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Aliases for OC90 Gene

Aliases for OC90 Gene

  • Otoconin 90 2 3 5
  • Phospholipase A2 Homolog 3 4
  • PLA2L 3 4
  • Oc90 4

External Ids for OC90 Gene

Previous HGNC Symbols for OC90 Gene

  • PLA2L

Previous GeneCards Identifiers for OC90 Gene

  • GC08U990050
  • GC08M133069
  • GC08M132708
  • GC08M132993
  • GC08M133105
  • GC08M128354
  • GC08M133039

Summaries for OC90 Gene

GeneCards Summary for OC90 Gene

OC90 (Otoconin 90) is a Protein Coding gene. Diseases associated with OC90 include potter's syndrome. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2C.

UniProtKB/Swiss-Prot for OC90 Gene

  • It is unlikely that this protein has phospholipase A2 activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OC90 Gene

Genomics for OC90 Gene

Regulatory Elements for OC90 Gene

Genomic Location for OC90 Gene

Chromosome:
8
Start:
132,024,220 bp from pter
End:
132,059,380 bp from pter
Size:
35,161 bases
Orientation:
Minus strand

Genomic View for OC90 Gene

Genes around OC90 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OC90 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OC90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OC90 Gene

Proteins for OC90 Gene

  • Protein details for OC90 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02509-OC90_HUMAN
    Recommended name:
    Otoconin-90
    Protein Accession:
    Q02509
    Secondary Accessions:
    • B4DNG8

    Protein attributes for OC90 Gene

    Size:
    493 amino acids
    Molecular mass:
    53454 Da
    Quaternary structure:
    • Interacts with OTOL1.
    SequenceCaution:
    • Sequence=CAA78662.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for OC90 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OC90 Gene

Proteomics data for OC90 Gene at MOPED

Post-translational modifications for OC90 Gene

  • Glycosylation at Asn 38, Asn 179, and Asn 423
  • Modification sites at PhosphoSitePlus

Other Protein References for OC90 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OC90 Gene

Domains & Families for OC90 Gene

Protein Domains for OC90 Gene

Suggested Antigen Peptide Sequences for OC90 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02509

UniProtKB/Swiss-Prot:

OC90_HUMAN :
  • Consists of 3 PA2-type domains.
  • Belongs to the phospholipase A2 family.
Domain:
  • Consists of 3 PA2-type domains.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with OC90: view

No data available for Gene Families for OC90 Gene

Function for OC90 Gene

Molecular function for OC90 Gene

GENATLAS Biochemistry:
atoconin 90,phospholipase-A2 like secreted protein,linked to HHLA1 by intergenic splicing,homolog to a murine protein expressed in fetal inner ear
UniProtKB/Swiss-Prot Function:
It is unlikely that this protein has phospholipase A2 activity.
genes like me logo Genes that share phenotypes with OC90: view

Animal Models for OC90 Gene

MGI Knock Outs for OC90:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OC90 Gene

Localization for OC90 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OC90 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OC90 Gene COMPARTMENTS Subcellular localization image for OC90 gene
Compartment Confidence
extracellular 3
chloroplast 1

Gene Ontology (GO) - Cellular Components for OC90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OC90: view

Pathways & Interactions for OC90 Gene

SuperPathways for OC90 Gene

No Data Available

Interacting Proteins for OC90 Gene

Gene Ontology (GO) - Biological Process for OC90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with OC90: view

No data available for Pathways by source and SIGNOR curated interactions for OC90 Gene

Drugs & Compounds for OC90 Gene

No Compound Related Data Available

Transcripts for OC90 Gene

mRNA/cDNA for OC90 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OC90 Gene

Otoconin 90:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OC90 Gene

No ASD Table

Relevant External Links for OC90 Gene

GeneLoc Exon Structure for
OC90
ECgene alternative splicing isoforms for
OC90

Expression for OC90 Gene

mRNA expression in normal human tissues for OC90 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OC90 Gene

This gene is overexpressed in Heart (46.3) and Adipocyte (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OC90 Gene



SOURCE GeneReport for Unigene cluster for OC90 Gene Hs.653174

genes like me logo Genes that share expression patterns with OC90: view

Protein tissue co-expression partners for OC90 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OC90 Gene

Orthologs for OC90 Gene

This gene was present in the common ancestor of animals.

Orthologs for OC90 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OC90 35
  • 98.95 (n)
  • 98.11 (a)
-- 36
  • 68 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 72 (a)
OneToMany
OC90 35
  • 79.55 (n)
  • 73.89 (a)
dog
(Canis familiaris)
Mammalia OC90 35
  • 80.09 (n)
  • 74.27 (a)
-- 36
  • 69 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Oc90 16
Oc90 35
  • 77.19 (n)
  • 70.15 (a)
Oc90 36
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Oc90 35
  • 78.27 (n)
  • 70.28 (a)
chicken
(Gallus gallus)
Aves OC90 35
  • 60.29 (n)
  • 54.62 (a)
-- 36
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia oc90 35
  • 59.29 (n)
  • 51.67 (a)
zebrafish
(Danio rerio)
Actinopterygii CR848728.2 36
  • 16 (a)
ManyToMany
oc90 36
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C07E3.9 36
  • 24 (a)
OneToMany
Species with no ortholog for OC90:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OC90 Gene

ENSEMBL:
Gene Tree for OC90 (if available)
TreeFam:
Gene Tree for OC90 (if available)

Paralogs for OC90 Gene

(3) SIMAP similar genes for OC90 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OC90: view

Variants for OC90 Gene

Sequence variations from dbSNP and Humsavar for OC90 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs870715 -- 132,037,799(+) GACCT(A/C)TGTTC intron-variant
rs871959 -- 132,038,653(-) CCTTC(C/T)CTGGC intron-variant
rs871960 -- 132,038,529(-) GTAGA(A/C)CCCAA intron-variant
rs1472571 -- 132,036,346(-) GAAAA(A/G)GACAG intron-variant
rs1501057 -- 132,027,743(+) GGTTT(C/G)TACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OC90 Gene

Variant ID Type Subtype PubMed ID
nsv891453 CNV Gain 21882294
nsv517297 CNV Loss 19592680
nsv517992 CNV Loss 19592680
esv28393 CNV Loss 19812545
esv2660746 CNV Deletion 23128226

Variation tolerance for OC90 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.77; 86.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OC90 Gene

HapMap Linkage Disequilibrium report
OC90

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OC90 Gene

Disorders for OC90 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OC90 Gene - From: DISEASES

Disorder Aliases PubMed IDs
potter's syndrome
  • potter syndrome
- elite association - COSMIC cancer census association via MalaCards
Search OC90 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OC90

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OC90
genes like me logo Genes that share disorders with OC90: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OC90 Gene

Publications for OC90 Gene

  1. Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes. (PMID: 10329003) Kowalski P.E. … Mager D.L. (Genomics 1999) 2 3 67
  2. Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2. (PMID: 9860971) Wang Y. … Thalmann R. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  3. In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90. (PMID: 24748133) Moreland K.T. … Thalmann R. (PLoS ONE 2014) 3
  4. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z. … Shaffer J.R. (Caries Res. 2014) 3
  5. Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. (PMID: 15188402) Hassel S. … Souchelnytskyi S. (Proteomics 2004) 3

Products for OC90 Gene

Sources for OC90 Gene

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