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Aliases & Descriptions for OAZ2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Descriptions ODC-Az 2 3 ornithine decarboxylase antizyme 2 2
Search outside databases for aliases for OAZ2 genePrevious GC identifers: GC15P060699 GC15M9D0083 GC15M062558
Summaries for OAZ2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for OAZ2 : Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first andapparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymesplay a role in the regulation of polyamine synthesis by binding to and inhibiting ornithinedecarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translationalframeshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does notaccelerate its degradation. [provided by RefSeq] UniProtKB/Swiss-Prot: OAZ2_HUMAN, O95190 Function : Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithinedecarboxylase degeneration (By similarity)
Gene Wiki entry for OAZ2
Genomic Location for OAZ2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the OAZ2 gene Entrez Gene cytogenetic band: 15q22.31 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q22.31 OAZ2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M062766:
(about GC identifiers )
Start:
62,766,828 bp from pter
End:
62,782,507 bp from pter
Size:
15,680 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000015.8 NT_010194.16 Proteins for OAZ2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: OAZ2_HUMAN, O95190 (See
protein sequence )Recommended Name: Ornithine decarboxylase antizyme 2 Size : 189 amino acids; 21011 DaRibosomal frameshifting : 1 isoform : O95190-1 (A ribosomal frameshift occurs between the codons for Ser-32 and Asp-33. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines)
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_002528.1 ENSEMBL proteins: ENSP00000385120 ENSP00000316264 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for OAZ2: Assays for OAZ2:
Protein
Domains/ Families for OAZ2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O95190 ProtoNet protein and cluster: O95190
1 Blocks protein family : IPB002993 Ornithine decarboxylase antizyme UniProtKB/Swiss-Prot: OAZ2_HUMAN, O95190 Similarity : Belongs to the ODC antizyme family
Gene Function for OAZ2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002537 Applied Biosystems Silencer ® siRNAs for OAZ2 Sigma-Aldrich siRNA for OAZ2 Sigma-Aldrich shRNA for OAZ2 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002537                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002537                                  untagged cDNA clone in CMV expression vector: NM_002537  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002537 UniProtKB/Swiss-Prot: OAZ2_HUMAN, O95190 Function : Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithinedecarboxylase degeneration (By similarity)
Genatlas biochemistry entry for OAZ2 :ornithine decarboxylase antizyme 2,negative regulator of polyamine level 2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for OAZ2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for OAZ2 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for OAZ2 5/46 Interacting proteins for OAZ2 (O95190 1 ENSP00000316264 3 ) via UniProtKB, MINT, and/or STRING (see all 46
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006595 polyamine metabolic process
TAS 9428668
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Drugs & Compounds for OAZ2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for OAZ2
Transcripts for OAZ2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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shRNA from
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002537 Sigma-Aldrich siRNA for OAZ2 Sigma-Aldrich shRNA for OAZ2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_002537
REFSEQ mRNAs for OAZ2 gene: NM_002537.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002537
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002537                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002537                                  untagged cDNA clone in CMV expression vector: NM_002537  
Additional cDNA sequence: AF057297.1 AF242521.1 BC035493.2 BC047755.1 BC063577.1 BC073877.1 BC092483.1 BC119629.1 BC119630.1 BC127630.1 BC127631.1 BC148316.2 CR590699.1 CR590996.1 CR593659.1 CR594645.1 CR596383.1 CR601685.1 CR603676.1 CR604161.1 CR606371.1 CR611250.1 CR612625.1 CR616925.1 CR624771.1 CR626244.1
23 DOTS entries : DT.100835110 DT.448384 DT.95172493 DT.100835867 DT.100835863 DT.97762211 DT.99980709 DT.121043899 DT.92447935 DT.308927 DT.100835859 DT.121043905 DT.92447930 DT.121043901 DT.91920298 DT.95172487 DT.100038038 DT.100801156 DT.100835870 DT.121043848 DT.121043900 DT.95206472 DT.100695819
24/633 AceView cDNA sequences (see all 633
):AL561239 AI401756 AL582164 BP374767 BM839424 BX423502 BM847389 BQ186450 AI889062 CD171729 BQ718478 AI492608 BM670194 BQ083168 CR594645 BM810577 BM991000 N95460 CA309094 AI871315 CR593659 BI438989 BG674335 AL553444
highest scoring ESTs for OAZ2 :AA017638 AA019685 AA213536 AA463787 AF057297 AF242521 AI205311 AL601163 AL694886 AL710136
Unigene Cluster for OAZ2: Ornithine decarboxylase antizyme 2 Hs.74563 [show with all ESTs ] Unigene Representative Sequence: NM_002537 GeneLoc Exon Structure 5/12 Alternative Splicing Database (ASD) splice patterns (SP) for OAZ2 (see all 12
) ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^ 11 SP1 :       -   -   -   -       -           -                 SP2 :       -   -   -   -       -     -   -   -   -                 SP3 :       -   -   -   -       -           -                 SP4 :         -   -   -       -           -                 SP5 :                   -           -                
About this scheme ECgene alternative splicing isoforms for OAZ2 2 Ensembl transcripts including schematic representations : ENST00000403937
ENST00000326005
Expression for OAZ2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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OAZ2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for OAZ2 1 / 2 / 3
7 probe-sets matching OAZ2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.74563 Expression variation in blood from EXPOLDB for OAZ2
Orthologs for OAZ2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for OAZ2 gene from 5 species
About this table Species with no ortholog for OAZ2 ENSEMBL Gene Tree for OAZ2 Paralogs for OAZ2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for OAZ2 gene OAZ3 2 OAZ1 2
SNPs/Variants for OAZ2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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The following additional 25 SNP(s) have been
found in Applied Biosystems data source:(Click
for
Applied Biosystems TaqMan ® Genotyping Assay ) HapMap Linkage Disequilibrium images for OAZ2 (up to first 250kb)
Disorders & Mutations for OAZ2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 604152
Medical News for OAZ2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for OAZ2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/11 PubMed articles for OAZ2 gene (see all 11
):
Search for OAZ2
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing OAZ2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing OAZ2
(According to HUGE )
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--
Specialized Databases showing OAZ2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for OAZ2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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