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Aliases & Descriptions for OBSL1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA0657 1, 2, 3, 5 | | MGC71026 2 |
| | | Descriptions |
|---|
| obscurin-like 1 2 |
|
| | Search outside databases for aliases for OBSL1 genePrevious GC identifer: GC02M220242 |
Summaries for OBSL1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for OBSL1 |
Genomic Location for OBSL1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OBSL1 gene 
Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35OBSL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M220124:
(about GC identifiers)
Start:
|
220,123,708 bp from pter |
End:
|
220,144,430 bp from pter |
Size:
|
20,723 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for OBSL1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: OBSL1_HUMAN, O75147 (See
protein sequence)Recommended Name: Obscurin-like protein 1 precursor Size: 1401 amino acids; 152883 Da
PDB structures from and Proteopedia :2CPC (3D)
 2E6P (3D)
 2E6Q (3D)
 
Secondary accessions: Q96IW3Alternative splicing: 2 isoforms: O75147-1 O75147-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056126.1
ENSEMBL proteins: ENSP00000385636 ENSP00000362983 ENSP00000265317 ENSP00000265318 ENSP00000362980 ENSP00000289656
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for OBSL1: Assays for OBSL1: | Protein
Domains/ Families for OBSL1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O75147
ProtoNet protein and cluster: O75147 1 Blocks protein family: IPB013098 Immunoglobulin I-set
UniProtKB/Swiss-Prot: OBSL1_HUMAN, O75147Similarity: Contains 1 fibronectin type-III domainSimilarity: Contains 11 Ig-like (immunoglobulin-like) domains | Gene Function for OBSL1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                  Browse Origene for 29mer shRNA kit in GFP-retroviral vector
Applied Biosystems Silencer® siRNAs for OBSL1
Sigma-Aldrich siRNA for OBSL1  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015311                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015311                                  untagged cDNA clone in CMV expression vector: NM_015311 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015311
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008093 | cytoskeletal adaptor activity |
NAS | 17289344 | About this table | Pathways & Interactions for OBSL1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for OBSL1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for OBSL1
|
Transcripts for OBSL1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                  Browse Origene for 29mer shRNA kit in GFP-retroviral vector
Sigma-Aldrich siRNA for OBSL1  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015311 REFSEQ mRNAs for OBSL1 gene: NM_015311.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015311               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015311                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015311                                  untagged cDNA clone in CMV expression vector: NM_015311  Additional cDNA sequence: AB014557.2 AF035292.1 AK023854.1 AK025946.1 AK092118.1 AK299261.1 BC007201.1 BC061909.1 CR590353.1 CR602668.1 CR607106.1 EF063637.1 EF063638.1 24 DOTS entries: DT.99963032 DT.216748 DT.405896 DT.110924 DT.91750101 DT.97846331 DT.429047 DT.87015490 DT.95312530 DT.97846329 DT.95141774 DT.95155791 DT.100704378 DT.40258328 DT.75119264 DT.91811417 DT.100791274 DT.120947791 DT.120947803 DT.40122355 DT.40267058 DT.91911246 DT.101961551 DT.120947777 24/323 AceView cDNA sequences (see all 323
):AA988591 AI368888 F05060 AW874491 N57473 AI241134 AI017836 AU141131 T16558 T32113 Z44605 AI240918 BM023354 BM014515 AL079501 BM695897 AI820653 F10891 BM799726 AU119815 AA430576 AA878785 BM725404 AI978623
highest scoring ESTs for OBSL1:AI017836 AB014557 AA219338 AF035292 AI161267 AI660388 AI802325 AI885931 AW028092 AW410057 Unigene Cluster for OBSL1: Obscurin-like 1 Hs.526594 [show with all ESTs]Unigene Representative Sequence: EF063638
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for OBSL1 (see all 17
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | - |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | · | 17c | · | 17d | · | 17e | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   |
About this scheme
ECgene alternative splicing isoforms for OBSL1
6 Ensembl transcripts including schematic representations: ENST00000404537
ENST00000373876
ENST00000265317
ENST00000265318
ENST00000373873
ENST00000289656
|
Expression for OBSL1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OBSL1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OBSL1
1 / 2 / 3 18 probe-sets matching OBSL1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.526594
Expression variation in blood from EXPOLDB for OBSL1 |
Orthologs for OBSL1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OBSL1 gene from 5 species
About this table Species with no ortholog for OBSL1
ENSEMBL Gene Tree for OBSL1 | Paralogs for OBSL1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for OBSL1 gene
- OBSCN2
|
SNPs/Variants for OBSL1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OBSL1 (up to first 250kb)
|
Disorders & Mutations for OBSL1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610991
|
Medical News for OBSL1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OBSL1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10 PubMed articles for OBSL1 gene:- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)2, 3, 4 Ishikawa K....Ohara O. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)3, 4 Nakajima D.... Nagase T. (2002)
- Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. (PubMed id 17289344)1, 3 Geisler S.B.... Russell M.W. (2007)
- Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies. (PubMed id 18477606)1, 3 Fukuzawa A....Gautel M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)3 Yu W....Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)3 Andersson B....Gibbs R.A. (1996)
|
Search for OBSL1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OBSL1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OBSL1
(According to HUGE)
About This Section
| |
Specialized Databases showing OBSL1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for OBSL1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OBSL1:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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