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OAZ2 Gene

protein-coding   GIFtS: 53
GCID: GC15M064979

Ornithine Decarboxylase Antizyme 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ornithine Decarboxylase Antizyme 21 2
AZ22 3
ODC-Az 22 3

External Ids:    HGNC: 80961   Entrez Gene: 49472   Ensembl: ENSG000001803047   OMIM: 6041525   UniProtKB: O951903   

Export aliases for OAZ2 gene to outside databases

Previous GC identifers: GC15P060699 GC15M9D0083 GC15M062558 GC15M062766 GC15M041805


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OAZ2 Gene:
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently
rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation
of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is
auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits
ornithine decarboxylase but does not accelerate its degradation. (provided by RefSeq, Jul 2008)

GeneCards Summary for OAZ2 Gene:
OAZ2 (ornithine decarboxylase antizyme 2) is a protein-coding gene. GO annotations related to this gene include ornithine decarboxylase inhibitor activity. An important paralog of this gene is OAZ3.

UniProtKB/Swiss-Prot: OAZ2_HUMAN, O95190
Function: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase
degeneration (By similarity)

Gene Wiki entry for OAZ2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the OAZ2 gene promoter:
         STAT1   STAT4   SREBP-1c   STAT1beta   STAT1alpha   SREBP-1b   SREBP-1a   STAT2   STAT3   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOAZ2 promoter sequence
   Search Chromatin IP Primers for OAZ2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OAZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

OAZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OAZ2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M064979:  view genomic region     (about GC identifiers)

Start:
64,979,772 bp from pter      End:
64,995,480 bp from pter
Size:
15,709 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OAZ2_HUMAN, O95190 (See protein sequence)
Recommended Name: Ornithine decarboxylase antizyme 2  
Size: 189 amino acids; 21011 Da
Ribosomal frameshifting: 1 isoform:  O95190-1   

Explore the universe of human proteins at neXtProt for OAZ2: NX_O95190

Explore proteomics data for OAZ2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OAZ2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002528.1  
    ENSEMBL proteins: 
     ENSP00000463013   ENSP00000462354   ENSP00000463729   ENSP00000462192  
    Reactome Protein details: O95190

    OAZ2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002993 ODC_AZ
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry O95190

    ProtoNet protein and cluster: O95190

    1 Blocks protein domain: IPB002993 Ornithine decarboxylase antizyme

    UniProtKB/Swiss-Prot: OAZ2_HUMAN, O95190
    Similarity: Belongs to the ODC antizyme family


    Find genes that share domains with OAZ2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OAZ2_HUMAN, O95190
    Function: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase
    degeneration (By similarity)

         Genatlas biochemistry entry for OAZ2:
    ornithine decarboxylase antizyme 2,negative regulator of polyamine level

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ----
    GO:0005515protein binding ----
    GO:0008073ornithine decarboxylase inhibitor activity IEA--
         
    Find genes that share ontologies with OAZ2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OAZ2:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OAZ2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OAZ2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OAZ2

    miRNA
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    miRTarBase miRNAs that target OAZ2:
    hsa-mir-222-3p (MIRT046724), hsa-mir-26b-5p (MIRT029932)

    Block miRNA regulation of human, mouse, rat OAZ2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OAZ2 (see all 23):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-3607-5p hsa-miR-4307 hsa-miR-1257 hsa-miR-570 hsa-miR-3143 hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidOAZ2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OAZ2
    Predesigned siRNA for gene silencing in human, mouse, rat OAZ2

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    GenScript: all cDNA clones in your preferred vector: OAZ2 (NM_002537)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OAZ2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OAZ2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for OAZ2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OAZ2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OAZ2_HUMAN, O95190: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with OAZ2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OAZ2 About    
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of ornithine decarboxylase (ODC)0.80
    2Metabolism
    Metabolism0.38
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives


    Find genes that share SuperPaths with OAZ2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OAZ2
        Regulation of ornithine decarboxylase (ODC)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OAZ2
    Interactions:

        GeneGlobe Interaction Network for OAZ2

    3 Interacting proteins for OAZ2 (O951903) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AZIN1O149773I2D: score=2 
    ODC1P119263I2D: score=2 
    OAZ1P543683I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006521regulation of cellular amino acid metabolic process TAS--
    GO:0006595polyamine metabolic process TAS9428668
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0043086negative regulation of catalytic activity TAS9428668
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with OAZ2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OAZ2

    1 HMDB Compound for OAZ2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ornithine(+)-S-Ornithine (see all 9)70-26-8--

    1 DrugBank Compound for OAZ2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Ornithine(S)-2,5-Diaminopentanoate (see all 4)70-26-8target--17139284 17016423

    1 Novoseek inferred chemical compound relationship for OAZ2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ornithine 56.2 1 19960435 (1), 10352227 (1)



    Find genes that share compounds with OAZ2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OAZ2 gene: 
    NM_002537.2  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326005(uc002ano.2) ENST00000558194 ENST00000560258 ENST00000559753
    ENST00000560837 ENST00000559912 ENST00000560781 ENST00000559665 ENST00000559555

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OAZ2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OAZ2 (see all 23):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-3607-5p hsa-miR-4307 hsa-miR-1257 hsa-miR-570 hsa-miR-3143 hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidOAZ2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OAZ2
    Predesigned siRNA for gene silencing in human, mouse, rat OAZ2
    Clone
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    OriGene ORF clones in mouse, rat for OAZ2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OAZ2 (NM_002537)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OAZ2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OAZ2
    Primer
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    OriGene qPCR primer pairs and template standards for OAZ2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OAZ2
      QuantiTect SYBR Green Assays in human, mouse, rat OAZ2
      QuantiFast Probe-based Assays in human, mouse, rat OAZ2

    Selected AceView cDNA sequences (see all 633):

    BM712136 CA309094 BP374955 AI871040 BM991000 BQ181570 BQ882711 BM987708 
    AI368528 BI761868 N95460 BM693086 CR603676 CD674691 BI438989 BP374767 
    CR626244 BM846272 BU194324 CR606371 BP374664 AA603032 AL561239 AL710926 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OAZ2 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^ 11
    SP1:                    -     -     -     -                 -                             -                                             
    SP2:                    -     -     -     -                 -           -     -     -     -                                             
    SP3:                    -     -     -     -                 -                             -                                             
    SP4:                          -     -     -                 -                             -                                             
    SP5:                                                        -                             -                                             


    ECgene alternative splicing isoforms for OAZ2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OAZ2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGGAGGG
    OAZ2 Expression
    About this image


    OAZ2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Lung (Respiratory System)
    OAZ2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OAZ2 Protein Expression
        Custom PCR Arrays for OAZ2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OAZ2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for OAZ2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oaz21 , 5 ornithine decarboxylase antizyme 21, 5 97.35(n)1
    99.47(a)1
      9 (35.45 cM)5
    182471  NM_010952.31  NP_035082.11 
     656680015 
    chicken
    (Gallus gallus)
    Aves OAZ21 ornithine decarboxylase antizyme 2 86.24(n)
    91.01(a)
      427481  NM_001142862.1  NP_001136334.1 
    lizard
    (Anolis carolinensis)
    Reptilia OAZ26
    ornithine decarboxylase antizyme 2
    92(a)
    1 ↔ 1
    GL343490.1(570376-581678)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686102 hypothetical protein MGC68610 80.19(n)    BC059788.1 
    zebrafish
    (Danio rerio)
    Actinopterygii oaz12 ornithine decarboxylase antizyme 1 78.16(n)   259192  AB017117.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Oda6
    Ornithine decarboxylase antizyme
    18(a)
    1 → many
    2R(8054077-8061767)


    ENSEMBL Gene Tree for OAZ2 (if available)
    TreeFam Gene Tree for OAZ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OAZ2 gene
    OAZ32  OAZ12  
    2 SIMAP similar genes for OAZ2 using alignment to 4 protein entries:     OAZ2_HUMAN (see all proteins):
    OAZ1    OAZ3

    Find genes that share paralogs with OAZ2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OAZ2 (see all 329)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs74037511,2
    C,F,A,H--64979291(+) ACTGAC/GAGCTT 1 -- ds500117Minor allele frequency- G:0.29NS EA NA WA CSA 795
    rs1906958711,2
    --64979300(+) TTATTC/TATCAG 1 -- ds50010--------
    rs1408245381,2
    --64979340(+) CTTAGA/GACACT 1 -- ds50010--------
    rs169481821,2
    C,F,H--64979382(+) AGGTGT/GGTGCT 1 -- ds500119Minor allele frequency- G:0.12NA NS WA CSA 1858
    rs1815650351,2
    --64979462(+) ACCCAA/GCCTCC 1 -- ds50010--------
    rs1446204931,2
    --64979518(+) GGGTAC/TAGCCT 1 -- ds50010--------
    rs1125507211,2
    C--64979537(+) GAAGCTGAT/-  
            
    TGATA
    1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs569954571,2
    C--64979549(+) CACAT-/ATCTCTC 1 -- ds50010--------
    rs719317421,2
    C--64979550(+) ACACA-/ATTCTCT 1 -- ds50010--------
    rs1385786611,2
    --64979634(+) AGAGAA/CCTCAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for OAZ2 (64979772 - 64995480 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OAZ2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833038CNV Loss17160897
    esv22620CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OAZ2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604152    OMIM disorders: --


    Find genes that share disorders with OAZ2           About GenesLikeMe


    Export disorders for OAZ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OAZ2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with OAZ2)
        Utopia: connect your pdf to the dynamic
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    1. Structure of human ornithine decarboxylase antizyme 2 gene. (PubMed id 10352227)1, 2, 3, 9 Zhou J.... Gesteland R.F. (Gene 1999)
    2. A second mammalian antizyme: conservation of programmed ribosomal frameshifting. (PubMed id 9782076)1, 2, 3 Ivanov I.P.... Atkins J.F. (Genomics 1998)
    3. The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification. (PubMed id 19960435)1, 9 Geerts D....Bachmann A.S. (Int. J. Cancer 2010)
    4. Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide. (PubMed id 23260169)1 Gross J.A....Turecki G. (J Psychiatr Res 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide. (PubMed id 22008221)1 Fiori L.M....Turecki G. (Int. J. Neuropsychopharmacol. 2012)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    9. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4947 HGNC: 8096 AceView: OAZ2 Ensembl:ENSG00000180304 euGenes: HUgn4947
    ECgene: OAZ2 H-InvDB: OAZ2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OAZ2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OAZ2 gene:
    Search GeneIP for patents involving OAZ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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