OCEL1 Gene
protein-coding GIFtS: 43
GCID: GC19P017337
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|
occludin/ELL domain containing 1
| |
Aliases
for OCEL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Occludin/ELL Domain Containing 11 2 | | FLJ227091 | | FWP0092 | | S863-92 | | Occludin/ELL Domain-Containing Protein 12 |
Export aliases for OCEL1 gene to outside databasesPrevious GC identifers: GC19P017201 GC19P016904 |
Summaries
for OCEL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for OCEL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OCEL1 gene promoter:
AhR USF1 NRSF form 1 MyoD USF2 USF-1:USF-2 Nkx2-5 NRSF form 2 Arnt USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OCEL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCEL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11OCEL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P017337: view genomic region
(about GC identifiers)
Start:
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17,337,055 bp from pter |
End:
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17,340,028 bp from pter |
Size:
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2,974 bases |
Orientation:
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plus strand |
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Proteins
for OCEL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OCEL1_HUMAN, Q9H607 (See
protein sequence)Recommended Name: Occludin/ELL domain-containing protein 1 Size: 264 amino acids; 29404 DaExplore the universe of human proteins at neXtProt for OCEL1: NX_Q9H607
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H607
OCEL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078854.1
ENSEMBL proteins: ENSP00000215061
Human Recombinant Protein Products for OCEL1:
OCEL1 Antibody Products:
Assay Products for OCEL1: |
Protein
Domains /
Families
for OCEL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OCEL1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H607ProtoNet protein and cluster: Q9H607 1 Blocks protein family: IPB010844 Occludin and RNA polymerase II elongation factor ELL
UniProtKB/Swiss-Prot: OCEL1_HUMAN, Q9H607Similarity: Belongs to the ELL/occludin family |
Function
for OCEL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
3 GenomeRNAi human phenotypes for OCEL1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCEL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCEL1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OCEL1 (NM_024578) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OCEL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCEL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCEL1 |
|
Pathways & Interactions
for OCEL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OCEL1
|
Drugs & Compounds
for OCEL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OCEL1
Search CenterWatch for drugs/clinical trials and news about OCEL1
|
Transcripts
for OCEL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OCEL1 gene: NM_024578.1 Unigene Cluster for OCEL1: Occludin/ELL domain containing 1 Hs.422676 [show with all ESTs]Unigene Representative Sequence: BC0389451 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000215061(uc002nfp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCEL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCEL1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OCEL1 (NM_024578) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OCEL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCEL1 |
Additional cDNA sequence: AF109191.1 AK026362.1 BC004121.2 BC029361.1 BC038945.1 8 DOTS entries: DT.95272108 DT.40251005 DT.314495 DT.91805948 DT.95332178 DT.100781656 DT.121450966 DT.91764258 24/116 AceView cDNA sequences (see all 116): CK300801 BM701945 CR602515 BC029361 BC038945 CK300293 CR598715 BM975221 AI718116 BM979959 BM976080 AK026362 AI290528 BU753491 BG182568 BV179772 AU185792 BC004121 NM_024578 BG219048 CB305463 BI759960 AA372071 T62891
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for OCEL1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | - | | | | | | - | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for OCEL1
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Expression
for OCEL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OCEL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTAGACAC
About this image
See OCEL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OCEL1
SOURCE GeneReport for Unigene cluster: Hs.422676
SABiosciences Custom PCR Arrays for OCEL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OCEL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OCEL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCEL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCEL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCEL1 |
Orthologs
for OCEL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for OCEL1 gene from 1/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
Su(Tpl)6 |
Su(Tpl) |
4(a) |
1 → many |
3L(19882220-19902510) |
ENSEMBL Gene Tree for OCEL1 (if available)
TreeFam Gene Tree for OCEL1 (if available) |
Paralogs
for OCEL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OCEL1 gene
- MARVELD22 ELL32 OCLN2 ELL22 ELL2
1 SIMAP similar gene for OCEL1 using alignment to 10 protein entries: OCEL1_HUMAN (see all proteins):MARVELD2
OCEL1 for paralogs About GeneDecksing
|
Genomic Variants
for OCEL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OCEL1 (17337055 - 17340028 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OCEL1
1 CNV: 30072 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OCEL1 |
|
Disorders
/ Diseases
for OCEL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for OCEL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OCEL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OCEL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for OCEL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OCEL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OCEL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OCEL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OCEL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OCEL1 gene:
Search GeneIP for patents involving OCEL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OCEL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OCEL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OCEL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OCEL1 | | | OriGene Protein Over-expression Lysate for OCEL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OCEL1 | | OriGene 3'-UTR Clone for OCEL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OCEL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OCEL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for OCEL1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OCEL1 | | OriGene Custom Protein Services for OCEL1 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OCEL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OCEL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCEL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OCEL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCEL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCEL1 |
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 |  |  |  | |
| | | | Search Tocris compounds for OCEL1 |
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 | | | OCEL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCEL1 |
|  |  |  |  | | | | ThermoFisher Antibodies for OCEL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCEL1 |
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