OCLM Gene
protein-coding GIFtS: 35
GCID: GC01P186369
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oculomedin
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Aliases
for OCLM gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oculomedin1 | | TISR2 3 | | Trabecular Meshwork Inducible Stretch Response Protein2 | | Trabecular Meshwork-Inducible Stretch Response Protein3 |
Export aliases for OCLM gene to outside databasesPrevious GC identifers: GC01P183895 GC01P181797 GC01P182889 GC01U900851 GC01P183608 GC01P183101 GC01P184636 |
Summaries
for OCLM gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OCLM:
The protein encoded by this gene is induced by cyclic mechanical stretching in trabecular cells of the eye and it isalso expressed in retina. This protein may play a role in trabecular meshwork function and the development ofglaucoma. (provided by RefSeq, Jul 2008)
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Genomic Views
for OCLM gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OCLM gene promoter:
HFH-3 TBP AML1a Nkx2-5 C/EBPalpha FOXI1 CHOP-10 TFIID Zic3 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for OCLM
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCLM |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q25 Ensembl cytogenetic band: 1q31.1 HGNC cytogenetic band: 1q25OCLM Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P186369: view genomic region
(about GC identifiers)
Start:
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186,369,704 bp from pter |
End:
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186,370,587 bp from pter |
Size:
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884 bases |
Orientation:
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plus strand |
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Proteins
for OCLM gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TISR_HUMAN, Q9Y5M6 (See
protein sequence)Recommended Name: Oculomedin Size: 44 amino acids; 5321 Da
Secondary accessions: Q4G0F9Explore the universe of human proteins at neXtProt for OCLM: NX_Q9Y5M6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y5M6
OCLM Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_071770.1
ENSEMBL proteins: ENSP00000460371
Human Recombinant Protein Products:
OCLM Antibody Products:
Assay Products for OCLM: |
Protein
Domains /
Families
for OCLM gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9Y5M6 |
Function
for OCLM gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCLM
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCLM
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): OCLM (NM_001199906) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OCLM | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCLM |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCLM |
|
Pathways & Interactions
for OCLM gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OCLM
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
OCLM for ontologies About GeneDecksing
|
Drugs & Compounds
for OCLM gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OCLM
Search CenterWatch for drugs/clinical trials and news about OCLM / TISR
|
Transcripts
for OCLM gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OCLM gene: NM_022375.3 Unigene Cluster for OCLM: Oculomedin Hs.679230 Unigene Representative Sequence: BC0690961 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000574641(uc001gry.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCLM
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCLM
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): OCLM (NM_001199906) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OCLM | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCLM |
Additional cDNA sequence: BC069096.1 BC093987.1 BC093989.1 1 DOTS entry: DT.99949122 4 AceView cDNA sequences: BF964361 CD299370 AW851405 BF964342
GeneLoc Exon Structure
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Expression
for OCLM gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OCLM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAACAATTGG
About this image
Genevestigator expression for OCLM
SOURCE GeneReport for Unigene cluster: Hs.679230
UniProtKB/Swiss-Prot: TISR_HUMAN, Q9Y5M6Tissue specificity: Expressed in eye trabeculum; also expressed in retina
SABiosciences Custom PCR Arrays for OCLM
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat OCLM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCLM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCLM | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCLM |
Orthologs
for OCLM gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OCLM (if available)
TreeFam Gene Tree for OCLM (if available) |
Paralogs
for OCLM gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for OCLM gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OCLM (186369704 - 186370587 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OCLM: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for OCLM gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OCLM for disorders About GeneDecksing
OMIM gene information: 604301
OMIM disorders: --
3  diseases for OCLM: About MalaCardsopen-angle glaucoma glaucoma primary open angle glaucoma
Export disorders for OCLM gene to outside databases
|
Publications
for OCLM gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OCLM gene integrated from 9 sources:
(articles sorted by number of sources associating them with OCLM) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye. (PubMed id 10362512)1, 2, 3, 9 Sato Y.... Ohtsuki H. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Protein expression, genomic structure, and polymorphisms of oculomedin. (PubMed id 12868032)1, 9 Fujiwara N....Ohtsuki H. (2003)
- Absence of trabecular meshwork-inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients. (PubMed id 11129344)1, 9 Leung Y.F....Pang C.P. (2000)
- Evaluation of the Oculomedin gene in the etiology of primary open angle and exfoliative glaucoma. (PubMed id 12655282)1 Jansson M....Wadelius C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for OCLM gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing OCLM gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OCLM gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OCLM gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OCLM | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for OCLM gene:
Search GeneIP for patents involving OCLM
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OCLM gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OCLM | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OCLM | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OCLM | | OriGene 3'-UTR Clone for OCLM | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCLM | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCLM | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OCLM | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OCLM | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCLM | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OCLM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCLM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCLM |
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 | | | OCLM Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCLM |
|  |  |  | | | | Search ThermoFisher Antibodies for OCLM |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCLM |
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