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OAZ2 Gene

protein-coding   GIFtS: 49

GC15M062766
ornithine decarboxylase antizyme 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AZ2 2, 3
Descriptions
ODC-Az 2 3
ornithine decarboxylase antizyme 2 2
External Ids
HGNC: 80961
Entrez Gene: 49472
UniProtKB: O951903
Ensembl: ENSG000001803047
Search outside databases for aliases for OAZ2 gene

Previous GC identifers: GC15P060699 GC15M9D0083 GC15M062558

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for OAZ2:
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and
apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes
play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine
decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational
frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not
accelerate its degradation. [provided by RefSeq]

UniProtKB/Swiss-Prot: OAZ2_HUMAN, O95190
Function: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine
decarboxylase degeneration (By similarity)

Gene Wiki entry for OAZ2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OAZ2 gene  

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

OAZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M062766:     (about GC identifiers)

Start:
62,766,828 bp from pter
End:
62,782,507 bp from pter
Size:
15,680 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000015.8  NT_010194.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OAZ2_HUMAN, O95190 (See protein sequence)
Recommended Name: Ornithine decarboxylase antizyme 2  
Size: 189 amino acids; 21011 Da
Ribosomal frameshifting: 1 isoform:  O95190-1   (A ribosomal frameshift occurs between the codons for Ser-32 and Asp-33. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines)

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002528.1  

    ENSEMBL proteins: 
    ENSP00000385120 ENSP00000316264 


    Human Recombinant Proteins 
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                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for OAZ2: 
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    Assays for OAZ2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
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    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR002993 ODC_AZ


       GeneDecks  OAZ2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O95190

    ProtoNet protein and cluster: O95190

    1 Blocks protein family: IPB002993 Ornithine decarboxylase antizyme

    UniProtKB/Swiss-Prot: OAZ2_HUMAN, O95190
    Similarity: Belongs to the ODC antizyme family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002537

                  Applied Biosystems Silencer® siRNAs for OAZ2

                  Sigma-Aldrich siRNA for OAZ2  
                         Sigma-Aldrich shRNA for OAZ2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002537
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002537
                                     untagged cDNA clone in CMV expression vector: NM_002537 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002537

    UniProtKB/Swiss-Prot: OAZ2_HUMAN, O95190
    Function: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine
    decarboxylase degeneration (By similarity)

    Genatlas biochemistry entry for OAZ2:
    ornithine decarboxylase antizyme 2,negative regulator of polyamine level

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI17353931
    GO:0008073 ornithine decarboxylase inhibitor activity TAS9428668
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  OAZ2  (Your Favorite Gene powered by Ingenuity) 
     Polyamine Regulation in Colon Cancer

       GeneDecks  OAZ2 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  OAZ2 


    5/46 Interacting proteins for OAZ2 (O951901 ENSP000003162643) via UniProtKB, MINT, and/or STRING (see all 46 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ODC1P119261, ENSP000002341113EBI-1051861, EBI-1044287 STRING (score=.996)
    AZIN1O149771, ENSP000003371803EBI-1051861, EBI-1054824 STRING (score=.98)
    OAZ1ENSP000003148133STRING (score=.963)
    OAZ3ENSP000003578203STRING (score=.913)
    ENSG00000206298ENSP000003727233STRING (score=.899)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006595 polyamine metabolic process TAS9428668
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for OAZ2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002537

                  Sigma-Aldrich siRNA for OAZ2  
                         Sigma-Aldrich shRNA for OAZ2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002537  

    REFSEQ mRNAs for OAZ2 gene: 

    NM_002537.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002537  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002537
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002537
                                     untagged cDNA clone in CMV expression vector: NM_002537 

    Additional cDNA sequence: 

    AF057297.1 AF242521.1 BC035493.2 BC047755.1 BC063577.1 BC073877.1 BC092483.1 BC119629.1 
    BC119630.1 BC127630.1 BC127631.1 BC148316.2 CR590699.1 CR590996.1 CR593659.1 CR594645.1 
    CR596383.1 CR601685.1 CR603676.1 CR604161.1 CR606371.1 CR611250.1 CR612625.1 CR616925.1 
    CR624771.1 CR626244.1 

    23 DOTS entries:

    DT.100835110  DT.448384  DT.95172493  DT.100835867  DT.100835863  DT.97762211  DT.99980709  DT.121043899 
    DT.92447935  DT.308927  DT.100835859  DT.121043905  DT.92447930  DT.121043901  DT.91920298  DT.95172487 
    DT.100038038  DT.100801156  DT.100835870  DT.121043848  DT.121043900  DT.95206472  DT.100695819 

    24/633 AceView cDNA sequences (see all 633 ):

    AL561239 AI401756 AL582164 BP374767 BM839424 BX423502 BM847389 BQ186450 
    AI889062 CD171729 BQ718478 AI492608 BM670194 BQ083168 CR594645 BM810577 
    BM991000 N95460 CA309094 AI871315 CR593659 BI438989 BG674335 AL553444 

    highest scoring ESTs for OAZ2:

    AA017638 AA019685 AA213536 AA463787 AF057297 AF242521 AI205311 AL601163 AL694886 AL710136 

    Unigene Cluster for OAZ2:

    Ornithine decarboxylase antizyme 2
    Hs.74563  [show with all ESTs]
    Unigene Representative Sequence: NM_002537


    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for OAZ2 (see all 12 )

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^ 11
    SP1:                    -     -     -     -                 -                             -                                             
    SP2:                    -     -     -     -                 -           -     -     -     -                                             
    SP3:                    -     -     -     -                 -                             -                                             
    SP4:                          -     -     -                 -                             -                                             
    SP5:                                                        -                             -                                             

    About this scheme

    ECgene alternative splicing isoforms for OAZ2

    2 Ensembl transcripts including schematic representations:
    ENST00000403937  ENST00000326005  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    OAZ2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for OAZ2

    1 / 2 / 3

    7 probe-sets matching OAZ2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    36146_at2, 3 U95-A 1 1.00 1.00 0.79 0.94 AF057297 0.80 1.00 0.91 1

    74876_r_at2, 3 U95-D 1 0.94 1.00 0.82 1.01 AI954757 0.60 1.00 0.82 1
    74874_i_at2, 3 U95-D 1 0.77 1.00 0.94 1.05 AI954757 0.60 1.00 0.82 1

    201364_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF242521 0.80 1.00 0.91 1

    201365_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002537 0.60 1.00 0.82 1

    201364_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    201365_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  OAZ2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.74563

    Expression variation in blood from EXPOLDB for OAZ2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for OAZ2 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    OAZ21   -- ornithine decarboxylase antizyme 2 98.51(n)
    100(a)
    478343  XM_848284.1  XP_853377.1 
    chimpanzee
    (Pan troglodytes)
    OAZ21   -- ornithine decarboxylase antizyme 2 99.58(n)
    100(a)
    747719  XM_001158081.1  XP_001158081.1 
    mouse
    (Mus musculus)
    Oaz21, 5 95
    ornithine decarboxylase antizyme 21, 5 97.35(n)1
    99.47(a)1
    182471  NM_010952.21  NP_035082.11 
     AF0572985  AK1432315  (see all 27)
    zebrafish
    (Danio rerio)
    oaz12   -- ornithine decarboxylase antizyme 1 78.16(n) 259192  AB017117.1 
    African clawed frog
    (Xenopus laevis)
    MGC686102   -- hypothetical protein MGC68610 80.19(n)  BC059788.1 
    About this table        Species with no ortholog for OAZ2

    ENSEMBL Gene Tree for OAZ2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for OAZ2 gene
    OAZ32  OAZ12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    9 NCBI SNPs in OAZ2 are shown
    (Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs178012461,2
    F,H62767812(+) TCAACT/ACCGAG 1 -- ut31 ese37Minor allele frequency- A:0.02NA EU EA WA 560
    rs10493351,2
    C62766973(-) GTGTAG/AAAGTG 1 -- ut31 ese31Minor allele frequency- A:0.00MN 184
    rs37515341,2
    H62769771(-) ACCTCC/TCTGTG 1 P/L mis1 ese35Minor allele frequency- T:0.02EA EU WA 1686
    --
    rs344699491,2
    --62782500(+) CGCCG-/GCCCCGCC 1 -- ut510--------
    --
    rs362243391,2
    --62782490(+) ACCGC-/CGC   
      CGCCGC
    CGCCG
    1 -- ut510--------
    rs10493381,2
    --62766932(-) TTTTTC/TTAAGG 1 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    --
    rs129099771,2
    --62782475(+) CCCTCC/TCCGgc 1 -- ut510--------
    --
    rs351337001,2
    --62767269(+) CCCCC-/CAAAAA 1 -- ut310--------
    --
    rs718013041,2
    --62782499(+) CCGCC-/CGCGCCGC 1 -- ut510--------
    About this table
    The following additional 25 SNP(s) have been found in Applied Biosystems data source:
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)


     rs8030063 rs16948191 rs4402501 rs11071804 rs7170201 rs8034064 rs7403751
     rs11637114 rs16948187 rs3210329 rs28512173 rs8038016 rs16948174 rs8028030
     rs7165171 rs1133357 rs59303322 rs16948172 rs12437786 rs11858605 rs7165925
     rs7497863 rs7167569 rs11631564 rs34000846

    HapMap Linkage Disequilibrium images for OAZ2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 604152

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/11 PubMed articles for OAZ2 gene (see all 11 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4947 HGNC: 8096 AceView: OAZ2 Ensembl:ENSG00000180304 euGenes: HUgn4947
    ECgene: OAZ2 H-InvDB: OAZ2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for OAZ2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for OAZ2 Browse antibodies at Sigma-Aldrich
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     Lentivirus-delivered shRNAs for OAZ2 Browse small molecules at Sigma-Aldrich
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