   POU2F1   CBF-A   CBF-B   POU2F1a   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidODAM promoter sequence
   Search Chromatin IP Primers for ODAM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ODAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

ODAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ODAM gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P071062:  view genomic region     (about GC identifiers)

Start:
71,062,213 bp from pter      End:
71,070,293 bp from pter
Size:
8,081 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ODAM_HUMAN, A1E959 (See protein sequence)
Recommended Name: Odontogenic ameloblast-associated protein precursor  
Size: 279 amino acids; 30777 Da
Miscellaneous: ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also
known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the
mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of
squamous-cell proliferation, calcification, and, notably, amyloid deposits
Sequence caution: Sequence=BAA91226.1; Type=Erroneous initiation;
Secondary accessions: Q8WWE5 Q9NWZ9

Explore the universe of human proteins at neXtProt for ODAM: NX_A1E959

Post-translational modifications: 

  • O-glycosylated (By similarity)1
  • Glycosylation2 at Thr115, Thr119, Thr244, Ser249, Thr250, Thr251, Thr255, Ser256, Thr261, Thr263,
                                 Thr273, Ser275
  • REFSEQ proteins: NP_060325.3  
    ENSEMBL proteins: 
     ENSP00000379401   ENSP00000423070   ENSP00000426106   ENSP00000422100  
    Reactome Protein details: A1E959

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026802 Odam

    Graphical View of Domain Structure for InterPro Entry A1E959

    ProtoNet protein and cluster: A1E959

    UniProtKB/Swiss-Prot: ODAM_HUMAN, A1E959
    Similarity: Belongs to the ODAM family


    ODAM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ODAM_HUMAN, A1E959
    Function: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that
    results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of
    mineralization process

    Phenotypes:
         1 GenomeRNAi human phenotype for ODAM:

     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ODAM
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ODAM
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    miRNA
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    miRTarBase miRNAs that target ODAM:
    hsa-mir-26b-5p (MIRT029400)

    Block miRNA regulation of human, mouse, rat ODAM using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ODAM:
    hsa-miR-3915
    SwitchGear 3'UTR luciferase reporter plasmidODAM 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ODAM

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODAM

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ODAM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ODAM_HUMAN, A1E959: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0043205fibril IDA14647039

    ODAM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ODAM About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    Amyloids0.68
    2Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ODAM
        Amyloids



    ODAM for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ODAM
    Interactions:

        Search GeneGlobe Interaction Network for ODAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for ODAM (A1E9593 ENSP000003794014) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    TOLLIPQ9H0E23I2D: score=2 
    APPENSP000002849814STRING: ENSP00000284981
    NPPAENSP000003656634STRING: ENSP00000365663
    PRLENSP000003021504STRING: ENSP00000302150
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031214biomineral tissue development IEA--
    GO:0042475odontogenesis of dentin-containing tooth IEP16674676

    ODAM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ODAM



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ODAM gene: 
    NM_017855.3  

    Unigene Cluster for ODAM:

    Odontogenic, ameloblast asssociated
    Hs.143811  [show with all ESTs]
    Unigene Representative Sequence: NM_017855
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396094(uc003hfc.3) ENST00000510709 ENST00000506248 ENST00000514097
    ENST00000510847
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ODAM using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ODAM:
    hsa-miR-3915
    SwitchGear 3'UTR luciferase reporter plasmidODAM 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ODAM
    Predesigned siRNA for gene silencing in human, mouse, rat ODAM
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ODAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ODAM
    Primer
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    OriGene qPCR primer pairs and template standards for ODAM
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ODAM
      QuantiTect SYBR Green Assays in human, mouse, rat ODAM
      QuantiFast Probe-based Assays in human, mouse, rat ODAM

    Additional mRNA sequence: 

    AK000520.1 AK098169.1 AK225547.1 BC017796.1 EF113908.1 

    5 DOTS entries:

    DT.99935634  DT.91741889  DT.435385  DT.121249300  DT.121249513 

    Selected AceView cDNA sequences (see all 29):

    AA729875 CD723278 BC017796 AK098169 CD724162 BX487613 BX101316 NM_017855 
    CD723326 AI697049 BG194365 BV205854 AA025290 AK000520 AI185064 BV205862 
    BG205136 BG218440 AA025291 BG188111 BG536438 AA024396 AA385519 BG198398 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ODAM    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -                                       
    SP2:                                                                              
    SP3:                                      -                                       
    SP4:                                      -           -                           


    ECgene alternative splicing isoforms for ODAM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ODAM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATATGTA
    ODAM Expression
    About this image


    ODAM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Arteries
     
     Heart (Cardiovascular System)
    ODAM Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.143811
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ODAM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ODAM gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Odam1 , 5 odontogenic, ameloblast asssociated1, 5 75.95(n)1
    67.77(a)1
      5 (43.56 cM)5
    695921  NM_027128.21  NP_081404.21 
     878850295 


    ENSEMBL Gene Tree for ODAM (if available)
    TreeFam Gene Tree for ODAM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ODAM (see all 254)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0398134
    A colorectal cancer sample4--see VAR_0398132 E D mis40--------
    rs1165152121,2
    C,F--71060270(+) CTAAAC/TGTAAT 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1895814221,2
    --71060288(+) AATACC/TTTCTA 1 -- us2k10--------
    rs1810912521,2
    --71060310(+) GTCCTA/GCTGGT 1 -- us2k10--------
    rs728565621,2
    C,F--71060317(+) TGGTGG/TGTTTT 1 -- us2k14Minor allele frequency- T:0.09WA CSA NA 242
    rs1160863191,2
    F--71060325(+) TTTCTT/GCTTTA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1859214101,2
    --71060362(+) ACTAAC/TGATTT 1 -- us2k10--------
    rs1890642981,2
    --71060385(+) TTTTTC/GACCAG 1 -- us2k10--------
    rs356413071,2
    C,F--71060469(+) CAAATT/GTATTA 1 -- us2k19Minor allele frequency- G:0.36NA WA CSA EA 369
    rs1814546951,2
    --71060589(+) AACACC/TTGTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ODAM (71062213 - 71070293 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ODAM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv879466CNV Loss21882294
    nsv517703CNV Loss19592680
    nsv829963CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ODAM
    DNA2.0 Custom Variant and Variant Library Synthesis for ODAM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614843    OMIM disorders: --

    7 diseases for ODAM:    
    About MalaCards
    calcifying epithelial odontogenic tumor    dental enamel hypoplasia    ossifying fibroma    breast and colorectal cancer
    periodontitis    melanoma    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for ODAM:
    Ossifying fibroma

    ODAM for disorders           About GeneDecksing

    Genetic Association Database (GAD): ODAM

    Export disorders for ODAM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ODAM gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ODAM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein. (PubMed id 14647039)1, 2, 3, 9 Solomon A.... Westermark P. (J. Lab. Clin. Med. 2003)
    2. Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia. (PubMed id 17647262)1, 2 Moffatt P.... Nanci A. (J. Cell. Biochem. 2008)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification of secreted and membrane proteins in the rat incisor enamel organ using a signal-trap screening approach. (PubMed id 16674676)1, 9 Moffatt P....Nanci A. (Eur. J. Oral Sci. 2006)
    5. Odontogenic ameloblast-associated protein (ODAM) inhibits growth and migration of human melanoma cells and elicits PTEN elevation and inactivation of PI3K/AKT signaling. (PubMed id 23648148)1 Foster J.S....Kestler D.P. (BMC Cancer 2013)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Disruption of periodontal integrity induces expression of apin by epithelial cell rests of Malassez. (PubMed id 20572917)1 Nishio C....Nanci A. (J. Periodont. Res. 2010)
    8. Expanding the substantial interactome of NEMO using protein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (PLoS ONE 2010)
    9. Expression of odontogenic ameloblast-associated protein (ODAM) in dental and other epithelial neoplasms. (PubMed id 18472969)1 Kestler D.P....Solomon A. (Mol. Med. 2008)
    10. Odontogenic ameloblast-associated protein nature of the amyloid found in calcifying epithelial odontogenic tumors and unerupted tooth follicles. (PubMed id 18484335)1 Murphy C.L....Solomon A. (Amyloid 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54959 HGNC: 26043 AceView: APIN Ensembl:ENSG00000109205 euGenes: HUgn54959
    ECgene: ODAM H-InvDB: ODAM

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ODAM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ODAM gene:
    Search GeneIP for patents involving ODAM

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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