OBFC1 Gene
protein-coding GIFtS: 48
GCID: GC10M105632
|
|
oligonucleotide/oligosaccharide-binding fold containing...
| |
Aliases
for OBFC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oligonucleotide/Oligosaccharide-Binding Fold Containing 11 2 | | AAF-442 | | STN12 3 5 | | RP11-541N10.22 | | BA541N10.21 | | RPA-322 | | Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 12 3 | | Alpha Accessory Factor 442 | | Suppressor Of Cdc Thirteen Homolog2 3 | | CST Complex Subunit STN12 | | AAF442 5 | | Replication Protein A 32 KDa Subunit2 | | FLJ225591 | | |
Export aliases for OBFC1 gene to outside databasesPrevious GC identifers: GC10M105307 GC10M099268 |
Summaries
for OBFC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OBFC1:
OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNApolymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 (PubMed19119139)). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM613130) (Miyake et al., 2009 (PubMed 19854130)).(supplied by OMIM, Nov 2009)
UniProtKB/Swiss-Prot: STN1_HUMAN, Q9H668Function: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protecttelomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independentmanner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CSTcomplex has probably a more general role in DNA metabolism at non-telomeric sites
|
Genomic Views
for OBFC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OBFC1 gene promoter:
HOXA9B HOXA9 LHX3b/Lhx3b Tal-1 Meis-1b E47 LHX3a/Lhx3a Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OBFC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OBFC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.33 Ensembl cytogenetic band: 10q24.33 HGNC cytogenetic band: 10q25.1OBFC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M105632: view genomic region
(about GC identifiers)
Start:
|
105,637,316 bp from pter |
End:
|
105,678,045 bp from pter |
Size:
|
40,730 bases |
Orientation:
|
minus strand |
|
Proteins
for OBFC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STN1_HUMAN, Q9H668 (See
protein sequence)Recommended Name: CST complex subunit STN1 Size: 368 amino acids; 42119 Da
Subunit: Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1/OBFC1. Interacts withTEN1/C17orf106 and CTC1/C17orf68; the interaction is direct. Interacts with ACD/TPP1
Subcellular location: Nucleus. Chromosome, telomere
Secondary accessions: D3DR99 Q5TCZ0Explore the universe of human proteins at neXtProt for OBFC1: NX_Q9H668
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H668
OBFC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079204.2
ENSEMBL proteins: ENSP00000224950 ENSP00000358779
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
OBFC1 for ontologies About GeneDecksing
OBFC1 Antibody Products:
Assay Products for OBFC1: |
Protein
Domains /
Families
for OBFC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OBFC1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H668ProtoNet protein and cluster: Q9H668 1 Blocks protein family: IPB004365 OB-fold nucleic acid binding domain
UniProtKB/Swiss-Prot: STN1_HUMAN, Q9H668Similarity: Belongs to the STN1 familySimilarity: Contains 1 OB DNA-binding domain |
Function
for OBFC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STN1_HUMAN, Q9H668Function: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protecttelomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independentmanner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CSTcomplex has probably a more general role in DNA metabolism at non-telomeric sites
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OBFC1
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OBFC1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
OBFC1 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for OBFC1:
|
Pathways & Interactions
for OBFC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OBFC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/24 Interacting proteins for OBFC1 (Q9H6682, 3 ENSP000002249504) via UniProtKB, MINT, STRING, and/or I2D (see all 24)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
OBFC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for OBFC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OBFC1
Search CenterWatch for drugs/clinical trials and news about OBFC1 / STN1
|
Transcripts
for OBFC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OBFC1 gene: NM_024928.4 Unigene Cluster for OBFC1: Oligonucleotide/oligosaccharide-binding fold containing 1 Hs.62314 [show with all ESTs]Unigene Representative Sequence: NM_0249284 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000224950(uc001kxm.3) ENST00000369764(uc001kxl.3) ENST00000466828
ENST00000472951
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OBFC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Synthesis Service for OBFC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OBFC1 |
Additional cDNA sequence: AK026212.1 AK057720.1 BC017400.2 9 DOTS entries: DT.120029 DT.109159 DT.97844036 DT.91761464 DT.100025308 DT.100779229 DT.121283684 DT.95164581 DT.95164583 24/124 AceView cDNA sequences (see all 124): AI332546 BQ001796 BQ012922 CA842906 BM916320 AI288528 BM968640 CR600104 CR609551 AI078563 W73832 BM454693 AA295283 BF969177 CR607240 AA505561 CR617185 CA311279 BM675406 AI371170 BI819194 BU683198 BX952701 BG330913
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for OBFC1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|
|
| SP1: | | | | | - | | | | | | - | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for OBFC1
|
Expression
for OBFC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OBFC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTCTGCTG
About this image
See OBFC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OBFC1
SOURCE GeneReport for Unigene cluster: Hs.62314
SABiosciences Expression via Pathway-Focused PCR Array including OBFC1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OBFC1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OBFC1 |
Orthologs
for OBFC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OBFC1 gene from 5/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Obfc11 , 5 |
oligonucleotide/oligosaccharide-binding fold containing 1 less1, 5 |
77.72(n)1
70.92(a)1 |
|
19 (39.64 cM)5
1086891 NM_175360.21 NP_780569.11
475010485 |
chicken
(Gallus gallus) |
Aves |
OBFC11 |
oligonucleotide/oligosaccharide-binding fold containing 1 less |
62.22(n)
58.61(a) |
|
423877 XM_421742.3 XP_421742.2 |
lizard
(Anolis carolinensis) |
Reptilia |
OBFC16 |
-- |
49(a) |
1 ↔ 1 |
3(41310977-41338591) |
African clawed frog
(Xenopus laevis) |
Amphibia |
480200632 |
-- |
68.78(n) |
|
48020063 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc641742 |
hypothetical protein MGC64174 |
76.59(n) |
|
393360 BC053298.1 |
ENSEMBL Gene Tree for OBFC1 (if available)
TreeFam Gene Tree for OBFC1 (if available) |
Paralogs
for OBFC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OBFC1 gene
OBFC1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for OBFC1
PGOHUM00000238836 PGOHUM00000235818
|
Genomic Variants
for OBFC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OBFC1 (105637316 - 105678045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OBFC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OBFC1 |
|
Disorders
/ Diseases
for OBFC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OBFC1 for disorders About GeneDecksing
OMIM gene information: 613128
OMIM disorders: --
4  diseases for OBFC1: About MalaCardsdyskeratosis congenita uterine fibroid dyskeratosis alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: OBFC1 (3 documents)
Export disorders for OBFC1 gene to outside databases
|
Publications
for OBFC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OBFC1 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with OBFC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. (PubMed id 19648609)1, 2, 9 Wan M.... Liu D. (2009)
- RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to si ngle-stranded DNA and protects telomeres independently of the Pot1 pathway. (PubMed id 19854130)1, 2 Miyake Y....Ishikawa F. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- The human CST complex is a terminator of telomerase ac tivity. (PubMed id 22763445)1 Chen L.Y....Lingner J. (2012)
- Human CST promotes telomere duplex replication and gen eral replication restart after fork stalling. (PubMed id 22863775)1 Stewart J.A....Price C.M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for OBFC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OBFC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OBFC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OBFC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OBFC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OBFC1 gene:
Search GeneIP for patents involving OBFC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OBFC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OBFC1 |
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