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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OBP2A Gene

protein-coding   GIFtS: 47
GCID: GC09P138437

Odorant Binding Protein 2A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Odorant Binding Protein 2A1 2     OBP2C2
Odorant-Binding Protein IIa2 3     hOBPIIa2
OBPIIa2 3     Odorant-Binding Protein 2a2
OBP2     Putative Odorant-Binding Protein 2c2

External Ids:    HGNC: 233801   Entrez Gene: 299912   Ensembl: ENSG000001221367   OMIM: 1643205   UniProtKB: Q9NY563   

Export aliases for OBP2A gene to outside databases

Previous GC identifers: GC09P129587 GC09P130209 GC09P131961 GC09P133877 GC09P135663 GC09P137577 GC09P107899


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OBP2A Gene:
This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to
transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and
may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in
the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids.
This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9.
Alternatively spliced transcript variants have been described, but their biological validity has not been
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for OBP2A Gene: 
OBP2A (odorant binding protein 2A) is a protein-coding gene. Diseases associated with OBP2A include yellow fever, and chickenpox. GO annotations related to this gene include odorant binding. An important paralog of this gene is LCN1.

UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56
Function: Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes
and large fatty acids

Gene Wiki entry for OBP2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_019501.13  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OBP2A gene promoter:
         Max1   COUP-TF1   PPAR-gamma1   COUP   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOBP2A promoter sequence
   Search SABiosciences Chromatin IP Primers for OBP2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OBP2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34

OBP2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OBP2A gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P138437:  view genomic region     (about GC identifiers)

Start:
138,437,985 bp from pter      End:
138,441,815 bp from pter
Size:
3,831 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56 (See protein sequence)
Recommended Name: Odorant-binding protein 2a precursor  
Size: 170 amino acids; 19318 Da
Subunit: Monomer
Subcellular location: Secreted (Probable)
Secondary accessions: Q5T8A3 Q9NY50 Q9NY53 Q9NY54 Q9NY55
Alternative splicing: 4 isoforms:  Q9NY56-1   Q9NY56-2   Q9NY56-3   Q9NY56-4   

Explore the universe of human proteins at neXtProt for OBP2A: NX_Q9NY56

Explore proteomics data for OBP2A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NY56

  • OBP2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OBP2A Protein Expression
    REFSEQ proteins: NP_055397.1  
    ENSEMBL proteins: 
     ENSP00000443986   ENSP00000342097   ENSP00000436685   ENSP00000340950   ENSP00000360841  
     ENSP00000441028  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    OBP2A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LCN: Lipocalins

    4 InterPro protein domains:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR002450 von_Ebner_gland
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9NY56

    ProtoNet protein and cluster: Q9NY56

    2 Blocks protein domains:
    IPB002345 Lipocalin signature
    IPB002450 Von Ebner's gland protein signature


    UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56
    Similarity: Belongs to the calycin superfamily. Lipocalin family


    OBP2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OBP2A_HUMAN, Q9NY56
    Function: Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes
    and large fatty acids

         Genatlas biochemistry entry for OBP2A:
    odorant binding protein 2A,expressed in the nasal structure,salivary and lacrymal glands,lung,lipocalin family of
    outlier group

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005549odorant binding NAS10607840
         
    OBP2A for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OBP2A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for OBP2A (Q9NY563 ENSP000003608414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR1G1P478903, ENSP000003315454I2D: score=1 STRING: ENSP00000331545
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0007606sensory perception of chemical stimulus TAS10607840
    GO:0007608sensory perception of smell IEA--
    GO:0050896response to stimulus IEA--

    OBP2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OBP2A

    Search CenterWatch for drugs/clinical trials and news about OBP2A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OBP2A gene: 
    NM_014582.2  

    Unigene Cluster for OBP2A:

    Odorant binding protein 2A
    Hs.567489  [show with all ESTs]
    Unigene Representative Sequence: AJ251024
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537747 ENST00000340780(uc004cgc.3) ENST00000471886(uc010nau.3)
    ENST00000342114(uc010nav.3) ENST00000371776(uc004cgb.3) ENST00000539850

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    Additional mRNA sequence: 

    AJ251021.1 AJ251022.1 AJ251023.1 AJ251024.1 AM087898.1 BC069563.1 BC143803.1 

    3 DOTS entries:

    DT.121197944  DT.91755850  DT.407483 

    9 AceView cDNA sequences:

    NM_014582 BC069563 AJ251021 AJ251023 AJ251024 AJ251022 AA936288 AI219510 
    BV202087 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OBP2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OBP2A Expression
    About this image


    See OBP2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OBP2A

    SOURCE GeneReport for Unigene cluster: Hs.567489

    UniProtKB/Swiss-Prot: OBP2A_HUMAN, Q9NY56
    Tissue specificity: Strongly expressed in the nasal structures, salivary and lachrymal glands, and lung

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for OBP2A gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Obp2b1 odorant binding protein 2B 62.08(n)
    47.31(a)
      383678  NM_001099301.1  NP_001092771.1 


    ENSEMBL Gene Tree for OBP2A (if available)
    TreeFam Gene Tree for OBP2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OBP2A gene
    OBP2B1 2  LCN12  
    4 SIMAP similar genes for OBP2A using alignment to 5 protein entries:     OBP2A_HUMAN (see all proteins):
    OBP2C    OBP2B    LCN1P1    LCN1

    OBP2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/287 SNPs in OBP2A are shown (see all 287)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112864161,2
    C,F--138436450(+) AAAAAA/-TTAGC 1 -- us2k12Minor allele frequency- -:0.50NA 4
    rs38347491,2
    C--138437195(+) AGAGAG/-GGGGA 1 -- us2k1 trp31Minor allele frequency- -:0.00CSA 2
    rs48418781,2
    C,A--138440823(+) CGATGA/C/GGGTCT 1 -- int10--------
    rs1863343651,2
    --138471018(+) CTGGGA/GGCCAG 1 -- us2k10--------
    rs754104171,2
    F--138471150(+) CTGGGA/GCACAG 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1895266561,2
    --138471196(+) GCACCC/TGTACC 1 -- us2k10--------
    rs1820304031,2
    --138471234(+) CTGTTC/TCCTGA 1 -- us2k10--------
    rs37620731,2
    C,F,H--138471251(+) TGCGCG/ATGTTG 1 -- us2k125Minor allele frequency- A:0.17EA NS NA WA CSA 3866
    rs1175121761,2
    C,F--138471304(+) CATACG/AGTGCT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1860048661,2
    --138471317(+) AATCAA/GTGATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OBP2A (138437985 - 138441815 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for OBP2A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1483790CNV Insertion17803354
    esv1004958CNV Insertion20482838
    nsv416052CNV Insertion16902084
    dgv8367n71CNV Loss21882294
    dgv8366n71CNV Loss21882294
    nsv466656CNV Gain19166990
    esv29917CNV Gain+Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164320    OMIM disorders: --

    3 diseases for OBP2A:    About MalaCards
    yellow fever    chickenpox    malaria


    OBP2A for disorders           About GeneDecksing


    Export disorders for OBP2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OBP2A gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with OBP2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties. (PubMed id 12044155)1, 2 Briand L.... Pernollet J.C. (2002)
    3. A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres. (PubMed id 10607840)1, 2 Lacazette E.... Pitiot G. (2000)
    4. Porcine odorant-binding protein selectively binds to a human olfactory receptor. (PubMed id 12379593)1, 9 Matarazzo V....Ronin C. (2002)
    5. Linkage analysis identifies a locus for plasma von Wil lebrand factor undetected by genome-wide association. (PubMed id 23267103)1 Desch K.C....Ginsburg D. (2013)
    6. A single lysyl residue defines the binding specificity of a human odorant-binding protein for aldehydes. (PubMed id 16546182)1 Tcatchoff L....Briand L. (2006)
    7. Comparative ligand-binding analysis of ten human lipocalins. (PubMed id 16461020)1 Breustedt D.A....Skerra A. (2006)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Mammalian odorant binding proteins. (PubMed id 11058764)1 Tegoni M....Cambillau C. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29991 HGNC: 23380 AceView: OBP2A Ensembl:ENSG00000122136 euGenes: HUgn29991
    ECgene: OBP2A H-InvDB: OBP2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OBP2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OBP2A gene:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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