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OC90 Gene

protein-coding   GIFtS: 35
GCID: GC08M133039

Otoconin 90


(Previous symbol: PLA2L)
  Search for OC90
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Otoconin 901 2
PLA2L1 2 3 5
Phospholipase A2 Homolog2 3
otoconin-902
Oc903

External Ids:    HGNC: 81001   Entrez Gene: 7293302   Ensembl: ENSG000002531177   OMIM: 6016585   UniProtKB: Q025093   

Export aliases for OC90 gene to outside databases

Previous GC identifers: GC08U990050 GC08M133069 GC08M132708 GC08M132993 GC08M133105 GC08M128354


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OC90 Gene:
OC90 (otoconin 90) is a protein-coding gene. GO annotations related to this gene include phospholipase A2 activity and calcium ion binding. An important paralog of this gene is ENSG00000258417.

UniProtKB/Swiss-Prot: OC90_HUMAN, Q02509
Function: It is unlikely that this protein has phospholipase A2 activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the OC90 gene promoter:
         MEF-2   SREBP-1c   SREBP-1b   MEF-2A   POU2F1   SREBP-1a   POU2F1a   Meis-1a   aMEF-2   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OC90

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OC90


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.22   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24.22

OC90 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OC90 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M133039:  view genomic region     (about GC identifiers)

Start:
133,036,467 bp from pter      End:
133,071,627 bp from pter
Size:
35,161 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OC90_HUMAN, Q02509 (See protein sequence)
Recommended Name: Otoconin-90 precursor  
Size: 493 amino acids; 53454 Da
Subunit: Interacts with OTOL1 (By similarity)
Sequence caution: Sequence=CAA78662.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DNG8
Alternative splicing: 2 isoforms:  Q02509-1   Q02509-2   

Explore the universe of human proteins at neXtProt for OC90: NX_Q02509

Explore proteomics data for OC90 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38, Asn179, Asn423

  • See OC90 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073868.2  
    ENSEMBL proteins: 
     ENSP00000254627  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR016090 PLipase_A2_dom
     IPR001211 PLipase_A2
     IPR013090 PLipase_A2_AS

    Graphical View of Domain Structure for InterPro Entry Q02509

    ProtoNet protein and cluster: Q02509

    1 Blocks protein domain: IPB001211 Phospholipase A2

    UniProtKB/Swiss-Prot: OC90_HUMAN, Q02509
    Domain: Consists of 3 PA2-type domains
    Similarity: Belongs to the phospholipase A2 family


    Find genes that share domains with OC90           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OC90_HUMAN, Q02509
    Function: It is unlikely that this protein has phospholipase A2 activity

         Genatlas biochemistry entry for OC90:
    atoconin 90,phospholipase-A2 like secreted protein,linked to HHLA1 by intergenic splicing,homolog to a murine
    protein expressed in fetal inner ear

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004623phospholipase A2 activity IEA--
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with OC90           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Oc90):
     hearing/vestibular/ear  normal 

    Find genes that share phenotypes with OC90           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Oc90tm1Ywl for OC90

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OC90
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OC90_HUMAN, Q02509: Secreted (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with OC90           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OC90
    Interactions:

        Search GeneGlobe Interaction Network for OC90

    1 Interacting protein for OC90 (Q025093) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR2Q138733I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process IEA--
    GO:0008150biological_process ND--
    GO:0016042lipid catabolic process IEA--

    Find genes that share ontologies with OC90           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OC90



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OC90 gene: 
    NM_001080399.2  

    Unigene Cluster for OC90:

    Otoconin 90
    Hs.653174  [show with all ESTs]
    Unigene Representative Sequence: NM_001080399
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000254627(uc011lix.1)
    miRNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OC90
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      QuantiFast Probe-based Assays in human, mouse, rat OC90

    Additional mRNA sequence: AK297911.1 
    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OC90 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACCTCCAT
    OC90 Expression
    About this image


    OC90 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
    OC90 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OC90 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.653174
        Custom PCR Arrays for OC90
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OC90

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for OC90 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oc901 , 5 otoconin 901, 5 77.19(n)1
    70.15(a)1
      15 (29.16 cM)5
    182561  NM_010953.21  NP_035083.11 
     658760535 
    chicken
    (Gallus gallus)
    Aves OC901 otoconin 90 60.29(n)
    54.62(a)
      420326  XM_003640875.1  XP_003640923.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    46(a)
    1 → many
    4(240687-266052)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia oc901 otoconin 90 59.29(n)
    51.67(a)
      100491062  XM_002939511.2  XP_002939557.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CR848728.26
    oc906
    otoconin 90
    16(a)
    15(a)
    many ↔ many
    many ↔ many
    2(41720884-41787554) ENSDARG00000089064
    2(43043670-43061471) ENSDARG00000001721
    worm
    (Caenorhabditis elegans)
    Secernentea C07E3.96
    Protein C07E3.9 (C07E3.9) mRNA, complete cds
    24(a)
    1 → many
    II(10350760-10351617) WBGene00007419


    ENSEMBL Gene Tree for OC90 (if available)
    TreeFam Gene Tree for OC90 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OC90 gene
    ENSG000002584172  PLA2G2F2  PLA2G2E2  PLA2G2A2  PLA2G1B2  PLA2G2D2  PLA2G102  PLA2G52  
    PLA2G2C2  
    3 SIMAP similar genes for OC90 using alignment to 2 protein entries:     OC90_HUMAN (see all proteins):
    PLA2G1B    PLA2G2A    PLA2G2E

    Find genes that share paralogs with OC90           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OC90 (see all 968)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113091961,2
    C--133036016(+) TTAAG-/TTTTTT 1 -- ds50010--------
    rs597852651,2
    --133036016(+) TTAAGT/ATTTTT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1145723741,2
    C--133036017(+) TAAGTA/TTTTTT 1 -- ds50010--------
    rs1923669931,2
    C--133036125(+) CTAGGA/GCCCAG 1 -- ds50010--------
    rs1837037661,2
    --133036192(+) AGGCTG/TCCAAG 1 -- ds50010--------
    rs1891026641,2
    --133036243(+) GTCCTC/TGGCAT 1 -- ds50010--------
    rs78421721,2
    C,F,A--133036251(+) CATTGG/ATGGGT 1 -- ds50019Minor allele frequency- A:0.42NA WA CSA EA 370
    rs1929896521,2
    --133036262(+) TATTGA/GTGGCC 1 -- ds50010--------
    rs1847326671,2
    --133036273(+) CACGGA/GTAATC 1 -- ds50010--------
    rs1401710901,2
    C--133036307(+) CTCTT-/CTTTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for OC90 (133036467 - 133071627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OC90:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660746CNV Deletion23128226
    esv28393CNV Loss19812545
    nsv517297CNV Loss19592680
    nsv517992CNV Loss19592680
    nsv891453CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for OC90

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601658    OMIM disorders: --


    Find genes that share disorders with OC90           About GenesLikeMe


    Export disorders for OC90 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OC90 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OC90)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes. (PubMed id 10329003)1, 3 Kowalski P.E.... Mager D.L. (Genomics 1999)
    2. Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2. (PubMed id 9860971)1, 3 Wang Y....Thalmann R. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene. (PubMed id 8382789)1, 2 Feuchter-Murthy A.E.... Mager D.L. (Nucleic Acids Res. 1993)
    4. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
    5. Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. (PubMed id 15188402)1 Hassel S....Souchelnytskyi S. (Proteomics 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 729330 HGNC: 8100 Ensembl:ENSG00000253117 euGenes: HUgn729330 ECgene: OC90
    H-InvDB: OC90

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OC90 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OC90 gene:
    Search GeneIP for patents involving OC90

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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