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OCM Gene

protein-coding GIFtS: 43

GC07P005891

oncomodulin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC142264 ^²
MGC142266 ^²
MGC97453 ^²
MGC97465 ^²
MGC97477 ^²
OCM1 ^¹, ²
OCMN ^³
OM ^², ³
ONCM ^²
hCG18255 ^²
oncomodulin ^²

Descriptions
Parvalbumin beta ^³
oncomodulin 1 ^²

External Ids
HGNC: 8105¹
Entrez Gene: 654231²
UniProtKB: P32930³
Ensembl: ENSG00000122543⁷

Search outside databases for aliases for OCM gene

Previous GC identifers: GC07M096148 GC07M097211 GC07M097225 GC07M097258 GC07M097452

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for OCM:

Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of

calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental

protein found in early embryonic cells in the placenta and also in tumors. [provided by RefSeq]

UniProtKB/Swiss-Prot: ONCO_HUMAN, P32930

Function: Has some calmodulin-like activity with respect to enzyme activation and growth

regulation. Binds two calcium ions

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OCM gene

Entrez Gene cytogenetic band: 7p22.1 Ensembl cytogenetic band: 7p22.1 HGNC cytogenetic band: 7p22.1

OCM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P005891: (about GC identifiers)

Start:	5,886,955 bp from pter
End:	5,892,520 bp from pter
Size:	5,566 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 5,966,774-5,972,339

RefSeq DNA sequence:

NC_000007.12 NT_007819.16 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ONCO_HUMAN, P32930 (See protein sequence)

Recommended Name: Oncomodulin

Size: 109 amino acids; 12156 Da

PDB structures from and Proteopedia :

1TTX (3D)

Secondary accessions: Q6ISI5 Q75MW0

REFSEQ proteins: NP_001091091.1

ENSEMBL proteins:

ENSP00000242104

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (oncomodulin)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

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Antibodies for OCM:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (oncomodulin), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OCM

Assays for OCM:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P32930

ProtoNet protein and cluster: P32930

1 Blocks protein family: IPB008080 Parvalbumin signature

UniProtKB/Swiss-Prot: ONCO_HUMAN, P32930

Similarity: Belongs to the parvalbumin family

Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Applied Biosystems Silencer® siRNAs for OCM

Sigma-Aldrich siRNA for OCM

Sigma-Aldrich shRNA for OCM

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OCM
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001097622
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001097622
untagged cDNA clone in CMV expression vector: NM_001097622

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001097622

UniProtKB/Swiss-Prot: ONCO_HUMAN, P32930

Function: Has some calmodulin-like activity with respect to enzyme activation and growth

regulation. Binds two calcium ions

Genatlas biochemistry entry for OCM:

oncomodulin,expressed in embryonal cells,placenta,tumors

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	NAS	8354278

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Interacting proteins for OCM (ENSP00000242104³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BOC	ENSP00000273395³	STRING (score=.926)
CACNA1A	ENSP00000353362³	STRING (score=.84)
VDAC1	ENSP00000265333³	STRING (score=.75)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OCM

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Sigma-Aldrich siRNA for OCM

Sigma-Aldrich shRNA for OCM

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001097622

REFSEQ mRNAs for OCM gene:

NM_001097622.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001097622

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001097622
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001097622
                                 untagged cDNA clone in CMV expression vector: NM_001097622

Additional cDNA sequence:

BC069468.1 BC069512.1 BC069550.1 BC113704.1 BC113706.1 BC147028.1 BC147029.1

2 DOTS entries:

DT.40111788 DT.99950112

highest scoring ESTs for OCM:

BG193011 BG201195 BG201703 BG211115 NM_006188 L20348 XM_379777 BC069468 BC069512 BC069550

Unigene Cluster for OCM:

Oncomodulin

Hs.571315 [show with all ESTs]

Unigene Representative Sequence: NM_001097622

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000242104

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OCM expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OCM

¹ / ² / ³

2 probe-sets matching OCM gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
207944_at²^{, 3}	U133-A	2	0.91	0.50	--	--	NM_006188	0.60	1.00	0.82	1
207944_at²	U133Plus2	2	0.91	0.50	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.571315
Expression variation in blood from EXPOLDB for OCM

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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ENSEMBL Gene Tree for OCM

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for OCM gene

OCM2² PVALB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/95 NCBI SNPs in OCM are shown (see all 95 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 4)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12668032^1,2	C,F,H	5885566(+)	`GCCGGG/CTGAGA`	1	--	ng5¹		4		EU EA WA	412
--	rs10235465^1,2	C	5886932(+)	`aaaaaA/TaaTCT`	1	--	ng5¹ tfbs³		0	--	--	--	--
	rs11981221^1,2	H	5885824(+)	`GAAATC/TTTAGT`	1	--	ng5¹		4		EU EA WA	418
--	rs2881189^1,2	A,C,F,H	5891682(-)	`CTTATT/CTAACA`	1	--	int¹		9		NS EU EA WA	516
	rs2108071^1,2	A,F,H	5891748(+)	`CAGGGT/ATTTTT`	1	--	int¹ trp³		3		EA WA	290
--	rs7798766^1,2	C,F,H	5890208(+)	`CATCCG/CTGAGG`	1	--	int¹		4		EU EA WA	378
--	rs3890913^1,2	A,F,H	5890264(+)	`CTTAAC/ACTTAC`	1	--	int¹		4		EU EA WA	416
--	rs4343990^1,2	A,C	5891958(+)	`agacaC/Gggttt`	1	--	int¹		0	--	--	--	--
--	rs1971651^1,2	C,F	5888337(+)	`TTAGAA/CCAGGG`	1	--	int¹		7		NA EA MN	562
--	rs2345660^1,2	A,C	5891893(-)	`ctactC/Tgggag`	1	--	int¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for OCM (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164795

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for OCM gene:

Human alpha and beta parvalbumins. Structure and tissue-specific expression. (PubMed id 8354278)^{2, 3, 4} Fohr U.G....Heizmann C.W. (1993)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome. (PubMed id 1559707)^{2, 3} Ritzler J.M....Berchtold M.W. (1992)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs. (PubMed id 15610002)⁴ Babini E.... Quattrone A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
The sequence of the human genome. (PubMed id 11181995)³ Venter J.C....Zhu X. (2001)
The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings. (PubMed id 8611623)³ Pauls T.L....Berchtold M.W. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 654231	HGNC: 8105	Ensembl:ENSG00000122543	euGenes: HUgn654231	ECgene: OCM
H-InvDB: OCM

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for OCM	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for OCM
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OCM:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OCM-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OCM		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OCM		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (oncomodulin)
	Antibodies (oncomodulin)

Search OriGene for OCM

Search Tocris compounds for OCM

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for OCM

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OCM Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for OCM

Summaries
for OCM

Genomic Location
for OCM

Proteins
for OCM

Protein Domains/
Families
for OCM

Gene Function
for OCM

Pathways & Interactions
for OCM

Drugs & Compounds
for OCM

Transcripts
for OCM

Expression
for OCM

Orthologs
for OCM

Paralogs
for OCM

SNPs/Variants
for OCM

Disorders & Mutations
for OCM

Medical News
for OCM

Publications
for OCM

Search for OCM

Genome Databases showing OCM

Other Databases showing OCM

Specialized Databases showing OCM

Licensable Technologies
for OCM

Services
for OCM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OCM Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor OCM

Summariesfor OCM

Genomic Locationfor OCM

Proteinsfor OCM

Protein Domains/Familiesfor OCM

Gene Functionfor OCM

Pathways & Interactionsfor OCM

Drugs & Compoundsfor OCM

Transcriptsfor OCM

Expression for OCM

Orthologsfor OCM

Paralogsfor OCM

SNPs/Variantsfor OCM

Disorders & Mutationsfor OCM

Medical Newsfor OCM

Publicationsfor OCM

Search for OCM

Genome Databases showing OCM

Other Databases showing OCM

Specialized Databases showing OCM

Licensable Technologiesfor OCM

Servicesfor OCM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OCM

Summaries
for OCM

Genomic Location
for OCM

Proteins
for OCM

Protein Domains/
Families
for OCM

Gene Function
for OCM

Pathways & Interactions
for OCM

Drugs & Compounds
for OCM

Transcripts
for OCM

Expression
for OCM

Orthologs
for OCM

Paralogs
for OCM

SNPs/Variants
for OCM

Disorders & Mutations
for OCM

Medical News
for OCM

Publications
for OCM

Licensable Technologies
for OCM

Services
for OCM