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Aliases &
Descriptions
for OCLM
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| TISR 2, 3 | | oculomedin 2 |
| | | Descriptions |
|---|
| Trabecular meshwork-inducible stretch response protein 3 | | trabecular meshwork inducible stretch response protein 2 |
|
| |
Search outside databases for aliases for OCLM genePrevious GC identifers: GC01P183895 GC01P181797 GC01P182889 GC01U900851 GC01P183608 GC01P183101 |
Summaries
for OCLM(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for OCLM:
The protein encoded by this gene is induced by cyclic mechanical stretching in trabecular cells of
the eye and it is also expressed in retina. This protein may play a role in trabecular meshwork
function and the development of glaucoma. [provided by RefSeq]
|
Genomic Location
for OCLM
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the OCLM gene 
Entrez Gene cytogenetic band: 1q25 HGNC cytogenetic band: 1q25OCLM Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P184636:
(about GC identifiers)
Start:
|
184,636,327 bp from pter |
End:
|
184,637,210 bp from pter |
Size:
|
884 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins
for OCLM
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TISR_HUMAN, Q9Y5M6 (See
protein sequence)Recommended Name: Oculomedin Size: 44 amino acids; 5321 Da
Secondary accessions: Q4G0F9REFSEQ proteins: NP_071770.1
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
Antibodies for OCLM:
Assays for OCLM: | Protein
Domains/
Families
for OCLM(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9Y5M6 | Gene Function
for OCLM
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022375
 Applied Biosystems Silencer® siRNAs for OCLM
 Sigma-Aldrich siRNA for OCLM
Sigma-Aldrich shRNA for OCLM
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_022375
Myc/DDK tagged cDNA clone in CMV expression vector: NM_022375
untagged cDNA clone in CMV expression vector: NM_022375
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_022375
| Pathways & Interactions
for OCLM
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
--1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds
for OCLM(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for OCLM
|
Transcripts
for OCLM(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022375
Sigma-Aldrich siRNA for OCLM
Sigma-Aldrich shRNA for OCLM
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_022375 REFSEQ mRNAs for OCLM gene: NM_022375.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_022375
OriGene GFP tagged cDNA clone in CMV expression vector: NM_022375
Myc/DDK tagged cDNA clone in CMV expression vector: NM_022375
untagged cDNA clone in CMV expression vector: NM_022375
Additional cDNA sequence: BC069096.1 BC093987.1 BC093989.1 1 DOTS entry: DT.99949122 4 AceView cDNA sequences:BF964361 CD299370 AW851405 BF964342
 highest scoring ESTs for OCLM:AF142063 AW851405 BC069096 BC093987 BC093989 NM_022375 CN427431 DA345468 Unigene Cluster for OCLM: Oculomedin Hs.679230 Unigene Representative Sequence: BC069096
GeneLoc Exon Structure
|
Expression
for OCLM
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OCLM expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OCLM
1 / 2 / 3 2 probe-sets matching OCLM gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CAACAATTGG
SOURCE GeneReport for Unigene cluster: Hs.679230
UniProtKB/Swiss-Prot: TISR_HUMAN, Q9Y5M6Tissue specificity: Expressed in eye trabeculum; also expressed in retina |
Orthologs
for OCLM
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
--
| Paralogs
for OCLM(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for OCLM(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations
for OCLM
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604301
|
Medical News
for OCLM(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for OCLM (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 6 PubMed articles for OCLM gene:- A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye. (PubMed id 10362512)1, 2, 3, 4 Sato Y.... Ohtsuki H. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Protein expression, genomic structure, and polymorphisms of oculomedin. (PubMed id 12868032)1, 3 Fujiwara N....Ohtsuki H. (2003)
- Evaluation of the Oculomedin gene in the etiology of primary open angle and exfoliative glaucoma. (PubMed id 12655282)3 Jansson M....Wadelius C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Absence of trabecular meshwork-inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients. (PubMed id 11129344)1 Leung Y.F....Pang C.P. (2000)
|
Search for OCLM
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OCLM
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OCLM
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OCLM(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for OCLM(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for OCLM:
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