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Aliases for OCM Gene

Aliases for OCM Gene

  • Oncomodulin 2 3
  • Parvalbumin Beta 3 4
  • Oncomodulin 1 2 3
  • OCM1 3 4
  • OM 3 4
  • Oncomodulin-1 3
  • HCG18255 3
  • OCMN 4
  • ONCM 3

External Ids for OCM Gene

Previous GeneCards Identifiers for OCM Gene

  • GC07M096148
  • GC07M097211
  • GC07M097225
  • GC07M097258
  • GC07M097452

Summaries for OCM Gene

Entrez Gene Summary for OCM Gene

  • Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for OCM Gene

OCM (Oncomodulin) is a Protein Coding gene. Diseases associated with OCM include benign paroxysmal positional nystagmus. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PVALB.

UniProtKB/Swiss-Prot for OCM Gene

  • Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OCM Gene

Genomics for OCM Gene

Regulatory Elements for OCM Gene

Genomic Location for OCM Gene

5,879,827 bp from pter
5,886,363 bp from pter
6,537 bases
Plus strand

Genomic View for OCM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OCM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OCM Gene

Proteins for OCM Gene

  • Protein details for OCM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B9EJH7
    • P32930
    • Q6ISI5
    • Q75MW0

    Protein attributes for OCM Gene

    109 amino acids
    Molecular mass:
    12184 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OCM Gene

neXtProt entry for OCM Gene

Proteomics data for OCM Gene at MOPED

Post-translational modifications for OCM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OCM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OCM

No data available for DME Specific Peptides for OCM Gene

Domains for OCM Gene

Gene Families for OCM Gene

  • EFHAND :EF-hand domain containing

Protein Domains for OCM Gene

Suggested Antigen Peptide Sequences for OCM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P0CE72
  • Contains 2 EF-hand domains.
  • Belongs to the parvalbumin family.
genes like me logo Genes that share domains with OCM: view

Function for OCM Gene

Molecular function for OCM Gene

GENATLAS Biochemistry:
oncomodulin,expressed in embryonal cells,placenta,tumors
UniProtKB/Swiss-Prot Function:
Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions

Gene Ontology (GO) - Molecular Function for OCM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 8354278
genes like me logo Genes that share ontologies with OCM: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OCM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OCM Gene

Localization for OCM Gene

Subcellular locations from

Jensen Localization Image for OCM Gene COMPARTMENTS Subcellular localization image for OCM gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OCM Gene

Pathways for OCM Gene

SuperPathways for OCM Gene

No Data Available

Interacting Proteins for OCM Gene

Gene Ontology (GO) - Biological Process for OCM Gene


No data available for Pathways by source for OCM Gene

Transcripts for OCM Gene

mRNA/cDNA for OCM Gene

(7) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OCM Gene

Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OCM

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OCM Gene

No ASD Table

Relevant External Links for OCM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OCM Gene

mRNA expression in normal human tissues for OCM Gene

mRNA differential expression in normal tissues according to GTEx for OCM Gene

This gene is overexpressed in Brain - Amygdala (11.3).

SOURCE GeneReport for Unigene cluster for OCM Gene Hs.571315

genes like me logo Genes that share expressions with OCM: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OCM Gene

Orthologs for OCM Gene

This gene was present in the common ancestor of chordates.

Orthologs for OCM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100301381 35
  • 90.74 (n)
  • 96.67 (a)
-- 36
  • 95 (a)
(Canis familiaris)
Mammalia LOC489870 35
  • 90.21 (n)
  • 97.25 (a)
-- 36
  • 97 (a)
(Mus musculus)
Mammalia Ocm 35
  • 86.85 (n)
  • 88.07 (a)
Ocm 36
  • 88 (a)
(Pan troglodytes)
Mammalia OCM 35
  • 99.08 (n)
  • 99.08 (a)
OCM 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ocm2 35
  • 86.85 (n)
  • 88.99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
(Gallus gallus)
Aves OCM 35
  • 69.72 (n)
  • 67.89 (a)
OCM 36
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485867 35
  • 67.58 (n)
  • 64.22 (a)
(Danio rerio)
Actinopterygii pvalb8 35
  • 62.39 (n)
  • 59.63 (a)
pvalb8 36
  • 56 (a)
pvalb9 36
  • 54 (a)
Species with no ortholog for OCM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OCM Gene

Gene Tree for OCM (if available)
Gene Tree for OCM (if available)

Paralogs for OCM Gene

Paralogs for OCM Gene

Selected SIMAP similar genes for OCM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OCM: view

Variants for OCM Gene

Sequence variations from dbSNP and Humsavar for OCM Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1971651 -- 5,882,180(+) TTAGA(A/C)CAGGG intron-variant
rs2108071 -- 5,885,591(+) CAGGG(A/T)TTTTT intron-variant
rs2345660 -- 5,885,736(-) CTACT(C/T)GGGAG intron-variant
rs2881189 -- 5,885,525(-) CTTAT(C/T)TAACA intron-variant
rs3890913 -- 5,884,107(+) CTTAA(A/C)CTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OCM Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv887420 CNV Gain 21882294
dgv402n21 CNV Loss 19592680
nsv830892 CNV Loss 17160897
dgv7145n71 CNV Loss 21882294
nsv830894 CNV Loss 17160897

Relevant External Links for OCM Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OCM Gene

Disorders for OCM Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for OCM Gene in MalaCards »

(1) Diseases for OCM Gene including...

(3) University of Copenhagen DISEASES for OCM Gene

genes like me logo Genes that share disorders with OCM: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for OCM Gene

Publications for OCM Gene

  1. Human alpha and beta parvalbumins. Structure and tissue-specific expression. (PMID: 8354278) Foehr U.G. … Heizmann C.W. (Eur. J. Biochem. 1993) 2 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome. (PMID: 1559707) Ritzler J.M. … Berchtold M.W. (Genomics 1992) 2 3
  4. Inhibition of glutathione reductase by oncomodulin. (PMID: 2306116) Palmer E.J. … Mutus B. (Arch. Biochem. Biophys. 1990) 3
  5. Disulfide-linked dimer of oncomodulin: comparison to calmodulin. (PMID: 3179268) Mutus B. … MacManus J.P. (Biochemistry 1988) 3

Products for OCM Gene

Sources for OCM Gene

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