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OCSTAMP Gene

protein-coding   GIFtS: 30
GCID: GC20M045170

Osteoclast Stimulatory Transmembrane Protein

(Previous name: chromosome 20 open reading frame 123)
(Previous symbol: C20orf123)
  Search for OCSTAMP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Osteoclast Stimulatory Transmembrane Protein1 2
C20orf1231 2 3
OC-STAMP2 3
Chromosome 20 Open Reading Frame 1231
dJ257E24.32
Transmembrane Protein C20orf1232

External Ids:    HGNC: 161161   Entrez Gene: 1285062   Ensembl: ENSG000001496357   UniProtKB: Q9BR263   

Export aliases for OCSTAMP gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OCSTAMP Gene:
OCSTAMP (osteoclast stimulatory transmembrane protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: OCSTP_HUMAN, Q9BR26
Function: Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates
with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in
osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated
osteoclast maturation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Search for regulatory transcription factor binding sites for OCSTAMP
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OCSTAMP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

OCSTAMP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OCSTAMP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M045170:  view genomic region     (about GC identifiers)

Start:
45,169,585 bp from pter      End:
45,179,213 bp from pter
Size:
9,629 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OCSTP_HUMAN, Q9BR26 (See protein sequence)
Recommended Name: Osteoclast stimulatory transmembrane protein  
Size: 566 amino acids; 61579 Da
Sequence caution: Sequence=AL935075; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for OCSTAMP: NX_Q9BR26

Explore proteomics data for OCSTAMP at MOPED


See OCSTAMP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_542452.1  
ENSEMBL proteins: 
 ENSP00000279028  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR012858 DC_STAMP-like

Graphical View of Domain Structure for InterPro Entry Q9BR26

ProtoNet protein and cluster: Q9BR26

1 Blocks protein domain: IPB012858 DC-STAMP-like


Find genes that share domains with OCSTAMP           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: OCSTP_HUMAN, Q9BR26
Function: Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates
with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in
osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated
osteoclast maturation (By similarity)

Phenotypes:
     1 MGI phenotypic allele for Ocstamp (no phenotypes)


Find genes that share phenotypes with OCSTAMP           About GenesLikeMe

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
OCSTP_HUMAN, Q9BR26: Membrane; Multi-pass membrane protein (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with OCSTAMP           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OCSTAMP
Interactions:

    Search GeneGlobe Interaction Network for OCSTAMP

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0034241positive regulation of macrophage fusion IEA--
GO:0045672positive regulation of osteoclast differentiation ISS--
GO:0071356cellular response to tumor necrosis factor ISS--
GO:0071391cellular response to estrogen stimulus ISS--
GO:0072674multinuclear osteoclast differentiation ISS--

Find genes that share ontologies with OCSTAMP           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for OCSTAMP (OCSTP)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OCSTAMP gene: 
NM_080721.2  

Unigene Cluster for OCSTAMP:

Osteoclast stimulatory transmembrane protein
Hs.526636  [show with all ESTs]
Unigene Representative Sequence: NM_080721
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000279028(uc010zxu.1)
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3 DOTS entries:

DT.91733972  DT.99999532  DT.99933750 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OCSTAMP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATTTCTCGA
OCSTAMP Expression
About this image


OCSTAMP expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Bone (Muscoskeletal System)
         Zeugopod Periosteum
 
 Blood (Cardiovascular System)
         Conventional Dendritic Cells I Spleen
 
 Spleen (Hematopoietic System)
         Conventional Dendritic Cells I Spleen
OCSTAMP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OCSTAMP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.526636
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for OCSTAMP gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ocstamp1 , 5 osteoclast stimulatory transmembrane protein1, 5 76.99(n)1
72.61(a)1
  2 (85.53 cM)5
746141  NM_029021.11  NP_083297.11 
 1653937605 
chicken
(Gallus gallus)
Aves C20H20ORF1231 chromosome 20 open reading frame, human C20orf123 50.36(n)
36.34(a)
  419205  XM_417382.3  XP_417382.2 
lizard
(Anolis carolinensis)
Reptilia OCSTAMP6
osteoclast stimulatory transmembrane protein
35(a)
1 ↔ 1
4(144558667-144563750)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004932111 osteoclast stimulatory transmembrane protein-like 47.16(n)
32.84(a)
  100493211  XM_002933187.2  XP_002933233.2 
zebrafish
(Danio rerio)
Actinopterygii ocstamp1 osteoclast stimulatory transmembrane protein 43.45(n)
29.4(a)
  541527  NM_001014340.1  NP_001014362.1 


ENSEMBL Gene Tree for OCSTAMP (if available)
TreeFam Gene Tree for OCSTAMP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OCSTAMP (see all 334)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1902604571,2
--45169159(+) GATAAC/TAATGC 1 -- ds50010--------
rs60630021,2
--45169219(+) tttgtC/Tctaaa 1 -- ds50010--------
rs2023831,2
C,F,A--45169236(+) tccatA/Tcatag 1 -- ds50012Minor allele frequency- T:0.07CSA WA 120
rs1177810981,2
C,F--45169331(+) GTTCAA/GACTGT 1 -- ds50011Minor allele frequency- G:0.02NA 120
rs1868814701,2
--45169378(+) AGCTGC/TTTCTG 1 -- ds50010--------
rs1919660001,2
--45169406(+) CTGTAA/CATCTC 1 -- ds50010--------
rs1832909251,2
--45169444(+) CTGACA/GATGTT 1 -- ds50010--------
rs756221841,2
F--45169528(+) ATTTCA/GTTTAA 1 -- ds50013Minor allele frequency- G:0.06CSA WA 121
rs1879224221,2
C--45169529(+) TTTCAC/TTTAAG 1 -- ds50010--------
rs1171599531,2
C,F--45169664(+) ATAACG/ATAATC 2 -- ut31 ds50011Minor allele frequency- A:0.04EA 120

HapMap Linkage Disequilibrium report for OCSTAMP (45169585 - 45179213 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for OCSTAMP: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing OCSTAMP
DNA2.0 Custom Variant and Variant Library Synthesis for OCSTAMP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OCSTAMP gene integrated from 10 sources:
(articles sorted by number of sources associating them with OCSTAMP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation. (PubMed id 18064667)1, 3 Yang M....Odgren P.R. (J. Cell. Physiol. 2008)
  2. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)
  3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)2 Deloukas P....Rogers J. (Nature 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 128506 HGNC: 16116 Ensembl:ENSG00000149635 euGenes: HUgn128506 ECgene: OCSTAMP
H-InvDB: OCSTAMP

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OCSTAMP Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OCSTAMP gene:
Search GeneIP for patents involving OCSTAMP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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