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Aliases for OBP2A Gene

Aliases for OBP2A Gene

  • Odorant Binding Protein 2A 2 3
  • Odorant-Binding Protein IIa 3 4
  • OBPIIa 3 4
  • Putative Odorant-Binding Protein 2c 3
  • HOBPIIa 3
  • LCN13 3
  • OBP2C 3
  • OBP 3

External Ids for OBP2A Gene

Previous GeneCards Identifiers for OBP2A Gene

  • GC09P129587
  • GC09P130209
  • GC09P131961
  • GC09P133877
  • GC09P135663
  • GC09P137577
  • GC09P138437
  • GC09P107899

Summaries for OBP2A Gene

Entrez Gene Summary for OBP2A Gene

  • This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for OBP2A Gene

OBP2A (Odorant Binding Protein 2A) is a Protein Coding gene. GO annotations related to this gene include odorant binding. An important paralog of this gene is OBP2B.

UniProtKB/Swiss-Prot for OBP2A Gene

  • Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids.

Gene Wiki entry for OBP2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OBP2A Gene

Genomics for OBP2A Gene

Regulatory Elements for OBP2A Gene

Genomic Location for OBP2A Gene

Chromosome:
9
Start:
135,546,139 bp from pter
End:
135,549,969 bp from pter
Size:
3,831 bases
Orientation:
Plus strand

Genomic View for OBP2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OBP2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OBP2A Gene

Proteins for OBP2A Gene

  • Protein details for OBP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY56-OBP2A_HUMAN
    Recommended name:
    Odorant-binding protein 2a
    Protein Accession:
    Q9NY56
    Secondary Accessions:
    • Q5T8A3
    • Q9NY50
    • Q9NY53
    • Q9NY54
    • Q9NY55

    Protein attributes for OBP2A Gene

    Size:
    170 amino acids
    Molecular mass:
    19318 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for OBP2A Gene

    Alternative splice isoforms for OBP2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OBP2A Gene

Proteomics data for OBP2A Gene at MOPED

Post-translational modifications for OBP2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OBP2A

No data available for DME Specific Peptides for OBP2A Gene

Domains & Families for OBP2A Gene

Gene Families for OBP2A Gene

Suggested Antigen Peptide Sequences for OBP2A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NY56

UniProtKB/Swiss-Prot:

OBP2A_HUMAN :
  • Belongs to the calycin superfamily. Lipocalin family.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with OBP2A: view

Function for OBP2A Gene

Molecular function for OBP2A Gene

GENATLAS Biochemistry:
odorant binding protein 2A,expressed in the nasal structure,salivary and lacrymal glands,lung,lipocalin family of outlier group
UniProtKB/Swiss-Prot Function:
Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids.

Gene Ontology (GO) - Molecular Function for OBP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding NAS 10607840
genes like me logo Genes that share ontologies with OBP2A: view

Phenotypes for OBP2A Gene

GenomeRNAi human phenotypes for OBP2A:
genes like me logo Genes that share phenotypes with OBP2A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OBP2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OBP2A Gene

Localization for OBP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for OBP2A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OBP2A Gene COMPARTMENTS Subcellular localization image for OBP2A gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for OBP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OBP2A: view

Pathways & Interactions for OBP2A Gene

SuperPathways for OBP2A Gene

No Data Available

Interacting Proteins for OBP2A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360841%0d%0a9606.ENSP00000331545%0d%0a
Selected Interacting proteins: ENSP00000360841 Q9NY56-OBP2A_HUMAN for OBP2A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OBP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007606 sensory perception of chemical stimulus TAS 10607840
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OBP2A: view

No data available for Pathways by source and SIGNOR curated interactions for OBP2A Gene

Drugs & Compounds for OBP2A Gene

No Compound Related Data Available

Transcripts for OBP2A Gene

mRNA/cDNA for OBP2A Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OBP2A Gene

Odorant binding protein 2A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OBP2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OBP2A Gene

No ASD Table

Relevant External Links for OBP2A Gene

GeneLoc Exon Structure for
OBP2A
ECgene alternative splicing isoforms for
OBP2A

Expression for OBP2A Gene

mRNA expression in normal human tissues for OBP2A Gene

mRNA differential expression in normal tissues according to GTEx for OBP2A Gene

This gene is overexpressed in Testis (x22.9), Skin - Sun Exposed (Lower leg) (x10.7), and Skin - Not Sun Exposed (Suprapubic) (x7.0).

Protein differential expression in normal tissues from HIPED for OBP2A Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OBP2A Gene



SOURCE GeneReport for Unigene cluster for OBP2A Gene Hs.567489

mRNA Expression by UniProt/SwissProt for OBP2A Gene

Q9NY56-OBP2A_HUMAN
Tissue specificity: Strongly expressed in the nasal structures, salivary and lachrymal glands, and lung
genes like me logo Genes that share expression patterns with OBP2A: view

Protein tissue co-expression partners for OBP2A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for OBP2A Gene

Orthologs for OBP2A Gene

This gene was present in the common ancestor of mammals.

Orthologs for OBP2A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Obp2b 35
  • 62.08 (n)
  • 47.31 (a)
Lcn4 36
  • 34 (a)
ManyToMany
Obp2b 36
  • 44 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Obp2b 35
  • 60.08 (n)
  • 44.31 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 54 (a)
OneToMany
Species with no ortholog for OBP2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OBP2A Gene

ENSEMBL:
Gene Tree for OBP2A (if available)
TreeFam:
Gene Tree for OBP2A (if available)

Paralogs for OBP2A Gene

Paralogs for OBP2A Gene

(4) SIMAP similar genes for OBP2A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OBP2A: view

Variants for OBP2A Gene

Sequence variations from dbSNP and Humsavar for OBP2A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs552189024 -- 135,548,901(+) CCCCC(A/G)CATTC intron-variant
rs552167833 -- 135,549,483(+) CCCAC(C/T)CAAAA intron-variant
rs552139333 -- 135,545,481(+) GCCAG(G/T)CTCCG upstream-variant-2KB
rs552038946 -- 135,549,440(+) ACCCC(-/TG)CCCAG intron-variant
rs551789793 -- 135,547,889(+) GCTCA(C/T)ATACC missense, reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for OBP2A Gene

Variant ID Type Subtype PubMed ID
dgv8366n71 CNV Loss 21882294
dgv8367n71 CNV Loss 21882294
nsv466656 CNV Gain 19166990
nsv416052 CNV Insertion 16902084
esv1004958 CNV Insertion 20482838
esv29917 CNV Gain+Loss 19812545
esv1483790 CNV Insertion 17803354

Variation tolerance for OBP2A Gene

Residual Variation Intolerance Score: 96.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.95; 98.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OBP2A Gene

HapMap Linkage Disequilibrium report
OBP2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OBP2A Gene

Disorders for OBP2A Gene

Relevant External Links for OBP2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OBP2A
genes like me logo Genes that share disorders with OBP2A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OBP2A Gene

Publications for OBP2A Gene

  1. Large-scale identification of odorant-binding proteins and chemosensory proteins from expressed sequence tags in insects. (PMID: 20034407) Xu Y.L. … Li F. (BMC Genomics 2009) 23 67
  2. Genome analysis and expression patterns of odorant-binding proteins from the Southern House mosquito Culex pipiens quinquefasciatus. (PMID: 19606229) Pelletier J. … Leal W.S. (PLoS ONE 2009) 23 67
  3. Structure of an odorant-binding protein from the mosquito Aedes aegypti suggests a binding pocket covered by a pH-sensitive "Lid". (PMID: 19956631) Leite N.R. … Oliva G. (PLoS ONE 2009) 23 67
  4. Identification of odorant-binding proteins of the yellow fever mosquito Aedes aegypti: genome annotation and comparative analyses. (PMID: 18353104) Zhou J.J. … Field L.M. (Insect Mol. Biol. 2008) 23 67
  5. Temperature-induced molten globule-like state in human alpha1-acid glycoprotein: an infrared spectroscopic study. (PMID: 16331959) Ausili A. … Tanfani F. (Biochemistry 2005) 23 67

Products for OBP2A Gene

Sources for OBP2A Gene

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