OBP2B Gene
protein-coding GIFtS: 45
GCID: GC09M136080
|
|
odorant binding protein 2B
| |
Aliases
for OBP2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Odorant Binding Protein 2B1 2 | | HOBPIIb1 | | Odorant-Binding Protein IIb2 3 | | OBPIIb2 3 | | Odorant-Binding Protein 2b2 |
Export aliases for OBP2B gene to outside databasesPrevious GC identifers: GC09P127182 GC09M127637 GC09M129434 GC09M131356 GC09M133110 GC09M135070 GC09M105573 |
Summaries
for OBP2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: OBP2B_HUMAN, Q9NPH6Function: Probably binds and transports small hydrophobic volatile molecules
|
Genomic Views
for OBP2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_035014.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OBP2B gene promoter:
Max1 POU2F1 GATA-3 POU2F1a MyoD TGIF GATA-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for OBP2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OBP2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q34OBP2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M136080: view genomic region
(about GC identifiers)
Start:
|
136,080,664 bp from pter |
End:
|
136,084,630 bp from pter |
Size:
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3,967 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr9-,PATCHES 136,075,459-136,079,421 |
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Proteins
for OBP2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OBP2B_HUMAN, Q9NPH6 (See
protein sequence)Recommended Name: Odorant-binding protein 2b precursor Size: 170 amino acids; 19457 Da
Subcellular location: Secreted (Probable)
Secondary accessions: Q5VSP6 Q9NY51 Q9NY52Alternative splicing: 3 isoforms: Q9NPH6-1 Q9NPH6-2 Q9NPH6-3 Explore the universe of human proteins at neXtProt for OBP2B: NX_Q9NPH6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NPH6
OBP2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055396.1
ENSEMBL proteins: ENSP00000361104 ENSP00000434927 ENSP00000361102
Human Recombinant Protein Products for OBP2B:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005576 | extracellular region |
IEA | -- |
OBP2B for ontologies About GeneDecksing
OBP2B Antibody Products:
Assay Products for OBP2B: |
Protein
Domains /
Families
for OBP2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OBP2B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NPH6ProtoNet protein and cluster: Q9NPH6 2 Blocks protein families: IPB002345 Lipocalin signature IPB002450 Von Ebner's gland protein signature
UniProtKB/Swiss-Prot: OBP2B_HUMAN, Q9NPH6Similarity: Belongs to the calycin superfamily. Lipocalin family |
Function
for OBP2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: OBP2B_HUMAN, Q9NPH6Function: Probably binds and transports small hydrophobic volatile molecules Genatlas biochemistry entry for OBP2B:odorant binding protein 2B,expressed in genital sphere organs (prostate,mammary glands,deferents ducts) and placentamember of the lipocalin family,of small extracellular proteins outlier group
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
OBP2B for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for OBP2B:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OBP2B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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|
Pathways & Interactions
for OBP2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OBP2B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for OBP2B (Q9NPH63 ENSP000003611044) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
OBP2B for ontologies About GeneDecksing
|
Drugs & Compounds
for OBP2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OBP2B
Search CenterWatch for drugs/clinical trials and news about OBP2B
|
Transcripts
for OBP2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OBP2B gene: NM_014581.2 Unigene Cluster for OBP2B: Odorant binding protein 2B Hs.449629 [show with all ESTs]Unigene Representative Sequence: BC0983404 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372034(uc004ccz.3) ENST00000473737(uc010nad.3) ENST00000461961(uc011mcy.2)
ENST00000372032
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OBP2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OBP2B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OBP2B (NM_014581) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OBP2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OBP2B |
Additional cDNA sequence: AJ251026.1 AJ251027.1 AJ251028.1 AY358981.1 BC096717.1 BC098125.1 BC098151.1 BC098340.1 1 DOTS entry: DT.407483 20 AceView cDNA sequences: AY358981 BV204658 BV204655 BV204657 AI143970 AJ251026 BX101545 BV204652 NM_014581 AJ251028 AJ251027 BV204653 AA460323 AA460385 AI251747 BV204654 BV204651 AA977608 BV202087 AW513637
GeneLoc Exon Structure
|
Expression
for OBP2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OBP2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OBP2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OBP2B
SOURCE GeneReport for Unigene cluster: Hs.449629
UniProtKB/Swiss-Prot: OBP2B_HUMAN, Q9NPH6Tissue specificity: Strongly expressed in genital sphere organs such as the prostate and mammary glands
SABiosciences Custom PCR Arrays for OBP2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OBP2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OBP2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OBP2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OBP2B |
Orthologs
for OBP2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OBP2B (if available)
TreeFam Gene Tree for OBP2B (if available) |
Paralogs
for OBP2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OBP2B gene
- OBP2A1 2 LCN12
4 SIMAP similar genes for OBP2B using alignment to 2 protein entries: OBP2B_HUMAN (see all proteins):OBP2C OBP2A LCN1 LCN1P1
OBP2B for paralogs About GeneDecksing
|
Genomic Variants
for OBP2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OBP2B (136080664 - 136084630 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for OBP2B
2 CNVs: 53331 29808 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OBP2B |
|
Disorders
/ Diseases
for OBP2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OBP2B for disorders About GeneDecksing
OMIM gene information: 604606
OMIM disorders: --
3  diseases for OBP2B: About MalaCardsfanconi's anemia anemia prostatitis
Export disorders for OBP2B gene to outside databases
|
Publications
for OBP2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OBP2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with OBP2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres. (PubMed id 10607840)1, 2 Lacazette E.... Pitiot G. (2000)
- TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
- Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties. (PubMed id 12044155)1 Briand L.... Pernollet J.C. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Molecular cloning of odorant-binding protein: member of a ligand carrier family. (PubMed id 3388043)1 Pevsner J....Snyder S.H. (1988)
|
External Searches for OBP2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OBP2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OBP2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OBP2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OBP2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OBP2B gene:
Search GeneIP for patents involving OBP2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OBP2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OBP2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OBP2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OBP2B | | | OriGene Protein Over-expression Lysate for OBP2B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OBP2B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OBP2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OBP2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for OBP2B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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