Aliases for OBFC1 Gene
External Ids for OBFC1 Gene
OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]
GeneCards Summary for OBFC1 Gene
OBFC1 (Oligonucleotide/Oligosaccharide-Binding Fold Containing 1) is a Protein Coding gene. Diseases associated with OBFC1 include pulmonary fibrosis, idiopathic. GO annotations related to this gene include single-stranded DNA binding and single-stranded telomeric DNA binding.
UniProtKB/Swiss-Prot for OBFC1 Gene
Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.