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OAZ3 Gene

protein-coding   GIFtS: 51

GC01P150002
ornithine decarboxylase antizyme 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for OAZ3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
AZ3 2, 3
OAZ-t 2
TISP15 2
Descriptions
ODC-Az 3 3
antizyme 3 2
ornithine decarboxylase antizyme 3 2
External Ids
HGNC: 80971
Entrez Gene: 516862
UniProtKB: Q9UMX23
Ensembl: ENSG000001434507
Search outside databases for aliases for OAZ3 gene

Previous GC identifers: GC01P149579 GC01P147521 GC01P148514 GC01P148955 GC01P148552

Summaries
for OAZ3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for OAZ3:
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and
apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes
play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine
decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational
frameshifting. In contrast to antizymes 1 and 2, which are widely expressed throughout the body,
the expression of this gene product (antizyme 3) is restricted to testis germ cells, and thus it
is a possible candidate for heritable forms of human male infertility. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. [provided by
RefSeq]

UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2
Function: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine
decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the
intracellular concentration of polyamines in haploid germ cells

Genomic Location
for OAZ3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OAZ3 gene  

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

OAZ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P150002:     (about GC identifiers)

Start:
 150,002,236 bp from pter
End:
 150,010,429 bp from pter
Size:
 8,194 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  

Proteins
for OAZ3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2 (See protein sequence)
Recommended Name: Ornithine decarboxylase antizyme 3  
Size: 187 amino acids; 21375 Da
Subunit: Interacts with GGN (By similarity)
Subcellular location: Nucleus. Cytoplasm (By similarity)
Developmental stage: Expression starts early in spermiogenesis and finishes in the late spermatid
phase
Miscellaneous: A ribosomal frameshift occurs between the codons for Ser-28 and Glu-29. An
autoregulatory mechanism enables modulation of frameshifting according to the cellular
concentration of polyamines
Ribosomal frameshifting: 1 isoform:  Q9UMX2-1   (A ribosomal frameshift occurs between the codons for Ser-28 and Glu-29. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines)

REFSEQ proteins (2 alternative transcripts): 
NP_001128411.1  NP_057262.2  


ENSEMBL proteins: 
ENSP00000357820 ENSP00000313922 ENSP00000383784 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (OAZ3)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
GO:0005737 cytoplasm IEA--
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Antibodies for OAZ3: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Monoclonal and Polyclonal Antibodies from Abnova (OAZ3)
Novus Biologicals Antibody for OAZ3

Assays for OAZ3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for OAZ3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR002993 ODC_AZ


   GeneDecks  OAZ3 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9UMX2

ProtoNet protein and cluster: Q9UMX2

1 Blocks protein family: IPB002993 Ornithine decarboxylase antizyme

UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2
Similarity: Belongs to the ODC antizyme family

Gene Function
for OAZ3

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (OAZ3)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001134939

              Applied Biosystems Silencer® siRNAs for OAZ3

              Sigma-Aldrich siRNA for OAZ3  
                     Sigma-Aldrich shRNA for OAZ3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for OAZ3
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001134939
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001134939
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001134939 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_016178

UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2
Function: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine
decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the
intracellular concentration of polyamines in haploid germ cells

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008073 ornithine decarboxylase inhibitor activity TAS10781085
About this table

Pathways & Interactions
for OAZ3

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Sigma-Aldrich "Your Favorite Gene" Pathway for  OAZ3  (Your Favorite Gene powered by Ingenuity) 
 Polyamine Regulation in Colon Cancer

   GeneDecks  OAZ3 for the pathways selected above  
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5/49 Interacting proteins for OAZ3 (ENSP000003578203) via UniProtKB, MINT, and/or STRING (see all 49 )
InteractantInteraction Details
GeneCardExternal ID(s)
ODC1ENSP000002341113STRING (score=.986)
OAZ1ENSP000003148133STRING (score=.966)
AZIN1ENSP000003371803STRING (score=.962)
OAZ2ENSP000003162643STRING (score=.913)
ENSG00000206298ENSP000003727233STRING (score=.899)
About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007283 spermatogenesis TAS10781085
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Drugs & Compounds
for OAZ3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OAZ3

Transcripts
for OAZ3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (OAZ3)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001134939

              Sigma-Aldrich siRNA for OAZ3  
                     Sigma-Aldrich shRNA for OAZ3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001134939  NM_016178  

REFSEQ mRNAs for OAZ3 gene (2 alternative transcripts): 

NM_001134939.1   NM_016178.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001134939  NM_016178  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001134939
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001134939
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001134939 

Additional cDNA sequence: 

AF175296.1 AK125876.1 AY713300.1 BC073949.1 BC128558.1 BC128559.1 

7 DOTS entries:

DT.95267421  DT.452303  DT.100749475  DT.121399295  DT.92440318  DT.100660555  DT.95237379 

24/66 AceView cDNA sequences (see all 66 ):

H85177 AA459490 AA838072 CB852451 AA258740 BF509459 BE219238 BE042957 
BX338845 BM014759 W19299 BP369161 BI830988 AI082170 AA724464 BP371024 
NM_016178 AF175296 AA682769 AA405412 AW592562 CB306718 AA689220 AA976042 

highest scoring ESTs for OAZ3:

AI217761 AW958795 BC073949 BF509459 BI754531 BI830988 BM014759 BX330531 BX338845 CB852451 

Unigene Cluster for OAZ3:

Ornithine decarboxylase antizyme 3
Hs.713789  [show with all ESTs]
Unigene Representative Sequence: AK125876


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for OAZ3

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
SP1:                    -     -                           
SP2:                    -                                 
SP3:                                                      

About this scheme

ECgene alternative splicing isoforms for OAZ3

3 Ensembl transcripts including schematic representations:
ENST00000315067  ENST00000321531  ENST00000400999  

Expression
for OAZ3

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OAZ3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OAZ3

1 / 2 / 3

5 probe-sets matching OAZ3 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
56069_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI243814 0.80 0.80 0.80 1

222075_s_at2, 3 U133-A 1 1.00 1.00 -- -- BE792072 0.60 0.75 0.68 1

213863_s_at2 U133-A 1 0.27 1.00 -- -- -- -- -- -- --

222075_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

213863_s_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
GeneDecks  OAZ3 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GAATCAGGGG

SOURCE GeneReport for Unigene cluster: Hs.713789

UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2
Tissue specificity: Testis specific

Orthologs
for OAZ3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for OAZ3 gene from 2 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 OAZ31   -- ornithine decarboxylase antizyme 3 82.16(n)
80(a)		 475850  XM_533059.2  XP_533059.1 
mouse
(Mus musculus)		 Oaz31, 5 35
 ornithine decarboxylase antizyme 31, 5 88.21(n)1
88.95(a)1		 538141  NM_016901.11  NP_058597.11 
 AB0162755  AB0458355  (see all 13)
About this table        Species with no ortholog for OAZ3

ENSEMBL Gene Tree for OAZ3

Paralogs
for OAZ3

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for OAZ3 gene
OAZ22  OAZ12  

SNPs/Variants
for OAZ3

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


4 NCBI SNPs in OAZ3 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs24953971,2
C,H150007290(-) ATCCAG/AGAAGA 2 L/P syn14Minor allele frequency- A:0.00EU EA WA 414
--
rs57777841,2
--150007258(+) CCATT-/GGCACG 2 L/ fra10--------
--
rs358423671,2
--150009288(+) CCTGG-/GAGTAC 2 G/G fra10--------
--
rs351159421,2
--150007259(+) CATTG-/GCACGG 2 A/ fra10--------
About this table
The following additional 48 SNP(s) have been found in Applied Biosystems data source:
(Click for Applied Biosystems TaqMan ® Genotyping Assay)


 rs4845542 rs2495396 rs11204885 rs1781423 rs6673002 rs6677429 rs3923394
 rs1996731 rs1196455 rs10888433 rs3811413 rs17568246 rs1781422 rs11204883
 rs1568485 rs11204886 rs1123855 rs1781419 rs6684101 rs6683364 rs10888432
 rs10218531 rs1781424 rs1781421 rs12066445 rs1781420 rs1054477 rs4634911
 rs1623480 rs12754510 rs1054479 rs1996732 rs3790513 rs1996729 rs1196457
 rs4484926 rs1054481 rs17853082 rs16833538 rs6587618 rs1054475 rs6672920
 rs3790514 rs6692364 rs8480 rs7007 rs3748612 rs12028076

HapMap Linkage Disequilibrium images for OAZ3 (up to first 250kb)

Disorders & Mutations
for OAZ3

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 605138

1 PharmGKB disease relationship for OAZ3 gene
Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1FA  GN  12730115
About this table

Human Genome Epidemiology Navigator: OAZ3 (1 document)

Medical News
for OAZ3

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for OAZ3

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/13 PubMed articles for OAZ3 gene (see all 13 ):

Search for OAZ3

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing OAZ3

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 51686 HGNC: 8097 AceView: OAZ3 Ensembl:ENSG00000143450 euGenes: HUgn51686
ECgene: OAZ3 H-InvDB: OAZ3

Other Databases showing OAZ3

(According to HUGE)
About This Section

   --

Specialized Databases showing OAZ3

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for OAZ3

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for OAZ3

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OAZ3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for OAZ3-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for OAZ3 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OAZ3 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Antibodies for OAZ3

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