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Aliases for OCIAD2 Gene

Aliases for OCIAD2 Gene

  • OCIA Domain Containing 2 2 3 5
  • Ovarian Carcinoma Immunoreactive Antigen-Like Protein 4

External Ids for OCIAD2 Gene

Previous GeneCards Identifiers for OCIAD2 Gene

  • GC04M048728
  • GC04M048582
  • GC04M048207

Summaries for OCIAD2 Gene

GeneCards Summary for OCIAD2 Gene

OCIAD2 (OCIA Domain Containing 2) is a Protein Coding gene. Diseases associated with OCIAD2 include Ovarian Mucinous Neoplasm. An important paralog of this gene is OCIAD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OCIAD2 Gene

Genomics for OCIAD2 Gene

Regulatory Elements for OCIAD2 Gene

Enhancers for OCIAD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F048877 0.5 ENCODE 12.3 +29.2 29155 1.5 CTCF REST RAD21 OCIAD1 OCIAD2 OCIAD1-AS1
GH04F048578 0.4 ENCODE 11.5 +328.4 328369 0.1 SMARCA5 CTCF ZNF654 ARNT CEBPB ARID4B TRIM22 REST RAD21 ATF3 OCIAD2 ZAR1 OCIAD1-AS1 RNU5E-3P GC04P048658
GH04F048953 1.3 Ensembl ENCODE 11.3 -48.1 -48092 2.3 NFRKB NR4A1 TEAD4 DPF2 RELA ZNF217 CREB3 GATA3 CTBP1 JUND OCIAD2 CWH43 OCIAD1 GC04M048853
GH04F048944 1 Ensembl ENCODE 11.1 -37.9 -37882 1.4 CTCF CBX3 PKNOX1 SCRT2 IKZF1 BACH1 ZNF384 RAD21 OCIAD2 CWH43 OCIAD1-AS1 OCIAD1 ENSG00000251334 GC04M048853
GH04F048838 0.5 FANTOM5 11 +68.6 68551 0.0 OCIAD1-AS1 OCIAD1 OCIAD2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OCIAD2 on UCSC Golden Path with GeneCards custom track

Promoters for OCIAD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001240749 437 1401 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 ZNF2 YY1 GLIS2 ZNF548 SP3

Genomic Location for OCIAD2 Gene

Chromosome:
4
Start:
48,885,019 bp from pter
End:
48,906,937 bp from pter
Size:
21,919 bases
Orientation:
Minus strand

Genomic View for OCIAD2 Gene

Genes around OCIAD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OCIAD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OCIAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OCIAD2 Gene

Proteins for OCIAD2 Gene

  • Protein details for OCIAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q56VL3-OCAD2_HUMAN
    Recommended name:
    OCIA domain-containing protein 2
    Protein Accession:
    Q56VL3
    Secondary Accessions:
    • B4DPE7
    • Q8N544

    Protein attributes for OCIAD2 Gene

    Size:
    154 amino acids
    Molecular mass:
    16954 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OCIAD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OCIAD2 Gene

Post-translational modifications for OCIAD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OCIAD2 Gene

No data available for DME Specific Peptides for OCIAD2 Gene

Domains & Families for OCIAD2 Gene

Protein Domains for OCIAD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OCIAD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q56VL3

UniProtKB/Swiss-Prot:

OCAD2_HUMAN :
  • Contains 1 OCIA domain.
Domain:
  • Contains 1 OCIA domain.
genes like me logo Genes that share domains with OCIAD2: view

No data available for Gene Families for OCIAD2 Gene

Function for OCIAD2 Gene

Phenotypes for OCIAD2 Gene

GenomeRNAi human phenotypes for OCIAD2:
genes like me logo Genes that share phenotypes with OCIAD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OCIAD2

miRNA for OCIAD2 Gene

miRTarBase miRNAs that target OCIAD2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OCIAD2 Gene

Localization for OCIAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OCIAD2 Gene

Endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OCIAD2 Gene COMPARTMENTS Subcellular localization image for OCIAD2 gene
Compartment Confidence
mitochondrion 4
endosome 3
extracellular 2
peroxisome 2
plasma membrane 2
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OCIAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with OCIAD2: view

Pathways & Interactions for OCIAD2 Gene

SuperPathways for OCIAD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OCIAD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OCIAD2 Gene

Transcripts for OCIAD2 Gene

Unigene Clusters for OCIAD2 Gene

OCIA domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OCIAD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - - -
SP2:
SP3:

Relevant External Links for OCIAD2 Gene

GeneLoc Exon Structure for
OCIAD2
ECgene alternative splicing isoforms for
OCIAD2

Expression for OCIAD2 Gene

mRNA expression in normal human tissues for OCIAD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OCIAD2 Gene

This gene is overexpressed in Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for OCIAD2 Gene

This gene is overexpressed in Nasal epithelium (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OCIAD2 Gene



Protein tissue co-expression partners for OCIAD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OCIAD2 Gene:

OCIAD2

SOURCE GeneReport for Unigene cluster for OCIAD2 Gene:

Hs.95835
genes like me logo Genes that share expression patterns with OCIAD2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for OCIAD2 Gene

Orthologs for OCIAD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OCIAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OCIAD2 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia OCIAD2 34 35
  • 88.74 (n)
dog
(Canis familiaris)
Mammalia OCIAD2 34 35
  • 87.23 (n)
mouse
(Mus musculus)
Mammalia Ociad2 34 16 35
  • 85.71 (n)
rat
(Rattus norvegicus)
Mammalia Ociad2 34
  • 85.28 (n)
oppossum
(Monodelphis domestica)
Mammalia OCIAD2 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OCIAD2 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ociad2 34
  • 59.9 (n)
zebrafish
(Danio rerio)
Actinopterygii ociad2 34 35
  • 54.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta asrij 35
  • 15 (a)
OneToMany
Species where no ortholog for OCIAD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OCIAD2 Gene

ENSEMBL:
Gene Tree for OCIAD2 (if available)
TreeFam:
Gene Tree for OCIAD2 (if available)

Paralogs for OCIAD2 Gene

Paralogs for OCIAD2 Gene

(1) SIMAP similar genes for OCIAD2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for OCIAD2 Gene

genes like me logo Genes that share paralogs with OCIAD2: view

Variants for OCIAD2 Gene

Sequence variations from dbSNP and Humsavar for OCIAD2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10938545 -- 48,905,105(+) GTGGT(A/G)CACTA intron-variant
rs10938546 -- 48,905,379(+) TGGAG(A/T)ATATG intron-variant
rs111512197 -- 48,903,733(+) CTCCG(C/T)CTCCT intron-variant
rs111534013 -- 48,889,806(+) GCACA(A/C/G)GTATG intron-variant
rs111606658 -- 48,893,180(+) GGCCA(C/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OCIAD2 Gene

Variant ID Type Subtype PubMed ID
esv3600469 CNV gain 21293372
nsv1010381 CNV gain 25217958
nsv1011910 CNV gain 25217958

Variation tolerance for OCIAD2 Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OCIAD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OCIAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OCIAD2 Gene

Disorders for OCIAD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OCIAD2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian mucinous neoplasm
  • malignant ovarian mucinous neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for OCIAD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OCIAD2
genes like me logo Genes that share disorders with OCIAD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OCIAD2 Gene

Publications for OCIAD2 Gene

  1. OCIA domain containing 2 is highly expressed in adenocarcinoma mixed subtype with bronchioloalveolar carcinoma component and is associated with better prognosis. (PMID: 17054434) Ishiyama T. … Noguchi M. (Cancer Sci. 2007) 2 3 22 64
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  3. OCIAD2 activates I^-secretase to enhance amyloid I^ production by interacting with nicastrin. (PMID: 24270855) Han J. … Jung Y.K. (Cell. Mol. Life Sci. 2014) 3 64
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3 64
  5. Pathway bridge based multiobjective optimization approach for lurking pathway prediction. (PMID: 24949437) Zhang R. … Zhou X. (Biomed Res Int 2014) 3 64

Products for OCIAD2 Gene

Sources for OCIAD2 Gene

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