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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OCIAD2 Gene

protein-coding   GIFtS: 46
GCID: GC04M048887

OCIA domain containing 2
 Explore 5 diseases affiliated with
OCIAD2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OCIAD2    

Aliases
for OCIAD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
OCIA Domain Containing 21 2
Ovarian Carcinoma Immunoreactive Antigen-Like Protein2 3
MGC454161
OCIA Domain-Containing Protein 22
Ovarian Carcinoma Immunoreactive Antigen2

External Ids:    HGNC: 286851   Entrez Gene: 1322992   Ensembl: ENSG000001452477   UniProtKB: Q56VL33   

Export aliases for OCIAD2 gene to outside databases

Previous GC identifers: GC04M048728 GC04M048582 GC04M048207


Summaries
for OCIAD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for OCIAD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006238.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OCIAD2 gene promoter:
         GR   HOXA9   HOXA9B   GR-beta   CUTL1   HNF-3beta   GR-alpha   Meis-1a   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OCIAD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OCIAD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCIAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p11   Ensembl cytogenetic band:  4p11   HGNC cytogenetic band: 4p12

OCIAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OCIAD2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M048887:  view genomic region     (about GC identifiers)

Start:
 48,887,036 bp from pter      End:
 48,908,954 bp from pter
Size:
 21,919 bases      Orientation:
 minus strand

Proteins
for OCIAD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OCAD2_HUMAN, Q56VL3 (See protein sequence)
Recommended Name: OCIA domain-containing protein 2  
Size: 154 amino acids; 16954 Da
Subcellular location: Endosome (Probable)
Secondary accessions: B4DPE7 Q8N544
Alternative splicing: 2 isoforms:  Q56VL3-1   Q56VL3-2   

Explore the universe of human proteins at neXtProt for OCIAD2: NX_Q56VL3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q56VL3

    • OCIAD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001014446.1  NP_689611.1  

    ENSEMBL proteins: 
     ENSP00000423014   ENSP00000273860   ENSP00000370873   ENSP00000425452  

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    Uscn Proteins for OCIAD2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005768endosome IEA--


    OCIAD2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for OCIAD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OCIAD2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009764 OCIA

    Graphical View of Domain Structure for InterPro Entry Q56VL3

    ProtoNet protein and cluster: Q56VL3

    UniProtKB/Swiss-Prot: OCAD2_HUMAN, Q56VL3
    Similarity: Contains 1 OCIA domain


    Function
    for OCIAD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for OCIAD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OCIAD2

    Drugs & Compounds
    for OCIAD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OCIAD2
    Search CenterWatch for drugs/clinical trials and news about OCIAD2 / OCAD2 

    Transcripts
    for OCIAD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for OCIAD2 gene (2 alternative transcripts): 
    NM_001014446.1  NM_152398.2  

    Unigene Cluster for OCIAD2:

    OCIA domain containing 2
    Hs.95835  [show with all ESTs]
    Unigene Representative Sequence: AK298305
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508632(uc003gyt.3 uc003gyu.3) ENST00000514576 ENST00000508069
    ENST00000273860 ENST00000506226 ENST00000381464 ENST00000512087 ENST00000510159
    ENST00000514155

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK298305.1 AY472117.1 BC032808.1 

    9 DOTS entries:

    DT.95070082  DT.95070083  DT.100788305  DT.121253644  DT.100028383  DT.218199  DT.120639503  DT.121253630 
    DT.97845148 

    24/202 AceView cDNA sequences (see all 202):

    AA303514 AI022131 AA992512 BG747862 BU508058 CA312106 AI672933 BU726791 
    CB125969 AI077951 AA056216 AI161403 AA772960 AI342232 AA284154 AI346693 
    BQ231024 W78953 AA303607 AA303545 CB160672 AI215791 BU628169 AA872832 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for OCIAD2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
    SP1:                    -                 -     -               
    SP2:                                                            
    SP3:                                                            


    ECgene alternative splicing isoforms for OCIAD2

    Expression
    for OCIAD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OCIAD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATTAAGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    OCIAD2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OCIAD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OCIAD2

    SOURCE GeneReport for Unigene cluster: Hs.95835
        SABiosciences Custom PCR Arrays for OCIAD2
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    In Situ
    Assay Products:     
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    Orthologs
    for OCIAD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for OCIAD2 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ociad21 , 5 OCIA domain containing 21, 5 85.71(n)1
    84.42(a)1    		   5 (38.54 cM)5
    4339041  NM_026950.31  NP_081226.11 
     733221995 
    lizard
    (Anolis carolinensis)    		 Reptilia OCIAD26
    		 --
    		 49(a)
    		 1 ↔ 1
    		 GL343293.1(1084937-1092420)
    zebrafish
    (Danio rerio)    		 Actinopterygii ociad21 OCIA domain containing 2 53.28(n)
    45.67(a)    		   558261  NM_001044856.2  NP_001038321.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta asrij6
    		 asrij
    		 14(a)
    		 1 → many
    		 2R(18773921-18775101)


    ENSEMBL Gene Tree for OCIAD2 (if available)
    TreeFam Gene Tree for OCIAD2 (if available) 

    Paralogs
    for OCIAD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OCIAD2 gene
    OCIAD12  
    1 SIMAP similar gene for OCIAD2 using alignment to 3 protein entries:     OCAD2_HUMAN (see all proteins):
    OCIAD1

    OCIAD2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OCIAD2
    PGOHUM00000249401


    Genomic Variants
    for OCIAD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for OCIAD2
         1 CNV: 80280
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for OCIAD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OCIAD2 for disorders           About GeneDecksing

    5 diseases for OCIAD2:    About MalaCards
    bronchiolo-alveolar adenocarcinoma    ovarian mucinous neoplasm    adenocarcinoma    carcinoma
    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for OCIAD2:
    Ovarian mucinous neoplasm

    Export disorders for OCIAD2 gene to outside databases

    Publications
    for OCIAD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OCIAD2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with OCIAD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. OCIA domain containing 2 is highly expressed in adenocarcinoma mixed subtype with bronchioloalveolar carcinoma component and is associated with better prognosis. (PubMed id 17054434)1, 3, 9 Ishiyama T....Noguchi M. (2007)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Increased expression of OCIA domain containing 2 durin g stepwise progression of ovarian mucinous tumor. (PubMed id 22726067)1 Nagata C....Noguchi M. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    External Searches for OCIAD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OCIAD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 132299 HGNC: 28685 AceView: OCIAD2 Ensembl:ENSG00000145247 euGenes: HUgn132299
    ECgene: OCIAD2 H-InvDB: OCIAD2

    Other Databases showing OCIAD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OCIAD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OCIAD2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for OCIAD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OCIAD2 gene:
    Search GeneIP for patents involving OCIAD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for OCIAD2 gene

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    About This Section

     
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