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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OAZ3 Gene

protein-coding   GIFtS: 52
GCID: GC01P151735

ornithine decarboxylase antizyme 3

 Explore 2 diseases affiliated with
OAZ3 via our new
 Human Malady Compendium 
Biological research products
for OAZ3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ornithine Decarboxylase Antizyme 31 2
AZ32 3
ODC-Az 32 3
OAZ-T1
TISP152
Antizyme 32

External Ids:    HGNC: 80971   Entrez Gene: 516862   Ensembl: ENSG000001434507   OMIM: 6051385   UniProtKB: Q9UMX23   

Export aliases for OAZ3 gene to outside databases

Previous GC identifers: GC01P149579 GC01P147521 GC01P148514 GC01P148955 GC01P148552 GC01P150002 GC01P123112


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OAZ3:
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting
step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine
synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by
polyamine-enhanced translational frameshifting. In contrast to antizymes 1 and 2, which are widely expressed
throughout the body, the expression of this gene product (antizyme 3) is restricted to testis germ cells, and thus it
is a possible candidate for heritable forms of human male infertility. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2008)

UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2
Function: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase
degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of
polyamines in haploid germ cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OAZ3 gene promoter:
         PPAR-gamma1   POU2F1   POU2F1a   FOXO4   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOAZ3 promoter sequence
   Search SABiosciences Chromatin IP Primers for OAZ3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OAZ3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

OAZ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OAZ3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151735:  view genomic region     (about GC identifiers)

Start:
151,735,445 bp from pter      End:
151,743,808 bp from pter
Size:
8,364 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2 (See protein sequence)
Recommended Name: Ornithine decarboxylase antizyme 3  
Size: 187 amino acids; 21375 Da
Subunit: Interacts with GGN (By similarity)
Subcellular location: Nucleus. Cytoplasm (By similarity)
Developmental stage: Expression starts early in spermiogenesis and finishes in the late spermatid phase
Miscellaneous: A ribosomal frameshift occurs between the codons for Ser-28 and Glu-29. An autoregulatory mechanism
enables modulation of frameshifting according to the cellular concentration of polyamines
Ribosomal frameshifting: 1 isoform:  Q9UMX2-1   

Explore the universe of human proteins at neXtProt for OAZ3: NX_Q9UMX2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UMX2

  • OAZ3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128411.1  NP_057262.2  

    ENSEMBL proteins: 
     ENSP00000313922   ENSP00000415904   ENSP00000463055   ENSP00000383784   ENSP00000463692  
     ENSP00000357820  
    Reactome Protein details: Q9UMX2
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OAZ3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--


    OAZ3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OAZ3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002993 ODC_AZ
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q9UMX2

    ProtoNet protein and cluster: Q9UMX2

    1 Blocks protein family: IPB002993 Ornithine decarboxylase antizyme

    UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2
    Similarity: Belongs to the ODC antizyme family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2
    Function: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase
    degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of
    polyamines in haploid germ cells

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    hsa-miR-92a hsa-miR-4325 hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b hsa-miR-384
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008073ornithine decarboxylase inhibitor activity IEA--


    OAZ3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Oaz3tm1Htan for OAZ3
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Oaz3):
     reproductive system 

    OAZ3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    26S proteosome degrades ODC holoenzyme complex0.83
    Regulation of ornithine decarboxylase (ODC)0.80
    2Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives1.00
    3Metabolism
    Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for OAZ3
        26S proteosome degrades ODC holoenzyme complex
    Regulation of ornithine decarboxylase (ODC)
    Metabolism
    Metabolism of amino acids and derivatives



    OAZ3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OAZ3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for OAZ3 (Q9UMX23 ENSP000003139224) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OAZ1P543683, ENSP000003148134I2D: score=1 STRING: ENSP00000314813
    GGNQ86UU53, ENSP000003349404I2D: score=2 STRING: ENSP00000334940
    ODC1P119263, ENSP000002341114I2D: score=1 STRING: ENSP00000234111
    SMAD1Q157973, ENSP000003057694I2D: score=1 STRING: ENSP00000305769
    AZIN1ENSP000003215074STRING: ENSP00000321507
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006521regulation of cellular amino acid metabolic process TAS--
    GO:0007283spermatogenesis TAS10781085
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--


    OAZ3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OAZ3

    1 HMDB Compound for OAZ3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ornithine(+)-S-Ornithine (see all 9)70-26-8--

    1 DrugBank Compound for OAZ3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Ornithine(S)-2,5-Diaminopentanoate (see all 4)70-26-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about OAZ3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OAZ3 gene (2 alternative transcripts): 
    NM_001134939.1  NM_016178.2  

    Unigene Cluster for OAZ3:

    Ornithine decarboxylase antizyme 3
    Hs.713789  [show with all ESTs]
    Unigene Representative Sequence: AK125876
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321531(uc010pdl.2) ENST00000453029 ENST00000479764 ENST00000400999(uc010pdm.2)
    ENST00000577465 ENST00000582415 ENST00000315067

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    hsa-miR-92a hsa-miR-4325 hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b hsa-miR-384
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    Additional cDNA sequence: 

    AF175296.1 AK125876.1 AY713300.1 BC073949.1 BC128558.1 BC128559.1 

    8 DOTS entries:

    DT.95267421  DT.452303  DT.100660559  DT.100660555  DT.100749475  DT.121399295  DT.92440318  DT.95237379 

    24/66 AceView cDNA sequences (see all 66):

    AA838072 AA258740 AA459490 H85177 BE219238 BE042957 BF509459 CB852451 
    BI754531 BP369217 AA682769 AF175296 AA459486 AI215991 BP370114 BP371199 
    BI830988 AI457795 NM_016178 BP369161 AI082170 AA629302 BP371024 AW592562 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for OAZ3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
    SP1:                    -     -                           
    SP2:                    -                                 
    SP3:                                                      


    ECgene alternative splicing isoforms for OAZ3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OAZ3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAATCAGGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See OAZ3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OAZ3

    SOURCE GeneReport for Unigene cluster: Hs.713789

    UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2
    Tissue specificity: Testis specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OAZ3 gene from 1/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    fruit fly
    (Drosophila melanogaster)
    Insecta Oda6
    Ornithine decarboxylase antizyme
    14(a)
    1 → many
    2R(8054077-8061767)


    ENSEMBL Gene Tree for OAZ3 (if available)
    TreeFam Gene Tree for OAZ3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OAZ3 gene
    OAZ22  OAZ12  
    2 SIMAP similar genes for OAZ3 using alignment to 6 protein entries:     OAZ3_HUMAN (see all proteins):
    OAZ2    OAZ1

    OAZ3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/68 NCBI SNPs in OAZ3 are shown (see all 68    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs781243581,2
    --123111114(+) TTGTAC/TGTAAA 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs771682371,2
    C--123111708(-) GGCTGG/TATATG 1 -- us2k10--------
    rs120631191,2
    C,F,--123112084(+) TGCCTT/GTATGT 1 -- us2k12Minor allele frequency- G:0.15CSA WA 122
    rs120280761,2
    H--123112187(+) AAAAAG/TCAAGG 1 -- us2k1 trp34Minor allele frequency- T:0.00NS EA 418
    rs1126854731,2
    --123112924(+) CTTTTT/AGGCAG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs611861681,2
    --123113939(+) GTAGGA/GCATCA 1 -- int12Minor allele frequency- G:0.32CSA WA 120
    rs1132509081,2
    --123113945(+) CATCAG/ATAAGT 2 -- int1 us2k11Minor allele frequency- A:0.50CSA 2
    rs776715781,2
    C,F,--123114197(+) CTCCAA/GTGCTC 2 -- us2k1 int11Minor allele frequency- G:0.07WA 118
    rs1137947121,2
    --123114493(+) TCCTTG/ATTTCT 2 -- int1 us2k11Minor allele frequency- A:0.50CSA 2
    rs1456362151,2
    --151733597(+) GTAGAC/TTCACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for OAZ3 (151735445 - 151743808 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for OAZ3: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OAZ3 for disorders           About GeneDecksing

    OMIM gene information: 605138    OMIM disorders: --

    2 diseases for OAZ3:    About MalaCards
    male infertility    infertility

    Human Genome Epidemiology (HuGE) Navigator: OAZ3 (1 document)

    Export disorders for OAZ3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OAZ3 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with OAZ3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3. (PubMed id 10781085)1, 2, 3 Ivanov I.P....Atkins J.F. (2000)
    2. Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3. (PubMed id 16542438)1, 9 Christensen G.L....Carrell D.T. (2006)
    3. ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1. (PubMed id 18062773)1, 9 Snapir Z....Kahana C. (2008)
    4. Ornithine decarboxylase antizyme Oaz3 modulates prote in phosphatase activity. (PubMed id 21712390)1 Ruan Y....van der Hoorn F.A. (2011)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    7. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    8. Regulation of all members of the antizyme family by antizyme inhibitor. (PubMed id 15355308)1 Mangold U. and Leberer E. (2005)
    9. Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. (PubMed id 15642376)1 Zhang J....Lu B. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51686 HGNC: 8097 AceView: OAZ3 Ensembl:ENSG00000143450 euGenes: HUgn51686
    ECgene: OAZ3 H-InvDB: OAZ3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OAZ3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for OAZ3 gene:
    Search GeneIP for patents involving OAZ3

    GeneCards and IP:
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