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Aliases for ODAM Gene

Aliases for ODAM Gene

  • Odontogenic, Ameloblast Asssociated 2 3 5
  • APIN 3 4

External Ids for ODAM Gene

Previous GeneCards Identifiers for ODAM Gene

  • GC04P071098
  • GC04P066865
  • GC04P071062

Summaries for ODAM Gene

GeneCards Summary for ODAM Gene

ODAM (Odontogenic, Ameloblast Asssociated) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

UniProtKB/Swiss-Prot for ODAM Gene

  • Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

Gene Wiki entry for ODAM Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODAM Gene

Genomics for ODAM Gene

Regulatory Elements for ODAM Gene

Genomic Location for ODAM Gene

Chromosome:
4
Start:
70,195,726 bp from pter
End:
70,204,576 bp from pter
Size:
8,851 bases
Orientation:
Plus strand

Genomic View for ODAM Gene

Genes around ODAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODAM Gene

Proteins for ODAM Gene

  • Protein details for ODAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1E959-ODAM_HUMAN
    Recommended name:
    Odontogenic ameloblast-associated protein
    Protein Accession:
    A1E959
    Secondary Accessions:
    • Q8WWE5
    • Q9NWZ9

    Protein attributes for ODAM Gene

    Size:
    279 amino acids
    Molecular mass:
    30777 Da
    Quaternary structure:
    • Interacts (via C-terminus) with ARHGEF5.
    Miscellaneous:
    • ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits.
    SequenceCaution:
    • Sequence=BAA91226.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ODAM Gene

Proteomics data for ODAM Gene at MOPED

Post-translational modifications for ODAM Gene

  • O-glycosylated.
  • Glycosylation at Thr 115, Thr 119, Thr 244, Ser 249, Thr 250, Thr 251, Thr 255, Ser 256, Thr 261, Thr 263, Thr 273, and Ser 275
  • Modification sites at PhosphoSitePlus

Other Protein References for ODAM Gene

No data available for DME Specific Peptides for ODAM Gene

Domains & Families for ODAM Gene

Protein Domains for ODAM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ODAM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1E959

UniProtKB/Swiss-Prot:

ODAM_HUMAN :
  • Belongs to the ODAM family.
Family:
  • Belongs to the ODAM family.
genes like me logo Genes that share domains with ODAM: view

No data available for Gene Families for ODAM Gene

Function for ODAM Gene

Molecular function for ODAM Gene

UniProtKB/Swiss-Prot Function:
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.
genes like me logo Genes that share phenotypes with ODAM: view

Animal Model Products

miRNA for ODAM Gene

miRTarBase miRNAs that target ODAM

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODAM Gene

Localization for ODAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODAM Gene

Secreted. Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ODAM Gene COMPARTMENTS Subcellular localization image for ODAM gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ODAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25911094
genes like me logo Genes that share ontologies with ODAM: view

Pathways & Interactions for ODAM Gene

genes like me logo Genes that share pathways with ODAM: view

Pathways by source for ODAM Gene

2 Reactome pathways for ODAM Gene

Gene Ontology (GO) - Biological Process for ODAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IMP 25911094
GO:0031214 biomineral tissue development IEA --
GO:0032956 regulation of actin cytoskeleton organization IDA 25911094
GO:0043547 positive regulation of GTPase activity IMP 25911094
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with ODAM: view

No data available for SIGNOR curated interactions for ODAM Gene

Drugs & Compounds for ODAM Gene

No Compound Related Data Available

Transcripts for ODAM Gene

Unigene Clusters for ODAM Gene

Odontogenic, ameloblast asssociated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ODAM Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for ODAM Gene

GeneLoc Exon Structure for
ODAM
ECgene alternative splicing isoforms for
ODAM

Expression for ODAM Gene

mRNA expression in normal human tissues for ODAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ODAM Gene

This gene is overexpressed in Minor Salivary Gland (x50.6).

Protein differential expression in normal tissues from HIPED for ODAM Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ODAM Gene



SOURCE GeneReport for Unigene cluster for ODAM Gene Hs.143811

mRNA Expression by UniProt/SwissProt for ODAM Gene

A1E959-ODAM_HUMAN
Tissue specificity: Expressed in the junctional epithelium of healthy teeth. In periodontitis, absent in the pocket epithelium of the diseased periodontium but is detected in the gingival crevicular fluid.
genes like me logo Genes that share expression patterns with ODAM: view

Protein tissue co-expression partners for ODAM Gene

Primer Products

In Situ Assay Products

Orthologs for ODAM Gene

This gene was present in the common ancestor of mammals.

Orthologs for ODAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODAM 35
  • 98.33 (n)
  • 96.77 (a)
ODAM 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ODAM 36
  • 72 (a)
OneToOne
ODAM 35
  • 82.31 (n)
  • 72.2 (a)
dog
(Canis familiaris)
Mammalia ODAM 35
  • 82.49 (n)
  • 75.54 (a)
ODAM 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Odam 16
Odam 36
  • 68 (a)
OneToOne
Odam 35
  • 75.95 (n)
  • 67.77 (a)
oppossum
(Monodelphis domestica)
Mammalia ODAM 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Odam 35
  • 75.33 (n)
  • 65.7 (a)
Species with no ortholog for ODAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ODAM Gene

ENSEMBL:
Gene Tree for ODAM (if available)
TreeFam:
Gene Tree for ODAM (if available)

Paralogs for ODAM Gene

No data available for Paralogs for ODAM Gene

Variants for ODAM Gene

Sequence variations from dbSNP and Humsavar for ODAM Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3196714 - 70,202,772(+) AGAGA(C/T)ACCAT reference, missense
VAR_039813 A colorectal cancer sample
rs966303 -- 70,196,358(-) AACTC(G/T)TTATT intron-variant, upstream-variant-2KB
rs1521514 -- 70,195,726(-) CAGCT(C/G)TACTG upstream-variant-2KB, utr-variant-5-prime
rs1383436 -- 70,196,125(-) TCTAT(A/G)TTGAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ODAM Gene

Variant ID Type Subtype PubMed ID
nsv517703 CNV Loss 19592680
nsv829963 CNV Gain 17160897
nsv879466 CNV Loss 21882294

Variation tolerance for ODAM Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.59; 82.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ODAM Gene

HapMap Linkage Disequilibrium report
ODAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODAM Gene

Disorders for ODAM Gene

Relevant External Links for ODAM

Genetic Association Database (GAD)
ODAM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ODAM

No disorders were found for ODAM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ODAM Gene

Publications for ODAM Gene

  1. Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein. (PMID: 14647039) Solomon A. … Westermark P. (J. Lab. Clin. Med. 2003) 2 3 4 23 67
  2. Identification of secreted and membrane proteins in the rat incisor enamel organ using a signal-trap screening approach. (PMID: 16674676) Moffatt P. … Nanci A. (Eur. J. Oral Sci. 2006) 3 23
  3. Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. (PMID: 25911094) Lee H.K. … Park J.C. (J. Biol. Chem. 2015) 3
  4. Odontogenic ameloblast-associated protein (ODAM) inhibits growth and migration of human melanoma cells and elicits PTEN elevation and inactivation of PI3K/AKT signaling. (PMID: 23648148) Foster J.S. … Kestler D.P. (BMC Cancer 2013) 3
  5. Expression pattern, subcellular localization, and functional implications of ODAM in ameloblasts, odontoblasts, osteoblasts, and various cancer cells. (PMID: 22387195) Lee H.K. … Park J.C. (Gene Expr. Patterns 2012) 3

Products for ODAM Gene

Sources for ODAM Gene

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