Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OC90 Gene

Aliases for OC90 Gene

  • Otoconin 90 2 3 5
  • Phospholipase A2 Homolog 3 4
  • PLA2L 3 4
  • Otoconin-90 3
  • Oc90 4

External Ids for OC90 Gene

Previous HGNC Symbols for OC90 Gene

  • PLA2L

Previous GeneCards Identifiers for OC90 Gene

  • GC08U990050
  • GC08M133069
  • GC08M132708
  • GC08M132993
  • GC08M133105
  • GC08M128354
  • GC08M133039

Summaries for OC90 Gene

GeneCards Summary for OC90 Gene

OC90 (Otoconin 90) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is ENSG00000258417.

UniProtKB/Swiss-Prot for OC90 Gene

  • It is unlikely that this protein has phospholipase A2 activity.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OC90 Gene

Genomics for OC90 Gene

Regulatory Elements for OC90 Gene

Enhancers for OC90 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G132057 0.6 ENCODE 0.7 +1.5 1462 0.3 CTCF JUN FOSL1 CTBP1 JUND POLR2A MTA1 CREB1 FOSL2 FOS OC90 GC08M131995
GH08G132046 0.7 ENCODE 0.4 +12.4 12432 0.2 PKNOX1 RFX1 MNT DPF2 BMI1 RAD21 FOXA1 ZNF217 CTBP1 JUND OC90 GC08M131995
GH08G132045 0.4 ENCODE 0.4 +14.2 14238 0.1 POU5F1 OC90 GC08M131995
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OC90 on UCSC Golden Path with GeneCards custom track

Genomic Location for OC90 Gene

Chromosome:
8
Start:
132,024,220 bp from pter
End:
132,059,380 bp from pter
Size:
35,161 bases
Orientation:
Minus strand

Genomic View for OC90 Gene

Genes around OC90 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OC90 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OC90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OC90 Gene

Proteins for OC90 Gene

  • Protein details for OC90 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02509-OC90_HUMAN
    Recommended name:
    Otoconin-90
    Protein Accession:
    Q02509
    Secondary Accessions:
    • B4DNG8

    Protein attributes for OC90 Gene

    Size:
    493 amino acids
    Molecular mass:
    53454 Da
    Quaternary structure:
    • Interacts with OTOL1.
    SequenceCaution:
    • Sequence=CAA78662.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for OC90 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OC90 Gene

Post-translational modifications for OC90 Gene

  • Glycosylation at posLast=3838, posLast=179179, and Asn423
  • Modification sites at PhosphoSitePlus

Other Protein References for OC90 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OC90 Gene

Domains & Families for OC90 Gene

Protein Domains for OC90 Gene

Suggested Antigen Peptide Sequences for OC90 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02509

UniProtKB/Swiss-Prot:

OC90_HUMAN :
  • Consists of 3 PA2-type domains.
  • Belongs to the phospholipase A2 family.
Domain:
  • Consists of 3 PA2-type domains.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with OC90: view

No data available for Gene Families for OC90 Gene

Function for OC90 Gene

Molecular function for OC90 Gene

GENATLAS Biochemistry:
atoconin 90,phospholipase-A2 like secreted protein,linked to HHLA1 by intergenic splicing,homolog to a murine protein expressed in fetal inner ear
UniProtKB/Swiss-Prot Function:
It is unlikely that this protein has phospholipase A2 activity.

Gene Ontology (GO) - Molecular Function for OC90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004623 phospholipase A2 activity IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with OC90: view
genes like me logo Genes that share phenotypes with OC90: view

Animal Models for OC90 Gene

MGI Knock Outs for OC90:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OC90 Gene

Localization for OC90 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OC90 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OC90 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for OC90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OC90: view

Pathways & Interactions for OC90 Gene

No Data Available

Interacting Proteins for OC90 Gene

Gene Ontology (GO) - Biological Process for OC90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IEA --
GO:0008150 biological_process ND --
GO:0016042 lipid catabolic process IEA --
GO:0050482 arachidonic acid secretion IEA --
genes like me logo Genes that share ontologies with OC90: view

No data available for Pathways by source and SIGNOR curated interactions for OC90 Gene

Drugs & Compounds for OC90 Gene

No Compound Related Data Available

Transcripts for OC90 Gene

mRNA/cDNA for OC90 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OC90 Gene

Otoconin 90:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OC90 Gene

No ASD Table

Relevant External Links for OC90 Gene

GeneLoc Exon Structure for
OC90
ECgene alternative splicing isoforms for
OC90

Expression for OC90 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OC90 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OC90 Gene

This gene is overexpressed in Heart (46.3) and Adipocyte (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OC90 Gene



Protein tissue co-expression partners for OC90 Gene

NURSA nuclear receptor signaling pathways regulating expression of OC90 Gene:

OC90

SOURCE GeneReport for Unigene cluster for OC90 Gene:

Hs.653174
genes like me logo Genes that share expression patterns with OC90: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OC90 Gene

Orthologs for OC90 Gene

This gene was present in the common ancestor of animals.

Orthologs for OC90 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OC90 34
  • 98.95 (n)
-- 35
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OC90 34
  • 80.09 (n)
-- 35
  • 69 (a)
OneToMany
cow
(Bos Taurus)
Mammalia OC90 34
  • 79.55 (n)
-- 35
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC102546577 34
  • 78.27 (n)
mouse
(Mus musculus)
Mammalia Oc90 34 16 35
  • 77.19 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 48 (a)
OneToMany
chicken
(Gallus gallus)
Aves OC90 34
  • 60.29 (n)
-- 35
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia oc90 34
  • 59.29 (n)
zebrafish
(Danio rerio)
Actinopterygii CR848728.2 35
  • 16 (a)
ManyToMany
oc90 35
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C07E3.9 35
  • 24 (a)
OneToMany
Species where no ortholog for OC90 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OC90 Gene

ENSEMBL:
Gene Tree for OC90 (if available)
TreeFam:
Gene Tree for OC90 (if available)

Paralogs for OC90 Gene

(3) SIMAP similar genes for OC90 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OC90: view

Variants for OC90 Gene

Sequence variations from dbSNP and Humsavar for OC90 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000029084 -- 132,038,531(+) GGGTT(C/T)TACAT intron-variant
rs1000079068 -- 132,038,500(+) TACAG(A/C)GTGAG intron-variant
rs1000202936 -- 132,046,798(+) TAGAA(A/G)CCCCA intron-variant
rs1000251746 -- 132,029,889(+) ATACT(C/T)CCTTT intron-variant
rs1000329299 -- 132,058,766(+) TGTGT(C/T)TCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OC90 Gene

Variant ID Type Subtype PubMed ID
esv2660746 CNV deletion 23128226
esv28393 CNV loss 19812545
esv3618853 CNV gain 21293372
esv3618867 CNV loss 21293372
esv3618868 CNV loss 21293372
esv3618869 CNV loss 21293372
nsv1018172 CNV gain 25217958
nsv1115138 CNV deletion 24896259
nsv517297 CNV loss 19592680
nsv517992 CNV loss 19592680
nsv612325 CNV gain 21841781
nsv612326 CNV loss 21841781

Variation tolerance for OC90 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.77; 86.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OC90 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OC90

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OC90 Gene

Disorders for OC90 Gene

Relevant External Links for OC90

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OC90

No disorders were found for OC90 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OC90 Gene

Publications for OC90 Gene

  1. Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes. (PMID: 10329003) Kowalski P.E. … Mager D.L. (Genomics 1999) 2 3 64
  2. Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2. (PMID: 9860971) Wang Y. … Thalmann R. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 64
  3. Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene. (PMID: 8382789) Feuchter-Murthy A.E. … Mager D.L. (Nucleic Acids Res. 1993) 3 4 64
  4. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z. … Shaffer J.R. (Caries Res. 2014) 3 64
  5. In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90. (PMID: 24748133) Moreland K.T. … Thalmann R. (PLoS ONE 2014) 3 64

Products for OC90 Gene

Sources for OC90 Gene

Content
Loading form....