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Aliases for OCM2 Gene

Aliases for OCM2 Gene

  • Oncomodulin 2 2 3
  • Putative Oncomodulin-2 3
  • Parvalbumin Beta 3
  • OCMN 4
  • OCM 3
  • OM 3

External Ids for OCM2 Gene

Summaries for OCM2 Gene

Entrez Gene Summary for OCM2 Gene

  • This gene is similar to the oncomodulin gene, a high-affinity calcium ion-binding protein that belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for OCM2 Gene

OCM2 (Oncomodulin 2) is a Protein Coding gene. Diseases associated with OCM2 include benign paroxysmal positional nystagmus. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PVALB.

Gene Wiki entry for OCM2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OCM2 Gene

Genomics for OCM2 Gene

Genomic Location for OCM2 Gene

Start:
97,984,684 bp from pter
End:
97,991,169 bp from pter
Size:
6,486 bases
Orientation:
Minus strand

Genomic View for OCM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OCM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OCM2 Gene

Regulatory Elements for OCM2 Gene

Proteins for OCM2 Gene

  • Protein details for OCM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CE71-OCM2_HUMAN
    Recommended name:
    Putative oncomodulin-2
    Protein Accession:
    P0CE71
    Secondary Accessions:
    • P32930
    • Q6ISI5
    • Q75MW0

    Protein attributes for OCM2 Gene

    Size:
    109 amino acids
    Molecular mass:
    12129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OCM2 Gene

Proteomics data for OCM2 Gene at MOPED

Post-translational modifications for OCM2 Gene

No Post-translational modifications

Other Protein References for OCM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OCM2 Gene

Domains for OCM2 Gene

Gene Families for OCM2 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for OCM2 Gene

Suggested Antigen Peptide Sequences for OCM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CE71

UniProtKB/Swiss-Prot:

OCM2_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • P0CE71
Family:
  • Belongs to the parvalbumin family.:
    • P0CE71
genes like me logo Genes that share domains with OCM2: view

Function for OCM2 Gene

Gene Ontology (GO) - Molecular Function for OCM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 8354278
genes like me logo Genes that share ontologies with OCM2: view

Phenotypes for OCM2 Gene

genes like me logo Genes that share phenotypes with OCM2: view

Animal Models for OCM2 Gene

MGI Knock Outs for OCM2:
  • Ocm tm1.1Ddsi

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OCM2 Gene

Localization for OCM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OCM2 Gene COMPARTMENTS Subcellular localization image for OCM2 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OCM2 Gene

Pathways for OCM2 Gene

SuperPathways for OCM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OCM2 Gene

None

No data available for Pathways by source for OCM2 Gene

Compounds for OCM2 Gene

(8) Novoseek inferred chemical compound relationships for OCM2 Gene

Compound -log(P) Hits PubMed IDs
aspartate 43.1 3
calcium 35.8 13
allergens 33.7 1
carboxylate 29.9 1
magnesium 26 3
genes like me logo Genes that share compounds with OCM2: view

Transcripts for OCM2 Gene

mRNA/cDNA for OCM2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OCM2 Gene

Oncomodulin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OCM2 Gene

No ASD Table

Relevant External Links for OCM2 Gene

GeneLoc Exon Structure for
OCM2
ECgene alternative splicing isoforms for
OCM2

Expression for OCM2 Gene

mRNA expression in normal human tissues for OCM2 Gene

mRNA differential expression in normal tissues according to GTEx for OCM2 Gene

This gene is overexpressed in Brain - Amygdala (8.2).

SOURCE GeneReport for Unigene cluster for OCM2 Gene Hs.510456

genes like me logo Genes that share expressions with OCM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OCM2 Gene

Orthologs for OCM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OCM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OCM2 35
  • 99.69 (n)
  • 100 (a)
OCM2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ocm 16
Ocm 36
  • 90 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves OCM 36
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC53003 35
zebrafish
(Danio rerio)
Actinopterygii pvalb8 36
  • 56 (a)
ManyToMany
pvalb9 35
  • 61.77 (n)
  • 58.72 (a)
pvalb9 36
  • 54 (a)
ManyToMany
Species with no ortholog for OCM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OCM2 Gene

ENSEMBL:
Gene Tree for OCM2 (if available)
TreeFam:
Gene Tree for OCM2 (if available)

Paralogs for OCM2 Gene

Paralogs for OCM2 Gene

Selected SIMAP similar genes for OCM2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OCM2: view

Variants for OCM2 Gene

Sequence variations from dbSNP and Humsavar for OCM2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1859642 -- 97,991,975(-) CAACA(C/T)GGCAA upstream-variant-2KB
rs2894159 -- 97,986,856(+) CCGAG(A/C)ATTAT intron-variant
rs2894160 -- 97,990,407(+) AGAGA(C/T)GGGGT upstream-variant-2KB
rs3060405 -- 97,985,434(+) aaaaa(-/AGAAA)gaaag intron-variant
rs3757456 -- 97,990,156(+) CAGGA(A/C)CGTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OCM2 Gene

Variant ID Type Subtype PubMed ID
nsv428178 CNV Gain 18775914
dgv2118e1 CNV Complex 17122850
esv32764 CNV Loss 17666407

Relevant External Links for OCM2 Gene

HapMap Linkage Disequilibrium report
OCM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OCM2 Gene

Disorders for OCM2 Gene

(3) University of Copenhagen DISEASES for OCM2 Gene

(2) Novoseek inferred disease relationships for OCM2 Gene

Disease -log(P) Hits PubMed IDs
menieres disease 42.9 1
tumors 0 5

Relevant External Links for OCM2

Genetic Association Database (GAD)
OCM2
genes like me logo Genes that share disorders with OCM2: view

No data available for UniProtKB/Swiss-Prot for OCM2 Gene

Publications for OCM2 Gene

  1. The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome. (PMID: 1559707) Ritzler J.M. … Berchtold M.W. (Genomics 1992) 3 23
  2. Human alpha and beta parvalbumins. Structure and tissue-specific expression. (PMID: 8354278) Foehr U.G. … Heizmann C.W. (Eur. J. Biochem. 1993) 3 23
  3. The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings. (PMID: 8611623) Pauls T.L. … Berchtold M.W. (Biochim. Biophys. Acta 1996) 3 23
  4. Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs. (PMID: 15610002) Babini E. … Quattrone A. (Biochemistry 2004) 3 23
  5. Calcium-binding proteins: distribution and implication in mammalian placenta. (PMID: 12583602) Belkacemi L. … Lafond J. (Endocrine 2002) 3 23

Products for OCM2 Gene

Sources for OCM2 Gene

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