V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

ODAM Gene

protein-coding   GIFtS: 47

GC04P071098
odontogenic, ameloblast asssociated
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for ODAM

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
APIN 2, 3
APin 1
Apin 3
FLJ20513 1, 2
Descriptions
odontogenic ameloblast-associated protein 2
odontogenic, ameloblast asssociated 2
External Ids
HGNC: 260431
Entrez Gene: 549592
UniProtKB: A1E9593
Ensembl: ENSG000001092057
Search outside databases for aliases for ODAM gene

Summaries
for ODAM

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ODAM_HUMAN, A1E959
Function: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the
complex process that results in the initiation and generation of the tooth. May be incorporated in
the enamel matrix at the end of mineralization process

Gene Wiki entry for ODAM

Genomic Location
for ODAM

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ODAM gene  

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

ODAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P071098:     (about GC identifiers)

Start:
 71,096,833 bp from pter
End:
 71,104,882 bp from pter
Size:
 8,050 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000004.10  NT_077444.3  

Proteins
for ODAM

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ODAM_HUMAN, A1E959 (See protein sequence)
Recommended Name: Odontogenic ameloblast-associated protein precursor  
Size: 279 amino acids; 30777 Da
Subcellular location: Secreted (By similarity)
Miscellaneous: ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors
(CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic
entities arising mainly in the mandible and commonly associated with an unerupted or embedded
tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and,
notably, amyloid deposits
Secondary accessions: Q8WWE5 Q9NWZ9

Post-translational modifications:

  • O-glycosylated (By similarity)1


    • REFSEQ proteins: NP_060325.3  

    ENSEMBL proteins: 
    ENSP00000346548 ENSP00000379401 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (APIN)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    About this table

    Antibodies for ODAM: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (APIN)
    Novus Biologicals Antibody for ODAM

    Assays for ODAM: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ODAM

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A1E959

    UniProtKB/Swiss-Prot: ODAM_HUMAN, A1E959
    Similarity: Belongs to the ODAM family

    Gene Function
    for ODAM

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ODAM)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017855

                  Applied Biosystems Silencer® siRNAs for ODAM

                  Sigma-Aldrich siRNA for ODAM  
                         Sigma-Aldrich shRNA Panels and shRNA for ODAM  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ODAM
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017855
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017855
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_017855 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_017855

    UniProtKB/Swiss-Prot: ODAM_HUMAN, A1E959
    Function: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the
    complex process that results in the initiation and generation of the tooth. May be incorporated in
    the enamel matrix at the end of mineralization process

    Pathways & Interactions
    for ODAM

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for ODAM (ENSP000003465483) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTCH1ENSP000003323533STRING (score=.736)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503 ossification IEA--
    GO:0042475 odontogenesis of dentine-containing tooth IEA--
    About this table

    Drugs & Compounds
    for ODAM

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ODAM

    Transcripts
    for ODAM

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ODAM)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017855

                  Sigma-Aldrich siRNA for ODAM  
                         Sigma-Aldrich shRNA Panels and shRNA for ODAM  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_017855  

    REFSEQ mRNAs for ODAM gene: 

    NM_017855.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_017855  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017855
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017855
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_017855 

    Additional cDNA sequence: 

    AK000520.1 AK098169.1 AK225547.1 BC017796.1 EF113908.1 

    5 DOTS entries:

    DT.99935634  DT.91741889  DT.435385  DT.121249300  DT.121249513 

    24/29 AceView cDNA sequences (see all 29 ):

    BX101316 AA729875 AK098169 CD723278 NM_017855 CD724162 CD723326 BX487613 
    BC017796 AI697049 BV205862 AA025290 AI185064 BV205854 AK000520 BG194365 
    AA024396 BG188111 AA025291 BG536438 BG205136 BG218440 AA385519 BF083203 

    highest scoring ESTs for ODAM:

    AA024396 AA025290 AA025291 AA729875 AI185064 AI697049 AK000520 BC017796 BG536438 BX101316 

    Unigene Cluster for ODAM:

    Odontogenic, ameloblast asssociated
    Hs.143811  [show with all ESTs]
    Unigene Representative Sequence: NM_017855


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ODAM

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -                                       
    SP2:                                                                              
    SP3:                                      -                                       
    SP4:                                      -           -                           

    About this scheme

    ECgene alternative splicing isoforms for ODAM

    2 Ensembl transcripts including schematic representations:
    ENST00000354544  ENST00000396094  

    Expression
    for ODAM

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ODAM expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ODAM

    1 / 2 / 3

    3 probe-sets matching ODAM gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		61069_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 AA024396 1.00 1.00 1.00 1

    		220133_at2, 3 U133-A 1 1.00 1.00 -- -- NM_017855 0.60 1.00 0.82 1

    		220133_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AAGATATGTA

    SOURCE GeneReport for Unigene cluster: Hs.143811

    Orthologs
    for ODAM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ODAM gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ODAM1   -- odontogenic, ameloblast asssociated 81.33(n)
    74.4(a)    		 611755  XM_849468.1  XP_854561.1 
    chimpanzee
    (Pan troglodytes)    		 ODAM1   -- odontogenic, ameloblast asssociated 98.57(n)
    97.13(a)    		 461282  XM_517253.2  XP_517253.2 
    cow
    (Bos taurus)    		 ODAM1   -- odontogenic, ameloblast asssociated 82.31(n)
    72.69(a)    		 613976  XM_865243.2  XP_870336.2 
    rat
    (Rattus norvegicus)    		 Odam1   -- odontogenic, ameloblast asssociated 76.05(n)
    66.43(a)    		 641555  XM_001071185.1  XP_001071185.1 
    mouse
    (Mus musculus)    		 Odam1, 5 5 (45.00 cM)5
    		 odontogenic, ameloblast asssociated1, 5 77.18(n)1
    66.44(a)1    		 695921  NM_027128.11  NP_081404.11 
     AK0092985  BC1323945  (see all 9)
    About this table        Species with no ortholog for ODAM

    ENSEMBL Gene Tree for ODAM

    Paralogs
    for ODAM

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for ODAM

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/58 NCBI SNPs in ODAM are shown (see all 58 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 46)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs13834361,2
    		C,F,H,O71096431(-) TCTATA/GTTGAA 1 -- ng5117Minor allele frequency- T:0.02EA NA NS MN EU WA 1182
    rs9663031,2
    		A,C,F,H71096664(-) AACTCG/TTTATT 1 -- ng51 tfbs39Minor allele frequency- C:0.04NS EU EA WA 600
    rs31967141,2
    		C,F,H71103078(+) AGAGAC/TACCAT 1 I/T mis113Minor allele frequency- N:0.00NA EU EA WA MN 1216
    rs37561351,2
    		C,F,H71096493(-) ACCATG/AGGAGG 1 -- ng518Minor allele frequency- A:0.02EA NA EU WA 2032
    rs37561341,2
    		C,F,H71096518(+) CCTCTC/GCTTGT 1 -- ng51 trp38Minor allele frequency- G:0.02EA NA EU WA 1284
    rs171483311,2
    		F,H71096278(+) TCAATA/TTCACA 1 -- ng517Minor allele frequency- T:0.01NA EU EA WA 560
    rs18497121,2
    		C,F71104536(-) ACTAGT/CATTGA 1 -- ut31 ese33Minor allele frequency- C:0.19NA 142
    --
    rs176529991,2
    		F71095620(+) TGATTC/TCTAAC 1 -- ng513Minor allele frequency- T:0.19NA 134
    rs15215141,2
    		H71096032(-) CAGCTC/GTACTG 1 -- ng515Minor allele frequency- G:0.00MN EU EA WA 602
    rs177043511,2
    		F,H71097015(+) CGTCTC/TATGTC 1 L/L syn17Minor allele frequency- T:0.24NA EU EA WA 530
    About this table

    HapMap Linkage Disequilibrium images for ODAM (up to first 250kb)

    Disorders & Mutations
    for ODAM

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for ODAM

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for ODAM

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/15 PubMed articles for ODAM gene (see all 15 ):

    Search for ODAM

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ODAM

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 54959 HGNC: 26043 AceView: APIN Ensembl:ENSG00000109205 euGenes: HUgn54959
    ECgene: ODAM H-InvDB: ODAM

    Other Databases showing ODAM

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing ODAM

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for ODAM

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ODAM

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ODAM:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ODAM-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ODAM Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ODAM Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (APIN)
     Antibodies (APIN)
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Search for Recombinant Proteins
     Search for Antibodies
     Search OriGene for ODAM
     Search Tocris compounds for ODAM




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ODAM

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    ODAM Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com