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Aliases for OCSTAMP Gene

Aliases for OCSTAMP Gene

  • Osteoclast Stimulatory Transmembrane Protein 2 3
  • C20orf123 3 4
  • OC-STAMP 3 4
  • Chromosome 20 Open Reading Frame 123 2
  • Transmembrane Protein C20orf123 3
  • DJ257E24.3 3

External Ids for OCSTAMP Gene

Previous Symbols for OCSTAMP Gene

  • C20orf123

Summaries for OCSTAMP Gene

GeneCards Summary for OCSTAMP Gene

OCSTAMP (Osteoclast Stimulatory Transmembrane Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for OCSTAMP Gene

  • Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OCSTAMP Gene

Genomics for OCSTAMP Gene

Genomic Location for OCSTAMP Gene

Start:
46,540,946 bp from pter
End:
46,550,574 bp from pter
Size:
9,629 bases
Orientation:
Minus strand

Genomic View for OCSTAMP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OCSTAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OCSTAMP Gene

No data available for Regulatory Elements for OCSTAMP Gene

Proteins for OCSTAMP Gene

  • Protein details for OCSTAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR26-OCSTP_HUMAN
    Recommended name:
    Osteoclast stimulatory transmembrane protein
    Protein Accession:
    Q9BR26
    Secondary Accessions:

    Protein attributes for OCSTAMP Gene

    Size:
    566 amino acids
    Molecular mass:
    61579 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AL935075; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for OCSTAMP Gene

Proteomics data for OCSTAMP Gene at MOPED

Post-translational modifications for OCSTAMP Gene

No Post-translational modifications

Other Protein References for OCSTAMP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OCSTAMP Gene

Domains for OCSTAMP Gene

Protein Domains for OCSTAMP Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OCSTAMP: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for OCSTAMP Gene

Function for OCSTAMP Gene

Molecular function for OCSTAMP Gene

UniProtKB/Swiss-Prot Function: Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OCSTAMP Gene

Localization for OCSTAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OCSTAMP Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OCSTAMP: view

No data available for Subcellular locations from COMPARTMENTS for OCSTAMP Gene

Pathways for OCSTAMP Gene

SuperPathways for OCSTAMP Gene

No Data Available

Interacting Proteins for OCSTAMP Gene

Gene Ontology (GO) - Biological Process for OCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034241 positive regulation of macrophage fusion IEA --
GO:0045672 positive regulation of osteoclast differentiation ISS --
GO:0071356 cellular response to tumor necrosis factor ISS --
GO:0071391 cellular response to estrogen stimulus ISS --
GO:0072674 multinuclear osteoclast differentiation ISS --
genes like me logo Genes that share ontologies with OCSTAMP: view

No data available for Pathways by source for OCSTAMP Gene

Transcripts for OCSTAMP Gene

mRNA/cDNA for OCSTAMP Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OCSTAMP Gene

Osteoclast stimulatory transmembrane protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OCSTAMP Gene

No ASD Table

Relevant External Links for OCSTAMP Gene

GeneLoc Exon Structure for
OCSTAMP
ECgene alternative splicing isoforms for
OCSTAMP

Expression for OCSTAMP Gene

mRNA expression in normal human tissues for OCSTAMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OCSTAMP Gene

This gene is overexpressed in Testis (9.0) and Kidney - Cortex (5.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OCSTAMP Gene

SOURCE GeneReport for Unigene cluster for OCSTAMP Gene Hs.526636

genes like me logo Genes that share expressions with OCSTAMP: view

No data available for mRNA Expression by UniProt/SwissProt for OCSTAMP Gene

Orthologs for OCSTAMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for OCSTAMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OCSTAMP 35
  • 98.99 (n)
  • 98.7 (a)
OCSTAMP 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OCSTAMP 35
  • 79.67 (n)
  • 73.44 (a)
OCSTAMP 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OCSTAMP 35
  • 78.31 (n)
  • 73.66 (a)
OCSTAMP 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ocstamp 35
  • 76.99 (n)
  • 72.61 (a)
Ocstamp 16
Ocstamp 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OCSTAMP 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp334 35
  • 77.08 (n)
  • 72.54 (a)
chicken
(Gallus gallus)
Aves C20H20ORF123 35
  • 50.36 (n)
  • 36.34 (a)
OCSTAMP 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OCSTAMP 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493211 35
  • 47.16 (n)
  • 32.84 (a)
zebrafish
(Danio rerio)
Actinopterygii ocstamp 35
  • 43.45 (n)
  • 29.4 (a)
ocstamp 36
  • 25 (a)
OneToOne
Species with no ortholog for OCSTAMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OCSTAMP Gene

ENSEMBL:
Gene Tree for OCSTAMP (if available)
TreeFam:
Gene Tree for OCSTAMP (if available)

Paralogs for OCSTAMP Gene

No data available for Paralogs for OCSTAMP Gene

Variants for OCSTAMP Gene

Sequence variations from dbSNP and Humsavar for OCSTAMP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2411 -- 46,541,166(-) TCTAC(C/T)TGTTA utr-variant-3-prime
rs85021 -- 46,550,856(+) ttagc(C/T)ccatt upstream-variant-2KB
rs126911 -- 46,549,808(+) CCACt(C/G)tgtgt intron-variant
rs126912 -- 46,551,540(+) tgaac(A/C)cttac upstream-variant-2KB
rs169344 -- 46,544,875(+) CAGTC(C/T)GACAT intron-variant

Relevant External Links for OCSTAMP Gene

HapMap Linkage Disequilibrium report
OCSTAMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OCSTAMP Gene

Disorders for OCSTAMP Gene

No disorders were found for OCSTAMP Gene.

No data available for UniProtKB/Swiss-Prot for OCSTAMP Gene

Publications for OCSTAMP Gene

  1. Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation. (PMID: 18064667) Yang M. … Odgren P.R. (J. Cell. Physiol. 2008) 2 3
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 4
  3. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for OCSTAMP Gene

Sources for OCSTAMP Gene

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