Aliases for OBFC1 Gene
External Ids for OBFC1 Gene
Previous GeneCards Identifiers for OBFC1 Gene
OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]
GeneCards Summary for OBFC1 Gene
OBFC1 (Oligonucleotide/Oligosaccharide-Binding Fold Containing 1) is a Protein Coding gene. Diseases associated with OBFC1 include pulmonary fibrosis, idiopathic. GO annotations related to this gene include single-stranded DNA binding and single-stranded telomeric DNA binding.
UniProtKB/Swiss-Prot for OBFC1 Gene
Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.