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OBP2B Gene

protein-coding GIFtS: 41

GC09M135070

odorant binding protein 2B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC119022 ^²
OBPIIb ^³
OTTHUMP00000022463 ^²
hOBPIIb ^¹, ²

Descriptions
odorant binding protein 2B ^²
odorant-binding protein 2B ^²

External Ids
HGNC: 23381¹
Entrez Gene: 29989²
UniProtKB: Q9NPH6³
Ensembl: ENSG00000171102⁷

Search outside databases for aliases for OBP2B gene

Previous GC identifers: GC09P127182 GC09M127637 GC09M129434 GC09M131356 GC09M133110

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: OBP2B_HUMAN, Q9NPH6

Function: Probably binds and transports small hydrophobic volatile molecules

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OBP2B gene

Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q34

OBP2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M135070: (about GC identifiers)

Start:	135,070,487 bp from pter
End:	135,074,451 bp from pter
Size:	3,965 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_035014.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OBP2B_HUMAN, Q9NPH6 (See protein sequence)

Recommended Name: Odorant-binding protein 2b precursor

Size: 170 amino acids; 19457 Da

Subcellular location: Secreted (Probable)

Secondary accessions: Q5VSP6 Q9NY51 Q9NY52

Alternative splicing: 3 isoforms: Q9NPH6-1 Q9NPH6-2 Q9NPH6-3

REFSEQ proteins: NP_055396.1

ENSEMBL proteins:

ENSP00000361104 ENSP00000361103 ENSP00000361102

Human Recombinant Proteins

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1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

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Antibodies for OBP2B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OBP2B

Assays for OBP2B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9NPH6

ProtoNet protein and cluster: Q9NPH6

2 Blocks protein families:

IPB002345 Lipocalin signature

IPB002450 Von Ebner's gland protein signature

UniProtKB/Swiss-Prot: OBP2B_HUMAN, Q9NPH6

Similarity: Belongs to the calycin superfamily. Lipocalin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OBP2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014581

Applied Biosystems Silencer® siRNAs for OBP2B

Sigma-Aldrich siRNA for OBP2B

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014581
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014581
untagged cDNA clone in CMV expression vector: NM_014581

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014581

UniProtKB/Swiss-Prot: OBP2B_HUMAN, Q9NPH6

Function: Probably binds and transports small hydrophobic volatile molecules

Genatlas biochemistry entry for OBP2B:

odorant binding protein 2B,expressed in genital sphere organs (prostate,mammary glands,deferents

ducts) and placenta member of the lipocalin family,of small extracellular proteins outlier group

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0005549	odorant binding	NAS	10607840

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0007608	sensory perception of smell	NAS	10607840
GO:0007635	chemosensory behavior	TAS	10607840
GO:0050896	response to stimulus	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OBP2B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OBP2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014581

Sigma-Aldrich siRNA for OBP2B

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014581

REFSEQ mRNAs for OBP2B gene:

NM_014581.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014581

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014581
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014581
                                 untagged cDNA clone in CMV expression vector: NM_014581

Additional cDNA sequence:

AJ251026.1 AJ251027.1 AJ251028.1 AY358981.1 BC096717.1 BC098125.1 BC098151.1 BC098340.1

1 DOTS entry:

DT.407483

20 AceView cDNA sequences:

AI143970 BV204658 AY358981 AJ251027 BV204653 AJ251026 BV204652 NM_014581

BV204657 AI251747 AJ251028 AA460323 BV204651 BV204655 AA460385 BV204654

BX101545 AA977608 BV202087 AW513637

highest scoring ESTs for OBP2B:

AJ251027 AJ251028 BC096717 BC098125 BC098151 BC098340 AJ251026 AY358981 AA977608 AA460323

Unigene Cluster for OBP2B:

Odorant binding protein 2B

Hs.449629 [show with all ESTs]

Unigene Representative Sequence: BC098340

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000372034 ENST00000372033 ENST00000372032

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OBP2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OBP2B

¹ / ² / ³

11 probe-sets matching OBP2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54812_r_at²^{, 3}	U95-C	2	1.00	0.50	1.00	1.00	AA977608	0.60	0.62	0.61	1
234722_x_at²^{, 3}	U133-B	2	1.00	0.73	--	--	AJ251027	0.80	1.00	0.91	1
233860_s_at²^{, 3}	U133-B	2	1.00	0.50	--	--	AI143970	0.40	0.67	0.55	1
220959_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	NM_014581	0.40	0.67	0.55	1
220848_x_at²	U133-A	3	0.91	0.44	--	--	--	--	--	--	--
234436_x_at²	U133-B	2	0.82	0.41	--	--	--	--	--	--	--
234722_x_at²	U133Plus2	2	1.00	0.73	--	--	--	--	--	--	--
233860_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
220959_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
220848_x_at²	U133Plus2	3	0.91	0.44	--	--	--	--	--	--	--
234436_x_at²	U133Plus2	2	0.82	0.41	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.449629
UniProtKB/Swiss-Prot: OBP2B_HUMAN, Q9NPH6
Tissue specificity: Strongly expressed in genital sphere organs such as the prostate and mammary
glands

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OBP2B gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	OBP2B¹	--	odorant binding protein 2B	98.04(n) 95.29(a)	744711 XM_001169208.1 XP_001169208.1
cow (Bos taurus)	OBP2B¹	--	odorant binding protein 2B	73.78(n) 60.98(a)	618559 XM_870888.2 XP_875981.2
rat (Rattus norvegicus)	Lcn13¹	--	lipocalin 13	61.34(n) 46.75(a)	680754 XM_001058733.1 XP_001058733.1
mouse (Mus musculus)	Lcn13¹	--	lipocalin 13	60.08(n) 42.51(a)	227627 NM_153558.1 NP_705786.1

About this table Species with no ortholog for OBP2B

ENSEMBL Gene Tree for OBP2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OBP2B gene

OBP2A² LCN1² LCN1L1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/73 NCBI SNPs in OBP2B are shown (see all 73 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 20)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs12554449^1,2	A,C,F,H	135075021(+)	`CTATTG/TTGTGG`	1	--	ng3¹		11		NA EU EA WA	972
--	rs4489379^1,2	A,C,F,H	135074762(-)	`ATCCCG/AAGGCT`	1	--	ng3¹ tfbs³		4		EU EA WA	418
--	rs3761821^1,2	A,C,F,H	135075604(+)	`GCTGGC/TGTGAC`	1	--	ng3¹ tfbs³		5		EA EU WA	1898
	rs17150306^1,2	C,F,H	135076443(+)	`TGAATC/GTCAGT`	1	--	ng3¹		11		NA EU EA WA	980
	rs3761822^1,2	A,C,F	135075644(+)	`CTGCCA/GAGCAG`	1	--	ng3¹		1		EA	1284
--	rs12379461^1,2	A,F,H	135070357(+)	`ACATCA/GTGCCT`	1	--	ng5¹		4		EU EA WA	420
--	rs11244035^1,2	C,F	135071140(+)	`GGGAAC/TGCAGC`	1	V/I	mis¹ ese³		3		NA	140
--	rs10901246^1,2	A,C	135070306(+)	`GCTCTG/TCCGGA`	1	--	ng5¹		0	--	--	--	--
--	rs10901247^1,2	A,C	135070308(+)	`TCTTCA/CGGAGG`	1	--	ng5¹		0	--	--	--	--
--	rs11244034^1,2	A,C	135070093(+)	`AGCGCC/TCCTCT`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for OBP2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604606

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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7 PubMed articles for OBP2B gene:

DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres. (PubMed id 10607840)^{3, 4} Lacazette E.... Pitiot G. (2000)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties. (PubMed id 12044155)³ Briand L....Pernollet J.C. (2002)
Molecular cloning of odorant-binding protein: member of a ligand carrier family. (PubMed id 3388043)³ Pevsner J....Snyder S.H. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 29989	HGNC: 23381	AceView: OBP2B	Ensembl:ENSG00000171102	euGenes: HUgn29989
ECgene: OBP2B	H-InvDB: OBP2B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for OBP2B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for OBP2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OBP2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OBP2B		Browse antibodies at Sigma-Aldrich
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	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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OBP2B Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for OBP2B

Summaries
for OBP2B

Genomic Location
for OBP2B

Proteins
for OBP2B

Protein Domains/
Families
for OBP2B

Gene Function
for OBP2B

Pathways & Interactions
for OBP2B

Drugs & Compounds
for OBP2B

Transcripts
for OBP2B

Expression
for OBP2B

Orthologs
for OBP2B

Paralogs
for OBP2B

SNPs/Variants
for OBP2B

Disorders & Mutations
for OBP2B

Medical News
for OBP2B

Publications
for OBP2B

Search for OBP2B

Genome Databases showing OBP2B

Other Databases showing OBP2B

Specialized Databases showing OBP2B

Licensable Technologies
for OBP2B

Services
for OBP2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OBP2B Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor OBP2B

Summariesfor OBP2B

Genomic Locationfor OBP2B

Proteinsfor OBP2B

Protein Domains/Familiesfor OBP2B

Gene Functionfor OBP2B

Pathways & Interactionsfor OBP2B

Drugs & Compoundsfor OBP2B

Transcriptsfor OBP2B

Expression for OBP2B

Orthologsfor OBP2B

Paralogsfor OBP2B

SNPs/Variantsfor OBP2B

Disorders & Mutationsfor OBP2B

Medical Newsfor OBP2B

Publicationsfor OBP2B

Search for OBP2B

Genome Databases showing OBP2B

Other Databases showing OBP2B

Specialized Databases showing OBP2B

Licensable Technologiesfor OBP2B

Servicesfor OBP2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OBP2B

Summaries
for OBP2B

Genomic Location
for OBP2B

Proteins
for OBP2B

Protein Domains/
Families
for OBP2B

Gene Function
for OBP2B

Pathways & Interactions
for OBP2B

Drugs & Compounds
for OBP2B

Transcripts
for OBP2B

Expression
for OBP2B

Orthologs
for OBP2B

Paralogs
for OBP2B

SNPs/Variants
for OBP2B

Disorders & Mutations
for OBP2B

Medical News
for OBP2B

Publications
for OBP2B

Licensable Technologies
for OBP2B

Services
for OBP2B