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Aliases for OC90 Gene

Aliases for OC90 Gene

  • Otoconin 90 2 3 5
  • Phospholipase A2 Homolog 3 4
  • PLA2L 3 4
  • Otoconin-90 3
  • Oc90 4

External Ids for OC90 Gene

Previous HGNC Symbols for OC90 Gene

  • PLA2L

Previous GeneCards Identifiers for OC90 Gene

  • GC08U990050
  • GC08M133069
  • GC08M132708
  • GC08M132993
  • GC08M133105
  • GC08M128354
  • GC08M133039

Summaries for OC90 Gene

GeneCards Summary for OC90 Gene

OC90 (Otoconin 90) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is ENSG00000258417.

UniProtKB/Swiss-Prot for OC90 Gene

  • It is unlikely that this protein has phospholipase A2 activity.

Additional gene information for OC90 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OC90 Gene

Genomics for OC90 Gene

GeneHancer (GH) Regulatory Elements for OC90 Gene

Promoters and enhancers for OC90 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I132057 Enhancer 0.6 ENCODE 550.8 +1.5 1461 0.2 CTCF ELF1 FOSL1 CTBP1 JUND MTA1 POLR2A CREB1 ZNF143 FOS GC08M132038 OC90 ENSG00000258417 GC08M131995
GH08I132059 Promoter 0.5 EPDnew 550.8 0.0 -20 0.1 GC08M132038 OC90 ENSG00000258417
GH08I132046 Enhancer 0.7 ENCODE 0.4 +12.4 12431 0.2 CTCF PKNOX1 NEUROD1 BMI1 RFX5 CTBP1 GATA3 RCOR1 FOS SMARCE1 GC08M132038 OC90 ENSG00000258417 GC08M131995
GH08I132045 Enhancer 0.3 ENCODE 0.4 +14.2 14238 0.1 POU5F1 GC08M132038 OC90 GC08M131995 ENSG00000258417
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OC90 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OC90 gene promoter:

Genomic Locations for OC90 Gene

Genomic Locations for OC90 Gene
35,161 bases
Minus strand

Genomic View for OC90 Gene

Genes around OC90 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OC90 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OC90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OC90 Gene

Proteins for OC90 Gene

  • Protein details for OC90 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DNG8

    Protein attributes for OC90 Gene

    493 amino acids
    Molecular mass:
    53454 Da
    Quaternary structure:
    • Interacts with OTOL1.
    • Sequence=CAA78662.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for OC90 Gene


neXtProt entry for OC90 Gene

Post-translational modifications for OC90 Gene

  • Glycosylation at isoforms=238, Asn179, and Asn423

Other Protein References for OC90 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OC90 Gene

Domains & Families for OC90 Gene

Gene Families for OC90 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for OC90 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Consists of 3 PA2-type domains.
  • Belongs to the phospholipase A2 family.
  • Consists of 3 PA2-type domains.
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with OC90: view

Function for OC90 Gene

Molecular function for OC90 Gene

GENATLAS Biochemistry:
atoconin 90,phospholipase-A2 like secreted protein,linked to HHLA1 by intergenic splicing,homolog to a murine protein expressed in fetal inner ear
UniProtKB/Swiss-Prot Function:
It is unlikely that this protein has phospholipase A2 activity.

Phenotypes From GWAS Catalog for OC90 Gene

Gene Ontology (GO) - Molecular Function for OC90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004623 phospholipase A2 activity IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with OC90: view
genes like me logo Genes that share phenotypes with OC90: view

Animal Models for OC90 Gene

MGI Knock Outs for OC90:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OC90 Gene

Localization for OC90 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OC90 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OC90 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for OC90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OC90: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OC90 Gene

Pathways & Interactions for OC90 Gene

No Data Available

Interacting Proteins for OC90 Gene

Gene Ontology (GO) - Biological Process for OC90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IEA --
GO:0008150 biological_process ND --
GO:0016042 lipid catabolic process IEA --
GO:0050482 arachidonic acid secretion IEA --
genes like me logo Genes that share ontologies with OC90: view

No data available for Pathways by source and SIGNOR curated interactions for OC90 Gene

Drugs & Compounds for OC90 Gene

No Compound Related Data Available

Transcripts for OC90 Gene

mRNA/cDNA for OC90 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OC90 Gene

Otoconin 90:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OC90 Gene

No ASD Table

Relevant External Links for OC90 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OC90 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OC90 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OC90 Gene

This gene is overexpressed in Heart (46.3) and Adipocyte (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OC90 Gene

Protein tissue co-expression partners for OC90 Gene

NURSA nuclear receptor signaling pathways regulating expression of OC90 Gene:


SOURCE GeneReport for Unigene cluster for OC90 Gene:

genes like me logo Genes that share expression patterns with OC90: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OC90 Gene

Orthologs for OC90 Gene

This gene was present in the common ancestor of animals.

Orthologs for OC90 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OC90 33
  • 98.95 (n)
-- 34
  • 68 (a)
(Canis familiaris)
Mammalia OC90 33
  • 80.09 (n)
-- 34
  • 69 (a)
(Bos Taurus)
Mammalia OC90 33
  • 79.55 (n)
-- 34
  • 72 (a)
(Rattus norvegicus)
Mammalia LOC102546577 33
  • 78.27 (n)
(Mus musculus)
Mammalia Oc90 33 16 34
  • 77.19 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
(Gallus gallus)
Aves OC90 33
  • 60.29 (n)
-- 34
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia oc90 33
  • 59.29 (n)
(Danio rerio)
Actinopterygii CR848728.2 34
  • 16 (a)
oc90 34
  • 15 (a)
(Caenorhabditis elegans)
Secernentea C07E3.9 34
  • 24 (a)
Species where no ortholog for OC90 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OC90 Gene

Gene Tree for OC90 (if available)
Gene Tree for OC90 (if available)

Paralogs for OC90 Gene

(3) SIMAP similar genes for OC90 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OC90: view

Variants for OC90 Gene

Sequence variations from dbSNP and Humsavar for OC90 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000029084 -- 132,038,531(-) C/T intron_variant
rs1000079068 -- 132,038,500(-) A/C intron_variant
rs1000202936 -- 132,046,798(-) G/A intron_variant
rs1000251746 -- 132,029,889(-) C/T intron_variant
rs1000329299 -- 132,058,766(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OC90 Gene

Variant ID Type Subtype PubMed ID
esv2660746 CNV deletion 23128226
esv28393 CNV loss 19812545
esv3618853 CNV gain 21293372
esv3618867 CNV loss 21293372
esv3618868 CNV loss 21293372
esv3618869 CNV loss 21293372
nsv1018172 CNV gain 25217958
nsv1115138 CNV deletion 24896259
nsv517297 CNV loss 19592680
nsv517992 CNV loss 19592680
nsv612325 CNV gain 21841781
nsv612326 CNV loss 21841781

Variation tolerance for OC90 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.77; 86.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OC90 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OC90 Gene

Disorders for OC90 Gene

Additional Disease Information for OC90

No disorders were found for OC90 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OC90 Gene

Publications for OC90 Gene

  1. Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes. (PMID: 10329003) Kowalski PE … Mager DL (Genomics 1999) 2 3 58
  2. Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2. (PMID: 9860971) Wang Y … Thalmann R (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 58
  3. Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene. (PMID: 8382789) Feuchter-Murthy AE … Mager DL (Nucleic acids research 1993) 3 4 58
  4. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z … Shaffer JR (Caries research 2014) 3 58
  5. In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90. (PMID: 24748133) Moreland KT … Thalmann R (PloS one 2014) 3 58

Products for OC90 Gene

Sources for OC90 Gene

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