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OCIAD2 Gene

protein-coding   GIFtS: 43

GC04M048582
OCIA domain containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for OCIAD2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp686C03164 2
MGC45416 1, 2
Descriptions
OCIA domain containing 2 2
Ovarian carcinoma immunoreactive antigen-like protein 3
ovarian carcinoma immunoreactive antigen 2
External Ids
HGNC: 286851
Entrez Gene: 1322992
UniProtKB: Q56VL33
Ensembl: ENSG000001452477
Search outside databases for aliases for OCIAD2 gene

Previous GC identifer: GC04M048728

Summaries
for OCIAD2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for OCIAD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OCIAD2 gene  

Entrez Gene cytogenetic band: 4p12   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p12

OCIAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M048582:     (about GC identifiers)

Start:
 48,582,162 bp from pter
End:
 48,603,572 bp from pter
Size:
 21,411 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000004.10  NT_006238.10  

Proteins
for OCIAD2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: OCAD2_HUMAN, Q56VL3 (See protein sequence)
Recommended Name: OCIA domain-containing protein 2  
Size: 154 amino acids; 16954 Da
Subcellular location: Endosome (Probable)
Secondary accessions: Q8N544
Alternative splicing: 2 isoforms:  Q56VL3-1   Q56VL3-2   

REFSEQ proteins (2 alternative transcripts): 
NP_001014446.1  NP_689611.1  


ENSEMBL proteins: 
ENSP00000273860 ENSP00000370873 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005739 mitochondrion IEA--
GO:0005743 mitochondrial inner membrane IEA--
GO:0005768 endosome IEA--
About this table

Antibodies for OCIAD2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for OCIAD2

Assays for OCIAD2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for OCIAD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR009764 OCIA


   GeneDecks  OCIAD2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q56VL3

ProtoNet protein and cluster: Q56VL3

UniProtKB/Swiss-Prot: OCAD2_HUMAN, Q56VL3
Similarity: Contains 1 OCIA domain

Gene Function
for OCIAD2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (OCIAD2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001014446

              Applied Biosystems Silencer® siRNAs for OCIAD2

              Sigma-Aldrich siRNA for OCIAD2  
                     Sigma-Aldrich shRNA for OCIAD2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for OCIAD2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001014446
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001014446
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001014446 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001014446

Pathways & Interactions
for OCIAD2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for OCIAD2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OCIAD2

Transcripts
for OCIAD2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (OCIAD2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001014446

              Sigma-Aldrich siRNA for OCIAD2  
                     Sigma-Aldrich shRNA for OCIAD2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001014446  NM_152398  

REFSEQ mRNAs for OCIAD2 gene (2 alternative transcripts): 

NM_001014446.1   NM_152398.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001014446  NM_152398  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001014446
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001014446
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001014446 

Additional cDNA sequence: 

AK298305.1 AY472117.1 BC032808.1 

9 DOTS entries:

DT.95070082  DT.95070083  DT.100788305  DT.121253644  DT.100028383  DT.218199  DT.120639503  DT.121253630 
DT.97845148 

24/202 AceView cDNA sequences (see all 202 ):

AI093528 AI672933 BG165990 BM782144 AA303514 AI184832 AI088656 AA303607 
CB125969 AA464688 BQ231024 CA842427 CB135703 AI220135 BU628169 AI308968 
BU726791 BM504230 AI371106 W78953 BQ083875 AI077951 AI022131 AI161403 

highest scoring ESTs for OCIAD2:

AA056216 AA149518 AA306672 AA847380 AW955265 BC032808 BG167015 BG217421 AA040438 AA056217 

Unigene Cluster for OCIAD2:

OCIA domain containing 2
Hs.95835  [show with all ESTs]
Unigene Representative Sequence: AK298305


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for OCIAD2

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
SP1:                    -                 -     -               
SP2:                                                            
SP3:                                                            

About this scheme

ECgene alternative splicing isoforms for OCIAD2

2 Ensembl transcripts including schematic representations:
ENST00000273860  ENST00000381464  

Expression
for OCIAD2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OCIAD2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OCIAD2

1 / 2 / 3

3 probe-sets matching OCIAD2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
46706_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA149518 0.80 1.00 0.91 1

225314_at2, 3 U133-B 1 1.00 1.00 -- -- BG291649 0.20 1.00 0.72 1

225314_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  OCIAD2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GATTAAGTGA

SOURCE GeneReport for Unigene cluster: Hs.95835

Orthologs
for OCIAD2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for OCIAD2 gene from 4 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 OCIAD21   -- OCIA domain containing 2 99.03(n)
97.1(a)		 461338  XM_517305.2  XP_517305.2 
cow
(Bos taurus)		 OCIAD21   -- OCIA domain containing 2 88.74(n)
85.06(a)		 505877  NM_001034258.1  NP_001029430.1 
mouse
(Mus musculus)		 Ociad21, 5 55
 OCIA domain containing 21, 5 85.71(n)1
84.42(a)1		 4339041  NM_026950.31  NP_081226.11 
 AK0076175  BC0448835  (see all 6)
zebrafish
(Danio rerio)		 ociad21   -- OCIA domain containing 2 53.28(n)
45.67(a)		 558261  NM_001044856.2  NP_001038321.1 
About this table        Species with no ortholog for OCIAD2

ENSEMBL Gene Tree for OCIAD2

Paralogs
for OCIAD2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for OCIAD2 gene
OCIAD12  

SNPs/Variants
for OCIAD2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/104 NCBI SNPs in OCIAD2 are shown (see all 104 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 33)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 4 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs76853601,2
A,C48581847(+) tttcgC/Tctcct 2 -- ng510--------
--
rs76769161,2
C,H48596635(+) ATTCTC/TGCATA 2 R/Q mis14Minor allele frequency- T:0.00EU EA WA 404
rs22890651,2
A,C,F,H48589738(-) ACCAGT/CGTTGA 2 -- int113Minor allele frequency- C:0.49EA EU WA NA 2542
rs109385451,2
A,C,F,H48601879(+) GTGGTG/ACACTA 2 -- int14Minor allele frequency- A:0.01EU EA WA 420
rs29252131,2
C,F,H,O48593411(+) ATAAAA/GTCCTG 2 -- int17Minor allele frequency- G:0.03EU EA WA NA 560
rs22905161,2
A,C,F,H48603111(-) CCCCCA/GCCCCC 2 -- int14Minor allele frequency- G:0.48EU EA WA 418
rs109385461,2
A,C,F,H48602153(+) tggagT/Aatatg 2 -- int14Minor allele frequency- A:0.13EU EA WA 376
rs64476741,2
C,F,H48591944(+) ggcgaT/Cgcctt 2 -- int14Minor allele frequency- C:0.12EU EA WA 416
--
rs64476731,2
A,C,H48591314(+) GAATTG/TAACTC 2 -- int14Minor allele frequency- T:0.00EU EA WA 418
--
rs23549481,2
A,C48602592(+) GGTCAA/GAGAGA 2 -- int10--------
About this table

HapMap Linkage Disequilibrium images for OCIAD2 (up to first 250kb)

Disorders & Mutations
for OCIAD2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for OCIAD2

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for OCIAD2

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

6 PubMed articles for OCIAD2 gene:

Search for OCIAD2

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing OCIAD2

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 132299 HGNC: 28685 AceView: OCIAD2 Ensembl:ENSG00000145247 euGenes: HUgn132299
ECgene: OCIAD2 H-InvDB: OCIAD2

Other Databases showing OCIAD2

(According to HUGE)
About This Section

   --

Specialized Databases showing OCIAD2

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for OCIAD2

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for OCIAD2

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OCIAD2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for OCIAD2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for OCIAD2 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OCIAD2 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for OCIAD2

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