Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OCLM Gene

Aliases for OCLM Gene

  • Oculomedin 2 3 5
  • TISR 3 4
  • Trabecular Meshwork Inducible Stretch Response Protein 3
  • Trabecular Meshwork-Inducible Stretch Response Protein 4

External Ids for OCLM Gene

Previous GeneCards Identifiers for OCLM Gene

  • GC01P183895
  • GC01P181797
  • GC01P182889
  • GC01U900851
  • GC01P183608
  • GC01P183101
  • GC01P184636
  • GC01P186369

Summaries for OCLM Gene

Entrez Gene Summary for OCLM Gene

  • The protein encoded by this gene is induced by cyclic mechanical stretching in trabecular cells of the eye and it is also expressed in retina. This protein may play a role in trabecular meshwork function and the development of glaucoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for OCLM Gene

OCLM (Oculomedin) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OCLM Gene

Genomics for OCLM Gene

Regulatory Elements for OCLM Gene

Enhancers for OCLM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OCLM on UCSC Golden Path with GeneCards custom track

Genomic Location for OCLM Gene

186,400,572 bp from pter
186,401,455 bp from pter
884 bases
Plus strand

Genomic View for OCLM Gene

Genes around OCLM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OCLM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OCLM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OCLM Gene

Proteins for OCLM Gene

  • Protein details for OCLM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q4G0F9

    Protein attributes for OCLM Gene

    44 amino acids
    Molecular mass:
    5321 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OCLM Gene

Proteomics data for OCLM Gene at MOPED

Post-translational modifications for OCLM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OCLM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OCLM Gene

Domains & Families for OCLM Gene

Protein Domains for OCLM Gene


Suggested Antigen Peptide Sequences for OCLM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OCLM: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OCLM Gene

Function for OCLM Gene

Phenotypes for OCLM Gene

GenomeRNAi human phenotypes for OCLM:
genes like me logo Genes that share phenotypes with OCLM: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OCLM Gene

Localization for OCLM Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for OCLM Gene

Pathways & Interactions for OCLM Gene

SuperPathways for OCLM Gene

No Data Available

Interacting Proteins for OCLM Gene

Gene Ontology (GO) - Biological Process for OCLM Gene


No data available for Pathways by source and SIGNOR curated interactions for OCLM Gene

Drugs & Compounds for OCLM Gene

No Compound Related Data Available

Transcripts for OCLM Gene

mRNA/cDNA for OCLM Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OCLM Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OCLM Gene

No ASD Table

Relevant External Links for OCLM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OCLM Gene

mRNA expression in normal human tissues for OCLM Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OCLM Gene

SOURCE GeneReport for Unigene cluster for OCLM Gene Hs.679230

mRNA Expression by UniProt/SwissProt for OCLM Gene

Tissue specificity: Expressed in eye trabeculum; also expressed in retina.
genes like me logo Genes that share expression patterns with OCLM: view

Protein tissue co-expression partners for OCLM Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for OCLM Gene

Orthologs for OCLM Gene

Evolution for OCLM Gene

Gene Tree for OCLM (if available)
Gene Tree for OCLM (if available)

No data available for Orthologs for OCLM Gene

Paralogs for OCLM Gene

No data available for Paralogs for OCLM Gene

Variants for OCLM Gene

Structural Variations from Database of Genomic Variants (DGV) for OCLM Gene

Variant ID Type Subtype PubMed ID
nsv872589 CNV Loss 21882294

Variation tolerance for OCLM Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for OCLM Gene

Disorders for OCLM Gene

Relevant External Links for OCLM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OCLM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OCLM Gene

Publications for OCLM Gene

  1. A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye. (PMID: 10362512) Sato Y. … Ohtsuki H. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23 67
  2. Protein expression, genomic structure, and polymorphisms of oculomedin. (PMID: 12868032) Fujiwara N. … Ohtsuki H. (Ophthalmic Genet. 2003) 3 23
  3. Absence of trabecular meshwork-inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients. (PMID: 11129344) Leung Y.F. … Pang C.P. (Hum. Genet. 2000) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Evaluation of the Oculomedin gene in the etiology of primary open angle and exfoliative glaucoma. (PMID: 12655282) Jansson M. … Wadelius C. (Mol. Vis. 2003) 3

Products for OCLM Gene

Sources for OCLM Gene