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OCIAD1 Gene

protein-coding   GIFtS: 50

GC04P048527
OCIA domain containing 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
Asrij 1, 2
FLJ20455 1, 2
MGC111072 2
OCIA 1, 2, 3
OTTHUMP00000128288 2
TPA018 1, 2
Descriptions
OCIA domain containing 1 2
Ovarian carcinoma immunoreactive antigen 2, 3
External Ids
HGNC: 160741
Entrez Gene: 549402
UniProtKB: Q9NX403
Ensembl: ENSG000001091807
Search outside databases for aliases for OCIAD1 gene

Previous GC identifer: GC04P048674

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OCIAD1 gene  

Entrez Gene cytogenetic band: 4p11   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p11

OCIAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P048527:     (about GC identifiers)

Start:
48,527,772 bp from pter
End:
48,558,589 bp from pter
Size:
30,818 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000004.10  NT_006238.10  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OCAD1_HUMAN, Q9NX40 (See protein sequence)
Recommended Name: OCIA domain-containing protein 1  
Size: 245 amino acids; 27626 Da
Subcellular location: Endosome (By similarity)
Secondary accessions: Q9BZE8
Alternative splicing: 2 isoforms:  Q9NX40-1   Q9NX40-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (5 alternative transcripts): 
    NP_001073308.1  NP_001073309.1  NP_001073310.1  NP_001073311.1  NP_060300.1  


    ENSEMBL proteins: 
    ENSP00000370882 ENSP00000264312 ENSP00000379725 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (OCIAD1)
    Human Recombinant Proteins from Abnova (OCIAD1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768 endosome IEA--
    About this table

    Antibodies for OCIAD1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for OCIAD1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (OCIAD1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (OCIAD1)
    Novus Biologicals Antibodies for OCIAD1

    Assays for OCIAD1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR009764 OCIA


       GeneDecks  OCIAD1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9NX40

    ProtoNet protein and cluster: Q9NX40

    UniProtKB/Swiss-Prot: OCAD1_HUMAN, Q9NX40
    Similarity: Belongs to the OCIAD1 family
    Similarity: Contains 1 OCIA domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (OCIAD1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (OCIAD1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_017830

                  Applied Biosystems Silencer® siRNAs for OCIAD1

                  Sigma-Aldrich siRNA for OCIAD1  
                         Sigma-Aldrich shRNA for OCIAD1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for OCIAD1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001079839
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001079839
                                     untagged cDNA clones in CMV expression vector (see all 6): NM_001079839 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_017830

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for OCIAD1 (ENSP000002643123) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC35F2ENSP000002658363STRING (score=.72)
    PPP1CBENSP000003512983STRING (score=.708)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for OCIAD1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (OCIAD1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (OCIAD1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_017830

                  Sigma-Aldrich siRNA for OCIAD1  
                         Sigma-Aldrich shRNA for OCIAD1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001079839  NM_001079840  NM_001079841  NM_001079842  NM_017830  

    REFSEQ mRNAs for OCIAD1 gene (5 alternative transcripts): 

    NM_001079839.1   NM_001079840.1   NM_001079841.1   NM_001079842.1   NM_017830.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001079839  NM_001079840  NM_001079841  NM_001079842  NM_017830  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001079839
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001079839
                                     untagged cDNA clones in CMV expression vector (see all 6): NM_001079839 

    Additional cDNA sequence: 

    AF251296.1 AF323665.1 AF324350.1 AK000462.1 AK024302.1 AK123529.1 AK297864.1 BC003409.1 
    BC088361.1 CR591070.1 CR592468.1 CR593373.1 CR599869.1 CR606711.1 CR612142.1 CR612891.1 
    CR614441.1 CR618578.1 CR621465.1 CR624767.1 CR624940.1 CR625789.1 CR626387.1 

    24/35 DOTS entries (see all 35 ):

    DT.40229238  DT.100676158  DT.100872342  DT.95336231  DT.451735  DT.95336223  DT.100641694  DT.100864337 
    DT.97860024  DT.121272342  DT.40313820  DT.121272425  DT.40107202  DT.91931819  DT.92446122  DT.100676166 
    DT.121272385  DT.91881991  DT.97860026  DT.100676156  DT.100676167  DT.102844003  DT.121272343  DT.91809021 

    24/479 AceView cDNA sequences (see all 479 ):

    BQ267326 CB164674 AA464695 BQ064594 AA405647 AA731128 AI123977 AI633473 
    BX339838 AI125169 CR626387 AI371024 AW342097 AL539411 BX107724 AA152292 
    BU070752 CR606711 NM_017830 T16347 BG678731 BQ716312 AA878212 AA902532 

    highest scoring ESTs for OCIAD1:

    AA045036 AA098894 AA099856 AA131268 AA142975 AA143151 AA150234 AA151528 AA151608 AA152292 

    Unigene Cluster for OCIAD1:

    OCIA domain containing 1
    Hs.518750  [show with all ESTs]
    Unigene Representative Sequence: NM_001079839


    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for OCIAD1 (see all 18 )

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^
    SP1:                                            -     -     -     -     -     -                 -                             -                       -     -   
    SP2:                                            -     -     -     -     -     -                 -                             -                             -   
    SP3:                                            -     -     -     -     -     -                 -                             -                       -     -   
    SP4:                                            -     -     -     -     -     -                 -                             -                       -         
    SP5:                                                                                            -                             -                       -     -   

    ExUns: 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d
    SP1:                                                
    SP2:  -     -     -     -                           
    SP3:  -     -     -     -                           
    SP4:                                                
    SP5:                                                

    About this scheme

    ECgene alternative splicing isoforms for OCIAD1

    3 Ensembl transcripts including schematic representations:
    ENST00000381473  ENST00000264312  ENST00000396448  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    OCIAD1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for OCIAD1

    1 / 2 / 3

    12 probe-sets matching OCIAD1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    64142_r_at2, 3 U95-C 1 1.00 1.00 0.18 0.49 AI371024 0.80 1.00 0.91 1

    64141_f_at2, 3 U95-C 1 1.00 1.00 0.94 1.36 AI371024 0.80 1.00 0.91 1
    56555_at2, 3 U95-B 1 1.00 1.00 0.87 1.02 AI890560 0.80 1.00 0.91 1
    61113_at2, 3 U95-C 1 1.00 1.00 0.96 1.13 W93810 0.80 1.00 0.91 1

    223011_s_at2, 3 U133-B 1 1.00 1.00 -- -- AF323665 0.80 1.00 0.91 1

    223010_s_at2, 3 U133-B 1 1.00 1.00 -- -- AA454649 0.60 1.00 0.82 1

    239748_x_at2 U133-B 28 1.00 0.69 -- -- -- -- -- -- --

    232644_x_at*2, 3 U133-B 68 1.00 0.56 -- -- AK024302 0.20 1.00 0.72 1

    223011_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    223010_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    239748_x_at2 U133Plus2 26 1.00 0.73 -- -- -- -- -- -- --

    232644_x_at*2 U133Plus2 68 1.00 0.56 -- -- -- -- -- -- --
    GeneDecks  OCIAD1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTGAATTGGG

    SOURCE GeneReport for Unigene cluster: Hs.518750

    UniProtKB/Swiss-Prot: OCAD1_HUMAN, Q9NX40
    Tissue specificity: Isoform 1 is highly expressed in many tissues, including testis, brain,
    placenta, ovary, prostate and mammary gland. Isoform 2 expression is restricted to the central
    nervous system including brain, cerebellum and spinal cord,

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for OCIAD1 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    OCIAD11   -- OCIA domain containing 1 94.01(n)
    93.47(a)
    475140  XM_844495.1  XP_849588.1 
    chimpanzee
    (Pan troglodytes)
    OCIAD11   -- OCIA domain containing 1 99.59(n)
    99.59(a)
    461339  XM_001151174.1  XP_001151174.1 
    cow
    (Bos taurus)
    OCIAD11   -- OCIA domain containing 1 93.74(n)
    92.24(a)
    533520  NM_001015648.1  NP_001015648.1 
    rat
    (Rattus norvegicus)
    Ociad11   -- OCIA domain containing 1 87.62(n)
    86.12(a)
    289590  NM_001013874.1  NP_001013896.1 
    mouse
    (Mus musculus)
    Ociad11, 5 55
    OCIA domain containing 11, 5 86.94(n)1
    86.12(a)1
    680951  NM_023429.31  NP_075918.11 
     AA5011995  AF2953575  (see all 34)
    About this table        Species with no ortholog for OCIAD1

    ENSEMBL Gene Tree for OCIAD1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for OCIAD1 gene
    OCIAD22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/107 NCBI SNPs in OCIAD1 are shown (see all 107 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 28)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs176566411,2
    C,F,H48526888(+) GTTAGC/TGAACC 5 -- ng5112Minor allele frequency- N:0.00NA EU EA WA 1054
    rs176567631,2
    F,H48558019(+) AACATG/ACAACA 5 -- ut317Minor allele frequency- A:0.02NA EU EA WA 550
    rs10640891,2
    H48527405(+) GTAGAA/TCTTGT 5 -- ng514Minor allele frequency- T:0.00EU EA WA 418
    --
    rs27121571,2
    C48525996(+) accacC/Tgtact 5 -- ng510--------
    --
    rs115415511,2
    C48546829(+) ATCAGG/TACAAG 5 G/V mis10--------
    rs27121581,2
    A,C,F,H,O48552144(-) TTATAT/CTGGGA 5 -- int111Minor allele frequency- C:0.39EU EA WA NA 980
    rs23549421,2
    A,C,F,H,O48535302(+) ACCAGA/GTGATA 5 -- int17Minor allele frequency- G:0.02EU EA WA NA 556
    rs25723501,2
    A,C,F,H,O48540403(+) ACATAT/GAAGCG 5 -- int19Minor allele frequency- G:0.49EA NA EU WA 2110
    rs37617291,2
    A,C,F,H48546694(-) AAAGTA/GTAACT 5 -- int18Minor allele frequency- G:0.49NA EU EA WA 646
    rs46949061,2
    A,C,F,H48529653(+) ttgcaC/Gtgggc 5 -- int14Minor allele frequency- G:0.38EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for OCIAD1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/11 PubMed articles for OCIAD1 gene (see all 11 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 54940 HGNC: 16074 AceView: OCIAD1 Ensembl:ENSG00000109180 euGenes: HUgn54940
    ECgene: OCIAD1 H-InvDB: OCIAD1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for OCIAD1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for OCIAD1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for OCIAD1 Antibodies for OCIAD1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for OCIAD1 Browse small molecules at Sigma-Aldrich
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