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OCLN Gene

protein-coding GIFtS: 60

GC05P068823

occludin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
occludin ^²

Descriptions
tight junction protein occludin TM4 minus ^²

External Ids
HGNC: 8104¹
Entrez Gene: 4950²
UniProtKB: Q16625³
Ensembl: ENSG00000197822⁷

Search outside databases for aliases for OCLN gene

Previous GC identifers: GC05P068940 GC05P070353 GC05P068803

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OCLN:

This gene encodes an integral membrane protein which is located at tight junctions. This protein

may be involved in the formation and maintenance of the tight junction. The possibility of several

alternatively spliced products has been suggested but the full nature of these products has not

been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: OCLN_HUMAN, Q16625

Function: May play a role in the formation and regulation of the tight junction (TJ) paracellular

permeability barrier. It is able to induce adhesion when expressed in cells lacking tight

junctions

Gene Wiki entry for OCLN (Occludin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OCLN gene

Entrez Gene cytogenetic band: 5q13.1 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q13.1

OCLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P068823: (about GC identifiers)

Start:	68,823,875 bp from pter
End:	68,885,889 bp from pter
Size:	62,015 bases
Orientation:	plus strand

1 alternative location:

Chr5+,c5_H2 69,247,952-69,310,012

RefSeq DNA sequence:

NC_000005.8 NT_006713.14 NT_113801.1

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OCLN_HUMAN, Q16625 (See protein sequence)

Recommended Name: Occludin

Size: 522 amino acids; 59144 Da

Subunit: Interacts with TJP1/ZO1 and with VAPA

Subcellular location: Membrane; Multi-pass membrane protein. Cell junction, tight junction

PDB structure from and Proteopedia :

1WPA (3D)

1XAW (3D)

Secondary accessions: B5BU70 Q8N6K1

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002529.1

ENSEMBL proteins:

ENSP00000370143 ENSP00000347379 ENSP00000379719

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Occludin)
	Human Recombinant Proteins from Abnova (OCLN)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IEA	--
GO:0005886	plasma membrane	TAS	8601611
GO:0005923	tight junction	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0030054	cell junction	IEA	--

About this table

Antibodies for OCLN:

	Invitrogen Antibodies for OCLN
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for OCLN
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Occludin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (OCLN)
	Novus Biologicals Antibodies for OCLN

Assays for OCLN:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q16625

ProtoNet protein and cluster: Q16625

3 Blocks protein families:

IPB002958 Occludin signature

IPB008253 Marvel

IPB010844 Occludin and RNA polymerase II elongation factor ELL

UniProtKB/Swiss-Prot: OCLN_HUMAN, Q16625

Domain: The C-terminal is cytoplasmic and is important for interaction with ZO-1. Sufficient for

the tight junction localization. Involved in the regulation of the permeability barrier function

of the tight junction (By similarity). The first extracellular loop participates in an adhesive

interaction

Similarity: Belongs to the ELL/occludin family

Similarity: Contains 1 MARVEL domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OCLN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OCLN)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002538

Applied Biosystems Silencer® siRNAs for OCLN

Sigma-Aldrich siRNA and siRNA Panels for OCLN

Sigma-Aldrich shRNA for OCLN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OCLN
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002538
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002538
untagged cDNA clones in CMV expression vector (see all 2): NM_002538

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002538

UniProtKB/Swiss-Prot: OCLN_HUMAN, Q16625

Function: May play a role in the formation and regulation of the tight junction (TJ) paracellular

permeability barrier. It is able to induce adhesion when expressed in cells lacking tight

junctions

Genatlas biochemistry entry for OCLN:

occludin,60kDa,integral membrane at tight junctions of epithelial cells,highly expressed in

testis,kidney,liver,lung,brain,involved in the barrier and fence function of TJ,accessory protein

in TJ strands formation

11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ocln):

behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size	homeostasis/metabolism
immune system	limbs/digits/tail	muscle	nervous system	reproductive system
skeleton

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008119	thiopurine S-methyltransferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for OCLN (Your Favorite Gene powered by Ingenuity)

Tight Junction Signaling

GeneDecks OCLN for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for OCLN

5/55 Interacting proteins for OCLN (Q16625² ENSP00000347379³) via UniProtKB, MINT, and/or STRING (see all 55 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CSNK1E	P49674²	MINT-1892115 MINT-1892205 MINT-1892281 MINT-1892254 MINT-1892301 MINT-1892321
CSNK1A1	P48729²	MINT-1892232
SNW1	Q13573²	MINT-1892144
ULK1	O75385²	MINT-1892167
TJP1	ENSP00000281537³	STRING (score=.999)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	TAS	10749869
GO:0046498	S-adenosylhomocysteine metabolic process	IEA	--
GO:0046500	S-adenosylmethionine metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OCLN
10/28 Novoseek chemical compound relationships for OCLN gene (see all 28 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dextran	60.07	1	11920682 (1)
inulin	50.91	7	12547828 (3), 17991733 (2), 14500730 (1), 17298946 (1)
phalloidin	39.11	2	18587491 (1), 10075198 (1)
pd 98,059	32.41	3	12839332 (1), 15622522 (1), 9614120 (1)
threonine	25.97	15	10954417 (3), 19114660 (2), 17245419 (2), 17574235 (1) (see all 6)
tyrosine	25.41	25	12604349 (4), 10330056 (2), 15718285 (2), 14500730 (1) (see all 14)
calcium	14.08	20	16257565 (3), 17371936 (1), 16525024 (1), 17374535 (1) (see all 12)
phosphatidylinositol	8.62	2	10887180 (1), 14500730 (1)
guanylate	5.50	1	14522829 (1)
atp	0.00	7	10330056 (4), 11713100 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OCLN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OCLN)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002538

Sigma-Aldrich siRNA and siRNA Panels for OCLN

Sigma-Aldrich shRNA for OCLN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002538

REFSEQ mRNAs for OCLN gene:

NM_002538.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002538

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002538
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002538
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002538

Additional cDNA sequence:

AB451306.1 AB451437.1 AK290697.1 AK311037.1 AK313501.1 BC029886.1 CR606900.1 U49184.1

U53823.1 Z70716.1

5 DOTS entries:

DT.456071 DT.100741549 DT.40118471 DT.120845253 DT.100018590

24/128 AceView cDNA sequences (see all 128 ):

AW973523 AA579714 AW594204 AA904737 BI821285 AA385147 AA115379 BM021328

BX100815 BF002218 NM_002538 AW769000 AI922007 U49184 BF195894 BC029886

AU077103 AI949253 AU100203 BM782571 AI393262 AI862167 BE502010 BM971357

highest scoring ESTs for OCLN:

U49184 AA115379 AA564219 AA579714 AA904737 AI245771 AI564139 AI830322 AI862167 AL573780

Unigene Cluster for OCLN:

Occludin

Hs.592605 [show with all ESTs]

Unigene Representative Sequence: NM_002538

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for OCLN

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10
SP1:
SP2:									-
SP3:
SP4:			-		-		-		-
SP5:							-		-

About this scheme

ECgene alternative splicing isoforms for OCLN

3 Ensembl transcripts including schematic representations:

ENST00000380766 ENST00000355237 ENST00000396442

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OCLN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OCLN

¹ / ² / ³

3 probe-sets matching OCLN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38524_at²^{, 3}	U95-A	2	0.94	0.60	1.00	1.00	U49184	1.00	0.90	0.95	1
209925_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U53823	0.80	1.00	0.91	1
209925_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks OCLN for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAAAGTAAA

SOURCE GeneReport for Unigene cluster: Hs.592605
UniProtKB/Swiss-Prot: OCLN_HUMAN, Q16625
Tissue specificity: Localized at tight junctions of both epithelial and endothelial cells. Highly
expressed in kidney. Not detected in testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OCLN gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OCLN¹	--	occludin	87.97(n) 91.36(a)	403844 NM_001003195.1 NP_001003195.1
chimpanzee (Pan troglodytes)	OCLN¹	--	occludin	99.55(n) 99.81(a)	741925 XM_001158288.1 XP_001158288.1
cow (Bos taurus)	OCLN¹	--	occludin	88.42(n) 90.98(a)	512405 XM_590937.3 XP_590937.3
rat (Rattus norvegicus)	Ocln¹	--	occludin	85.03(n) 89.25(a)	83497 NM_031329.2 NP_112619.2
mouse (Mus musculus)	Ocln^{1, 5}	13 (55.90 cM)⁵	occludin^{1, 5}	86.68(n)¹ 90.93(a)¹	18260¹ NM_008756.2¹ NP_032782.1¹ AI503564⁵ AK019880⁵ (see all 13)

About this table Species with no ortholog for OCLN

ENSEMBL Gene Tree for OCLN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/126 NCBI SNPs in OCLN are shown (see all 126 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 14)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs3733742^1,2	C,F,H	68824017(+)	`GCAACG/ATCGCG`	1	--	ut5¹ ese³		4		EU EA WA	414
--	rs28652974^1,2	C	68826196(+)	`TAGGGG/TCCTCC`	1	--	int¹		0	--	--	--	--
--	rs35628909^1,2	F	68860642(+)	`GAGAGA/GAGATT`	1	--	int¹		1		EA	90
--	rs28703202^1,2	C	68862544(+)	`CTTTGA/GAGACT`	1	--	int¹		0	--	--	--	--
--	rs28529133^1,2	C	68864052(+)	`GAAATA/GTCTGT`	1	--	int¹		0	--	--	--	--
	rs28666036^1,2	--	68822536(+)	`TTGGGG/TGCGAT`	1	--	ng5¹ tfbs³		0	--	--	--	--
--	rs61417711^1,2	--	68823385(+)	`AAAAA-/AAGTAAA`	1	--	ng5¹		0	--	--	--	--
	rs28562785^1,2	--	68841125(+)	`CATTGC/TCGCGT`	1	A/V	mis¹ ese³		0	--	--	--	--
--	rs17852716^1,2	--	68841371(+)	`GTATTC/TGTATC`	1	L/S	mis¹ ese³		0	--	--	--	--
--	rs34768268^1,2	--	68823377(+)	`TAAAA-/AAAAAAA`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for OCLN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602876

10/26 Novoseek disease relationships for OCLN gene (see all 26 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diabetic retinopathy	32.11	2	9836530 (1), 16446700 (1)
brain edema	30.77	1	19066093 (1)
inflammatory bowel diseases	29.81	1	15702229 (1)
inflammation	28.01	1	16505137 (1)
colitis	22.99	2	18711353 (1), 9952110 (1)
edema	18.31	5	16786176 (2), 10400043 (2)
cerebral ischemia	15.77	1	16973272 (1)
tumors	13.78	23	10806119 (2), 10965803 (2), 11920682 (2), 16982755 (1) (see all 13)
urticaria	11.53	3	16478881 (1), 18187566 (1), 10595922 (1)
adenocarcinoma	8.92	8	9212730 (2), 11679090 (2), 15232740 (1), 19390931 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/426 PubMed articles for OCLN gene (see all 426 ):

Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. (PubMed id 8601611)^{1, 2, 3, 4} Ando-Akatsuka Y.... Tsukita S. (1996)
Occludin confers adhesiveness when expressed in fibroblasts. (PubMed id 9175707)^{1, 3, 4} Van Itallie C.M. and Anderson J.M. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. (PubMed id 19017651)^{1, 3} Elias B.C....Rao R. (2009)
Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation. (PubMed id 15472219)^{1, 3} Zeng R....Gorodeski G.I. (2004)
Expression of occludin, tight-junction-associated protein, in human digestive tract. (PubMed id 9212730)^{1, 3} Kimura Y....Monden M. (1997)
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. (PubMed id 19182773)^{1, 3} Ploss A....Rice C.M. (2009)
A protein kinase A-dependent mechanism by which rotavirus affects the distribution and mRNA level of the functional tight junction-associated protein, occludin, in human differentiated intestinal Caco-2 cells. (PubMed id 17553883)^{1, 3} Beau I....Servin A.L. (2007)
Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface. (PubMed id 16081103)^{1, 3} Li Y....Lavie A. (2005)
Expression of ZO-1 and occludin in normal human placenta and in hydatidiform moles. (PubMed id 11228248)^{1, 3} Marzioni D....Castellucci M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4950	HGNC: 8104	AceView: OCLN	Ensembl:ENSG00000197822	euGenes: HUgn4950
ECgene: OCLN	H-InvDB: OCLN

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Occludin

Licensable Technologies for OCLN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OCLN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OCLN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OCLN		Antibodies for OCLN
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OCLN		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (OCLN)
	Antibodies (OCLN)
	Chimera RNAi (OCLN)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Occludin)
	Antibodies (Occludin)

Search OriGene for OCLN

Search Tocris compounds for OCLN

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for OCLN

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OCLN Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for OCLN

Summaries
for OCLN

Genomic Location
for OCLN

Proteins
for OCLN

Protein Domains/
Families
for OCLN

Gene Function
for OCLN

Pathways & Interactions
for OCLN

Drugs & Compounds
for OCLN

Transcripts
for OCLN

Expression
for OCLN

Orthologs
for OCLN

Paralogs
for OCLN

SNPs/Variants
for OCLN

Disorders & Mutations
for OCLN

Medical News
for OCLN

Publications
for OCLN

Search for OCLN

Genome Databases showing OCLN

Other Databases showing OCLN

Specialized Databases showing OCLN

Licensable Technologies
for OCLN

Services
for OCLN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OCLN Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor OCLN

Summariesfor OCLN

Genomic Locationfor OCLN

Proteinsfor OCLN

Protein Domains/Familiesfor OCLN

Gene Functionfor OCLN

Pathways & Interactionsfor OCLN

Drugs & Compoundsfor OCLN

Transcriptsfor OCLN

Expression for OCLN

Orthologsfor OCLN

Paralogsfor OCLN

SNPs/Variantsfor OCLN

Disorders & Mutationsfor OCLN

Medical Newsfor OCLN

Publicationsfor OCLN

Search for OCLN

Genome Databases showing OCLN

Other Databases showing OCLN

Specialized Databases showing OCLN

Licensable Technologiesfor OCLN

Servicesfor OCLN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OCLN

Summaries
for OCLN

Genomic Location
for OCLN

Proteins
for OCLN

Protein Domains/
Families
for OCLN

Gene Function
for OCLN

Pathways & Interactions
for OCLN

Drugs & Compounds
for OCLN

Transcripts
for OCLN

Expression
for OCLN

Orthologs
for OCLN

Paralogs
for OCLN

SNPs/Variants
for OCLN

Disorders & Mutations
for OCLN

Medical News
for OCLN

Publications
for OCLN

Licensable Technologies
for OCLN

Services
for OCLN