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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OC90 Gene

protein-coding   GIFtS: 35
GCID: GC08M133039

Otoconin 90


(Previous symbol: PLA2L)
  Search for OC90
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Otoconin 901 2
PLA2L1 2 3 5
Phospholipase A2 Homolog2 3
otoconin-902
Oc903

External Ids:    HGNC: 81001   Entrez Gene: 7293302   Ensembl: ENSG000002531177   OMIM: 6016585   UniProtKB: Q025093   

Export aliases for OC90 gene to outside databases

Previous GC identifers: GC08U990050 GC08M133069 GC08M132708 GC08M132993 GC08M133105 GC08M128354


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OC90 Gene: 
OC90 (otoconin 90) is a protein-coding gene. GO annotations related to this gene include phospholipase A2 activity and molecular_function. An important paralog of this gene is ENSG00000258417.

UniProtKB/Swiss-Prot: OC90_HUMAN, Q02509
Function: It is unlikely that this protein has phospholipase A2 activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OC90 gene promoter:
         MEF-2   SREBP-1c   SREBP-1b   MEF-2A   POU2F1   SREBP-1a   POU2F1a   Meis-1a   aMEF-2   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OC90

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OC90


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.22   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24.22

OC90 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OC90 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M133039:  view genomic region     (about GC identifiers)

Start:
133,036,467 bp from pter      End:
133,071,627 bp from pter
Size:
35,161 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OC90_HUMAN, Q02509 (See protein sequence)
Recommended Name: Otoconin-90 precursor  
Size: 493 amino acids; 53454 Da
Subunit: Interacts with OTOL1 (By similarity)
Subcellular location: Secreted (By similarity)
Sequence caution: Sequence=CAA78662.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DNG8
Alternative splicing: 2 isoforms:  Q02509-1   Q02509-2   

Explore the universe of human proteins at neXtProt for OC90: NX_Q02509

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q02509

  • OC90 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001073868.2  
    ENSEMBL proteins: 
     ENSP00000254627  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    OC90 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR016090 PLipase_A2_dom
     IPR001211 PLipase_A2
     IPR013090 PLipase_A2_AS

    Graphical View of Domain Structure for InterPro Entry Q02509

    ProtoNet protein and cluster: Q02509

    1 Blocks protein domain: IPB001211 Phospholipase A2

    UniProtKB/Swiss-Prot: OC90_HUMAN, Q02509
    Domain: Consists of 3 PA2-type domains
    Similarity: Belongs to the phospholipase A2 family


    OC90 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OC90_HUMAN, Q02509
    Function: It is unlikely that this protein has phospholipase A2 activity

         Genatlas biochemistry entry for OC90:
    atoconin 90,phospholipase-A2 like secreted protein,linked to HHLA1 by intergenic splicing,homolog to a murine
    protein expressed in fetal inner ear

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004623phospholipase A2 activity IEA--
    GO:0005509calcium ion binding IEA--
         
    OC90 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Oc90):
     hearing/vestibular/ear  normal 

    OC90 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Oc90tm1Ywl for OC90

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OC90

    1 Interacting protein for OC90 (Q025093) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR2Q138733I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process IEA--
    GO:0008150biological_process ND--
    GO:0016042lipid catabolic process IEA--

    OC90 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OC90

    Search CenterWatch for drugs/clinical trials and news about OC90

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OC90 gene: 
    NM_001080399.2  

    Unigene Cluster for OC90:

    Otoconin 90
    Hs.653174  [show with all ESTs]
    Unigene Representative Sequence: NM_001080399
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000254627(uc011lix.1)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OC90

    Additional mRNA sequence: AK297911.1 
    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OC90 expression in normal human tissues (normalized intensities)      OC90 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACCTCCAT
    OC90 Expression
    About this image


    OC90 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles

    SOURCE GeneReport for Unigene cluster: Hs.653174
        SABiosciences Custom PCR Arrays for OC90
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OC90

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OC90 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oc901 , 5 otoconin 901, 5 77.04(n)1
    70.15(a)1
      15 (29.16 cM)5
    182561  NM_010953.21  NP_035083.11 
     658760535 
    chicken
    (Gallus gallus)
    Aves OC901 otoconin 90 60.22(n)
    54.41(a)
      420326  XM_003640875.1  XP_003640923.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    1 → many
    4(240687-266052)
    zebrafish
    (Danio rerio)
    Actinopterygii CR848728.26
    oc906
    otoconin 90
    16(a)
    15(a)
    many ↔ many
    many ↔ many
    2(41720884-41787554)
    2(43043670-43061471)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG145076
    --
    11(a)
    1 → many
    3R(25051926-25053447)
    worm
    (Caenorhabditis elegans)
    Secernentea C07E3.96
    Y69A2AL.26
    Protein Y69A2AL.2
    22(a)
    20(a)
    many ↔ many
    many ↔ many
    II(10350760-10351617)
    IV(2482257-2484112)


    ENSEMBL Gene Tree for OC90 (if available)
    TreeFam Gene Tree for OC90 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OC90 gene
    ENSG000002584172  PLA2G2F2  PLA2G2E2  PLA2G2A2  PLA2G1B2  PLA2G2D2  PLA2G102  PLA2G52  
    PLA2G2C2  
    3 SIMAP similar genes for OC90 using alignment to 1 protein entry:     OC90_HUMAN:
    PLA2G1B    PLA2G2A    PLA2G2E

    OC90 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/968 SNPs in OC90 are shown (see all 968)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113091961,2
    C--133036016(+) TTAAG-/TTTTTT 1 -- ds50010--------
    rs597852651,2
    --133036016(+) TTAAGT/ATTTTT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1145723741,2
    C--133036017(+) TAAGTA/TTTTTT 1 -- ds50010--------
    rs1923669931,2
    C--133036125(+) CTAGGA/GCCCAG 1 -- ds50010--------
    rs1837037661,2
    --133036192(+) AGGCTG/TCCAAG 1 -- ds50010--------
    rs1891026641,2
    --133036243(+) GTCCTC/TGGCAT 1 -- ds50010--------
    rs78421721,2
    C,F,A--133036251(+) CATTGG/ATGGGT 1 -- ds50019Minor allele frequency- A:0.42NA WA CSA EA 370
    rs1929896521,2
    --133036262(+) TATTGA/GTGGCC 1 -- ds50010--------
    rs1847326671,2
    --133036273(+) CACGGA/GTAATC 1 -- ds50010--------
    rs1401710901,2
    C--133036307(+) CTCTT-/CTTTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for OC90 (133036467 - 133071627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OC90:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660746CNV Deletion23128226
    esv28393CNV Loss19812545
    nsv517297CNV Loss19592680
    nsv517992CNV Loss19592680
    nsv891453CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OC90 for disorders           About MalaCards
    OMIM gene information: 601658    OMIM disorders: --


    OC90 for disorders           About GeneDecksing


    Export disorders for OC90 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OC90 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OC90)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes. (PubMed id 10329003)1, 3 Kowalski P.E....Mager D.L. (1999)
    2. Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2. (PubMed id 9860971)1, 3 Wang Y....Thalmann R. (1998)
    3. Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene. (PubMed id 8382789)1, 2 Feuchter-Murthy A.E.... Mager D.L. (1993)
    4. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    5. Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. (PubMed id 15188402)1 Hassel S....Souchelnytskyi S. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 729330 HGNC: 8100 Ensembl:ENSG00000253117 euGenes: HUgn729330 ECgene: OC90
    H-InvDB: OC90

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OC90 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OC90 gene:
    Search GeneIP for patents involving OC90

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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