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Aliases for OCSTAMP Gene

Aliases for OCSTAMP Gene

  • Osteoclast Stimulatory Transmembrane Protein 2 3 5
  • C20orf123 3 4
  • OC-STAMP 3 4
  • Chromosome 20 Open Reading Frame 123 2
  • Transmembrane Protein C20orf123 3
  • DJ257E24.3 3

External Ids for OCSTAMP Gene

Previous HGNC Symbols for OCSTAMP Gene

  • C20orf123

Previous GeneCards Identifiers for OCSTAMP Gene

  • GC20M045170

Summaries for OCSTAMP Gene

GeneCards Summary for OCSTAMP Gene

OCSTAMP (Osteoclast Stimulatory Transmembrane Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for OCSTAMP Gene

  • Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OCSTAMP Gene

Genomics for OCSTAMP Gene

Regulatory Elements for OCSTAMP Gene

Enhancers for OCSTAMP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OCSTAMP on UCSC Golden Path with GeneCards custom track

Promoters for OCSTAMP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OCSTAMP on UCSC Golden Path with GeneCards custom track

Genomic Location for OCSTAMP Gene

Chromosome:
20
Start:
46,540,946 bp from pter
End:
46,550,574 bp from pter
Size:
9,629 bases
Orientation:
Minus strand

Genomic View for OCSTAMP Gene

Genes around OCSTAMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OCSTAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OCSTAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OCSTAMP Gene

Proteins for OCSTAMP Gene

  • Protein details for OCSTAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR26-OCSTP_HUMAN
    Recommended name:
    Osteoclast stimulatory transmembrane protein
    Protein Accession:
    Q9BR26

    Protein attributes for OCSTAMP Gene

    Size:
    566 amino acids
    Molecular mass:
    61579 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AL935075; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for OCSTAMP Gene

Proteomics data for OCSTAMP Gene at MOPED

Post-translational modifications for OCSTAMP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OCSTAMP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OCSTAMP Gene

Domains & Families for OCSTAMP Gene

Protein Domains for OCSTAMP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OCSTAMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OCSTAMP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OCSTAMP Gene

Function for OCSTAMP Gene

Molecular function for OCSTAMP Gene

UniProtKB/Swiss-Prot Function:
Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).

Phenotypes for OCSTAMP Gene

MGI mutant phenotypes for OCSTAMP:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with OCSTAMP: view

Animal Models for OCSTAMP Gene

MGI Knock Outs for OCSTAMP:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OCSTAMP Gene

Localization for OCSTAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OCSTAMP Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OCSTAMP Gene COMPARTMENTS Subcellular localization image for OCSTAMP gene
Compartment Confidence
plasma membrane 3
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for OCSTAMP Gene

Pathways & Interactions for OCSTAMP Gene

SuperPathways for OCSTAMP Gene

No Data Available

Interacting Proteins for OCSTAMP Gene

Gene Ontology (GO) - Biological Process for OCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034241 positive regulation of macrophage fusion IEA --
GO:0071356 cellular response to tumor necrosis factor IEA,ISS --
GO:0072674 multinuclear osteoclast differentiation IEA,ISS --
GO:0090290 positive regulation of osteoclast proliferation IEA,ISS --
genes like me logo Genes that share ontologies with OCSTAMP: view

No data available for Pathways by source and SIGNOR curated interactions for OCSTAMP Gene

Drugs & Compounds for OCSTAMP Gene

No Compound Related Data Available

Transcripts for OCSTAMP Gene

mRNA/cDNA for OCSTAMP Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OCSTAMP Gene

Osteoclast stimulatory transmembrane protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OCSTAMP Gene

No ASD Table

Relevant External Links for OCSTAMP Gene

GeneLoc Exon Structure for
OCSTAMP
ECgene alternative splicing isoforms for
OCSTAMP

Expression for OCSTAMP Gene

mRNA expression in normal human tissues for OCSTAMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OCSTAMP Gene

This gene is overexpressed in Testis (x9.0) and Kidney - Cortex (x5.9).

Protein differential expression in normal tissues from HIPED for OCSTAMP Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OCSTAMP Gene



SOURCE GeneReport for Unigene cluster for OCSTAMP Gene Hs.526636

genes like me logo Genes that share expression patterns with OCSTAMP: view

Protein tissue co-expression partners for OCSTAMP Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for OCSTAMP Gene

Orthologs for OCSTAMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for OCSTAMP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OCSTAMP 35
  • 79.67 (n)
  • 73.44 (a)
OCSTAMP 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OCSTAMP 35
  • 78.31 (n)
  • 73.66 (a)
OCSTAMP 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ocstamp 35
  • 76.99 (n)
  • 72.61 (a)
Ocstamp 16
Ocstamp 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OCSTAMP 35
  • 98.99 (n)
  • 98.7 (a)
OCSTAMP 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp334 35
  • 77.08 (n)
  • 72.54 (a)
oppossum
(Monodelphis domestica)
Mammalia OCSTAMP 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves OCSTAMP 36
  • 33 (a)
OneToOne
C20H20ORF123 35
  • 50.36 (n)
  • 36.34 (a)
lizard
(Anolis carolinensis)
Reptilia OCSTAMP 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493211 35
  • 47.16 (n)
  • 32.84 (a)
zebrafish
(Danio rerio)
Actinopterygii ocstamp 35
  • 43.45 (n)
  • 29.4 (a)
ocstamp 36
  • 25 (a)
OneToOne
Species with no ortholog for OCSTAMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OCSTAMP Gene

ENSEMBL:
Gene Tree for OCSTAMP (if available)
TreeFam:
Gene Tree for OCSTAMP (if available)

Paralogs for OCSTAMP Gene

No data available for Paralogs for OCSTAMP Gene

Variants for OCSTAMP Gene

Sequence variations from dbSNP and Humsavar for OCSTAMP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs847079 - 46,541,282(-) ATAGG(C/T)CTGGA reference, synonymous-codon, missense
rs2411 -- 46,541,166(-) TCTAC(C/T)TGTTA utr-variant-3-prime
rs85021 -- 46,550,856(+) ttagc(C/T)ccatt upstream-variant-2KB
rs126911 -- 46,549,808(+) CCACt(C/G)tgtgt intron-variant
rs126912 -- 46,551,540(+) tgaac(A/C)cttac upstream-variant-2KB

Variation tolerance for OCSTAMP Gene

Gene Damage Index Score: 3.75; 57.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OCSTAMP Gene

HapMap Linkage Disequilibrium report
OCSTAMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OCSTAMP Gene

Disorders for OCSTAMP Gene

Relevant External Links for OCSTAMP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OCSTAMP

No disorders were found for OCSTAMP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OCSTAMP Gene

Publications for OCSTAMP Gene

  1. Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation. (PMID: 18064667) Yang M. … Odgren P.R. (J. Cell. Physiol. 2008) 2 3 67
  2. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for OCSTAMP Gene

Sources for OCSTAMP Gene

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