OBP2A Gene
protein-coding GIFtS: 46
GCID: GC09P138437
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odorant binding protein 2A
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Aliases
for OBP2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Odorant Binding Protein 2A1 2 | | OBPIIa2 3 | | OBP1 2 | | OBP2C2 | | HOBPIIa1 | | Odorant-Binding Protein 2a2 | | Odorant-Binding Protein IIa2 3 | | Putative Odorant-Binding Protein 2c2 |
Export aliases for OBP2A gene to outside databasesPrevious GC identifers: GC09P129587 GC09P130209 GC09P131961 GC09P133877 GC09P135663 GC09P137577 GC09P107899 |
Summaries
for OBP2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OBP2A:
This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought totransport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and mayalso function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasalmucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and ahighly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively splicedtranscript variants have been described, but their biological validity has not been determined. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56Function: Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes andlarge fatty acids
Gene Wiki entry for OBP2A
|
Genomic Views
for OBP2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_019501.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OBP2A gene promoter:
Max1 COUP-TF1 PPAR-gamma1 COUP PPAR-gamma2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for OBP2A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OBP2A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34OBP2A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P138437: view genomic region
(about GC identifiers)
Start:
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138,437,985 bp from pter |
End:
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138,441,815 bp from pter |
Size:
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3,831 bases |
Orientation:
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plus strand |
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Proteins
for OBP2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56 (See
protein sequence)Recommended Name: Odorant-binding protein 2a precursor Size: 170 amino acids; 19318 Da
Subunit: Monomer
Subcellular location: Secreted (Probable)
Secondary accessions: Q5T8A3 Q9NY50 Q9NY53 Q9NY54 Q9NY55Alternative splicing: 4 isoforms: Q9NY56-1 Q9NY56-2 Q9NY56-3 Q9NY56-4 Explore the universe of human proteins at neXtProt for OBP2A: NX_Q9NY56
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NY56
OBP2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055397.1
ENSEMBL proteins: ENSP00000443986 ENSP00000342097 ENSP00000436685 ENSP00000340950 ENSP00000360841 ENSP00000441028
Human Recombinant Protein Products for OBP2A:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005576 | extracellular region |
IEA | -- |
OBP2A for ontologies About GeneDecksing
OBP2A Antibody Products:
Assay Products for OBP2A: |
Protein
Domains /
Families
for OBP2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OBP2A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NY56ProtoNet protein and cluster: Q9NY56 2 Blocks protein families: IPB002345 Lipocalin signature IPB002450 Von Ebner's gland protein signature
UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56Similarity: Belongs to the calycin superfamily. Lipocalin family |
Function
for OBP2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: OBP2A_HUMAN, Q9NY56Function: Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes andlarge fatty acids Genatlas biochemistry entry for OBP2A:odorant binding protein 2A,expressed in the nasal structure,salivary and lacrymal glands,lung,lipocalin family ofoutlier group
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
OBP2A for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OBP2A
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|
Pathways & Interactions
for OBP2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OBP2A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for OBP2A (Q9NY563 ENSP000003608414) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
OBP2A for ontologies About GeneDecksing
|
Drugs & Compounds
for OBP2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OBP2A
Search CenterWatch for drugs/clinical trials and news about OBP2A
|
Transcripts
for OBP2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OBP2A gene: NM_014582.2 Unigene Cluster for OBP2A: Odorant binding protein 2A Hs.567489 [show with all ESTs]Unigene Representative Sequence: AJ2510246 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000537747 ENST00000340780(uc004cgc.3) ENST00000471886(uc010nau.3)
ENST00000342114(uc010nav.3) ENST00000371776(uc004cgb.3) ENST00000539850
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OBP2A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OBP2A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OBP2A (NM_014582) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OBP2A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OBP2A |
Additional cDNA sequence: AJ251021.1 AJ251022.1 AJ251023.1 AJ251024.1 AM087898.1 BC069563.1 BC143803.1 3 DOTS entries: DT.121197944 DT.91755850 DT.407483 9 AceView cDNA sequences: AJ251021 BC069563 NM_014582 AJ251024 AJ251022 AJ251023 AI219510 AA936288 BV202087
GeneLoc Exon Structure
|
Expression
for OBP2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OBP2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OBP2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OBP2A
SOURCE GeneReport for Unigene cluster: Hs.567489
UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56Tissue specificity: Strongly expressed in the nasal structures, salivary and lachrymal glands, and lung
SABiosciences Custom PCR Arrays for OBP2A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OBP2A
Browse OriGene validated miRNA SYBR primer pairs
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Orthologs
for OBP2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OBP2A (if available)
TreeFam Gene Tree for OBP2A (if available) |
Paralogs
for OBP2A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OBP2A gene
- OBP2B1 2 LCN12
4 SIMAP similar genes for OBP2A using alignment to 5 protein entries: OBP2A_HUMAN (see all proteins):OBP2C OBP2B LCN1P1 LCN1
OBP2A for paralogs About GeneDecksing
|
Genomic Variants
for OBP2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OBP2A (138437985 - 138441815 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OBP2A
1 Indel: 70828 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OBP2A |
|
Disorders
/ Diseases
for OBP2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OBP2A for disorders About GeneDecksing
OMIM gene information: 164320
OMIM disorders: --
3  diseases for OBP2A: About MalaCardsyellow fever chickenpox malaria
Export disorders for OBP2A gene to outside databases
|
Publications
for OBP2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OBP2A gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with OBP2A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties. (PubMed id 12044155)1, 2 Briand L.... Pernollet J.C. (2002)
- A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres. (PubMed id 10607840)1, 2 Lacazette E.... Pitiot G. (2000)
- Porcine odorant-binding protein selectively binds to a human olfactory receptor. (PubMed id 12379593)1, 9 Matarazzo V....Ronin C. (2002)
- A single lysyl residue defines the binding specificity of a human odorant-binding protein for aldehydes. (PubMed id 16546182)1 Tcatchoff L....Briand L. (2006)
- Comparative ligand-binding analysis of ten human lipocalins. (PubMed id 16461020)1 Breustedt D.A....Skerra A. (2006)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Mammalian odorant binding proteins. (PubMed id 11058764)1 Tegoni M....Cambillau C. (2000)
- Genome analysis and expression patterns of odorant-bi nding proteins from the Southern House mosquito Culex pipiens quinquefasciatus. (PubMed id 19606229)9 Pelletier J. and Leal W.S. (2009)
|
External Searches for OBP2A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OBP2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OBP2A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OBP2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OBP2A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OBP2A gene:
Search GeneIP for patents involving OBP2A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OBP2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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