OCM Gene
protein-coding GIFtS: 43
GCID: GC07P005891
|
|
oncomodulin
| |
Aliases
for OCM gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oncomodulin1 | | HCG182551 | | OCM11 2 3 | | Oncomodulin 12 | | Parvalbumin Beta2 3 | | Oncomodulin-11 | | OM2 3 | | OCMN3 | | ONCM2 | | |
Export aliases for OCM gene to outside databasesPrevious GC identifers: GC07M096148 GC07M097211 GC07M097225 GC07M097258 GC07M097452 |
Summaries
for OCM gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OCM:
Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, alsoknown as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in theplacenta and also in tumors. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ONCO_HUMAN, P0CE72Function: Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calciumions
|
Genomic Views
for OCM gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OCM gene promoter:
RORalpha1 TBP RP58 p53 TFIID STAT3 IRF-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for OCM
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCM |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.1 Ensembl cytogenetic band: 7p22.1 HGNC cytogenetic band: 7p22.1OCM Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P005891: view genomic region
(about GC identifiers)
Start:
|
5,919,458 bp from pter |
End:
|
5,925,994 bp from pter |
Size:
|
6,537 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 5,966,774-5,972,339 |
|
Proteins
for OCM gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ONCO_HUMAN, P0CE72 (See
protein sequence)Recommended Name: Oncomodulin-1 Size: 109 amino acids; 12184 Da
1 PDB 3D structure from  and Proteopedia  for OCM:1TTX (3D)
Secondary accessions: B9EJH7 P32930 Q6ISI5 Q75MW0Explore the universe of human proteins at neXtProt for OCM: NX_P0CE72
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0CE72
OCM Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001091091.1
ENSEMBL proteins: ENSP00000401365 ENSP00000242104
Human Recombinant Protein Products for OCM:
OCM Antibody Products:
Assay Products for OCM: |
Protein
Domains /
Families
for OCM gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OCM for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0CE72ProtoNet protein and cluster: P0CE72 UniProtKB/Swiss-Prot: ONCO_HUMAN, P0CE72Similarity: Belongs to the parvalbumin familySimilarity: Contains 2 EF-hand domains |
Function
for OCM gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ONCO_HUMAN, P0CE72Function: Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calciumions Genatlas biochemistry entry for OCM:oncomodulin,expressed in embryonal cells,placenta,tumors
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
OCM for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCM
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCM
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OCM (NM_006188) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OCM | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCM |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCM |
|
Pathways & Interactions
for OCM gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OCM
|
Drugs & Compounds
for OCM gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OCM
Search CenterWatch for drugs/clinical trials and news about OCM / ONCO
|
Transcripts
for OCM gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OCM gene: NM_001097622.1 Unigene Cluster for OCM: Oncomodulin Hs.571315 [show with all ESTs]Unigene Representative Sequence: NM_0010976222 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000416608 ENST00000242104(uc003spe.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCM
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCM
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OCM (NM_006188) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OCM | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCM |
Additional cDNA sequence: BC069468.1 BC069512.1 BC069550.1 BC113704.1 BC113706.1 BC147028.1 BC147029.1 2 DOTS entries: DT.40111788 DT.99950112
GeneLoc Exon Structure
|
Expression
for OCM gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OCM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OCM Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.571315
SABiosciences Custom PCR Arrays for OCM
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OCM
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat OCM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCM | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCM |
Orthologs
for OCM gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OCM gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for OCM (if available)
TreeFam Gene Tree for OCM (if available) |
Paralogs
for OCM gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OCM gene
- OCM22 PVALB2
8 SIMAP similar genes for OCM using alignment to 1 protein entry: ONCO_HUMAN:OCM2 PVALB TNNC1 CALML3 TNNC2 CALM1
CALM2 CALM3
OCM for paralogs About GeneDecksing
|
Genomic Variants
for OCM gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OCM (5919458 - 5925994 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 0 variation for OCM | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for OCM gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OCM for disorders About GeneDecksing
OMIM gene information: 164795
OMIM disorders: --
6  diseases for OCM: About MalaCardsbenign paroxysmal positional nystagmus peptic ulcer meniere's disease menieres disease
dyspepsia nystagmus
3 diseases from the University of Copenhagen DISEASES database for OCM:Peptic ulcer Dyspepsia Benign paroxysmal positional nystagmus Export disorders for OCM gene to outside databases
|
Publications
for OCM gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OCM gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with OCM) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human alpha and beta parvalbumins. Structure and tissue-specific expression. (PubMed id 8354278)1, 2, 3 Foehr U.G.... Heizmann C.W. (1993)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome. (PubMed id 1559707)1, 3 Ritzler J.M....Berchtold M.W. (1992)
- Novel autosomal recessive nonsyndromic hearing impair ment locus DFNB90 maps to 7p22.1-p15.3. (PubMed id 21734401)1 Ali G....Leal S.M. (2011)
- Long-distance axon regeneration in the mature optic n erve: contributions of oncomodulin, cAMP, and pten gene deletion. (PubMed id 21084621)1 Kurimoto T....Benowitz L.I. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs. (PubMed id 15610002)2 Babini E.... Quattrone A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
|
External Searches for OCM gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OCM gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OCM gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OCM gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for OCM gene:
Search GeneIP for patents involving OCM
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OCM gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OCM | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OCM | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OCM | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OCM | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCM | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCM | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OCM | | OriGene Custom Protein Services for OCM | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OCM | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OCM | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCM | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OCM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCM |
| |
 |  |  |  | |
| | | | Search Tocris compounds for OCM |
| |  |  |  |  | | | | | | Recombinant Protein for OCM |
|
 |
 |
 |
 | | | OCM Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCM |
|  |  |  |  | | | | Search ThermoFisher Antibodies for OCM |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCM |
| |  | |
|
|
|
