OCM2 Gene
protein-coding GIFtS: 46
GCID: GC07M097614
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|
oncomodulin 2
| |
Aliases
for OCM2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oncomodulin 21 2 | | OCM2 | | OM2 | | Parvalbumin Beta2 | | Putative Oncomodulin-22 | | OCMN3 |
Export aliases for OCM2 gene to outside databasesPrevious GC identifers: GC07M097454 GC07M092214 |
Summaries
for OCM2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OCM2:
This gene is similar to the oncomodulin gene, a high-affinity calcium ion-binding protein that belongs to thesuperfamily of calmodulin proteins, also known as the EF-hand proteins. (provided by RefSeq, Jul 2008)
Gene Wiki entry for OCM2 (LOC4951)
|
Genomic Views
for OCM2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OCM2 gene promoter:
TBP NF-1/L NF-1 RP58 RORalpha1 TFIID ATF6 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OCM2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCM2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.2 Ensembl cytogenetic band: 7q21.3 HGNC cytogenetic band: 7q21.2OCM2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M097614: view genomic region
(about GC identifiers)
Start:
|
97,613,996 bp from pter |
End:
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97,620,481 bp from pter |
Size:
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6,486 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 96,938,878-96,944,293 |
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Proteins
for OCM2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OCM2_HUMAN, P0CE71 (See
protein sequence)Recommended Name: Putative oncomodulin-2 Size: 109 amino acids; 12129 Da
Caution: Could be the product of a pseudogene
Secondary accessions: P32930 Q6ISI5 Q75MW0Explore the universe of human proteins at neXtProt for OCM2: NX_P0CE71
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0CE71
OCM2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006179.2
ENSEMBL proteins: ENSP00000257627
Human Recombinant Protein Products:
OCM2 Antibody Products:
Assay Products for OCM2: |
Protein
Domains /
Families
for OCM2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OCM2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0CE71ProtoNet protein and cluster: P0CE71 UniProtKB/Swiss-Prot: OCM2_HUMAN, P0CE71Similarity: Belongs to the parvalbumin familySimilarity: Contains 2 EF-hand domains |
Function
for OCM2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCM2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCM2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OCM2 (NM_006188) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OCM2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCM2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCM2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
OCM2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ocmtm1.1Ddsi for OCM2
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ocm):
OCM2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for OCM2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OCM2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for OCM2 (P0CE713 ENSP000002576274) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for OCM2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
OCM2 for compounds About GeneDecksing
 Browse Tocris compounds for OCM2
8 Novoseek chemical compound relationships for OCM2 gene About this table
Search CenterWatch for drugs/clinical trials and news about OCM2
|
Transcripts
for OCM2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OCM2 gene: NM_006188.3 Unigene Cluster for OCM2: Oncomodulin 2 Hs.510456 [show with all ESTs]Unigene Representative Sequence: NM_0061882 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000257627(uc003upc.3) ENST00000473987
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCM2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCM2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OCM2 (NM_006188) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OCM2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCM2 |
2 DOTS entries: DT.121050231 DT.99950112 4 AceView cDNA sequences: BC069468 BC069512 BC069550 NM_006188
GeneLoc Exon Structure
|
Expression
for OCM2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OCM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTTCTTGG
About this image
See OCM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OCM2
SOURCE GeneReport for Unigene cluster: Hs.510456
SABiosciences Custom PCR Arrays for OCM2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OCM2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OCM2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCM2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCM2 |
Orthologs
for OCM2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OCM2 gene from 4/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PRVU_CHICK6 |
Parvalbumin, thymic CPV3 |
70(a) |
1 → many |
14(1020597-1023986) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
68(a) |
1 → many |
GL343507.1(332855-339273) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC530032 |
similar to Parvalbumin (calcium binding protein) |
72.59(n) |
|
BC041508.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AF467915.12 |
-- |
73(n) |
|
AF467915.1 |
ENSEMBL Gene Tree for OCM2 (if available)
TreeFam Gene Tree for OCM2 (if available) |
Paralogs
for OCM2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OCM2 gene
- PVALB2 OCM2
9 SIMAP similar genes for OCM2 using alignment to 1 protein entry: OCM2_HUMAN:OCM PVALB TNNC1 CALML3 TNNC2 CALM1
CALM2 CALM3 CALML6
OCM2 for paralogs About GeneDecksing
|
Genomic Variants
for OCM2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OCM2 (97613996 - 97620481 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for OCM2
2 CNVs: 3691 7657 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OCM2 |
|
Disorders
/ Diseases
for OCM2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OCM2 for disorders About GeneDecksing
9  diseases for OCM2: About MalaCardsbenign paroxysmal positional nystagmus meniere's disease menieres disease duodenum adenocarcinoma
peptic ulcer dyspepsia nystagmus colorectal cancer
adenoma
3 diseases from the University of Copenhagen DISEASES database for OCM2:Peptic ulcer Dyspepsia Benign paroxysmal positional nystagmus 2 Novoseek disease relationships for OCM2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| menieres disease |
42.9 |
1 |
11790893 (1) |
| tumors |
0 |
5 |
2194456 (4), 11245467 (1) |
Export disorders for OCM2 gene to outside databases
|
Publications
for OCM2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OCM2 gene, integrated from 9 sources (see all 66):
(articles sorted by number of sources associating them with OCM2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Human alpha and beta parvalbumins. Structure and tissue-specific expression. (PubMed id 8354278)1, 9 Foehr U.G.... Heizmann C.W. (1993)
- Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs. (PubMed id 15610002)1, 9 Babini E.... Quattrone A. (2004)
- The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings. (PubMed id 8611623)1, 9 Pauls T.L....Berchtold M.W. (1996)
- Calcium-binding proteins: distribution and implication in mammalian placenta. (PubMed id 12583602)1, 9 Belkacemi L....Lafond J. (2002)
- The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome. (PubMed id 1559707)1, 9 Ritzler J.M....Berchtold M.W. (1992)
- GWAS for discovery and replication of genetic loci as sociated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1 Aouizerat B.E....Tseng Z.H. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
|
External Searches for OCM2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OCM2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OCM2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OCM2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OCM2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OCM2 gene:
Search GeneIP for patents involving OCM2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OCM2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for OCM2 | | OriGene shRNA RFP for OCM2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OCM2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OCM2 | | | OriGene Protein Over-expression Lysate for OCM2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OCM2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCM2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCM2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for OCM2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OCM2 | | OriGene Custom Protein Services for OCM2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OCM2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OCM2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCM2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OCM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCM2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCM2 |
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| | | | Search Tocris compounds for OCM2 |
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 | | | OCM2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCM2 |
|  |  |  | | | | Search ThermoFisher Antibodies for OCM2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCM2 |
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