OCEL1 Gene
protein-coding GIFtS: 43
GCID: GC19P017337
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Occludin/ELL Domain Containing 1
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Aliases
for OCEL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Occludin/ELL Domain Containing 11 2 | | FWP0092 | | S863-92 | | Occludin/ELL Domain-Containing Protein 12 |
Export aliases for OCEL1 gene to outside databasesPrevious GC identifers: GC19P017201 GC19P016904 |
Summaries
for OCEL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for OCEL1 Gene: 
OCEL1 (occludin/ELL domain containing 1) is a protein-coding gene. An important paralog of this gene is MARVELD2.
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Genomic Views
for OCEL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NT_011295.11 NC_018930.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OCEL1 gene promoter:
AhR USF1 NRSF form 1 MyoD USF2 USF-1:USF-2 Nkx2-5 NRSF form 2 Arnt USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OCEL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCEL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11OCEL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P017337: view genomic region
(about GC identifiers)
Start:
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17,337,013 bp from pter |
End:
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17,340,028 bp from pter |
Size:
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3,016 bases |
Orientation:
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plus strand |
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Proteins
for OCEL1 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: OCEL1_HUMAN, Q9H607 (See
protein sequence)Recommended Name: Occludin/ELL domain-containing protein 1 Size: 264 amino acids; 29404 DaExplore the universe of human proteins at neXtProt for OCEL1: NX_Q9H607
Explore proteomics data for OCEL1 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q9H607
OCEL1 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_078854.1
ENSEMBL proteins: ENSP00000215061 ENSP00000471201 ENSP00000469261 ENSP00000470270 ENSP00000471311 ENSP00000470258 ENSP00000471742 ENSP00000470883 ENSP00000469624
Human Recombinant Protein Products for OCEL1:
OCEL1 Antibody Products:
Assay Products for OCEL1: |
Protein
Domains /
Families
for OCEL1 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q9H607 ProtoNet protein and cluster: Q9H607 1 Blocks protein domain: IPB010844 Occludin and RNA polymerase II elongation factor ELL
UniProtKB/Swiss-Prot: OCEL1_HUMAN, Q9H607Similarity: Belongs to the ELL/occludin family
OCEL1 for domains About GeneDecksing
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Function
for OCEL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
3 GenomeRNAi human phenotypes for OCEL1:
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for OCEL1 | |  | Search LifeMap BioReagents cell lines for OCEL1 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCEL1 |
Pathways & Interactions
for OCEL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OCEL1
|
Drugs & Compounds
for OCEL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OCEL1
Search CenterWatch for drugs/clinical trials and news about OCEL1
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Transcripts
for OCEL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OCEL1 gene: NM_024578.1 Unigene Cluster for OCEL1: Occludin/ELL domain containing 1 Hs.422676 [show with all ESTs]Unigene Representative Sequence: BC03894515 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000215061(uc002nfp.3) ENST00000602236 ENST00000601576 ENST00000601529
ENST00000599588 ENST00000594283 ENST00000600232 ENST00000597836 ENST00000598068
ENST00000596279 ENST00000598172 ENST00000599286 ENST00000595769 ENST00000595573
ENST00000600826
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for OCEL1
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OCEL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCEL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCEL1 |
Additional mRNA sequence: AF109191.1 AK026362.1 BC004121.2 BC029361.1 BC038945.1 8 DOTS entries: DT.95272108 DT.40251005 DT.314495 DT.91805948 DT.95332178 DT.100781656 DT.121450966 DT.91764258 24/116 AceView cDNA sequences (see all 116): AI290528 CK300801 BV179772 AK026362 NM_024578 BM976080 BU753491 BC004121 AI718116 BM975221 BC029361 CR598715 CR602515 CK300293 BC038945 BM701945 AU185792 BM979959 BG182568 CN479597 BQ445920 BG198624 BP365030 BM670823
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for OCEL1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c |
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| SP1: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | - | | | | | | - | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for OCEL1
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Expression
for OCEL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OCEL1 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TATTAGACAC
About this image
See OCEL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OCEL1
SOURCE GeneReport for Unigene cluster: Hs.422676
SABiosciences Custom PCR Arrays for OCEL1
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for OCEL1
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OCEL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCEL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCEL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCEL1 |
Orthologs
for OCEL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for OCEL1 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for OCEL1 (if available)
TreeFam Gene Tree for OCEL1 (if available) |
Paralogs
for OCEL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OCEL1 gene
- MARVELD22 ELL32 ELL22 ELL2
18/21 SIMAP similar genes for OCEL1 using alignment to 10 protein entries: OCEL1_HUMAN (see all proteins)
(see all similar genes):C17orf86 FKBP3 FP1523 FAM175A HMGA2 PTPLA
HKR1 LYRM4 AURA2 LINC00596 ZNF564 DNAPTP3
NF2 UTY SPATS2L SEPT2 MARVELD2 TSEN2
OCEL1 for paralogs About GeneDecksing
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Genomic Variants
for OCEL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OCEL1 (17337013 - 17340028 bp)
Structural Variations
Database of Genomic Variants (DGV) 10 variations for OCEL1: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | SeqTarget long-range PCR primers for resequencing OCEL1 |
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Disorders
/ Diseases
for OCEL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for OCEL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OCEL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OCEL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
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External Searches for OCEL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing OCEL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing OCEL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OCEL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OCEL1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for OCEL1 gene:
Search GeneIP for patents involving OCEL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OCEL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OCEL1 | | | QIAGEN SeqTarget long-range PCR primers for resequencing OCEL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OCEL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OCEL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OCEL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OCEL1 |
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 |  |  |  | |
| | | | Search Tocris compounds for OCEL1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OCEL1 |
|  |  |  |  | | | | ThermoFisher Antibodies for OCEL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OCEL1 |
| |  |  |  | | | | LSBio Antibodies in human, mouse, rat for OCEL1 |
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