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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OCIAD1 Gene

protein-coding   GIFtS: 46
GCID: GC04P048833

OCIA domain containing 1

 Explore 5 diseases affiliated with
OCIAD1 via our new
 Human Malady Compendium 
Biological research products
for OCIAD1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
OCIA Domain Containing 11 2     Asrij1
OCIA1 2 3     FLJ204551
TPA0181 2     ASRIJ2
Ovarian Carcinoma Immunoreactive Antigen2 3     OCIA Domain-Containing Protein 12

External Ids:    HGNC: 160741   Entrez Gene: 549402   Ensembl: ENSG000001091807   UniProtKB: Q9NX403   

Export aliases for OCIAD1 gene to outside databases

Previous GC identifers: GC04P048674 GC04P048527 GC04P048152


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006238.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OCIAD1 gene promoter:
         TBP   STAT5B   AML1a   STAT5A   C/EBPalpha   MZF-1   Cart-1   STAT3   c-Myb   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOCIAD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OCIAD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCIAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p11   Ensembl cytogenetic band:  4p11   HGNC cytogenetic band: 4p11

OCIAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OCIAD1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P048833:  view genomic region     (about GC identifiers)

Start:
48,807,229 bp from pter      End:
48,863,834 bp from pter
Size:
56,606 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OCAD1_HUMAN, Q9NX40 (See protein sequence)
Recommended Name: OCIA domain-containing protein 1  
Size: 245 amino acids; 27626 Da
Subcellular location: Endosome (By similarity)
Secondary accessions: C9K030 G8JLN7 Q9BZE8
Alternative splicing: 4 isoforms:  Q9NX40-1   Q9NX40-2   Q9NX40-3   Q9NX40-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OCIAD1: NX_Q9NX40

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NX40

  • OCIAD1 Protein expression data from MOPED and PaxDb:    About this image 
    OCIAD1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001073308.1  NP_001073309.1  NP_001073310.1  NP_001073311.2  NP_001161726.1  NP_060300.1  

    ENSEMBL proteins: 
     ENSP00000423381   ENSP00000424041   ENSP00000422171   ENSP00000423126   ENSP00000423845  
     ENSP00000421582   ENSP00000424252   ENSP00000420917   ENSP00000264312   ENSP00000379725  
     ENSP00000426386   ENSP00000426902   ENSP00000427389   ENSP00000370882   ENSP00000399656  
     ENSP00000425633   ENSP00000420881   ENSP00000427363   ENSP00000425356   ENSP00000421572  
     ENSP00000425968   ENSP00000423002   ENSP00000423909   ENSP00000416943  

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    Novus Biologicals OCIAD1 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OCIAD1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005768endosome IEA--

    OCIAD1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for OCIAD1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OCIAD1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009764 OCIA

    Graphical View of Domain Structure for InterPro Entry Q9NX40

    ProtoNet protein and cluster: Q9NX40

    UniProtKB/Swiss-Prot: OCAD1_HUMAN, Q9NX40
    Similarity: Belongs to the OCIAD1 family
    Similarity: Contains 1 OCIA domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    OCIAD1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OCIAD1 

    miRNA
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    hsa-miR-1287 hsa-miR-16-2* hsa-miR-4272 hsa-miR-181c* hsa-miR-374a hsa-miR-421 hsa-miR-320e hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidOCIAD1 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCIAD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OCIAD1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/6 Interacting proteins for OCIAD1 (Q9NX401, 3 ENSP000002643124) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7P175441, 3EBI-2683029,EBI-765623 I2D: score=1 
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ARF1P840773I2D: score=5 
    SLC23A1Q9UHI73I2D: score=5 
    PTK2Q053973I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OCIAD1
    Search CenterWatch for drugs/clinical trials and news about OCIAD1 / OCAD1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OCIAD1 gene (6 alternative transcripts): 
    NM_001079839.2  NM_001079840.2  NM_001079841.2  NM_001079842.2  NM_001168254.1  NM_017830.3  

    Unigene Cluster for OCIAD1:

    OCIA domain containing 1
    Hs.518750  [show with all ESTs]
    Unigene Representative Sequence: NM_001079839
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000504654 ENST00000509122 ENST00000509664 ENST00000505922 ENST00000514981
    ENST00000512981(uc011bzk.2) ENST00000511662 ENST00000508996 ENST00000507210
    ENST00000264312 ENST00000396448 ENST00000512236 ENST00000509164 ENST00000511102
    ENST00000381473 ENST00000444354(uc003gyo.3 uc003gyq.3 uc003gyp.3)
    ENST00000509963 ENST00000509246

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OCIAD1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate OCIAD1 (see all 25):
    hsa-miR-1287 hsa-miR-16-2* hsa-miR-4272 hsa-miR-181c* hsa-miR-374a hsa-miR-421 hsa-miR-320e hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidOCIAD1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCIAD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCIAD1

    Additional cDNA sequence: 

    AF251296.1 AF323665.1 AF324350.1 AK000462.1 AK024302.1 AK123529.1 AK297864.1 BC003409.1 
    BC088361.1 

    24/35 DOTS entries (see all 35):

    DT.40229238  DT.100676158  DT.100872342  DT.95336231  DT.451735  DT.95336223  DT.100641694  DT.97860024 
    DT.100864337  DT.121272342  DT.40313820  DT.121272425  DT.40107202  DT.91931819  DT.92446122  DT.100676166 
    DT.91881991  DT.97860026  DT.100676156  DT.100676167  DT.102844003  DT.121272343  DT.121272385  DT.91809021 

    24/479 AceView cDNA sequences (see all 479):

    BU949576 AW873084 BM986737 AI745053 CB134957 N75627 AW631074 AA805117 
    AA731128 CA941643 BU070515 AI125169 CR599869 BX107724 AI589306 BQ082672 
    AA909819 AW614151 AW166446 AA933936 BM759603 BU787888 AI928819 BQ019487 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for OCIAD1 (see all 18)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^
    SP1:                                            -     -     -     -     -     -                 -                             -                       -     -   
    SP2:                                            -     -     -     -     -     -                 -                             -                             -   
    SP3:                                            -     -     -     -     -     -                 -                             -                       -     -   
    SP4:                                            -     -     -     -     -     -                 -                             -                       -         
    SP5:                                                                                            -                             -                       -     -   

    ExUns: 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d
    SP1:                                                
    SP2:  -     -     -     -                           
    SP3:  -     -     -     -                           
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for OCIAD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OCIAD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGAATTGGG
    OCIAD1 Expression
    About this image
    See OCIAD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OCIAD1

    SOURCE GeneReport for Unigene cluster: Hs.518750

    UniProtKB/Swiss-Prot: OCAD1_HUMAN, Q9NX40
    Tissue specificity: Isoform 1 is highly expressed in many tissues, including testis, brain, placenta, ovary, prostate
    and mammary gland. Isoform 2 expression is restricted to the central nervous system including brain, cerebellum and
    spinal cord

        SABiosciences Custom PCR Arrays for OCIAD1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCIAD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OCIAD1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves OCIAD11 OCIA domain containing 1 61.51(n)
    51.88(a)
      422764  XM_420717.3  XP_420717.2 
    lizard
    (Anolis carolinensis)
    Reptilia OCIAD16
    --
    50(a)
    1 ↔ 1
    GL343293.1(1069931-1080754)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.153492 Transcribed sequence with weak similarity to protein more 72.79(n)    AL777111.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ociad11 OCIA domain containing 1 56.56(n)
    52.49(a)
      393272  NM_200302.1  NP_956596.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta asrij1 CG13533-PA 43.05(n)
    36.32(a)
      37637  NM_137889.2  NP_611733.1 


    ENSEMBL Gene Tree for OCIAD1 (if available)
    TreeFam Gene Tree for OCIAD1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OCIAD1 gene
    OCIAD22  
    1 SIMAP similar gene for OCIAD1 using alignment to 16 protein entries:     OCAD1_HUMAN (see all proteins):
    OCIAD2

    OCIAD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/420 NCBI SNPs in OCIAD1 are shown (see all 420    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs68347291,2
    C--48831137(+) ctgggC/Tgtggt 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs27121571,2
    C,F,H--48831239(+) ACCACT/CGTACT 3 -- us2k16Minor allele frequency- C:0.35NA WA EA 364
    rs747838201,2
    --48831255(+) CTAGAA/CAATAG 5 -- us2k10--------
    rs1413445901,2
    --48831327(+) ACCTAA/GAATGT 6 -- us2k10--------
    rs1503610981,2
    --48831583(+) GCAAGG/TTAACA 6 -- us2k10--------
    rs1380135871,2
    --48831607(+) GGGTGC/TCATGT 6 -- us2k10--------
    rs1493782081,2
    --48832067(+) AGAGTC/TGTACT 6 -- us2k10--------
    rs176566411,2
    C,F,H--48832131(+) GTTAGC/TGAACC 6 -- us2k121Minor allele frequency- N:0.00NA NS EA 2284
    rs1474761501,2
    --48832246(+) AAACAC/TAGCGT 6 -- us2k10--------
    rs1898993311,2
    --48832259(+) GATTCA/GTTTCA 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for OCIAD1 (48807229 - 48863834 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for OCIAD1: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OCIAD1 for disorders           About GeneDecksing

    5 diseases for OCIAD1:    About MalaCards
    ovarian carcinoma    carcinoma    parkinson's disease    ovarian cancer
    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: OCIAD1 (1 document)

    Export disorders for OCIAD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OCIAD1 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with OCIAD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human gene on chromosome 4p11 by immunoscreening of an ovarian carcinoma cDNA library. (PubMed id 11162530)1, 2, 3 Luo L.Y.... Diamandis E.P. (2001)
    2. Ovarian cancer immuno-reactive antigen domain contain ing 1 (OCIAD1), a key player in ovarian cancer cell adhesion. (PubMed id 18328549)1, 3 Sengupta S....Ganapathi R. (2008)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Increased expression of OCIA domain containing 2 durin g stepwise progression of ovarian mucinous tumor. (PubMed id 22726067)1 Nagata C....Noguchi M. (2012)
    7. Expression of NCAM and OCIAD1 in well-differentiated t hyroid carcinoma: correlation with the risk of distant metastasis. (PubMed id 22081784)1 Yang A.H....Chen J.Y. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54940 HGNC: 16074 AceView: OCIAD1 Ensembl:ENSG00000109180 euGenes: HUgn54940
    ECgene: OCIAD1 H-InvDB: OCIAD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OCIAD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OCIAD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OCIAD1 gene:
    Search GeneIP for patents involving OCIAD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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