OC90 Gene
protein-coding GIFtS: 36
GCID: GC08M133039
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otoconin 90
(Previous symbol: PLA2L)
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Aliases
for OC90 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Otoconin 901 2 | | PLA2L1 2 3 5 | | Phospholipase A2 Homolog2 3 | | Otoconin-901 | | Oc903 |
Export aliases for OC90 gene to outside databasesPrevious GC identifers: GC08U990050 GC08M133069 GC08M132708 GC08M132993 GC08M133105 GC08M128354 |
Summaries
for OC90 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: OC90_HUMAN, Q02509Function: It is unlikely that this protein has phospholipase A2 activity
|
Genomic Views
for OC90 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OC90 gene promoter:
MEF-2 SREBP-1c SREBP-1b MEF-2A POU2F1 SREBP-1a POU2F1a Meis-1a aMEF-2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OC90
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OC90 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.22 Ensembl cytogenetic band: 8q24.22 HGNC cytogenetic band: 8q24.22OC90 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M133039: view genomic region
(about GC identifiers)
Start:
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133,036,467 bp from pter |
End:
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133,071,627 bp from pter |
Size:
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35,161 bases |
Orientation:
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minus strand |
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Proteins
for OC90 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OC90_HUMAN, Q02509 (See
protein sequence)Recommended Name: Otoconin-90 precursor Size: 493 amino acids; 53454 Da
Subunit: Interacts with OTOL1 (By similarity)
Subcellular location: Secreted (By similarity)
Sequence caution: Sequence=CAA78662.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DNG8Alternative splicing: 2 isoforms: Q02509-1 Q02509-2 Explore the universe of human proteins at neXtProt for OC90: NX_Q02509
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q02509
OC90 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001073868.2
ENSEMBL proteins: ENSP00000254627 ENSP00000390050
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005576 | extracellular region |
IEA | -- |
OC90 for ontologies About GeneDecksing
OC90 Antibody Products:
Assay Products for OC90: |
Protein
Domains /
Families
for OC90 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OC90 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q02509ProtoNet protein and cluster: Q02509 1 Blocks protein family: IPB001211 Phospholipase A2
UniProtKB/Swiss-Prot: OC90_HUMAN, Q02509Domain: Consists of 3 PA2-type domainsSimilarity: Belongs to the phospholipase A2 family |
Function
for OC90 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OC90_HUMAN, Q02509Function: It is unlikely that this protein has phospholipase A2 activity Genatlas biochemistry entry for OC90:atoconin 90,phospholipase-A2 like secreted protein,linked to HHLA1 by intergenic splicing,homolog to a murine proteinexpressed in fetal inner ear
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OC90 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OC90
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for OC90 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OC90 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OC90 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OC90 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
OC90 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Oc90tm1Ywl for OC90
2 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Oc90):
OC90 for phenotypes About GeneDecksing
|
Pathways & Interactions
for OC90 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OC90
1 Interacting protein for OC90 (Q025093) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006644 | phospholipid metabolic process |
IEA | -- | | GO:0008150 | biological_process |
ND | -- | | GO:0016042 | lipid catabolic process |
IEA | -- |
OC90 for ontologies About GeneDecksing
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Drugs & Compounds
for OC90 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OC90
Search CenterWatch for drugs/clinical trials and news about OC90
|
Transcripts
for OC90 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OC90 gene: NM_001080399.2 Unigene Cluster for OC90: Otoconin 90 Hs.653174 [show with all ESTs]Unigene Representative Sequence: NM_0010803992 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000254627(uc011lix.1) ENST00000443356(uc003ytg.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OC90 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OC90
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for OC90 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OC90 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OC90 |
Additional cDNA sequence: AK297911.1
GeneLoc Exon Structure
|
Expression
for OC90 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OC90 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTACCTCCAT
About this image
SOURCE GeneReport for Unigene cluster: Hs.653174
SABiosciences Custom PCR Arrays for OC90
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OC90
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OC90 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OC90 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OC90 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OC90 |
Orthologs
for OC90 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for OC90 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for OC90 (if available)
TreeFam Gene Tree for OC90 (if available) |
Paralogs
for OC90 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OC90 gene
- ENSG000002584172 PLA2G2F2 PLA2G1B2 PLA2G2A2 PLA2G2D2 PLA2G2E2 PLA2G102 PLA2G52
- PLA2G2C2
5 SIMAP similar genes for OC90 using alignment to 1 protein entry: OC90_HUMAN:PLA2G1B PLA2G2A PLA2G2E PLA2G10 PLA2G2D
OC90 for paralogs About GeneDecksing
|
Genomic Variants
for OC90 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OC90 (133036467 - 133071627 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for OC90
1 CNV: 65268
7 Indels: 82774 95691 52378 95689 95690 82773 82775 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for OC90 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OC90 for disorders About GeneDecksing
OMIM gene information: 601658
OMIM disorders: --
1  disease for OC90: About MalaCardspancreatitis
Export disorders for OC90 gene to outside databases
|
Publications
for OC90 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OC90 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OC90) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes. (PubMed id 10329003)1, 3 Kowalski P.E....Mager D.L. (1999)
- Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2. (PubMed id 9860971)1, 3 Wang Y....Thalmann R. (1998)
- Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene. (PubMed id 8382789)1, 2 Feuchter-Murthy A.E.... Mager D.L. (1993)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. (PubMed id 15188402)1 Hassel S....Souchelnytskyi S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for OC90 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing OC90 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OC90 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OC90 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OC90 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for OC90 gene:
Search GeneIP for patents involving OC90
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OC90 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OC90 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OC90 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OC90 | | | OriGene Protein Over-expression Lysate for OC90 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OC90 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OC90 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OC90 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OC90 | | OriGene Custom Protein Services for OC90 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OC90 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OC90 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OC90 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OC90 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OC90 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OC90 |
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 | | | OC90 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OC90 |
|  |  |  | | | | Search ThermoFisher Antibodies for OC90 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OC90 |
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