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Aliases for OCIAD1 Gene

Aliases for OCIAD1 Gene

  • OCIA Domain Containing 1 2 3 5
  • Ovarian Cancer Immunoreactive Antigen Domain Containing 1 3 4
  • Ovarian Carcinoma Immunoreactive Antigen 3 4
  • ASRIJ 3 4
  • OCIA 3 4
  • OCIA Domain-Containing Protein 1 3
  • TPA018 3

External Ids for OCIAD1 Gene

Previous GeneCards Identifiers for OCIAD1 Gene

  • GC04P048674
  • GC04P048527
  • GC04P048152

Summaries for OCIAD1 Gene

GeneCards Summary for OCIAD1 Gene

OCIAD1 (OCIA Domain Containing 1) is a Protein Coding gene. Diseases associated with OCIAD1 include Ovarian Cancer and Ovarian Mucinous Neoplasm. An important paralog of this gene is OCIAD2.

UniProtKB/Swiss-Prot for OCIAD1 Gene

  • Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946).

Additional gene information for OCIAD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OCIAD1 Gene

Genomics for OCIAD1 Gene

GeneHancer (GH) Regulatory Elements for OCIAD1 Gene

Promoters and enhancers for OCIAD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I048830 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 576.1 +26.6 26553 3.1 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 OCIAD1 OCIAD2 OCIAD1-AS1 NFXL1
GH04I048775 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 24.3 -26.8 -26778 6.8 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 YY1 POLR2B ZNF766 ZNF207 FRYL OCIAD1 SLAIN2 NFXL1 TEC SLC10A4 GC04P048658
GH04I048725 Enhancer 1.3 FANTOM5 Ensembl ENCODE 23 -78.6 -78588 2.1 HDGF ZNF76 ZNF335 FOS EGR2 USF2 ZEB2 ZFP69B ZNF610 KLF16 OCIAD1 NFXL1 SLC10A4 FRYL GC04P048658
GH04I048904 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 9.6 +100.9 100938 2.5 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 YY1 GLIS2 ZNF143 ATF7 OCIAD2 OCIAD1 OCIAD1-AS1 GC04M048853
GH04I048697 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.1 -105.6 -105563 4.5 PKNOX1 SMAD1 ATF1 FOXA2 ARNT YY1 NCOA2 TCF12 ZNF121 FOS OCIAD1 SLC10A4 CWH43 GC04P048658 FRYL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OCIAD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OCIAD1 gene promoter:

Genomic Locations for OCIAD1 Gene

Genomic Locations for OCIAD1 Gene
chr4:48,805,212-48,861,817
(GRCh38/hg38)
Size:
56,606 bases
Orientation:
Plus strand
chr4:48,807,229-48,863,834
(GRCh37/hg19)

Genomic View for OCIAD1 Gene

Genes around OCIAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OCIAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OCIAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OCIAD1 Gene

Proteins for OCIAD1 Gene

  • Protein details for OCIAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX40-OCAD1_HUMAN
    Recommended name:
    OCIA domain-containing protein 1
    Protein Accession:
    Q9NX40
    Secondary Accessions:
    • C9K030
    • G8JLN7
    • Q9BZE8

    Protein attributes for OCIAD1 Gene

    Size:
    245 amino acids
    Molecular mass:
    27626 Da
    Quaternary structure:
    • Interacts with STAT3.
    Miscellaneous:
    • Asrij stands for blood in Sanskrit as this protein is strongly expressed in blood vessels.

    Alternative splice isoforms for OCIAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OCIAD1 Gene

Post-translational modifications for OCIAD1 Gene

Antibody Products

  • Abcam antibodies for OCIAD1
  • Santa Cruz Biotechnology (SCBT) Antibodies for OCIAD1

No data available for DME Specific Peptides for OCIAD1 Gene

Domains & Families for OCIAD1 Gene

Gene Families for OCIAD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for OCIAD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OCIAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX40

UniProtKB/Swiss-Prot:

OCAD1_HUMAN :
  • The OCIA domain is necessary and sufficient for endosomal localization.
  • Belongs to the OCIAD1 family.
Domain:
  • The OCIA domain is necessary and sufficient for endosomal localization.
Family:
  • Belongs to the OCIAD1 family.
genes like me logo Genes that share domains with OCIAD1: view

Function for OCIAD1 Gene

Molecular function for OCIAD1 Gene

UniProtKB/Swiss-Prot Function:
Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946).

Gene Ontology (GO) - Molecular Function for OCIAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with OCIAD1: view

Phenotypes for OCIAD1 Gene

genes like me logo Genes that share phenotypes with OCIAD1: view

Animal Model Products

miRNA for OCIAD1 Gene

miRTarBase miRNAs that target OCIAD1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OCIAD1 Gene

Localization for OCIAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OCIAD1 Gene

Endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OCIAD1 gene
Compartment Confidence
endosome 5
mitochondrion 4
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OCIAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005768 endosome ISS --
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with OCIAD1: view

Pathways & Interactions for OCIAD1 Gene

SuperPathways for OCIAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OCIAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000736 regulation of stem cell differentiation ISS --
genes like me logo Genes that share ontologies with OCIAD1: view

No data available for Pathways by source and SIGNOR curated interactions for OCIAD1 Gene

Drugs & Compounds for OCIAD1 Gene

No Compound Related Data Available

Transcripts for OCIAD1 Gene

Unigene Clusters for OCIAD1 Gene

OCIA domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OCIAD1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - - -
SP11: - - - -
SP12: - -
SP13: - - - - - - - - - - - -
SP14: - - - - -
SP15: - - - - -
SP16:
SP17: -
SP18: -

ExUns: 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d
SP1:
SP2: - - - -
SP3: - - - -
SP4:
SP5:
SP6: - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for OCIAD1 Gene

GeneLoc Exon Structure for
OCIAD1
ECgene alternative splicing isoforms for
OCIAD1

Expression for OCIAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OCIAD1 Gene

Protein differential expression in normal tissues from HIPED for OCIAD1 Gene

This gene is overexpressed in Nasal epithelium (36.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OCIAD1 Gene



Protein tissue co-expression partners for OCIAD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OCIAD1 Gene:

OCIAD1

SOURCE GeneReport for Unigene cluster for OCIAD1 Gene:

Hs.518750

mRNA Expression by UniProt/SwissProt for OCIAD1 Gene:

Q9NX40-OCAD1_HUMAN
Tissue specificity: Isoform 1 is highly expressed in many tissues, including testis, brain, placenta, ovary, prostate and mammary gland. Isoform 2 expression is restricted to the central nervous system including brain, cerebellum and spinal cord.

Evidence on tissue expression from TISSUES for OCIAD1 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Pancreas(2.4)
  • Thyroid gland(2.1)
  • Adrenal gland(2)
  • Heart(2)
  • Kidney(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with OCIAD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OCIAD1 Gene

Orthologs for OCIAD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OCIAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OCIAD1 33 34
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia OCIAD1 33 34
  • 94.01 (n)
cow
(Bos Taurus)
Mammalia OCIAD1 33 34
  • 93.74 (n)
rat
(Rattus norvegicus)
Mammalia Ociad1 33
  • 87.62 (n)
mouse
(Mus musculus)
Mammalia Ociad1 33 16 34
  • 86.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OCIAD1 34
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OCIAD1 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves OCIAD1 33 34
  • 61.65 (n)
lizard
(Anolis carolinensis)
Reptilia OCIAD1 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ociad1 33
  • 60.79 (n)
Str.15349 33
zebrafish
(Danio rerio)
Actinopterygii ociad1 33 34
  • 56.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta asrij 33 34
  • 41.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007618 33
  • 39.7 (n)
Species where no ortholog for OCIAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OCIAD1 Gene

ENSEMBL:
Gene Tree for OCIAD1 (if available)
TreeFam:
Gene Tree for OCIAD1 (if available)

Paralogs for OCIAD1 Gene

Paralogs for OCIAD1 Gene

genes like me logo Genes that share paralogs with OCIAD1: view

Variants for OCIAD1 Gene

Sequence variations from dbSNP and Humsavar for OCIAD1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000062002 -- 48,861,820(+) G/A downstream_transcript_variant
rs1000423242 -- 48,834,352(+) A/G intron_variant
rs1000826100 -- 48,832,408(+) C/G intron_variant
rs1000880229 -- 48,833,996(+) A/T intron_variant
rs1000882908 -- 48,838,965(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OCIAD1 Gene

Variant ID Type Subtype PubMed ID
nsv1010381 CNV gain 25217958
nsv1011910 CNV gain 25217958
nsv1074710 CNV deletion 25765185
nsv1121731 CNV deletion 24896259
nsv1149780 CNV deletion 26484159

Variation tolerance for OCIAD1 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OCIAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OCIAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OCIAD1 Gene

Disorders for OCIAD1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OCIAD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
ovarian mucinous neoplasm
  • malignant ovarian mucinous neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OCIAD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OCIAD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OCIAD1 Gene

Publications for OCIAD1 Gene

  1. Molecular cloning of a novel human gene on chromosome 4p11 by immunoscreening of an ovarian carcinoma cDNA library. (PMID: 11162530) Luo LY … Diamandis EP (Biochemical and biophysical research communications 2001) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Role of the 18:1 lysophosphatidic acid-ovarian cancer immunoreactive antigen domain containing 1 (OCIAD1)-integrin axis in generating late-stage ovarian cancer. (PMID: 20515946) Wang C … Sengupta S (Molecular cancer therapeutics 2010) 3 4 58
  4. Ovarian cancer immuno-reactive antigen domain containing 1 (OCIAD1), a key player in ovarian cancer cell adhesion. (PMID: 18328549) Sengupta S … Ganapathi R (Gynecologic oncology 2008) 2 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for OCIAD1 Gene

Sources for OCIAD1 Gene

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