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Aliases for OAZ3 Gene

Aliases for OAZ3 Gene

  • Ornithine Decarboxylase Antizyme 3 2 3
  • AZ3 3 4 6
  • ODC-Az 3 3 4
  • Antizyme 3 3
  • TISP15 3
  • OAZ-T 3

External Ids for OAZ3 Gene

Previous GeneCards Identifiers for OAZ3 Gene

  • GC01P149579
  • GC01P147521
  • GC01P148514
  • GC01P148955
  • GC01P148552
  • GC01P150002
  • GC01P151735
  • GC01P123112

Summaries for OAZ3 Gene

Entrez Gene Summary for OAZ3 Gene

  • The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for OAZ3 Gene

OAZ3 (Ornithine Decarboxylase Antizyme 3) is a Protein Coding gene. Diseases associated with OAZ3 include male infertility and infertility. Among its related pathways are Metabolism and Metabolism of amino acids and derivatives. GO annotations related to this gene include ornithine decarboxylase inhibitor activity. An important paralog of this gene is OAZ2.

UniProtKB/Swiss-Prot for OAZ3 Gene

  • Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAZ3 Gene

Genomics for OAZ3 Gene

Regulatory Elements for OAZ3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OAZ3 Gene

Start:
151,762,969 bp from pter
End:
151,771,332 bp from pter
Size:
8,364 bases
Orientation:
Plus strand

Genomic View for OAZ3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OAZ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAZ3 Gene

Proteins for OAZ3 Gene

  • Protein details for OAZ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMX2-OAZ3_HUMAN
    Recommended name:
    Ornithine decarboxylase antizyme 3
    Protein Accession:
    Q9UMX2
    Secondary Accessions:
    • E7EUE7
    • Q6GMR0

    Protein attributes for OAZ3 Gene

    Size:
    235 amino acids
    Molecular mass:
    27413 Da
    Quaternary structure:
    • Interacts with GGN (By similarity). Interacts with AZIN2; the interaction stabilizes the complex by inhibiting AZIN2 ubiquitination and degradation and leads to increased ornithine decarboxylase (ODC) activity and decreased rate of ODC1 degradation.
    SequenceCaution:
    • Sequence=AAD51734.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD51734.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Alternative splice isoforms for OAZ3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OAZ3 Gene

Proteomics data for OAZ3 Gene at MOPED

Post-translational modifications for OAZ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OAZ3 Gene

No data available for DME Specific Peptides for OAZ3 Gene

Domains for OAZ3 Gene

Protein Domains for OAZ3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UMX2

UniProtKB/Swiss-Prot:

OAZ3_HUMAN :
  • Q9UMX2
Family:
  • Belongs to the ODC antizyme family.
genes like me logo Genes that share domains with OAZ3: view

No data available for Gene Families for OAZ3 Gene

Function for OAZ3 Gene

Molecular function for OAZ3 Gene

UniProtKB/Swiss-Prot Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.

Gene Ontology (GO) - Molecular Function for OAZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity --
GO:0005515 protein binding IPI 17900240
GO:0008073 ornithine decarboxylase inhibitor activity ISS --
GO:0015489 putrescine transmembrane transporter activity ISS --
GO:0071532 ankyrin repeat binding IEA --
genes like me logo Genes that share ontologies with OAZ3: view

Phenotypes for OAZ3 Gene

MGI mutant phenotypes for OAZ3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with OAZ3: view

Animal Models for OAZ3 Gene

MGI Knock Outs for OAZ3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OAZ3 Gene

Localization for OAZ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OAZ3 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OAZ3 Gene COMPARTMENTS Subcellular localization image for OAZ3 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OAZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0036126 sperm flagellum IEA --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with OAZ3: view

Pathways for OAZ3 Gene

genes like me logo Genes that share pathways with OAZ3: view

Pathways by source for OAZ3 Gene

Gene Ontology (GO) - Biological Process for OAZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006596 polyamine biosynthetic process IEA --
GO:0007283 spermatogenesis IEA --
GO:0015847 putrescine transport ISS --
GO:0034641 cellular nitrogen compound metabolic process TAS --
genes like me logo Genes that share ontologies with OAZ3: view

Compounds for OAZ3 Gene

(1) HMDB Compounds for OAZ3 Gene

Compound Synonyms Cas Number PubMed IDs
Ornithine
  • (+)-S-Ornithine
70-26-8

(1) Drugbank Compounds for OAZ3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Ornithine
  • (S)-2,5-Diaminopentanoate
70-26-8 target
genes like me logo Genes that share compounds with OAZ3: view

Transcripts for OAZ3 Gene

Unigene Clusters for OAZ3 Gene

Ornithine decarboxylase antizyme 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OAZ3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OAZ3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: - -
SP2: -
SP3:

Relevant External Links for OAZ3 Gene

GeneLoc Exon Structure for
OAZ3
ECgene alternative splicing isoforms for
OAZ3

Expression for OAZ3 Gene

mRNA expression in normal human tissues for OAZ3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OAZ3 Gene

This gene is overexpressed in Testis (33.4).

SOURCE GeneReport for Unigene cluster for OAZ3 Gene Hs.713789

mRNA Expression by UniProt/SwissProt for OAZ3 Gene

Q9UMX2-OAZ3_HUMAN
Tissue specificity: Testis specific
genes like me logo Genes that share expressions with OAZ3: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for OAZ3 Gene

Orthologs for OAZ3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OAZ3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OAZ3 35
  • 89.08 (n)
  • 88.09 (a)
OAZ3 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OAZ3 35
  • 91.31 (n)
  • 90.17 (a)
OAZ3 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oaz3 35
  • 88.65 (n)
  • 89.08 (a)
Oaz3 16
Oaz3 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OAZ3 35
  • 99.01 (n)
  • 99.15 (a)
OAZ3 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oaz3 35
  • 87.43 (n)
  • 85.53 (a)
oppossum
(Monodelphis domestica)
Mammalia OAZ3 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OAZ3 36
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii oaz2b 36
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Oda 36
  • 16 (a)
OneToMany
Species with no ortholog for OAZ3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OAZ3 Gene

ENSEMBL:
Gene Tree for OAZ3 (if available)
TreeFam:
Gene Tree for OAZ3 (if available)

Paralogs for OAZ3 Gene

Paralogs for OAZ3 Gene

Selected SIMAP similar genes for OAZ3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with OAZ3: view

Variants for OAZ3 Gene

Sequence variations from dbSNP and Humsavar for OAZ3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1196457 -- 151,768,003(+) ACCCC(A/C/T)ATCTG intron-variant
rs2495397 -- 151,768,190(-) ATCCA(A/C/G)GAAGA reference, missense, synonymous-codon
rs9661258 -- 151,769,324(+) tgacc(A/C/G)ggcgg intron-variant

Relevant External Links for OAZ3 Gene

HapMap Linkage Disequilibrium report
OAZ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OAZ3 Gene

Disorders for OAZ3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for OAZ3 Gene in MalaCards »

(2) Diseases for OAZ3 Gene including...

Relevant External Links for OAZ3

Genetic Association Database (GAD)
OAZ3
Human Genome Epidemiology (HuGE) Navigator
OAZ3
genes like me logo Genes that share disorders with OAZ3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OAZ3 Gene

Publications for OAZ3 Gene

  1. Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3. (PMID: 16542438) Christensen G.L. … Carrell D.T. (BMC Med. Genet. 2006) 3 23 48
  2. Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3. (PMID: 10781085) Ivanov I.P. … Atkins J.F. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4
  3. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. (PMID: 17900240) Kanerva K. … Andersson L.C. (Biochem. J. 2008) 3 4
  4. ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1. (PMID: 18062773) Snapir Z. … Kahana C. (Biochem. J. 2008) 3 23
  5. Antizyme 3 inhibits polyamine uptake and ornithine decarboxylase (ODC) activity, but does not stimulate ODC degradation. (PMID: 19076071) Snapir Z. … Kahana C. (Biochem. J. 2009) 23

Products for OAZ3 Gene

Sources for OAZ3 Gene

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