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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OAZ3 Gene

protein-coding   GIFtS: 52
GCID: GC01P151735

Ornithine Decarboxylase Antizyme 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ornithine Decarboxylase Antizyme 31 2
AZ32 3
ODC-Az 32 3
OAZ-t2
TISP152
Antizyme 32

External Ids:    HGNC: 80971   Entrez Gene: 516862   Ensembl: ENSG000001434507   OMIM: 6051385   UniProtKB: Q9UMX23   

Export aliases for OAZ3 gene to outside databases

Previous GC identifers: GC01P149579 GC01P147521 GC01P148514 GC01P148955 GC01P148552 GC01P150002 GC01P123112


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OAZ3 Gene:
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently
rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation
of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is
auto-regulated by polyamine-enhanced translational frameshifting. In contrast to antizymes 1 and 2, which are
widely expressed throughout the body, the expression of this gene product (antizyme 3) is restricted to testis
germ cells, and thus it is a possible candidate for heritable forms of human male infertility. Alternatively
spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep
2008)

GeneCards Summary for OAZ3 Gene: 
OAZ3 (ornithine decarboxylase antizyme 3) is a protein-coding gene. Diseases associated with OAZ3 include male infertility, and infertility, and among its related super-pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Metabolic pathways. GO annotations related to this gene include ornithine decarboxylase inhibitor activity. An important paralog of this gene is OAZ2.

UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2
Function: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase
degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of
polyamines in haploid germ cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OAZ3 gene promoter:
         PPAR-gamma1   POU2F1   POU2F1a   FOXO4   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOAZ3 promoter sequence
   Search SABiosciences Chromatin IP Primers for OAZ3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OAZ3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

OAZ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OAZ3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151735:  view genomic region     (about GC identifiers)

Start:
151,735,445 bp from pter      End:
151,743,808 bp from pter
Size:
8,364 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2 (See protein sequence)
Recommended Name: Ornithine decarboxylase antizyme 3  
Size: 187 amino acids; 21375 Da
Subunit: Interacts with GGN (By similarity)
Subcellular location: Nucleus. Cytoplasm (By similarity)
Developmental stage: Expression starts early in spermiogenesis and finishes in the late spermatid phase
Miscellaneous: A ribosomal frameshift occurs between the codons for Ser-28 and Glu-29. An autoregulatory mechanism
enables modulation of frameshifting according to the cellular concentration of polyamines
Ribosomal frameshifting: 1 isoform:  Q9UMX2-1   

Explore the universe of human proteins at neXtProt for OAZ3: NX_Q9UMX2

Explore proteomics data for OAZ3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UMX2

  • OAZ3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OAZ3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001128411.1  NP_057262.2  

    ENSEMBL proteins: 
     ENSP00000313922   ENSP00000415904   ENSP00000463055   ENSP00000383784   ENSP00000463692  
     ENSP00000357820  
    Reactome Protein details: Q9UMX2
    Human Recombinant Protein Products for OAZ3: 
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    Novus Biologicals OAZ3 Protein
    Novus Biologicals OAZ3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OAZ3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    OAZ3 for ontologies           About GeneDecksing



    OAZ3 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for OAZ3 
    Cloud-Clone Corp. CLIAs for OAZ3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002993 ODC_AZ
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q9UMX2

    ProtoNet protein and cluster: Q9UMX2

    1 Blocks protein domain: IPB002993 Ornithine decarboxylase antizyme

    UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2
    Similarity: Belongs to the ODC antizyme family


    OAZ3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OAZ3_HUMAN, Q9UMX2
    Function: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase
    degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of
    polyamines in haploid germ cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ----
    GO:0005515protein binding ----
    GO:0008073ornithine decarboxylase inhibitor activity IEA--
         
    OAZ3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Oaz3):
     reproductive system 

    OAZ3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Oaz3tm1Htan for OAZ3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OAZ3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OAZ3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OAZ3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OAZ3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OAZ3
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate OAZ3:
    hsa-miR-92a hsa-miR-4325 hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b hsa-miR-384
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of OAZ3

    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OAZ3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OAZ3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of ornithine decarboxylase (ODC)0.80
    2Metabolism
    Metabolism0.40
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for OAZ3
        Regulation of ornithine decarboxylase (ODC)
    Metabolism
    Metabolism of amino acids and derivatives



    OAZ3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OAZ3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for OAZ3 (Q9UMX23 ENSP000003139224) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OAZ1P543683, ENSP000003148134I2D: score=1 STRING: ENSP00000314813
    GGNQ86UU53, ENSP000003349404I2D: score=2 STRING: ENSP00000334940
    ODC1P119263, ENSP000002341114I2D: score=1 STRING: ENSP00000234111
    SMAD1Q157973, ENSP000003057694I2D: score=1 STRING: ENSP00000305769
    AZIN1ENSP000003215074STRING: ENSP00000321507
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006521regulation of cellular amino acid metabolic process TAS--
    GO:0007283spermatogenesis TAS10781085
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    OAZ3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OAZ3

    1 HMDB Compound for OAZ3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ornithine(+)-S-Ornithine (see all 9)70-26-8--

    1 DrugBank Compound for OAZ3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Ornithine(S)-2,5-Diaminopentanoate (see all 4)70-26-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about OAZ3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OAZ3 gene (2 alternative transcripts): 
    NM_001134939.1  NM_016178.2  

    Unigene Cluster for OAZ3:

    Ornithine decarboxylase antizyme 3
    Hs.713789  [show with all ESTs]
    Unigene Representative Sequence: AK125876
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321531(uc010pdl.2) ENST00000453029 ENST00000479764 ENST00000400999(uc010pdm.2)
    ENST00000577465 ENST00000582415 ENST00000315067
    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate OAZ3:
    hsa-miR-92a hsa-miR-4325 hsa-miR-363 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-92b hsa-miR-384
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OAZ3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OAZ3
    Sirion Biotech Customized lentivirus for stable overexpression of OAZ3 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OAZ3

    Additional mRNA sequence: 

    AF175296.1 AK125876.1 AY713300.1 BC073949.1 BC128558.1 BC128559.1 

    7 DOTS entries:

    DT.95267421  DT.452303  DT.100749475  DT.121399295  DT.92440318  DT.100660555  DT.95237379 

    24/66 AceView cDNA sequences (see all 66):

    BE042957 H85177 BF509459 AA459490 AA258740 CB852451 BE219238 AA838072 
    BI754531 BP371199 AA724464 AI352475 BP369217 AA074477 BE792072 BX338845 
    AA682769 AA629302 AA976042 W07747 BP371024 BM014759 AA459486 BP369551 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for OAZ3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
    SP1:                    -     -                           
    SP2:                    -                                 
    SP3:                                                      


    ECgene alternative splicing isoforms for OAZ3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OAZ3 expression in normal human tissues (normalized intensities)      OAZ3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATCAGGGG
    OAZ3 Expression
    About this image


    OAZ3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
             sperm   
     
     Skeletal Muscle (Muscoskeletal System)
             gastrocnemius muscle   
     
     Prostate (Endocrine System)
             prostate gland   

    See OAZ3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OAZ3

    SOURCE GeneReport for Unigene cluster: Hs.713789

    UniProtKB/Swiss-Prot: OAZ3_HUMAN, Q9UMX2
    Tissue specificity: Testis specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OAZ3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OAZ3 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oaz31 , 5 ornithine decarboxylase antizyme 31, 5 88.79(n)1
    89.08(a)1
      3 (40.66 cM)5
    538141  NM_016901.21  NP_058597.21 
     944333905 
    lizard
    (Anolis carolinensis)
    Reptilia OAZ36
    ornithine decarboxylase antizyme 3
    46(a)
    1 ↔ 1
    GL344382.1(15885-21562)
    fruit fly
    (Drosophila melanogaster)
    Insecta Oda6
    Ornithine decarboxylase antizyme
    15(a)
    1 → many
    2R(8054077-8061767)


    ENSEMBL Gene Tree for OAZ3 (if available)
    TreeFam Gene Tree for OAZ3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OAZ3 gene
    OAZ22  OAZ12  
    2 SIMAP similar genes for OAZ3 using alignment to 6 protein entries:     OAZ3_HUMAN (see all proteins):
    OAZ2    OAZ1

    OAZ3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/257 SNPs in OAZ3 are shown (see all 257)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456362151,2
    C--123110407(+) GTAGAC/TTCACA 1 -- us2k10--------
    rs1488943471,2
    --123110507(+) AGACAA/GGAAAT 1 -- us2k10--------
    rs1868440481,2
    --123110602(+) TGCAAA/TCTAAC 1 -- us2k10--------
    rs1916893881,2
    --123110632(+) TACAAA/CTGGAT 1 -- us2k10--------
    rs1830868001,2
    --123110638(+) TGGATA/GATCAC 1 -- us2k10--------
    rs750614661,2
    C,F--123110684(+) CTTTCC/GAGAGG 1 -- us2k12Minor allele frequency- G:0.14WA NA 238
    rs1880194741,2
    C--123110833(+) AATTTA/C/TACTGT 1 -- us2k10--------
    rs1427339501,2
    C--123110852(+) ATTAT-/GGAGTT 1 -- us2k10--------
    rs11964541,2
    C,A--123110946(+) GGGAGG/ACCAAG 1 -- us2k15Minor allele frequency- A:0.21NA WA EA 244
    rs1904084381,2
    --123111014(+) ATGGCA/GAAACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OAZ3 (151735445 - 151743808 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OAZ3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OAZ3
    DNA2.0 Custom Variant and Variant Library Synthesis for OAZ3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605138    OMIM disorders: --

    2 diseases for OAZ3:    About MalaCards
    male infertility    infertility


    OAZ3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OAZ3
    Human Genome Epidemiology (HuGE) Navigator: OAZ3 (1 document)

    Export disorders for OAZ3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OAZ3 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with OAZ3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3. (PubMed id 10781085)1, 2, 3 Ivanov I.P....Atkins J.F. (2000)
    2. Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3. (PubMed id 16542438)1, 4, 9 Christensen G.L....Carrell D.T. (2006)
    3. ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1. (PubMed id 18062773)1, 9 Snapir Z....Kahana C. (2008)
    4. Ornithine decarboxylase antizyme Oaz3 modulates prote in phosphatase activity. (PubMed id 21712390)1 Ruan Y....van der Hoorn F.A. (2011)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    7. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    8. Regulation of all members of the antizyme family by antizyme inhibitor. (PubMed id 15355308)1 Mangold U. and Leberer E. (2005)
    9. Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. (PubMed id 15642376)1 Zhang J....Lu B. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51686 HGNC: 8097 AceView: OAZ3 Ensembl:ENSG00000143450 euGenes: HUgn51686
    ECgene: OAZ3 H-InvDB: OAZ3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OAZ3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OAZ3 gene:
    Search GeneIP for patents involving OAZ3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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