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OBP2A Gene

protein-coding GIFtS: 46

GC09P137577

odorant binding protein 2A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OBP ^¹, ²
OBP2C ^²
OBPIIa ^², ³
OTTHUMP00000022542 ^²
hOBPIIa ^¹, ²

Descriptions
odorant binding protein 2A ^²
putative odorant-binding protein 2c ^²

External Ids
HGNC: 23380¹
Entrez Gene: 29991²
UniProtKB: Q9NY56³
Ensembl: ENSG00000122136⁷

Search outside databases for aliases for OBP2A gene

Previous GC identifers: GC09P129587 GC09P130209 GC09P131961 GC09P133877 GC09P135663

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OBP2A:

This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein

is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus

to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic

odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of

odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar

family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced

transcript variants have been described, but their biological validity has not been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56

Function: Probably binds and transports small hydrophobic volatile molecules with a higher affinity

for aldehydes and large fatty acids

Gene Wiki entry for OBP2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OBP2A gene

Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34

OBP2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P137577: (about GC identifiers)

Start:	137,577,806 bp from pter
End:	137,581,636 bp from pter
Size:	3,831 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_019501.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56 (See protein sequence)

Recommended Name: Odorant-binding protein 2a precursor

Size: 170 amino acids; 19318 Da

Subunit: Monomer

Subcellular location: Secreted (Probable)

Secondary accessions: Q5T8A3 Q9NY50 Q9NY53 Q9NY54 Q9NY55

Alternative splicing: 4 isoforms: Q9NY56-1 Q9NY56-2 Q9NY56-3 Q9NY56-4

REFSEQ proteins: NP_055397.1

ENSEMBL proteins:

ENSP00000342097 ENSP00000340950 ENSP00000360841

Human Recombinant Proteins

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1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

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Antibodies for OBP2A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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	Search Novus for antibodies for OBP2A

Assays for OBP2A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9NY56

ProtoNet protein and cluster: Q9NY56

2 Blocks protein families:

IPB002345 Lipocalin signature

IPB002450 Von Ebner's gland protein signature

UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56

Similarity: Belongs to the calycin superfamily. Lipocalin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OBP2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OBP2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014582

Applied Biosystems Silencer® siRNAs for OBP2A

Sigma-Aldrich siRNA for OBP2A

Sigma-Aldrich shRNA for OBP2A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OBP2A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014582
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014582
untagged cDNA clone in CMV expression vector: NM_014582

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014582

UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56

Function: Probably binds and transports small hydrophobic volatile molecules with a higher affinity

for aldehydes and large fatty acids

Genatlas biochemistry entry for OBP2A:

odorant binding protein 2A,expressed in the nasal structure,salivary and lacrymal

glands,lung,lipocalin family of outlier group

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0005549	odorant binding	NAS	10607840

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0007608	sensory perception of smell	IEA	--
GO:0050896	response to stimulus	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OBP2A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OBP2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OBP2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014582

Sigma-Aldrich siRNA for OBP2A

Sigma-Aldrich shRNA for OBP2A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014582

REFSEQ mRNAs for OBP2A gene:

NM_014582.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014582

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014582
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014582
                                 untagged cDNA clone in CMV expression vector: NM_014582

Additional cDNA sequence:

AJ251021.1 AJ251022.1 AJ251023.1 AJ251024.1 AM087898.1 BC069563.1 BC143803.1

3 DOTS entries:

DT.121197944 DT.91755850 DT.407483

9 AceView cDNA sequences:

AJ251021 BC069563 NM_014582 AJ251024 AJ251022 AJ251023 AA936288 AI219510

BV202087

highest scoring ESTs for OBP2A:

AA936288 AI219510 AJ251021 AJ251022 AJ251023 AJ251024 BC069563 NM_014582 DT932749 DT932750

Unigene Cluster for OBP2A:

Odorant binding protein 2A

Hs.567489 [show with all ESTs]

Unigene Representative Sequence: AJ251024

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000340780 ENST00000342114 ENST00000371776

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OBP2A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OBP2A

¹ / ² / ³

11 probe-sets matching OBP2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54812_r_at²^{, 3}	U95-C	2	1.00	0.50	1.00	1.00	AA977608	0.40	0.38	0.39	2
234841_x_at²^{, 3}	U133-B	3	1.00	0.62	--	--	AJ251023	0.80	1.00	0.91	1
234436_x_at²^{, 3}	U133-B	2	1.00	0.59	--	--	AJ251022	0.80	1.00	0.91	1
220848_x_at²^{, 3}	U133-A	3	1.00	0.53	--	--	NM_014582	0.60	1.00	0.82	1
233860_s_at²^{, 3}	U133-B	2	1.00	0.50	--	--	AI143970	0.20	0.33	0.27	2
220959_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	NM_014581	0.20	0.33	0.27	2
234841_x_at²	U133Plus2	3	1.00	0.62	--	--	--	--	--	--	--
234436_x_at²	U133Plus2	2	1.00	0.59	--	--	--	--	--	--	--
220848_x_at²	U133Plus2	3	1.00	0.53	--	--	--	--	--	--	--
233860_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
220959_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.567489
UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56
Tissue specificity: Strongly expressed in the nasal structures, salivary and lachrymal glands, and
lung

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OBP2A gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
rat (Rattus norvegicus)	Obp2b¹	--	odorant binding protein 2B	60.08(n) 44.31(a)	286933 NM_173148.1 NP_775171.1
mouse (Mus musculus)	OTTMUSG00000012631¹	--	predicted gene, OTTMUSG00000012631	62.08(n) 47.31(a)	383678 XM_357181.4 XP_357181.4

About this table Species with no ortholog for OBP2A

ENSEMBL Gene Tree for OBP2A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OBP2A gene

LCN1² LCN1L1² OBP2B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/124 NCBI SNPs in OBP2A are shown (see all 124 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 23)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs465208^1,2	A,C,F,H	137577093(+)	`CAGGAG/AGAAAC`	1	--	ng5¹		7	EU EA WA NA	680
	rs547314^1,2	A,C,F,H	137576120(+)	`TCACAA/GCCAAC`	1	--	ng5¹ tfbs³		12	EU EA WA NA	1052
--	rs2853652^1,2	A,C,F,H	137580462(+)	`TTTCAC/TGCCCC`	1	M/T	mis¹ ese³		3	EA WA	296
	rs462537^1,2	A,C,F,H	137576984(+)	`TGTCCT/CGGTGG`	1	--	ng5¹		9	EA EU WA	2274
	rs3762073^1,2	C,F,H	137576044(+)	`TGCGCG/ATGTTG`	1	--	ng5¹		8	EA EU WA NA	2048
--	rs3762078^1,2	C,F,H	137577203(+)	`TGGCCC/TGAGGA`	1	--	ng5¹ tfbs³		4	EU EA WA	418
--	rs3762079^1,2	C,F,H	137577347(+)	`CGTGCG/AGGACT`	1	--	ng5¹		4	EU EA WA	396
	rs3762076^1,2	C,F,H	137577084(+)	`GAACAC/TGTGCA`	1	--	ng5¹ tfbs³		4	EU NA	258
--	rs580072^1,2	C,F,H	137577372(+)	`CCCACA/GTCTCT`	1	--	ng5¹		7	EU EA WA NA	536
--	rs3762081^1,2	C,F,H	137577412(+)	`CAGCAG/AGGAGA`	1	--	ng5¹		4	EU EA WA	408

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HapMap Linkage Disequilibrium images for OBP2A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164320

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/15 PubMed articles for OBP2A gene (see all 15 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties. (PubMed id 12044155)^{3, 4} Briand L....Pernollet J.C. (2002)
A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres. (PubMed id 10607840)^{3, 4} Lacazette E.... Pitiot G. (2000)
Porcine odorant-binding protein selectively binds to a human olfactory receptor. (PubMed id 12379593)^{1, 3} Matarazzo V....Ronin C. (2002)
A single lysyl residue defines the binding specificity of a human odorant-binding protein for aldehydes. (PubMed id 16546182)³ Tcatchoff L....Briand L. (2006)
Comparative ligand-binding analysis of ten human lipocalins. (PubMed id 16461020)³ Breustedt D.A....Skerra A. (2006)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)⁴ Humphray S.J.... Dunham I. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Mammalian odorant binding proteins. (PubMed id 11058764)³ Tegoni M....Cambillau C. (2000)
Odorant-binding proteins in insects. (PubMed id 7613772)¹ Pelosi P. and Maida R. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 29991	HGNC: 23380	AceView: OBP2A	Ensembl:ENSG00000122136	euGenes: HUgn29991
ECgene: OBP2A	H-InvDB: OBP2A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for OBP2A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for OBP2A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OBP2A-related products

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OBP2A Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for OBP2A

Summaries
for OBP2A

Genomic Location
for OBP2A

Proteins
for OBP2A

Protein Domains/
Families
for OBP2A

Gene Function
for OBP2A

Pathways & Interactions
for OBP2A

Drugs & Compounds
for OBP2A

Transcripts
for OBP2A

Expression
for OBP2A

Orthologs
for OBP2A

Paralogs
for OBP2A

SNPs/Variants
for OBP2A

Disorders & Mutations
for OBP2A

Medical News
for OBP2A

Publications
for OBP2A

Search for OBP2A

Genome Databases showing OBP2A

Other Databases showing OBP2A

Specialized Databases showing OBP2A

Licensable Technologies
for OBP2A

Services
for OBP2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OBP2A Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor OBP2A

Summariesfor OBP2A

Genomic Locationfor OBP2A

Proteinsfor OBP2A

Protein Domains/Familiesfor OBP2A

Gene Functionfor OBP2A

Pathways & Interactionsfor OBP2A

Drugs & Compoundsfor OBP2A

Transcriptsfor OBP2A

Expression for OBP2A

Orthologsfor OBP2A

Paralogsfor OBP2A

SNPs/Variantsfor OBP2A

Disorders & Mutationsfor OBP2A

Medical Newsfor OBP2A

Publicationsfor OBP2A

Search for OBP2A

Genome Databases showing OBP2A

Other Databases showing OBP2A

Specialized Databases showing OBP2A

Licensable Technologiesfor OBP2A

Servicesfor OBP2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OBP2A

Summaries
for OBP2A

Genomic Location
for OBP2A

Proteins
for OBP2A

Protein Domains/
Families
for OBP2A

Gene Function
for OBP2A

Pathways & Interactions
for OBP2A

Drugs & Compounds
for OBP2A

Transcripts
for OBP2A

Expression
for OBP2A

Orthologs
for OBP2A

Paralogs
for OBP2A

SNPs/Variants
for OBP2A

Disorders & Mutations
for OBP2A

Medical News
for OBP2A

Publications
for OBP2A

Licensable Technologies
for OBP2A

Services
for OBP2A