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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OCSTAMP Gene

protein-coding   GIFtS: 31
GCID: GC20M045170

Osteoclast Stimulatory Transmembrane Protein

(Previous name: chromosome 20 open reading frame 123)
(Previous symbol: C20orf123)
  Search for OCSTAMP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Osteoclast Stimulatory Transmembrane Protein1 2
C20orf1231 2 3
OC-STAMP2 3
Chromosome 20 Open Reading Frame 1231
dJ257E24.32
Transmembrane Protein C20orf1232

External Ids:    HGNC: 161161   Entrez Gene: 1285062   Ensembl: ENSG000001496357   UniProtKB: Q9BR263   

Export aliases for OCSTAMP gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OCSTAMP Gene: 
OCSTAMP (osteoclast stimulatory transmembrane protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: OCSTP_HUMAN, Q9BR26
Function: Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates
with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in
osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated
osteoclast maturation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for OCSTAMP
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCSTAMP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

OCSTAMP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OCSTAMP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M045170:  view genomic region     (about GC identifiers)

Start:
45,169,585 bp from pter      End:
45,179,213 bp from pter
Size:
9,629 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OCSTP_HUMAN, Q9BR26 (See protein sequence)
Recommended Name: Osteoclast stimulatory transmembrane protein  
Size: 566 amino acids; 61579 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AL935075; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for OCSTAMP: NX_Q9BR26

Explore proteomics data for OCSTAMP at MOPED 

OCSTAMP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OCSTAMP Protein Expression

REFSEQ proteins: NP_542452.1  
ENSEMBL proteins: 
 ENSP00000279028  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

OCSTAMP for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR012858 DC_STAMP-like

Graphical View of Domain Structure for InterPro Entry Q9BR26

ProtoNet protein and cluster: Q9BR26

1 Blocks protein domain: IPB012858 DC-STAMP-like


OCSTAMP for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: OCSTP_HUMAN, Q9BR26
Function: Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates
with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in
osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated
osteoclast maturation (By similarity)

Phenotypes:
     1 MGI phenotypic allele for Ocstamp (no phenotypes)


OCSTAMP for phenotypes           About GeneDecksing

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OCSTAMP

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0045672positive regulation of osteoclast differentiation ISS--
GO:0071356cellular response to tumor necrosis factor ISS--
GO:0071391cellular response to estrogen stimulus ISS--
GO:0072674multinuclear osteoclast differentiation ISS--
GO:0090290positive regulation of osteoclast proliferation ISS--

OCSTAMP for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OCSTAMP (OCSTP)

Search CenterWatch for drugs/clinical trials and news about OCSTAMP / OCSTP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OCSTAMP gene: 
NM_080721.2  

Unigene Cluster for OCSTAMP:

Osteoclast stimulatory transmembrane protein
Hs.526636  [show with all ESTs]
Unigene Representative Sequence: NM_080721
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000279028(uc010zxu.1)
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3 DOTS entries:

DT.91733972  DT.99999532  DT.99933750 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OCSTAMP expression in normal human tissues (normalized intensities)      OCSTAMP embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATTTCTCGA
OCSTAMP Expression
About this image


OCSTAMP expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Bone (Muscoskeletal System)
         Zeugopod Periosteum
 
 Blood (Cardiovascular System)
         Conventional Dendritic Cells I Spleen
 
 Spleen (Hematopoietic System)
         Conventional Dendritic Cells I Spleen

See OCSTAMP Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.526636
    SABiosciences Custom PCR Arrays for OCSTAMP
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCSTAMP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OCSTAMP gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ocstamp1 , 5 osteoclast stimulatory transmembrane protein1, 5 77.01(n)1
72.77(a)1
  2 (85.53 cM)5
746141  NM_029021.11  NP_083297.11 
 1653937605 
chicken
(Gallus gallus)
Aves C20H20orf1231 chromosome 20 open reading frame, human C20orf123 50.28(n)
36.34(a)
  419205  XM_417382.2  XP_417382.2 
lizard
(Anolis carolinensis)
Reptilia OCSTAMP6
Uncharacterized protein
34(a)
1 ↔ 1
4(144558667-144563750)
zebrafish
(Danio rerio)
Actinopterygii ocstamp1 osteoclast stimulatory transmembrane protein 42.63(n)
29.09(a)
  541527  NM_001014340.1  NP_001014362.1 


ENSEMBL Gene Tree for OCSTAMP (if available)
TreeFam Gene Tree for OCSTAMP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/334 SNPs in OCSTAMP are shown (see all 334)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1902604571,2
--45169159(+) GATAAC/TAATGC 1 -- ds50010--------
rs60630021,2
--45169219(+) tttgtC/Tctaaa 1 -- ds50010--------
rs2023831,2
C,F,A--45169236(+) tccatA/Tcatag 1 -- ds50012Minor allele frequency- T:0.07CSA WA 120
rs1177810981,2
C,F--45169331(+) GTTCAA/GACTGT 1 -- ds50011Minor allele frequency- G:0.02NA 120
rs1868814701,2
--45169378(+) AGCTGC/TTTCTG 1 -- ds50010--------
rs1919660001,2
--45169406(+) CTGTAA/CATCTC 1 -- ds50010--------
rs1832909251,2
--45169444(+) CTGACA/GATGTT 1 -- ds50010--------
rs756221841,2
F--45169528(+) ATTTCA/GTTTAA 1 -- ds50013Minor allele frequency- G:0.06CSA WA 121
rs1879224221,2
C--45169529(+) TTTCAC/TTTAAG 1 -- ds50010--------
rs1171599531,2
C,F--45169664(+) ATAACG/ATAATC 2 -- ut31 ds50011Minor allele frequency- A:0.04EA 120

HapMap Linkage Disequilibrium report for OCSTAMP (45169585 - 45179213 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for OCSTAMP: --
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OCSTAMP gene integrated from 9 sources:
(articles sorted by number of sources associating them with OCSTAMP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Osteoclast stimulatory transmembrane protein (OC-STAM P), a novel protein induced by RANKL that promotes osteoclast differentiation. (PubMed id 18064667)1, 3 Yang M....Odgren P.R. (2008)
  2. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
  3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)2 Deloukas P....Rogers J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 128506 HGNC: 16116 Ensembl:ENSG00000149635 euGenes: HUgn128506 ECgene: OCSTAMP
H-InvDB: OCSTAMP

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OCSTAMP Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OCSTAMP gene:
Search GeneIP for patents involving OCSTAMP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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