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Aliases for OCM2 Gene

Aliases for OCM2 Gene

  • Oncomodulin 2 2 3 5
  • Putative Oncomodulin-2 3
  • Parvalbumin Beta 3
  • OCMN 4
  • OCM 3
  • OM 3

External Ids for OCM2 Gene

Previous GeneCards Identifiers for OCM2 Gene

  • GC07M097454
  • GC07M097614
  • GC07M092214

Summaries for OCM2 Gene

Entrez Gene Summary for OCM2 Gene

  • This gene is similar to the oncomodulin gene, a high-affinity calcium ion-binding protein that belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for OCM2 Gene

OCM2 (Oncomodulin 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is OCM.

Gene Wiki entry for OCM2 Gene

Additional gene information for OCM2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OCM2 Gene

Genomics for OCM2 Gene

Regulatory Elements for OCM2 Gene

Enhancers for OCM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H097974 0.6 ENCODE 0.4 +17.7 17676 0.3 SP1 PKNOX1 NFYB MAX SP2 ZBTB33 OR7E38P ENSG00000284707 OCM2
GH07H097973 0.5 ENCODE 0.4 +17.9 17885 0 SP1 PKNOX1 NFYB SP2 ZBTB33 ENSG00000284707 OCM2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OCM2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OCM2 Gene

Genomic Locations for OCM2 Gene
6,486 bases
Minus strand

Genomic View for OCM2 Gene

Genes around OCM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OCM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OCM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OCM2 Gene

Proteins for OCM2 Gene

  • Protein details for OCM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative oncomodulin-2
    Protein Accession:
    Secondary Accessions:
    • P32930
    • Q6ISI5
    • Q75MW0

    Protein attributes for OCM2 Gene

    109 amino acids
    Molecular mass:
    12129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OCM2 Gene

Post-translational modifications for OCM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OCM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OCM2 Gene

Domains & Families for OCM2 Gene

Gene Families for OCM2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OCM2 Gene

Suggested Antigen Peptide Sequences for OCM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the parvalbumin family.
  • Belongs to the parvalbumin family.
genes like me logo Genes that share domains with OCM2: view

Function for OCM2 Gene

Phenotypes From GWAS Catalog for OCM2 Gene

Gene Ontology (GO) - Molecular Function for OCM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 8354278
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OCM2: view
genes like me logo Genes that share phenotypes with OCM2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OCM2 Gene

Localization for OCM2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OCM2 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for OCM2 Gene

Pathways & Interactions for OCM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OCM2 Gene


No data available for Pathways by source and SIGNOR curated interactions for OCM2 Gene

Drugs & Compounds for OCM2 Gene

(4) Drugs for OCM2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for OCM2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OCM2: view

Transcripts for OCM2 Gene

mRNA/cDNA for OCM2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OCM2 Gene

Oncomodulin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OCM2 Gene

No ASD Table

Relevant External Links for OCM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OCM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OCM2 Gene

mRNA differential expression in normal tissues according to GTEx for OCM2 Gene

This gene is overexpressed in Brain - Amygdala (x8.2).

NURSA nuclear receptor signaling pathways regulating expression of OCM2 Gene:


SOURCE GeneReport for Unigene cluster for OCM2 Gene:

genes like me logo Genes that share expression patterns with OCM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OCM2 Gene

Orthologs for OCM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OCM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OCM2 33 34
  • 99.69 (n)
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
(Bos Taurus)
Mammalia -- 34
  • 96 (a)
(Mus musculus)
Mammalia Ocm 34
  • 90 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 78 (a)
(Gallus gallus)
Aves OCM 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53003 33
(Danio rerio)
Actinopterygii pvalb9 33 34
  • 61.77 (n)
pvalb8 34
  • 56 (a)
Species where no ortholog for OCM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OCM2 Gene

Gene Tree for OCM2 (if available)
Gene Tree for OCM2 (if available)

Paralogs for OCM2 Gene

Paralogs for OCM2 Gene

(9) SIMAP similar genes for OCM2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OCM2: view

Variants for OCM2 Gene

Sequence variations from dbSNP and Humsavar for OCM2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000349617 -- 97,984,943(+) TTCTC(C/T)AGAGA utr-variant-3-prime
rs1001241628 -- 97,989,399(+) TTTAT(G/T)TATTT intron-variant
rs1003530452 -- 97,988,308(+) AATGA(C/G)CAACA intron-variant
rs1007389807 -- 97,991,748(+) GGCTG(A/T)GGCCA upstream-variant-2KB
rs1007609165 -- 97,985,766(+) GAACC(A/C)AACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OCM2 Gene

Variant ID Type Subtype PubMed ID
nsv970555 CNV duplication 23825009
nsv428178 CNV gain 18775914
esv32764 CNV loss 17666407
esv2759546 CNV loss 17122850

Variation tolerance for OCM2 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OCM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OCM2 Gene

Disorders for OCM2 Gene

Relevant External Links for OCM2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OCM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OCM2 Gene

Publications for OCM2 Gene

  1. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 45 60
  2. Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs. (PMID: 15610002) Babini E … Quattrone A (Biochemistry 2004) 3 22 60
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60
  4. Calcium-binding proteins: distribution and implication in mammalian placenta. (PMID: 12583602) Belkacemi L … Lafond J (Endocrine 2002) 3 22 60
  5. The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings. (PMID: 8611623) Pauls TL … Berchtold MW (Biochimica et biophysica acta 1996) 3 22 60

Products for OCM2 Gene

Sources for OCM2 Gene

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