Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OAZ3 Gene

Aliases for OAZ3 Gene

  • Ornithine Decarboxylase Antizyme 3 2 3 5
  • ODC-Az 3 3 4
  • AZ3 3 4
  • Testicular Secretory Protein Li 31 3
  • Antizyme 3 3
  • TISP15 3
  • OAZ-T 3

External Ids for OAZ3 Gene

Previous GeneCards Identifiers for OAZ3 Gene

  • GC01P149579
  • GC01P147521
  • GC01P148514
  • GC01P148955
  • GC01P148552
  • GC01P150002
  • GC01P151735
  • GC01P123112

Summaries for OAZ3 Gene

Entrez Gene Summary for OAZ3 Gene

  • The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for OAZ3 Gene

OAZ3 (Ornithine Decarboxylase Antizyme 3) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity and ornithine decarboxylase inhibitor activity. An important paralog of this gene is OAZ1.

UniProtKB/Swiss-Prot for OAZ3 Gene

  • Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity).

Additional gene information for OAZ3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAZ3 Gene

Genomics for OAZ3 Gene

GeneHancer (GH) Regulatory Elements for OAZ3 Gene

Promoters and enhancers for OAZ3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I151762 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556.1 +0.6 552 2.4 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B OAZ3 MRPL9 SETDB1 ZNF687 PI4KB UBE2D3P3 SNX27 CTSK ENSG00000249602 RIIAD1
GH01I151790 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.8 +27.9 27902 2 HDGF PKNOX1 SMAD1 ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B YY1 SLC30A9 TDRKH-AS1 TDRKH PIP5K1A SETDB1 MRPL9 ARNT GABPB2 PI4KB UBE2D3P3 C1orf56
GH01I151610 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 -150.8 -150800 3.5 HDGF PKNOX1 SMAD1 FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 SNX27 ENSG00000250734 SETDB1 PIP5K1A ZNF687 CTSK PI4KB C1orf56 UBE2D3P3 GOLPH3L
GH01I151537 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 -222.7 -222693 7.3 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B YY1 TUFT1 ENSG00000232536 POGZ CGN LYSMD1 SNX27 HRNR CELF3 ENSG00000227045 RIIAD1
GH01I151720 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.6 -41.9 -41880 1.2 CTCF PKNOX1 MXI1 SUZ12 TAL1 MAX SIN3A BMI1 GLIS2 POLR2A RIIAD1 ENSG00000232937 OAZ3 MRPL9 SNX27 ENSG00000250734 CGN ENSG00000252840 LOC100132111 ENSG00000201134
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OAZ3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OAZ3 gene promoter:

Genomic Locations for OAZ3 Gene

Genomic Locations for OAZ3 Gene
chr1:151,762,899-151,771,334
(GRCh38/hg38)
Size:
8,436 bases
Orientation:
Plus strand
chr1:151,735,445-151,743,808
(GRCh37/hg19)

Genomic View for OAZ3 Gene

Genes around OAZ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OAZ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OAZ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAZ3 Gene

Proteins for OAZ3 Gene

  • Protein details for OAZ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMX2-OAZ3_HUMAN
    Recommended name:
    Ornithine decarboxylase antizyme 3
    Protein Accession:
    Q9UMX2
    Secondary Accessions:
    • E7EUE7
    • Q6GMR0

    Protein attributes for OAZ3 Gene

    Size:
    235 amino acids
    Molecular mass:
    27413 Da
    Quaternary structure:
    • Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:17900240). Interacts with GGN (By similarity).
    SequenceCaution:
    • Sequence=AAD51734.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD51734.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Alternative splice isoforms for OAZ3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OAZ3 Gene

Post-translational modifications for OAZ3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for OAZ3 Gene

Domains & Families for OAZ3 Gene

Gene Families for OAZ3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OAZ3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UMX2

UniProtKB/Swiss-Prot:

OAZ3_HUMAN :
  • Belongs to the ODC antizyme family.
Family:
  • Belongs to the ODC antizyme family.
genes like me logo Genes that share domains with OAZ3: view

Function for OAZ3 Gene

Molecular function for OAZ3 Gene

UniProtKB/Swiss-Prot Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity).

Phenotypes From GWAS Catalog for OAZ3 Gene

Gene Ontology (GO) - Molecular Function for OAZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17900240
GO:0008073 ornithine decarboxylase inhibitor activity ISS,TAS --
GO:0015489 putrescine transmembrane transporter activity ISS --
genes like me logo Genes that share ontologies with OAZ3: view
genes like me logo Genes that share phenotypes with OAZ3: view

Animal Models for OAZ3 Gene

MGI Knock Outs for OAZ3:

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OAZ3 Gene

Localization for OAZ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OAZ3 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OAZ3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OAZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,HDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0072562 blood microparticle HDA,IDA 22516433
genes like me logo Genes that share ontologies with OAZ3: view

Pathways & Interactions for OAZ3 Gene

genes like me logo Genes that share pathways with OAZ3: view

Gene Ontology (GO) - Biological Process for OAZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006595 polyamine metabolic process IBA --
GO:0006596 polyamine biosynthetic process IEA --
GO:0007283 spermatogenesis TAS,IEA --
GO:0015847 putrescine transport IEA --
genes like me logo Genes that share ontologies with OAZ3: view

No data available for SIGNOR curated interactions for OAZ3 Gene

Drugs & Compounds for OAZ3 Gene

(1) Drugs for OAZ3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ornithine Approved Nutra Target 70
genes like me logo Genes that share compounds with OAZ3: view

Transcripts for OAZ3 Gene

Unigene Clusters for OAZ3 Gene

Ornithine decarboxylase antizyme 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OAZ3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: - -
SP2: -
SP3:

Relevant External Links for OAZ3 Gene

GeneLoc Exon Structure for
OAZ3
ECgene alternative splicing isoforms for
OAZ3

Expression for OAZ3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OAZ3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OAZ3 Gene

This gene is overexpressed in Testis (x33.4).

NURSA nuclear receptor signaling pathways regulating expression of OAZ3 Gene:

OAZ3

SOURCE GeneReport for Unigene cluster for OAZ3 Gene:

Hs.713789

mRNA Expression by UniProt/SwissProt for OAZ3 Gene:

Q9UMX2-OAZ3_HUMAN
Tissue specificity: Testis specific.

Evidence on tissue expression from TISSUES for OAZ3 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with OAZ3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OAZ3 Gene

Orthologs for OAZ3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OAZ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OAZ3 33 34
  • 99.01 (n)
dog
(Canis familiaris)
Mammalia OAZ3 33 34
  • 91.31 (n)
cow
(Bos Taurus)
Mammalia OAZ3 33 34
  • 89.08 (n)
mouse
(Mus musculus)
Mammalia Oaz3 33 16 34
  • 88.65 (n)
rat
(Rattus norvegicus)
Mammalia Oaz3 33
  • 87.43 (n)
oppossum
(Monodelphis domestica)
Mammalia OAZ3 34
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OAZ3 34
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii oaz2b 34
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Oda 34
  • 16 (a)
OneToMany
Species where no ortholog for OAZ3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OAZ3 Gene

ENSEMBL:
Gene Tree for OAZ3 (if available)
TreeFam:
Gene Tree for OAZ3 (if available)

Paralogs for OAZ3 Gene

Paralogs for OAZ3 Gene

(2) SIMAP similar genes for OAZ3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with OAZ3: view

Variants for OAZ3 Gene

Sequence variations from dbSNP and Humsavar for OAZ3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000077895 -- 151,771,494(+) T/C downstream_transcript_variant
rs1000681460 -- 151,761,067(+) T/C upstream_transcript_variant
rs1001105807 -- 151,765,278(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001130916 -- 151,764,478(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1001159552 -- 151,764,943(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Variation tolerance for OAZ3 Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OAZ3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OAZ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OAZ3 Gene

Disorders for OAZ3 Gene

Additional Disease Information for OAZ3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OAZ3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OAZ3 Gene

Publications for OAZ3 Gene

  1. Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3. (PMID: 16542438) Christensen GL … Carrell DT (BMC medical genetics 2006) 3 22 44 58
  2. Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3. (PMID: 10781085) Ivanov IP … Atkins JF (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4 58
  3. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. (PMID: 17900240) Kanerva K … Andersson LC (The Biochemical journal 2008) 3 4 58
  4. ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1. (PMID: 18062773) Snapir Z … Kahana C (The Biochemical journal 2008) 3 22 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for OAZ3 Gene

Sources for OAZ3 Gene

Content
Loading form....