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Aliases for OCSTAMP Gene

Aliases for OCSTAMP Gene

  • Osteoclast Stimulatory Transmembrane Protein 2 3 5
  • C20orf123 3 4
  • OC-STAMP 3 4
  • Chromosome 20 Open Reading Frame 123 2
  • Transmembrane Protein C20orf123 3
  • DJ257E24.3 3

External Ids for OCSTAMP Gene

Previous HGNC Symbols for OCSTAMP Gene

  • C20orf123

Previous GeneCards Identifiers for OCSTAMP Gene

  • GC20M045170

Summaries for OCSTAMP Gene

Entrez Gene Summary for OCSTAMP Gene

  • The protein encoded by this gene is orthologous to the mouse osteoclast stimulatory transmembrane protein (OCSTAMP), which is a membrane-anchored cell surface receptor that promotes nucleation of osteoclasts. The mouse protein is also involved in bone resorption and osteoclast differentiation. [provided by RefSeq, Feb 2017]

GeneCards Summary for OCSTAMP Gene

OCSTAMP (Osteoclast Stimulatory Transmembrane Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for OCSTAMP Gene

  • Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OCSTAMP Gene

Genomics for OCSTAMP Gene

Regulatory Elements for OCSTAMP Gene

Enhancers for OCSTAMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G046584 1.1 ENCODE dbSUPER 11.5 -34.1 -34104 0.1 ELF3 SOX13 FOXA2 SAP130 CEBPG ZNF384 ZNF644 THRB RARA FOXK2 OCSTAMP ENSG00000273893
GH20G046582 1 ENCODE dbSUPER 11.5 -33.0 -33016 1.3 CTCF USF1 ZMYM3 MAX CEBPG RBBP5 RAD21 ZIC2 ZNF366 POLR2A OCSTAMP ENSG00000273893
GH20G046606 1 ENCODE 11 -57.0 -56966 1.4 FOXA2 MLX ARID4B DMAP1 ZNF48 SLC30A9 SP5 ZHX2 MXD4 MIER2 SLC2A10 SLC13A3 OCSTAMP ENSG00000273893
GH20G046683 1 ENCODE 10.9 -133.4 -133396 2.3 ATF1 FOXA2 CREB3L1 ARNT ZNF2 YY1 TCF12 ZNF121 ZNF143 ZNF263 TP53RK ZNF335 SLC2A10 OCSTAMP SLC13A3 ENSG00000273893
GH20G046521 0.9 ENCODE 11.4 +29.4 29408 0.2 ELF3 FOXA2 WRNIP1 ARID4B ZNF48 ZSCAN9 RAD21 ZNF143 PCBP1 THAP11 OCSTAMP SLC2A10 SLC13A3 GC20M046507 ZNF334
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OCSTAMP on UCSC Golden Path with GeneCards custom track

Genomic Location for OCSTAMP Gene

Chromosome:
20
Start:
46,540,946 bp from pter
End:
46,550,574 bp from pter
Size:
9,629 bases
Orientation:
Minus strand

Genomic View for OCSTAMP Gene

Genes around OCSTAMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OCSTAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OCSTAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OCSTAMP Gene

Proteins for OCSTAMP Gene

  • Protein details for OCSTAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR26-OCSTP_HUMAN
    Recommended name:
    Osteoclast stimulatory transmembrane protein
    Protein Accession:
    Q9BR26

    Protein attributes for OCSTAMP Gene

    Size:
    566 amino acids
    Molecular mass:
    61579 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AL935075; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for OCSTAMP Gene

Post-translational modifications for OCSTAMP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OCSTAMP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OCSTAMP Gene

Domains & Families for OCSTAMP Gene

Protein Domains for OCSTAMP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OCSTAMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OCSTAMP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OCSTAMP Gene

Function for OCSTAMP Gene

Molecular function for OCSTAMP Gene

UniProtKB/Swiss-Prot Function:
Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).
genes like me logo Genes that share phenotypes with OCSTAMP: view

Animal Models for OCSTAMP Gene

MGI Knock Outs for OCSTAMP:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OCSTAMP Gene

Localization for OCSTAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OCSTAMP Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OCSTAMP gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for OCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OCSTAMP: view

Pathways & Interactions for OCSTAMP Gene

SuperPathways for OCSTAMP Gene

No Data Available

Interacting Proteins for OCSTAMP Gene

Gene Ontology (GO) - Biological Process for OCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
GO:0034241 positive regulation of macrophage fusion IEA --
GO:0045672 positive regulation of osteoclast differentiation IEA,ISS --
GO:0071356 cellular response to tumor necrosis factor ISS,IEA --
GO:0071391 cellular response to estrogen stimulus ISS,IEA --
genes like me logo Genes that share ontologies with OCSTAMP: view

No data available for Pathways by source and SIGNOR curated interactions for OCSTAMP Gene

Drugs & Compounds for OCSTAMP Gene

No Compound Related Data Available

Transcripts for OCSTAMP Gene

mRNA/cDNA for OCSTAMP Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OCSTAMP Gene

Osteoclast stimulatory transmembrane protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OCSTAMP Gene

No ASD Table

Relevant External Links for OCSTAMP Gene

GeneLoc Exon Structure for
OCSTAMP
ECgene alternative splicing isoforms for
OCSTAMP

Expression for OCSTAMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OCSTAMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OCSTAMP Gene

This gene is overexpressed in Testis (x9.0) and Kidney - Cortex (x5.9).

Protein differential expression in normal tissues from HIPED for OCSTAMP Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OCSTAMP Gene



Protein tissue co-expression partners for OCSTAMP Gene

NURSA nuclear receptor signaling pathways regulating expression of OCSTAMP Gene:

OCSTAMP

SOURCE GeneReport for Unigene cluster for OCSTAMP Gene:

Hs.526636

Evidence on tissue expression from TISSUES for OCSTAMP Gene

  • Bone(2)
genes like me logo Genes that share expression patterns with OCSTAMP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OCSTAMP Gene

Orthologs for OCSTAMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for OCSTAMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OCSTAMP 34 35
  • 98.99 (n)
cow
(Bos Taurus)
Mammalia OCSTAMP 34 35
  • 79.67 (n)
dog
(Canis familiaris)
Mammalia OCSTAMP 34 35
  • 78.31 (n)
rat
(Rattus norvegicus)
Mammalia Zfp334 34
  • 77.08 (n)
mouse
(Mus musculus)
Mammalia Ocstamp 34 16 35
  • 76.99 (n)
oppossum
(Monodelphis domestica)
Mammalia OCSTAMP 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20H20ORF123 34
  • 50.36 (n)
OCSTAMP 35
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OCSTAMP 35
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493211 34
  • 47.16 (n)
zebrafish
(Danio rerio)
Actinopterygii ocstamp 34 35
  • 43.45 (n)
Species where no ortholog for OCSTAMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OCSTAMP Gene

ENSEMBL:
Gene Tree for OCSTAMP (if available)
TreeFam:
Gene Tree for OCSTAMP (if available)

Paralogs for OCSTAMP Gene

No data available for Paralogs for OCSTAMP Gene

Variants for OCSTAMP Gene

Sequence variations from dbSNP and Humsavar for OCSTAMP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000137103 -- 46,552,544(+) GAGGC(C/G)TTAGT upstream-variant-2KB
rs1000173141 -- 46,550,749(+) GCTGC(C/T)TCATC upstream-variant-2KB
rs1000203180 -- 46,549,582(+) GGTGG(A/T)AGGAC intron-variant
rs1000356828 -- 46,546,773(+) TGGAC(C/G)TTCTA intron-variant, upstream-variant-2KB
rs1000693130 -- 46,545,652(+) ATGCC(G/T)ACTCC reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for OCSTAMP Gene

Variant ID Type Subtype PubMed ID
nsv1061899 CNV loss 25217958
nsv833994 CNV gain 17160897

Variation tolerance for OCSTAMP Gene

Gene Damage Index Score: 3.75; 57.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OCSTAMP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OCSTAMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OCSTAMP Gene

Disorders for OCSTAMP Gene

Relevant External Links for OCSTAMP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OCSTAMP

No disorders were found for OCSTAMP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OCSTAMP Gene

Publications for OCSTAMP Gene

  1. Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation. (PMID: 18064667) Yang M. … Odgren P.R. (J. Cell. Physiol. 2008) 2 3 64
  2. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 4 64

Products for OCSTAMP Gene

Sources for OCSTAMP Gene

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