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OBSCN Gene

protein-coding GIFtS: 51

GC01P226462

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp666E245 ^²
EC 2.7.11.1 ^³
FLJ14124 ^²
KIAA1556 ^¹, ², ³
KIAA1639 ^¹, ², ³
MGC120409 ^²
MGC120410 ^²
MGC120411 ^²
MGC120412 ^²
MGC138590 ^²
Obscurin-MLCK ^³
Obscurin-RhoGEF ^³
UNC89 ^¹, ²
obscurin-MLCK ^²
obscurin-RhoGEF ^²

Descriptions
Obscurin-myosin light chain kinase ^³
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF ^²
obscurin, myosin light chain kinase ^²

External Ids
HGNC: 15719¹
Entrez Gene: 84033²
UniProtKB: Q5VST9³
Ensembl: ENSG00000154358⁷

Search outside databases for aliases for OBSCN gene

Previous GC identifers: GC01P226893 GC01M224138 GC01P224855 GC01P225370 GC01P224702

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OBSCN:

The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of

approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1

calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2

serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling

proteins that includes titin and nebulin, and may have a role in the organization of myofibrils

during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils.

Alternatively spliced transcript variants encoding different isoforms have been identified.

[provided by RefSeq]

UniProtKB/Swiss-Prot: OBSCN_HUMAN, Q5VST9

Function: Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into

sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may

provide a molecular link between the sarcoplasmic reticulum and myofibrils

Gene Wiki entry for OBSCN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OBSCN gene

Entrez Gene cytogenetic band: 1q42.13 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q42

OBSCN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P226462: (about GC identifiers)

Start:	226,462,484 bp from pter
End:	226,633,198 bp from pter
Size:	170,715 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004559.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OBSCN_HUMAN, Q5VST9 (See protein sequence)

Recommended Name: Obscurin

Size: 7968 amino acids; 868484 Da

Cofactor: Magnesium (By similarity)

Subunit: Isoform 3 interacts with TTN/titin, ANK1 isoform Mu17/ank1.5, and with calmodulin in a

Ca(2+)-independent manner. Associates with fast skeletal muscle myosin (By similarity)

Subcellular location: Isoform 3: Cytoplasm, myofibril, sarcomere, M-band. Cytoplasm, myofibril,

sarcomere, Z-disk. Note=In differentiating skeletal muscle cells, isoform 3 primarily localizes to

the sarcomeric M-line and less frequently to the Z-disk. Isoform 3 colocalizes with ANK1 isoform

Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells

Caution: Initially the name obscurin was used to describe isoform 3 which lacks the kinase domains

Sequence caution: Sequence=CAC85746.1; Type=Erroneous gene model prediction; Sequence=CAC85749.1;

Type=Erroneous gene model prediction; Sequence=CAC85750.1; Type=Erroneous gene model prediction;

Sequence=CAH71670.2; Type=Erroneous gene model prediction; Sequence=CAI19283.1; Type=Erroneous

gene model prediction; Sequence=CAI19284.1; Type=Erroneous gene model prediction;

PDB structures from and Proteopedia :

1V1C (3D)

2CR6 (3D)

2DKU (3D)

2DM7 (3D)

2E7B (3D)

2EDF (3D)

2EDH (3D)

2EDL (3D)

2EDQ (3D)

2EDR (3D)

2EDT (3D)

2EDW (3D)

2ENY (3D)

2EO1 (3D)

2GQH (3D)

2YZ8 (3D)

Secondary accessions: Q2A664 Q5T7G8 Q5T7G9 Q5VSU2 Q86YC7 Q8NHN0 Q8NHN1 Q8NHN2 Q8NHN3 Q8NHN4 Q8NHN5

Q8NHN6 Q8NHN7 Q8NHN8 Q8NHN9 Q96AA2 Q9HCD3 Q9HCL6

Alternative splicing: 6 isoforms: Q5VST9-1 Q5VST9-2 Q5VST9-3 Q5VST9-4 Q5VST9-5 Q5VST9-6 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001092093.1 NP_443075.2

ENSEMBL proteins:

ENSP00000355670 ENSP00000284548 ENSP00000352613 ENSP00000355667 ENSP00000355668 ENSP00000355665

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (OBSCN)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0030016	myofibril	NAS	11717165
GO:0030018	Z disc	ISS	11717165
GO:0031430	M band	ISS	11717165

About this table

Antibodies for OBSCN:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for OBSCN
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OBSCN

Assays for OBSCN:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q5VST9

ProtoNet protein and cluster: Q5VST9

3 Blocks protein families:

IPB000219 DH domain

IPB003598 Immunoglobulin C-2 type

IPB013098 Immunoglobulin I-set

UniProtKB/Swiss-Prot: OBSCN_HUMAN, Q5VST9

Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 3 fibronectin type-III domains

Similarity: Contains 55 Ig-like (immunoglobulin-like) domains

Similarity: Contains 1 IQ domain

Similarity: Contains 2 PH domains

Similarity: Contains 2 protein kinase domains

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OBSCN)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_052843

Applied Biosystems Silencer® siRNAs for OBSCN

Sigma-Aldrich siRNA and siRNA Panels for OBSCN

Sigma-Aldrich shRNA Panels and shRNA for OBSCN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_052843
Myc/DDK tagged cDNA clone in CMV expression vector: NM_052843
untagged cDNA clone in CMV expression vector: NM_052843

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001098623

UniProtKB/Swiss-Prot: OBSCN_HUMAN, Q5VST9

Function: Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into

sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may

provide a molecular link between the sarcoplasmic reticulum and myofibrils

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005515	protein binding	IPI	11448995 12527750

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for OBSCN

5/92 Interacting proteins for OBSCN (ENSP00000355670³ Q5VST9^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 92 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ANK2	Q01484-2¹	STRING (score=.816) MINT-50081 EBI-941921, EBI-941994
TTN	Q8WZ42¹	STRING (score=.924) EBI-941850, EBI-681210
ANK1	P16157²	STRING (score=.997) MINT-50079 MINT-50077 MINT-50078 MINT-50080 MINT-50083
CALM1	P62158¹	EBI-941850, EBI-397435
RHOQ	ENSP00000238738³	STRING (score=.99)
CDC42P2	ENSP00000314458³	STRING (score=.922)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0030154	cell differentiation	IEA	--
GO:0035023	regulation of Rho protein signal transduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OBSCN

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OBSCN)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_052843

Sigma-Aldrich siRNA and siRNA Panels for OBSCN

Sigma-Aldrich shRNA Panels and shRNA for OBSCN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001098623 NM_052843

REFSEQ mRNAs for OBSCN gene (2 alternative transcripts):

NM_001098623.1 NM_052843.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001098623 NM_052843

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_052843
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_052843
                                 untagged cDNA clone in CMV expression vector: NM_052843

Additional cDNA sequence:

AB046776.1 AB046859.2 AJ002535.1 AK097489.1 AK294019.1 AL832357.1 AL833724.1 AM231061.1

BC034746.1 BC098118.1 BC098262.1 BC098292.1 BC099731.1 BC114382.1 BC114461.1 DQ400343.1

17 DOTS entries:

DT.309204 DT.91660234 DT.40192867 DT.100019129 DT.432103 DT.95070233 DT.91742598 DT.75132836

DT.92068659 DT.97813424 DT.121379161 DT.40235496 DT.91941546 DT.95370775 DT.101962611 DT.91833941

DT.91961510

24/66 AceView cDNA sequences (see all 66 ):

CA391927 BM984363 BE466441 BC034746 CD674219 BQ001756 CA430292 BC043916

BX279955 CA396562 BQ446463 AL080128 CK299696 F28086 BM551034 AI080136

AL833724 AK097489 CA391926 BE731455 AI889172 NM_052843 F24617 BQ006643

highest scoring ESTs for OBSCN:

AA211445 AA211502 AI080136 AI128717 AI862904 AJ571824 AJ573009 AJ573143 AJ574393 AL832357

Unigene Cluster for OBSCN:

Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Hs.656999 [show with all ESTs]

Unigene Representative Sequence: NM_001098623

GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations:

ENST00000366709 ENST00000284548 ENST00000359599 ENST00000366706 ENST00000366707 ENST00000366704

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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OBSCN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OBSCN

¹ / ² / ³

9 probe-sets matching OBSCN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
89875_at²^{, 3}	U95-E	1	1.00	1.00	0.97	1.02	AA211445	1.00	0.90	0.95	1
68702_at²^{, 3}	U95-D	1	0.88	1.00	-0.12	0.99	AI672719	0.60	0.83	0.73	1
61513_at*²^{, 3}	U95-C	1	--	--	0.26	0.22	AA781170	0.20	1.00	0.72	1
233029_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB046859	0.60	0.50	0.55	1
229854_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW614056	0.60	0.83	0.73	1
220427_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
233029_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229854_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220427_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks OBSCN for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGAGCGCCG

SOURCE GeneReport for Unigene cluster: Hs.656999

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OBSCN gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	OBSCN¹	--	obscurin, cytoskeletal calmodulin and titin-interacting more	94.84(n) 93.59(a)	457798 XM_514255.2 XP_514255.2
cow (Bos taurus)	OBSCN¹	--	obscurin, cytoskeletal calmodulin and titin-interacting more	82.87(n) 81.56(a)	516942 XM_595102.3 XP_595102.3
rat (Rattus norvegicus)	Obscn¹	--	obscurin, cytoskeletal calmodulin and titin-interacting more	80.21(n) 79.94(a)	338458 XM_340807.3 XP_340808.3
chicken (Gallus gallus)	OBSCN¹	--	obscurin, cytoskeletal calmodulin and titin-interacting more	62.17(n) 57.17(a)	420395 XM_418501.2 XP_418501.2

About this table Species with no ortholog for OBSCN

ENSEMBL Gene Tree for OBSCN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OBSCN gene

OBSL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1043 NCBI SNPs in OBSCN are shown (see all 1043 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 322)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs500049^1,2	A,C,F,H,O	226626617(-)	`TGGTCA/GCCTGT`	1	A/V	mis¹ ese³		11	MN NA EU EA WA	1080
	rs4653942^1,2	A,C,F,H	226571827(+)	`GGCTCG/ACAGCA`	2	H/R	mis¹ ese³		4	EU EA WA	416
	rs4653947^1,2	A,C,F,H	226616032(+)	`GGAGTG/AAGGAG`	2	--	int¹ ng3¹		7	NA EU EA WA	560
	rs435776^1,2	A,C,F,H	226561413(-)	`CACTCC/TGCGTA`	2	G/R	mis¹ ese³		6	NA EU EA WA	476
	rs1188697^1,2	A,C,F,H	226535081(-)	`GCCCAC/TGTGGC`	2	V/M	mis¹ ese³		4	EU EA WA	406
	rs1771487^1,2	A,C,F,H	226468744(-)	`AGAACC/TGGGTG`	2	Q/R	mis¹ ese³		7	NA EA EU WA	1954
	rs1188729^1,2	A,C,F,H	226572291(+)	`TGTCTG/CTCTGG`	2	C/S	mis¹ ese³		11	EU EA WA NA	2198
	rs7532924^1,2	A,C,F,H	226460552(+)	`TGGCCA/CGCACA`	2	--	ng5¹		4	EU EA WA	414
	rs369909^1,2	A,C,F,H	226587596(-)	`CTGGAG/CGTCTC`	2	V/L	mis¹ ese³		7	EU EA WA NA	1732
	rs1188710^1,2	A,C,F,H	226595186(-)	`GGCCTC/GCAGGG`	2	Q/E	mis¹ ese³		4	EU EA WA	412

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HapMap Linkage Disequilibrium images for OBSCN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608616

Human Gene Mutation Database: OBSCN

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/23 PubMed articles for OBSCN gene (see all 23 ):

Identification, tissue expression and chromosomal localization of human Obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases. (PubMed id 11814696)^{1, 2, 3, 4} Russell M.W....Sonneman K.J. (2002)
Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. (PubMed id 11448995)^{2, 3, 4} Young P.W.... Gautel M. (2001)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing. (PubMed id 16205939)^{3, 4} Borisov A.B.... Russell M.W. (2006)
Complete human gene structure of obscurin: implications for isoform generation by differential splicing. (PubMed id 16625316)^{3, 4} Fukuzawa A.... Gautel M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles. (PubMed id 12527750)^{3, 4} Bagnato P.... Sorrentino V. (2003)
The complete gene sequence of titin, expression of an unusual ~700 kDa titin isoform and its interaction with obscurin identify a novel Z-line to I-band linking system. (PubMed id 11717165)^{3, 4} Bang M.-L....Labeit S. (2001)
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{3, 4} Nagase T....Ohara O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 84033	HGNC: 15719	AceView: OBSCN	Ensembl:ENSG00000154358	euGenes: HUgn84033
ECgene: OBSCN	H-InvDB: OBSCN

(According to HUGE)
About This Section

HUGE: KIAA1556 KIAA1639

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for OBSCN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OBSCN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OBSCN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OBSCN		Antibodies for OBSCN
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OBSCN		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (OBSCN)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

Search OriGene for OBSCN

Search Tocris compounds for OBSCN

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for OBSCN

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
OBSCN Gene at Home site.
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OBSCN Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for OBSCN

Summaries
for OBSCN

Genomic Location
for OBSCN

Proteins
for OBSCN

Protein Domains/
Families
for OBSCN

Gene Function
for OBSCN

Pathways & Interactions
for OBSCN

Drugs & Compounds
for OBSCN

Transcripts
for OBSCN

Expression
for OBSCN

Orthologs
for OBSCN

Paralogs
for OBSCN

SNPs/Variants
for OBSCN

Disorders & Mutations
for OBSCN

Medical News
for OBSCN

Publications
for OBSCN

Search for OBSCN

Genome Databases showing OBSCN

Other Databases showing OBSCN

Specialized Databases showing OBSCN

Licensable Technologies
for OBSCN

Services
for OBSCN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OBSCN Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor OBSCN

Summariesfor OBSCN

Genomic Locationfor OBSCN

Proteinsfor OBSCN

Protein Domains/Familiesfor OBSCN

Gene Functionfor OBSCN

Pathways & Interactionsfor OBSCN

Drugs & Compoundsfor OBSCN

Transcriptsfor OBSCN

Expression for OBSCN

Orthologsfor OBSCN

Paralogsfor OBSCN

SNPs/Variantsfor OBSCN

Disorders & Mutationsfor OBSCN

Medical Newsfor OBSCN

Publicationsfor OBSCN

Search for OBSCN

Genome Databases showing OBSCN

Other Databases showing OBSCN

Specialized Databases showing OBSCN

Licensable Technologiesfor OBSCN

Servicesfor OBSCN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OBSCN

Summaries
for OBSCN

Genomic Location
for OBSCN

Proteins
for OBSCN

Protein Domains/
Families
for OBSCN

Gene Function
for OBSCN

Pathways & Interactions
for OBSCN

Drugs & Compounds
for OBSCN

Transcripts
for OBSCN

Expression
for OBSCN

Orthologs
for OBSCN

Paralogs
for OBSCN

SNPs/Variants
for OBSCN

Disorders & Mutations
for OBSCN

Medical News
for OBSCN

Publications
for OBSCN

Licensable Technologies
for OBSCN

Services
for OBSCN