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Aliases for OBP2B Gene

Aliases for OBP2B Gene

  • Odorant Binding Protein 2B 2 3 5
  • Odorant-Binding Protein IIb 3 4
  • OBPIIb 3 4
  • Odorant-Binding Protein 2b 3
  • LCN14 3

External Ids for OBP2B Gene

Previous GeneCards Identifiers for OBP2B Gene

  • GC09P127182
  • GC09M127637
  • GC09M129434
  • GC09M131356
  • GC09M133110
  • GC09M135070
  • GC09M136080
  • GC09M105573

Summaries for OBP2B Gene

GeneCards Summary for OBP2B Gene

OBP2B (Odorant Binding Protein 2B) is a Protein Coding gene. GO annotations related to this gene include odorant binding. An important paralog of this gene is OBP2A.

UniProtKB/Swiss-Prot for OBP2B Gene

  • Probably binds and transports small hydrophobic volatile molecules.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OBP2B Gene

Genomics for OBP2B Gene

Regulatory Elements for OBP2B Gene

Enhancers for OBP2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F133236 1 Ensembl ENCODE 13.5 +15.1 15093 3.4 HDGF ATF1 PKNOX1 ARID4B SIN3A ZNF2 ZNF121 GLIS2 ZNF143 KLF13 ABO SETX OBP2B EEF1A1P5 ENSG00000224992 LCN1P1
GH09F133199 0.5 Ensembl ENCODE 6.4 +53.4 53425 1.5 ZNF263 CTCF POLR2A GABPB1 MAX ZBTB33 OBP2B LOC101928193 LCN1P1
GH09F132990 0.2 ENCODE 4.7 +261.4 261449 2.1 BCOR SMARCA5 ESRRA ZMYM3 MAX CBX1 HDAC2 ADNP KDM1A ZNF24 OBP2B GC09P132965 GC09P133045 GC09P133069 GC09P133080 GC09P133081
GH09F132994 0.8 Ensembl ENCODE 4.6 +258.6 258597 1.2 HDGF HDAC1 ATF1 CBX3 TBL1XR1 GATA2 SCRT2 FOS CREM ZBTB2 RNU7-21P RPL39P24 GTF3C4 TSC1 SETX GTF3C5 OBP2B GC09P133045 GC09P133069 GC09P133080
GH09F133250 0.9 Ensembl ENCODE 0.8 +1.5 1473 3.2 KLF1 PKNOX1 KLF17 MAX ZFHX2 CTBP1 POLR2A ZNF366 TCF7L2 RFX1 ABO LCN1P1 SURF6 ENSG00000201451 ENSG00000230064 ADAMTS13 SURF1 OBP2B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OBP2B on UCSC Golden Path with GeneCards custom track

Genomic Location for OBP2B Gene

Chromosome:
9
Start:
133,205,277 bp from pter
End:
133,253,397 bp from pter
Size:
48,121 bases
Orientation:
Minus strand

Genomic View for OBP2B Gene

Genes around OBP2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OBP2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OBP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OBP2B Gene

Proteins for OBP2B Gene

  • Protein details for OBP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPH6-OBP2B_HUMAN
    Recommended name:
    Odorant-binding protein 2b
    Protein Accession:
    Q9NPH6
    Secondary Accessions:
    • Q5VSP6
    • Q9NY51
    • Q9NY52

    Protein attributes for OBP2B Gene

    Size:
    170 amino acids
    Molecular mass:
    19457 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OBP2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OBP2B Gene

Post-translational modifications for OBP2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OBP2B Gene

No data available for DME Specific Peptides for OBP2B Gene

Domains & Families for OBP2B Gene

Gene Families for OBP2B Gene

Suggested Antigen Peptide Sequences for OBP2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPH6

UniProtKB/Swiss-Prot:

OBP2B_HUMAN :
  • Belongs to the calycin superfamily. Lipocalin family.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with OBP2B: view

Function for OBP2B Gene

Molecular function for OBP2B Gene

GENATLAS Biochemistry:
odorant binding protein 2B,expressed in genital sphere organs (prostate,mammary glands,deferents ducts) and placenta member of the lipocalin family,of small extracellular proteins outlier group
UniProtKB/Swiss-Prot Function:
Probably binds and transports small hydrophobic volatile molecules.

Gene Ontology (GO) - Molecular Function for OBP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding NAS 10607840
genes like me logo Genes that share ontologies with OBP2B: view
genes like me logo Genes that share phenotypes with OBP2B: view

Animal Models for OBP2B Gene

MGI Knock Outs for OBP2B:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OBP2B Gene

Localization for OBP2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for OBP2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OBP2B Gene COMPARTMENTS Subcellular localization image for OBP2B gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for OBP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OBP2B: view

Pathways & Interactions for OBP2B Gene

SuperPathways for OBP2B Gene

No Data Available

Interacting Proteins for OBP2B Gene

Selected Interacting proteins: Q9NPH6-OBP2B_HUMAN for OBP2B Gene via IID

Gene Ontology (GO) - Biological Process for OBP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007608 sensory perception of smell NAS 10607840
GO:0007635 chemosensory behavior TAS 10607840
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OBP2B: view

No data available for Pathways by source and SIGNOR curated interactions for OBP2B Gene

Transcripts for OBP2B Gene

Unigene Clusters for OBP2B Gene

Odorant binding protein 2B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OBP2B Gene

No ASD Table

Relevant External Links for OBP2B Gene

GeneLoc Exon Structure for
OBP2B
ECgene alternative splicing isoforms for
OBP2B

Expression for OBP2B Gene

mRNA expression in normal human tissues for OBP2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OBP2B Gene

This gene is overexpressed in Testis (x20.4), Skin - Not Sun Exposed (Suprapubic) (x10.2), Skin - Sun Exposed (Lower leg) (x7.5), and Breast - Mammary Tissue (x7.0).

Protein differential expression in normal tissues from HIPED for OBP2B Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OBP2B Gene



Protein tissue co-expression partners for OBP2B Gene

NURSA nuclear receptor signaling pathways regulating expression of OBP2B Gene:

OBP2B

SOURCE GeneReport for Unigene cluster for OBP2B Gene:

Hs.449629

mRNA Expression by UniProt/SwissProt for OBP2B Gene:

Q9NPH6-OBP2B_HUMAN
Tissue specificity: Strongly expressed in genital sphere organs such as the prostate and mammary glands.
genes like me logo Genes that share expression patterns with OBP2B: view

Primer Products

Orthologs for OBP2B Gene

This gene was present in the common ancestor of mammals.

Orthologs for OBP2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OBP2B 34
  • 96.27 (n)
cow
(Bos Taurus)
Mammalia LOC618559 34
  • 73.64 (n)
-- 35
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Obp2a 34
  • 62.33 (n)
mouse
(Mus musculus)
Mammalia Obp2a 34 16 35
  • 59.88 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 31 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 27 (a)
OneToMany
Species where no ortholog for OBP2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OBP2B Gene

ENSEMBL:
Gene Tree for OBP2B (if available)
TreeFam:
Gene Tree for OBP2B (if available)

Paralogs for OBP2B Gene

Paralogs for OBP2B Gene

(4) SIMAP similar genes for OBP2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OBP2B: view

Variants for OBP2B Gene

Sequence variations from dbSNP and Humsavar for OBP2B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1052517 -- 133,205,359(-) GAGCC(C/T)GGACC nc-transcript-variant, utr-variant-3-prime
rs10736860 -- 133,216,422(+) GATCA(C/T)ACTGA intron-variant
rs10751501 -- 133,216,255(+) TAGAA(C/T)GTAAA intron-variant
rs10793957 -- 133,212,544(+) TCAGA(G/T)GCTTG intron-variant
rs10793958 -- 133,212,660(+) GCGTG(A/G)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OBP2B Gene

Variant ID Type Subtype PubMed ID
dgv12930n54 CNV gain 21841781
dgv951n27 CNV gain 19166990
esv2739138 CNV deletion 23290073
esv2739155 CNV deletion 23290073
nsv469905 CNV gain 18288195
nsv6748 CNV insertion 18451855

Variation tolerance for OBP2B Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OBP2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OBP2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OBP2B Gene

Disorders for OBP2B Gene

Relevant External Links for OBP2B

Genetic Association Database (GAD)
OBP2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OBP2B

No disorders were found for OBP2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OBP2B Gene

Publications for OBP2B Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres. (PMID: 10607840) Lacazette E. … Pitiot G. (Hum. Mol. Genet. 2000) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for OBP2B Gene

Sources for OBP2B Gene

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